

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 6.11206147 |
| 2 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 5.61962575 |
| 3 | protein heterotrimerization (GO:0070208) | 5.54944436 |
| 4 | collagen fibril organization (GO:0030199) | 4.72817770 |
| 5 | mucosal-associated lymphoid tissue development (GO:0048537) | 4.70173557 |
| 6 | Peyers patch development (GO:0048541) | 4.70173557 |
| 7 | chondrocyte proliferation (GO:0035988) | 4.57529125 |
| 8 | negative regulation of mRNA processing (GO:0050686) | 4.55112833 |
| 9 | bone trabecula formation (GO:0060346) | 4.43068890 |
| 10 | negative regulation of RNA splicing (GO:0033119) | 4.37112829 |
| 11 | negative regulation of erythrocyte differentiation (GO:0045647) | 4.28971967 |
| 12 | endodermal cell differentiation (GO:0035987) | 4.25255622 |
| 13 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.13907961 |
| 14 | basement membrane organization (GO:0071711) | 4.12214394 |
| 15 | UTP biosynthetic process (GO:0006228) | 4.06057565 |
| 16 | nucleobase-containing small molecule interconversion (GO:0015949) | 4.05943060 |
| 17 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 4.04922630 |
| 18 | regulation of mitochondrial translation (GO:0070129) | 4.03850413 |
| 19 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.99451452 |
| 20 | negative regulation of mRNA metabolic process (GO:1903312) | 3.97336945 |
| 21 | DNA synthesis involved in DNA repair (GO:0000731) | 3.94205659 |
| 22 | negative regulation of JAK-STAT cascade (GO:0046426) | 3.90163326 |
| 23 | GTP biosynthetic process (GO:0006183) | 3.89750884 |
| 24 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.88144797 |
| 25 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.88144227 |
| 26 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.84991672 |
| 27 | mature B cell differentiation involved in immune response (GO:0002313) | 3.83439351 |
| 28 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 3.81920603 |
| 29 | UTP metabolic process (GO:0046051) | 3.81221802 |
| 30 | DNA strand elongation (GO:0022616) | 3.77350233 |
| 31 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.67584437 |
| 32 | wound healing, spreading of epidermal cells (GO:0035313) | 3.65961787 |
| 33 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.61863720 |
| 34 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.60210151 |
| 35 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.53037063 |
| 36 | cell migration involved in heart development (GO:0060973) | 3.52039170 |
| 37 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.49061182 |
| 38 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.49024526 |
| 39 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.49024526 |
| 40 | deoxyribonucleotide catabolic process (GO:0009264) | 3.43617467 |
| 41 | translesion synthesis (GO:0019985) | 3.41467111 |
| 42 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.36045794 |
| 43 | paraxial mesoderm development (GO:0048339) | 3.36037773 |
| 44 | dermatan sulfate biosynthetic process (GO:0030208) | 3.34944181 |
| 45 | CTP metabolic process (GO:0046036) | 3.34197855 |
| 46 | CTP biosynthetic process (GO:0006241) | 3.34197855 |
| 47 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.33760956 |
| 48 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 3.31236702 |
| 49 | polarized epithelial cell differentiation (GO:0030859) | 3.30959571 |
| 50 | deoxyribose phosphate catabolic process (GO:0046386) | 3.30085191 |
| 51 | viral transcription (GO:0019083) | 3.30064517 |
| 52 | centrosome duplication (GO:0051298) | 3.26011077 |
| 53 | folic acid metabolic process (GO:0046655) | 3.25706344 |
| 54 | epithelial cell-cell adhesion (GO:0090136) | 3.25644839 |
| 55 | cell adhesion mediated by integrin (GO:0033627) | 3.23870614 |
| 56 | definitive hemopoiesis (GO:0060216) | 3.21505731 |
| 57 | UV protection (GO:0009650) | 3.20569812 |
| 58 | translational termination (GO:0006415) | 3.20247373 |
| 59 | pinocytosis (GO:0006907) | 3.19782568 |
| 60 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.18330256 |
| 61 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.17483799 |
| 62 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 3.16812822 |
| 63 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 3.14461360 |
| 64 | base-excision repair (GO:0006284) | 3.09833720 |
| 65 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 3.07216833 |
| 66 | grooming behavior (GO:0007625) | 3.07019397 |
| 67 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.06252789 |
| 68 | axon extension involved in axon guidance (GO:0048846) | 3.06252789 |
| 69 | negative regulation of B cell apoptotic process (GO:0002903) | 3.06151208 |
| 70 | dermatan sulfate metabolic process (GO:0030205) | 3.06048454 |
| 71 | regulation of SMAD protein import into nucleus (GO:0060390) | 3.05727090 |
| 72 | skin morphogenesis (GO:0043589) | 3.04027776 |
| 73 | protein maturation by protein folding (GO:0022417) | 3.02663725 |
| 74 | post-embryonic morphogenesis (GO:0009886) | 3.00255410 |
| 75 | regulation of protein heterodimerization activity (GO:0043497) | 2.99713364 |
| 76 | regulation of tight junction assembly (GO:2000810) | 2.99499754 |
| 77 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.99389126 |
| 78 | collagen metabolic process (GO:0032963) | 2.99167121 |
| 79 | base-excision repair, AP site formation (GO:0006285) | 2.98708131 |
| 80 | wound healing, spreading of cells (GO:0044319) | 2.98576910 |
| 81 | hippo signaling (GO:0035329) | 2.98491391 |
| 82 | proline biosynthetic process (GO:0006561) | 2.98106745 |
| 83 | craniofacial suture morphogenesis (GO:0097094) | 2.97023893 |
| 84 | negative regulation of fatty acid transport (GO:2000192) | 2.95078625 |
| 85 | maturation of SSU-rRNA (GO:0030490) | 2.95032505 |
| 86 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.93824205 |
| 87 | protein retention in ER lumen (GO:0006621) | 2.92475735 |
| 88 | focal adhesion assembly (GO:0048041) | 2.92281920 |
| 89 | cell-substrate adherens junction assembly (GO:0007045) | 2.92281920 |
| 90 | rRNA transcription (GO:0009303) | 2.92129081 |
| 91 | endocardial cushion development (GO:0003197) | 2.91736337 |
| 92 | outer ear morphogenesis (GO:0042473) | 2.91464480 |
| 93 | telomere maintenance via recombination (GO:0000722) | 2.89772105 |
| 94 | endothelial tube morphogenesis (GO:0061154) | 2.89682416 |
| 95 | morphogenesis of an endothelium (GO:0003159) | 2.89682416 |
| 96 | fibril organization (GO:0097435) | 2.87921224 |
| 97 | gland morphogenesis (GO:0022612) | 2.85899501 |
| 98 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.85832930 |
| 99 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.85830217 |
| 100 | collagen catabolic process (GO:0030574) | 2.85683390 |
| 101 | translational elongation (GO:0006414) | 2.85199102 |
| 102 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.83007911 |
| 103 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.82825835 |
| 104 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.82577139 |
| 105 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.81674300 |
| 106 | mitotic recombination (GO:0006312) | 2.79804643 |
| 107 | negative regulation of cell aging (GO:0090344) | 2.79771687 |
| 108 | cranial suture morphogenesis (GO:0060363) | 2.78948483 |
| 109 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.78429320 |
| 110 | DNA unwinding involved in DNA replication (GO:0006268) | 2.76366632 |
| 111 | pyrimidine nucleotide biosynthetic process (GO:0006221) | 2.73426303 |
| 112 | plasma membrane repair (GO:0001778) | 2.73149136 |
| 113 | multicellular organismal macromolecule metabolic process (GO:0044259) | 2.72205377 |
| 114 | mitotic chromosome condensation (GO:0007076) | 2.71912338 |
| 115 | ribosomal small subunit assembly (GO:0000028) | 2.71555446 |
| 116 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.70349953 |
| 117 | lymph vessel development (GO:0001945) | 2.69305372 |
| 118 | heterochromatin organization (GO:0070828) | 2.69002707 |
| 119 | ribosomal small subunit biogenesis (GO:0042274) | 2.68038265 |
| 120 | blood vessel maturation (GO:0001955) | 2.68014144 |
| 121 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.65482807 |
| 122 | deoxyribose phosphate metabolic process (GO:0019692) | 2.65325735 |
| 123 | metanephric mesenchyme development (GO:0072075) | 2.63536838 |
| 124 | establishment of apical/basal cell polarity (GO:0035089) | 2.63475753 |
| 125 | pyrimidine nucleotide metabolic process (GO:0006220) | 2.63087456 |
| 126 | mature B cell differentiation (GO:0002335) | 2.62354515 |
| 127 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.61837419 |
| 128 | regulation of heart morphogenesis (GO:2000826) | 2.61457487 |
| 129 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 2.61214582 |
| 130 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.60723736 |
| 131 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.60325604 |
| 132 | translational initiation (GO:0006413) | 2.59038193 |
| 133 | establishment of integrated proviral latency (GO:0075713) | 2.58023620 |
| 134 | pyrimidine nucleoside biosynthetic process (GO:0046134) | 2.57026347 |
| 135 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.56129551 |
| 136 | multicellular organismal catabolic process (GO:0044243) | 2.56046482 |
| 137 | peptidyl-proline hydroxylation (GO:0019511) | 2.55314366 |
| 138 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.55065422 |
| 139 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.54601272 |
| 140 | extracellular matrix disassembly (GO:0022617) | 2.53712944 |
| 141 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.52990581 |
| 142 | extracellular fibril organization (GO:0043206) | 2.52978600 |
| 143 | endothelial cell proliferation (GO:0001935) | 2.52524772 |
| 144 | multicellular organismal metabolic process (GO:0044236) | 2.51862868 |
| 145 | adherens junction assembly (GO:0034333) | 2.51799774 |
| 146 | cell proliferation involved in metanephros development (GO:0072203) | 2.51512463 |
| 147 | viral life cycle (GO:0019058) | 2.51030961 |
| 148 | kidney mesenchyme development (GO:0072074) | 2.50839596 |
| 149 | mammary gland epithelial cell differentiation (GO:0060644) | 2.50268805 |
| 150 | DNA biosynthetic process (GO:0071897) | 2.49526676 |
| 151 | anatomical structure regression (GO:0060033) | 2.48832091 |
| 152 | protein localization to cell surface (GO:0034394) | 2.48039664 |
| 153 | protein targeting to ER (GO:0045047) | 2.47500109 |
| 154 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.46650687 |
| 155 | regulation of response to osmotic stress (GO:0047484) | 2.46444944 |
| 156 | mRNA stabilization (GO:0048255) | 2.46413457 |
| 157 | RNA stabilization (GO:0043489) | 2.46413457 |
| 158 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.46065670 |
| 159 | cellular protein complex disassembly (GO:0043624) | 2.45353775 |
| 160 | apoptotic cell clearance (GO:0043277) | 2.44925578 |
| 161 | granulocyte differentiation (GO:0030851) | 2.44761300 |
| 162 | trabecula formation (GO:0060343) | 2.44586942 |
| 163 | formation of translation preinitiation complex (GO:0001731) | 2.44197095 |
| 164 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.44053643 |
| 165 | cotranslational protein targeting to membrane (GO:0006613) | 2.43183593 |
| 166 | maternal placenta development (GO:0001893) | 2.42991640 |
| 167 | histone arginine methylation (GO:0034969) | 2.42844072 |
| 168 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.42446857 |
| 169 | negative regulation of cartilage development (GO:0061037) | 2.42369480 |
| 170 | apoptotic process involved in morphogenesis (GO:0060561) | 2.41689731 |
| 171 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 2.41160139 |
| 172 | negative regulation of DNA repair (GO:0045738) | 2.41107925 |
| 173 | negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) | 2.40191456 |
| 174 | protein hydroxylation (GO:0018126) | 2.39102449 |
| 175 | cell migration involved in sprouting angiogenesis (GO:0002042) | 2.37369560 |
| 176 | negative regulation of embryonic development (GO:0045992) | 2.33678827 |
| 177 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.33283719 |
| 178 | negative regulation of catenin import into nucleus (GO:0035414) | 2.32175328 |
| 179 | regulation of mitotic spindle organization (GO:0060236) | 2.30963433 |
| 180 | regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121 | 2.29054457 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.01320197 |
| 2 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.53987286 |
| 3 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.53330032 |
| 4 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.51966762 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.15494679 |
| 6 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.06370594 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.94948647 |
| 8 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.84942793 |
| 9 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.75960419 |
| 10 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.37236230 |
| 11 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.34544956 |
| 12 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.27504427 |
| 13 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.20477116 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.15083319 |
| 15 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.13392407 |
| 16 | MYC_22102868_ChIP-Seq_BL_Human | 1.95666686 |
| 17 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.94587428 |
| 18 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.93526066 |
| 19 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.92608509 |
| 20 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.86507299 |
| 21 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.76449294 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.75870128 |
| 23 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.74635503 |
| 24 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.73695199 |
| 25 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.72035189 |
| 26 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.71422283 |
| 27 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.71215633 |
| 28 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.71215236 |
| 29 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.70163623 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.68882341 |
| 31 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.67848831 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.65174778 |
| 33 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.63148363 |
| 34 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.61806854 |
| 35 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.60040102 |
| 36 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.58391693 |
| 37 | P68_20966046_ChIP-Seq_HELA_Human | 1.55674464 |
| 38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53426763 |
| 39 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.51230607 |
| 40 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.50587171 |
| 41 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.50369308 |
| 42 | ATF3_27146783_Chip-Seq_COLON_Human | 1.48154721 |
| 43 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.48123429 |
| 44 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.46414612 |
| 45 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.45355976 |
| 46 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.43241698 |
| 47 | MAF_26560356_Chip-Seq_TH2_Human | 1.42410704 |
| 48 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.42167850 |
| 49 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.42119344 |
| 50 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.42039396 |
| 51 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.40008337 |
| 52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.38934082 |
| 53 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.38739555 |
| 54 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.38040062 |
| 55 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.37417898 |
| 56 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.37092712 |
| 57 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.36221704 |
| 58 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.35180353 |
| 59 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.34809732 |
| 60 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.34809732 |
| 61 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.34809732 |
| 62 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.34749581 |
| 63 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.33456828 |
| 64 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.32359768 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.32151931 |
| 66 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.31796675 |
| 67 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.29400058 |
| 68 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.29193308 |
| 69 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.28943621 |
| 70 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.28236721 |
| 71 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.28180253 |
| 72 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.28068232 |
| 73 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.27504480 |
| 74 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.26062829 |
| 75 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.25409995 |
| 76 | * SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.24306331 |
| 77 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.24108651 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.21626870 |
| 79 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.21606160 |
| 80 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.21098186 |
| 81 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.20620857 |
| 82 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.20286857 |
| 83 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.18905543 |
| 84 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.18843751 |
| 85 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.18842394 |
| 86 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.18645770 |
| 87 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.18080496 |
| 88 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.18071792 |
| 89 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.17916950 |
| 90 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.17794579 |
| 91 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.17595447 |
| 92 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.17257318 |
| 93 | * MAF_26560356_Chip-Seq_TH1_Human | 1.17150053 |
| 94 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.16561072 |
| 95 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.16457307 |
| 96 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16047304 |
| 97 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.15888727 |
| 98 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.15679445 |
| 99 | UTX_26944678_Chip-Seq_JUKART_Human | 1.15636547 |
| 100 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.15585217 |
| 101 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.15463848 |
| 102 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.14879232 |
| 103 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.14261228 |
| 104 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.14107062 |
| 105 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.13771295 |
| 106 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.13771295 |
| 107 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.12894454 |
| 108 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.12729933 |
| 109 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.12693132 |
| 110 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12375393 |
| 111 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.12081834 |
| 112 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.11447902 |
| 113 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11375282 |
| 114 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.11303614 |
| 115 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.11069011 |
| 116 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.10888060 |
| 117 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.10155029 |
| 118 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10127174 |
| 119 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.09869799 |
| 120 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.09758439 |
| 121 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.09682437 |
| 122 | KDM2B_26808549_Chip-Seq_K562_Human | 1.09539320 |
| 123 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.09515901 |
| 124 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.09426712 |
| 125 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.09398771 |
| 126 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.09397560 |
| 127 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.09362674 |
| 128 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.08960418 |
| 129 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.08484353 |
| 130 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.07957616 |
| 131 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.07130367 |
| 132 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.06750058 |
| 133 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.06661185 |
| 134 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.06293120 |
| 135 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.05498025 |
| 136 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.04539642 |
| 137 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.04365782 |
| 138 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.04269680 |
| 139 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.03807286 |
| 140 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.03558807 |
| 141 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.03357856 |
| 142 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.03337264 |
| 143 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.03311527 |
| 144 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.03069447 |
| 145 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.02977760 |
| 146 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.02805724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 6.62589125 |
| 2 | MP0005503_abnormal_tendon_morphology | 4.09966482 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 4.00052774 |
| 4 | MP0005275_abnormal_skin_tensile | 3.84420486 |
| 5 | MP0003279_aneurysm | 3.54348298 |
| 6 | MP0005623_abnormal_meninges_morphology | 2.88950556 |
| 7 | MP0004272_abnormal_basement_membrane | 2.73443905 |
| 8 | MP0001958_emphysema | 2.65485673 |
| 9 | MP0004510_myositis | 2.50781239 |
| 10 | MP0010030_abnormal_orbit_morphology | 2.41327828 |
| 11 | MP0010352_gastrointestinal_tract_polyps | 2.35629779 |
| 12 | MP0005397_hematopoietic_system_phenotyp | 2.35524428 |
| 13 | MP0001545_abnormal_hematopoietic_system | 2.35524428 |
| 14 | MP0006054_spinal_hemorrhage | 2.31748664 |
| 15 | MP0003111_abnormal_nucleus_morphology | 2.18444273 |
| 16 | MP0002234_abnormal_pharynx_morphology | 2.18274438 |
| 17 | MP0005023_abnormal_wound_healing | 2.00110684 |
| 18 | MP0003566_abnormal_cell_adhesion | 1.99706259 |
| 19 | MP0009384_cardiac_valve_regurgitation | 1.97391658 |
| 20 | MP0010368_abnormal_lymphatic_system | 1.83404898 |
| 21 | MP0000490_abnormal_crypts_of | 1.82143177 |
| 22 | MP0004858_abnormal_nervous_system | 1.81122185 |
| 23 | MP0000733_abnormal_muscle_development | 1.79145941 |
| 24 | MP0005508_abnormal_skeleton_morphology | 1.76341749 |
| 25 | MP0003763_abnormal_thymus_physiology | 1.72864858 |
| 26 | MP0003385_abnormal_body_wall | 1.70638542 |
| 27 | MP0000678_abnormal_parathyroid_gland | 1.68089750 |
| 28 | MP0004185_abnormal_adipocyte_glucose | 1.67487695 |
| 29 | MP0001849_ear_inflammation | 1.66128740 |
| 30 | MP0005257_abnormal_intraocular_pressure | 1.59638311 |
| 31 | MP0005330_cardiomyopathy | 1.57564346 |
| 32 | MP0009379_abnormal_foot_pigmentation | 1.51456180 |
| 33 | MP0002060_abnormal_skin_morphology | 1.50996080 |
| 34 | MP0003693_abnormal_embryo_hatching | 1.50664028 |
| 35 | MP0001243_abnormal_dermal_layer | 1.49449966 |
| 36 | MP0000767_abnormal_smooth_muscle | 1.49289335 |
| 37 | MP0003091_abnormal_cell_migration | 1.49184779 |
| 38 | MP0009333_abnormal_splenocyte_physiolog | 1.46715185 |
| 39 | MP0008057_abnormal_DNA_replication | 1.45988521 |
| 40 | MP0010094_abnormal_chromosome_stability | 1.44081339 |
| 41 | MP0001879_abnormal_lymphatic_vessel | 1.43243608 |
| 42 | MP0004808_abnormal_hematopoietic_stem | 1.39375824 |
| 43 | MP0000465_gastrointestinal_hemorrhage | 1.38748240 |
| 44 | MP0009053_abnormal_anal_canal | 1.36463759 |
| 45 | MP0009250_abnormal_appendicular_skeleto | 1.31709433 |
| 46 | MP0005076_abnormal_cell_differentiation | 1.30612999 |
| 47 | MP0002877_abnormal_melanocyte_morpholog | 1.28574120 |
| 48 | MP0000750_abnormal_muscle_regeneration | 1.27677962 |
| 49 | MP0002396_abnormal_hematopoietic_system | 1.26174930 |
| 50 | MP0002019_abnormal_tumor_incidence | 1.26024075 |
| 51 | MP0002932_abnormal_joint_morphology | 1.24631264 |
| 52 | MP0003941_abnormal_skin_development | 1.24024959 |
| 53 | MP0000703_abnormal_thymus_morphology | 1.23065139 |
| 54 | MP0005501_abnormal_skin_physiology | 1.22649470 |
| 55 | MP0005451_abnormal_body_composition | 1.21830596 |
| 56 | MP0003453_abnormal_keratinocyte_physiol | 1.20957332 |
| 57 | MP0000613_abnormal_salivary_gland | 1.19840680 |
| 58 | MP0001348_abnormal_lacrimal_gland | 1.19363624 |
| 59 | MP0001873_stomach_inflammation | 1.18579770 |
| 60 | MP0005375_adipose_tissue_phenotype | 1.18103663 |
| 61 | MP0002295_abnormal_pulmonary_circulatio | 1.17458333 |
| 62 | MP0008007_abnormal_cellular_replicative | 1.17016105 |
| 63 | MP0003942_abnormal_urinary_system | 1.13371014 |
| 64 | MP0008058_abnormal_DNA_repair | 1.12158203 |
| 65 | MP0003436_decreased_susceptibility_to | 1.11670326 |
| 66 | MP0003115_abnormal_respiratory_system | 1.11369633 |
| 67 | MP0005621_abnormal_cell_physiology | 1.11013287 |
| 68 | MP0000428_abnormal_craniofacial_morphol | 1.10468371 |
| 69 | MP0002933_joint_inflammation | 1.09762773 |
| 70 | MP0002282_abnormal_trachea_morphology | 1.08829766 |
| 71 | MP0002108_abnormal_muscle_morphology | 1.08268264 |
| 72 | MP0002398_abnormal_bone_marrow | 1.05087238 |
| 73 | MP0004197_abnormal_fetal_growth/weight/ | 1.04281241 |
| 74 | MP0002132_abnormal_respiratory_system | 1.03151462 |
| 75 | MP0002925_abnormal_cardiovascular_devel | 1.02858824 |
| 76 | MP0001881_abnormal_mammary_gland | 1.02680711 |
| 77 | MP0000534_abnormal_ureter_morphology | 1.00294220 |
| 78 | MP0002128_abnormal_blood_circulation | 1.00228889 |
| 79 | MP0002249_abnormal_larynx_morphology | 1.00200219 |
| 80 | MP0001614_abnormal_blood_vessel | 0.99537069 |
| 81 | MP0002722_abnormal_immune_system | 0.99062502 |
| 82 | MP0005390_skeleton_phenotype | 0.98681903 |
| 83 | MP0000049_abnormal_middle_ear | 0.98323570 |
| 84 | MP0000858_altered_metastatic_potential | 0.97894404 |
| 85 | MP0001915_intracranial_hemorrhage | 0.96768057 |
| 86 | MP0002089_abnormal_postnatal_growth/wei | 0.95604989 |
| 87 | MP0010630_abnormal_cardiac_muscle | 0.95098268 |
| 88 | MP0004084_abnormal_cardiac_muscle | 0.94914549 |
| 89 | MP0000313_abnormal_cell_death | 0.93761658 |
| 90 | MP0002113_abnormal_skeleton_development | 0.92155970 |
| 91 | MP0001661_extended_life_span | 0.90634456 |
| 92 | MP0001542_abnormal_bone_strength | 0.90616399 |
| 93 | MP0003283_abnormal_digestive_organ | 0.90138775 |
| 94 | MP0003567_abnormal_fetal_cardiomyocyte | 0.89654465 |
| 95 | MP0000163_abnormal_cartilage_morphology | 0.89647455 |
| 96 | MP0001730_embryonic_growth_arrest | 0.87952543 |
| 97 | MP0002111_abnormal_tail_morphology | 0.87828281 |
| 98 | MP0002896_abnormal_bone_mineralization | 0.87580985 |
| 99 | MP0003077_abnormal_cell_cycle | 0.87419776 |
| 100 | MP0004233_abnormal_muscle_weight | 0.86861343 |
| 101 | MP0004957_abnormal_blastocyst_morpholog | 0.86121919 |
| 102 | MP0000350_abnormal_cell_proliferation | 0.85890881 |
| 103 | MP0003984_embryonic_growth_retardation | 0.85691983 |
| 104 | MP0002088_abnormal_embryonic_growth/wei | 0.85355112 |
| 105 | MP0003448_altered_tumor_morphology | 0.85222171 |
| 106 | MP0001175_abnormal_lung_morphology | 0.85024825 |
| 107 | MP0002085_abnormal_embryonic_tissue | 0.84744613 |
| 108 | MP0008932_abnormal_embryonic_tissue | 0.84489305 |
| 109 | MP0003935_abnormal_craniofacial_develop | 0.84220979 |
| 110 | MP0006138_congestive_heart_failure | 0.84126668 |
| 111 | MP0002086_abnormal_extraembryonic_tissu | 0.84046796 |
| 112 | MP0003806_abnormal_nucleotide_metabolis | 0.83838769 |
| 113 | MP0000537_abnormal_urethra_morphology | 0.83634922 |
| 114 | MP0001697_abnormal_embryo_size | 0.83328211 |
| 115 | MP0001672_abnormal_embryogenesis/_devel | 0.83309512 |
| 116 | MP0005380_embryogenesis_phenotype | 0.83309512 |
| 117 | MP0000762_abnormal_tongue_morphology | 0.81766986 |
| 118 | MP0010307_abnormal_tumor_latency | 0.81638460 |
| 119 | MP0003123_paternal_imprinting | 0.81363667 |
| 120 | MP0000751_myopathy | 0.80502562 |
| 121 | MP0002115_abnormal_skeleton_extremities | 0.80434234 |
| 122 | MP0002429_abnormal_blood_cell | 0.79151002 |
| 123 | MP0005666_abnormal_adipose_tissue | 0.78739060 |
| 124 | MP0002084_abnormal_developmental_patter | 0.78395095 |
| 125 | MP0000759_abnormal_skeletal_muscle | 0.77766940 |
| 126 | MP0005464_abnormal_platelet_physiology | 0.77755662 |
| 127 | MP0003937_abnormal_limbs/digits/tail_de | 0.77653121 |
| 128 | MP0001299_abnormal_eye_distance/ | 0.77358956 |
| 129 | MP0003755_abnormal_palate_morphology | 0.77149143 |
| 130 | MP0000266_abnormal_heart_morphology | 0.76237143 |
| 131 | MP0000689_abnormal_spleen_morphology | 0.75922891 |
| 132 | MP0004087_abnormal_muscle_fiber | 0.75636699 |
| 133 | MP0009278_abnormal_bone_marrow | 0.74664420 |
| 134 | MP0000566_synostosis | 0.74581287 |
| 135 | MP0000003_abnormal_adipose_tissue | 0.73097158 |
| 136 | MP0002080_prenatal_lethality | 0.72936657 |
| 137 | MP0000013_abnormal_adipose_tissue | 0.72889345 |
| 138 | MP0000432_abnormal_head_morphology | 0.71572492 |
| 139 | MP0005084_abnormal_gallbladder_morpholo | 0.71414542 |
| 140 | MP0000749_muscle_degeneration | 0.68852473 |
| 141 | MP0005367_renal/urinary_system_phenotyp | 0.68589311 |
| 142 | MP0000516_abnormal_urinary_system | 0.68589311 |
| 143 | MP0003300_gastrointestinal_ulcer | 0.68560099 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 8.45771916 |
| 2 | Premature rupture of membranes (HP:0001788) | 6.87777489 |
| 3 | Shallow orbits (HP:0000586) | 4.95612634 |
| 4 | Ankle contracture (HP:0006466) | 4.87258516 |
| 5 | Aortic dissection (HP:0002647) | 4.54090624 |
| 6 | Peritonitis (HP:0002586) | 4.21164905 |
| 7 | Broad metatarsal (HP:0001783) | 4.18949740 |
| 8 | Cerebral aneurysm (HP:0004944) | 4.14123560 |
| 9 | Soft skin (HP:0000977) | 4.01584881 |
| 10 | Aortic aneurysm (HP:0004942) | 3.91005718 |
| 11 | Cervical subluxation (HP:0003308) | 3.80122936 |
| 12 | Achilles tendon contracture (HP:0001771) | 3.78993329 |
| 13 | Dilatation of the ascending aorta (HP:0005111) | 3.78748194 |
| 14 | Vertebral compression fractures (HP:0002953) | 3.76058008 |
| 15 | Atrophic scars (HP:0001075) | 3.62778884 |
| 16 | Bladder diverticulum (HP:0000015) | 3.60955370 |
| 17 | Abnormality of dentin (HP:0010299) | 3.53841370 |
| 18 | Wrist flexion contracture (HP:0001239) | 3.48573894 |
| 19 | Rectal prolapse (HP:0002035) | 3.47488799 |
| 20 | Biconcave vertebral bodies (HP:0004586) | 3.41092946 |
| 21 | Fragile skin (HP:0001030) | 3.32519885 |
| 22 | Genu recurvatum (HP:0002816) | 3.28065515 |
| 23 | Abnormality of the Achilles tendon (HP:0005109) | 3.21833139 |
| 24 | Increased connective tissue (HP:0009025) | 3.17847938 |
| 25 | Type 1 muscle fiber predominance (HP:0003803) | 3.17556979 |
| 26 | Spinal rigidity (HP:0003306) | 3.12923640 |
| 27 | Blue sclerae (HP:0000592) | 3.08182418 |
| 28 | Neonatal short-limb short stature (HP:0008921) | 3.05746528 |
| 29 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.03103601 |
| 30 | Mitral valve prolapse (HP:0001634) | 3.02833786 |
| 31 | Broad distal phalanx of finger (HP:0009836) | 2.99792041 |
| 32 | Hyperacusis (HP:0010780) | 2.96358179 |
| 33 | Wormian bones (HP:0002645) | 2.91600757 |
| 34 | Bowel diverticulosis (HP:0005222) | 2.90207241 |
| 35 | Short 4th metacarpal (HP:0010044) | 2.87252815 |
| 36 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.87252815 |
| 37 | Cellulitis (HP:0100658) | 2.84668083 |
| 38 | Progressive muscle weakness (HP:0003323) | 2.77635524 |
| 39 | Premature skin wrinkling (HP:0100678) | 2.73632809 |
| 40 | Increased density of long bones (HP:0006392) | 2.71916538 |
| 41 | Follicular hyperkeratosis (HP:0007502) | 2.53532387 |
| 42 | Patent foramen ovale (HP:0001655) | 2.52962017 |
| 43 | Nonimmune hydrops fetalis (HP:0001790) | 2.51555526 |
| 44 | Thin bony cortex (HP:0002753) | 2.51059295 |
| 45 | Abnormality of the acetabulum (HP:0003170) | 2.50784872 |
| 46 | Abnormality of the peritoneum (HP:0002585) | 2.49376795 |
| 47 | Selective tooth agenesis (HP:0001592) | 2.47296500 |
| 48 | Ragged-red muscle fibers (HP:0003200) | 2.46155133 |
| 49 | Round ear (HP:0100830) | 2.45971566 |
| 50 | Camptodactyly of toe (HP:0001836) | 2.42438215 |
| 51 | Aneurysm (HP:0002617) | 2.42354094 |
| 52 | Abnormal delivery (HP:0001787) | 2.36107025 |
| 53 | Elbow flexion contracture (HP:0002987) | 2.35764625 |
| 54 | Pseudobulbar signs (HP:0002200) | 2.35366375 |
| 55 | Slender build (HP:0001533) | 2.29195840 |
| 56 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.27388874 |
| 57 | Abnormality of the 4th metacarpal (HP:0010012) | 2.26975429 |
| 58 | Hyperextensible skin (HP:0000974) | 2.26839986 |
| 59 | Aortic regurgitation (HP:0001659) | 2.26042040 |
| 60 | Mesomelia (HP:0003027) | 2.25740716 |
| 61 | Syringomyelia (HP:0003396) | 2.24309786 |
| 62 | Spinal cord lesions (HP:0100561) | 2.24309786 |
| 63 | Breech presentation (HP:0001623) | 2.20570520 |
| 64 | Abnormality of the calcaneus (HP:0008364) | 2.19956596 |
| 65 | Microretrognathia (HP:0000308) | 2.19378234 |
| 66 | Abnormality of the umbilical cord (HP:0010881) | 2.18836368 |
| 67 | Deviation of the hallux (HP:0010051) | 2.16021856 |
| 68 | Vascular tortuosity (HP:0004948) | 2.14042970 |
| 69 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.13386655 |
| 70 | Redundant skin (HP:0001582) | 2.12263819 |
| 71 | Mitral regurgitation (HP:0001653) | 2.08474953 |
| 72 | Hallux valgus (HP:0001822) | 2.08244058 |
| 73 | Microvesicular hepatic steatosis (HP:0001414) | 2.05937098 |
| 74 | Atelectasis (HP:0100750) | 2.05881120 |
| 75 | Bell-shaped thorax (HP:0001591) | 2.05261871 |
| 76 | Increased variability in muscle fiber diameter (HP:0003557) | 2.04473880 |
| 77 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.03486374 |
| 78 | Overgrowth (HP:0001548) | 2.03469922 |
| 79 | Broad face (HP:0000283) | 2.03209053 |
| 80 | Slender long bone (HP:0003100) | 2.03002375 |
| 81 | Eczematoid dermatitis (HP:0000976) | 2.02503569 |
| 82 | Wide anterior fontanel (HP:0000260) | 2.00680801 |
| 83 | Joint laxity (HP:0001388) | 2.00210253 |
| 84 | Flexion contracture of toe (HP:0005830) | 2.00070547 |
| 85 | Joint contractures involving the joints of the feet (HP:0100492) | 2.00070547 |
| 86 | Trismus (HP:0000211) | 1.97953099 |
| 87 | Distal upper limb amyotrophy (HP:0007149) | 1.96141964 |
| 88 | Upper limb amyotrophy (HP:0009129) | 1.96141964 |
| 89 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.96076070 |
| 90 | Renal duplication (HP:0000075) | 1.96045219 |
| 91 | Pulmonary artery stenosis (HP:0004415) | 1.94327484 |
| 92 | Radial bowing (HP:0002986) | 1.92483230 |
| 93 | Hypertensive crisis (HP:0100735) | 1.91903959 |
| 94 | Ectopia lentis (HP:0001083) | 1.91634171 |
| 95 | Hypertriglyceridemia (HP:0002155) | 1.91403430 |
| 96 | Agammaglobulinemia (HP:0004432) | 1.90767901 |
| 97 | Abnormality of the tricuspid valve (HP:0001702) | 1.90085561 |
| 98 | Difficulty climbing stairs (HP:0003551) | 1.89472177 |
| 99 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.89297619 |
| 100 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.89297619 |
| 101 | Single umbilical artery (HP:0001195) | 1.89297619 |
| 102 | Knee flexion contracture (HP:0006380) | 1.89161476 |
| 103 | Partial duplication of the phalanx of hand (HP:0009999) | 1.87201647 |
| 104 | Abnormality of the thoracic spine (HP:0100711) | 1.86912630 |
| 105 | Ulnar bowing (HP:0003031) | 1.86448082 |
| 106 | Arterial tortuosity (HP:0005116) | 1.85390015 |
| 107 | Generalized amyotrophy (HP:0003700) | 1.80236338 |
| 108 | Calcaneovalgus deformity (HP:0001848) | 1.80130590 |
| 109 | Scapular winging (HP:0003691) | 1.80041102 |
| 110 | Patellar dislocation (HP:0002999) | 1.79299534 |
| 111 | Dysphonia (HP:0001618) | 1.79166796 |
| 112 | High pitched voice (HP:0001620) | 1.76364102 |
| 113 | Coxa vara (HP:0002812) | 1.75897757 |
| 114 | Thrombocytosis (HP:0001894) | 1.75708670 |
| 115 | Osteopenia (HP:0000938) | 1.75539953 |
| 116 | Hydroureter (HP:0000072) | 1.74431943 |
| 117 | Striae distensae (HP:0001065) | 1.74254102 |
| 118 | Absent epiphyses (HP:0010577) | 1.73191923 |
| 119 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.73191923 |
| 120 | Bowed forearm bones (HP:0003956) | 1.73125228 |
| 121 | Bowing of the arm (HP:0006488) | 1.73125228 |
| 122 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.73020642 |
| 123 | Fatigue (HP:0012378) | 1.72769282 |
| 124 | Cupped ribs (HP:0000887) | 1.72750274 |
| 125 | Delayed cranial suture closure (HP:0000270) | 1.72289796 |
| 126 | Broad long bones (HP:0005622) | 1.71822795 |
| 127 | Reticulocytopenia (HP:0001896) | 1.71476480 |
| 128 | Hip contracture (HP:0003273) | 1.70914123 |
| 129 | Testicular atrophy (HP:0000029) | 1.70868175 |
| 130 | Decreased skull ossification (HP:0004331) | 1.70267277 |
| 131 | Infantile muscular hypotonia (HP:0008947) | 1.70097177 |
| 132 | Osteolytic defects of the hand bones (HP:0009699) | 1.69784678 |
| 133 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.69784678 |
| 134 | Aortic valve stenosis (HP:0001650) | 1.69599779 |
| 135 | Emphysema (HP:0002097) | 1.69466574 |
| 136 | Severe visual impairment (HP:0001141) | 1.67138049 |
| 137 | Bicuspid aortic valve (HP:0001647) | 1.66723341 |
| 138 | Buphthalmos (HP:0000557) | 1.66281785 |
| 139 | Inguinal hernia (HP:0000023) | 1.66119081 |
| 140 | Long palpebral fissure (HP:0000637) | 1.65682264 |
| 141 | Hand muscle atrophy (HP:0009130) | 1.65403603 |
| 142 | Hypercortisolism (HP:0001578) | 1.64911408 |
| 143 | Venous abnormality (HP:0002624) | 1.64304431 |
| 144 | Partial duplication of thumb phalanx (HP:0009944) | 1.63977113 |
| 145 | Joint stiffness (HP:0001387) | 1.63854133 |
| 146 | Broad hallux (HP:0010055) | 1.63786864 |
| 147 | Thoracic kyphosis (HP:0002942) | 1.63394641 |
| 148 | Venous insufficiency (HP:0005293) | 1.62144142 |
| 149 | Short nail (HP:0001799) | 1.61940847 |
| 150 | Deformed tarsal bones (HP:0008119) | 1.60536708 |
| 151 | Abnormality of the anterior chamber (HP:0000593) | 1.59863563 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 3.66803469 |
| 2 | TTN | 3.60047325 |
| 3 | PKN2 | 3.34638184 |
| 4 | SMG1 | 3.22022586 |
| 5 | PRPF4B | 2.81297713 |
| 6 | DDR2 | 2.78257356 |
| 7 | LATS2 | 2.75546558 |
| 8 | KDR | 2.50709843 |
| 9 | PDGFRA | 2.47993709 |
| 10 | TGFBR1 | 2.24049421 |
| 11 | TESK2 | 2.18540433 |
| 12 | MAP3K10 | 2.05070458 |
| 13 | TGFBR2 | 2.01568119 |
| 14 | NME2 | 1.96886578 |
| 15 | VRK2 | 1.95941506 |
| 16 | MAP4K1 | 1.92314008 |
| 17 | FLT3 | 1.87821330 |
| 18 | BCKDK | 1.87163598 |
| 19 | EEF2K | 1.83570278 |
| 20 | RPS6KA4 | 1.83082893 |
| 21 | TESK1 | 1.82827185 |
| 22 | PAK4 | 1.81912141 |
| 23 | LRRK2 | 1.80912119 |
| 24 | PAK2 | 1.75487190 |
| 25 | ERN1 | 1.68869643 |
| 26 | WEE1 | 1.68802304 |
| 27 | RIPK1 | 1.68727977 |
| 28 | IRAK3 | 1.59325611 |
| 29 | EPHA2 | 1.55875303 |
| 30 | LATS1 | 1.50762716 |
| 31 | MAP2K3 | 1.43298450 |
| 32 | ABL2 | 1.42963062 |
| 33 | TIE1 | 1.42463587 |
| 34 | ILK | 1.42160128 |
| 35 | STK10 | 1.34466737 |
| 36 | MYLK | 1.31806790 |
| 37 | EPHB2 | 1.31294405 |
| 38 | BUB1 | 1.30950876 |
| 39 | CDK8 | 1.29980832 |
| 40 | SIK1 | 1.28736749 |
| 41 | PTK6 | 1.26893928 |
| 42 | LIMK1 | 1.23391235 |
| 43 | ARAF | 1.20907980 |
| 44 | SCYL2 | 1.18838334 |
| 45 | ICK | 1.17765850 |
| 46 | PTK2 | 1.17534830 |
| 47 | TRPM7 | 1.16109239 |
| 48 | RPS6KB2 | 1.14022212 |
| 49 | KIT | 1.10731743 |
| 50 | RPS6KL1 | 1.10467436 |
| 51 | RPS6KC1 | 1.10467436 |
| 52 | MAP3K11 | 1.07583828 |
| 53 | MOS | 1.06980440 |
| 54 | DMPK | 1.05724599 |
| 55 | MUSK | 1.04431999 |
| 56 | BMX | 1.03251768 |
| 57 | MAP3K8 | 1.02830835 |
| 58 | TLK1 | 1.00922048 |
| 59 | NEK2 | 1.00742795 |
| 60 | MAPK11 | 0.99116307 |
| 61 | BRSK2 | 0.94446659 |
| 62 | PIM2 | 0.93839416 |
| 63 | CDK7 | 0.92634420 |
| 64 | MAPKAPK3 | 0.92154954 |
| 65 | MTOR | 0.91434362 |
| 66 | FGFR1 | 0.91022555 |
| 67 | MAP3K3 | 0.90164478 |
| 68 | PTK2B | 0.89116640 |
| 69 | RPS6KA6 | 0.87605643 |
| 70 | PAK1 | 0.85356837 |
| 71 | CDC7 | 0.84607545 |
| 72 | CDK12 | 0.84136607 |
| 73 | FER | 0.83324019 |
| 74 | DAPK3 | 0.82519223 |
| 75 | STK38L | 0.79693050 |
| 76 | ZAP70 | 0.74807636 |
| 77 | NEK9 | 0.74133200 |
| 78 | IRAK4 | 0.73768980 |
| 79 | PDGFRB | 0.72205023 |
| 80 | JAK3 | 0.71980136 |
| 81 | DYRK3 | 0.71829534 |
| 82 | IRAK2 | 0.70374167 |
| 83 | STK3 | 0.68333870 |
| 84 | MAP3K13 | 0.67729126 |
| 85 | CDK6 | 0.67693337 |
| 86 | MAP2K2 | 0.66659956 |
| 87 | ROCK1 | 0.63897443 |
| 88 | MKNK1 | 0.62204998 |
| 89 | EPHA3 | 0.61024095 |
| 90 | AURKB | 0.59959091 |
| 91 | STK4 | 0.59873680 |
| 92 | TAF1 | 0.59834311 |
| 93 | GRK6 | 0.58202089 |
| 94 | PIK3CA | 0.56531058 |
| 95 | CDK4 | 0.56090038 |
| 96 | NEK1 | 0.55825112 |
| 97 | PASK | 0.54613581 |
| 98 | ACVR1B | 0.54344269 |
| 99 | FGFR4 | 0.54282159 |
| 100 | PBK | 0.53690740 |
| 101 | PRKD3 | 0.53396455 |
| 102 | BRAF | 0.53219967 |
| 103 | PAK3 | 0.51457168 |
| 104 | CHEK1 | 0.49824963 |
| 105 | MAPK15 | 0.49434980 |
| 106 | AURKA | 0.48416285 |
| 107 | MET | 0.48315791 |
| 108 | CDK9 | 0.47653933 |
| 109 | MAPK4 | 0.47600727 |
| 110 | ATR | 0.47381961 |
| 111 | CSF1R | 0.47363147 |
| 112 | MST1R | 0.47028933 |
| 113 | TBK1 | 0.46186511 |
| 114 | EIF2AK1 | 0.45666670 |
| 115 | PIK3CG | 0.44871614 |
| 116 | MAP3K1 | 0.43451933 |
| 117 | PLK1 | 0.43129764 |
| 118 | TAOK2 | 0.42049176 |
| 119 | PRKD2 | 0.41524941 |
| 120 | MAPKAPK2 | 0.41286889 |
| 121 | RPS6KA2 | 0.41134252 |
| 122 | MAPK12 | 0.40976589 |
| 123 | MAP3K7 | 0.40808318 |
| 124 | MARK2 | 0.40736356 |
| 125 | ROCK2 | 0.40305205 |
| 126 | MAP2K1 | 0.40268002 |
| 127 | AKT2 | 0.40022344 |
| 128 | RPS6KA1 | 0.38646832 |
| 129 | CDK2 | 0.38517936 |
| 130 | PRKG2 | 0.38394734 |
| 131 | TYK2 | 0.37782980 |
| 132 | TTK | 0.36060660 |
| 133 | MAPK7 | 0.35921377 |
| 134 | PRKD1 | 0.34994835 |
| 135 | CDC42BPA | 0.34431231 |
| 136 | INSR | 0.34226663 |
| 137 | IKBKE | 0.33800793 |
| 138 | BTK | 0.33245097 |
| 139 | HIPK2 | 0.32994512 |
| 140 | EPHB1 | 0.32795706 |
| 141 | CCNB1 | 0.32764633 |
| 142 | RET | 0.30531316 |
| 143 | CHEK2 | 0.29827068 |
| 144 | SRPK1 | 0.29510566 |
| 145 | TAOK1 | 0.29349656 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.75723014 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 2.66620025 |
| 3 | Focal adhesion_Homo sapiens_hsa04510 | 2.43993089 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.26193802 |
| 5 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 2.19290216 |
| 6 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.07255920 |
| 7 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.01784624 |
| 8 | Bladder cancer_Homo sapiens_hsa05219 | 2.00332876 |
| 9 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.90833510 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.89102813 |
| 11 | Adherens junction_Homo sapiens_hsa04520 | 1.83622316 |
| 12 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.82704593 |
| 13 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.81696890 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 1.77484408 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 1.76429682 |
| 16 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.70903734 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.68536434 |
| 18 | Mismatch repair_Homo sapiens_hsa03430 | 1.63232838 |
| 19 | Shigellosis_Homo sapiens_hsa05131 | 1.62707174 |
| 20 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.61752534 |
| 21 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.58772569 |
| 22 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.58133821 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.56838513 |
| 24 | Viral myocarditis_Homo sapiens_hsa05416 | 1.56405176 |
| 25 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.54752899 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.51622596 |
| 27 | HTLV-I infection_Homo sapiens_hsa05166 | 1.44817081 |
| 28 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.43138554 |
| 29 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.42322531 |
| 30 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.41872708 |
| 31 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.40659059 |
| 32 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.40006124 |
| 33 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.39076724 |
| 34 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.35489495 |
| 35 | Amoebiasis_Homo sapiens_hsa05146 | 1.35405597 |
| 36 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.34704993 |
| 37 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.29738440 |
| 38 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.28815033 |
| 39 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.28726139 |
| 40 | Base excision repair_Homo sapiens_hsa03410 | 1.27818804 |
| 41 | Malaria_Homo sapiens_hsa05144 | 1.25933465 |
| 42 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.24898725 |
| 43 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.23472061 |
| 44 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.20575077 |
| 45 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.20446779 |
| 46 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.18303776 |
| 47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.15692365 |
| 48 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.15262594 |
| 49 | Pathways in cancer_Homo sapiens_hsa05200 | 1.13500260 |
| 50 | Apoptosis_Homo sapiens_hsa04210 | 1.11472175 |
| 51 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.07471462 |
| 52 | Thyroid cancer_Homo sapiens_hsa05216 | 1.06815841 |
| 53 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.05503348 |
| 54 | Melanoma_Homo sapiens_hsa05218 | 1.02653679 |
| 55 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.99937134 |
| 56 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.99370761 |
| 57 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.99007031 |
| 58 | Purine metabolism_Homo sapiens_hsa00230 | 0.98725509 |
| 59 | Proteasome_Homo sapiens_hsa03050 | 0.97805644 |
| 60 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.96804755 |
| 61 | Platelet activation_Homo sapiens_hsa04611 | 0.96279750 |
| 62 | Colorectal cancer_Homo sapiens_hsa05210 | 0.94841483 |
| 63 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.93405945 |
| 64 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.92478253 |
| 65 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.91495257 |
| 66 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.89574750 |
| 67 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.87603817 |
| 68 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.86487575 |
| 69 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.85926995 |
| 70 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.84778403 |
| 71 | Hepatitis B_Homo sapiens_hsa05161 | 0.83846107 |
| 72 | Prostate cancer_Homo sapiens_hsa05215 | 0.83460502 |
| 73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.82817926 |
| 74 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.82577095 |
| 75 | Tight junction_Homo sapiens_hsa04530 | 0.82015144 |
| 76 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.80790125 |
| 77 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.80121310 |
| 78 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.78947347 |
| 79 | Salmonella infection_Homo sapiens_hsa05132 | 0.78633065 |
| 80 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.78168292 |
| 81 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.73912459 |
| 82 | Leishmaniasis_Homo sapiens_hsa05140 | 0.73431852 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.73317526 |
| 84 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.70192602 |
| 85 | Homologous recombination_Homo sapiens_hsa03440 | 0.69913003 |
| 86 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.69844138 |
| 87 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.68966615 |
| 88 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.68080896 |
| 89 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.67738769 |
| 90 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.64830913 |
| 91 | Glioma_Homo sapiens_hsa05214 | 0.64044880 |
| 92 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.63446528 |
| 93 | RNA polymerase_Homo sapiens_hsa03020 | 0.62545320 |
| 94 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.61473575 |
| 95 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.60697483 |
| 96 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.59025417 |
| 97 | RNA degradation_Homo sapiens_hsa03018 | 0.58459860 |
| 98 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.58384940 |
| 99 | Measles_Homo sapiens_hsa05162 | 0.58095301 |
| 100 | Legionellosis_Homo sapiens_hsa05134 | 0.57431242 |
| 101 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.56958414 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.55231999 |
| 103 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.54994679 |
| 104 | Sulfur relay system_Homo sapiens_hsa04122 | 0.51745388 |
| 105 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.50402739 |
| 106 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.49660622 |
| 107 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.49385307 |
| 108 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.48904548 |
| 109 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.48877948 |
| 110 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.48836417 |
| 111 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.47007107 |
| 112 | Carbon metabolism_Homo sapiens_hsa01200 | 0.46527930 |
| 113 | Endocytosis_Homo sapiens_hsa04144 | 0.45809815 |
| 114 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.44969221 |
| 115 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.44852493 |
| 116 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.44728280 |
| 117 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.44723929 |
| 118 | Endometrial cancer_Homo sapiens_hsa05213 | 0.44345719 |
| 119 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.43435355 |
| 120 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.42795039 |
| 121 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.41263192 |
| 122 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.40902171 |
| 123 | Hepatitis C_Homo sapiens_hsa05160 | 0.36701856 |
| 124 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.35741355 |

