CCDC105

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.90936160
2epithelial cilium movement (GO:0003351)9.88296078
3reproduction (GO:0000003)9.54835705
4motile cilium assembly (GO:0044458)9.26103640
5spermatid development (GO:0007286)9.20257375
6piRNA metabolic process (GO:0034587)8.47016014
7cilium movement (GO:0003341)8.25171600
8regulation of cilium movement (GO:0003352)8.20321181
9male meiosis (GO:0007140)7.82091125
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.74965425
11single fertilization (GO:0007338)7.60567616
12synaptonemal complex organization (GO:0070193)7.37808742
13synaptonemal complex assembly (GO:0007130)7.28125428
14sperm capacitation (GO:0048240)6.99604159
15fertilization (GO:0009566)6.55778152
16negative regulation of inclusion body assembly (GO:0090084)6.41569512
17spermatogenesis (GO:0007283)6.31258097
18male gamete generation (GO:0048232)6.28970102
19microtubule depolymerization (GO:0007019)6.26018279
20gamete generation (GO:0007276)5.85788625
21organic cation transport (GO:0015695)5.79106566
22DNA methylation involved in gamete generation (GO:0043046)5.53240310
23calcium ion-dependent exocytosis (GO:0017156)5.35479509
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.32650603
25germ cell development (GO:0007281)5.32050607
26microtubule severing (GO:0051013)5.30922530
27regulation of inclusion body assembly (GO:0090083)5.30782552
28ventricular system development (GO:0021591)5.22729849
29cell recognition (GO:0008037)5.03138276
30chromosome organization involved in meiosis (GO:0070192)5.01057023
31male meiosis I (GO:0007141)4.95098034
32regulation of microtubule-based movement (GO:0060632)4.74199799
33multicellular organismal reproductive process (GO:0048609)4.63168951
34spermatid nucleus differentiation (GO:0007289)4.47633860
35meiotic nuclear division (GO:0007126)4.47461530
36seminiferous tubule development (GO:0072520)4.31838984
37chromosome condensation (GO:0030261)4.30840539
38glycerol ether metabolic process (GO:0006662)4.12821885
39left/right pattern formation (GO:0060972)4.08374361
40DNA packaging (GO:0006323)4.06950885
41meiotic cell cycle (GO:0051321)4.01067408
42meiosis I (GO:0007127)3.95947592
43protein polyglutamylation (GO:0018095)3.95025074
44ether metabolic process (GO:0018904)3.80869864
45protein localization to cilium (GO:0061512)3.79956696
46monoubiquitinated protein deubiquitination (GO:0035520)3.79762665
47multicellular organismal development (GO:0007275)3.67825032
48chaperone-mediated protein complex assembly (GO:0051131)3.59513706
49genitalia morphogenesis (GO:0035112)3.49377728
50protein K11-linked deubiquitination (GO:0035871)3.34014369
51single strand break repair (GO:0000012)3.31368558
52microtubule polymerization or depolymerization (GO:0031109)3.30871182
53regulation of spindle checkpoint (GO:0090231)3.11558364
54intraciliary transport (GO:0042073)3.09290053
55cilium organization (GO:0044782)3.08941681
56gene silencing by RNA (GO:0031047)3.06453292
57nucleoside diphosphate phosphorylation (GO:0006165)3.04182752
58microtubule-based movement (GO:0007018)3.03298395
59meiotic cell cycle process (GO:1903046)3.01864384
60regulation of acrosome reaction (GO:0060046)3.01666561
61polyol catabolic process (GO:0046174)3.01518721
62cilium assembly (GO:0042384)2.99789497
63lactate metabolic process (GO:0006089)2.98119382
64negative regulation of organelle assembly (GO:1902116)2.93787842
65sequestering of actin monomers (GO:0042989)2.92846222
66cilium morphogenesis (GO:0060271)2.92664160
67glycolytic process (GO:0006096)2.92569706
68axoneme assembly (GO:0035082)2.91787751
69synapsis (GO:0007129)2.89452826
70amino-acid betaine transport (GO:0015838)2.89445253
71carnitine transport (GO:0015879)2.89445253
72cellular component assembly involved in morphogenesis (GO:0010927)2.87858969
73sexual reproduction (GO:0019953)2.86368756
74protein refolding (GO:0042026)2.86009953
75GTP biosynthetic process (GO:0006183)2.84896852
76alditol metabolic process (GO:0019400)2.83431882
77mitotic sister chromatid cohesion (GO:0007064)2.81426465
78nucleus organization (GO:0006997)2.78184422
79centriole assembly (GO:0098534)2.76245386
80carnitine transmembrane transport (GO:1902603)2.75630801
81RNA localization (GO:0006403)2.61396849
82interferon-gamma secretion (GO:0072643)2.61011893
83peptidyl-glutamic acid modification (GO:0018200)2.59151017
84regulation of cilium assembly (GO:1902017)2.56653000
85regulation of centriole replication (GO:0046599)2.54528440
86regulation of meiosis I (GO:0060631)2.53893214
87RNA destabilization (GO:0050779)2.51480917
88centriole replication (GO:0007099)2.50223891
89fusion of sperm to egg plasma membrane (GO:0007342)13.1148468
90sperm motility (GO:0030317)12.7843273
91cell wall macromolecule catabolic process (GO:0016998)12.5202795
92cell wall macromolecule metabolic process (GO:0044036)12.5202795
93multicellular organism reproduction (GO:0032504)11.4582626
94sperm-egg recognition (GO:0035036)11.3719292
95acrosome assembly (GO:0001675)11.3178560
96acrosome reaction (GO:0007340)11.1607485
97binding of sperm to zona pellucida (GO:0007339)10.4123210
98cilium or flagellum-dependent cell motility (GO:0001539)10.3988176
99plasma membrane fusion (GO:0045026)10.1990947
100cell-cell recognition (GO:0009988)10.1425801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.74541681
2EZH2_22144423_ChIP-Seq_EOC_Human5.41306305
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.37606458
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.18806647
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07466152
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60482725
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39117711
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.36615557
9VDR_22108803_ChIP-Seq_LS180_Human2.30201668
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21614559
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08296392
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06978137
13ZNF274_21170338_ChIP-Seq_K562_Hela2.00904333
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.92458556
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92177915
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.87649635
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86187610
18TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73662165
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69658926
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68325690
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.67714412
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.66827555
23STAT1_17558387_ChIP-Seq_HELA_Human1.66340071
24KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60886912
25KDM2B_26808549_Chip-Seq_REH_Human1.57190905
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56573209
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53642840
28TAL1_26923725_Chip-Seq_HPCs_Mouse1.51621214
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.50629341
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.48305093
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48218563
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44881087
33CBP_20019798_ChIP-Seq_JUKART_Human1.44508763
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44508763
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44060419
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43279302
37REST_21632747_ChIP-Seq_MESCs_Mouse1.42813256
38* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41957037
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37244818
40* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36056197
41GATA3_21867929_ChIP-Seq_CD8_Mouse1.35799264
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35390170
43TAF15_26573619_Chip-Seq_HEK293_Human1.32359455
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.31655296
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.30425139
46RNF2_27304074_Chip-Seq_NSC_Mouse1.26161124
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24424952
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22830266
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22830266
50* GATA3_21867929_ChIP-Seq_TH1_Mouse1.21609634
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21241692
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.20258852
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19113447
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17852098
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17694048
56OCT4_18555785_Chip-Seq_ESCs_Mouse1.17154977
57P53_22387025_ChIP-Seq_ESCs_Mouse1.17052405
58RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15833462
59GF1_26923725_Chip-Seq_HPCs_Mouse1.15009392
60SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14592448
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14267674
62* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13525157
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13087800
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11901626
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.11657010
66P53_21459846_ChIP-Seq_SAOS-2_Human1.11552192
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.11073592
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08761206
69CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07198291
70P300_18555785_Chip-Seq_ESCs_Mouse1.06731579
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06456218
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.05755779
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05749532
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04597715
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03584153
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03461566
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02616231
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.01805474
79ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01619799
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01466770
81FUS_26573619_Chip-Seq_HEK293_Human1.00361847
82SOX2_18555785_Chip-Seq_ESCs_Mouse0.96675696
83ESET_19884257_ChIP-Seq_ESCs_Mouse0.96365564
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95745178
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94561028
86E2F1_18555785_Chip-Seq_ESCs_Mouse0.94224035
87ERG_20517297_ChIP-Seq_VCAP_Human0.93150235
88PU1_27457419_Chip-Seq_LIVER_Mouse0.92626736
89SPI1_26923725_Chip-Seq_HPCs_Mouse0.92500653
90TBL1_22424771_ChIP-Seq_293T_Human0.92435659
91CTCF_18555785_Chip-Seq_ESCs_Mouse0.91848251
92SOX9_26525672_Chip-Seq_HEART_Mouse0.91498326
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90471775
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90450358
95* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90260143
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.89811338
97NFYB_21822215_ChIP-Seq_K562_Human0.89806226
98GF1B_26923725_Chip-Seq_HPCs_Mouse0.89575559
99STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88452415
100NMYC_18555785_Chip-Seq_ESCs_Mouse0.87476373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.85048047
2MP0001929_abnormal_gametogenesis5.55732824
3MP0008877_abnormal_DNA_methylation4.89143705
4MP0002210_abnormal_sex_determination3.57178342
5MP0002161_abnormal_fertility/fecundity3.32918012
6MP0002653_abnormal_ependyma_morphology3.00163456
7MP0001145_abnormal_male_reproductive2.96305862
8MP0000653_abnormal_sex_gland2.72721766
9MP0005670_abnormal_white_adipose2.46379918
10MP0003646_muscle_fatigue2.37164083
11MP0005410_abnormal_fertilization15.1880544
12MP0002160_abnormal_reproductive_system1.67419442
13MP0005623_abnormal_meninges_morphology1.47446293
14MP0009046_muscle_twitch1.43921102
15MP0002282_abnormal_trachea_morphology1.32738983
16MP0001984_abnormal_olfaction1.30116212
17MP0003787_abnormal_imprinting1.26039010
18MP0004233_abnormal_muscle_weight1.24185795
19MP0005389_reproductive_system_phenotype0.99564795
20MP0008058_abnormal_DNA_repair0.96486700
21MP0001765_abnormal_ion_homeostasis0.96436532
22MP0005647_abnormal_sex_gland0.96022195
23MP0002736_abnormal_nociception_after0.93160947
24MP0003699_abnormal_female_reproductive0.88751393
25MP0008995_early_reproductive_senescence0.87636272
26MP0002102_abnormal_ear_morphology0.86767930
27MP0003718_maternal_effect0.86664028
28MP0010094_abnormal_chromosome_stability0.86634384
29MP0001968_abnormal_touch/_nociception0.78813606
30MP0003880_abnormal_central_pattern0.78214881
31MP0001529_abnormal_vocalization0.78146747
32MP0008057_abnormal_DNA_replication0.77229831
33MP0001119_abnormal_female_reproductive0.69232265
34MP0002234_abnormal_pharynx_morphology0.66472566
35MP0003011_delayed_dark_adaptation0.66197533
36MP0004036_abnormal_muscle_relaxation0.62220220
37MP0003115_abnormal_respiratory_system0.60237911
38MP0002572_abnormal_emotion/affect_behav0.60131769
39MP0005646_abnormal_pituitary_gland0.60113829
40MP0002822_catalepsy0.57408173
41MP0003329_amyloid_beta_deposits0.55291922
42MP0003879_abnormal_hair_cell0.54147292
43MP0000569_abnormal_digit_pigmentation0.53906177
44MP0003635_abnormal_synaptic_transmissio0.50784004
45MP0006276_abnormal_autonomic_nervous0.47994625
46MP0001440_abnormal_grooming_behavior0.47922422
47MP0005551_abnormal_eye_electrophysiolog0.47544262
48MP0000358_abnormal_cell_content/0.47303977
49MP0003786_premature_aging0.46007941
50MP0008007_abnormal_cellular_replicative0.45173462
51MP0004859_abnormal_synaptic_plasticity0.44848681
52MP0002063_abnormal_learning/memory/cond0.44644816
53MP0005636_abnormal_mineral_homeostasis0.43361318
54MP0003111_abnormal_nucleus_morphology0.43068105
55MP0004270_analgesia0.42900910
56MP0001905_abnormal_dopamine_level0.41743768
57MP0003950_abnormal_plasma_membrane0.40451149
58MP0009745_abnormal_behavioral_response0.40369666
59MP0002272_abnormal_nervous_system0.40346284
60MP0004145_abnormal_muscle_electrophysio0.39682022
61MP0005253_abnormal_eye_physiology0.38881651
62MP0002557_abnormal_social/conspecific_i0.38132723
63MP0003861_abnormal_nervous_system0.37556926
64MP0003878_abnormal_ear_physiology0.37172150
65MP0005377_hearing/vestibular/ear_phenot0.37172150
66MP0002152_abnormal_brain_morphology0.36883310
67MP0001324_abnormal_eye_pigmentation0.36426877
68MP0004811_abnormal_neuron_physiology0.36397324
69MP0006036_abnormal_mitochondrial_physio0.35693579
70MP0002928_abnormal_bile_duct0.35239200
71MP0002735_abnormal_chemical_nociception0.35090902
72MP0001486_abnormal_startle_reflex0.33112593
73MP0002269_muscular_atrophy0.32617997
74MP0005666_abnormal_adipose_tissue0.32351127
75MP0005397_hematopoietic_system_phenotyp0.31435711
76MP0001545_abnormal_hematopoietic_system0.31435711
77MP0008875_abnormal_xenobiotic_pharmacok0.30676734
78MP0003121_genomic_imprinting0.30504359
79MP0005395_other_phenotype0.30074120
80MP0005423_abnormal_somatic_nervous0.30074014
81MP0002837_dystrophic_cardiac_calcinosis0.29371046
82MP0006072_abnormal_retinal_apoptosis0.29153639
83MP0000751_myopathy0.28366955
84MP0009697_abnormal_copulation0.27643335
85MP0001919_abnormal_reproductive_system0.27540042
86MP0002734_abnormal_mechanical_nocicepti0.27074972
87MP0000534_abnormal_ureter_morphology0.27023994
88MP0000462_abnormal_digestive_system0.26220825
89MP0003942_abnormal_urinary_system0.25623912
90MP0003633_abnormal_nervous_system0.25437691
91MP0002067_abnormal_sensory_capabilities0.25360411
92MP0003631_nervous_system_phenotype0.25173950
93MP0002169_no_abnormal_phenotype0.24560597
94MP0002139_abnormal_hepatobiliary_system0.24559588
95MP0003315_abnormal_perineum_morphology0.24518244
96MP0002873_normal_phenotype0.24427364
97MP0001730_embryonic_growth_arrest0.24289124
98MP0008872_abnormal_physiological_respon0.24272364
99MP0002064_seizures0.23608007
100MP0005391_vision/eye_phenotype0.23401743

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39935067
2Abnormal respiratory motile cilium morphology (HP:0005938)8.90509495
3Abnormal respiratory epithelium morphology (HP:0012253)8.90509495
4Rhinitis (HP:0012384)7.66683814
5Abnormal ciliary motility (HP:0012262)7.50947349
6Chronic bronchitis (HP:0004469)7.40676886
7Infertility (HP:0000789)6.93610142
8Nasal polyposis (HP:0100582)6.07389604
9Abnormality of the nasal mucosa (HP:0000433)4.92059970
10Male infertility (HP:0003251)4.67118210
11Bronchiectasis (HP:0002110)4.46028911
12Bronchitis (HP:0012387)4.42369101
13Nephronophthisis (HP:0000090)4.33762995
14Abnormal spermatogenesis (HP:0008669)3.30429754
15Abnormality of the renal medulla (HP:0100957)3.28742201
16Recurrent otitis media (HP:0000403)3.18118721
17Recurrent sinusitis (HP:0011108)3.14397667
18Medial flaring of the eyebrow (HP:0010747)2.93647135
19Impulsivity (HP:0100710)2.83112836
20Tubulointerstitial nephritis (HP:0001970)2.82649692
21Molar tooth sign on MRI (HP:0002419)2.77642317
22Abnormality of midbrain morphology (HP:0002418)2.77642317
23Cholecystitis (HP:0001082)2.45426954
24Abnormal gallbladder physiology (HP:0012438)2.45426954
25Recurrent bronchitis (HP:0002837)2.43497245
26Tubular atrophy (HP:0000092)2.40192349
27Gonadotropin excess (HP:0000837)2.37009606
28Tubulointerstitial abnormality (HP:0001969)2.35684250
29Azoospermia (HP:0000027)2.29724413
30Postaxial foot polydactyly (HP:0001830)2.04495443
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4492884
32Dynein arm defect of respiratory motile cilia (HP:0012255)12.8688105
33Absent/shortened dynein arms (HP:0200106)12.8688105
34Gait imbalance (HP:0002141)1.89792002
35Congenital primary aphakia (HP:0007707)1.87727599
36Tubulointerstitial fibrosis (HP:0005576)1.83282633
37Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82677135
38Stage 5 chronic kidney disease (HP:0003774)1.82448402
39Congenital hepatic fibrosis (HP:0002612)1.80783510
40Dyschromatopsia (HP:0007641)1.78646460
41Spastic tetraparesis (HP:0001285)1.73580204
42Choroideremia (HP:0001139)1.73265021
43Aplasia/Hypoplasia of the lens (HP:0008063)1.70991365
44Abnormality of the lower motor neuron (HP:0002366)1.70707597
45Decreased central vision (HP:0007663)1.69939141
46Renal dysplasia (HP:0000110)1.69817107
47Postaxial hand polydactyly (HP:0001162)1.68605580
48Polydipsia (HP:0001959)1.67085486
49Abnormal drinking behavior (HP:0030082)1.67085486
50Heterotopia (HP:0002282)1.63987445
51Fibular hypoplasia (HP:0003038)1.62524913
52Nephrogenic diabetes insipidus (HP:0009806)1.62025255
53Oculomotor apraxia (HP:0000657)1.61403833
54Pancreatic fibrosis (HP:0100732)1.61132721
55Abnormal biliary tract physiology (HP:0012439)1.59252730
56Bile duct proliferation (HP:0001408)1.59252730
57Abnormality of the renal cortex (HP:0011035)1.59133077
58Short ribs (HP:0000773)1.58719272
59Genital tract atresia (HP:0001827)1.55356326
60Amyotrophic lateral sclerosis (HP:0007354)1.55080277
61Abnormality of permanent molar morphology (HP:0011071)1.52556932
62Abnormality of the dental root (HP:0006486)1.52556932
63Taurodontia (HP:0000679)1.52556932
64Vaginal atresia (HP:0000148)1.52079617
65Poor coordination (HP:0002370)1.50007031
66Facial cleft (HP:0002006)1.47756417
67Cystic liver disease (HP:0006706)1.47706966
68Microglossia (HP:0000171)1.46705359
69Abnormality of renal excretion (HP:0011036)1.46268559
70True hermaphroditism (HP:0010459)1.42707933
71Abnormality of dentin (HP:0010299)1.42347835
72Supernumerary spleens (HP:0009799)1.42211699
73Abnormality of molar morphology (HP:0011070)1.41889120
74Abnormality of molar (HP:0011077)1.41889120
75Absent epiphyses (HP:0010577)1.41555846
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41555846
77Chronic sinusitis (HP:0011109)1.41522772
78Abnormality of the dental pulp (HP:0006479)1.38103743
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.38058717
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.36902522
81Bundle branch block (HP:0011710)1.32547265
82Absent frontal sinuses (HP:0002688)1.30411238
83Retinal dysplasia (HP:0007973)1.30105018
84Bell-shaped thorax (HP:0001591)1.29975184
85Impaired proprioception (HP:0010831)1.29745464
86Short thorax (HP:0010306)1.29193606
87Neurofibrillary tangles (HP:0002185)1.27802087
88Hemorrhage of the eye (HP:0011885)1.25713096
89Abnormality of ocular smooth pursuit (HP:0000617)1.25160831
90Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23748931
91Median cleft lip (HP:0000161)1.21822421
92Hemiparesis (HP:0001269)1.21516283
93Abnormality of saccadic eye movements (HP:0000570)1.17214084
94Short femoral neck (HP:0100864)1.17164725
95Papillary thyroid carcinoma (HP:0002895)1.16509051
96Nephropathy (HP:0000112)1.16092323
97Asymmetric septal hypertrophy (HP:0001670)1.15514542
98Abnormal urine output (HP:0012590)1.15466542
99J-shaped sella turcica (HP:0002680)1.14352152
100Chronic hepatic failure (HP:0100626)1.14030576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.37687056
2PDK48.37687056
3TESK15.36972269
4PDK25.31990366
5PRKD34.98151237
6ICK3.65175699
7PTK2B2.34533231
8PNCK2.23843554
9WNK42.06391565
10STK392.06070527
11STK381.91169025
12NEK21.59783654
13TYRO31.16992759
14PDK11.06321885
15TTK1.02894773
16DYRK1B1.01545624
17STK38L0.98766653
18CHEK20.89472906
19MUSK0.88002144
20MAP2K70.85245087
21STK30.83413589
22PLK40.82272802
23MAP3K40.81495278
24WNK10.75251322
25CCNB10.73405271
26MAP3K60.71437309
27EEF2K0.70206858
28IRAK10.67630636
29NTRK20.65015270
30PINK10.62354191
31MAPKAPK50.62125762
32BRAF0.57473887
33CAMK1G0.55847137
34MAPK150.55827706
35PDPK10.52396849
36DYRK30.51364383
37PASK0.50748416
38MAP2K60.46158679
39CHEK10.45213987
40LMTK20.44701684
41CDC70.44061631
42RIPK40.42945964
43EPHA40.38133502
44ATM0.36470137
45PRKCG0.35140650
46PRKAA10.31835351
47PLK10.31401624
48NTRK30.30946284
49PAK10.29705214
50ERBB40.28854873
51ATR0.27995723
52MAP2K40.27315851
53IRAK20.26962300
54TESK20.26775905
55NEK60.26703553
56CDK120.26593966
57LATS10.26359051
58LATS20.23790428
59CDK30.23138387
60WEE10.22860760
61MARK20.22447470
62CAMK2A0.22129830
63MAP3K50.21009569
64RPS6KB10.20312684
65TAOK30.20016992
66STK100.17907697
67TAOK10.17292775
68CDK150.17012809
69CAMKK10.16205352
70CDK180.14887183
71MTOR0.14845954
72AURKA0.12414706
73CDK11A0.11585729
74MARK10.11276699
75GSK3B0.10282689
76PAK60.10056120
77PLK20.09999550
78MAPK130.09806854
79PRKG10.09171541
80CDK10.08736903
81PRKCQ0.08655240
82PRKCZ0.08196003
83STK110.07785503
84CDK140.07234118
85GRK50.07006961
86CSNK1D0.06926184
87FES0.05511311
88CDK20.05320872
89PAK20.05181140
90OXSR10.05138759
91CSNK2A10.04257482
92PKN10.02445968
93FER0.02305745
94BRSK20.01940243
95CDK90.01691542
96PRKCA0.01619851
97PRKACA0.01422604
98WNK30.01218023
99MAPK80.01029592
100BRSK10.00882472

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.22287145
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.09644853
3Pyruvate metabolism_Homo sapiens_hsa006203.70738140
4Fatty acid biosynthesis_Homo sapiens_hsa000613.62593570
5Basal transcription factors_Homo sapiens_hsa030223.01804220
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95583040
7Linoleic acid metabolism_Homo sapiens_hsa005912.91006240
8Glucagon signaling pathway_Homo sapiens_hsa049222.60574365
9Propanoate metabolism_Homo sapiens_hsa006402.52977394
10Dorso-ventral axis formation_Homo sapiens_hsa043202.15201324
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13457766
12Oocyte meiosis_Homo sapiens_hsa041142.10948952
13Amphetamine addiction_Homo sapiens_hsa050311.98668101
14Fanconi anemia pathway_Homo sapiens_hsa034601.82496439
15Glycerolipid metabolism_Homo sapiens_hsa005611.81332111
16Pentose phosphate pathway_Homo sapiens_hsa000301.76623515
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76360422
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.70616836
19Huntingtons disease_Homo sapiens_hsa050161.66882007
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61284497
21Collecting duct acid secretion_Homo sapiens_hsa049661.57233322
22Ether lipid metabolism_Homo sapiens_hsa005651.56759408
23Selenocompound metabolism_Homo sapiens_hsa004501.51269159
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.48055128
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39091410
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39052481
27Synaptic vesicle cycle_Homo sapiens_hsa047211.36581713
28Cardiac muscle contraction_Homo sapiens_hsa042601.33850489
29PPAR signaling pathway_Homo sapiens_hsa033201.33401453
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.31065839
31Renin secretion_Homo sapiens_hsa049241.29593509
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26214249
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26200021
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26009054
35Long-term potentiation_Homo sapiens_hsa047201.25910355
36Mineral absorption_Homo sapiens_hsa049781.20658679
37Fructose and mannose metabolism_Homo sapiens_hsa000511.19031531
38Purine metabolism_Homo sapiens_hsa002301.10685073
39Carbon metabolism_Homo sapiens_hsa012001.06864070
40RNA transport_Homo sapiens_hsa030131.02850773
41mRNA surveillance pathway_Homo sapiens_hsa030150.99587221
42Insulin secretion_Homo sapiens_hsa049110.98366876
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94705271
44Estrogen signaling pathway_Homo sapiens_hsa049150.86772781
45Fat digestion and absorption_Homo sapiens_hsa049750.85529109
46Nicotine addiction_Homo sapiens_hsa050330.84518097
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83735769
48Fatty acid metabolism_Homo sapiens_hsa012120.82984977
49Taste transduction_Homo sapiens_hsa047420.80801508
50Calcium signaling pathway_Homo sapiens_hsa040200.79053844
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76353580
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72962923
53Glutathione metabolism_Homo sapiens_hsa004800.71857057
54Cocaine addiction_Homo sapiens_hsa050300.70911083
55Arachidonic acid metabolism_Homo sapiens_hsa005900.70091154
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68255693
57Hedgehog signaling pathway_Homo sapiens_hsa043400.67486436
58Circadian entrainment_Homo sapiens_hsa047130.67106092
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65489376
60Fatty acid degradation_Homo sapiens_hsa000710.64888185
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64696505
62Glutamatergic synapse_Homo sapiens_hsa047240.64477289
63Biosynthesis of amino acids_Homo sapiens_hsa012300.61640931
64RNA degradation_Homo sapiens_hsa030180.60965789
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60934458
66Salivary secretion_Homo sapiens_hsa049700.60929704
67Inositol phosphate metabolism_Homo sapiens_hsa005620.56647433
68Thyroid hormone synthesis_Homo sapiens_hsa049180.56231505
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56129746
70cAMP signaling pathway_Homo sapiens_hsa040240.55674031
71Antigen processing and presentation_Homo sapiens_hsa046120.54743220
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52529237
73Dopaminergic synapse_Homo sapiens_hsa047280.52249384
74Chemical carcinogenesis_Homo sapiens_hsa052040.51220476
75Renin-angiotensin system_Homo sapiens_hsa046140.49216013
76Olfactory transduction_Homo sapiens_hsa047400.48234458
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.46571497
78Ovarian steroidogenesis_Homo sapiens_hsa049130.45653306
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.44893493
80Gastric acid secretion_Homo sapiens_hsa049710.43272161
81Cell cycle_Homo sapiens_hsa041100.42794142
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41956786
83Bile secretion_Homo sapiens_hsa049760.41630353
84Pancreatic secretion_Homo sapiens_hsa049720.41054753
85Metabolic pathways_Homo sapiens_hsa011000.37592286
86VEGF signaling pathway_Homo sapiens_hsa043700.37473255
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.37231777
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35959551
89Endocytosis_Homo sapiens_hsa041440.31121265
90Morphine addiction_Homo sapiens_hsa050320.30426756
91Alcoholism_Homo sapiens_hsa050340.30213171
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30161678
93Systemic lupus erythematosus_Homo sapiens_hsa053220.30094239
94AMPK signaling pathway_Homo sapiens_hsa041520.28171564
95Vibrio cholerae infection_Homo sapiens_hsa051100.25916977
96Oxidative phosphorylation_Homo sapiens_hsa001900.23254503
97Protein digestion and absorption_Homo sapiens_hsa049740.22897536
98ABC transporters_Homo sapiens_hsa020100.22885266
99Pyrimidine metabolism_Homo sapiens_hsa002400.20330927
100Oxytocin signaling pathway_Homo sapiens_hsa049210.19499536

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