

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.22313259 |
| 2 | synaptic vesicle maturation (GO:0016188) | 6.01035700 |
| 3 | synaptic vesicle exocytosis (GO:0016079) | 5.75853677 |
| 4 | locomotory exploration behavior (GO:0035641) | 5.65418453 |
| 5 | vocalization behavior (GO:0071625) | 5.58025885 |
| 6 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.56959427 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.54064948 |
| 8 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.53097120 |
| 9 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.22480575 |
| 10 | protein localization to synapse (GO:0035418) | 5.18638102 |
| 11 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.91104769 |
| 12 | regulation of synapse structural plasticity (GO:0051823) | 4.89702407 |
| 13 | glutamate secretion (GO:0014047) | 4.87613577 |
| 14 | exploration behavior (GO:0035640) | 4.87556237 |
| 15 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.75304127 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.58279086 |
| 17 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.54348365 |
| 18 | neuron cell-cell adhesion (GO:0007158) | 4.54235858 |
| 19 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.50688396 |
| 20 | regulation of synaptic vesicle transport (GO:1902803) | 4.38899683 |
| 21 | neurotransmitter secretion (GO:0007269) | 4.34759104 |
| 22 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.26756861 |
| 23 | synaptic transmission, glutamatergic (GO:0035249) | 4.24165944 |
| 24 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 4.23492640 |
| 25 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.20512420 |
| 26 | glutamate receptor signaling pathway (GO:0007215) | 4.19811353 |
| 27 | establishment of mitochondrion localization (GO:0051654) | 4.19670350 |
| 28 | layer formation in cerebral cortex (GO:0021819) | 4.18045519 |
| 29 | mitochondrion transport along microtubule (GO:0047497) | 4.17398970 |
| 30 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 4.17398970 |
| 31 | positive regulation of synapse maturation (GO:0090129) | 4.15157391 |
| 32 | neuron-neuron synaptic transmission (GO:0007270) | 4.08385700 |
| 33 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 4.07714896 |
| 34 | proline biosynthetic process (GO:0006561) | 3.95714567 |
| 35 | dendritic spine morphogenesis (GO:0060997) | 3.90707957 |
| 36 | prepulse inhibition (GO:0060134) | 3.90600213 |
| 37 | positive regulation of membrane potential (GO:0045838) | 3.85882039 |
| 38 | neuronal action potential propagation (GO:0019227) | 3.85358574 |
| 39 | protein retention in ER lumen (GO:0006621) | 3.81687940 |
| 40 | synaptic vesicle endocytosis (GO:0048488) | 3.80942529 |
| 41 | long-term memory (GO:0007616) | 3.80347613 |
| 42 | long-term synaptic potentiation (GO:0060291) | 3.78383305 |
| 43 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.75185568 |
| 44 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.74604172 |
| 45 | regulation of synaptic plasticity (GO:0048167) | 3.70274729 |
| 46 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.69688681 |
| 47 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.66107691 |
| 48 | transmission of nerve impulse (GO:0019226) | 3.65775763 |
| 49 | regulation of early endosome to late endosome transport (GO:2000641) | 3.62918565 |
| 50 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 3.62846063 |
| 51 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.61505826 |
| 52 | cellular potassium ion homeostasis (GO:0030007) | 3.61361077 |
| 53 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.60067244 |
| 54 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.59052771 |
| 55 | behavioral defense response (GO:0002209) | 3.58842338 |
| 56 | behavioral fear response (GO:0001662) | 3.58842338 |
| 57 | protein insertion into membrane (GO:0051205) | 3.54321101 |
| 58 | proline transport (GO:0015824) | 3.53628697 |
| 59 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.53000804 |
| 60 | cell-cell junction maintenance (GO:0045217) | 3.52873957 |
| 61 | neuron recognition (GO:0008038) | 3.52392077 |
| 62 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.50771828 |
| 63 | auditory behavior (GO:0031223) | 3.49129602 |
| 64 | postsynaptic membrane organization (GO:0001941) | 3.48324858 |
| 65 | regulation of postsynaptic membrane potential (GO:0060078) | 3.48250554 |
| 66 | gamma-aminobutyric acid transport (GO:0015812) | 3.47167701 |
| 67 | neurotransmitter transport (GO:0006836) | 3.47147269 |
| 68 | striatum development (GO:0021756) | 3.43626138 |
| 69 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.40357586 |
| 70 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.39072821 |
| 71 | neuromuscular process controlling balance (GO:0050885) | 3.38767404 |
| 72 | negative regulation of cell size (GO:0045792) | 3.38005158 |
| 73 | sodium ion export (GO:0071436) | 3.36972299 |
| 74 | regulation of neurotransmitter secretion (GO:0046928) | 3.35754333 |
| 75 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.34123953 |
| 76 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.31229574 |
| 77 | regulation of vesicle fusion (GO:0031338) | 3.30768744 |
| 78 | activation of protein kinase A activity (GO:0034199) | 3.28675797 |
| 79 | dopamine receptor signaling pathway (GO:0007212) | 3.28047398 |
| 80 | positive regulation of neurotransmitter transport (GO:0051590) | 3.27184852 |
| 81 | fear response (GO:0042596) | 3.26820849 |
| 82 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.26572205 |
| 83 | innervation (GO:0060384) | 3.26193766 |
| 84 | cell migration in hindbrain (GO:0021535) | 3.25281689 |
| 85 | regulation of neurotransmitter transport (GO:0051588) | 3.24072646 |
| 86 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.24021197 |
| 87 | regulation of neurotransmitter levels (GO:0001505) | 3.21992323 |
| 88 | membrane depolarization during action potential (GO:0086010) | 3.21069433 |
| 89 | synaptic transmission, dopaminergic (GO:0001963) | 3.20288273 |
| 90 | learning (GO:0007612) | 3.19656216 |
| 91 | response to auditory stimulus (GO:0010996) | 3.19643480 |
| 92 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.19428921 |
| 93 | activation of MAPKKK activity (GO:0000185) | 3.18979811 |
| 94 | regulation of synapse maturation (GO:0090128) | 3.17797126 |
| 95 | regulation of female receptivity (GO:0045924) | 3.17648355 |
| 96 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.16040000 |
| 97 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.16040000 |
| 98 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.15632069 |
| 99 | cell communication by electrical coupling (GO:0010644) | 3.14751881 |
| 100 | regulation of glutamate secretion (GO:0014048) | 3.14189909 |
| 101 | axonal fasciculation (GO:0007413) | 3.13104788 |
| 102 | response to histamine (GO:0034776) | 3.12462486 |
| 103 | positive regulation of synaptic transmission (GO:0050806) | 3.12439326 |
| 104 | dendrite morphogenesis (GO:0048813) | 3.12373110 |
| 105 | membrane depolarization (GO:0051899) | 3.12047239 |
| 106 | adenosine receptor signaling pathway (GO:0001973) | 3.11541940 |
| 107 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.10706819 |
| 108 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.10384721 |
| 109 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.10076866 |
| 110 | membrane hyperpolarization (GO:0060081) | 3.09780494 |
| 111 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.08361156 |
| 112 | positive regulation of dendritic spine development (GO:0060999) | 3.08057816 |
| 113 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.06762398 |
| 114 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 3.05967044 |
| 115 | behavioral response to cocaine (GO:0048148) | 3.05181194 |
| 116 | dendritic spine organization (GO:0097061) | 3.04750116 |
| 117 | regulation of synaptic transmission (GO:0050804) | 3.03904792 |
| 118 | neuronal ion channel clustering (GO:0045161) | 3.03419727 |
| 119 | synapse assembly (GO:0007416) | 3.02598846 |
| 120 | response to acidic pH (GO:0010447) | 2.97885553 |
| 121 | protein localization to endosome (GO:0036010) | 2.96067430 |
| 122 | respiratory system process (GO:0003016) | 2.87571185 |
| 123 | ribosomal small subunit biogenesis (GO:0042274) | 2.87363435 |
| 124 | tooth mineralization (GO:0034505) | 2.87141080 |
| 125 | protein maturation by protein folding (GO:0022417) | 2.86586035 |
| 126 | cerebellar Purkinje cell layer development (GO:0021680) | 2.85299278 |
| 127 | regulation of ARF protein signal transduction (GO:0032012) | 2.85206705 |
| 128 | negative regulation of microtubule polymerization (GO:0031115) | 2.84245473 |
| 129 | creatine metabolic process (GO:0006600) | 2.82827199 |
| 130 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 2.81045262 |
| 131 | cerebellar granule cell differentiation (GO:0021707) | 2.79736598 |
| 132 | histone arginine methylation (GO:0034969) | 2.74760068 |
| 133 | proline metabolic process (GO:0006560) | 2.73155588 |
| 134 | amino acid import (GO:0043090) | 2.72092182 |
| 135 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling | 2.71443569 |
| 136 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 2.71443569 |
| 137 | positive regulation of protein sumoylation (GO:0033235) | 2.69322684 |
| 138 | apoptotic process involved in morphogenesis (GO:0060561) | 2.65238935 |
| 139 | response to dietary excess (GO:0002021) | 2.62826159 |
| 140 | UV protection (GO:0009650) | 2.62718363 |
| 141 | Golgi transport vesicle coating (GO:0048200) | 2.62397891 |
| 142 | COPI coating of Golgi vesicle (GO:0048205) | 2.62397891 |
| 143 | response to parathyroid hormone (GO:0071107) | 2.62344314 |
| 144 | endoplasmic reticulum calcium ion homeostasis (GO:0032469) | 2.60273642 |
| 145 | positive regulation of protein dephosphorylation (GO:0035307) | 2.58754340 |
| 146 | peptidyl-arginine methylation (GO:0018216) | 2.57795521 |
| 147 | peptidyl-arginine N-methylation (GO:0035246) | 2.57795521 |
| 148 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.57345273 |
| 149 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.55797041 |
| 150 | muscle cell fate commitment (GO:0042693) | 2.53422428 |
| 151 | adherens junction assembly (GO:0034333) | 2.51679789 |
| 152 | activation of Rac GTPase activity (GO:0032863) | 2.49703014 |
| 153 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.48096144 |
| 154 | positive regulation of myotube differentiation (GO:0010831) | 2.46814511 |
| 155 | barbed-end actin filament capping (GO:0051016) | 2.46373868 |
| 156 | cell junction maintenance (GO:0034331) | 2.44524252 |
| 157 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 2.44160342 |
| 158 | mitochondrion localization (GO:0051646) | 2.43964523 |
| 159 | dicarboxylic acid transport (GO:0006835) | 2.43736684 |
| 160 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.42686352 |
| 161 | gluconeogenesis (GO:0006094) | 2.39140423 |
| 162 | protein targeting to plasma membrane (GO:0072661) | 2.37633427 |
| 163 | L-amino acid import (GO:0043092) | 2.34884326 |
| 164 | positive regulation of mitochondrion organization (GO:0010822) | 2.34144967 |
| 165 | regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315) | 2.30886508 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.30767591 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 4.00906443 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.36356643 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.15470889 |
| 5 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 3.04496814 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.04430412 |
| 7 | LXR_22292898_ChIP-Seq_THP-1_Human | 3.03466819 |
| 8 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.02719816 |
| 9 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.02690549 |
| 10 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.98923435 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.74149066 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.71922934 |
| 13 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.71922934 |
| 14 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.71218327 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.65415483 |
| 16 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.64575485 |
| 17 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.60546668 |
| 18 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.58429591 |
| 19 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.54023609 |
| 20 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.52104357 |
| 21 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.51752721 |
| 22 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.49101400 |
| 23 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.47333526 |
| 24 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.43121110 |
| 25 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.42423181 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.41204925 |
| 27 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.40389329 |
| 28 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.35143409 |
| 29 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.34338963 |
| 30 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.26715838 |
| 31 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.24270770 |
| 32 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.20932687 |
| 33 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.20531140 |
| 34 | MYC_22102868_ChIP-Seq_BL_Human | 2.18702232 |
| 35 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.13562382 |
| 36 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.10699261 |
| 37 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.09744590 |
| 38 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.09443976 |
| 39 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 2.07835632 |
| 40 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.96421993 |
| 41 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.95900902 |
| 42 | P68_20966046_ChIP-Seq_HELA_Human | 1.95416108 |
| 43 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.93916779 |
| 44 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.93180632 |
| 45 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.93180585 |
| 46 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.87844446 |
| 47 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.87818306 |
| 48 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.85795928 |
| 49 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.83161439 |
| 50 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.82998766 |
| 51 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.78480293 |
| 52 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.69955142 |
| 53 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.69271885 |
| 54 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.67491214 |
| 55 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.66237568 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.65247420 |
| 57 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.64133532 |
| 58 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.58663643 |
| 59 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.58234844 |
| 60 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.55246926 |
| 61 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.53032381 |
| 62 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.53024275 |
| 63 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.52434057 |
| 64 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.52355038 |
| 65 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.51843160 |
| 66 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.50539392 |
| 67 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.49888352 |
| 68 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.49691742 |
| 69 | * CREB1_26743006_Chip-Seq_LNCaP_Human | 1.47364097 |
| 70 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.46044522 |
| 71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.45663861 |
| 72 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.43646832 |
| 73 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.43208246 |
| 74 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.40866470 |
| 75 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.36890663 |
| 76 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.36464723 |
| 77 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.32438272 |
| 78 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.32097683 |
| 79 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.31532506 |
| 80 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.31075908 |
| 81 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.31072698 |
| 82 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.31050872 |
| 83 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.30786508 |
| 84 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.30092121 |
| 85 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.29668285 |
| 86 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.28886535 |
| 87 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.28460276 |
| 88 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.28113505 |
| 89 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.27642866 |
| 90 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.26947086 |
| 91 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.26947009 |
| 92 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.26772509 |
| 93 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.26495920 |
| 94 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26268387 |
| 95 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.26090079 |
| 96 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.25429724 |
| 97 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.24153724 |
| 98 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.23612548 |
| 99 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.22684028 |
| 100 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.22592675 |
| 101 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.21447081 |
| 102 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.20852836 |
| 103 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.19407071 |
| 104 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.18899391 |
| 105 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.18353423 |
| 106 | MAF_26560356_Chip-Seq_TH2_Human | 1.17446086 |
| 107 | P300_19829295_ChIP-Seq_ESCs_Human | 1.17272035 |
| 108 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.17063624 |
| 109 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.16768457 |
| 110 | AR_19668381_ChIP-Seq_PC3_Human | 1.16192450 |
| 111 | SA1_27219007_Chip-Seq_Bcells_Human | 1.15868877 |
| 112 | AR_25329375_ChIP-Seq_VCAP_Human | 1.15363970 |
| 113 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.15057553 |
| 114 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.14111870 |
| 115 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.13229483 |
| 116 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.12278299 |
| 117 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.11026078 |
| 118 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.10869572 |
| 119 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.10071844 |
| 120 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.09196338 |
| 121 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.08661855 |
| 122 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.08521968 |
| 123 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08163449 |
| 124 | STAT3_23295773_ChIP-Seq_U87_Human | 1.06912223 |
| 125 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.06626204 |
| 126 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.05386892 |
| 127 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.05231792 |
| 128 | KDM2B_26808549_Chip-Seq_K562_Human | 1.04868993 |
| 129 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.04368063 |
| 130 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.04232338 |
| 131 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.02789963 |
| 132 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.02436791 |
| 133 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.02236077 |
| 134 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.01980040 |
| 135 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.01954730 |
| 136 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.01751935 |
| 137 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.01545269 |
| 138 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.01031661 |
| 139 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.00935636 |
| 140 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.00620632 |
| 141 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.00360714 |
| 142 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.99697849 |
| 143 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.98934190 |
| 144 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.98775612 |
| 145 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.98747615 |
| 146 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.98453581 |
| 147 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 0.97729644 |
| 148 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.97503064 |
| 149 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.95997331 |
| 150 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.94389875 |
| 151 | TCF4_23295773_ChIP-Seq_U87_Human | 0.93824868 |
| 152 | JUN_21703547_ChIP-Seq_K562_Human | 0.92859485 |
| 153 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.91351396 |
| 154 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.90155913 |
| 155 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.89259931 |
| 156 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.89210182 |
| 157 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89086798 |
| 158 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.89086798 |
| 159 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.88385864 |
| 160 | FUS_26573619_Chip-Seq_HEK293_Human | 0.87825208 |
| 161 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.86927951 |
| 162 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.86483262 |
| 163 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.86217386 |
| 164 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85096173 |
| 165 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.84911338 |
| 166 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.84657799 |
| 167 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.84627071 |
| 168 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84475277 |
| 169 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.83535118 |
| 170 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.83084160 |
| 171 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.82712641 |
| 172 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.81481364 |
| 173 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.81068342 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.50953518 |
| 2 | MP0003880_abnormal_central_pattern | 4.56850812 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.18168461 |
| 4 | MP0002822_catalepsy | 3.66819017 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.43656997 |
| 6 | MP0009745_abnormal_behavioral_response | 3.36626891 |
| 7 | MP0004270_analgesia | 3.24043776 |
| 8 | MP0009046_muscle_twitch | 3.03549020 |
| 9 | MP0002064_seizures | 3.02300818 |
| 10 | MP0005058_abnormal_lysosome_morphology | 2.90068890 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.88781071 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.83772231 |
| 13 | MP0005423_abnormal_somatic_nervous | 2.57159663 |
| 14 | MP0002249_abnormal_larynx_morphology | 2.46977498 |
| 15 | MP0002272_abnormal_nervous_system | 2.44164579 |
| 16 | MP0001486_abnormal_startle_reflex | 2.43333035 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.39844346 |
| 18 | MP0003705_abnormal_hypodermis_morpholog | 2.31419387 |
| 19 | MP0005623_abnormal_meninges_morphology | 2.29047936 |
| 20 | MP0002736_abnormal_nociception_after | 2.27476173 |
| 21 | MP0005451_abnormal_body_composition | 2.16102377 |
| 22 | MP0001501_abnormal_sleep_pattern | 2.14126013 |
| 23 | MP0001984_abnormal_olfaction | 2.01751258 |
| 24 | MP0001440_abnormal_grooming_behavior | 1.98140086 |
| 25 | MP0001529_abnormal_vocalization | 1.97725746 |
| 26 | MP0000678_abnormal_parathyroid_gland | 1.95353111 |
| 27 | MP0002184_abnormal_innervation | 1.91672301 |
| 28 | MP0002735_abnormal_chemical_nociception | 1.90977144 |
| 29 | MP0001970_abnormal_pain_threshold | 1.87751670 |
| 30 | MP0002733_abnormal_thermal_nociception | 1.86848466 |
| 31 | MP0002067_abnormal_sensory_capabilities | 1.85189952 |
| 32 | MP0002557_abnormal_social/conspecific_i | 1.84927540 |
| 33 | MP0004811_abnormal_neuron_physiology | 1.81714536 |
| 34 | MP0000778_abnormal_nervous_system | 1.77306215 |
| 35 | MP0009780_abnormal_chondrocyte_physiolo | 1.75716721 |
| 36 | MP0004924_abnormal_behavior | 1.75118574 |
| 37 | MP0005386_behavior/neurological_phenoty | 1.75118574 |
| 38 | MP0000604_amyloidosis | 1.69766472 |
| 39 | MP0005646_abnormal_pituitary_gland | 1.69335141 |
| 40 | MP0003787_abnormal_imprinting | 1.68848488 |
| 41 | MP0004858_abnormal_nervous_system | 1.67539949 |
| 42 | MP0002909_abnormal_adrenal_gland | 1.65157170 |
| 43 | MP0004510_myositis | 1.63468552 |
| 44 | MP0008260_abnormal_autophagy | 1.61198462 |
| 45 | MP0003122_maternal_imprinting | 1.61136526 |
| 46 | MP0000681_abnormal_thyroid_gland | 1.59929026 |
| 47 | MP0003172_abnormal_lysosome_physiology | 1.58494943 |
| 48 | MP0000955_abnormal_spinal_cord | 1.57176597 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.57148038 |
| 50 | MP0008569_lethality_at_weaning | 1.56315499 |
| 51 | MP0001502_abnormal_circadian_rhythm | 1.54973137 |
| 52 | MP0009840_abnormal_foam_cell | 1.53102555 |
| 53 | MP0000747_muscle_weakness | 1.50833416 |
| 54 | MP0003329_amyloid_beta_deposits | 1.49049881 |
| 55 | MP0003879_abnormal_hair_cell | 1.48140113 |
| 56 | MP0004185_abnormal_adipocyte_glucose | 1.48124388 |
| 57 | MP0002882_abnormal_neuron_morphology | 1.45779377 |
| 58 | MP0001348_abnormal_lacrimal_gland | 1.42921944 |
| 59 | MP0000759_abnormal_skeletal_muscle | 1.39093247 |
| 60 | MP0002066_abnormal_motor_capabilities/c | 1.38271045 |
| 61 | MP0009278_abnormal_bone_marrow | 1.35341902 |
| 62 | MP0005670_abnormal_white_adipose | 1.31729984 |
| 63 | MP0005645_abnormal_hypothalamus_physiol | 1.31728311 |
| 64 | MP0002089_abnormal_postnatal_growth/wei | 1.30904683 |
| 65 | MP0004142_abnormal_muscle_tone | 1.28507860 |
| 66 | MP0000750_abnormal_muscle_regeneration | 1.27793786 |
| 67 | MP0000003_abnormal_adipose_tissue | 1.27575526 |
| 68 | MP0001905_abnormal_dopamine_level | 1.26839465 |
| 69 | MP0001188_hyperpigmentation | 1.25748581 |
| 70 | MP0005551_abnormal_eye_electrophysiolog | 1.25500022 |
| 71 | MP0002152_abnormal_brain_morphology | 1.22605038 |
| 72 | MP0002653_abnormal_ependyma_morphology | 1.22042535 |
| 73 | MP0004130_abnormal_muscle_cell | 1.21964992 |
| 74 | MP0005666_abnormal_adipose_tissue | 1.19552676 |
| 75 | MP0004885_abnormal_endolymph | 1.19227846 |
| 76 | MP0001346_abnormal_lacrimal_gland | 1.18847354 |
| 77 | MP0000733_abnormal_muscle_development | 1.17793797 |
| 78 | MP0000920_abnormal_myelination | 1.16813282 |
| 79 | MP0005375_adipose_tissue_phenotype | 1.15521575 |
| 80 | MP0004233_abnormal_muscle_weight | 1.10607622 |
| 81 | MP0003633_abnormal_nervous_system | 1.09703810 |
| 82 | MP0005394_taste/olfaction_phenotype | 1.09619633 |
| 83 | MP0005499_abnormal_olfactory_system | 1.09619633 |
| 84 | MP0000631_abnormal_neuroendocrine_gland | 1.06062687 |
| 85 | MP0003690_abnormal_glial_cell | 1.05511598 |
| 86 | MP0008872_abnormal_physiological_respon | 1.04646103 |
| 87 | MP0000751_myopathy | 1.03768775 |
| 88 | MP0010030_abnormal_orbit_morphology | 1.03053878 |
| 89 | MP0001849_ear_inflammation | 0.99691194 |
| 90 | MP0002069_abnormal_eating/drinking_beha | 0.98000248 |
| 91 | MP0000049_abnormal_middle_ear | 0.96588172 |
| 92 | MP0003303_peritoneal_inflammation | 0.96466338 |
| 93 | MP0006072_abnormal_retinal_apoptosis | 0.96347396 |
| 94 | MP0003631_nervous_system_phenotype | 0.96222233 |
| 95 | MP0008961_abnormal_basal_metabolism | 0.94734547 |
| 96 | MP0004145_abnormal_muscle_electrophysio | 0.93990994 |
| 97 | MP0002090_abnormal_vision | 0.93310663 |
| 98 | MP0002229_neurodegeneration | 0.92384663 |
| 99 | MP0003942_abnormal_urinary_system | 0.90322970 |
| 100 | MP0000013_abnormal_adipose_tissue | 0.90237174 |
| 101 | MP0008877_abnormal_DNA_methylation | 0.89279174 |
| 102 | MP0003123_paternal_imprinting | 0.87854874 |
| 103 | MP0003279_aneurysm | 0.87353948 |
| 104 | MP0003283_abnormal_digestive_organ | 0.86401337 |
| 105 | MP0002752_abnormal_somatic_nervous | 0.84903919 |
| 106 | MP0004087_abnormal_muscle_fiber | 0.81184028 |
| 107 | MP0005257_abnormal_intraocular_pressure | 0.81170619 |
| 108 | MP0005076_abnormal_cell_differentiation | 0.80851544 |
| 109 | MP0004085_abnormal_heartbeat | 0.79228550 |
| 110 | MP0005167_abnormal_blood-brain_barrier | 0.78855674 |
| 111 | MP0006292_abnormal_olfactory_placode | 0.78382977 |
| 112 | MP0009379_abnormal_foot_pigmentation | 0.78313550 |
| 113 | MP0003121_genomic_imprinting | 0.77936156 |
| 114 | MP0003075_altered_response_to | 0.76559486 |
| 115 | MP0002877_abnormal_melanocyte_morpholog | 0.76461162 |
| 116 | MP0004742_abnormal_vestibular_system | 0.75818371 |
| 117 | MP0003634_abnormal_glial_cell | 0.75553949 |
| 118 | MP0001177_atelectasis | 0.75008677 |
| 119 | MP0003861_abnormal_nervous_system | 0.74521889 |
| 120 | MP0001963_abnormal_hearing_physiology | 0.73278974 |
| 121 | MP0006036_abnormal_mitochondrial_physio | 0.71995141 |
| 122 | MP0000537_abnormal_urethra_morphology | 0.70731335 |
| 123 | MP0008874_decreased_physiological_sensi | 0.69935471 |
| 124 | MP0003137_abnormal_impulse_conducting | 0.69751313 |
| 125 | MP0002638_abnormal_pupillary_reflex | 0.68219584 |
| 126 | MP0000343_altered_response_to | 0.67956661 |
| 127 | MP0005410_abnormal_fertilization | 0.67928334 |
| 128 | MP0003938_abnormal_ear_development | 0.65546206 |
| 129 | MP0001270_distended_abdomen | 0.65227934 |
| 130 | MP0005409_darkened_coat_color | 0.65002980 |
| 131 | MP0001664_abnormal_digestion | 0.64966445 |
| 132 | MP0003632_abnormal_nervous_system | 0.64416219 |
| 133 | MP0003698_abnormal_male_reproductive | 0.62210202 |
| 134 | MP0010386_abnormal_urinary_bladder | 0.60157047 |
| 135 | MP0005535_abnormal_body_temperature | 0.58925604 |
| 136 | MP0002102_abnormal_ear_morphology | 0.57110797 |
| 137 | MP0000569_abnormal_digit_pigmentation | 0.56882894 |
| 138 | MP0000534_abnormal_ureter_morphology | 0.56024675 |
| 139 | MP0004215_abnormal_myocardial_fiber | 0.55808714 |
| 140 | MP0002234_abnormal_pharynx_morphology | 0.54961609 |
| 141 | MP0010769_abnormal_survival | 0.54487162 |
| 142 | MP0001943_abnormal_respiration | 0.54236132 |
| 143 | MP0002082_postnatal_lethality | 0.53051361 |
| 144 | MP0010770_preweaning_lethality | 0.53051361 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.39315496 |
| 2 | Focal motor seizures (HP:0011153) | 6.66827722 |
| 3 | Focal seizures (HP:0007359) | 5.21422468 |
| 4 | Visual hallucinations (HP:0002367) | 5.10080268 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.68460204 |
| 6 | Febrile seizures (HP:0002373) | 3.98491614 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 3.95315922 |
| 8 | Atonic seizures (HP:0010819) | 3.90459565 |
| 9 | Absence seizures (HP:0002121) | 3.70546660 |
| 10 | Abnormality of the lower motor neuron (HP:0002366) | 3.66726210 |
| 11 | Hyperthyroidism (HP:0000836) | 3.61030738 |
| 12 | Hyperacusis (HP:0010780) | 3.55555255 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 3.43938699 |
| 14 | Ankle clonus (HP:0011448) | 3.35204404 |
| 15 | Truncus arteriosus (HP:0001660) | 3.31635710 |
| 16 | Dialeptic seizures (HP:0011146) | 3.31615059 |
| 17 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.31337130 |
| 18 | Mutism (HP:0002300) | 3.17348793 |
| 19 | Supranuclear gaze palsy (HP:0000605) | 3.10609527 |
| 20 | Depression (HP:0000716) | 3.09168624 |
| 21 | Action tremor (HP:0002345) | 3.07427405 |
| 22 | Broad-based gait (HP:0002136) | 3.07384806 |
| 23 | Achilles tendon contracture (HP:0001771) | 2.96250434 |
| 24 | Dysdiadochokinesis (HP:0002075) | 2.96048813 |
| 25 | Abnormal eating behavior (HP:0100738) | 2.95253009 |
| 26 | Broad distal phalanx of finger (HP:0009836) | 2.94668476 |
| 27 | Anxiety (HP:0000739) | 2.94056740 |
| 28 | Poor eye contact (HP:0000817) | 2.93614209 |
| 29 | Torticollis (HP:0000473) | 2.91150930 |
| 30 | Gaze-evoked nystagmus (HP:0000640) | 2.80862519 |
| 31 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.77191786 |
| 32 | Amblyopia (HP:0000646) | 2.73588126 |
| 33 | Myopathic facies (HP:0002058) | 2.71435226 |
| 34 | Focal dystonia (HP:0004373) | 2.70937204 |
| 35 | Limb dystonia (HP:0002451) | 2.66643579 |
| 36 | Impaired social interactions (HP:0000735) | 2.66622919 |
| 37 | Abnormal social behavior (HP:0012433) | 2.66622919 |
| 38 | Truncal ataxia (HP:0002078) | 2.66240574 |
| 39 | Dysmetria (HP:0001310) | 2.63248151 |
| 40 | Urinary urgency (HP:0000012) | 2.62176054 |
| 41 | Stridor (HP:0010307) | 2.61843402 |
| 42 | Distal upper limb amyotrophy (HP:0007149) | 2.59723632 |
| 43 | Upper limb amyotrophy (HP:0009129) | 2.59723632 |
| 44 | Abnormality of the Achilles tendon (HP:0005109) | 2.59164964 |
| 45 | Turricephaly (HP:0000262) | 2.58579723 |
| 46 | Hemiparesis (HP:0001269) | 2.52885603 |
| 47 | Polyphagia (HP:0002591) | 2.51353181 |
| 48 | Postural instability (HP:0002172) | 2.51107665 |
| 49 | Craniofacial dystonia (HP:0012179) | 2.50427645 |
| 50 | Hyperventilation (HP:0002883) | 2.49995794 |
| 51 | Ragged-red muscle fibers (HP:0003200) | 2.46770653 |
| 52 | Drooling (HP:0002307) | 2.45638970 |
| 53 | Excessive salivation (HP:0003781) | 2.45638970 |
| 54 | Abnormal gallbladder physiology (HP:0012438) | 2.43274488 |
| 55 | Cholecystitis (HP:0001082) | 2.43274488 |
| 56 | Spastic gait (HP:0002064) | 2.42485211 |
| 57 | Long palpebral fissure (HP:0000637) | 2.41442878 |
| 58 | Annular pancreas (HP:0001734) | 2.40781529 |
| 59 | Double outlet right ventricle (HP:0001719) | 2.40304162 |
| 60 | Congenital malformation of the right heart (HP:0011723) | 2.40304162 |
| 61 | Amyotrophic lateral sclerosis (HP:0007354) | 2.40239506 |
| 62 | Gait imbalance (HP:0002141) | 2.39845313 |
| 63 | Epileptiform EEG discharges (HP:0011182) | 2.37380724 |
| 64 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.35831655 |
| 65 | Abnormality of the aortic arch (HP:0012303) | 2.34795926 |
| 66 | Pointed chin (HP:0000307) | 2.33714225 |
| 67 | Impaired smooth pursuit (HP:0007772) | 2.33638456 |
| 68 | Diminished motivation (HP:0000745) | 2.30193821 |
| 69 | Axonal loss (HP:0003447) | 2.30136994 |
| 70 | Genetic anticipation (HP:0003743) | 2.29781062 |
| 71 | Bradykinesia (HP:0002067) | 2.29505100 |
| 72 | EEG with generalized epileptiform discharges (HP:0011198) | 2.28873561 |
| 73 | Bowel incontinence (HP:0002607) | 2.27088268 |
| 74 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.26240005 |
| 75 | Hypertensive crisis (HP:0100735) | 2.24697821 |
| 76 | Hypercortisolism (HP:0001578) | 2.24330516 |
| 77 | Apathy (HP:0000741) | 2.23979134 |
| 78 | Distal lower limb amyotrophy (HP:0008944) | 2.23265991 |
| 79 | Megalencephaly (HP:0001355) | 2.22585273 |
| 80 | Bulbar palsy (HP:0001283) | 2.22364189 |
| 81 | Hand muscle atrophy (HP:0009130) | 2.22080591 |
| 82 | Papilledema (HP:0001085) | 2.21267748 |
| 83 | Diplopia (HP:0000651) | 2.21198435 |
| 84 | Abnormality of binocular vision (HP:0011514) | 2.21198435 |
| 85 | Vertebral compression fractures (HP:0002953) | 2.20590776 |
| 86 | Progressive inability to walk (HP:0002505) | 2.19806056 |
| 87 | Abnormal large intestine physiology (HP:0012700) | 2.19685088 |
| 88 | Hypsarrhythmia (HP:0002521) | 2.16294315 |
| 89 | Lower limb amyotrophy (HP:0007210) | 2.15257622 |
| 90 | Fetal akinesia sequence (HP:0001989) | 2.14926947 |
| 91 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.13156459 |
| 92 | Absent speech (HP:0001344) | 2.12976794 |
| 93 | Peripheral hypomyelination (HP:0007182) | 2.12935731 |
| 94 | Stereotypic behavior (HP:0000733) | 2.12095132 |
| 95 | Ventricular fibrillation (HP:0001663) | 2.11991325 |
| 96 | Incomplete penetrance (HP:0003829) | 2.10908719 |
| 97 | Specific learning disability (HP:0001328) | 2.09451757 |
| 98 | Cerebral inclusion bodies (HP:0100314) | 2.09172231 |
| 99 | Central scotoma (HP:0000603) | 2.08812586 |
| 100 | Increased variability in muscle fiber diameter (HP:0003557) | 2.08074460 |
| 101 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.07199978 |
| 102 | Hypoplastic left heart (HP:0004383) | 2.06955180 |
| 103 | Elfin facies (HP:0004428) | 2.05857870 |
| 104 | Atelectasis (HP:0100750) | 2.04941089 |
| 105 | Delusions (HP:0000746) | 2.03730602 |
| 106 | Upper motor neuron abnormality (HP:0002127) | 2.03184798 |
| 107 | Impaired vibratory sensation (HP:0002495) | 2.02444740 |
| 108 | Scanning speech (HP:0002168) | 2.01574851 |
| 109 | Overriding aorta (HP:0002623) | 2.00820946 |
| 110 | Pheochromocytoma (HP:0002666) | 2.00293408 |
| 111 | Hemiplegia (HP:0002301) | 2.00257215 |
| 112 | Hypoventilation (HP:0002791) | 1.99601324 |
| 113 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.98990663 |
| 114 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.98990663 |
| 115 | Abnormality of glycolipid metabolism (HP:0010969) | 1.98990663 |
| 116 | Unilateral renal agenesis (HP:0000122) | 1.98901634 |
| 117 | Lower limb muscle weakness (HP:0007340) | 1.97933492 |
| 118 | Poor suck (HP:0002033) | 1.97793467 |
| 119 | Congenital primary aphakia (HP:0007707) | 1.97450246 |
| 120 | Status epilepticus (HP:0002133) | 1.97109545 |
| 121 | Deep palmar crease (HP:0006191) | 1.96424336 |
| 122 | Obstructive sleep apnea (HP:0002870) | 1.95913217 |
| 123 | Exercise-induced myalgia (HP:0003738) | 1.95130780 |
| 124 | Increased cerebral lipofuscin (HP:0011813) | 1.92681622 |
| 125 | Athetosis (HP:0002305) | 1.92130603 |
| 126 | Ankyloglossia (HP:0010296) | 1.92004060 |
| 127 | Sleep apnea (HP:0010535) | 1.91700117 |
| 128 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.91364358 |
| 129 | Hypoplasia of the brainstem (HP:0002365) | 1.91364358 |
| 130 | Generalized hypotonia (HP:0001290) | 1.90486928 |
| 131 | Medial flaring of the eyebrow (HP:0010747) | 1.90386956 |
| 132 | Resting tremor (HP:0002322) | 1.90121853 |
| 133 | Neuronal loss in central nervous system (HP:0002529) | 1.89817114 |
| 134 | Neurofibrillary tangles (HP:0002185) | 1.88601089 |
| 135 | Dementia (HP:0000726) | 1.87667940 |
| 136 | Dysostosis multiplex (HP:0000943) | 1.87591397 |
| 137 | Neoplasm of the heart (HP:0100544) | 1.86718213 |
| 138 | Shoulder girdle muscle weakness (HP:0003547) | 1.86680275 |
| 139 | Insomnia (HP:0100785) | 1.85523807 |
| 140 | Dysmetric saccades (HP:0000641) | 1.84895603 |
| 141 | Renal duplication (HP:0000075) | 1.84594660 |
| 142 | Unsteady gait (HP:0002317) | 1.83826273 |
| 143 | Failure to thrive in infancy (HP:0001531) | 1.83507857 |
| 144 | Hyperparathyroidism (HP:0000843) | 1.83390171 |
| 145 | Cholelithiasis (HP:0001081) | 1.82620914 |
| 146 | Tetraplegia (HP:0002445) | 1.80778277 |
| 147 | Ulnar bowing (HP:0003031) | 1.80373378 |
| 148 | Generalized myoclonic seizures (HP:0002123) | 1.80122372 |
| 149 | Nuclear cataract (HP:0100018) | 1.79884691 |
| 150 | Growth hormone excess (HP:0000845) | 1.79597122 |
| 151 | Abnormality of the thoracic spine (HP:0100711) | 1.79394467 |
| 152 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.79025764 |
| 153 | Neuroendocrine neoplasm (HP:0100634) | 1.79019356 |
| 154 | Clonus (HP:0002169) | 1.78669659 |
| 155 | Testicular atrophy (HP:0000029) | 1.78300672 |
| 156 | Inability to walk (HP:0002540) | 1.78232502 |
| 157 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.78021046 |
| 158 | Distal lower limb muscle weakness (HP:0009053) | 1.77764191 |
| 159 | Abnormality of macular pigmentation (HP:0008002) | 1.77352675 |
| 160 | Abnormal ventriculo-arterial connection (HP:0011563) | 1.76588410 |
| 161 | Transposition of the great arteries (HP:0001669) | 1.76588410 |
| 162 | Abnormal connection of the cardiac segments (HP:0011545) | 1.76588410 |
| 163 | Nephrogenic diabetes insipidus (HP:0009806) | 1.75590240 |
| 164 | Patellar dislocation (HP:0002999) | 1.75282697 |
| 165 | Foot dorsiflexor weakness (HP:0009027) | 1.74493823 |
| 166 | Gastrointestinal stroma tumor (HP:0100723) | 1.74282134 |
| 167 | Abnormality of the gallbladder (HP:0005264) | 1.74081562 |
| 168 | Distal sensory impairment (HP:0002936) | 1.73367434 |
| 169 | Rapidly progressive (HP:0003678) | 1.72586284 |
| 170 | Polygenic inheritance (HP:0010982) | 1.72029321 |
| 171 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.71689208 |
| 172 | Prolonged neonatal jaundice (HP:0006579) | 1.69354361 |
| 173 | Abnormality of the tricuspid valve (HP:0001702) | 1.69213577 |
| 174 | Protrusio acetabuli (HP:0003179) | 1.68136294 |
| 175 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.67423406 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.68160425 |
| 2 | MAP3K9 | 4.67293525 |
| 3 | NTRK3 | 4.19226769 |
| 4 | TRIB3 | 4.00468993 |
| 5 | SMG1 | 3.46867165 |
| 6 | MARK1 | 3.12491979 |
| 7 | NME2 | 2.91337057 |
| 8 | ICK | 2.89423318 |
| 9 | KSR2 | 2.74712837 |
| 10 | MAP3K4 | 2.72328729 |
| 11 | MINK1 | 2.70420208 |
| 12 | ARAF | 2.60410686 |
| 13 | PRKD3 | 2.39997226 |
| 14 | PAK6 | 2.38089595 |
| 15 | MAP3K11 | 2.25090150 |
| 16 | KSR1 | 2.24864053 |
| 17 | NTRK2 | 2.21719648 |
| 18 | IRAK3 | 2.20914151 |
| 19 | DAPK2 | 2.17797989 |
| 20 | SIK1 | 2.17703073 |
| 21 | CASK | 2.12038115 |
| 22 | MAP2K7 | 2.08667143 |
| 23 | ERN1 | 2.04040085 |
| 24 | EEF2K | 2.00168233 |
| 25 | MAP3K12 | 1.94201889 |
| 26 | TESK1 | 1.94045205 |
| 27 | DAPK1 | 1.61156604 |
| 28 | PLK2 | 1.53896233 |
| 29 | CAMKK1 | 1.50120630 |
| 30 | MAP3K13 | 1.47910181 |
| 31 | CDK5 | 1.45455060 |
| 32 | TESK2 | 1.44657451 |
| 33 | MAP2K4 | 1.41778562 |
| 34 | RAF1 | 1.38434400 |
| 35 | MAPK13 | 1.35248624 |
| 36 | PRPF4B | 1.35197197 |
| 37 | PIM2 | 1.35163792 |
| 38 | RIPK4 | 1.32396645 |
| 39 | BCKDK | 1.29869048 |
| 40 | LATS2 | 1.23240639 |
| 41 | GRK5 | 1.20555569 |
| 42 | SIK2 | 1.20308213 |
| 43 | TAOK1 | 1.19990289 |
| 44 | PRKCG | 1.19097655 |
| 45 | CAMK1D | 1.18460501 |
| 46 | PHKG1 | 1.17609356 |
| 47 | PHKG2 | 1.17609356 |
| 48 | NTRK1 | 1.16740789 |
| 49 | LIMK1 | 1.15003235 |
| 50 | VRK2 | 1.14823951 |
| 51 | MAP3K2 | 1.12608215 |
| 52 | BRAF | 1.11291635 |
| 53 | RIPK1 | 1.10196984 |
| 54 | CDK19 | 1.10002388 |
| 55 | FES | 1.09658300 |
| 56 | NEK1 | 1.06491775 |
| 57 | CDK18 | 1.05920709 |
| 58 | STK38 | 1.04751929 |
| 59 | PNCK | 1.03723968 |
| 60 | CDK14 | 1.02978665 |
| 61 | TNIK | 1.01590717 |
| 62 | CDK15 | 1.01526948 |
| 63 | TYRO3 | 0.98818066 |
| 64 | IRAK2 | 0.95901984 |
| 65 | MAPK12 | 0.95252995 |
| 66 | PRKD2 | 0.91261956 |
| 67 | CDK11A | 0.90035976 |
| 68 | UHMK1 | 0.89356082 |
| 69 | CAMK2A | 0.88960921 |
| 70 | PTK2B | 0.87963462 |
| 71 | DYRK1A | 0.80877369 |
| 72 | NME1 | 0.80435938 |
| 73 | CAMKK2 | 0.79116692 |
| 74 | SIK3 | 0.77094258 |
| 75 | TTN | 0.75060668 |
| 76 | ABL2 | 0.74690700 |
| 77 | MAP2K3 | 0.74661407 |
| 78 | LMTK2 | 0.73815911 |
| 79 | SGK223 | 0.73733793 |
| 80 | SGK494 | 0.73733793 |
| 81 | DYRK1B | 0.72722405 |
| 82 | PKN2 | 0.71080346 |
| 83 | CDK12 | 0.69452179 |
| 84 | AURKA | 0.69436479 |
| 85 | MARK2 | 0.68460424 |
| 86 | MAPK11 | 0.68420608 |
| 87 | MAP3K1 | 0.67405295 |
| 88 | CAMK1 | 0.66055244 |
| 89 | TBK1 | 0.65524419 |
| 90 | PAK3 | 0.65378850 |
| 91 | TNK2 | 0.65255235 |
| 92 | CAMK2B | 0.64026701 |
| 93 | MTOR | 0.63996030 |
| 94 | STK11 | 0.63039947 |
| 95 | AKT2 | 0.61838674 |
| 96 | KDR | 0.60428325 |
| 97 | PRKCH | 0.58694422 |
| 98 | CAMK1G | 0.58266090 |
| 99 | CSNK1G3 | 0.58261721 |
| 100 | SGK1 | 0.57444976 |
| 101 | SGK2 | 0.57004494 |
| 102 | BMPR2 | 0.56504237 |
| 103 | DDR2 | 0.55178617 |
| 104 | CDK8 | 0.55011911 |
| 105 | CSNK1G2 | 0.53814486 |
| 106 | MAP3K10 | 0.52700782 |
| 107 | CAMK4 | 0.51347089 |
| 108 | RET | 0.50740526 |
| 109 | PDGFRA | 0.50721896 |
| 110 | MAP2K1 | 0.48653484 |
| 111 | HIPK2 | 0.48393898 |
| 112 | ALK | 0.48184936 |
| 113 | RPS6KC1 | 0.47964100 |
| 114 | RPS6KL1 | 0.47964100 |
| 115 | MAPK4 | 0.47550802 |
| 116 | PRKCZ | 0.47285218 |
| 117 | CSNK1A1L | 0.47251460 |
| 118 | RPS6KA2 | 0.45768521 |
| 119 | PDPK1 | 0.45006757 |
| 120 | PDK1 | 0.44876395 |
| 121 | DAPK3 | 0.44467128 |
| 122 | MOS | 0.43113328 |
| 123 | WNK3 | 0.42813784 |
| 124 | MAPK10 | 0.42172657 |
| 125 | RPS6KA3 | 0.42090107 |
| 126 | ILK | 0.41934254 |
| 127 | STK16 | 0.41632014 |
| 128 | CCNB1 | 0.41621928 |
| 129 | BRSK1 | 0.41596849 |
| 130 | MAPKAPK5 | 0.41384420 |
| 131 | MAP4K1 | 0.41193600 |
| 132 | PDK4 | 0.40821445 |
| 133 | PDK3 | 0.40821445 |
| 134 | PAK1 | 0.40438579 |
| 135 | MAP3K8 | 0.40105541 |
| 136 | PINK1 | 0.39544488 |
| 137 | SGK3 | 0.39544195 |
| 138 | PRKCE | 0.39040564 |
| 139 | PKN1 | 0.38851828 |
| 140 | CDC42BPA | 0.38218913 |
| 141 | MAP3K6 | 0.35046782 |
| 142 | BCR | 0.34049810 |
| 143 | CAMK2G | 0.33225662 |
| 144 | CAMK2D | 0.32980580 |
| 145 | DYRK2 | 0.30741026 |
| 146 | FYN | 0.30122679 |
| 147 | OXSR1 | 0.29730840 |
| 148 | FER | 0.29442854 |
| 149 | TAOK2 | 0.28568675 |
| 150 | ERBB3 | 0.28237845 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.92399999 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.66832880 |
| 3 | Sulfur relay system_Homo sapiens_hsa04122 | 3.13011447 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 3.03013029 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.80827826 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.77300279 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.72224768 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.64943244 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.63786534 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.60561413 |
| 11 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.43205735 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.27348016 |
| 13 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.24060370 |
| 14 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.21668773 |
| 15 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.09668595 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.97946440 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.95495467 |
| 18 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.95405981 |
| 19 | Cocaine addiction_Homo sapiens_hsa05030 | 1.92589478 |
| 20 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.87200768 |
| 21 | Other glycan degradation_Homo sapiens_hsa00511 | 1.85706120 |
| 22 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.80284387 |
| 23 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.80218859 |
| 24 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.78947269 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.77091716 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.71781572 |
| 27 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.69983629 |
| 28 | Taste transduction_Homo sapiens_hsa04742 | 1.69482660 |
| 29 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.67045053 |
| 30 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.66829348 |
| 31 | Long-term depression_Homo sapiens_hsa04730 | 1.65637963 |
| 32 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.64085193 |
| 33 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.59525981 |
| 34 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.55057884 |
| 35 | Gap junction_Homo sapiens_hsa04540 | 1.51108597 |
| 36 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.49774962 |
| 37 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.46617660 |
| 38 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.46450182 |
| 39 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.37680060 |
| 40 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.35077841 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.26527662 |
| 42 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.24848332 |
| 43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.24053782 |
| 44 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.24040933 |
| 45 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.22714388 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.19212344 |
| 47 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.18450655 |
| 48 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.17283682 |
| 49 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.16678111 |
| 50 | Bladder cancer_Homo sapiens_hsa05219 | 1.15317325 |
| 51 | Axon guidance_Homo sapiens_hsa04360 | 1.14308520 |
| 52 | Glioma_Homo sapiens_hsa05214 | 1.14190915 |
| 53 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.10681616 |
| 54 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.10565226 |
| 55 | Melanogenesis_Homo sapiens_hsa04916 | 1.08060923 |
| 56 | Carbon metabolism_Homo sapiens_hsa01200 | 1.07858255 |
| 57 | Lysosome_Homo sapiens_hsa04142 | 1.06872117 |
| 58 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.06389222 |
| 59 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.06119326 |
| 60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.04834779 |
| 61 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04806324 |
| 62 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.02269776 |
| 63 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.97804753 |
| 64 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.96950072 |
| 65 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.96321539 |
| 66 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.95896720 |
| 67 | Phototransduction_Homo sapiens_hsa04744 | 0.94397499 |
| 68 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.93946396 |
| 69 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93360864 |
| 70 | Galactose metabolism_Homo sapiens_hsa00052 | 0.90852482 |
| 71 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.90183002 |
| 72 | Alcoholism_Homo sapiens_hsa05034 | 0.85693501 |
| 73 | Ribosome_Homo sapiens_hsa03010 | 0.85085629 |
| 74 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.78252565 |
| 75 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.73920748 |
| 76 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.73753178 |
| 77 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.72529057 |
| 78 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.70754844 |
| 79 | Base excision repair_Homo sapiens_hsa03410 | 0.70102994 |
| 80 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.69084019 |
| 81 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.67116220 |
| 82 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.66814187 |
| 83 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.66256431 |
| 84 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.62985508 |
| 85 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.62637059 |
| 86 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.62533910 |
| 87 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.61256458 |
| 88 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.60918765 |
| 89 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.60609635 |
| 90 | Alzheimers disease_Homo sapiens_hsa05010 | 0.60551334 |
| 91 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.58678948 |
| 92 | Salmonella infection_Homo sapiens_hsa05132 | 0.57542289 |
| 93 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.57534131 |
| 94 | Parkinsons disease_Homo sapiens_hsa05012 | 0.55128287 |
| 95 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.55118288 |
| 96 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.54734898 |
| 97 | Endometrial cancer_Homo sapiens_hsa05213 | 0.54559940 |
| 98 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.53986014 |
| 99 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53412178 |
| 100 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52360441 |
| 101 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.52202022 |
| 102 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.52026796 |
| 103 | Circadian rhythm_Homo sapiens_hsa04710 | 0.51000583 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.50857685 |
| 105 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.50733116 |
| 106 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.50183155 |
| 107 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.50143348 |
| 108 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.50094842 |
| 109 | Prion diseases_Homo sapiens_hsa05020 | 0.49951573 |
| 110 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.48895627 |
| 111 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.48398554 |
| 112 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.47678628 |
| 113 | Endocytosis_Homo sapiens_hsa04144 | 0.46758758 |
| 114 | Colorectal cancer_Homo sapiens_hsa05210 | 0.46584829 |
| 115 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.46110037 |
| 116 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.45521974 |
| 117 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.43929373 |
| 118 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.41545772 |
| 119 | Huntingtons disease_Homo sapiens_hsa05016 | 0.41535100 |
| 120 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.40530572 |
| 121 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.38894827 |
| 122 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.38538942 |
| 123 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.38472426 |
| 124 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.37774203 |
| 125 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.35851168 |
| 126 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.33483576 |
| 127 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.32803550 |
| 128 | Melanoma_Homo sapiens_hsa05218 | 0.31859705 |
| 129 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.31066687 |
| 130 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.30745952 |
| 131 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.27588775 |
| 132 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.26211145 |
| 133 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.20928652 |
| 134 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.20342220 |
| 135 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.20127069 |

