CCDC110

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.95747965
2cilium movement (GO:0003341)9.55608804
3motile cilium assembly (GO:0044458)9.10250328
4spermatid development (GO:0007286)8.97737466
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.85042578
6piRNA metabolic process (GO:0034587)8.71849590
7regulation of cilium movement (GO:0003352)8.64463234
8male meiosis (GO:0007140)8.43313458
9single fertilization (GO:0007338)7.84517503
10sperm capacitation (GO:0048240)7.71995809
11synaptonemal complex organization (GO:0070193)7.41955698
12synaptonemal complex assembly (GO:0007130)7.23540115
13fertilization (GO:0009566)6.47683111
14ventricular system development (GO:0021591)6.34978814
15negative regulation of inclusion body assembly (GO:0090084)5.95171936
16spermatogenesis (GO:0007283)5.74471675
17male gamete generation (GO:0048232)5.72446877
18microtubule depolymerization (GO:0007019)5.48574610
19DNA methylation involved in gamete generation (GO:0043046)5.43762270
20gamete generation (GO:0007276)5.29300055
21male meiosis I (GO:0007141)5.27201094
22cellular process involved in reproduction in multicellular organism (GO:0022412)5.21453572
23germ cell development (GO:0007281)5.12605222
24chromosome organization involved in meiosis (GO:0070192)5.10096238
25cell recognition (GO:0008037)5.09789414
26organic cation transport (GO:0015695)5.09781145
27regulation of microtubule-based movement (GO:0060632)5.06431408
28microtubule severing (GO:0051013)5.00971710
29calcium ion-dependent exocytosis (GO:0017156)4.98412704
30regulation of inclusion body assembly (GO:0090083)4.93917806
31spermatid nucleus differentiation (GO:0007289)4.80154641
32meiotic nuclear division (GO:0007126)4.68467213
33hindbrain development (GO:0030902)4.32919075
34monoubiquitinated protein deubiquitination (GO:0035520)4.30885036
35protein localization to cilium (GO:0061512)4.21265443
36left/right pattern formation (GO:0060972)4.20024078
37multicellular organismal reproductive process (GO:0048609)4.18218074
38meiosis I (GO:0007127)4.17822337
39seminiferous tubule development (GO:0072520)4.09451050
40protein polyglutamylation (GO:0018095)3.99576873
41meiotic cell cycle (GO:0051321)3.86394080
42response to pheromone (GO:0019236)3.86385323
43water-soluble vitamin biosynthetic process (GO:0042364)3.86196222
44endocrine pancreas development (GO:0031018)3.85389241
45intraciliary transport (GO:0042073)3.77744451
46genitalia morphogenesis (GO:0035112)3.71272426
47glycerophospholipid catabolic process (GO:0046475)3.71030629
48regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.66198908
49glycerol ether metabolic process (GO:0006662)3.60346759
50microtubule-based movement (GO:0007018)3.55429566
51regulation of type B pancreatic cell apoptotic process (GO:2000674)3.54153083
52detection of calcium ion (GO:0005513)3.49759088
53protein targeting to Golgi (GO:0000042)3.40360479
54axoneme assembly (GO:0035082)3.38206751
55multicellular organismal development (GO:0007275)3.35982875
56establishment of protein localization to Golgi (GO:0072600)3.35473603
57regulation of hexokinase activity (GO:1903299)3.35084814
58regulation of glucokinase activity (GO:0033131)3.35084814
59chaperone-mediated protein complex assembly (GO:0051131)3.34109116
60ether metabolic process (GO:0018904)3.32262818
61cilium organization (GO:0044782)3.31336005
62negative regulation of organelle assembly (GO:1902116)3.26434040
63chemosensory behavior (GO:0007635)3.23572795
64gene silencing by RNA (GO:0031047)3.23439308
65protein K11-linked deubiquitination (GO:0035871)3.19458750
66cilium assembly (GO:0042384)3.18692322
67synapsis (GO:0007129)3.16062985
68regulation of centriole replication (GO:0046599)3.15451542
69protein localization to Golgi apparatus (GO:0034067)3.14206129
70retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12809343
71cellular ketone body metabolic process (GO:0046950)3.08229672
72respiratory chain complex IV assembly (GO:0008535)3.08150195
73cellular component assembly involved in morphogenesis (GO:0010927)3.07245032
74nucleoside diphosphate phosphorylation (GO:0006165)3.05357945
75alditol metabolic process (GO:0019400)2.98822418
76meiotic cell cycle process (GO:1903046)2.97715040
77centriole replication (GO:0007099)2.97420287
78lactate metabolic process (GO:0006089)2.97330006
79protein refolding (GO:0042026)2.97121554
80primary amino compound metabolic process (GO:1901160)2.96912025
81positive regulation of meiosis (GO:0045836)2.96808831
82inositol phosphate catabolic process (GO:0071545)2.96465314
83single strand break repair (GO:0000012)2.95460913
84carnitine transport (GO:0015879)2.95218896
85amino-acid betaine transport (GO:0015838)2.95218896
86centriole assembly (GO:0098534)2.95155527
87polyol catabolic process (GO:0046174)2.94506068
88COPII vesicle coating (GO:0048208)2.94184697
89microtubule polymerization or depolymerization (GO:0031109)2.93535943
90cilium morphogenesis (GO:0060271)2.92305589
91carnitine transmembrane transport (GO:1902603)2.88785672
92serotonin metabolic process (GO:0042428)2.88345621
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87971555
94signal peptide processing (GO:0006465)2.87615972
95left/right axis specification (GO:0070986)2.87320267
96presynaptic membrane assembly (GO:0097105)2.83700357
97intra-Golgi vesicle-mediated transport (GO:0006891)2.83426648
98chromosome condensation (GO:0030261)2.83040920
99nuclear pore complex assembly (GO:0051292)2.82222932
100lipid particle organization (GO:0034389)2.81066706
101glycolytic process (GO:0006096)2.80443668
102regulation of spindle checkpoint (GO:0090231)2.80020963
103positive regulation of meiotic cell cycle (GO:0051446)2.75977063
104nonmotile primary cilium assembly (GO:0035058)2.74493995
105ketone body metabolic process (GO:1902224)2.70307691
106glycerol metabolic process (GO:0006071)2.69132571
107inositol phosphate dephosphorylation (GO:0046855)2.69120828
108phosphorylated carbohydrate dephosphorylation (GO:0046838)2.69120828
109positive regulation of glycolytic process (GO:0045821)2.68531264
110branched-chain amino acid catabolic process (GO:0009083)2.66816526
111DNA packaging (GO:0006323)2.66494782
112protein localization to synapse (GO:0035418)2.66284943
113nucleus organization (GO:0006997)2.64581341
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64508646
115GTP biosynthetic process (GO:0006183)2.63080426
116negative regulation of hormone biosynthetic process (GO:0032353)2.62870627
117positive regulation of protein autophosphorylation (GO:0031954)2.62323405
118peptidyl-glutamic acid modification (GO:0018200)2.56857238
119glandular epithelial cell differentiation (GO:0002067)2.55320231
120type B pancreatic cell development (GO:0003323)2.54988680
121insulin secretion (GO:0030073)2.54692882
122nitric oxide mediated signal transduction (GO:0007263)2.54555706
123cellular response to ATP (GO:0071318)2.54527414
124sexual reproduction (GO:0019953)2.53545843
125regulation of meiosis I (GO:0060631)2.53289109
126nucleoside diphosphate catabolic process (GO:0009134)2.53239405
127calcium ion import (GO:0070509)2.50358607
128presynaptic membrane organization (GO:0097090)2.50056921
129regulation of feeding behavior (GO:0060259)2.47938758
130righting reflex (GO:0060013)2.47548559
131regulation of protein polyubiquitination (GO:1902914)2.46761497
132prostate gland growth (GO:0060736)2.46321069
133mitotic sister chromatid cohesion (GO:0007064)2.41570748
134gene silencing (GO:0016458)2.36063952
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35343940
136regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.34828032
137positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34016347
138positive regulation of insulin secretion (GO:0032024)2.33610289
139negative regulation of hormone metabolic process (GO:0032351)2.33477680
140neuronal action potential (GO:0019228)2.31129862
141negative regulation of membrane potential (GO:0045837)2.30538957
142L-methionine salvage (GO:0071267)2.29450234
143L-methionine biosynthetic process (GO:0071265)2.29450234
144amino acid salvage (GO:0043102)2.29450234
145protein prenylation (GO:0018342)2.29323259
146prenylation (GO:0097354)2.29323259
147L-alpha-amino acid transmembrane transport (GO:1902475)2.27346394
148preassembly of GPI anchor in ER membrane (GO:0016254)2.27234396
149zinc ion transmembrane transport (GO:0071577)2.25605905
150uterus development (GO:0060065)2.23936084
151histone H4-K12 acetylation (GO:0043983)2.23741905
152reflex (GO:0060004)2.21651998
153regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.21374074
154cytochrome complex assembly (GO:0017004)2.20191807
155phasic smooth muscle contraction (GO:0014821)2.19990982
156pteridine-containing compound biosynthetic process (GO:0042559)2.19884667
157cilium or flagellum-dependent cell motility (GO:0001539)14.8655968
158fusion of sperm to egg plasma membrane (GO:0007342)13.7220331
159sperm motility (GO:0030317)12.6549732
160multicellular organism reproduction (GO:0032504)12.0780571
161cell wall macromolecule catabolic process (GO:0016998)11.9536862
162cell wall macromolecule metabolic process (GO:0044036)11.9536862
163acrosome assembly (GO:0001675)11.8475009
164sperm-egg recognition (GO:0035036)11.4514445
165axonemal dynein complex assembly (GO:0070286)11.1151830
166epithelial cilium movement (GO:0003351)10.5564918
167plasma membrane fusion (GO:0045026)10.4834639
168acrosome reaction (GO:0007340)10.3685544
169cell-cell recognition (GO:0009988)10.2451412
170binding of sperm to zona pellucida (GO:0007339)10.1603179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.13739706
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.11276092
3EZH2_22144423_ChIP-Seq_EOC_Human4.81018699
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.41084225
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.51217412
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99693268
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79001697
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.69599785
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.58057372
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46062194
11GBX2_23144817_ChIP-Seq_PC3_Human2.40056180
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36387668
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.29599130
14VDR_22108803_ChIP-Seq_LS180_Human2.25406204
15P300_19829295_ChIP-Seq_ESCs_Human2.14651551
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10444608
17IGF1R_20145208_ChIP-Seq_DFB_Human2.07522141
18ZNF274_21170338_ChIP-Seq_K562_Hela2.05564647
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.98962893
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95587579
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.93163625
22EWS_26573619_Chip-Seq_HEK293_Human1.92097818
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90523174
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89083448
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88757425
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.87720883
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.84778612
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.81752395
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79275105
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.78779074
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77282942
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.75020595
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73891919
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71087811
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.71044607
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.65344441
37AR_25329375_ChIP-Seq_VCAP_Human1.62550188
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61569834
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.61547531
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61070220
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60991997
42CBP_20019798_ChIP-Seq_JUKART_Human1.60991997
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60915605
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60884101
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60638126
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60404381
47KDM2B_26808549_Chip-Seq_REH_Human1.60358922
48* STAT1_17558387_ChIP-Seq_HELA_Human1.57567908
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56972204
50STAT3_23295773_ChIP-Seq_U87_Human1.55316294
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53900146
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53491550
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52637433
54RNF2_27304074_Chip-Seq_NSC_Mouse1.49836427
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48917278
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.48570857
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.47184223
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.46006519
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42784573
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42603427
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41574872
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.41436696
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.40895382
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37636088
65REST_21632747_ChIP-Seq_MESCs_Mouse1.36147074
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.35928857
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33486179
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.32145302
69P53_22387025_ChIP-Seq_ESCs_Mouse1.32007117
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31167444
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.30940155
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.30648515
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.30140795
74HTT_18923047_ChIP-ChIP_STHdh_Human1.29138068
75P300_18555785_Chip-Seq_ESCs_Mouse1.29028728
76RUNX2_22187159_ChIP-Seq_PCA_Human1.28582948
77TAF15_26573619_Chip-Seq_HEK293_Human1.28398795
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27268339
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26557845
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25550027
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25481493
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.25179747
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25021559
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25021559
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24993873
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24381845
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.23742273
88FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23246098
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22239865
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.22239033
91ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21084192
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21029611
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20821198
94MYC_18940864_ChIP-ChIP_HL60_Human1.20772249
95TP53_22573176_ChIP-Seq_HFKS_Human1.20646436
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20011578
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19155140
98BCAT_22108803_ChIP-Seq_LS180_Human1.18444316
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18351441
100* GATA3_21867929_ChIP-Seq_TH1_Mouse1.16991763
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16367077
102SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15640625
103LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15375772
104GF1_26923725_Chip-Seq_HPCs_Mouse1.15038245
105* TCF4_22108803_ChIP-Seq_LS180_Human1.13405337
106GATA3_21867929_ChIP-Seq_CD8_Mouse1.13377415
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12712133
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12617409
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11837017
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.11613147
111SOX2_19829295_ChIP-Seq_ESCs_Human1.11574518
112NANOG_19829295_ChIP-Seq_ESCs_Human1.11574518
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.11464463
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.10535203
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10456669
116* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09985839
117* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09985839
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09338991
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.08286999
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06609001
121* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06343164
122PU1_27457419_Chip-Seq_LIVER_Mouse1.04890027
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04129413
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04056332
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03052205
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02954887
127AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02252805
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01719457
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.01346790
130ZFX_18555785_Chip-Seq_ESCs_Mouse1.01221836
131JUN_21703547_ChIP-Seq_K562_Human1.01156522
132NCOR_22424771_ChIP-Seq_293T_Human1.01058762
133FUS_26573619_Chip-Seq_HEK293_Human0.99434709
134GF1B_26923725_Chip-Seq_HPCs_Mouse0.99244970
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99135239
136SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98871929
137* CDX2_22108803_ChIP-Seq_LS180_Human0.98189687
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.97852156
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97625982
140P53_21459846_ChIP-Seq_SAOS-2_Human0.96849496
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96578971
142* AR_20517297_ChIP-Seq_VCAP_Human0.96350948
143* TCF4_23295773_ChIP-Seq_U87_Human0.96198407
144* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96140157
145ER_23166858_ChIP-Seq_MCF-7_Human0.94688808
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94357383
147SOX9_26525672_Chip-Seq_HEART_Mouse0.94267925
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92246275
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91972637
150STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90213613
151SMAD4_21799915_ChIP-Seq_A2780_Human0.89916110
152NFYB_21822215_ChIP-Seq_K562_Human0.89589722
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89167217
154TBL1_22424771_ChIP-Seq_293T_Human0.88854330
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88766183
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.88231337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.96356323
2MP0001929_abnormal_gametogenesis5.40634320
3MP0008877_abnormal_DNA_methylation4.95451650
4MP0002653_abnormal_ependyma_morphology3.98656943
5MP0002210_abnormal_sex_determination3.64049578
6MP0002161_abnormal_fertility/fecundity3.26721834
7MP0003195_calcinosis3.20707244
8MP0009780_abnormal_chondrocyte_physiolo3.09686204
9MP0001145_abnormal_male_reproductive3.03201558
10MP0005623_abnormal_meninges_morphology2.94074267
11MP0001986_abnormal_taste_sensitivity2.81238817
12MP0000653_abnormal_sex_gland2.69269108
13MP0003123_paternal_imprinting2.60417554
14MP0003868_abnormal_feces_composition2.54210642
15MP0002909_abnormal_adrenal_gland2.42062622
16MP0000372_irregular_coat_pigmentation2.32795953
17MP0003283_abnormal_digestive_organ2.26482475
18MP0005645_abnormal_hypothalamus_physiol2.09382461
19MP0009046_muscle_twitch2.06005514
20MP0005410_abnormal_fertilization15.0696680
21MP0001666_abnormal_nutrient_absorption1.93520070
22MP0003121_genomic_imprinting1.92634488
23MP0001944_abnormal_pancreas_morphology1.89424186
24MP0005670_abnormal_white_adipose1.88686799
25MP0005220_abnormal_exocrine_pancreas1.87845147
26MP0002282_abnormal_trachea_morphology1.82594086
27MP0003122_maternal_imprinting1.79643247
28MP0002693_abnormal_pancreas_physiology1.76362660
29MP0000013_abnormal_adipose_tissue1.70742525
30MP0004043_abnormal_pH_regulation1.57618200
31MP0002160_abnormal_reproductive_system1.49987884
32MP0002938_white_spotting1.47867242
33MP0005187_abnormal_penis_morphology1.34462874
34MP0008058_abnormal_DNA_repair1.32105001
35MP0003880_abnormal_central_pattern1.29177344
36MP0005647_abnormal_sex_gland1.25013550
37MP0003646_muscle_fatigue1.24424108
38MP0002090_abnormal_vision1.23055498
39MP0008057_abnormal_DNA_replication1.20849056
40MP0010386_abnormal_urinary_bladder1.19560269
41MP0005084_abnormal_gallbladder_morpholo1.18469034
42MP0000631_abnormal_neuroendocrine_gland1.16736058
43MP0001765_abnormal_ion_homeostasis1.14666761
44MP0001984_abnormal_olfaction1.14442204
45MP0002078_abnormal_glucose_homeostasis1.12112836
46MP0003119_abnormal_digestive_system1.10963594
47MP0005332_abnormal_amino_acid1.10781965
48MP0009697_abnormal_copulation1.10451560
49MP0002876_abnormal_thyroid_physiology1.10288185
50MP0004233_abnormal_muscle_weight1.10040348
51MP0002735_abnormal_chemical_nociception1.07937915
52MP0005386_behavior/neurological_phenoty1.07257102
53MP0004924_abnormal_behavior1.07257102
54MP0003718_maternal_effect1.02108934
55MP0002822_catalepsy1.01758655
56MP0006036_abnormal_mitochondrial_physio1.01408239
57MP0005448_abnormal_energy_balance1.00090688
58MP0008995_early_reproductive_senescence0.99080797
59MP0002638_abnormal_pupillary_reflex0.97804649
60MP0002067_abnormal_sensory_capabilities0.96543689
61MP0003953_abnormal_hormone_level0.93674911
62MP0010329_abnormal_lipoprotein_level0.90319106
63MP0001501_abnormal_sleep_pattern0.89705440
64MP0005389_reproductive_system_phenotype0.88002945
65MP0006276_abnormal_autonomic_nervous0.87648231
66MP0000462_abnormal_digestive_system0.86062875
67MP0010094_abnormal_chromosome_stability0.84013270
68MP0005365_abnormal_bile_salt0.81044852
69MP0000516_abnormal_urinary_system0.80823973
70MP0005367_renal/urinary_system_phenotyp0.80823973
71MP0008872_abnormal_physiological_respon0.79474903
72MP0003011_delayed_dark_adaptation0.78067978
73MP0001756_abnormal_urination0.77252078
74MP0005408_hypopigmentation0.76327206
75MP0005452_abnormal_adipose_tissue0.75900893
76MP0000003_abnormal_adipose_tissue0.74921305
77MP0001664_abnormal_digestion0.72025020
78MP0000569_abnormal_digit_pigmentation0.71944450
79MP0004215_abnormal_myocardial_fiber0.69990005
80MP0005646_abnormal_pituitary_gland0.68637212
81MP0005334_abnormal_fat_pad0.68341241
82MP0002102_abnormal_ear_morphology0.67108860
83MP0003950_abnormal_plasma_membrane0.63880278
84MP0002163_abnormal_gland_morphology0.62775092
85MP0002736_abnormal_nociception_after0.60602391
86MP0003786_premature_aging0.59725885
87MP0003699_abnormal_female_reproductive0.59176095
88MP0005551_abnormal_eye_electrophysiolog0.57036449
89MP0001293_anophthalmia0.56749449
90MP0002928_abnormal_bile_duct0.54931354
91MP0005636_abnormal_mineral_homeostasis0.54911814
92MP0003329_amyloid_beta_deposits0.52859999
93MP0004270_analgesia0.51979785
94MP0004036_abnormal_muscle_relaxation0.51613261
95MP0002572_abnormal_emotion/affect_behav0.51388209
96MP0001324_abnormal_eye_pigmentation0.50960666
97MP0001119_abnormal_female_reproductive0.50055360
98MP0000358_abnormal_cell_content/0.48975390
99MP0001968_abnormal_touch/_nociception0.48663457
100MP0003878_abnormal_ear_physiology0.47927874
101MP0005377_hearing/vestibular/ear_phenot0.47927874
102MP0001440_abnormal_grooming_behavior0.46534274
103MP0005253_abnormal_eye_physiology0.46524067
104MP0004145_abnormal_muscle_electrophysio0.46275388
105MP0005379_endocrine/exocrine_gland_phen0.44080636
106MP0009745_abnormal_behavioral_response0.43641773
107MP0008007_abnormal_cellular_replicative0.42571556
108MP0003633_abnormal_nervous_system0.41697991
109MP0003787_abnormal_imprinting0.40904526
110MP0002234_abnormal_pharynx_morphology0.40330196
111MP0002152_abnormal_brain_morphology0.39937499
112MP0005391_vision/eye_phenotype0.39766813
113MP0003635_abnormal_synaptic_transmissio0.39255896
114MP0003861_abnormal_nervous_system0.37072018
115MP0002837_dystrophic_cardiac_calcinosis0.37057922
116MP0002063_abnormal_learning/memory/cond0.36994931
117MP0003115_abnormal_respiratory_system0.36210310
118MP0004811_abnormal_neuron_physiology0.36160467
119MP0004134_abnormal_chest_morphology0.35796741
120MP0004133_heterotaxia0.33723084
121MP0005423_abnormal_somatic_nervous0.33085261
122MP0005666_abnormal_adipose_tissue0.32337389
123MP0002971_abnormal_brown_adipose0.31931946
124MP0003631_nervous_system_phenotype0.31924567
125MP0003879_abnormal_hair_cell0.31152558
126MP0002295_abnormal_pulmonary_circulatio0.30810358
127MP0002064_seizures0.28918862
128MP0009115_abnormal_fat_cell0.28764555
129MP0004858_abnormal_nervous_system0.28694193
130MP0001919_abnormal_reproductive_system0.28676111
131MP0001727_abnormal_embryo_implantation0.27776930
132MP0004019_abnormal_vitamin_homeostasis0.27221561
133MP0002108_abnormal_muscle_morphology0.27132237
134MP0000432_abnormal_head_morphology0.26816061
135MP0006072_abnormal_retinal_apoptosis0.26526972
136MP0001486_abnormal_startle_reflex0.25769322
137MP0004859_abnormal_synaptic_plasticity0.25104026
138MP0002092_abnormal_eye_morphology0.24247568
139MP0002269_muscular_atrophy0.23607660
140MP0002272_abnormal_nervous_system0.23529740
141MP0002229_neurodegeneration0.23007562
142MP0005503_abnormal_tendon_morphology0.22905615
143MP0009250_abnormal_appendicular_skeleto0.22534969
144MP0000427_abnormal_hair_cycle0.22126789
145MP0000778_abnormal_nervous_system0.21949614
146MP0002133_abnormal_respiratory_system0.21184609
147MP0005388_respiratory_system_phenotype0.21184609
148MP0002734_abnormal_mechanical_nocicepti0.21129536
149MP0008569_lethality_at_weaning0.20678849
150MP0004084_abnormal_cardiac_muscle0.20660693
151MP0000751_myopathy0.20631663
152MP0006138_congestive_heart_failure0.20376622
153MP0002557_abnormal_social/conspecific_i0.20213464
154MP0001529_abnormal_vocalization0.20084107

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.81145899
2Abnormal respiratory motile cilium morphology (HP:0005938)8.88559995
3Abnormal respiratory epithelium morphology (HP:0012253)8.88559995
4Abnormal ciliary motility (HP:0012262)8.21549839
5Rhinitis (HP:0012384)8.09475453
6Chronic bronchitis (HP:0004469)7.27929939
7Nasal polyposis (HP:0100582)6.14956849
8Infertility (HP:0000789)6.10035333
9Abnormality of the nasal mucosa (HP:0000433)5.04938163
10Bronchiectasis (HP:0002110)4.70449734
11Bronchitis (HP:0012387)4.59326083
12Nephronophthisis (HP:0000090)4.34625454
13Ketoacidosis (HP:0001993)4.34321066
14Male infertility (HP:0003251)3.88817521
15Hypoglycemic seizures (HP:0002173)3.86662298
16Hyperinsulinemic hypoglycemia (HP:0000825)3.82650792
17Recurrent sinusitis (HP:0011108)3.55997083
18Hypoglycemic coma (HP:0001325)3.54601246
19Enlarged penis (HP:0000040)3.40449763
20Recurrent otitis media (HP:0000403)3.34737878
21Abnormality of the renal medulla (HP:0100957)3.33753889
22Tubulointerstitial nephritis (HP:0001970)3.08575394
23Abnormal spermatogenesis (HP:0008669)3.08403397
24Hyperglycemia (HP:0003074)3.02537988
25Hypothermia (HP:0002045)2.92714492
26Recurrent bronchitis (HP:0002837)2.80256846
27Abnormality of midbrain morphology (HP:0002418)2.78253966
28Molar tooth sign on MRI (HP:0002419)2.78253966
29Medial flaring of the eyebrow (HP:0010747)2.76715332
30Ketosis (HP:0001946)2.75985034
31Pancreatic cysts (HP:0001737)2.75109977
32Abnormality of the lower motor neuron (HP:0002366)2.65876219
33Abnormality of endocrine pancreas physiology (HP:0012093)2.63519241
34Abnormality of the pancreatic islet cells (HP:0006476)2.63519241
35Hyperventilation (HP:0002883)2.61481037
36Abnormal pancreas size (HP:0012094)2.54710527
37Chronic otitis media (HP:0000389)2.53365828
38Large for gestational age (HP:0001520)2.52438039
39Symptomatic seizures (HP:0011145)2.46819753
40Abnormality of the labia minora (HP:0012880)2.46061895
41Tubulointerstitial abnormality (HP:0001969)2.41779553
42Hypomagnesemia (HP:0002917)2.39739779
43Broad-based gait (HP:0002136)2.35448852
44Dialeptic seizures (HP:0011146)2.34517244
45Tubular atrophy (HP:0000092)2.33722443
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30891140
47Fibular hypoplasia (HP:0003038)2.27003141
48Adrenal hypoplasia (HP:0000835)2.26433087
49Protruding tongue (HP:0010808)2.24225194
50EEG with generalized epileptiform discharges (HP:0011198)2.23784901
51Insulin-resistant diabetes mellitus (HP:0000831)2.21280799
52Gaze-evoked nystagmus (HP:0000640)2.20944273
53Gonadotropin excess (HP:0000837)2.20238976
54Impulsivity (HP:0100710)2.19971047
55Postaxial foot polydactyly (HP:0001830)2.19612037
56Epileptiform EEG discharges (HP:0011182)2.18161588
57Azoospermia (HP:0000027)2.16652046
58Hypsarrhythmia (HP:0002521)2.08636973
59Methylmalonic acidemia (HP:0002912)2.08466416
60Amyotrophic lateral sclerosis (HP:0007354)2.08386225
61Congenital hepatic fibrosis (HP:0002612)2.07236892
62Absence seizures (HP:0002121)2.04725964
63Poor suck (HP:0002033)2.00704168
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.1700420
65Absent/shortened dynein arms (HP:0200106)12.5995143
66Dynein arm defect of respiratory motile cilia (HP:0012255)12.5995143
67Supernumerary spleens (HP:0009799)1.99423014
68Microglossia (HP:0000171)1.97551007
69Abnormality of the metopic suture (HP:0005556)1.96477894
70Prominent metopic ridge (HP:0005487)1.95258289
71Occipital encephalocele (HP:0002085)1.95185932
72Pancreatic fibrosis (HP:0100732)1.95070166
73Unilateral renal agenesis (HP:0000122)1.94731354
74Short ribs (HP:0000773)1.92571227
75Abnormality of vitamin B metabolism (HP:0004340)1.91538650
76Dyschromatopsia (HP:0007641)1.91196066
77Absent frontal sinuses (HP:0002688)1.91098137
78Metaphyseal dysplasia (HP:0100255)1.90725827
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89658366
80Renal cortical cysts (HP:0000803)1.87598026
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.86808576
82J-shaped sella turcica (HP:0002680)1.86756169
83Facial cleft (HP:0002006)1.86509602
84Drooling (HP:0002307)1.86385076
85Progressive macrocephaly (HP:0004481)1.86083688
86Sex reversal (HP:0012245)1.85674331
87Abnormal sex determination (HP:0012244)1.85674331
88Stage 5 chronic kidney disease (HP:0003774)1.84697995
89Increased circulating renin level (HP:0000848)1.84246973
90Male pseudohermaphroditism (HP:0000037)1.81888612
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81364528
92Abnormality of alanine metabolism (HP:0010916)1.81364528
93Hyperalaninemia (HP:0003348)1.81364528
94Median cleft lip (HP:0000161)1.81339221
95Steatorrhea (HP:0002570)1.80652753
96Volvulus (HP:0002580)1.79382409
97Lipid accumulation in hepatocytes (HP:0006561)1.79228557
98Fair hair (HP:0002286)1.79175575
99Increased hepatocellular lipid droplets (HP:0006565)1.78204527
100Attenuation of retinal blood vessels (HP:0007843)1.78036380
101Acute necrotizing encephalopathy (HP:0006965)1.77903185
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77100115
103Methylmalonic aciduria (HP:0012120)1.76653825
104Oligodactyly (hands) (HP:0001180)1.76549396
105Exotropia (HP:0000577)1.75957374
106Tubulointerstitial fibrosis (HP:0005576)1.75949949
107Aplasia/hypoplasia of the uterus (HP:0008684)1.75940348
108Chronic sinusitis (HP:0011109)1.74727796
109Hepatic necrosis (HP:0002605)1.73734525
110Gait imbalance (HP:0002141)1.72976738
111Abnormality of the dental root (HP:0006486)1.72394726
112Taurodontia (HP:0000679)1.72394726
113Abnormality of permanent molar morphology (HP:0011071)1.72394726
114Postaxial hand polydactyly (HP:0001162)1.72375942
115Congenital primary aphakia (HP:0007707)1.71165305
116Late onset (HP:0003584)1.70999830
117Furrowed tongue (HP:0000221)1.70738597
118Abnormality of dentin (HP:0010299)1.70202369
119Abnormal protein glycosylation (HP:0012346)1.69967009
120Abnormal glycosylation (HP:0012345)1.69967009
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69967009
122Abnormal protein N-linked glycosylation (HP:0012347)1.69967009
123Oculomotor apraxia (HP:0000657)1.69711092
124Postural tremor (HP:0002174)1.69530262
125Abnormality of the renal cortex (HP:0011035)1.66770454
126Cholecystitis (HP:0001082)1.65834090
127Abnormal gallbladder physiology (HP:0012438)1.65834090
128Abnormality of molar morphology (HP:0011070)1.63139343
129Abnormality of molar (HP:0011077)1.63139343
130Polydipsia (HP:0001959)1.62773471
131Abnormal drinking behavior (HP:0030082)1.62773471
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.60110543
133Renal dysplasia (HP:0000110)1.59029817
134Abnormality of the dental pulp (HP:0006479)1.55757570
135Abnormal biliary tract physiology (HP:0012439)1.55248573
136Bile duct proliferation (HP:0001408)1.55248573
137Cystic liver disease (HP:0006706)1.54267901
138Impaired proprioception (HP:0010831)1.54257638
139Spastic tetraparesis (HP:0001285)1.53666355
140Decreased central vision (HP:0007663)1.50437654
141Short thorax (HP:0010306)1.49778257
142Aplasia/Hypoplasia of the fibula (HP:0006492)1.48829753
143Absent epiphyses (HP:0010577)1.47986218
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47986218
145Chronic hepatic failure (HP:0100626)1.45364956
146Nephrogenic diabetes insipidus (HP:0009806)1.45156089
147Abnormality of ocular smooth pursuit (HP:0000617)1.43672198
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.43112519
149Bell-shaped thorax (HP:0001591)1.43063058
150True hermaphroditism (HP:0010459)1.42822931
151Upper motor neuron abnormality (HP:0002127)1.42731994
152Abnormality of renal excretion (HP:0011036)1.42491249
153Tongue fasciculations (HP:0001308)1.41673863
154Aplasia/Hypoplasia of the lens (HP:0008063)1.41224246
155Heterotopia (HP:0002282)1.40047926
156Deformed sella turcica (HP:0002681)1.39819943
157Genital tract atresia (HP:0001827)1.37003442
158Abnormality of saccadic eye movements (HP:0000570)1.36375840
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32107505
160Vaginal atresia (HP:0000148)1.29386545
161Poor coordination (HP:0002370)1.29234514
162Nephropathy (HP:0000112)1.28444819
163Nephroblastoma (Wilms tumor) (HP:0002667)1.26727703
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.25900045
165Muscle fibrillation (HP:0010546)1.25306612
166Pachygyria (HP:0001302)1.22480310
167Embryonal renal neoplasm (HP:0011794)1.16340639
168Hemiparesis (HP:0001269)1.15566527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.98665697
2PDK38.98665697
3TIE16.92375504
4PDK25.79356662
5FRK4.72227618
6TESK14.07667799
7PRKD33.94840165
8INSRR3.15953466
9PNCK3.03056547
10ICK2.75251478
11PTK2B2.69711174
12GRK12.54632523
13WNK42.44367626
14STK392.39365409
15MST42.07903225
16CDK191.93839780
17ACVR1B1.76592238
18NTRK31.70108381
19FER1.61930174
20PHKG11.56786812
21PHKG21.56786812
22EIF2AK11.51629235
23FGFR21.41931256
24EIF2AK31.38882739
25STK381.36157513
26ZAK1.35914362
27NEK21.28233952
28MAPK151.22505028
29WNK11.08275598
30PAK31.07533786
31TRIM281.03204643
32PRKCE1.02803179
33NEK10.99970531
34BRD40.99547254
35TYRO30.99471165
36CSNK1G10.96418250
37ERBB30.96051146
38PDK10.95915458
39CCNB10.95645180
40STK160.94774346
41BUB10.94550076
42NUAK10.92120378
43IRAK10.91544191
44STK240.88808139
45DYRK1B0.88023308
46DAPK20.87328031
47NLK0.87295309
48TEC0.86988459
49MAP4K20.86540860
50ADRBK20.85944499
51TLK10.85247124
52STK30.82791119
53WEE10.82501366
54MAP2K70.81054126
55CSNK1G30.78521908
56LMTK20.78342051
57PRKAA20.76608406
58TNIK0.76444743
59OBSCN0.76392889
60STK38L0.76319662
61PLK30.75953793
62CSNK1G20.74210192
63TTK0.71748775
64CDC70.68730383
65TGFBR10.63597169
66CHEK20.62159689
67CAMK1G0.61089933
68PRKCI0.60880469
69CDK80.59992500
70TSSK60.58245800
71RIPK40.57543680
72BCKDK0.57500013
73PLK40.55271107
74PASK0.53941327
75MAP3K40.52004897
76UHMK10.51738079
77CHEK10.49259385
78VRK10.48258924
79CSNK1A1L0.48216384
80MAP3K90.48212518
81NME10.47657286
82EPHB10.47655900
83CAMKK20.46756534
84NTRK20.46667911
85IRAK20.46650024
86MAP3K50.45865061
87MAP2K60.43417362
88PBK0.41981420
89CAMK2D0.40213786
90SGK10.40154860
91MUSK0.40094727
92DYRK30.39787407
93ATM0.39199633
94PDPK10.38461408
95NEK60.37227127
96PRKCG0.37102992
97ATR0.35873414
98SGK20.35815707
99CAMK10.35706327
100PRKACA0.35328233
101SGK2230.34226098
102SGK4940.34226098
103MAP3K120.33659921
104TESK20.33415448
105MKNK20.32771002
106PINK10.30601615
107MET0.29621959
108PAK10.28518066
109CSNK1A10.27694615
110MAPKAPK50.26918557
111PLK10.26216707
112BRSK20.25811128
113BMPR1B0.25014747
114PAK20.24239781
115WNK30.23983296
116PRKAA10.17313176
117MTOR0.17141718
118PRKCQ0.16999901
119CAMK2A0.16768891
120MARK10.15929627
121BRSK10.15639024
122CAMKK10.15623696
123RPS6KB10.14450324
124BRAF0.14176363
125STK110.13518122
126PLK20.13363881
127OXSR10.13210143
128PKN10.13195722
129CDK30.11979147
130PRKG10.11579085
131PRKCZ0.11266667
132GRK70.09563730
133PRKDC0.08794038
134CSNK1D0.08515862
135CDK120.08476248
136PRKG20.08447349
137CDK10.07988155
138GSK3B0.07681245
139CDK150.07540530
140EEF2K0.07159764
141MAP2K40.06583397
142MARK20.06267072
143CSNK2A10.06121242
144CDK180.05905806
145CSNK2A20.05463578
146MAPK100.05274322
147CDK50.04832401
148EPHA40.04822349
149PRKACG0.04702433
150ZAP700.04414710
151CASK0.04371465
152CDK11A0.04217977
153CDK20.03921760
154PDGFRB0.03833226
155PRKACB0.03755120
156PRKCA0.03624392
157PRKCB0.03478058
158MINK10.02743548
159STK100.02598892
160MAPK80.02534457
161LATS10.02501058
162MAP3K60.02207553
163AKT30.02161737

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.57864029
2Vitamin B6 metabolism_Homo sapiens_hsa007504.14265132
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.10618399
4Fatty acid biosynthesis_Homo sapiens_hsa000614.07609077
5Pyruvate metabolism_Homo sapiens_hsa006203.57449621
6Protein export_Homo sapiens_hsa030602.93501728
7Propanoate metabolism_Homo sapiens_hsa006402.92207642
8Butanoate metabolism_Homo sapiens_hsa006502.68540436
9Glucagon signaling pathway_Homo sapiens_hsa049222.64524880
10Basal transcription factors_Homo sapiens_hsa030222.58630564
11Pentose phosphate pathway_Homo sapiens_hsa000302.58333302
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51814897
13Linoleic acid metabolism_Homo sapiens_hsa005912.46429307
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43185411
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.40587261
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36823976
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27752724
18Dorso-ventral axis formation_Homo sapiens_hsa043202.25834324
19Fanconi anemia pathway_Homo sapiens_hsa034602.15787627
20Oocyte meiosis_Homo sapiens_hsa041142.09375442
21Huntingtons disease_Homo sapiens_hsa050162.08448996
22Sulfur metabolism_Homo sapiens_hsa009202.01660580
23RNA polymerase_Homo sapiens_hsa030202.00394076
24Oxidative phosphorylation_Homo sapiens_hsa001901.90509131
25Glycerolipid metabolism_Homo sapiens_hsa005611.86957010
26Amphetamine addiction_Homo sapiens_hsa050311.79841015
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79690719
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71981859
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70945630
30Fatty acid elongation_Homo sapiens_hsa000621.68596922
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.61214659
32Selenocompound metabolism_Homo sapiens_hsa004501.47804003
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47644861
34Renin secretion_Homo sapiens_hsa049241.47132193
35Circadian rhythm_Homo sapiens_hsa047101.46624108
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.45417122
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44540001
38PPAR signaling pathway_Homo sapiens_hsa033201.39970042
39Cardiac muscle contraction_Homo sapiens_hsa042601.38191944
40Steroid biosynthesis_Homo sapiens_hsa001001.32235009
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29658259
42Mineral absorption_Homo sapiens_hsa049781.29265020
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.28105867
44Homologous recombination_Homo sapiens_hsa034401.26168217
45Carbon metabolism_Homo sapiens_hsa012001.25647882
46Ether lipid metabolism_Homo sapiens_hsa005651.24854604
47Fructose and mannose metabolism_Homo sapiens_hsa000511.21815646
48Non-homologous end-joining_Homo sapiens_hsa034501.20441157
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18644768
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18479640
51Long-term potentiation_Homo sapiens_hsa047201.15865517
52Parkinsons disease_Homo sapiens_hsa050121.15531600
53Phototransduction_Homo sapiens_hsa047441.14239132
54Renin-angiotensin system_Homo sapiens_hsa046141.11261199
55mRNA surveillance pathway_Homo sapiens_hsa030151.10247497
56Fatty acid metabolism_Homo sapiens_hsa012121.08128726
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.07473374
58Regulation of autophagy_Homo sapiens_hsa041401.07045447
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06600632
60Peroxisome_Homo sapiens_hsa041461.05627148
61RNA transport_Homo sapiens_hsa030131.05167867
62Tryptophan metabolism_Homo sapiens_hsa003801.02294464
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99324864
64Purine metabolism_Homo sapiens_hsa002300.97979189
65Calcium signaling pathway_Homo sapiens_hsa040200.94000070
66Biosynthesis of amino acids_Homo sapiens_hsa012300.93342403
67Insulin secretion_Homo sapiens_hsa049110.91223772
68Estrogen signaling pathway_Homo sapiens_hsa049150.90629586
69Type II diabetes mellitus_Homo sapiens_hsa049300.89702988
70Starch and sucrose metabolism_Homo sapiens_hsa005000.89392035
71Antigen processing and presentation_Homo sapiens_hsa046120.89072298
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89021326
73beta-Alanine metabolism_Homo sapiens_hsa004100.88602351
74Folate biosynthesis_Homo sapiens_hsa007900.87146836
75Taste transduction_Homo sapiens_hsa047420.87123768
76Retinol metabolism_Homo sapiens_hsa008300.86754610
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86629603
78Alzheimers disease_Homo sapiens_hsa050100.86315781
79Nitrogen metabolism_Homo sapiens_hsa009100.85522874
80Arginine and proline metabolism_Homo sapiens_hsa003300.83909070
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83659661
82Collecting duct acid secretion_Homo sapiens_hsa049660.82720597
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80687413
84Synaptic vesicle cycle_Homo sapiens_hsa047210.79085606
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77216830
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75692851
87Fat digestion and absorption_Homo sapiens_hsa049750.74419605
88Caffeine metabolism_Homo sapiens_hsa002320.73057053
89Circadian entrainment_Homo sapiens_hsa047130.72683305
90Olfactory transduction_Homo sapiens_hsa047400.69324487
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68676754
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68602565
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68586307
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68180876
95Salivary secretion_Homo sapiens_hsa049700.67074074
96Thyroid hormone synthesis_Homo sapiens_hsa049180.66291079
97Nicotine addiction_Homo sapiens_hsa050330.64904854
98One carbon pool by folate_Homo sapiens_hsa006700.61966863
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61852342
100Glutamatergic synapse_Homo sapiens_hsa047240.61431771
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.60681408
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60399604
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59689380
104Serotonergic synapse_Homo sapiens_hsa047260.59322309
105Arachidonic acid metabolism_Homo sapiens_hsa005900.58220930
106Gastric acid secretion_Homo sapiens_hsa049710.57745914
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57470490
108GABAergic synapse_Homo sapiens_hsa047270.57041429
109Ovarian steroidogenesis_Homo sapiens_hsa049130.56098826
110Inositol phosphate metabolism_Homo sapiens_hsa005620.54667462
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53987037
112Fatty acid degradation_Homo sapiens_hsa000710.53340353
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51840663
114Pyrimidine metabolism_Homo sapiens_hsa002400.50595961
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48872488
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48826164
117Bile secretion_Homo sapiens_hsa049760.48391312
118cAMP signaling pathway_Homo sapiens_hsa040240.48281167
119ABC transporters_Homo sapiens_hsa020100.48132035
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.47497924
121RNA degradation_Homo sapiens_hsa030180.47296638
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45674523
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44166916
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43687716
125Pancreatic secretion_Homo sapiens_hsa049720.42523675
126Protein digestion and absorption_Homo sapiens_hsa049740.42284646
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41852916
128Tight junction_Homo sapiens_hsa045300.41823056
129Cocaine addiction_Homo sapiens_hsa050300.40065118
130Hedgehog signaling pathway_Homo sapiens_hsa043400.39731392
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.39449596
132Lysine degradation_Homo sapiens_hsa003100.38975554
133Dopaminergic synapse_Homo sapiens_hsa047280.37919141
134Chemical carcinogenesis_Homo sapiens_hsa052040.37066608
135Glutathione metabolism_Homo sapiens_hsa004800.36633151
136VEGF signaling pathway_Homo sapiens_hsa043700.35819636
137Metabolic pathways_Homo sapiens_hsa011000.35784477
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35555867
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.35177945
140Morphine addiction_Homo sapiens_hsa050320.33742529
141Endocytosis_Homo sapiens_hsa041440.33451300
142AMPK signaling pathway_Homo sapiens_hsa041520.32062943
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24888497
144Oxytocin signaling pathway_Homo sapiens_hsa049210.24763932
145Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20393503
146N-Glycan biosynthesis_Homo sapiens_hsa005100.19988417
147Legionellosis_Homo sapiens_hsa051340.19896382
148Wnt signaling pathway_Homo sapiens_hsa043100.17997900
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16901890
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15437020

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