CCDC113

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.76996729
2cell wall macromolecule catabolic process (GO:0016998)9.68552962
3cell wall macromolecule metabolic process (GO:0044036)9.68552962
4sperm-egg recognition (GO:0035036)9.57565497
5plasma membrane fusion (GO:0045026)8.62431763
6binding of sperm to zona pellucida (GO:0007339)8.62333887
7cell-cell recognition (GO:0009988)8.53750042
8acrosome reaction (GO:0007340)8.23538269
9regulation of cilium movement (GO:0003352)8.19626577
10spermatid development (GO:0007286)8.01726527
11reproduction (GO:0000003)7.93697203
12piRNA metabolic process (GO:0034587)7.93383140
13axoneme assembly (GO:0035082)7.89392741
14male meiosis (GO:0007140)7.81427621
15ventricular system development (GO:0021591)7.67531944
16synaptonemal complex organization (GO:0070193)7.06212532
17single fertilization (GO:0007338)6.64997650
18synaptonemal complex assembly (GO:0007130)6.56450769
19sperm capacitation (GO:0048240)6.15743513
20intraciliary transport (GO:0042073)5.84411475
21negative regulation of inclusion body assembly (GO:0090084)5.74257010
22fertilization (GO:0009566)5.60952030
23male meiosis I (GO:0007141)5.47643637
24microtubule severing (GO:0051013)5.43830582
25nucleoside diphosphate phosphorylation (GO:0006165)5.38720130
26vitamin transmembrane transport (GO:0035461)5.37678686
27GTP biosynthetic process (GO:0006183)5.22865338
28primary alcohol catabolic process (GO:0034310)5.20874226
29spermatogenesis (GO:0007283)5.13765109
30male gamete generation (GO:0048232)5.11654343
31DNA methylation involved in gamete generation (GO:0043046)4.96031859
32regulation of microtubule-based movement (GO:0060632)4.94360641
33left/right axis specification (GO:0070986)4.88555525
34cilium organization (GO:0044782)4.84514840
35protein localization to cilium (GO:0061512)4.76906488
36gamete generation (GO:0007276)4.72027509
37regulation of inclusion body assembly (GO:0090083)4.70319542
38UTP biosynthetic process (GO:0006228)4.63033681
39cilium assembly (GO:0042384)4.59200227
40chromosome organization involved in meiosis (GO:0070192)4.53111188
41germ cell development (GO:0007281)4.51288346
42cellular process involved in reproduction in multicellular organism (GO:0022412)4.50742545
43microtubule-based movement (GO:0007018)4.46424707
44protein polyglutamylation (GO:0018095)4.44503430
45spermatid nucleus differentiation (GO:0007289)4.43527419
46left/right pattern formation (GO:0060972)4.40972727
47meiotic nuclear division (GO:0007126)4.38708445
48meiosis I (GO:0007127)4.32262825
49cell recognition (GO:0008037)4.30331390
50cellular component assembly involved in morphogenesis (GO:0010927)4.27265433
51cilium morphogenesis (GO:0060271)4.26346250
52UTP metabolic process (GO:0046051)4.18846202
53calcium ion-dependent exocytosis (GO:0017156)4.16655114
54diol metabolic process (GO:0034311)4.13043419
55one-carbon compound transport (GO:0019755)4.03615044
56organic cation transport (GO:0015695)4.01386378
57ethanol metabolic process (GO:0006067)3.97300914
58microtubule bundle formation (GO:0001578)3.91865615
59diterpenoid biosynthetic process (GO:0016102)3.90955958
60meiotic cell cycle (GO:0051321)3.85907628
61sphingoid metabolic process (GO:0046519)3.85617421
62sphingosine metabolic process (GO:0006670)3.79876086
63microtubule depolymerization (GO:0007019)3.77820885
64multicellular organismal reproductive process (GO:0048609)3.71875480
65guanosine-containing compound biosynthetic process (GO:1901070)3.64563051
66nonmotile primary cilium assembly (GO:0035058)3.62916035
67seminiferous tubule development (GO:0072520)3.61458089
68centriole assembly (GO:0098534)3.60646270
69negative regulation of T cell differentiation in thymus (GO:0033085)3.57296276
70lung epithelium development (GO:0060428)3.47490367
71regulation of interleukin-5 production (GO:0032674)3.46499300
72pyrimidine-containing compound transmembrane transport (GO:0072531)3.43566998
73CTP metabolic process (GO:0046036)3.41592525
74CTP biosynthetic process (GO:0006241)3.41592525
75centriole replication (GO:0007099)3.41281332
76microtubule polymerization or depolymerization (GO:0031109)3.31984370
77response to xenobiotic stimulus (GO:0009410)3.31541385
78retinoic acid metabolic process (GO:0042573)3.30879983
79establishment of monopolar cell polarity (GO:0061162)3.29933423
80establishment or maintenance of monopolar cell polarity (GO:0061339)3.29933423
81establishment of apical/basal cell polarity (GO:0035089)3.29232866
82lateral ventricle development (GO:0021670)3.28999562
83smoothened signaling pathway (GO:0007224)3.20321015
84protein refolding (GO:0042026)3.18333948
85photoreceptor cell maintenance (GO:0045494)3.12714518
86genitalia morphogenesis (GO:0035112)3.11453284
87glomerular epithelial cell development (GO:0072310)3.10212023
88pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.09800831
89cell projection assembly (GO:0030031)3.05404543
90terpenoid biosynthetic process (GO:0016114)3.04413703
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01485099
92chaperone-mediated protein complex assembly (GO:0051131)2.98290913
93monoubiquitinated protein deubiquitination (GO:0035520)2.97790580
94exogenous drug catabolic process (GO:0042738)2.97163055
95retinal cone cell development (GO:0046549)2.95296728
96establishment of tissue polarity (GO:0007164)2.93013123
97establishment of planar polarity (GO:0001736)2.93013123
98lactate metabolic process (GO:0006089)2.92584794
99ethanol oxidation (GO:0006069)2.92204259
100aldehyde catabolic process (GO:0046185)2.90832041
101cornea development in camera-type eye (GO:0061303)2.90375803
102nucleotide phosphorylation (GO:0046939)2.90326083
103negative regulation of organelle assembly (GO:1902116)2.87701423
104pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.86237275
105cytoplasmic microtubule organization (GO:0031122)2.85452899
106lateral sprouting from an epithelium (GO:0060601)2.83872811
107multicellular organismal development (GO:0007275)2.83003272
108regulation of collateral sprouting (GO:0048670)2.80833474
109determination of left/right symmetry (GO:0007368)2.80210563
110gene silencing by RNA (GO:0031047)2.78310658
111synapsis (GO:0007129)2.76569899
112regulation of centriole replication (GO:0046599)2.71889251
113determination of bilateral symmetry (GO:0009855)2.69400887
114meiotic cell cycle process (GO:1903046)2.65045522
115retinal rod cell development (GO:0046548)2.64157766
116specification of symmetry (GO:0009799)2.63096468
117glutathione derivative biosynthetic process (GO:1901687)2.63094902
118glutathione derivative metabolic process (GO:1901685)2.63094902
119negative regulation of immunoglobulin mediated immune response (GO:0002890)2.61496424
120negative regulation of B cell mediated immunity (GO:0002713)2.61496424
121protein K11-linked deubiquitination (GO:0035871)2.59733882
122peptidyl-glutamic acid modification (GO:0018200)2.59723059
123regulation of protein polyubiquitination (GO:1902914)2.58616505
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.58603670
125nucleoside diphosphate metabolic process (GO:0009132)2.58100204
126glycerol ether metabolic process (GO:0006662)2.57126687
127organelle assembly (GO:0070925)2.56492375
128neurotransmitter biosynthetic process (GO:0042136)2.55654818
129microtubule-based process (GO:0007017)2.54599020
130neurotransmitter metabolic process (GO:0042133)2.54404819
131lipopolysaccharide biosynthetic process (GO:0009103)2.54336867
132polyol catabolic process (GO:0046174)2.54041597
133retinol metabolic process (GO:0042572)2.53133594
134regulation of meiosis I (GO:0060631)2.52538065
135behavioral response to nicotine (GO:0035095)2.48039544
136organelle disassembly (GO:1903008)2.44943199
137carnitine metabolic process (GO:0009437)2.43618870
138drug catabolic process (GO:0042737)2.41103031
139primary alcohol metabolic process (GO:0034308)2.39974736
140regulation of protein glycosylation (GO:0060049)2.38959852
141positive regulation of smoothened signaling pathway (GO:0045880)2.37398678
142protein-chromophore linkage (GO:0018298)2.34492856
143O-glycan processing (GO:0016266)2.30058427
144amino-acid betaine metabolic process (GO:0006577)2.28847590
145tolerance induction (GO:0002507)2.28354391
146CDP-diacylglycerol biosynthetic process (GO:0016024)2.28325229
147fucose catabolic process (GO:0019317)2.28301530
148L-fucose metabolic process (GO:0042354)2.28301530
149L-fucose catabolic process (GO:0042355)2.28301530
150appendage development (GO:0048736)2.28219383
151limb development (GO:0060173)2.28219383
152sensory perception of smell (GO:0007608)2.27945338
153negative regulation of JUN kinase activity (GO:0043508)2.27745988
154excretion (GO:0007588)2.25599384
155cilium or flagellum-dependent cell motility (GO:0001539)16.2049806
156axonemal dynein complex assembly (GO:0070286)14.8069595
157cilium movement (GO:0003341)13.2338866
158epithelial cilium movement (GO:0003351)12.1411684
159fusion of sperm to egg plasma membrane (GO:0007342)11.2734221
160acrosome assembly (GO:0001675)10.7426647
161sperm motility (GO:0030317)10.5903487
162motile cilium assembly (GO:0044458)10.4813581
163epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.4169773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.73077681
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.13161673
3EZH2_22144423_ChIP-Seq_EOC_Human4.39933544
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.82119630
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57555857
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53303522
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.49646881
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.38890147
9IGF1R_20145208_ChIP-Seq_DFB_Human2.37157708
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31030693
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.16820641
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08937564
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.06908297
14AR_21572438_ChIP-Seq_LNCaP_Human2.01429310
15DROSHA_22980978_ChIP-Seq_HELA_Human1.97339976
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.94003206
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93917345
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92451675
19VDR_22108803_ChIP-Seq_LS180_Human1.90899841
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88839687
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88506615
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.87804813
23P300_19829295_ChIP-Seq_ESCs_Human1.79405287
24RNF2_27304074_Chip-Seq_NSC_Mouse1.79170214
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.78931253
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78695928
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77335692
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77237791
29NR3C1_21868756_ChIP-Seq_MCF10A_Human1.76892677
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74368373
31ZNF274_21170338_ChIP-Seq_K562_Hela1.72777383
32FUS_26573619_Chip-Seq_HEK293_Human1.72353875
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.71673440
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71659874
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70543348
36TAL1_26923725_Chip-Seq_HPCs_Mouse1.59069288
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58703510
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57555635
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55818407
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53648912
41CBP_20019798_ChIP-Seq_JUKART_Human1.53648912
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.53312034
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53022850
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52268513
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.47370805
46EWS_26573619_Chip-Seq_HEK293_Human1.45593408
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45134366
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.44718792
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42499916
50FLI1_21867929_ChIP-Seq_TH2_Mouse1.42159214
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41994408
52REST_21632747_ChIP-Seq_MESCs_Mouse1.41208405
53P53_22387025_ChIP-Seq_ESCs_Mouse1.40016541
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39818613
55KDM2B_26808549_Chip-Seq_REH_Human1.39745733
56TCF4_22108803_ChIP-Seq_LS180_Human1.38598570
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37899759
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37298891
59AR_25329375_ChIP-Seq_VCAP_Human1.37273824
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36765274
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36765274
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.36146309
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35409649
64STAT1_17558387_ChIP-Seq_HELA_Human1.34337200
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.33952844
66P300_18555785_Chip-Seq_ESCs_Mouse1.33896468
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32422264
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32348031
69* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32231558
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31992267
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.31554731
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31291925
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31132678
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.30943541
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.30836208
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.30022601
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29265180
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28995965
79SMAD4_21799915_ChIP-Seq_A2780_Human1.27917137
80TP53_18474530_ChIP-ChIP_U2OS_Human1.26106956
81* SOX2_19829295_ChIP-Seq_ESCs_Human1.25986468
82* NANOG_19829295_ChIP-Seq_ESCs_Human1.25986468
83KLF4_18555785_Chip-Seq_ESCs_Mouse1.25905762
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25701287
85AHR_22903824_ChIP-Seq_MCF-7_Human1.25349982
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.24628221
87ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23062794
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.22454011
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22081599
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20999075
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20658814
92RUNX2_22187159_ChIP-Seq_PCA_Human1.20395672
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.20012874
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16570182
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15846148
96SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15510015
97NCOR_22424771_ChIP-Seq_293T_Human1.15486074
98PHF8_20622853_ChIP-Seq_HELA_Human1.15132896
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15039847
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14244086
101* EZH2_27294783_Chip-Seq_ESCs_Mouse1.14193771
102ETV1_20927104_ChIP-Seq_GIST48_Human1.13139778
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.13078189
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12785757
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11922123
106PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11742627
107GF1_26923725_Chip-Seq_HPCs_Mouse1.11706610
108TCF4_23295773_ChIP-Seq_U87_Human1.11662910
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.11344803
110HOXB7_26014856_ChIP-Seq_BT474_Human1.10986184
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10626803
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10206493
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.10168572
114LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.08849316
115TAF15_26573619_Chip-Seq_HEK293_Human1.08559900
116ER_23166858_ChIP-Seq_MCF-7_Human1.08419881
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.08207156
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08174077
119GATA3_21867929_ChIP-Seq_CD8_Mouse1.07742229
120PU1_27457419_Chip-Seq_LIVER_Mouse1.06857846
121TP63_23658742_ChIP-Seq_EP156T_Human1.06592569
122AR_20517297_ChIP-Seq_VCAP_Human1.06413537
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06315810
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.06097098
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06010521
126BCAT_22108803_ChIP-Seq_LS180_Human1.04671600
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.03879587
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03879587
129TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02943364
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02837610
131STAT1_20625510_ChIP-Seq_HELA_Human1.02266276
132GF1B_26923725_Chip-Seq_HPCs_Mouse1.02170163
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02128545
134CDX2_22108803_ChIP-Seq_LS180_Human1.01900334
135NMYC_18555785_Chip-Seq_ESCs_Mouse1.01526579
136SMAD3_21741376_ChIP-Seq_ESCs_Human1.01495006
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00319779
138NFYA_21822215_ChIP-Seq_K562_Human1.00233117
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99898457
140GATA3_21867929_ChIP-Seq_TH1_Mouse0.99743354
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99231898
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.99012796
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98959441
144SOX9_26525672_Chip-Seq_HEART_Mouse0.98620029
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98330189
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.98069794
147TBL1_22424771_ChIP-Seq_293T_Human0.97155196
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96521145
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96443623
150CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96433104
151GBX2_23144817_ChIP-Seq_PC3_Human0.96057789
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96004575
153RBPJ_21746931_ChIP-Seq_IB4_Human0.95931291
154STAT3_23295773_ChIP-Seq_U87_Human0.95896527
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.95698333
156SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95562122
157NFYB_21822215_ChIP-Seq_K562_Human0.94994636
158SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92716216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.48256574
2MP0001929_abnormal_gametogenesis4.99341405
3MP0002653_abnormal_ependyma_morphology4.80786190
4MP0008877_abnormal_DNA_methylation4.50487895
5MP0002210_abnormal_sex_determination3.41769636
6MP0005623_abnormal_meninges_morphology3.25636354
7MP0003136_yellow_coat_color3.06780833
8MP0002161_abnormal_fertility/fecundity2.89161426
9MP0001145_abnormal_male_reproductive2.82590651
10MP0004043_abnormal_pH_regulation2.75867203
11MP0002160_abnormal_reproductive_system2.69740702
12MP0003890_abnormal_embryonic-extraembry2.68881314
13MP0000653_abnormal_sex_gland2.50959118
14MP0005171_absent_coat_pigmentation2.42714628
15MP0008789_abnormal_olfactory_epithelium2.41512268
16MP0009046_muscle_twitch2.30177698
17MP0002277_abnormal_respiratory_mucosa2.09321716
18MP0001984_abnormal_olfaction2.09168514
19MP0009780_abnormal_chondrocyte_physiolo2.06478115
20MP0005410_abnormal_fertilization12.8280338
21MP0002282_abnormal_trachea_morphology1.99512197
22MP0008057_abnormal_DNA_replication1.95663108
23MP0005499_abnormal_olfactory_system1.85576155
24MP0005394_taste/olfaction_phenotype1.85576155
25MP0000566_synostosis1.82802550
26MP0004133_heterotaxia1.73364321
27MP0003878_abnormal_ear_physiology1.69460457
28MP0005377_hearing/vestibular/ear_phenot1.69460457
29MP0002735_abnormal_chemical_nociception1.64293203
30MP0002638_abnormal_pupillary_reflex1.58600219
31MP0002168_other_aberrant_phenotype1.55427466
32MP0005670_abnormal_white_adipose1.53845164
33MP0000383_abnormal_hair_follicle1.50217612
34MP0005389_reproductive_system_phenotype1.49525419
35MP0002938_white_spotting1.43856126
36MP0001485_abnormal_pinna_reflex1.40717518
37MP0005551_abnormal_eye_electrophysiolog1.40271206
38MP0005647_abnormal_sex_gland1.36305361
39MP0004147_increased_porphyrin_level1.34105818
40MP0003195_calcinosis1.33060029
41MP0003950_abnormal_plasma_membrane1.30278665
42MP0003879_abnormal_hair_cell1.28751699
43MP0002928_abnormal_bile_duct1.26445322
44MP0003045_fibrosis1.22683820
45MP0005395_other_phenotype1.15803705
46MP0010678_abnormal_skin_adnexa1.14113775
47MP0001765_abnormal_ion_homeostasis1.13055005
48MP0005085_abnormal_gallbladder_physiolo1.12239807
49MP0008995_early_reproductive_senescence1.12083379
50MP0008058_abnormal_DNA_repair1.11660299
51MP0003937_abnormal_limbs/digits/tail_de1.11318678
52MP0003011_delayed_dark_adaptation1.10975002
53MP0001970_abnormal_pain_threshold1.08926926
54MP0008872_abnormal_physiological_respon1.08625331
55MP0000026_abnormal_inner_ear1.06776245
56MP0002233_abnormal_nose_morphology1.02222169
57MP0005646_abnormal_pituitary_gland1.00223578
58MP0003880_abnormal_central_pattern0.97864101
59MP0005253_abnormal_eye_physiology0.97041996
60MP0002234_abnormal_pharynx_morphology0.96238911
61MP0001529_abnormal_vocalization0.95571901
62MP0000569_abnormal_digit_pigmentation0.92651468
63MP0004885_abnormal_endolymph0.92109457
64MP0003137_abnormal_impulse_conducting0.90296924
65MP0008004_abnormal_stomach_pH0.89149671
66MP0006072_abnormal_retinal_apoptosis0.87348723
67MP0005365_abnormal_bile_salt0.83787455
68MP0004381_abnormal_hair_follicle0.82444937
69MP0001968_abnormal_touch/_nociception0.81105173
70MP0001440_abnormal_grooming_behavior0.80961919
71MP0000955_abnormal_spinal_cord0.80896593
72MP0003646_muscle_fatigue0.79698696
73MP0001963_abnormal_hearing_physiology0.77212880
74MP0003718_maternal_effect0.73073612
75MP0009745_abnormal_behavioral_response0.72827046
76MP0001502_abnormal_circadian_rhythm0.72518331
77MP0004215_abnormal_myocardial_fiber0.72065591
78MP0002572_abnormal_emotion/affect_behav0.71893367
79MP0002736_abnormal_nociception_after0.71446016
80MP0010030_abnormal_orbit_morphology0.70831977
81MP0003119_abnormal_digestive_system0.70707261
82MP0001324_abnormal_eye_pigmentation0.70221106
83MP0005248_abnormal_Harderian_gland0.68817528
84MP0004142_abnormal_muscle_tone0.66268649
85MP0002822_catalepsy0.65784043
86MP0005083_abnormal_biliary_tract0.65007829
87MP0003635_abnormal_synaptic_transmissio0.64747490
88MP0003634_abnormal_glial_cell0.64091395
89MP0004233_abnormal_muscle_weight0.63489061
90MP0005391_vision/eye_phenotype0.62359552
91MP0000427_abnormal_hair_cycle0.61555581
92MP0002837_dystrophic_cardiac_calcinosis0.61536868
93MP0002249_abnormal_larynx_morphology0.59383407
94MP0002133_abnormal_respiratory_system0.58098908
95MP0005388_respiratory_system_phenotype0.58098908
96MP0002064_seizures0.58058743
97MP0000778_abnormal_nervous_system0.56773035
98MP0004270_analgesia0.55151036
99MP0002152_abnormal_brain_morphology0.55050432
100MP0002063_abnormal_learning/memory/cond0.53372433
101MP0004859_abnormal_synaptic_plasticity0.52597026
102MP0002557_abnormal_social/conspecific_i0.52175184
103MP0006276_abnormal_autonomic_nervous0.51953397
104MP0002734_abnormal_mechanical_nocicepti0.51947984
105MP0002102_abnormal_ear_morphology0.50103012
106MP0003633_abnormal_nervous_system0.48883322
107MP0005195_abnormal_posterior_eye0.48379603
108MP0003861_abnormal_nervous_system0.48318523
109MP0002909_abnormal_adrenal_gland0.48231154
110MP0002272_abnormal_nervous_system0.47710602
111MP0000358_abnormal_cell_content/0.46366455
112MP0001177_atelectasis0.43670740
113MP0002229_neurodegeneration0.43653590
114MP0001486_abnormal_startle_reflex0.43298591
115MP0000631_abnormal_neuroendocrine_gland0.43040266
116MP0003786_premature_aging0.42624760
117MP0001919_abnormal_reproductive_system0.42486323
118MP0005636_abnormal_mineral_homeostasis0.41826190
119MP0002067_abnormal_sensory_capabilities0.41379575
120MP0005379_endocrine/exocrine_gland_phen0.40287982
121MP0004742_abnormal_vestibular_system0.39783601
122MP0003699_abnormal_female_reproductive0.38941084
123MP0002752_abnormal_somatic_nervous0.38764178
124MP0002882_abnormal_neuron_morphology0.38085626
125MP0000534_abnormal_ureter_morphology0.38062103
126MP0005423_abnormal_somatic_nervous0.37729048
127MP0004036_abnormal_muscle_relaxation0.37268974
128MP0000013_abnormal_adipose_tissue0.36934440
129MP0002876_abnormal_thyroid_physiology0.36855835
130MP0001293_anophthalmia0.36540412
131MP0001545_abnormal_hematopoietic_system0.36312995
132MP0005397_hematopoietic_system_phenotyp0.36312995
133MP0001119_abnormal_female_reproductive0.34940045
134MP0002132_abnormal_respiratory_system0.33771238
135MP0003942_abnormal_urinary_system0.33301389
136MP0008875_abnormal_xenobiotic_pharmacok0.33143186
137MP0009250_abnormal_appendicular_skeleto0.32833569
138MP0004019_abnormal_vitamin_homeostasis0.31973836
139MP0003943_abnormal_hepatobiliary_system0.31471587
140MP0004134_abnormal_chest_morphology0.30924590
141MP0003631_nervous_system_phenotype0.30566253
142MP0002116_abnormal_craniofacial_bone0.30290432
143MP0004811_abnormal_neuron_physiology0.29830140
144MP0000432_abnormal_head_morphology0.29691469
145MP0003329_amyloid_beta_deposits0.28993006

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.64524629
2Abnormal respiratory motile cilium morphology (HP:0005938)9.39875302
3Abnormal respiratory epithelium morphology (HP:0012253)9.39875302
4Chronic bronchitis (HP:0004469)7.64585814
5Nasal polyposis (HP:0100582)5.92006909
6Bronchiectasis (HP:0002110)5.59444743
7Infertility (HP:0000789)5.40899232
8Abnormality of the nasal mucosa (HP:0000433)4.87404106
9Bronchitis (HP:0012387)4.20545085
10Nephronophthisis (HP:0000090)3.86701180
11Recurrent sinusitis (HP:0011108)3.66699777
12Pancreatic fibrosis (HP:0100732)3.37300533
13Male infertility (HP:0003251)3.27736579
14Medial flaring of the eyebrow (HP:0010747)3.26919759
15Abnormality of midbrain morphology (HP:0002418)3.24758233
16Molar tooth sign on MRI (HP:0002419)3.24758233
17Recurrent otitis media (HP:0000403)3.04988728
18True hermaphroditism (HP:0010459)2.96551210
19Abnormality of the renal medulla (HP:0100957)2.95277225
20Chronic sinusitis (HP:0011109)2.79325062
21Tubulointerstitial nephritis (HP:0001970)2.76321088
22Supernumerary spleens (HP:0009799)2.69586592
23Median cleft lip (HP:0000161)2.63071066
24Gait imbalance (HP:0002141)2.51750677
25Congenital primary aphakia (HP:0007707)2.51496424
26Occipital encephalocele (HP:0002085)2.49944474
27Hyperactive renin-angiotensin system (HP:0000841)2.47002422
28Congenital hepatic fibrosis (HP:0002612)2.46731821
29Postaxial foot polydactyly (HP:0001830)2.43293672
30Chronic otitis media (HP:0000389)2.30874480
31Fibular hypoplasia (HP:0003038)2.30469416
32Cystic liver disease (HP:0006706)2.25284601
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.19750554
34Decreased circulating renin level (HP:0003351)2.18485634
35Nephrogenic diabetes insipidus (HP:0009806)2.18415904
36Pancreatic cysts (HP:0001737)2.14852692
37Facial cleft (HP:0002006)2.10478588
38Tubulointerstitial abnormality (HP:0001969)2.08419286
39Abnormality of dentin (HP:0010299)2.07273055
40Focal motor seizures (HP:0011153)2.06813486
41Tubular atrophy (HP:0000092)2.05850619
42Abnormality of the lower motor neuron (HP:0002366)2.01579569
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8962608
44Abnormal respiratory motile cilium physiology (HP:0012261)11.7373324
45Dynein arm defect of respiratory motile cilia (HP:0012255)10.6838773
46Absent/shortened dynein arms (HP:0200106)10.6838773
47Abnormal ciliary motility (HP:0012262)10.6783174
48Genital tract atresia (HP:0001827)1.99118700
49Chronic hepatic failure (HP:0100626)1.97407199
50Aplasia/Hypoplasia of the spleen (HP:0010451)1.96229109
51Abnormality of the dental root (HP:0006486)1.95355217
52Taurodontia (HP:0000679)1.95355217
53Abnormality of permanent molar morphology (HP:0011071)1.95355217
54Bile duct proliferation (HP:0001408)1.95046145
55Abnormal biliary tract physiology (HP:0012439)1.95046145
56Oculomotor apraxia (HP:0000657)1.94250465
57Recurrent bronchitis (HP:0002837)1.91184599
58Vaginal atresia (HP:0000148)1.89117127
59Postaxial hand polydactyly (HP:0001162)1.88910154
60Asplenia (HP:0001746)1.87529914
61Poor coordination (HP:0002370)1.87172416
62Abnormality of molar morphology (HP:0011070)1.83598451
63Abnormality of molar (HP:0011077)1.83598451
64Abnormal spermatogenesis (HP:0008669)1.80025937
65Amelogenesis imperfecta (HP:0000705)1.78550766
66Abnormality of the dental pulp (HP:0006479)1.78516886
67Renal salt wasting (HP:0000127)1.76052419
68Type II lissencephaly (HP:0007260)1.75957185
69Stage 5 chronic kidney disease (HP:0003774)1.69729361
70Renal dysplasia (HP:0000110)1.62655021
71Hyperaldosteronism (HP:0000859)1.61747325
72Aplasia/Hypoplasia of the lens (HP:0008063)1.59350162
73Tubulointerstitial fibrosis (HP:0005576)1.56245846
74Abnormality of renin-angiotensin system (HP:0000847)1.56086373
75Hyperkalemia (HP:0002153)1.54683087
76Male pseudohermaphroditism (HP:0000037)1.54224369
77Preaxial hand polydactyly (HP:0001177)1.52332580
78Short ribs (HP:0000773)1.50831549
79Dyschromatopsia (HP:0007641)1.50380716
80Anencephaly (HP:0002323)1.44832892
81Cerebellar dysplasia (HP:0007033)1.44211670
82Amyotrophic lateral sclerosis (HP:0007354)1.43918696
83Abnormality of abdominal situs (HP:0011620)1.43845971
84Abdominal situs inversus (HP:0003363)1.43845971
85Microglossia (HP:0000171)1.43194629
86Azoospermia (HP:0000027)1.43183894
87Abnormality of the renal cortex (HP:0011035)1.42608571
88Polydipsia (HP:0001959)1.39802761
89Abnormal drinking behavior (HP:0030082)1.39802761
90Aplasia/Hypoplasia of the fibula (HP:0006492)1.39265413
91Prominent nasal bridge (HP:0000426)1.39120997
92Aganglionic megacolon (HP:0002251)1.36285567
93Decreased central vision (HP:0007663)1.35325507
94Multicystic kidney dysplasia (HP:0000003)1.35315215
95Sclerocornea (HP:0000647)1.34878353
96Nephropathy (HP:0000112)1.34468253
97Hypokalemic alkalosis (HP:0001949)1.33686767
98Abolished electroretinogram (ERG) (HP:0000550)1.31693735
99Narrow forehead (HP:0000341)1.31485291
100Polyuria (HP:0000103)1.30318783
101Gonadotropin excess (HP:0000837)1.29323786
102Abnormal rod and cone electroretinograms (HP:0008323)1.29198658
103Bell-shaped thorax (HP:0001591)1.28446560
104Absent speech (HP:0001344)1.27912502
105Specific learning disability (HP:0001328)1.27328343
10611 pairs of ribs (HP:0000878)1.27143075
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.27114583
108Bony spicule pigmentary retinopathy (HP:0007737)1.26410666
109Short thorax (HP:0010306)1.26035210
110Congenital stationary night blindness (HP:0007642)1.25230564
111Broad foot (HP:0001769)1.24235406
112Central scotoma (HP:0000603)1.23436957
113Impaired proprioception (HP:0010831)1.22723855
114Absent frontal sinuses (HP:0002688)1.21750476
115Polycystic kidney dysplasia (HP:0000113)1.18219343
116Holoprosencephaly (HP:0001360)1.17838327
117Retinitis pigmentosa (HP:0000510)1.17775748
118Constricted visual fields (HP:0001133)1.17558116
119Abnormality of saccadic eye movements (HP:0000570)1.16915151
120Abnormality of renal excretion (HP:0011036)1.16113018
121Bifid tongue (HP:0010297)1.15818619
122Abnormality of macular pigmentation (HP:0008002)1.15441780
123Highly arched eyebrow (HP:0002553)1.14040566
124Dandy-Walker malformation (HP:0001305)1.13548141
125J-shaped sella turcica (HP:0002680)1.13315306
126Focal seizures (HP:0007359)1.12961447
127Chorioretinal coloboma (HP:0000567)1.12849224
128Hypodontia (HP:0000668)1.12488003
129Atelectasis (HP:0100750)1.12295654
130Broad distal phalanx of finger (HP:0009836)1.12253623
131Furrowed tongue (HP:0000221)1.11342576
132Disproportionate short-trunk short stature (HP:0003521)1.10579169
133Abnormality of chloride homeostasis (HP:0011422)1.10576457
134Left ventricular hypertrophy (HP:0001712)1.09125562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.33754868
2PDK48.33754868
3PDK25.38115243
4PNCK4.93157778
5LATS14.49621024
6TESK13.35968616
7MAPK153.19802510
8PRKD33.04871720
9PTK2B2.63665426
10LATS22.44110277
11WNK42.28134222
12STK392.16895131
13EPHA22.15787424
14BMPR1B2.11514062
15ACVR1B2.04297112
16ICK1.95240670
17ZAK1.90129372
18MAP4K21.62808665
19MAPKAPK31.50664866
20NME11.50085103
21BCR1.49601191
22WEE11.47454309
23NLK1.31408780
24INSRR1.26557666
25STK381.19752265
26MAP3K21.19081386
27STK38L1.07276016
28GRK11.05730589
29OXSR11.04769334
30MAP3K41.02194102
31MAP2K71.02076070
32TLK11.00003851
33WNK10.99393644
34IRAK10.99350404
35NEK20.99084168
36MAP2K20.97039180
37CAMKK20.95830706
38TSSK60.94801708
39PDK10.89198563
40TYRO30.88667396
41LMTK20.78438043
42CSNK1G20.77250043
43IRAK20.75415896
44CSNK1A1L0.74426793
45PRKCI0.72948584
46PRKCG0.72583824
47EPHA30.71542335
48PRKAA20.69832484
49PINK10.68905437
50TNIK0.68130236
51DYRK20.67515837
52STK110.67111244
53MST40.66759924
54NTRK20.66095521
55STK160.64225366
56PAK30.64171563
57TTK0.63591656
58CCNB10.62603122
59FER0.61642296
60TGFBR10.61000861
61DYRK30.60939121
62STK30.58890517
63MELK0.57763800
64MKNK20.56149999
65EIF2AK30.55740575
66NEK60.54123040
67TRIM280.54032584
68PASK0.52156917
69CDK30.50417424
70GRK70.48795826
71CASK0.48025976
72CHEK20.48005552
73CSNK1G30.47380243
74CAMK1G0.47134931
75VRK10.47098551
76DYRK1B0.46816965
77AURKA0.45314424
78GRK50.42778376
79STK100.42233000
80CSNK1G10.41686910
81MUSK0.40413428
82MAPKAPK50.40303753
83BCKDK0.38639214
84PLK20.35862426
85SIK20.34314846
86PBK0.33365435
87MAP3K70.32947143
88BRSK20.32830131
89PLK40.32110475
90ATM0.31662600
91MAP3K120.31632029
92ERBB20.31462348
93PDPK10.30927604
94NUAK10.30507841
95ADRBK20.29903448
96CHEK10.29588283
97MINK10.29025949
98CAMKK10.28802245
99CDC70.28632338
100DYRK1A0.28438828
101CDK190.27927589
102PAK20.27077819
103NTRK30.26562988
104CAMK2G0.26013345
105CAMK2A0.24745530
106MARK10.24363034
107MYLK0.24223802
108EEF2K0.24063017
109CSNK1D0.23387505
110PRKCA0.23336317
111MAP2K10.22900080
112EPHA40.21263095
113BRAF0.20831598
114FRK0.20782304
115MARK30.20216870
116RPS6KB10.19661512
117MAP2K60.19256265
118PRKG10.18701177
119PAK10.18567826
120DAPK20.18368253
121AKT30.17837225
122BMPR20.16917774
123MAP2K40.16899974
124PRKACG0.16656763
125MAPK100.16574808
126PRKAA10.15863416
127PRKDC0.14793242
128WNK30.14716348
129ATR0.14182050
130ERBB30.14098377
131PRKCE0.13788222
132PLK10.13685062
133CDC42BPA0.13581473
134PRKACA0.13522032
135PRKCZ0.12693119
136PLK30.12504232
137CSNK1E0.11746903
138CDK50.11171514
139MAPK130.11107290
140ADRBK10.10836045
141CSNK2A10.10558231
142STK240.10225828
143CSNK2A20.10008973
144PRKCQ0.09110077
145RPS6KA20.08479847
146PRKCB0.08280482
147GSK3A0.08254281
148PHKG20.07841265
149PHKG10.07841265

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.69232325
2Pyruvate metabolism_Homo sapiens_hsa006203.64226475
3Huntingtons disease_Homo sapiens_hsa050163.11575531
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.09353055
5Phenylalanine metabolism_Homo sapiens_hsa003603.07781390
6Histidine metabolism_Homo sapiens_hsa003402.98573344
7Propanoate metabolism_Homo sapiens_hsa006402.60556905
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.49426073
9Glucagon signaling pathway_Homo sapiens_hsa049222.48992522
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.43945340
11beta-Alanine metabolism_Homo sapiens_hsa004102.37548558
12Dorso-ventral axis formation_Homo sapiens_hsa043202.35558766
13Tyrosine metabolism_Homo sapiens_hsa003502.34754595
14Amphetamine addiction_Homo sapiens_hsa050312.34629942
15Basal transcription factors_Homo sapiens_hsa030222.12988399
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.11244222
17Pentose phosphate pathway_Homo sapiens_hsa000302.04566165
18Caffeine metabolism_Homo sapiens_hsa002321.98286294
19Fatty acid biosynthesis_Homo sapiens_hsa000611.94654631
20Phototransduction_Homo sapiens_hsa047441.89947930
21Linoleic acid metabolism_Homo sapiens_hsa005911.86853576
22Fanconi anemia pathway_Homo sapiens_hsa034601.84968398
23Oocyte meiosis_Homo sapiens_hsa041141.81756139
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81596405
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80310396
26Renin secretion_Homo sapiens_hsa049241.79278928
27Butanoate metabolism_Homo sapiens_hsa006501.78191773
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73012225
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70388532
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68765630
31Olfactory transduction_Homo sapiens_hsa047401.67630761
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60019546
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57376336
34Cardiac muscle contraction_Homo sapiens_hsa042601.50607212
35Collecting duct acid secretion_Homo sapiens_hsa049661.49793582
36Long-term potentiation_Homo sapiens_hsa047201.42348895
37Glycerolipid metabolism_Homo sapiens_hsa005611.40315295
38Synaptic vesicle cycle_Homo sapiens_hsa047211.38664697
39Peroxisome_Homo sapiens_hsa041461.35595541
40Insulin secretion_Homo sapiens_hsa049111.32509615
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31659951
42PPAR signaling pathway_Homo sapiens_hsa033201.30716519
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30041984
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.29967726
45Nicotine addiction_Homo sapiens_hsa050331.26229307
46Nitrogen metabolism_Homo sapiens_hsa009101.26203202
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25137816
48Tryptophan metabolism_Homo sapiens_hsa003801.24826017
49ABC transporters_Homo sapiens_hsa020101.23468063
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.23343832
51Fatty acid degradation_Homo sapiens_hsa000711.21657372
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.21529248
53Ether lipid metabolism_Homo sapiens_hsa005651.16667364
54Calcium signaling pathway_Homo sapiens_hsa040201.14393941
55Circadian entrainment_Homo sapiens_hsa047131.14390536
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12957759
57Protein export_Homo sapiens_hsa030601.11442827
58Taste transduction_Homo sapiens_hsa047421.10747750
59Selenocompound metabolism_Homo sapiens_hsa004501.08753771
60Sulfur metabolism_Homo sapiens_hsa009201.08562723
61Estrogen signaling pathway_Homo sapiens_hsa049151.07155052
62Cocaine addiction_Homo sapiens_hsa050301.00880267
63Purine metabolism_Homo sapiens_hsa002300.99364785
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99213651
65Glutamatergic synapse_Homo sapiens_hsa047240.98366820
66Fructose and mannose metabolism_Homo sapiens_hsa000510.97989160
67Mineral absorption_Homo sapiens_hsa049780.97801973
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96966115
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95452861
70Circadian rhythm_Homo sapiens_hsa047100.93100551
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92709774
72Dopaminergic synapse_Homo sapiens_hsa047280.91596263
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.91576197
74Oxidative phosphorylation_Homo sapiens_hsa001900.90099533
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.89716948
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89297122
77Carbon metabolism_Homo sapiens_hsa012000.89274535
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85188279
79Gastric acid secretion_Homo sapiens_hsa049710.83221461
80Serotonergic synapse_Homo sapiens_hsa047260.82758886
81Basal cell carcinoma_Homo sapiens_hsa052170.81076910
82Renin-angiotensin system_Homo sapiens_hsa046140.76665174
83Thyroid hormone synthesis_Homo sapiens_hsa049180.75024025
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.74868182
85Antigen processing and presentation_Homo sapiens_hsa046120.73967025
86Salivary secretion_Homo sapiens_hsa049700.72911958
87Alzheimers disease_Homo sapiens_hsa050100.72792114
88Morphine addiction_Homo sapiens_hsa050320.71989795
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71357976
90Inositol phosphate metabolism_Homo sapiens_hsa005620.69796027
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69736099
92cAMP signaling pathway_Homo sapiens_hsa040240.67845885
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66662073
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64529951
95Hedgehog signaling pathway_Homo sapiens_hsa043400.64288295
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63532933
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63286781
98Arginine and proline metabolism_Homo sapiens_hsa003300.63229205
99Hippo signaling pathway_Homo sapiens_hsa043900.62446215
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.61983283
101mRNA surveillance pathway_Homo sapiens_hsa030150.60755960
102Regulation of autophagy_Homo sapiens_hsa041400.60562649
103Arachidonic acid metabolism_Homo sapiens_hsa005900.60182030
104Glutathione metabolism_Homo sapiens_hsa004800.59615684
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58400836
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58200413
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57826918
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57535035
109Parkinsons disease_Homo sapiens_hsa050120.57264400
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56357115
111Steroid biosynthesis_Homo sapiens_hsa001000.56135142
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52893066
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52476526
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49215025
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49104642
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48611326
117Chemical carcinogenesis_Homo sapiens_hsa052040.48605591
118N-Glycan biosynthesis_Homo sapiens_hsa005100.47946823
119Homologous recombination_Homo sapiens_hsa034400.46901033
120Fat digestion and absorption_Homo sapiens_hsa049750.46549934
121Biosynthesis of amino acids_Homo sapiens_hsa012300.45443446
122Oxytocin signaling pathway_Homo sapiens_hsa049210.44534594
123GABAergic synapse_Homo sapiens_hsa047270.43974225
124Vibrio cholerae infection_Homo sapiens_hsa051100.43344394
125Retinol metabolism_Homo sapiens_hsa008300.41211504
126Metabolic pathways_Homo sapiens_hsa011000.40523681
127Wnt signaling pathway_Homo sapiens_hsa043100.39932981
128Alcoholism_Homo sapiens_hsa050340.39758858
129Vitamin digestion and absorption_Homo sapiens_hsa049770.39055507
130Pancreatic secretion_Homo sapiens_hsa049720.37142008
131Ovarian steroidogenesis_Homo sapiens_hsa049130.35397788
132AMPK signaling pathway_Homo sapiens_hsa041520.33344122
133Starch and sucrose metabolism_Homo sapiens_hsa005000.31598552
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31376373
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30755003
136RNA polymerase_Homo sapiens_hsa030200.29852752
137Systemic lupus erythematosus_Homo sapiens_hsa053220.29136556
138Tight junction_Homo sapiens_hsa045300.28620741
139Sphingolipid metabolism_Homo sapiens_hsa006000.28106037
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28042240
141RNA transport_Homo sapiens_hsa030130.27655049
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25262743
143Fatty acid metabolism_Homo sapiens_hsa012120.24527523

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