CCDC114

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain-containing protein that is a component of the outer dynein arm docking complex in cilia cells. Mutations in this gene may cause primary ciliary dyskinesia 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.17169455
2regulation of cilium movement (GO:0003352)8.60184416
3primary alcohol catabolic process (GO:0034310)7.28514090
4vitamin transmembrane transport (GO:0035461)6.53136179
5microtubule bundle formation (GO:0001578)6.50288065
6ethanol metabolic process (GO:0006067)6.02419318
7diterpenoid biosynthetic process (GO:0016102)5.84252089
8tolerance induction (GO:0002507)5.52152952
9lung epithelium development (GO:0060428)5.28824252
10regulation of microtubule-based movement (GO:0060632)5.19830046
11negative regulation of T cell differentiation in thymus (GO:0033085)5.12965871
12pyrimidine-containing compound transmembrane transport (GO:0072531)5.10836055
13response to xenobiotic stimulus (GO:0009410)5.04501885
14central nervous system myelination (GO:0022010)5.02444350
15axon ensheathment in central nervous system (GO:0032291)5.02444350
16one-carbon compound transport (GO:0019755)5.02066507
17cellular component assembly involved in morphogenesis (GO:0010927)4.81102768
18negative regulation of immunoglobulin mediated immune response (GO:0002890)4.70970602
19negative regulation of B cell mediated immunity (GO:0002713)4.70970602
20microtubule-based movement (GO:0007018)4.66977008
21cilium morphogenesis (GO:0060271)4.66588928
22establishment of apical/basal cell polarity (GO:0035089)4.61377530
23sperm capacitation (GO:0048240)4.45620922
24glomerular epithelial cell development (GO:0072310)4.43443908
25ethanol oxidation (GO:0006069)4.42436904
26regulation of germinal center formation (GO:0002634)4.36878231
27cell projection assembly (GO:0030031)4.35797090
28negative regulation of humoral immune response (GO:0002921)4.28017500
29regulation of interleukin-5 production (GO:0032674)4.27303775
30terpenoid biosynthetic process (GO:0016114)4.21293160
31establishment of monopolar cell polarity (GO:0061162)4.18243430
32establishment or maintenance of monopolar cell polarity (GO:0061339)4.18243430
33retinoic acid metabolic process (GO:0042573)4.12390970
34presynaptic membrane assembly (GO:0097105)4.11135560
35positive regulation of tolerance induction (GO:0002645)4.07635432
36nucleoside diphosphate phosphorylation (GO:0006165)3.95141158
37cytoplasmic microtubule organization (GO:0031122)3.82354480
38negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.81567160
39exogenous drug catabolic process (GO:0042738)3.72011931
40presynaptic membrane organization (GO:0097090)3.71482982
41limb bud formation (GO:0060174)3.71302182
42regulation of interleukin-13 production (GO:0032656)3.68027596
43cilium or flagellum-dependent cell motility (GO:0001539)3.58372333
44long-chain fatty acid biosynthetic process (GO:0042759)3.55177328
45regulation of timing of cell differentiation (GO:0048505)3.54471618
46microtubule polymerization or depolymerization (GO:0031109)3.51230395
47sperm motility (GO:0030317)3.48994008
48cilium movement (GO:0003341)3.47957435
49negative regulation of inclusion body assembly (GO:0090084)3.43761002
50lateral ventricle development (GO:0021670)3.40840322
51establishment of tissue polarity (GO:0007164)3.37109792
52establishment of planar polarity (GO:0001736)3.37109792
53histone H2B ubiquitination (GO:0033523)3.33243051
54determination of left/right symmetry (GO:0007368)3.24357591
55GPI anchor biosynthetic process (GO:0006506)3.24357286
56cerebral cortex radially oriented cell migration (GO:0021799)3.21561700
57glutathione derivative metabolic process (GO:1901685)3.21382807
58glutathione derivative biosynthetic process (GO:1901687)3.21382807
59negative regulation of execution phase of apoptosis (GO:1900118)3.18777803
60primary alcohol metabolic process (GO:0034308)3.18095874
61retinol metabolic process (GO:0042572)3.14509522
62superoxide anion generation (GO:0042554)3.14210722
63mesenchymal cell differentiation involved in kidney development (GO:0072161)3.11899528
64mesenchymal cell differentiation involved in renal system development (GO:2001012)3.11899528
65epithelial cilium movement (GO:0003351)3.11451516
66determination of bilateral symmetry (GO:0009855)3.11144129
67positive regulation of smoothened signaling pathway (GO:0045880)3.07379350
68preassembly of GPI anchor in ER membrane (GO:0016254)3.05095843
69neuron cell-cell adhesion (GO:0007158)3.05042176
70specification of symmetry (GO:0009799)3.04320873
71O-glycan processing (GO:0016266)3.03032259
72GPI anchor metabolic process (GO:0006505)3.02941286
73regulation of development, heterochronic (GO:0040034)3.02749638
74hydrogen peroxide biosynthetic process (GO:0050665)3.02615355
75aldehyde catabolic process (GO:0046185)3.02549673
76smoothened signaling pathway (GO:0007224)2.99795110
77GTP biosynthetic process (GO:0006183)2.96011482
78regulation of tolerance induction (GO:0002643)2.95914075
79regulation of microtubule depolymerization (GO:0031114)2.93730882
80photoreceptor cell differentiation (GO:0046530)2.92072210
81eye photoreceptor cell differentiation (GO:0001754)2.92072210
82regulation of autophagic vacuole assembly (GO:2000785)2.91682606
83keratinocyte development (GO:0003334)2.91661170
84axoneme assembly (GO:0035082)2.89861006
85drug catabolic process (GO:0042737)2.89505248
86negative regulation of myoblast differentiation (GO:0045662)2.87399728
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86349385
88centriole assembly (GO:0098534)2.85747872
89microtubule-based process (GO:0007017)2.82750702
90* axonemal dynein complex assembly (GO:0070286)2.79351916
91lymphoid progenitor cell differentiation (GO:0002320)2.77089025
92intraciliary transport (GO:0042073)2.75893156
93nucleotide transmembrane transport (GO:1901679)2.75140648
94developmental pigmentation (GO:0048066)2.74746955
95oligodendrocyte differentiation (GO:0048709)2.72640783
96organelle assembly (GO:0070925)2.71267820
97reactive oxygen species biosynthetic process (GO:1903409)2.69459499
98cell proliferation in forebrain (GO:0021846)2.68454576
99regulation of pigment cell differentiation (GO:0050932)2.67958383
100negative regulation of neurotransmitter transport (GO:0051589)2.67886261
101startle response (GO:0001964)2.67430937
102postsynaptic membrane organization (GO:0001941)2.66180768
103positive regulation of action potential (GO:0045760)2.66109840
104apical protein localization (GO:0045176)2.65498805
105oligosaccharide biosynthetic process (GO:0009312)2.65386900
106centriole replication (GO:0007099)2.64165200
107protein localization to cilium (GO:0061512)2.63340409
108retina layer formation (GO:0010842)2.60643057
109carnitine metabolic process (GO:0009437)2.59822513
110positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.59169261
111righting reflex (GO:0060013)2.58719746
112excretion (GO:0007588)2.58365640
113spinal cord association neuron differentiation (GO:0021527)2.58362366
114female gonad development (GO:0008585)2.58206030
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.56928221
116phosphatidylcholine biosynthetic process (GO:0006656)2.56249842
117intra-S DNA damage checkpoint (GO:0031573)2.56164685
118nonmotile primary cilium assembly (GO:0035058)2.55153552
119polyol transport (GO:0015791)2.54456840
120multicellular organismal water homeostasis (GO:0050891)2.52429701
121negative regulation of neurotransmitter secretion (GO:0046929)2.52400444
122histone H3-K4 trimethylation (GO:0080182)2.52232229
123cornea development in camera-type eye (GO:0061303)2.50539974
124regulation of vacuole organization (GO:0044088)2.49920857
125retinal rod cell development (GO:0046548)2.49897200
126cilium assembly (GO:0042384)2.49388333
127left/right axis specification (GO:0070986)2.49148609
128hydrogen peroxide catabolic process (GO:0042744)2.48775949
129photoreceptor cell maintenance (GO:0045494)2.48086845
130detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47679098
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46220136
132embryonic camera-type eye development (GO:0031076)2.45138459
133motile cilium assembly (GO:0044458)2.44140071
134adenosine metabolic process (GO:0046085)2.44121092
135ventricular system development (GO:0021591)2.44037003
136mannosylation (GO:0097502)2.43276098
137regulation of activation of Janus kinase activity (GO:0010533)2.43208273
138oligosaccharide catabolic process (GO:0009313)2.43158037
139cilium organization (GO:0044782)2.42961647
140microtubule depolymerization (GO:0007019)2.41946293
141heart looping (GO:0001947)2.41664069
142myelination (GO:0042552)2.40943571
143positive regulation of cell fate commitment (GO:0010455)2.39741364
144glycerophospholipid catabolic process (GO:0046475)2.38897100
145kidney morphogenesis (GO:0060993)2.38423234
146calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.37907715
147epithelial cell differentiation involved in kidney development (GO:0035850)2.37815725
148neurotransmitter biosynthetic process (GO:0042136)2.37314534
149cell fate commitment involved in formation of primary germ layer (GO:0060795)2.35914047
150regulation of cilium assembly (GO:1902017)2.35231932
151forebrain neuron differentiation (GO:0021879)2.35081624
152spinal cord motor neuron differentiation (GO:0021522)2.35000439
153positive regulation of meiosis (GO:0045836)2.34070235
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33782202
155ensheathment of neurons (GO:0007272)2.33276765
156axon ensheathment (GO:0008366)2.33276765
157DNA ligation (GO:0006266)2.32345383
158import into cell (GO:0098657)2.28567783
159positive regulation of protein homodimerization activity (GO:0090073)2.26831507
160cell differentiation involved in kidney development (GO:0061005)2.26679893
161multicellular organism reproduction (GO:0032504)2.26447463
162regulation of respiratory gaseous exchange (GO:0043576)2.25299629
163reflex (GO:0060004)2.25177590
164acrosome reaction (GO:0007340)2.24547977
165positive regulation of synapse assembly (GO:0051965)2.23850918
166sympathetic nervous system development (GO:0048485)2.23848450
167mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.23505152
168cell differentiation in spinal cord (GO:0021515)2.22425725
169glycolipid biosynthetic process (GO:0009247)2.21831061
170lateral sprouting from an epithelium (GO:0060601)2.21524804
171DNA methylation involved in gamete generation (GO:0043046)2.21412896
172positive regulation of meiotic cell cycle (GO:0051446)2.21385588
173fatty acid elongation (GO:0030497)2.21327982
174transmission of nerve impulse (GO:0019226)2.21163325
175glucosamine-containing compound catabolic process (GO:1901072)2.20909703
176regulation of respiratory system process (GO:0044065)2.20836173
177regulation of feeding behavior (GO:0060259)2.20371631
178RNA destabilization (GO:0050779)2.19827925
179C-terminal protein lipidation (GO:0006501)2.19119743
180G-protein coupled receptor internalization (GO:0002031)2.17186240
181cranial nerve morphogenesis (GO:0021602)2.17084215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.23096060
2GBX2_23144817_ChIP-Seq_PC3_Human3.86196100
3* DROSHA_22980978_ChIP-Seq_HELA_Human3.23245611
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.12825831
5EZH2_22144423_ChIP-Seq_EOC_Human3.11747397
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86889304
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79193082
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66809930
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61398975
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.57312687
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.54557873
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40609350
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38347162
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.37752254
15TAF15_26573619_Chip-Seq_HEK293_Human2.37697987
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34430463
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.29450509
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.18604592
19VDR_22108803_ChIP-Seq_LS180_Human2.16050431
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.15406751
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15242551
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10647287
23SUZ12_27294783_Chip-Seq_NPCs_Mouse2.08384310
24AHR_22903824_ChIP-Seq_MCF-7_Human2.04238337
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.02956347
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.00204597
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.95279753
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93698688
29P300_19829295_ChIP-Seq_ESCs_Human1.85688569
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.85082202
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84384816
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83088915
33RNF2_27304074_Chip-Seq_NSC_Mouse1.82869812
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81923691
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.81291459
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81061227
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79064765
38FUS_26573619_Chip-Seq_HEK293_Human1.78433426
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.77927581
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.77688177
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.76823186
42STAT1_20625510_ChIP-Seq_HELA_Human1.74913096
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74295120
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.73484063
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.69763654
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69677167
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.69062573
48P53_22387025_ChIP-Seq_ESCs_Mouse1.68568798
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67728387
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.66087850
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65403991
52P300_18555785_Chip-Seq_ESCs_Mouse1.65160835
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64894852
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.64014785
55SMC4_20622854_ChIP-Seq_HELA_Human1.62762532
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.62405384
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62197836
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61861698
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61447132
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61154028
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60576502
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59589954
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.59535973
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58247538
65ER_23166858_ChIP-Seq_MCF-7_Human1.58111760
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.55908350
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.55684678
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55651460
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55629369
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54899479
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54711393
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53746817
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53584250
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52080553
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51286012
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50159739
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.49940119
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.49707052
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.49329581
80AR_21572438_ChIP-Seq_LNCaP_Human1.49110617
81TP63_23658742_ChIP-Seq_EP156T_Human1.48461079
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48246023
83* RUNX1_27514584_Chip-Seq_MCF-7_Human1.47756967
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.47129806
85KLF4_18555785_Chip-Seq_ESCs_Mouse1.46533843
86IRF1_19129219_ChIP-ChIP_H3396_Human1.46078790
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.45464342
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45372512
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45372512
90IGF1R_20145208_ChIP-Seq_DFB_Human1.44712606
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.44650968
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44061934
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.43987139
94ETV1_20927104_ChIP-Seq_GIST48_Human1.43802994
95EWS_26573619_Chip-Seq_HEK293_Human1.43141409
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42886196
97TP63_22573176_ChIP-Seq_HFKS_Human1.40866247
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.39819985
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38911687
100SMAD1_18555785_Chip-Seq_ESCs_Mouse1.37867078
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36924063
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35885253
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35270256
104SMRT_27268052_Chip-Seq_Bcells_Human1.33898021
105PU1_27457419_Chip-Seq_LIVER_Mouse1.33762108
106SMAD4_21799915_ChIP-Seq_A2780_Human1.33679775
107PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33629845
108FOXA1_25552417_ChIP-Seq_VCAP_Human1.32234960
109PHF8_20622853_ChIP-Seq_HELA_Human1.32155419
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31881910
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.31107133
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31106693
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.31036231
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29997964
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29393323
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29190124
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.27194865
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26350531
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26262730
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26262730
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25594356
122P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24814204
123* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24742639
124* KLF5_25053715_ChIP-Seq_YYC3_Human1.24657673
125CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24434069
126HNFA_21074721_ChIP-Seq_CACO-2_Human1.23757618
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22997397
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.21784717
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21609030
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20223964
131SMAD_19615063_ChIP-ChIP_OVARY_Human1.20146867
132MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20098689
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19915743
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19574653
135RBPJ_21746931_ChIP-Seq_IB4_Human1.18897388
136CTCF_27219007_Chip-Seq_Bcells_Human1.18729850
137BCAT_22108803_ChIP-Seq_LS180_Human1.17348881
138SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17059354
139* CTCF_20526341_ChIP-Seq_ESCs_Human1.14875124
140CDX2_20551321_ChIP-Seq_CACO-2_Human1.14579317
141* ELF1_20517297_ChIP-Seq_JURKAT_Human1.14352441
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14264484
143TP53_18474530_ChIP-ChIP_U2OS_Human1.13950963
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12417511
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12199420
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11973149
147RUNX2_22187159_ChIP-Seq_PCA_Human1.11594386
148CBX2_22325352_ChIP-Seq_293T-Rex_Human1.10857488
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10723105
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10523356
151KDM2B_26808549_Chip-Seq_REH_Human1.10443743
152SOX2_20726797_ChIP-Seq_SW620_Human1.09632780
153* PHF8_20622854_ChIP-Seq_HELA_Human1.08931925
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08625153
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08047159
156TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08029809
157FOXA1_25329375_ChIP-Seq_VCAP_Human1.07615223
158FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07615223
159NFYA_21822215_ChIP-Seq_K562_Human1.07098133
160GATA6_21074721_ChIP-Seq_CACO-2_Human1.07011270
161SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06712036
162TCF4_23295773_ChIP-Seq_U87_Human1.06683423
163GATA4_25053715_ChIP-Seq_YYC3_Human1.05416756
164OCT4_20526341_ChIP-Seq_ESCs_Human1.05322298
165STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03643646
166GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03066902
167CEBPB_22108803_ChIP-Seq_LS180_Human1.02984163
168VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02066020
169AR_20517297_ChIP-Seq_VCAP_Human1.01857203
170TBL1_22424771_ChIP-Seq_293T_Human1.00210842
171NFYB_21822215_ChIP-Seq_K562_Human0.99482886
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.98395501
173TP53_16413492_ChIP-PET_HCT116_Human0.97633897
174WDR5_24793694_ChIP-Seq_LNCAP_Human0.97327044
175* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97085595
176SMAD4_21741376_ChIP-Seq_EPCs_Human0.97041700
177* P68_20966046_ChIP-Seq_HELA_Human0.96295417
178* MYC_19829295_ChIP-Seq_ESCs_Human0.96048089
179TCF4_22108803_ChIP-Seq_LS180_Human0.95792322
180NCOR_22424771_ChIP-Seq_293T_Human0.94928727
181GATA1_19941826_ChIP-Seq_K562_Human0.94883529
182FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94707523
183* P300_27268052_Chip-Seq_Bcells_Human0.93322696
184STAT3_23295773_ChIP-Seq_U87_Human0.92823523
185BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91577205
186RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91125858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology7.14159817
2MP0008875_abnormal_xenobiotic_pharmacok6.91713716
3MP0003136_yellow_coat_color4.29901641
4MP0004043_abnormal_pH_regulation3.77751848
5MP0009780_abnormal_chondrocyte_physiolo3.59940659
6MP0001188_hyperpigmentation3.32741519
7MP0003880_abnormal_central_pattern3.27031465
8MP0006292_abnormal_olfactory_placode3.19370290
9MP0000566_synostosis3.02258190
10MP0005623_abnormal_meninges_morphology2.79374418
11MP0002102_abnormal_ear_morphology2.74108403
12MP0005409_darkened_coat_color2.68951616
13MP0004381_abnormal_hair_follicle2.50385867
14MP0005171_absent_coat_pigmentation2.34540939
15MP0002160_abnormal_reproductive_system2.32977474
16MP0002282_abnormal_trachea_morphology2.21640248
17MP0005499_abnormal_olfactory_system2.16750572
18MP0005394_taste/olfaction_phenotype2.16750572
19MP0004742_abnormal_vestibular_system2.11888959
20MP0002277_abnormal_respiratory_mucosa2.09379432
21MP0001486_abnormal_startle_reflex2.04791208
22MP0004019_abnormal_vitamin_homeostasis2.02707128
23MP0010678_abnormal_skin_adnexa2.00246486
24MP0005083_abnormal_biliary_tract2.00062116
25MP0001986_abnormal_taste_sensitivity1.93898270
26MP0005423_abnormal_somatic_nervous1.93679218
27MP0001905_abnormal_dopamine_level1.93066876
28MP0002638_abnormal_pupillary_reflex1.85869719
29MP0005379_endocrine/exocrine_gland_phen1.83943721
30MP0005645_abnormal_hypothalamus_physiol1.83838260
31MP0002168_other_aberrant_phenotype1.82275409
32MP0001529_abnormal_vocalization1.75783171
33MP0001984_abnormal_olfaction1.74121111
34MP0005646_abnormal_pituitary_gland1.71479163
35MP0001765_abnormal_ion_homeostasis1.70221067
36MP0000015_abnormal_ear_pigmentation1.61789231
37MP0009379_abnormal_foot_pigmentation1.61667540
38MP0005410_abnormal_fertilization1.56448891
39MP0003656_abnormal_erythrocyte_physiolo1.56159372
40MP0000026_abnormal_inner_ear1.55702676
41MP0005551_abnormal_eye_electrophysiolog1.51750248
42MP0002909_abnormal_adrenal_gland1.50572526
43MP0005174_abnormal_tail_pigmentation1.50024947
44MP0003938_abnormal_ear_development1.49505841
45MP0001485_abnormal_pinna_reflex1.48977693
46MP0002272_abnormal_nervous_system1.46441804
47MP0000920_abnormal_myelination1.45319172
48MP0004142_abnormal_muscle_tone1.43252690
49MP0000778_abnormal_nervous_system1.42977665
50MP0001963_abnormal_hearing_physiology1.36446600
51MP0009046_muscle_twitch1.34835802
52MP0002163_abnormal_gland_morphology1.33363319
53MP0006276_abnormal_autonomic_nervous1.32664149
54MP0000049_abnormal_middle_ear1.31562806
55MP0010386_abnormal_urinary_bladder1.29847539
56MP0009745_abnormal_behavioral_response1.29354907
57MP0002938_white_spotting1.29234115
58MP0000372_irregular_coat_pigmentation1.28453821
59MP0003941_abnormal_skin_development1.26914018
60MP0005389_reproductive_system_phenotype1.25999765
61MP0001346_abnormal_lacrimal_gland1.24472566
62MP0000678_abnormal_parathyroid_gland1.23489826
63MP0005395_other_phenotype1.22306140
64MP0005248_abnormal_Harderian_gland1.21781149
65MP0002572_abnormal_emotion/affect_behav1.21554592
66MP0003878_abnormal_ear_physiology1.21433542
67MP0005377_hearing/vestibular/ear_phenot1.21433542
68MP0002734_abnormal_mechanical_nocicepti1.19326322
69MP0005253_abnormal_eye_physiology1.17854048
70MP0000631_abnormal_neuroendocrine_gland1.16646355
71MP0010030_abnormal_orbit_morphology1.16618357
72MP0005636_abnormal_mineral_homeostasis1.14853751
73MP0008057_abnormal_DNA_replication1.14590805
74MP0008995_early_reproductive_senescence1.13042557
75MP0002735_abnormal_chemical_nociception1.12615986
76MP0008058_abnormal_DNA_repair1.11001908
77MP0003724_increased_susceptibility_to1.10877834
78MP0002557_abnormal_social/conspecific_i1.10565986
79MP0005075_abnormal_melanosome_morpholog1.10546022
80MP0001440_abnormal_grooming_behavior1.08732062
81MP0002067_abnormal_sensory_capabilities1.08703866
82MP0002752_abnormal_somatic_nervous1.08654695
83MP0000383_abnormal_hair_follicle1.07865499
84MP0001968_abnormal_touch/_nociception1.07697460
85MP0006072_abnormal_retinal_apoptosis1.07016676
86MP0003787_abnormal_imprinting1.05796978
87MP0001929_abnormal_gametogenesis1.05428821
88MP0002233_abnormal_nose_morphology1.04797238
89MP0002132_abnormal_respiratory_system1.03720503
90MP0003937_abnormal_limbs/digits/tail_de1.02600790
91MP0008789_abnormal_olfactory_epithelium1.01342953
92MP0004270_analgesia1.00516847
93MP0002736_abnormal_nociception_after0.98957710
94MP0002064_seizures0.97951922
95MP0005165_increased_susceptibility_to0.97617149
96MP0003718_maternal_effect0.97337152
97MP0001501_abnormal_sleep_pattern0.96837945
98MP0003950_abnormal_plasma_membrane0.95486373
99MP0000762_abnormal_tongue_morphology0.95080068
100MP0002249_abnormal_larynx_morphology0.94896351
101MP0009250_abnormal_appendicular_skeleto0.94891127
102MP0002148_abnormal_hypersensitivity_rea0.93769443
103MP0000465_gastrointestinal_hemorrhage0.93555814
104MP0002095_abnormal_skin_pigmentation0.92942618
105MP0000462_abnormal_digestive_system0.91629443
106MP0002876_abnormal_thyroid_physiology0.89745916
107MP0002177_abnormal_outer_ear0.89267866
108MP0002751_abnormal_autonomic_nervous0.88138225
109MP0008872_abnormal_physiological_respon0.87050897
110MP0004133_heterotaxia0.85470212
111MP0002822_catalepsy0.85346521
112MP0003635_abnormal_synaptic_transmissio0.85192956
113MP0010155_abnormal_intestine_physiology0.85106824
114MP0001502_abnormal_circadian_rhythm0.82466043
115MP0005195_abnormal_posterior_eye0.82083471
116MP0005365_abnormal_bile_salt0.81229936
117MP0005451_abnormal_body_composition0.80188622
118MP0002184_abnormal_innervation0.80025973
119MP0004885_abnormal_endolymph0.79195435
120MP0001270_distended_abdomen0.78872605
121MP0005220_abnormal_exocrine_pancreas0.78448544
122MP0000613_abnormal_salivary_gland0.78081460
123MP0003698_abnormal_male_reproductive0.77056322
124MP0001970_abnormal_pain_threshold0.76925795
125MP0001286_abnormal_eye_development0.76804855
126MP0009643_abnormal_urine_homeostasis0.75703593
127MP0008260_abnormal_autophagy0.75154316
128MP0002882_abnormal_neuron_morphology0.74800866
129MP0003690_abnormal_glial_cell0.74327891
130MP0002136_abnormal_kidney_physiology0.73719743
131MP0001324_abnormal_eye_pigmentation0.73545459
132MP0001664_abnormal_digestion0.72912578
133MP0005408_hypopigmentation0.71704483
134MP0004134_abnormal_chest_morphology0.71352241
135MP0002063_abnormal_learning/memory/cond0.70940778
136MP0008877_abnormal_DNA_methylation0.70546649
137MP0001293_anophthalmia0.70226129
138MP0000681_abnormal_thyroid_gland0.64944152
139MP0002928_abnormal_bile_duct0.63235820
140MP0001944_abnormal_pancreas_morphology0.62414863
141MP0003195_calcinosis0.61813669
142MP0002229_neurodegeneration0.60226499
143MP0004264_abnormal_extraembryonic_tissu0.59397197
144MP0002098_abnormal_vibrissa_morphology0.59317763
145MP0003890_abnormal_embryonic-extraembry0.58597182
146MP0005164_abnormal_response_to0.57515747
147MP0010234_abnormal_vibrissa_follicle0.57457249
148MP0002139_abnormal_hepatobiliary_system0.56469840
149MP0005085_abnormal_gallbladder_physiolo0.54762377
150MP0002116_abnormal_craniofacial_bone0.53601398
151MP0002161_abnormal_fertility/fecundity0.51926268
152MP0004883_abnormal_blood_vessel0.51300542
153MP0006036_abnormal_mitochondrial_physio0.50329207
154MP0005503_abnormal_tendon_morphology0.48325446
155MP0000467_abnormal_esophagus_morphology0.47632139
156MP0005391_vision/eye_phenotype0.47436787
157MP0002405_respiratory_system_inflammati0.47358316
158MP0002135_abnormal_kidney_morphology0.43579610
159MP0009765_abnormal_xenobiotic_induced0.43552002
160MP0003866_abnormal_defecation0.43348086
161MP0000955_abnormal_spinal_cord0.42343336

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.12885827
2* Bronchiectasis (HP:0002110)7.44840522
3Nasal polyposis (HP:0100582)7.08652827
4Abnormality of the nasal mucosa (HP:0000433)5.85768015
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.67136524
6Bronchitis (HP:0012387)4.59684506
7Infertility (HP:0000789)4.53510178
8Chronic sinusitis (HP:0011109)4.23602617
9Chromsome breakage (HP:0040012)4.03063433
10Male infertility (HP:0003251)3.99413538
11Occipital encephalocele (HP:0002085)3.98129351
12Parakeratosis (HP:0001036)3.70638241
13* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.66483336
14* Recurrent sinusitis (HP:0011108)3.60833692
15Duplicated collecting system (HP:0000081)3.60398660
16* Recurrent otitis media (HP:0000403)3.60158443
17* Abnormal respiratory motile cilium physiology (HP:0012261)3.47841909
18* Abnormal ciliary motility (HP:0012262)3.39964851
19Abnormality of the renal collecting system (HP:0004742)3.29578114
20Cystic liver disease (HP:0006706)3.25251711
21Chronic otitis media (HP:0000389)3.22170517
22Hyperactive renin-angiotensin system (HP:0000841)3.04149994
23Patchy hypopigmentation of hair (HP:0011365)2.74514586
24Chronic hepatic failure (HP:0100626)2.71830503
25Septo-optic dysplasia (HP:0100842)2.67374837
26White forelock (HP:0002211)2.66722669
27* Abnormal respiratory epithelium morphology (HP:0012253)2.66045102
28* Abnormal respiratory motile cilium morphology (HP:0005938)2.66045102
29Nephronophthisis (HP:0000090)2.62901274
30* Absent/shortened dynein arms (HP:0200106)2.61290882
31* Dynein arm defect of respiratory motile cilia (HP:0012255)2.61290882
32Rhinitis (HP:0012384)2.56209187
33Duplication of thumb phalanx (HP:0009942)2.55992899
34Medial flaring of the eyebrow (HP:0010747)2.51263277
35Prostate neoplasm (HP:0100787)2.50693719
36Abnormality of the axillary hair (HP:0100134)2.47400207
37Abnormality of secondary sexual hair (HP:0009888)2.47400207
38True hermaphroditism (HP:0010459)2.41040073
39Hypothermia (HP:0002045)2.38667366
40Upper limb muscle weakness (HP:0003484)2.36480573
41Aplasia cutis congenita (HP:0001057)2.34506746
42Anencephaly (HP:0002323)2.33689759
43Abnormality of the renal medulla (HP:0100957)2.30643822
44Median cleft lip (HP:0000161)2.30429380
45Congenital hepatic fibrosis (HP:0002612)2.27447512
46Tubulointerstitial nephritis (HP:0001970)2.26945892
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22520524
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.21434257
49Renal Fanconi syndrome (HP:0001994)2.19521678
50Abnormality of the preputium (HP:0100587)2.17889094
51Abnormal hair whorl (HP:0010721)2.17295981
52Recurrent bronchitis (HP:0002837)2.16858598
53Pancreatic fibrosis (HP:0100732)2.14146011
54Optic nerve hypoplasia (HP:0000609)2.12791853
55Nephrogenic diabetes insipidus (HP:0009806)2.12776498
56Febrile seizures (HP:0002373)2.12571544
57Cupped ear (HP:0000378)2.12534222
58Decreased central vision (HP:0007663)2.10322711
59Absent septum pellucidum (HP:0001331)2.09960948
60Male pseudohermaphroditism (HP:0000037)2.09303077
613-Methylglutaconic aciduria (HP:0003535)2.09202098
62Conical tooth (HP:0000698)2.08830031
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.07098887
64Gait imbalance (HP:0002141)2.06723180
65Bell-shaped thorax (HP:0001591)2.06056112
66Adrenal hypoplasia (HP:0000835)2.05768982
67Preaxial hand polydactyly (HP:0001177)2.05712035
68Abnormality of DNA repair (HP:0003254)2.04542586
69Congenital primary aphakia (HP:0007707)2.03557785
70Meckel diverticulum (HP:0002245)2.02872998
71Osteomalacia (HP:0002749)2.02796924
72Degeneration of the lateral corticospinal tracts (HP:0002314)2.02623642
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02623642
74Tubular atrophy (HP:0000092)2.00678465
75Abnormality of incisor morphology (HP:0011063)2.00435427
76Abnormality of the septum pellucidum (HP:0007375)2.00390171
77Ectopic kidney (HP:0000086)2.00111397
78Asplenia (HP:0001746)1.99876829
79Abnormality of molar morphology (HP:0011070)1.99336596
80Abnormality of molar (HP:0011077)1.99336596
81Decreased circulating renin level (HP:0003351)1.98791075
82Postaxial foot polydactyly (HP:0001830)1.97086737
83Renal salt wasting (HP:0000127)1.95973888
84Abnormality of midbrain morphology (HP:0002418)1.95917860
85Molar tooth sign on MRI (HP:0002419)1.95917860
86Sclerocornea (HP:0000647)1.95615072
87Abnormality of the ileum (HP:0001549)1.95137275
88Increased hepatocellular lipid droplets (HP:0006565)1.95106376
89Anomalous pulmonary venous return (HP:0010772)1.93287257
90Clubbing of toes (HP:0100760)1.92792924
91Nephroblastoma (Wilms tumor) (HP:0002667)1.92673902
92Congenital sensorineural hearing impairment (HP:0008527)1.92578305
93Furrowed tongue (HP:0000221)1.92260847
94Aplasia/Hypoplasia of the lens (HP:0008063)1.91029735
95Pancreatic cysts (HP:0001737)1.89038818
96Genital tract atresia (HP:0001827)1.86272211
97Attenuation of retinal blood vessels (HP:0007843)1.85573085
98Abnormality of renal resorption (HP:0011038)1.84364577
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.84180541
100Vaginal atresia (HP:0000148)1.83449750
101Oculomotor apraxia (HP:0000657)1.83285705
102Aplasia/Hypoplasia of the fovea (HP:0008060)1.81208017
103Hypoplasia of the fovea (HP:0007750)1.81208017
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.80656291
105* Atelectasis (HP:0100750)1.79876144
106Embryonal renal neoplasm (HP:0011794)1.79748534
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77400809
108Abnormality of permanent molar morphology (HP:0011071)1.77106330
109Abnormality of the dental root (HP:0006486)1.77106330
110Taurodontia (HP:0000679)1.77106330
111Postaxial hand polydactyly (HP:0001162)1.76862819
112Reticulocytopenia (HP:0001896)1.76770462
113Absent frontal sinuses (HP:0002688)1.76614389
114Abnormality of the dental pulp (HP:0006479)1.74803333
115Triphalangeal thumb (HP:0001199)1.74761835
116Nephropathy (HP:0000112)1.74658711
117Abnormality of the pulmonary veins (HP:0011718)1.72795980
118Aganglionic megacolon (HP:0002251)1.72143599
119Stomach cancer (HP:0012126)1.71433647
120Congenital stationary night blindness (HP:0007642)1.71346507
121Increased corneal curvature (HP:0100692)1.70122760
122Keratoconus (HP:0000563)1.70122760
123Retrobulbar optic neuritis (HP:0100654)1.70063701
124Optic neuritis (HP:0100653)1.70063701
125Abnormality of chromosome stability (HP:0003220)1.69107567
126Hyperkalemia (HP:0002153)1.69025351
127Nasolacrimal duct obstruction (HP:0000579)1.68774742
128Overfolded helix (HP:0000396)1.68168994
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68121742
130Obstructive lung disease (HP:0006536)1.67633377
131Chronic obstructive pulmonary disease (HP:0006510)1.67633377
132Hyperaldosteronism (HP:0000859)1.64305697
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56822306
134Tubulointerstitial abnormality (HP:0001969)1.49000096
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48166306
136Abnormality of renin-angiotensin system (HP:0000847)1.47281837
137Abnormality of chloride homeostasis (HP:0011422)1.46620142
138Poor coordination (HP:0002370)1.38017194
139Stage 5 chronic kidney disease (HP:0003774)1.34601282
140Hypokalemic alkalosis (HP:0001949)1.34480582
141Short thorax (HP:0010306)1.32797735
142Fetal akinesia sequence (HP:0001989)1.31073450
143Polydipsia (HP:0001959)1.28806899
144Abnormal drinking behavior (HP:0030082)1.28806899
145Bile duct proliferation (HP:0001408)1.25642417
146Abnormal biliary tract physiology (HP:0012439)1.25642417
147Abnormality of the frontal sinuses (HP:0002687)1.24612555
148Abnormal rod and cone electroretinograms (HP:0008323)1.23293674
149Abnormality of the renal cortex (HP:0011035)1.23024113
150Absent speech (HP:0001344)1.21504447
151Tubulointerstitial fibrosis (HP:0005576)1.20278344
152Hand muscle atrophy (HP:0009130)1.19597450
153Glucose intolerance (HP:0000833)1.17959399
154Retinitis pigmentosa (HP:0000510)1.17011851
155Short femoral neck (HP:0100864)1.16783436
156Aplasia of the musculature (HP:0100854)1.16158602
157Hyponatremia (HP:0002902)1.15349239
158Abnormality of the distal phalanges of the toes (HP:0010182)1.13902815
159Bifid scrotum (HP:0000048)1.13767137
160Cone-rod dystrophy (HP:0000548)1.13565245
161Carpal bone hypoplasia (HP:0001498)1.13225743
162Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.11838459
163Supernumerary spleens (HP:0009799)1.06208168
164Spinal muscular atrophy (HP:0007269)1.05635094
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.03973132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.23925565
2CASK3.90437728
3TNIK3.35071529
4STK163.32041396
5STK392.53485406
6MAPKAPK32.53379317
7NME12.25769429
8NEK61.97107482
9NUAK11.93865962
10BMPR1B1.89801384
11OXSR11.89223586
12IRAK41.84650926
13PKN11.75308367
14PNCK1.74959361
15IRAK31.73265640
16YES11.72611245
17MKNK21.69876223
18STK241.69135263
19TXK1.67659669
20MAP2K71.67236214
21EEF2K1.66375418
22ZAK1.66013032
23MAP3K21.64623476
24PTK2B1.64155834
25ADRBK21.62359186
26MUSK1.58471741
27PBK1.49685632
28BMPR21.46411978
29MAP3K141.45891294
30EIF2AK21.45542444
31SMG11.44623924
32TTK1.43471328
33MST41.42020029
34MAPK151.40348087
35GRK11.39696180
36GRK71.39343932
37CSK1.38593187
38IRAK21.35939452
39BCR1.34721749
40SRPK11.32082555
41INSRR1.29437299
42MAPK131.26370617
43TNK21.23677914
44MKNK11.22760779
45BLK1.16515875
46IRAK11.16385798
47CDK31.16263616
48TEC1.15897512
49MAP3K31.15626079
50FGR1.13930311
51VRK11.12966412
52CLK11.11797073
53MAP3K41.05607792
54PRKCI1.01693252
55EPHA41.01692802
56MAP3K70.99763467
57PRPF4B0.98155466
58PIK3CA0.96135349
59DYRK20.95482921
60MAP4K20.90246155
61MAPKAPK50.89689190
62STK100.88109744
63WNK40.87187740
64EPHA30.82811988
65PRKCE0.82025455
66TLK10.80421824
67MARK20.78460002
68NLK0.78042409
69TIE10.77572798
70STK380.77529919
71RIPK40.77236219
72LRRK20.77119960
73NTRK20.77089674
74FRK0.76491996
75MST1R0.75278884
76AKT30.75076127
77BRD40.74460138
78PINK10.74430478
79TBK10.73301176
80CSNK1A1L0.72255109
81MARK10.70093430
82CAMK2B0.68992110
83CDK190.64542121
84CSNK1G10.63702441
85WNK10.62842957
86NTRK30.62579908
87CAMK2A0.61993339
88STK38L0.61498572
89CSNK1G30.60114344
90CAMKK10.60080236
91ERBB20.59234152
92LATS10.59072935
93PRKCQ0.58565247
94BRSK20.56233843
95SGK4940.56012040
96SGK2230.56012040
97LYN0.54188373
98FES0.54168491
99RPS6KA50.54039819
100CAMK2D0.53758717
101IKBKB0.53623857
102DYRK1A0.52463196
103UHMK10.52344463
104PLK20.50698710
105GRK60.49643517
106SIK30.49580687
107SIK20.48500757
108TESK10.47978802
109MAPK70.47965427
110TRPM70.47509586
111IKBKE0.47009171
112PLK40.46721776
113PRKG10.46223054
114PRKD20.45194668
115MET0.45015969
116CHEK20.43763335
117PRKCD0.43103434
118ROCK20.42898190
119MAP3K120.41936646
120PRKAA20.41152858
121AURKA0.41025841
122CDK80.40778250
123FER0.40732862
124MAP2K40.40403303
125EPHB20.39621200
126SGK10.38467243
127ADRBK10.37902073
128LCK0.34893455
129ERBB30.34084882
130EPHB10.34033360
131CAMK2G0.33581474
132PRKACA0.33288698
133WNK30.32549419
134CSNK1A10.32255619
135BTK0.31301128
136DYRK1B0.30577701
137HIPK20.28050810
138PRKCA0.25544815
139RPS6KB20.25299209
140ABL10.25285710
141PDPK10.24488658
142MAP2K20.24484467
143PRKCZ0.24229576
144PLK10.21652188
145ROCK10.17797817
146RPS6KA20.17271531
147PRKAA10.16857320
148PASK0.14256393
149PRKD30.13913043
150CDC42BPA0.13502664
151RPS6KB10.12829065
152AKT20.12326552
153PRKCH0.12017103
154MYLK0.11960695
155ICK0.11682341
156EGFR0.11349998
157CSNK1G20.10073295
158IGF1R0.09670303
159SRC0.08493078

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.41995193
2Phenylalanine metabolism_Homo sapiens_hsa003604.73152538
3Chemical carcinogenesis_Homo sapiens_hsa052044.50647358
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.19600737
5Tyrosine metabolism_Homo sapiens_hsa003503.71625884
6beta-Alanine metabolism_Homo sapiens_hsa004102.99641410
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66661312
8Glutathione metabolism_Homo sapiens_hsa004802.48122150
9Fanconi anemia pathway_Homo sapiens_hsa034602.46836353
10Caffeine metabolism_Homo sapiens_hsa002322.42064359
11Nicotine addiction_Homo sapiens_hsa050332.29952628
12Phototransduction_Homo sapiens_hsa047442.23099888
13Oxidative phosphorylation_Homo sapiens_hsa001902.20434649
14Ether lipid metabolism_Homo sapiens_hsa005652.08663746
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.08123217
16Sphingolipid metabolism_Homo sapiens_hsa006001.97851673
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96336031
18Steroid biosynthesis_Homo sapiens_hsa001001.81802359
19Autoimmune thyroid disease_Homo sapiens_hsa053201.69676699
20Homologous recombination_Homo sapiens_hsa034401.58897325
21Graft-versus-host disease_Homo sapiens_hsa053321.58520773
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56125046
23Protein export_Homo sapiens_hsa030601.55293082
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54368979
25Serotonergic synapse_Homo sapiens_hsa047261.53780781
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53572602
27Arachidonic acid metabolism_Homo sapiens_hsa005901.51759314
28Non-homologous end-joining_Homo sapiens_hsa034501.50684279
29Fatty acid elongation_Homo sapiens_hsa000621.49731191
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48892471
31RNA polymerase_Homo sapiens_hsa030201.48395148
32Taste transduction_Homo sapiens_hsa047421.47398692
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46273962
34ABC transporters_Homo sapiens_hsa020101.43921244
35Alzheimers disease_Homo sapiens_hsa050101.42336276
36Parkinsons disease_Homo sapiens_hsa050121.41237639
37Rheumatoid arthritis_Homo sapiens_hsa053231.38432934
38Linoleic acid metabolism_Homo sapiens_hsa005911.35783499
39Allograft rejection_Homo sapiens_hsa053301.34165882
40Huntingtons disease_Homo sapiens_hsa050161.34102054
41Basal transcription factors_Homo sapiens_hsa030221.32279477
42Morphine addiction_Homo sapiens_hsa050321.31319458
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28544388
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27824371
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26438017
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24861297
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24672707
48Peroxisome_Homo sapiens_hsa041461.23314996
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21430618
50Tight junction_Homo sapiens_hsa045301.21078158
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18623909
52Fatty acid degradation_Homo sapiens_hsa000711.17547958
53Axon guidance_Homo sapiens_hsa043601.13939918
54Glutamatergic synapse_Homo sapiens_hsa047241.13144193
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12292021
56Ribosome_Homo sapiens_hsa030101.11600726
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10820875
58Asthma_Homo sapiens_hsa053101.09756548
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.08060225
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06010216
61Hematopoietic cell lineage_Homo sapiens_hsa046401.05357592
62Collecting duct acid secretion_Homo sapiens_hsa049661.01428290
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01061028
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.00534271
65Circadian rhythm_Homo sapiens_hsa047101.00071992
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95974570
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94135015
68Ovarian steroidogenesis_Homo sapiens_hsa049130.92892459
69Primary immunodeficiency_Homo sapiens_hsa053400.81941359
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81299983
71Malaria_Homo sapiens_hsa051440.81141947
72African trypanosomiasis_Homo sapiens_hsa051430.81130248
73GABAergic synapse_Homo sapiens_hsa047270.79920288
74Vitamin digestion and absorption_Homo sapiens_hsa049770.79387814
75Other glycan degradation_Homo sapiens_hsa005110.79323602
76Mineral absorption_Homo sapiens_hsa049780.78054741
77Starch and sucrose metabolism_Homo sapiens_hsa005000.76762956
78Purine metabolism_Homo sapiens_hsa002300.76446222
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75840480
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75633002
81Olfactory transduction_Homo sapiens_hsa047400.74969957
82Calcium signaling pathway_Homo sapiens_hsa040200.73922422
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73216627
84Hedgehog signaling pathway_Homo sapiens_hsa043400.66877701
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66576510
86Nucleotide excision repair_Homo sapiens_hsa034200.65052367
87Pyrimidine metabolism_Homo sapiens_hsa002400.63940975
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.63803497
89Circadian entrainment_Homo sapiens_hsa047130.63576297
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.63239071
91Phagosome_Homo sapiens_hsa041450.62445998
92Basal cell carcinoma_Homo sapiens_hsa052170.62071315
93Type I diabetes mellitus_Homo sapiens_hsa049400.61974339
94Salivary secretion_Homo sapiens_hsa049700.60616870
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.57741956
96Cocaine addiction_Homo sapiens_hsa050300.56151011
97Butanoate metabolism_Homo sapiens_hsa006500.55726049
98Histidine metabolism_Homo sapiens_hsa003400.55715710
99Tryptophan metabolism_Homo sapiens_hsa003800.54801145
100Nitrogen metabolism_Homo sapiens_hsa009100.53680873
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53585631
102RNA degradation_Homo sapiens_hsa030180.52923072
103Wnt signaling pathway_Homo sapiens_hsa043100.52453036
104Choline metabolism in cancer_Homo sapiens_hsa052310.52429155
105Ras signaling pathway_Homo sapiens_hsa040140.51795940
106Long-term depression_Homo sapiens_hsa047300.51241804
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49065482
108Cardiac muscle contraction_Homo sapiens_hsa042600.48282806
109Renin secretion_Homo sapiens_hsa049240.47069576
110Measles_Homo sapiens_hsa051620.45960817
111Mismatch repair_Homo sapiens_hsa034300.44956353
112Regulation of autophagy_Homo sapiens_hsa041400.44406533
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.43712776
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43071395
115Proteasome_Homo sapiens_hsa030500.42321499
116cAMP signaling pathway_Homo sapiens_hsa040240.40442185
117Cholinergic synapse_Homo sapiens_hsa047250.39954309
118Hepatitis C_Homo sapiens_hsa051600.39714227
119Vibrio cholerae infection_Homo sapiens_hsa051100.39145616
120Sulfur metabolism_Homo sapiens_hsa009200.38447347
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38446184
122Alcoholism_Homo sapiens_hsa050340.38391017
123Notch signaling pathway_Homo sapiens_hsa043300.38292953
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.38103108
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.37569254
126Amphetamine addiction_Homo sapiens_hsa050310.37420571
127Vitamin B6 metabolism_Homo sapiens_hsa007500.37048640
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36236128
129Glycerolipid metabolism_Homo sapiens_hsa005610.34514706
130Systemic lupus erythematosus_Homo sapiens_hsa053220.33275692
131Chemokine signaling pathway_Homo sapiens_hsa040620.33126673
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32710969
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30803319
134Retinol metabolism_Homo sapiens_hsa008300.30573118
135Metabolic pathways_Homo sapiens_hsa011000.29346311
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.29316909
137Fatty acid biosynthesis_Homo sapiens_hsa000610.29265557
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.28784989
139PPAR signaling pathway_Homo sapiens_hsa033200.27998656
140Pertussis_Homo sapiens_hsa051330.27887284
141Arginine and proline metabolism_Homo sapiens_hsa003300.25354676
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.24656628
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24501567
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22447545
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.20423266
146Hippo signaling pathway_Homo sapiens_hsa043900.19943314
147Complement and coagulation cascades_Homo sapiens_hsa046100.18818530
148Adherens junction_Homo sapiens_hsa045200.17479911
149Lysosome_Homo sapiens_hsa041420.16686641
150N-Glycan biosynthesis_Homo sapiens_hsa005100.14453638
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13326140
152Pancreatic secretion_Homo sapiens_hsa049720.12420359
153Propanoate metabolism_Homo sapiens_hsa006400.11228450

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