CCDC115

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder OF glycosylation, type IIo in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.78551695
2ribosomal small subunit assembly (GO:0000028)4.76926000
3DNA strand elongation involved in DNA replication (GO:0006271)4.36683389
4Arp2/3 complex-mediated actin nucleation (GO:0034314)4.27212833
5telomere maintenance via semi-conservative replication (GO:0032201)4.21909497
6immunoglobulin mediated immune response (GO:0016064)4.21518608
7DNA strand elongation (GO:0022616)4.18215082
8DNA replication checkpoint (GO:0000076)4.06941865
9maturation of SSU-rRNA (GO:0030490)3.95112952
10proteasome assembly (GO:0043248)3.88914540
11positive regulation of B cell differentiation (GO:0045579)3.87029318
12telomere maintenance via recombination (GO:0000722)3.85906606
13nucleobase biosynthetic process (GO:0046112)3.83960358
14viral transcription (GO:0019083)3.83003864
15translational termination (GO:0006415)3.81054860
16mitotic metaphase plate congression (GO:0007080)3.77089419
17DNA replication initiation (GO:0006270)3.76529208
18purine nucleobase biosynthetic process (GO:0009113)3.72299806
19CENP-A containing nucleosome assembly (GO:0034080)3.69724018
20positive regulation of gamma-delta T cell activation (GO:0046645)3.69506629
21purine deoxyribonucleotide catabolic process (GO:0009155)3.63999799
22formation of translation preinitiation complex (GO:0001731)3.62565047
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58280136
24ribosomal small subunit biogenesis (GO:0042274)3.57977074
25mitotic recombination (GO:0006312)3.54194669
26actin nucleation (GO:0045010)3.52269197
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51530293
28chromatin remodeling at centromere (GO:0031055)3.50632673
29translational elongation (GO:0006414)3.48961758
30iron-sulfur cluster assembly (GO:0016226)3.45140598
31metallo-sulfur cluster assembly (GO:0031163)3.45140598
32DNA replication-independent nucleosome assembly (GO:0006336)3.44476918
33DNA replication-independent nucleosome organization (GO:0034724)3.44476918
34telomere maintenance via telomere lengthening (GO:0010833)3.42791814
35cotranslational protein targeting to membrane (GO:0006613)3.42755709
36attachment of spindle microtubules to kinetochore (GO:0008608)3.42694826
37translational initiation (GO:0006413)3.42117160
38regulation of B cell receptor signaling pathway (GO:0050855)3.40612461
39protein targeting to ER (GO:0045047)3.39581420
40B cell mediated immunity (GO:0019724)3.37221653
41sequestering of actin monomers (GO:0042989)3.37067447
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34644761
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34056745
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32871335
45metaphase plate congression (GO:0051310)3.32821645
46ribonucleoprotein complex biogenesis (GO:0022613)3.32349373
47ribosome biogenesis (GO:0042254)3.32348859
48DNA unwinding involved in DNA replication (GO:0006268)3.32044840
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29743130
50response to interferon-beta (GO:0035456)3.29402670
51neutrophil activation involved in immune response (GO:0002283)3.28334807
52protein localization to kinetochore (GO:0034501)3.26212362
53protein localization to endoplasmic reticulum (GO:0070972)3.25666360
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24505684
55ribosome assembly (GO:0042255)3.24415692
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23075047
57rRNA processing (GO:0006364)3.22424776
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22202392
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21848343
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21751005
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20242262
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.19650726
63pseudouridine synthesis (GO:0001522)3.18857909
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18789309
65ribosomal large subunit biogenesis (GO:0042273)3.16710283
66rRNA modification (GO:0000154)3.16141236
67establishment of chromosome localization (GO:0051303)3.16074459
68mitotic nuclear envelope disassembly (GO:0007077)3.14840369
69purine deoxyribonucleotide metabolic process (GO:0009151)3.12551602
70rRNA metabolic process (GO:0016072)3.09624027
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09502578
72cellular response to interferon-beta (GO:0035458)3.09054090
73protein localization to chromosome, centromeric region (GO:0071459)3.07856033
74spliceosomal snRNP assembly (GO:0000387)3.07329218
75antigen processing and presentation of endogenous antigen (GO:0019883)3.07082990
76negative regulation of cell killing (GO:0031342)3.05741237
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05741237
78DNA replication-dependent nucleosome organization (GO:0034723)3.04053203
79DNA replication-dependent nucleosome assembly (GO:0006335)3.04053203
80viral life cycle (GO:0019058)3.03496463
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.02037531
82termination of RNA polymerase III transcription (GO:0006386)3.02037531
83negative regulation of ligase activity (GO:0051352)3.01538190
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01538190
85purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.01185351
867-methylguanosine mRNA capping (GO:0006370)3.00596524
87deoxyribonucleotide catabolic process (GO:0009264)3.00098437
88regulation of B cell differentiation (GO:0045577)3.00067605
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99068645
90maturation of 5.8S rRNA (GO:0000460)2.97783515
91RNA capping (GO:0036260)2.97432584
927-methylguanosine RNA capping (GO:0009452)2.97432584
93cellular protein complex disassembly (GO:0043624)2.96759355
94transcription-coupled nucleotide-excision repair (GO:0006283)2.95481600
95IMP biosynthetic process (GO:0006188)2.94380226
96translation (GO:0006412)2.94175550
97regulation of spindle organization (GO:0090224)2.94129599
98kinetochore organization (GO:0051383)2.92945964
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.91800658
100mitotic chromosome condensation (GO:0007076)2.91477455
101energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90831789
102ATP hydrolysis coupled proton transport (GO:0015991)2.90831789
103IMP metabolic process (GO:0046040)2.90357368
104positive regulation of antigen processing and presentation (GO:0002579)2.90060734
105histone exchange (GO:0043486)2.89989256
106mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88155175
107nuclear envelope disassembly (GO:0051081)2.87279584
108membrane disassembly (GO:0030397)2.87279584
109kinetochore assembly (GO:0051382)2.86445408
110chaperone mediated protein folding requiring cofactor (GO:0051085)2.85520584
111ATP synthesis coupled proton transport (GO:0015986)2.82965279
112energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82965279
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82254296
114regulation of antigen processing and presentation (GO:0002577)2.80512116
115antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80489828
116negative T cell selection (GO:0043383)2.80055366
117NIK/NF-kappaB signaling (GO:0038061)2.79248560
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79077850
119cell cycle G1/S phase transition (GO:0044843)2.78840745
120G1/S transition of mitotic cell cycle (GO:0000082)2.78840745
121folic acid-containing compound biosynthetic process (GO:0009396)2.78720080
122respiratory burst (GO:0045730)2.78312939
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77854574
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77854574
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76743035
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76743035
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76743035
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76562354
129somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76562354
130isotype switching (GO:0045190)2.76562354
131negative thymic T cell selection (GO:0045060)2.76477531
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76363754
133deoxyribose phosphate catabolic process (GO:0046386)2.76156259
134negative regulation of telomere maintenance (GO:0032205)2.74325128
135autophagic vacuole fusion (GO:0000046)2.73943977
136nuclear-transcribed mRNA catabolic process (GO:0000956)2.73937236
137protein deneddylation (GO:0000338)2.72351592
138positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71475181
139positive thymic T cell selection (GO:0045059)2.71188507
140cellular component biogenesis (GO:0044085)2.70859209
141positive regulation of ligase activity (GO:0051351)2.70579890
1422-deoxyribonucleotide metabolic process (GO:0009394)2.67293765
143cytidine metabolic process (GO:0046087)2.65050207
144cytidine catabolic process (GO:0006216)2.65050207
145cytidine deamination (GO:0009972)2.65050207
146negative regulation of B cell apoptotic process (GO:0002903)2.64937376
147base-excision repair, AP site formation (GO:0006285)2.63689277
148deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.61550076
149positive regulation of T cell cytokine production (GO:0002726)2.59351030
150regulation of mast cell activation (GO:0033003)2.55253023
151interferon-gamma-mediated signaling pathway (GO:0060333)2.53417575
152Peyers patch development (GO:0048541)2.52501584
153mucosal-associated lymphoid tissue development (GO:0048537)2.52501584
154neutrophil activation (GO:0042119)2.51432562
155mast cell activation (GO:0045576)2.49653925
156pyrimidine nucleotide catabolic process (GO:0006244)2.48732012
157regulation of gamma-delta T cell differentiation (GO:0045586)2.47953737
158regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.47567381
159regulation of gamma-delta T cell activation (GO:0046643)2.47430555
160regulation of T cell tolerance induction (GO:0002664)2.44827769
161regulation of alpha-beta T cell proliferation (GO:0046640)2.44252731
162pyrimidine ribonucleoside catabolic process (GO:0046133)2.43526696
163deoxyribose phosphate metabolic process (GO:0019692)2.43023126
164regulation of T cell receptor signaling pathway (GO:0050856)2.40618208
165leukocyte degranulation (GO:0043299)2.40456620
166positive regulation of alpha-beta T cell proliferation (GO:0046641)2.38473815
167regulation of mast cell degranulation (GO:0043304)2.37906772
168granulocyte activation (GO:0036230)2.36793785
169organelle membrane fusion (GO:0090174)2.36125581
170antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35573251
171positive regulation of type 2 immune response (GO:0002830)2.35026135
172negative regulation of myeloid cell apoptotic process (GO:0033033)2.34172997
173cytochrome complex assembly (GO:0017004)2.34122393
174respiratory electron transport chain (GO:0022904)2.33482044
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33480672
176antigen receptor-mediated signaling pathway (GO:0050851)2.33348738
177detection of bacterium (GO:0016045)2.33325808
178mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33195043
179regulation of mast cell activation involved in immune response (GO:0033006)2.32755016
180negative regulation of mast cell activation (GO:0033004)2.31743917
181positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.30704252
182electron transport chain (GO:0022900)2.29406040
183respiratory chain complex IV assembly (GO:0008535)2.29264927
184positive regulation of mast cell activation (GO:0033005)2.28190053
185cullin deneddylation (GO:0010388)2.27586659
186T cell migration (GO:0072678)2.26367385
187positive regulation of interleukin-1 beta secretion (GO:0050718)2.25311120
188positive T cell selection (GO:0043368)2.25085884
189myeloid cell activation involved in immune response (GO:0002275)2.24465311
190type I interferon signaling pathway (GO:0060337)2.24033134
191cellular response to type I interferon (GO:0071357)2.24033134
192T cell costimulation (GO:0031295)2.23874962
193regulation of B cell apoptotic process (GO:0002902)2.21001826
194positive regulation of mast cell activation involved in immune response (GO:0033008)2.20508582
195positive regulation of mast cell degranulation (GO:0043306)2.20508582
196T cell receptor signaling pathway (GO:0050852)2.20373915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.78129104
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.96710450
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72458645
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48731292
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.32133205
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17838719
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.10350512
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06240681
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.03790955
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.99700214
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80279574
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76656903
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59319277
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58534004
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55012051
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53651630
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.49630597
18* VDR_23849224_ChIP-Seq_CD4+_Human2.48584885
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42983841
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42772481
21* XRN2_22483619_ChIP-Seq_HELA_Human2.25993144
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14110445
23FOXP3_21729870_ChIP-Seq_TREG_Human2.09390265
24* GABP_19822575_ChIP-Seq_HepG2_Human2.08723436
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08013971
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04600333
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03975987
28DCP1A_22483619_ChIP-Seq_HELA_Human2.02368708
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.01421857
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00641103
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98228694
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97063212
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96285286
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95334592
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.92878734
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92474374
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92434272
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86782382
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86257419
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82574583
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.81048078
42CIITA_25753668_ChIP-Seq_RAJI_Human1.80614925
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80095801
44* TTF2_22483619_ChIP-Seq_HELA_Human1.78869017
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78119500
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78069686
47BCL6_27268052_Chip-Seq_Bcells_Human1.77536832
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.73872188
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72951427
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69589007
51MYC_22102868_ChIP-Seq_BL_Human1.68999174
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67884194
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66539869
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65079540
55AR_21909140_ChIP-Seq_LNCAP_Human1.64894220
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.64352321
57ZNF274_21170338_ChIP-Seq_K562_Hela1.63936337
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63350831
59ELK1_19687146_ChIP-ChIP_HELA_Human1.61576701
60SPI1_23547873_ChIP-Seq_NB4_Human1.59880558
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.59315427
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55063064
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51944384
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51550916
65* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51291861
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48180090
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47691498
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.46024137
69UTX_26944678_Chip-Seq_JUKART_Human1.45706423
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40646547
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40522416
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40053502
73* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39592146
74KDM5A_27292631_Chip-Seq_BREAST_Human1.37941717
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36798170
76VDR_21846776_ChIP-Seq_THP-1_Human1.35036702
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33039261
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32571378
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.26511114
80* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26330884
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24536978
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24502632
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24350229
84BCOR_27268052_Chip-Seq_Bcells_Human1.24047770
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23976122
86GATA3_27048872_Chip-Seq_THYMUS_Human1.22937168
87* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22830894
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21645925
89TFEB_21752829_ChIP-Seq_HELA_Human1.20999019
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.20751964
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.20684413
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20088410
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19497146
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18262228
95CTCF_20526341_ChIP-Seq_ESCs_Human1.17796449
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.16933109
97MAF_26560356_Chip-Seq_TH2_Human1.16703431
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.16238317
99MAF_26560356_Chip-Seq_TH1_Human1.15801850
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15083439
101RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14478117
102* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13971305
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13246205
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11616447
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11014238
106P300_27268052_Chip-Seq_Bcells_Human1.07993654
107GATA3_26560356_Chip-Seq_TH2_Human1.07182956
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06666048
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06183471
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05256809
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05107169
112SCL_19346495_ChIP-Seq_HPC-7_Human1.03320257
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00976011
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99570040
115STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97936476
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97924604
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97822690
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.97602400
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.97499764
120MYC_18940864_ChIP-ChIP_HL60_Human0.97270009
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97044587
122TP53_22573176_ChIP-Seq_HFKS_Human0.96982600
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96968577
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96756024
125CTCF_26484167_Chip-Seq_Bcells_Mouse0.96495309
126* SPI1_23127762_ChIP-Seq_K562_Human0.95341456
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94740725
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94544116
129E2F1_20622854_ChIP-Seq_HELA_Human0.93954395
130RUNX_20019798_ChIP-Seq_JUKART_Human0.93873108
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93669642
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92726054
133STAT1_20625510_ChIP-Seq_HELA_Human0.92676637
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.92389854
135PHF8_20622854_ChIP-Seq_HELA_Human0.92268830
136MYB_26560356_Chip-Seq_TH2_Human0.91817817
137* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91333466
138* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87515169
139* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86506582
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86004233
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85928741
142MYB_26560356_Chip-Seq_TH1_Human0.83534592
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83320175
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83100237
145* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82555211
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82489844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.57028033
2MP0010094_abnormal_chromosome_stability3.94350955
3MP0003111_abnormal_nucleus_morphology3.85945101
4MP0004957_abnormal_blastocyst_morpholog3.83395408
5MP0003077_abnormal_cell_cycle3.57461805
6MP0008058_abnormal_DNA_repair3.05354929
7MP0008057_abnormal_DNA_replication2.99929855
8MP0002396_abnormal_hematopoietic_system2.94105997
9MP0008007_abnormal_cellular_replicative2.69399188
10MP0001835_abnormal_antigen_presentation2.51499565
11MP0000490_abnormal_crypts_of2.22128022
12MP0009333_abnormal_splenocyte_physiolog2.16583502
13MP0003763_abnormal_thymus_physiology2.16120275
14MP0008932_abnormal_embryonic_tissue2.11924191
15MP0002822_catalepsy1.95015071
16MP0003718_maternal_effect1.92708354
17MP0005671_abnormal_response_to1.91786718
18MP0003806_abnormal_nucleotide_metabolis1.91604609
19MP0002398_abnormal_bone_marrow1.90126463
20MP0005397_hematopoietic_system_phenotyp1.85054797
21MP0001545_abnormal_hematopoietic_system1.85054797
22MP0004808_abnormal_hematopoietic_stem1.84151148
23MP0003786_premature_aging1.82348973
24MP0003303_peritoneal_inflammation1.75999781
25MP0009764_decreased_sensitivity_to1.72295981
26MP0000689_abnormal_spleen_morphology1.71033708
27MP0000685_abnormal_immune_system1.70390031
28MP0009785_altered_susceptibility_to1.69945990
29MP0002722_abnormal_immune_system1.67571865
30MP0000350_abnormal_cell_proliferation1.62313637
31MP0003436_decreased_susceptibility_to1.62200697
32MP0002019_abnormal_tumor_incidence1.61715579
33MP0002420_abnormal_adaptive_immunity1.60976699
34MP0002452_abnormal_antigen_presenting1.59185562
35MP0001730_embryonic_growth_arrest1.59119616
36MP0001800_abnormal_humoral_immune1.59027400
37MP0001819_abnormal_immune_cell1.58822039
38MP0000465_gastrointestinal_hemorrhage1.55943281
39MP0000716_abnormal_immune_system1.55359752
40MP0005000_abnormal_immune_tolerance1.54270200
41MP0002429_abnormal_blood_cell1.54033013
42MP0002723_abnormal_immune_serum1.52451703
43MP0005025_abnormal_response_to1.51511565
44MP0005464_abnormal_platelet_physiology1.48711354
45MP0006292_abnormal_olfactory_placode1.47832871
46MP0008995_early_reproductive_senescence1.46694645
47MP0000313_abnormal_cell_death1.46336464
48MP0000703_abnormal_thymus_morphology1.42429816
49MP0003075_altered_response_to1.39816512
50MP0002653_abnormal_ependyma_morphology1.39126596
51MP0010307_abnormal_tumor_latency1.37724726
52MP0002419_abnormal_innate_immunity1.36509975
53MP0008877_abnormal_DNA_methylation1.34205014
54MP0000604_amyloidosis1.34168577
55MP0003123_paternal_imprinting1.32605525
56MP0003656_abnormal_erythrocyte_physiolo1.30026112
57MP0002405_respiratory_system_inflammati1.29675282
58MP0001529_abnormal_vocalization1.27669707
59MP0006276_abnormal_autonomic_nervous1.27447976
60MP0001905_abnormal_dopamine_level1.26756210
61MP0003880_abnormal_central_pattern1.26234547
62MP0001853_heart_inflammation1.25864150
63MP0001968_abnormal_touch/_nociception1.25641121
64MP0002138_abnormal_hepatobiliary_system1.25610483
65MP0005075_abnormal_melanosome_morpholog1.25338604
66MP0004147_increased_porphyrin_level1.23763967
67MP0002148_abnormal_hypersensitivity_rea1.22754992
68MP0009278_abnormal_bone_marrow1.21818851
69MP0001533_abnormal_skeleton_physiology1.21264292
70MP0002277_abnormal_respiratory_mucosa1.18620066
71MP0003186_abnormal_redox_activity1.17033768
72MP0001501_abnormal_sleep_pattern1.14928354
73MP0001697_abnormal_embryo_size1.14566809
74MP0000858_altered_metastatic_potential1.13844623
75MP0001984_abnormal_olfaction1.13273816
76MP0002166_altered_tumor_susceptibility1.12799063
77MP0002736_abnormal_nociception_after1.12169314
78MP0002006_tumorigenesis1.11405663
79MP0002080_prenatal_lethality1.10218676
80MP0003221_abnormal_cardiomyocyte_apopto1.09997372
81MP0002733_abnormal_thermal_nociception1.07596178
82MP0002638_abnormal_pupillary_reflex1.07161293
83MP0004859_abnormal_synaptic_plasticity1.06211269
84MP0009765_abnormal_xenobiotic_induced1.02578096
85MP0005646_abnormal_pituitary_gland1.02302068
86MP0002735_abnormal_chemical_nociception1.02021946
87MP0002132_abnormal_respiratory_system1.01849360
88MP0003191_abnormal_cellular_cholesterol1.00852859
89MP0003567_abnormal_fetal_cardiomyocyte1.00719893
90MP0006036_abnormal_mitochondrial_physio1.00547641
91MP0008875_abnormal_xenobiotic_pharmacok1.00444626
92MP0009046_muscle_twitch0.99312798
93MP0005535_abnormal_body_temperature0.98312236
94MP0000358_abnormal_cell_content/0.98264920
95MP0005394_taste/olfaction_phenotype0.98048924
96MP0005499_abnormal_olfactory_system0.98048924
97MP0001845_abnormal_inflammatory_respons0.97778202
98MP0003329_amyloid_beta_deposits0.97547315
99MP0005645_abnormal_hypothalamus_physiol0.96514149
100MP0005380_embryogenesis_phenotype0.96235271
101MP0001672_abnormal_embryogenesis/_devel0.96235271
102MP0005174_abnormal_tail_pigmentation0.96051141
103MP0005084_abnormal_gallbladder_morpholo0.95535375
104MP0010155_abnormal_intestine_physiology0.95244668
105MP0009763_increased_sensitivity_to0.94580232
106MP0008260_abnormal_autophagy0.94309307
107MP0002210_abnormal_sex_determination0.94204030
108MP0009745_abnormal_behavioral_response0.93837264
109MP0005451_abnormal_body_composition0.93268446
110MP0004947_skin_inflammation0.93220733
111MP0001790_abnormal_immune_system0.92936197
112MP0005387_immune_system_phenotype0.92936197
113MP0005360_urolithiasis0.92808472
114MP0002064_seizures0.92322707
115MP0003866_abnormal_defecation0.90663536
116MP0002095_abnormal_skin_pigmentation0.90574054
117MP0005551_abnormal_eye_electrophysiolog0.88925753
118MP0001119_abnormal_female_reproductive0.88648359
119MP0010352_gastrointestinal_tract_polyps0.88623242
120MP0001970_abnormal_pain_threshold0.88593663
121MP0003787_abnormal_imprinting0.88565746
122MP0001873_stomach_inflammation0.86852891
123MP0003984_embryonic_growth_retardation0.86767886
124MP0003690_abnormal_glial_cell0.86506803
125MP0005310_abnormal_salivary_gland0.86226995
126MP0001929_abnormal_gametogenesis0.84159893
127MP0002088_abnormal_embryonic_growth/wei0.83689853
128MP0003646_muscle_fatigue0.83415238
129MP0008874_decreased_physiological_sensi0.83346456
130MP0001145_abnormal_male_reproductive0.82223171
131MP0006035_abnormal_mitochondrial_morpho0.81795936
132MP0003724_increased_susceptibility_to0.81604118
133MP0009840_abnormal_foam_cell0.80989769
134MP0001764_abnormal_homeostasis0.80830299
135MP0005058_abnormal_lysosome_morphology0.80517003
136MP0008469_abnormal_protein_level0.79847379
137MP0000653_abnormal_sex_gland0.79039504
138MP0006082_CNS_inflammation0.78787526
139MP0002102_abnormal_ear_morphology0.78006765
140MP0005423_abnormal_somatic_nervous0.75486196
141MP0003011_delayed_dark_adaptation0.75240099
142MP0008789_abnormal_olfactory_epithelium0.74999277
143MP0005410_abnormal_fertilization0.74886053
144MP0003183_abnormal_peptide_metabolism0.73214240
145MP0000343_altered_response_to0.72642495
146MP0003172_abnormal_lysosome_physiology0.72567473
147MP0006054_spinal_hemorrhage0.71850507
148MP0005384_cellular_phenotype0.71836447
149MP0001986_abnormal_taste_sensitivity0.71723008
150MP0003315_abnormal_perineum_morphology0.70331511

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.66705300
2Abnormality of cells of the erythroid lineage (HP:0012130)4.48250156
3Abnormal number of erythroid precursors (HP:0012131)4.44796420
4Birth length less than 3rd percentile (HP:0003561)4.36481842
5Reticulocytopenia (HP:0001896)4.04857363
6Oral leukoplakia (HP:0002745)3.60847100
7IgM deficiency (HP:0002850)3.51958952
8Thrombocytosis (HP:0001894)3.36328634
9Degeneration of anterior horn cells (HP:0002398)3.31891263
10Abnormality of the anterior horn cell (HP:0006802)3.31891263
11Stomatitis (HP:0010280)3.22265073
12Recurrent abscess formation (HP:0002722)3.15329784
13Mitochondrial inheritance (HP:0001427)3.09798090
14Petechiae (HP:0000967)2.99442388
15Increased intramyocellular lipid droplets (HP:0012240)2.99333590
16Abnormal mitochondria in muscle tissue (HP:0008316)2.88459970
17Increased muscle lipid content (HP:0009058)2.87484547
18Mediastinal lymphadenopathy (HP:0100721)2.87075275
19Pallor (HP:0000980)2.85991736
20Amyotrophic lateral sclerosis (HP:0007354)2.85765672
21Rough bone trabeculation (HP:0100670)2.81965910
22Carpal bone hypoplasia (HP:0001498)2.80047757
23Breast hypoplasia (HP:0003187)2.79978133
24Chromsome breakage (HP:0040012)2.79353418
253-Methylglutaconic aciduria (HP:0003535)2.77279411
26Panhypogammaglobulinemia (HP:0003139)2.77070023
27Microretrognathia (HP:0000308)2.76887157
28Agnosia (HP:0010524)2.73274584
29Irregular epiphyses (HP:0010582)2.70876049
30Myelodysplasia (HP:0002863)2.69430803
31Acute necrotizing encephalopathy (HP:0006965)2.68732628
32Increased CSF lactate (HP:0002490)2.67420461
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64905305
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64905305
35Type I transferrin isoform profile (HP:0003642)2.63933751
36Recurrent bacterial skin infections (HP:0005406)2.60962638
37Macrocytic anemia (HP:0001972)2.59568740
38Mutism (HP:0002300)2.59160460
39Polyphagia (HP:0002591)2.58726771
40Encephalitis (HP:0002383)2.52274120
41Exertional dyspnea (HP:0002875)2.49911210
42Abnormality of chromosome stability (HP:0003220)2.49819927
43Bone marrow hypocellularity (HP:0005528)2.49206759
44Abnormality of the preputium (HP:0100587)2.47069438
45Increased IgM level (HP:0003496)2.45825561
46Cerebral hypomyelination (HP:0006808)2.43691203
47Reduced antithrombin III activity (HP:0001976)2.43265973
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42765990
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41631823
50Dicarboxylic aciduria (HP:0003215)2.41631823
51Type 2 muscle fiber atrophy (HP:0003554)2.39697914
52Emotional lability (HP:0000712)2.39537826
53Colon cancer (HP:0003003)2.39531224
54Muscle fiber atrophy (HP:0100295)2.39372438
55Patellar aplasia (HP:0006443)2.38821455
5611 pairs of ribs (HP:0000878)2.38236464
57Abnormality of liposaccharide metabolism (HP:0010968)2.37805548
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.37805548
59Abnormality of glycolipid metabolism (HP:0010969)2.37805548
60Retinal dysplasia (HP:0007973)2.37702586
61IgG deficiency (HP:0004315)2.36698170
62Recurrent fungal infections (HP:0002841)2.34955188
63Abnormality of alanine metabolism (HP:0010916)2.32802908
64Hyperalaninemia (HP:0003348)2.32802908
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32802908
66Severe combined immunodeficiency (HP:0004430)2.32661810
67Acute encephalopathy (HP:0006846)2.32482604
68Lymphoma (HP:0002665)2.32081897
69Meningitis (HP:0001287)2.31436046
70Progressive macrocephaly (HP:0004481)2.30823300
71Premature graying of hair (HP:0002216)2.30233524
72Pulmonary fibrosis (HP:0002206)2.29689564
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.29499717
74Retrobulbar optic neuritis (HP:0100654)2.27916788
75Optic neuritis (HP:0100653)2.27916788
76Agammaglobulinemia (HP:0004432)2.27280122
77Entropion (HP:0000621)2.26903238
78Increased hepatocellular lipid droplets (HP:0006565)2.25485523
79Abnormality of T cell physiology (HP:0011840)2.24792997
80Poor head control (HP:0002421)2.24417764
81Aplasia/Hypoplasia of the patella (HP:0006498)2.24206983
82Pancytopenia (HP:0001876)2.23690634
83Orchitis (HP:0100796)2.23540154
84Elevated erythrocyte sedimentation rate (HP:0003565)2.20922001
85Meckel diverticulum (HP:0002245)2.18696428
86Microvesicular hepatic steatosis (HP:0001414)2.18008565
87Loss of speech (HP:0002371)2.17829693
88Renal Fanconi syndrome (HP:0001994)2.17731466
89Multiple enchondromatosis (HP:0005701)2.17566403
90Lactic acidosis (HP:0003128)2.17303585
91Abolished electroretinogram (ERG) (HP:0000550)2.17242927
92Abnormality of the prostate (HP:0008775)2.16735079
93Chronic obstructive pulmonary disease (HP:0006510)2.16099802
94Obstructive lung disease (HP:0006536)2.16099802
95Chronic otitis media (HP:0000389)2.15214577
96Abnormal glycosylation (HP:0012345)2.15045451
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15045451
98Abnormal protein N-linked glycosylation (HP:0012347)2.15045451
99Abnormal protein glycosylation (HP:0012346)2.15045451
100Abnormality of the ileum (HP:0001549)2.15003400
101Lipid accumulation in hepatocytes (HP:0006561)2.12933751
102Atrophy/Degeneration involving motor neurons (HP:0007373)2.12902597
103Increased serum lactate (HP:0002151)2.11823008
104Severe visual impairment (HP:0001141)2.11596313
105Vacuolated lymphocytes (HP:0001922)2.09942924
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.09854890
107Prolonged bleeding time (HP:0003010)2.09385813
108Recurrent skin infections (HP:0001581)2.08659061
109Absent thumb (HP:0009777)2.08310298
110Generalized aminoaciduria (HP:0002909)2.07974757
111Poikiloderma (HP:0001029)2.07872998
112Recurrent cutaneous fungal infections (HP:0011370)2.07522992
113Chronic mucocutaneous candidiasis (HP:0002728)2.07522992
114Myositis (HP:0100614)2.07033078
115Hepatocellular necrosis (HP:0001404)2.06245941
116Abnormal trabecular bone morphology (HP:0100671)2.06078456
117Eczematoid dermatitis (HP:0000976)2.05995982
118Delusions (HP:0000746)2.05480257
119Cellular immunodeficiency (HP:0005374)2.05288575
120Increased cerebral lipofuscin (HP:0011813)2.04763845
121Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04371407
122Premature ovarian failure (HP:0008209)2.03958405
123Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00194425
124Amaurosis fugax (HP:0100576)1.96498362
125Granulocytopenia (HP:0001913)1.96408189
126Progressive microcephaly (HP:0000253)1.96227945
127Abnormality of DNA repair (HP:0003254)1.94932939
128Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94125862
129Urticaria (HP:0001025)1.93926827
130Eosinophilia (HP:0001880)1.92106506
131Slender long bone (HP:0003100)1.91288340
132Combined immunodeficiency (HP:0005387)1.91003598
133Secondary amenorrhea (HP:0000869)1.90808682
134Recurrent gram-negative bacterial infections (HP:0005420)1.90370218
135Recurrent bronchitis (HP:0002837)1.89887800
136Abnormality of T cells (HP:0002843)1.88907298
137Abnormal spermatogenesis (HP:0008669)1.88417233
138Hypergammaglobulinemia (HP:0010702)1.87857411
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87181622
140Duodenal stenosis (HP:0100867)1.86877595
141Small intestinal stenosis (HP:0012848)1.86877595
142Abnormality of B cell number (HP:0010975)1.86652739
143B lymphocytopenia (HP:0010976)1.86652739
144CNS hypomyelination (HP:0003429)1.85045092
145Stomach cancer (HP:0012126)1.84729512
146Hepatosplenomegaly (HP:0001433)1.84649382
147Hepatic necrosis (HP:0002605)1.84178079
148Flat capital femoral epiphysis (HP:0003370)1.84048228
149Vasculitis (HP:0002633)1.83851148
150Keratoconjunctivitis sicca (HP:0001097)1.83289885
151Pulmonary infiltrates (HP:0002113)1.83014664
152Abnormal delayed hypersensitivity skin test (HP:0002963)1.82447307
153Cerebral palsy (HP:0100021)1.82208708
154Selective tooth agenesis (HP:0001592)1.82080734
155Keratoconjunctivitis (HP:0001096)1.81688890
156Abnormality of macrophages (HP:0004311)1.81166156
157Increased neuronal autofluorescent lipopigment (HP:0002074)1.81018152
158Purpura (HP:0000979)1.80719941
159Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80603352
160Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80298526
161Recurrent viral infections (HP:0004429)1.79933519
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79561496
163CNS demyelination (HP:0007305)1.79236111
164Acute myeloid leukemia (HP:0004808)1.79148296
165T lymphocytopenia (HP:0005403)1.79126746
166Peripheral hypomyelination (HP:0007182)1.77841235
167Episodic fever (HP:0001954)1.77725519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.82706016
2STK163.92518688
3BCKDK3.49036317
4MAP4K23.44503811
5EIF2AK13.42791284
6WEE13.14067843
7NME22.76002597
8CDC72.68095867
9ACVR1B2.59109333
10MAP4K12.44268474
11VRK12.42650843
12NEK22.30732152
13RIPK42.26873723
14EIF2AK32.21201935
15PLK42.19443001
16FES1.98515197
17TESK21.98199576
18DYRK31.82383151
19PIM21.70977653
20SRPK11.62652402
21RPS6KA41.60919783
22TSSK61.60137081
23BRSK21.56350418
24IRAK41.53439102
25PLK11.51867146
26TTK1.49290951
27CCNB11.42892752
28CDK81.42233746
29ZAP701.40141496
30KIT1.38927418
31TEC1.37879337
32MAP2K71.35802635
33AURKB1.32997544
34SIK31.29351402
35MAP3K121.29004718
36VRK21.28193114
37CDK71.25851243
38TNK21.23563260
39BLK1.21374750
40ATR1.20901987
41TRIM281.20244450
42LIMK11.20049684
43TXK1.18603492
44KDR1.17105916
45BTK1.16731050
46BMPR21.16063377
47MAP3K111.15829023
48STK101.13473358
49MAP3K41.11033832
50CSNK1G31.09898823
51BRAF1.09374704
52RPS6KB21.08819687
53ITK1.08693933
54ERN11.08583150
55CHEK21.07440901
56NEK11.07374900
57PLK31.06729881
58PASK1.01279239
59SIK21.00637920
60SCYL21.00320912
61MAPK130.98667824
62FLT30.97674861
63DYRK1B0.97614768
64DAPK20.96907377
65CDK40.96882812
66AURKA0.96557794
67MAP3K60.96454410
68CSNK1G20.96020903
69EPHA30.95772450
70MAP3K80.94590505
71PAK40.91328891
72PIM10.90446267
73JAK30.89535789
74GRK70.89525569
75BCR0.88072617
76BRSK10.87742686
77MATK0.87131888
78CSK0.86806617
79TLK10.86448287
80BMPR1B0.85365944
81CSF1R0.84803919
82ARAF0.84181280
83RAF10.83436316
84MAPKAPK30.83428085
85GRK50.83372921
86FGR0.80929931
87MKNK10.80626606
88EEF2K0.80155793
89CSNK1A1L0.79759359
90MUSK0.79298300
91TAOK30.78870005
92LRRK20.78768837
93CAMKK20.78741163
94MAP2K30.78587284
95SYK0.78289833
96TYK20.78006369
97TBK10.77864386
98PINK10.77619144
99EIF2AK20.76571847
100TGFBR10.76008498
101PRKCQ0.71438775
102MARK10.71048596
103MAP2K60.67544598
104HCK0.66300092
105TAOK10.65717768
106CHEK10.65233677
107ADRBK20.64251325
108MAP2K40.64027658
109LYN0.63374484
110STK40.61621355
111IRAK30.61440321
112JAK20.61024869
113GRK10.60904274
114WNK30.60402119
115DYRK20.58128700
116TESK10.56728380
117CSNK2A10.56289158
118PAK10.54635284
119DYRK1A0.54102686
120CDK140.53123824
121ILK0.52673639
122CSNK1G10.52250152
123FYN0.50621310
124CSNK2A20.50332763
125STK240.49163580
126EPHB10.48330243
127TAOK20.48118060
128MAP3K50.47848744
129MINK10.47815587
130RPS6KA50.47518406
131NLK0.47267487
132ZAK0.46463967
133IKBKB0.45945550
134MOS0.45862580
135MAP3K140.45410552
136LCK0.44908585
137IKBKE0.43888500
138CDK20.42880868
139ERBB30.42586461
140CDK180.42152497
141MAP3K100.41582564
142ATM0.41360708
143ABL20.41175965
144CAMKK10.40932580
145CDK50.40923052
146DAPK10.40711592
147CDK11A0.40648774
148MST40.39561912
149CLK10.39378006
150CDK150.38936467
151MKNK20.38250549
152GRK60.38249310
153CDK190.37619773
154ABL10.36918350

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61712424
2Ribosome_Homo sapiens_hsa030103.72975235
3Mismatch repair_Homo sapiens_hsa034303.69512910
4Proteasome_Homo sapiens_hsa030503.53121712
5RNA polymerase_Homo sapiens_hsa030203.47406285
6Autoimmune thyroid disease_Homo sapiens_hsa053203.23231889
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17855275
8Base excision repair_Homo sapiens_hsa034103.12840247
9Homologous recombination_Homo sapiens_hsa034402.83720039
10Type I diabetes mellitus_Homo sapiens_hsa049402.81063718
11Spliceosome_Homo sapiens_hsa030402.79788160
12Nucleotide excision repair_Homo sapiens_hsa034202.64741940
13Pyrimidine metabolism_Homo sapiens_hsa002402.63209202
14RNA transport_Homo sapiens_hsa030132.59956992
15Cell cycle_Homo sapiens_hsa041102.33876645
16Rheumatoid arthritis_Homo sapiens_hsa053232.17393609
17Staphylococcus aureus infection_Homo sapiens_hsa051502.13434017
18Basal transcription factors_Homo sapiens_hsa030222.07960865
19RNA degradation_Homo sapiens_hsa030182.00587400
20Non-homologous end-joining_Homo sapiens_hsa034501.94662855
21Fanconi anemia pathway_Homo sapiens_hsa034601.90594350
22Collecting duct acid secretion_Homo sapiens_hsa049661.80893132
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77748867
24Viral myocarditis_Homo sapiens_hsa054161.75998201
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66802132
26One carbon pool by folate_Homo sapiens_hsa006701.63311070
27Protein export_Homo sapiens_hsa030601.59216018
28Alzheimers disease_Homo sapiens_hsa050101.49457961
29Folate biosynthesis_Homo sapiens_hsa007901.48790481
30Purine metabolism_Homo sapiens_hsa002301.47943266
31Phototransduction_Homo sapiens_hsa047441.33177061
32Fatty acid elongation_Homo sapiens_hsa000621.31117780
33p53 signaling pathway_Homo sapiens_hsa041151.26898821
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23636377
35Primary immunodeficiency_Homo sapiens_hsa053401.21342988
36Epstein-Barr virus infection_Homo sapiens_hsa051691.21212440
37Antigen processing and presentation_Homo sapiens_hsa046121.21000138
38Synaptic vesicle cycle_Homo sapiens_hsa047211.20302471
39Pentose phosphate pathway_Homo sapiens_hsa000301.17473463
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09993203
41mRNA surveillance pathway_Homo sapiens_hsa030151.07922276
42Other glycan degradation_Homo sapiens_hsa005111.04062842
43Herpes simplex infection_Homo sapiens_hsa051681.01264615
44Peroxisome_Homo sapiens_hsa041460.99442073
45Legionellosis_Homo sapiens_hsa051340.97874008
46Salmonella infection_Homo sapiens_hsa051320.94470838
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91976349
48N-Glycan biosynthesis_Homo sapiens_hsa005100.91000466
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90524222
50Vitamin B6 metabolism_Homo sapiens_hsa007500.86876408
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86427782
52Sulfur relay system_Homo sapiens_hsa041220.84631438
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80369958
54Hematopoietic cell lineage_Homo sapiens_hsa046400.77789703
55Measles_Homo sapiens_hsa051620.75875819
56Leishmaniasis_Homo sapiens_hsa051400.75378244
57Sulfur metabolism_Homo sapiens_hsa009200.75230381
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.74549006
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.74306030
60Parkinsons disease_Homo sapiens_hsa050120.73392072
61Regulation of autophagy_Homo sapiens_hsa041400.73268313
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70035543
63Nicotine addiction_Homo sapiens_hsa050330.70022748
64Ether lipid metabolism_Homo sapiens_hsa005650.69517733
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69171990
66Shigellosis_Homo sapiens_hsa051310.67973867
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.67139108
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66806406
69Viral carcinogenesis_Homo sapiens_hsa052030.66184898
70Huntingtons disease_Homo sapiens_hsa050160.66083881
71Oocyte meiosis_Homo sapiens_hsa041140.64639298
72Vibrio cholerae infection_Homo sapiens_hsa051100.63651203
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62388576
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.62297290
75Systemic lupus erythematosus_Homo sapiens_hsa053220.61561632
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61516732
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61225226
78Apoptosis_Homo sapiens_hsa042100.59955927
79Galactose metabolism_Homo sapiens_hsa000520.59543995
80Cardiac muscle contraction_Homo sapiens_hsa042600.59417279
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59036567
82Oxidative phosphorylation_Homo sapiens_hsa001900.57392131
83HTLV-I infection_Homo sapiens_hsa051660.55637493
84Arachidonic acid metabolism_Homo sapiens_hsa005900.55630711
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54631799
86Asthma_Homo sapiens_hsa053100.54038980
87Toxoplasmosis_Homo sapiens_hsa051450.53411438
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53127173
89Biosynthesis of amino acids_Homo sapiens_hsa012300.52039374
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.51834865
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51280847
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50614091
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50596939
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50203123
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49538704
96Fructose and mannose metabolism_Homo sapiens_hsa000510.48147975
97Hepatitis B_Homo sapiens_hsa051610.47290321
98Malaria_Homo sapiens_hsa051440.47243416
99B cell receptor signaling pathway_Homo sapiens_hsa046620.46398963
100Allograft rejection_Homo sapiens_hsa053300.45968041
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45737761
102GABAergic synapse_Homo sapiens_hsa047270.44935092
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44879826
104Selenocompound metabolism_Homo sapiens_hsa004500.44562768
105Chemokine signaling pathway_Homo sapiens_hsa040620.44402833
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44024532
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42279350
108Linoleic acid metabolism_Homo sapiens_hsa005910.41221727
109Thyroid cancer_Homo sapiens_hsa052160.41103330
110Influenza A_Homo sapiens_hsa051640.40599904
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40493624
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39927794
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39547092
114Lysosome_Homo sapiens_hsa041420.39054068
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38162638
116Glutathione metabolism_Homo sapiens_hsa004800.36125944
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.34933252
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33034337
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32805133
120Butanoate metabolism_Homo sapiens_hsa006500.32798683
121Acute myeloid leukemia_Homo sapiens_hsa052210.29909183
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28979408
123Metabolic pathways_Homo sapiens_hsa011000.28756754
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28721622
125Endocytosis_Homo sapiens_hsa041440.28133128
126Colorectal cancer_Homo sapiens_hsa052100.27941507
127Morphine addiction_Homo sapiens_hsa050320.27104513
128Tuberculosis_Homo sapiens_hsa051520.27005107
129Pancreatic cancer_Homo sapiens_hsa052120.25602541
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23322727
131Pertussis_Homo sapiens_hsa051330.22958457
132Olfactory transduction_Homo sapiens_hsa047400.22032040
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.21811255
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21405901
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21075496
136Phagosome_Homo sapiens_hsa041450.20938380
137T cell receptor signaling pathway_Homo sapiens_hsa046600.20169552
138Carbon metabolism_Homo sapiens_hsa012000.20045358
139Osteoclast differentiation_Homo sapiens_hsa043800.18581011
140Graft-versus-host disease_Homo sapiens_hsa053320.18430686
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17779880
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15756135

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