CCDC116

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.84521213
2axonemal dynein complex assembly (GO:0070286)9.33843132
3cilium or flagellum-dependent cell motility (GO:0001539)9.15055580
4acrosome assembly (GO:0001675)9.09763184
5multicellular organism reproduction (GO:0032504)9.03615902
6sperm-egg recognition (GO:0035036)8.98704198
7motile cilium assembly (GO:0044458)8.97646080
8epithelial cilium movement (GO:0003351)8.58910455
9binding of sperm to zona pellucida (GO:0007339)8.05297223
10cell-cell recognition (GO:0009988)8.01321667
11spermatid development (GO:0007286)7.96600403
12plasma membrane fusion (GO:0045026)7.83095400
13regulation of cilium movement (GO:0003352)7.50501556
14reproduction (GO:0000003)7.37034877
15negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.35613791
16cilium movement (GO:0003341)7.23628916
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.78570422
18piRNA metabolic process (GO:0034587)6.76179503
19microtubule depolymerization (GO:0007019)6.51618930
20rRNA methylation (GO:0031167)6.40086141
21single fertilization (GO:0007338)6.19860951
22sexual reproduction (GO:0019953)6.12852265
23regulation of retinoic acid receptor signaling pathway (GO:0048385)5.92946079
24male meiosis (GO:0007140)5.91648144
25sperm capacitation (GO:0048240)5.83529699
26response to pheromone (GO:0019236)5.80815791
27spermatogenesis (GO:0007283)5.46103092
28male gamete generation (GO:0048232)5.44773296
29rRNA modification (GO:0000154)5.37340555
30phosphatidylethanolamine biosynthetic process (GO:0006646)5.35081754
31synaptonemal complex organization (GO:0070193)5.30337851
32phosphatidylethanolamine metabolic process (GO:0046337)5.17712418
33fertilization (GO:0009566)5.12398988
34male meiosis I (GO:0007141)5.08405315
35gamete generation (GO:0007276)5.05657353
36synaptonemal complex assembly (GO:0007130)5.05593155
37DNA methylation involved in gamete generation (GO:0043046)4.93075352
38organic cation transport (GO:0015695)4.76631377
39ventricular system development (GO:0021591)4.75941534
40nuclear pore organization (GO:0006999)4.73663795
41negative regulation of inclusion body assembly (GO:0090084)4.70428845
42chromatin silencing (GO:0006342)4.70273177
43germ cell development (GO:0007281)4.61733616
44chromosome organization involved in meiosis (GO:0070192)4.54157635
45regulation of histone H3-K27 methylation (GO:0061085)4.53091175
46cellular ketone body metabolic process (GO:0046950)4.44041094
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.42971812
48DNA conformation change (GO:0071103)4.35588055
49protein-DNA complex disassembly (GO:0032986)4.27624015
50nucleosome disassembly (GO:0006337)4.27624015
51pore complex assembly (GO:0046931)4.26680792
52calcium ion-dependent exocytosis (GO:0017156)4.19720626
53negative regulation of histone methylation (GO:0031061)4.11960053
54synapsis (GO:0007129)4.04755372
55mitotic nuclear envelope disassembly (GO:0007077)4.04656700
56spermatid nucleus differentiation (GO:0007289)4.03187755
57cell recognition (GO:0008037)4.01969309
58protein targeting to Golgi (GO:0000042)4.01094630
59regulation of centriole replication (GO:0046599)3.98911068
60membrane disassembly (GO:0030397)3.97775663
61nuclear envelope disassembly (GO:0051081)3.97775663
62multicellular organismal reproductive process (GO:0048609)3.94845464
63meiosis I (GO:0007127)3.93656426
64ketone body metabolic process (GO:1902224)3.85338134
65peptidyl-threonine dephosphorylation (GO:0035970)3.79197993
66regulation of microtubule-based movement (GO:0060632)3.78961440
67meiotic cell cycle (GO:0051321)3.77221833
68single strand break repair (GO:0000012)3.76991544
69establishment of protein localization to Golgi (GO:0072600)3.76375066
70histone H3-K9 demethylation (GO:0033169)3.76189687
71regulation of inclusion body assembly (GO:0090083)3.72158213
72meiotic nuclear division (GO:0007126)3.65627270
73retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64047604
74DNA replication checkpoint (GO:0000076)3.63200012
75centriole assembly (GO:0098534)3.61878137
76DNA packaging (GO:0006323)3.61427562
77GTP biosynthetic process (GO:0006183)3.61122171
78regulation of Rab GTPase activity (GO:0032313)3.51155105
79positive regulation of Rab GTPase activity (GO:0032851)3.51155105
80chromosome condensation (GO:0030261)3.45271778
81microtubule severing (GO:0051013)3.43112215
82left/right pattern formation (GO:0060972)3.40098568
83negative regulation of gene expression, epigenetic (GO:0045814)3.39181419
84microtubule polymerization or depolymerization (GO:0031109)3.38053107
85protein depolymerization (GO:0051261)3.37655947
86RNA destabilization (GO:0050779)3.34771299
87regulation of translational fidelity (GO:0006450)3.34694101
88protein localization to cilium (GO:0061512)3.28761202
89response to vitamin A (GO:0033189)3.27388414
90protein K11-linked deubiquitination (GO:0035871)3.25668931
91seminiferous tubule development (GO:0072520)3.24344460
92centriole replication (GO:0007099)3.21749219
93multicellular organismal development (GO:0007275)3.20241515
94interferon-gamma secretion (GO:0072643)3.18823799
95nucleoside diphosphate phosphorylation (GO:0006165)3.15192073
96UTP biosynthetic process (GO:0006228)3.14388850
97cilium organization (GO:0044782)3.11578567
98glycerol ether metabolic process (GO:0006662)3.11570122
99intraciliary transport (GO:0042073)3.08159486
100homeostasis of number of cells within a tissue (GO:0048873)3.07825852
101cilium assembly (GO:0042384)3.07611775
102regulation of transcription involved in cell fate commitment (GO:0060850)3.05576442
103regulation of spindle checkpoint (GO:0090231)3.02649799
104response to acidic pH (GO:0010447)3.01866848
105chaperone-mediated protein complex assembly (GO:0051131)3.01267101
106mitotic sister chromatid segregation (GO:0000070)2.98656866
107genitalia morphogenesis (GO:0035112)2.96387548
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95779473
109gas transport (GO:0015669)2.93968731
110DNA replication initiation (GO:0006270)2.91790849
111detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.90942424
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89612847
113protein localization to Golgi apparatus (GO:0034067)2.87314526
114ether metabolic process (GO:0018904)2.86688425
115microtubule nucleation (GO:0007020)2.86415749
116regulation of histone H3-K4 methylation (GO:0051569)2.84242892
117face development (GO:0060324)2.81580841
118sister chromatid segregation (GO:0000819)2.80906690
119nuclear envelope organization (GO:0006998)2.80698870
120DNA unwinding involved in DNA replication (GO:0006268)2.79783404
121mitotic chromosome condensation (GO:0007076)2.79195784
122meiotic cell cycle process (GO:1903046)2.78557660
123coenzyme catabolic process (GO:0009109)2.78467145
124misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.75218335
125axoneme assembly (GO:0035082)2.70806838
126cellular component assembly involved in morphogenesis (GO:0010927)2.70687664
127protein polyglutamylation (GO:0018095)2.70340277
128regulation of meiosis I (GO:0060631)2.69383286
129reciprocal meiotic recombination (GO:0007131)2.63025821
130reciprocal DNA recombination (GO:0035825)2.63025821
131cilium morphogenesis (GO:0060271)2.61286410
132nucleus organization (GO:0006997)2.61092426
133UTP metabolic process (GO:0046051)2.54921638
134mitotic sister chromatid cohesion (GO:0007064)2.52940810
135monoubiquitinated protein deubiquitination (GO:0035520)2.51355025
136left/right axis specification (GO:0070986)2.48801534
137polyol catabolic process (GO:0046174)2.48243865
138guanosine-containing compound biosynthetic process (GO:1901070)2.46105657
139DNA ligation (GO:0006266)2.44593336
140polyamine biosynthetic process (GO:0006596)2.35376149
141histone exchange (GO:0043486)2.35062672
142sister chromatid cohesion (GO:0007062)2.33826600
143negative regulation of skeletal muscle tissue development (GO:0048642)2.33358427
144nuclear pore complex assembly (GO:0051292)2.28243864
145alditol metabolic process (GO:0019400)2.27453206
146sequestering of actin monomers (GO:0042989)2.23525292
147RNA localization (GO:0006403)2.23254196
148pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.22350485
149response to X-ray (GO:0010165)2.21879007
150microtubule-based movement (GO:0007018)2.21790361
151sperm motility (GO:0030317)10.7324139
152fusion of sperm to egg plasma membrane (GO:0007342)10.4721702
153cell wall macromolecule catabolic process (GO:0016998)10.2208490
154cell wall macromolecule metabolic process (GO:0044036)10.2208490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.40763933
2E2F7_22180533_ChIP-Seq_HELA_Human5.94829075
3EZH2_22144423_ChIP-Seq_EOC_Human4.57781630
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.87519513
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.81634746
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.32380626
7PCGF2_27294783_Chip-Seq_ESCs_Mouse3.23970140
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.10939300
9VDR_22108803_ChIP-Seq_LS180_Human2.98921707
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80197223
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.77281906
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69941101
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.47948238
14ELF1_20517297_ChIP-Seq_JURKAT_Human2.47618281
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.43912124
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39703024
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.36668069
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32822524
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32037705
20GATA1_19941826_ChIP-Seq_K562_Human2.30400772
21* NCOR1_26117541_ChIP-Seq_K562_Human2.26982109
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11343456
23P68_20966046_ChIP-Seq_HELA_Human2.06501749
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06347132
25LXR_22292898_ChIP-Seq_THP-1_Human2.03095280
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00164833
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.98742566
28YY1_22570637_ChIP-Seq_MALME-3M_Human1.94356387
29RAC3_21632823_ChIP-Seq_H3396_Human1.91824248
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.90504375
31BCOR_27268052_Chip-Seq_Bcells_Human1.89657317
32E2F1_20622854_ChIP-Seq_HELA_Human1.87725825
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.87017719
34PHF8_20622854_ChIP-Seq_HELA_Human1.84515627
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.83430606
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79935457
37SMC4_20622854_ChIP-Seq_HELA_Human1.77522753
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.77475357
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.76844633
40P53_22387025_ChIP-Seq_ESCs_Mouse1.73350754
41TAF15_26573619_Chip-Seq_HEK293_Human1.72967050
42BCL6_27268052_Chip-Seq_Bcells_Human1.71791688
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.70535939
44RNF2_27304074_Chip-Seq_NSC_Mouse1.66320784
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66006689
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62235237
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.61850968
48EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61022203
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.61008850
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.60798858
51OCT4_18555785_Chip-Seq_ESCs_Mouse1.60467359
52RBPJ_21746931_ChIP-Seq_IB4_Human1.60101090
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59308659
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58025760
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.57449596
56ERA_21632823_ChIP-Seq_H3396_Human1.56789674
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.56753085
58P300_18555785_Chip-Seq_ESCs_Mouse1.56294688
59CTCF_27219007_Chip-Seq_Bcells_Human1.56035319
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55273403
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54814151
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54767554
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53345699
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53299130
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.52265811
66* CTCF_20526341_ChIP-Seq_ESCs_Human1.52174614
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52013687
68NANOG_20526341_ChIP-Seq_ESCs_Human1.51987315
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49765395
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.49286786
71STAT1_17558387_ChIP-Seq_HELA_Human1.47866476
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.47461694
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.47093432
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.46914851
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.46628153
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46127154
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45984355
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45984355
79ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45932960
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.45859844
81* MYC_18555785_ChIP-Seq_MESCs_Mouse1.45833517
82FUS_26573619_Chip-Seq_HEK293_Human1.45687668
83RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45047074
84PHF8_20622853_ChIP-Seq_HELA_Human1.44532996
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.44322436
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.43506556
87PU1_27457419_Chip-Seq_LIVER_Mouse1.42330535
88KDM2B_26808549_Chip-Seq_REH_Human1.41679999
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.40595323
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39695452
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.38194147
92GATA2_19941826_ChIP-Seq_K562_Human1.36611007
93CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36157351
94NFYB_21822215_ChIP-Seq_K562_Human1.34949037
95* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33757320
96KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33700782
97XRN2_22483619_ChIP-Seq_HELA_Human1.33432819
98SA1_27219007_Chip-Seq_Bcells_Human1.32695351
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.32550709
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.31005866
101OCT4_20526341_ChIP-Seq_ESCs_Human1.30755355
102P300_27268052_Chip-Seq_Bcells_Human1.30748526
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.29535217
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28945589
105IRF1_19129219_ChIP-ChIP_H3396_Human1.28406185
106CTCF_21964334_Chip-Seq_Bcells_Human1.27924661
107P53_21459846_ChIP-Seq_SAOS-2_Human1.26192855
108SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26077522
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25730281
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.24850273
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.24652246
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24563561
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24218265
114ZNF274_21170338_ChIP-Seq_K562_Hela1.24098776
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.24016277
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23845045
117TP63_22573176_ChIP-Seq_HFKS_Human1.23599758
118* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23252384
119GBX2_23144817_ChIP-Seq_PC3_Human1.22542525
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21678814
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20983710
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20670363
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.20623933
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19082691
125ER_23166858_ChIP-Seq_MCF-7_Human1.18505322
126TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18177680
127MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18038722
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16798981
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16752305
130TET1_21451524_ChIP-Seq_MESCs_Mouse1.16374844
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15908280
132GATA3_21867929_ChIP-Seq_CD8_Mouse1.15209982
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15186383
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15055696
135CBP_20019798_ChIP-Seq_JUKART_Human1.15055696
136KDM5A_27292631_Chip-Seq_BREAST_Human1.14771907
137JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14591750
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14196658
139TTF2_22483619_ChIP-Seq_HELA_Human1.14161268
140ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13713451
141WDR5_24793694_ChIP-Seq_LNCAP_Human1.13326761
142P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13288130
143FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12625774
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12080179
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11957060
146GF1_26923725_Chip-Seq_HPCs_Mouse1.11592146
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11446567
148* SPI1_23127762_ChIP-Seq_K562_Human1.11420683
149* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10886993
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10381184
151TAF2_19829295_ChIP-Seq_ESCs_Human1.09230594
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08413879
153GATA3_21867929_ChIP-Seq_TH1_Mouse1.08318205
154TBL1_22424771_ChIP-Seq_293T_Human1.07601219
155CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07507372
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06243042
157* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06223284
158REST_21632747_ChIP-Seq_MESCs_Mouse1.06089909
159PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05722732
160THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05495623
161ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05416504
162NFYA_21822215_ChIP-Seq_K562_Human1.04354986
163CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04082329
164STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03890379
165P300_19829295_ChIP-Seq_ESCs_Human0.99811174
166CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98962627
167RARA_24833708_ChIP-Seq_LIVER_Mouse0.97295125
168KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97067800
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96885205
170FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96413884
171SALL1_21062744_ChIP-ChIP_HESCs_Human0.95422471
172PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94690623
173MYC_22102868_ChIP-Seq_BL_Human0.93596580
174SMAD4_21799915_ChIP-Seq_A2780_Human0.93011267
175SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92583270
176SOX2_22085726_ChIP-Seq_NPCs_Mouse0.92120277
177LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91638649
178MYC_19829295_ChIP-Seq_ESCs_Human0.91297339
179E2F1_21310950_ChIP-Seq_MCF-7_Human0.91237080
180SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91159894
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90891215
182RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89939234
183SMAD3_21741376_ChIP-Seq_EPCs_Human0.89894499
184GF1B_26923725_Chip-Seq_HPCs_Mouse0.88965345
185SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88705789
186ETV1_20927104_ChIP-Seq_GIST48_Human0.88309362
187GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.87897497
188STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86465918
189TCF4_23295773_ChIP-Seq_U87_Human0.86138685
190SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84667509
191CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84638754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.45886659
2MP0001929_abnormal_gametogenesis4.06565999
3MP0000678_abnormal_parathyroid_gland3.58155579
4MP0005451_abnormal_body_composition3.46271901
5MP0001348_abnormal_lacrimal_gland3.29860310
6MP0008877_abnormal_DNA_methylation3.26757300
7MP0001188_hyperpigmentation2.93856830
8MP0002210_abnormal_sex_determination2.83172038
9MP0004957_abnormal_blastocyst_morpholog2.76169158
10MP0003136_yellow_coat_color2.72777723
11MP0005409_darkened_coat_color2.61787709
12MP0005377_hearing/vestibular/ear_phenot2.55691853
13MP0003878_abnormal_ear_physiology2.55691853
14MP0005174_abnormal_tail_pigmentation2.50548680
15MP0002160_abnormal_reproductive_system2.34621363
16MP0002161_abnormal_fertility/fecundity2.29603362
17MP0000015_abnormal_ear_pigmentation2.28314288
18MP0001145_abnormal_male_reproductive2.28156410
19MP0005083_abnormal_biliary_tract2.19123823
20MP0003077_abnormal_cell_cycle2.11245372
21MP0000653_abnormal_sex_gland2.01207601
22MP0001986_abnormal_taste_sensitivity2.00394499
23MP0005410_abnormal_fertilization11.4896167
24MP0008058_abnormal_DNA_repair1.92878146
25MP0002249_abnormal_larynx_morphology1.89954771
26MP0008057_abnormal_DNA_replication1.85346759
27MP0002102_abnormal_ear_morphology1.73142709
28MP0009697_abnormal_copulation1.71011420
29MP0004381_abnormal_hair_follicle1.56490391
30MP0009379_abnormal_foot_pigmentation1.54241418
31MP0008932_abnormal_embryonic_tissue1.50685377
32MP0002132_abnormal_respiratory_system1.47936499
33MP0010307_abnormal_tumor_latency1.44894932
34MP0005389_reproductive_system_phenotype1.38966868
35MP0006292_abnormal_olfactory_placode1.38824467
36MP0004233_abnormal_muscle_weight1.35615222
37MP0010094_abnormal_chromosome_stability1.33747216
38MP0003656_abnormal_erythrocyte_physiolo1.29655540
39MP0002009_preneoplasia1.29245745
40MP0005379_endocrine/exocrine_gland_phen1.28658945
41MP0002822_catalepsy1.27031643
42MP0001984_abnormal_olfaction1.26918664
43MP0003693_abnormal_embryo_hatching1.26888146
44MP0005670_abnormal_white_adipose1.26607403
45MP0005423_abnormal_somatic_nervous1.22682627
46MP0003787_abnormal_imprinting1.22545682
47MP0002095_abnormal_skin_pigmentation1.17154928
48MP0005645_abnormal_hypothalamus_physiol1.17001513
49MP0002163_abnormal_gland_morphology1.15533671
50MP0005075_abnormal_melanosome_morpholog1.13141581
51MP0002277_abnormal_respiratory_mucosa1.11986189
52MP0003941_abnormal_skin_development1.11558084
53MP0003699_abnormal_female_reproductive1.05458869
54MP0002282_abnormal_trachea_morphology1.01220667
55MP0009115_abnormal_fat_cell1.00700310
56MP0005395_other_phenotype1.00502551
57MP0001730_embryonic_growth_arrest1.00340239
58MP0003646_muscle_fatigue0.99923318
59MP0002080_prenatal_lethality0.99155533
60MP0001835_abnormal_antigen_presentation0.96556728
61MP0002148_abnormal_hypersensitivity_rea0.95584550
62MP0001873_stomach_inflammation0.94966926
63MP0005666_abnormal_adipose_tissue0.94738516
64MP0000313_abnormal_cell_death0.94445882
65MP0001672_abnormal_embryogenesis/_devel0.91801186
66MP0005380_embryogenesis_phenotype0.91801186
67MP0004742_abnormal_vestibular_system0.91666032
68MP0000350_abnormal_cell_proliferation0.90943348
69MP0009278_abnormal_bone_marrow0.90609471
70MP0003315_abnormal_perineum_morphology0.89645310
71MP0004147_increased_porphyrin_level0.89355610
72MP0000681_abnormal_thyroid_gland0.88711043
73MP0002234_abnormal_pharynx_morphology0.88623341
74MP0008995_early_reproductive_senescence0.87848177
75MP0002269_muscular_atrophy0.87614534
76MP0005636_abnormal_mineral_homeostasis0.87586194
77MP0000049_abnormal_middle_ear0.86743541
78MP0003111_abnormal_nucleus_morphology0.86599968
79MP0002638_abnormal_pupillary_reflex0.84172826
80MP0002736_abnormal_nociception_after0.82744284
81MP0000566_synostosis0.82612199
82MP0002653_abnormal_ependyma_morphology0.82429865
83MP0003786_premature_aging0.82422661
84MP0003763_abnormal_thymus_physiology0.82081897
85MP0002085_abnormal_embryonic_tissue0.80786608
86MP0008007_abnormal_cellular_replicative0.80426203
87MP0001919_abnormal_reproductive_system0.79647107
88MP0005310_abnormal_salivary_gland0.79384579
89MP0003942_abnormal_urinary_system0.79324419
90MP0001697_abnormal_embryo_size0.78546956
91MP0001119_abnormal_female_reproductive0.78208582
92MP0001968_abnormal_touch/_nociception0.77063223
93MP0000631_abnormal_neuroendocrine_gland0.76293704
94MP0005646_abnormal_pituitary_gland0.75971072
95MP0003880_abnormal_central_pattern0.75157876
96MP0005253_abnormal_eye_physiology0.74832338
97MP0005647_abnormal_sex_gland0.73601715
98MP0003123_paternal_imprinting0.73544125
99MP0001529_abnormal_vocalization0.72533889
100MP0005671_abnormal_response_to0.72417901
101MP0008770_decreased_survivor_rate0.72233027
102MP0009785_altered_susceptibility_to0.71052681
103MP0004145_abnormal_muscle_electrophysio0.71003107
104MP0000383_abnormal_hair_follicle0.69815962
105MP0002127_abnormal_cardiovascular_syste0.68934026
106MP0001765_abnormal_ion_homeostasis0.68908306
107MP0002177_abnormal_outer_ear0.68366820
108MP0003959_abnormal_lean_body0.68027316
109MP0006036_abnormal_mitochondrial_physio0.67517086
110MP0002405_respiratory_system_inflammati0.67018261
111MP0000490_abnormal_crypts_of0.66408530
112MP0002970_abnormal_white_adipose0.65828980
113MP0000534_abnormal_ureter_morphology0.65304858
114MP0000026_abnormal_inner_ear0.65293791
115MP0006035_abnormal_mitochondrial_morpho0.65048956
116MP0003011_delayed_dark_adaptation0.64451698
117MP0009046_muscle_twitch0.64425630
118MP0009250_abnormal_appendicular_skeleto0.63901472
119MP0006072_abnormal_retinal_apoptosis0.63312968
120MP0001545_abnormal_hematopoietic_system0.63035912
121MP0005397_hematopoietic_system_phenotyp0.63035912
122MP0001727_abnormal_embryo_implantation0.62833194
123MP0003984_embryonic_growth_retardation0.62371327
124MP0003724_increased_susceptibility_to0.61938924
125MP0005375_adipose_tissue_phenotype0.61929955
126MP0002938_white_spotting0.61091540
127MP0000647_abnormal_sebaceous_gland0.60337810
128MP0005623_abnormal_meninges_morphology0.60066011
129MP0005535_abnormal_body_temperature0.60025606
130MP0003385_abnormal_body_wall0.58798160
131MP0003119_abnormal_digestive_system0.58717102
132MP0006276_abnormal_autonomic_nervous0.57418874
133MP0005025_abnormal_response_to0.56555953
134MP0000569_abnormal_digit_pigmentation0.56514906
135MP0002086_abnormal_extraembryonic_tissu0.56473410
136MP0002723_abnormal_immune_serum0.56140176
137MP0009333_abnormal_splenocyte_physiolog0.55443844
138MP0002088_abnormal_embryonic_growth/wei0.55065461
139MP0005000_abnormal_immune_tolerance0.54572328
140MP0002876_abnormal_thyroid_physiology0.53620901
141MP0003938_abnormal_ear_development0.52355462
142MP0004808_abnormal_hematopoietic_stem0.51681912
143MP0002229_neurodegeneration0.51617009
144MP0003879_abnormal_hair_cell0.51435802
145MP0002084_abnormal_developmental_patter0.51182434
146MP0001800_abnormal_humoral_immune0.50494152
147MP0002420_abnormal_adaptive_immunity0.49982767
148MP0001819_abnormal_immune_cell0.49975346
149MP0002971_abnormal_brown_adipose0.49837126
150MP0004859_abnormal_synaptic_plasticity0.49598814
151MP0004085_abnormal_heartbeat0.48536372
152MP0005551_abnormal_eye_electrophysiolog0.47935698
153MP0004036_abnormal_muscle_relaxation0.47564110
154MP0008775_abnormal_heart_ventricle0.47536793
155MP0002557_abnormal_social/conspecific_i0.47370921
156MP0002452_abnormal_antigen_presenting0.47325117
157MP0001881_abnormal_mammary_gland0.46469356
158MP0001324_abnormal_eye_pigmentation0.46101670
159MP0002398_abnormal_bone_marrow0.45442248
160MP0000703_abnormal_thymus_morphology0.45366515
161MP0001790_abnormal_immune_system0.45135401
162MP0005387_immune_system_phenotype0.45135401
163MP0001661_extended_life_span0.45123796
164MP0005391_vision/eye_phenotype0.42699800
165MP0001963_abnormal_hearing_physiology0.42054041
166MP0001664_abnormal_digestion0.41806135
167MP0003718_maternal_effect0.41449877

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.03716410
2Abnormal respiratory motile cilium morphology (HP:0005938)8.03716410
3Abnormal respiratory motile cilium physiology (HP:0012261)7.88754467
4Abnormal ciliary motility (HP:0012262)6.72079825
5Rhinitis (HP:0012384)6.08048970
6Severe visual impairment (HP:0001141)5.85076078
7Cholecystitis (HP:0001082)5.44656195
8Abnormal gallbladder physiology (HP:0012438)5.44656195
9Nasal polyposis (HP:0100582)5.11276735
10Chronic bronchitis (HP:0004469)5.06492730
11Hyperthyroidism (HP:0000836)5.06334694
12Truncus arteriosus (HP:0001660)5.04389154
13Infertility (HP:0000789)4.85037197
14Reticulocytosis (HP:0001923)4.27896983
15Bony spicule pigmentary retinopathy (HP:0007737)4.11880638
16Bowel incontinence (HP:0002607)4.01297768
17Bronchiectasis (HP:0002110)3.93752722
18Aplasia/Hypoplasia of the earlobes (HP:0009906)3.91587485
19Abnormality of the nasal mucosa (HP:0000433)3.90831253
20Nephronophthisis (HP:0000090)3.88150351
21Unilateral renal agenesis (HP:0000122)3.84090424
22Abnormal large intestine physiology (HP:0012700)3.82197680
23Hypoparathyroidism (HP:0000829)3.78221842
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.64204168
25Seborrheic dermatitis (HP:0001051)3.58305969
26Bronchitis (HP:0012387)3.46270138
27Resting tremor (HP:0002322)3.44272812
28Cholelithiasis (HP:0001081)3.41194377
29Atelectasis (HP:0100750)3.34432838
30Upper limb muscle weakness (HP:0003484)3.31418693
31Recurrent sinusitis (HP:0011108)3.25081566
32Peripheral hypomyelination (HP:0007182)3.22510701
33Abnormality of reticulocytes (HP:0004312)3.20097644
34Polycythemia (HP:0001901)3.14122222
35Hyperkalemia (HP:0002153)3.13880403
36Abnormal gallbladder morphology (HP:0012437)3.12514023
37Hypertensive crisis (HP:0100735)3.11778895
38Bell-shaped thorax (HP:0001591)3.05056567
39Abnormality of the renal medulla (HP:0100957)3.04553181
40Spastic paraparesis (HP:0002313)2.98740482
41Obsessive-compulsive behavior (HP:0000722)2.96059237
42Abnormal spermatogenesis (HP:0008669)2.94443553
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91497582
44Aplasia/Hypoplasia of the thymus (HP:0010515)2.64138020
45Abnormality of midbrain morphology (HP:0002418)2.60917760
46Molar tooth sign on MRI (HP:0002419)2.60917760
47Abnormality of the gallbladder (HP:0005264)2.56699706
48Impulsivity (HP:0100710)2.56595443
49Abnormality of the tricuspid valve (HP:0001702)2.55903608
50Asymmetric septal hypertrophy (HP:0001670)2.55391847
51Chromsome breakage (HP:0040012)2.54018571
52Abnormality of macular pigmentation (HP:0008002)2.52462213
53Recurrent otitis media (HP:0000403)2.52248342
54Potter facies (HP:0002009)2.50737906
55Facial shape deformation (HP:0011334)2.50737906
56Ankyloglossia (HP:0010296)2.50417931
57Tubulointerstitial nephritis (HP:0001970)2.50214088
58Abnormality of the parathyroid morphology (HP:0011766)2.47078573
59Male infertility (HP:0003251)2.41979107
60Recurrent bronchitis (HP:0002837)2.39455077
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37362934
62Birth length less than 3rd percentile (HP:0003561)2.33840905
63Generalized aminoaciduria (HP:0002909)2.33304031
64Abnormality of dental color (HP:0011073)2.33214836
65Medial flaring of the eyebrow (HP:0010747)2.32313739
66Abnormal rod and cone electroretinograms (HP:0008323)2.30614362
67Ileus (HP:0002595)2.27868382
68Urethral obstruction (HP:0000796)2.26717433
69Recurrent corneal erosions (HP:0000495)2.25541578
70Optic neuritis (HP:0100653)2.23445249
71Retrobulbar optic neuritis (HP:0100654)2.23445249
72Termporal pattern (HP:0011008)2.22720419
73Insidious onset (HP:0003587)2.22720419
74Acute myeloid leukemia (HP:0004808)2.20916682
75Hypoalphalipoproteinemia (HP:0003233)2.19985453
76Renovascular hypertension (HP:0100817)2.19332026
77Abnormality of homocysteine metabolism (HP:0010919)2.18750662
78Homocystinuria (HP:0002156)2.18750662
79Progressive sensorineural hearing impairment (HP:0000408)2.16775435
80Sandal gap (HP:0001852)2.16619347
81Abnormality of the preputium (HP:0100587)2.15316340
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.14821384
83Progressive hearing impairment (HP:0001730)2.14557746
84Abnormally folded helix (HP:0008544)2.13204774
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.11625282
86Abnormality of cochlea (HP:0000375)2.08177381
87Poikilocytosis (HP:0004447)2.08148160
88Gonadotropin excess (HP:0000837)2.07763612
89Abnormality of glycolysis (HP:0004366)2.07761594
90Chronic sinusitis (HP:0011109)2.04556053
91True hermaphroditism (HP:0010459)2.04537894
92Decreased central vision (HP:0007663)2.02559242
93Patellar dislocation (HP:0002999)2.01554067
94Absent/shortened dynein arms (HP:0200106)11.1783649
95Dynein arm defect of respiratory motile cilia (HP:0012255)11.1783649
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7811075
97Underdeveloped nasal alae (HP:0000430)1.95054975
98Hypoplasia of the thymus (HP:0000778)1.94391788
99Meckel diverticulum (HP:0002245)1.93013582
100Azoospermia (HP:0000027)1.92003692
101Postaxial foot polydactyly (HP:0001830)1.90746289
102Clubbing of toes (HP:0100760)1.90583083
103Abnormality of the thymus (HP:0000777)1.90574093
104Abnormality of the heme biosynthetic pathway (HP:0010472)1.88954076
105Cone-rod dystrophy (HP:0000548)1.88895714
106Postural instability (HP:0002172)1.88381640
107Chronic hepatic failure (HP:0100626)1.88179977
108Truncal obesity (HP:0001956)1.87893295
109Cortical visual impairment (HP:0100704)1.86726742
110Dyschromatopsia (HP:0007641)1.86124210
111Congenital hepatic fibrosis (HP:0002612)1.84160244
112Abnormality of the ileum (HP:0001549)1.83877555
113Hypergonadotropic hypogonadism (HP:0000815)1.82995748
114Overfolded helix (HP:0000396)1.81466229
115Tubular atrophy (HP:0000092)1.80987074
116Median cleft lip (HP:0000161)1.79505102
117Abnormality of permanent molar morphology (HP:0011071)1.79449634
118Abnormality of the dental root (HP:0006486)1.79449634
119Taurodontia (HP:0000679)1.79449634
120Abnormality of the aortic arch (HP:0012303)1.76683119
121Ectopic kidney (HP:0000086)1.76474115
122Abnormality of molar morphology (HP:0011070)1.75404356
123Abnormality of molar (HP:0011077)1.75404356
124Increased serum pyruvate (HP:0003542)1.75186914
125Supernumerary spleens (HP:0009799)1.73973415
126Stridor (HP:0010307)1.73581881
127Short femoral neck (HP:0100864)1.71289926
128Enlarged epiphyses (HP:0010580)1.70954729
129Pancreatic fibrosis (HP:0100732)1.70683721
130Abnormality of the renal cortex (HP:0011035)1.70124379
131Abnormality of the dental pulp (HP:0006479)1.70007351
132Attenuation of retinal blood vessels (HP:0007843)1.67029763
133Stage 5 chronic kidney disease (HP:0003774)1.66951646
134Abnormality of chromosome stability (HP:0003220)1.65791587
135Fibular hypoplasia (HP:0003038)1.63363918
136Reticulocytopenia (HP:0001896)1.63161120
137Nephroblastoma (Wilms tumor) (HP:0002667)1.62712662
138Aplasia/Hypoplasia of the lens (HP:0008063)1.61678822
139Orchitis (HP:0100796)1.60177312
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57413310
141Optic nerve hypoplasia (HP:0000609)1.57252611
142Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.57113649
143Type 2 muscle fiber atrophy (HP:0003554)1.55330215
144Tubulointerstitial abnormality (HP:0001969)1.55224448
145Double outlet right ventricle (HP:0001719)1.55120418
146Congenital malformation of the right heart (HP:0011723)1.55120418
147Myositis (HP:0100614)1.53758390
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.52681013
149Short tibia (HP:0005736)1.52512688
150Preaxial hand polydactyly (HP:0001177)1.51576694
151Absent thumb (HP:0009777)1.50432437
152Constricted visual fields (HP:0001133)1.49894513
153Duplicated collecting system (HP:0000081)1.49687556
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.46825264
155Absent epiphyses (HP:0010577)1.46825264
156Embryonal renal neoplasm (HP:0011794)1.46605547
157Facial cleft (HP:0002006)1.45712029
158Renal dysplasia (HP:0000110)1.44033628
159Abnormality of the renal collecting system (HP:0004742)1.43035220
160Abnormal number of erythroid precursors (HP:0012131)1.42359195
161Male pseudohermaphroditism (HP:0000037)1.41679147
16211 pairs of ribs (HP:0000878)1.41665855
163Postaxial hand polydactyly (HP:0001162)1.41291386
164Abnormality of renal resorption (HP:0011038)1.41039943
165Microglossia (HP:0000171)1.39924683
166Absent eyebrow (HP:0002223)1.39729938
167Abnormal biliary tract physiology (HP:0012439)1.39550550
168Bile duct proliferation (HP:0001408)1.39550550
169Small intestinal stenosis (HP:0012848)1.39431914
170Duodenal stenosis (HP:0100867)1.39431914
171Abnormality of the carotid arteries (HP:0005344)1.36973647
172Absent rod-and cone-mediated responses on ERG (HP:0007688)1.36758438
173Choroideremia (HP:0001139)1.36396537
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.36165179
175Abnormality of DNA repair (HP:0003254)1.35585922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.97133743
2PDK45.97133743
3TESK14.45545447
4PDK24.02941504
5CASK3.26121284
6PRKD33.16681222
7CDK122.98090042
8KSR22.97408762
9BRD42.89243426
10DDR22.84027872
11ICK2.48930257
12EIF2AK12.36257652
13MAP3K22.33746414
14EEF2K2.19302661
15CLK12.09177519
16NTRK32.00668462
17MAP4K21.91562179
18PNCK1.77049760
19CAMK1G1.76887244
20NME11.75727398
21MAP3K81.74549491
22TXK1.67219634
23STK391.64251732
24BMPR1B1.63338775
25PTK2B1.60505481
26PLK21.60249016
27CDK71.60222103
28LATS21.56679927
29YES11.53544307
30WNK41.53218214
31STK161.40510794
32MUSK1.40085472
33DYRK31.36976229
34NUAK11.34446109
35PIK3CG1.32564910
36PLK41.32315504
37TNIK1.27127567
38ZAK1.23155823
39MST1R1.21979098
40MKNK21.21695166
41IRAK11.21568825
42NEK21.20139871
43PDPK11.19654498
44MAPK151.15121690
45ADRBK21.13620909
46DYRK1B1.13099007
47TSSK61.12513187
48BUB11.12398000
49EIF2AK21.07460811
50GRK71.07033728
51STK31.06057544
52GRK11.05344000
53IRAK41.04827560
54MAP3K11.04460030
55MAP3K141.03401891
56TEC1.02719953
57STK381.02378335
58CDK11.01676301
59CDK20.99774693
60CDK30.99755087
61VRK10.98945370
62PBK0.96417969
63PASK0.96114033
64RAF10.94862320
65IRAK30.89202603
66SIK30.88501310
67MTOR0.88387085
68RIPK40.88018486
69BRSK10.86750510
70CAMK1D0.86669926
71STK240.86220021
72BRSK20.83016471
73CDK40.82214652
74MST40.81278565
75NEK60.79089257
76NEK90.77314989
77MAP3K40.76357303
78CHEK20.75545171
79TTK0.75414735
80INSRR0.72111535
81GSK3B0.71019045
82PRKAA20.69897794
83MAP2K60.69538672
84PIM20.68264666
85PDK10.68014469
86SRPK10.65676261
87AKT30.63992458
88CCNB10.63664409
89ATR0.63468620
90RPS6KB10.62499191
91TRIB30.62391203
92MAPK100.61581578
93BMX0.60974204
94MAPK130.60201771
95NLK0.59958335
96PRPF4B0.59824690
97ROCK10.59736666
98MAP2K20.59517793
99BMPR20.58806927
100LATS10.57096224
101STK38L0.56384798
102BTK0.55661928
103PAK10.54968959
104MAPK140.54434173
105MKNK10.53608738
106SIK20.53221532
107WNK10.53054075
108PAK20.52091752
109CDC70.51457338
110RPS6KA10.49031761
111EIF2AK30.46551020
112IRAK20.46001361
113MAPK10.45975299
114PKN10.45399179
115ATM0.44337386
116ERBB30.44090012
117JAK30.43759644
118NTRK20.42483235
119MAP3K60.42233207
120MAP2K10.41918999
121AKT10.39895507
122TESK20.38890788
123PIM10.38680844
124STK40.38435789
125LYN0.38403126
126PLK30.38319519
127CHEK10.37892913
128UHMK10.35840909
129RET0.35573939
130MAPK80.35379844
131ITK0.35131077
132AURKA0.33825244
133TYRO30.33634624
134SYK0.33199774
135MAP3K70.32249274
136PRKAA10.32114229
137NEK10.31450024
138MAP2K70.31431740
139PRKCQ0.31395709
140CSNK2A10.31267165
141WEE10.30990031
142KSR10.30843077
143LCK0.30389653
144TRPM70.28741380
145FRK0.28646828
146RPS6KA20.27376252
147PRKG10.25521779
148HCK0.25032985
149BRAF0.24534912
150DYRK1A0.23125016
151SGK20.22837965
152MAP4K10.21995474
153DYRK20.21934521
154PLK10.21678781
155CSNK2A20.21337293
156IKBKB0.20609391
157KIT0.20512266
158PRKG20.20268171
159ZAP700.19277535
160FES0.18238707

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.93773251
2Fanconi anemia pathway_Homo sapiens_hsa034603.55913509
3Basal transcription factors_Homo sapiens_hsa030222.84112638
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.39947516
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30531209
6Linoleic acid metabolism_Homo sapiens_hsa005912.24491685
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13454674
8Type II diabetes mellitus_Homo sapiens_hsa049301.92281276
9Steroid biosynthesis_Homo sapiens_hsa001001.86833991
10Fatty acid biosynthesis_Homo sapiens_hsa000611.82138049
11Biosynthesis of amino acids_Homo sapiens_hsa012301.81339552
12Homologous recombination_Homo sapiens_hsa034401.79256663
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71312443
14Ribosome_Homo sapiens_hsa030101.62764610
15Ether lipid metabolism_Homo sapiens_hsa005651.57070003
16One carbon pool by folate_Homo sapiens_hsa006701.54442158
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52599604
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50524935
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49527249
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49050522
21Butanoate metabolism_Homo sapiens_hsa006501.48776604
22DNA replication_Homo sapiens_hsa030301.47449822
23Sphingolipid metabolism_Homo sapiens_hsa006001.46467490
24Purine metabolism_Homo sapiens_hsa002301.46112981
25Arachidonic acid metabolism_Homo sapiens_hsa005901.44512974
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38266311
27Fatty acid metabolism_Homo sapiens_hsa012121.37041966
28Huntingtons disease_Homo sapiens_hsa050161.34744804
29Other glycan degradation_Homo sapiens_hsa005111.32858155
30Pyrimidine metabolism_Homo sapiens_hsa002401.30556697
31Acute myeloid leukemia_Homo sapiens_hsa052211.29247983
32Mineral absorption_Homo sapiens_hsa049781.28656369
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26571521
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26501505
35Vitamin B6 metabolism_Homo sapiens_hsa007501.25591605
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25184784
37Taste transduction_Homo sapiens_hsa047421.24501181
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24197722
39Fructose and mannose metabolism_Homo sapiens_hsa000511.23616518
40Carbon metabolism_Homo sapiens_hsa012001.21955345
41Pyruvate metabolism_Homo sapiens_hsa006201.21176442
42Non-homologous end-joining_Homo sapiens_hsa034501.20332906
43mRNA surveillance pathway_Homo sapiens_hsa030151.20061550
44Dorso-ventral axis formation_Homo sapiens_hsa043201.19630411
45Renin secretion_Homo sapiens_hsa049241.19021999
46RNA transport_Homo sapiens_hsa030131.18968803
47Amphetamine addiction_Homo sapiens_hsa050311.18840489
48RNA degradation_Homo sapiens_hsa030181.18689816
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18290115
50Antigen processing and presentation_Homo sapiens_hsa046121.17043785
51Allograft rejection_Homo sapiens_hsa053301.13572480
52Phototransduction_Homo sapiens_hsa047441.11832951
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10238791
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09806456
55Mismatch repair_Homo sapiens_hsa034301.09656350
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.08794083
57Graft-versus-host disease_Homo sapiens_hsa053321.04928360
58RNA polymerase_Homo sapiens_hsa030201.04640669
59Autoimmune thyroid disease_Homo sapiens_hsa053201.02503812
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02462949
61Arginine biosynthesis_Homo sapiens_hsa002201.02223819
62Base excision repair_Homo sapiens_hsa034101.01393757
63Nicotine addiction_Homo sapiens_hsa050331.00913640
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.99481172
65Glucagon signaling pathway_Homo sapiens_hsa049220.97013369
66Measles_Homo sapiens_hsa051620.96483245
67Primary immunodeficiency_Homo sapiens_hsa053400.95547504
68Nucleotide excision repair_Homo sapiens_hsa034200.93332098
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93326623
70Arginine and proline metabolism_Homo sapiens_hsa003300.91405871
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.90481368
72Lysine degradation_Homo sapiens_hsa003100.89310265
73Calcium signaling pathway_Homo sapiens_hsa040200.88175335
74VEGF signaling pathway_Homo sapiens_hsa043700.86393503
75mTOR signaling pathway_Homo sapiens_hsa041500.86186418
76Hematopoietic cell lineage_Homo sapiens_hsa046400.83723697
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82159741
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81438497
79p53 signaling pathway_Homo sapiens_hsa041150.79119131
80Cardiac muscle contraction_Homo sapiens_hsa042600.75610419
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75391931
82Spliceosome_Homo sapiens_hsa030400.74701980
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74209826
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73932721
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71617912
86Cell cycle_Homo sapiens_hsa041100.71413903
87Vitamin digestion and absorption_Homo sapiens_hsa049770.71308484
88Oocyte meiosis_Homo sapiens_hsa041140.70909404
89Wnt signaling pathway_Homo sapiens_hsa043100.70774837
90Viral carcinogenesis_Homo sapiens_hsa052030.70559838
91Legionellosis_Homo sapiens_hsa051340.69837283
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67046494
93Protein export_Homo sapiens_hsa030600.64558243
94Selenocompound metabolism_Homo sapiens_hsa004500.64470991
95Herpes simplex infection_Homo sapiens_hsa051680.63738814
96Insulin signaling pathway_Homo sapiens_hsa049100.63683465
97Inositol phosphate metabolism_Homo sapiens_hsa005620.63288661
98T cell receptor signaling pathway_Homo sapiens_hsa046600.63247798
99Salivary secretion_Homo sapiens_hsa049700.62911747
100Hedgehog signaling pathway_Homo sapiens_hsa043400.62173548
101Insulin secretion_Homo sapiens_hsa049110.62145351
102Asthma_Homo sapiens_hsa053100.60562841
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58964117
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.58440556
105Serotonergic synapse_Homo sapiens_hsa047260.57570125
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57226586
107Glycerolipid metabolism_Homo sapiens_hsa005610.57200097
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.57121832
109Chronic myeloid leukemia_Homo sapiens_hsa052200.57088371
110Basal cell carcinoma_Homo sapiens_hsa052170.56039782
111Systemic lupus erythematosus_Homo sapiens_hsa053220.54578310
112Type I diabetes mellitus_Homo sapiens_hsa049400.53716190
113HIF-1 signaling pathway_Homo sapiens_hsa040660.53347085
114African trypanosomiasis_Homo sapiens_hsa051430.53106992
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51502455
116Endocytosis_Homo sapiens_hsa041440.51451715
117Rheumatoid arthritis_Homo sapiens_hsa053230.49256783
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49087508
119Long-term potentiation_Homo sapiens_hsa047200.48875552
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48519380
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48030414
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47966793
123Influenza A_Homo sapiens_hsa051640.46609070
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45777787
125Epstein-Barr virus infection_Homo sapiens_hsa051690.45423681
126Glutamatergic synapse_Homo sapiens_hsa047240.45343720
127Prolactin signaling pathway_Homo sapiens_hsa049170.44908093
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44695993
129ErbB signaling pathway_Homo sapiens_hsa040120.43794737
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43368582
131Estrogen signaling pathway_Homo sapiens_hsa049150.43327669
132Renin-angiotensin system_Homo sapiens_hsa046140.42529521
133Cocaine addiction_Homo sapiens_hsa050300.42407018
134Folate biosynthesis_Homo sapiens_hsa007900.42203458
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41874024
136Fatty acid degradation_Homo sapiens_hsa000710.40139777
137Olfactory transduction_Homo sapiens_hsa047400.39914799
138Alzheimers disease_Homo sapiens_hsa050100.39911305
139Salmonella infection_Homo sapiens_hsa051320.39333510
140cAMP signaling pathway_Homo sapiens_hsa040240.38920184
141Sulfur relay system_Homo sapiens_hsa041220.38791174
142B cell receptor signaling pathway_Homo sapiens_hsa046620.38651695
143Pancreatic secretion_Homo sapiens_hsa049720.38623339
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.38543584
145Oxidative phosphorylation_Homo sapiens_hsa001900.38486836
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.31991153
147AMPK signaling pathway_Homo sapiens_hsa041520.30874927
148Non-small cell lung cancer_Homo sapiens_hsa052230.30771765
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30736234
150Metabolic pathways_Homo sapiens_hsa011000.29896853
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25620622
152Phenylalanine metabolism_Homo sapiens_hsa003600.25360210
153MicroRNAs in cancer_Homo sapiens_hsa052060.23710279
154ABC transporters_Homo sapiens_hsa020100.17568838
155Glioma_Homo sapiens_hsa052140.16901018
156Thyroid cancer_Homo sapiens_hsa052160.16526460
157Renal cell carcinoma_Homo sapiens_hsa052110.15581622
158Fat digestion and absorption_Homo sapiens_hsa049750.14441604

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