CCDC120

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a coiled-coil domain. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1artery development (GO:0060840)5.77489890
2behavioral response to nicotine (GO:0035095)5.70172952
3vitamin transmembrane transport (GO:0035461)4.82217971
4establishment of apical/basal cell polarity (GO:0035089)4.77081872
5regulation of hippo signaling (GO:0035330)4.69565605
6determination of adult lifespan (GO:0008340)4.65906849
7morphogenesis of an epithelial fold (GO:0060571)4.61061771
8establishment of monopolar cell polarity (GO:0061162)4.56860163
9establishment or maintenance of monopolar cell polarity (GO:0061339)4.56860163
10desmosome organization (GO:0002934)4.51113552
11establishment of skin barrier (GO:0061436)4.49588998
12basic amino acid transport (GO:0015802)4.46538036
13paraxial mesoderm development (GO:0048339)4.37469634
14regulation of water loss via skin (GO:0033561)4.34334339
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.19934417
16polarized epithelial cell differentiation (GO:0030859)4.18432703
17keratinocyte development (GO:0003334)4.07303167
18regulation of early endosome to late endosome transport (GO:2000641)4.00553426
19hemidesmosome assembly (GO:0031581)3.97243177
20negative regulation of telomerase activity (GO:0051974)3.92484185
21histone H3-K4 trimethylation (GO:0080182)3.82526432
22intestinal epithelial cell development (GO:0060576)3.82438397
23pyrimidine nucleobase catabolic process (GO:0006208)3.78473617
24DNA damage induced protein phosphorylation (GO:0006975)3.75080253
25notochord development (GO:0030903)3.71610111
26regulation of gene silencing by RNA (GO:0060966)3.68043434
27regulation of posttranscriptional gene silencing (GO:0060147)3.68043434
28regulation of gene silencing by miRNA (GO:0060964)3.68043434
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.55100248
30establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.39624969
31layer formation in cerebral cortex (GO:0021819)3.38766554
32response to pheromone (GO:0019236)3.34935440
33hippo signaling (GO:0035329)3.34806902
34DNA methylation involved in gamete generation (GO:0043046)3.30623299
35adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.28916738
36cell migration in hindbrain (GO:0021535)3.26320741
37keratinization (GO:0031424)3.24384942
38pyrimidine-containing compound transmembrane transport (GO:0072531)3.22884888
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21856212
40pre-miRNA processing (GO:0031054)3.21435990
41piRNA metabolic process (GO:0034587)3.15765374
42multicellular organismal water homeostasis (GO:0050891)3.15182034
43embryonic camera-type eye development (GO:0031076)3.12217571
44cardiac right ventricle morphogenesis (GO:0003215)3.11867069
45pattern specification involved in kidney development (GO:0061004)3.09096631
46cornea development in camera-type eye (GO:0061303)3.05172904
47nucleobase catabolic process (GO:0046113)3.03307802
48positive regulation of synapse maturation (GO:0090129)3.01457999
49lateral sprouting from an epithelium (GO:0060601)3.00911299
50trophectodermal cell differentiation (GO:0001829)3.00539196
51peptidyl-tyrosine autophosphorylation (GO:0038083)2.95538716
52preassembly of GPI anchor in ER membrane (GO:0016254)2.95114020
53peptidyl-arginine omega-N-methylation (GO:0035247)2.93689480
54negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.91532610
55regulation of nuclear cell cycle DNA replication (GO:0033262)2.91080181
56nephron tubule morphogenesis (GO:0072078)2.90880430
57nephron epithelium morphogenesis (GO:0072088)2.90880430
58regulation of glycogen (starch) synthase activity (GO:2000465)2.90782082
59histone arginine methylation (GO:0034969)2.90606450
60nodal signaling pathway (GO:0038092)2.88258072
61intracellular estrogen receptor signaling pathway (GO:0030520)2.88183011
62negative regulation of microtubule polymerization (GO:0031115)2.83954922
63regulation of telomere maintenance via telomerase (GO:0032210)2.83311656
64negative regulation of keratinocyte proliferation (GO:0010839)2.82952258
65establishment or maintenance of bipolar cell polarity (GO:0061245)2.82865970
66establishment or maintenance of apical/basal cell polarity (GO:0035088)2.82865970
67embryonic foregut morphogenesis (GO:0048617)2.82588110
68heterochromatin organization (GO:0070828)2.81946413
69protein polyglutamylation (GO:0018095)2.81254486
70dorsal/ventral neural tube patterning (GO:0021904)2.80499727
71stress granule assembly (GO:0034063)2.78653268
72lung-associated mesenchyme development (GO:0060484)2.77500040
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.77255835
74positive regulation of triglyceride biosynthetic process (GO:0010867)2.75772514
75negative regulation of catenin import into nucleus (GO:0035414)2.74920644
76establishment of planar polarity (GO:0001736)2.73874618
77establishment of tissue polarity (GO:0007164)2.73874618
78negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.73348777
79oocyte development (GO:0048599)2.71094178
80multicellular organism reproduction (GO:0032504)2.70762768
81ectoderm development (GO:0007398)2.70611951
82peptidyl-arginine methylation (GO:0018216)2.69079447
83peptidyl-arginine N-methylation (GO:0035246)2.69079447
84negative regulation of cell cycle arrest (GO:0071157)2.69020157
85interferon-gamma secretion (GO:0072643)2.68860549
86negative regulation of Ras GTPase activity (GO:0034261)2.65318407
87neural tube formation (GO:0001841)2.64904683
88anterior/posterior axis specification, embryo (GO:0008595)2.64871083
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64513520
90histone H3-K4 methylation (GO:0051568)2.64513437
91regulation of acrosome reaction (GO:0060046)2.61920556
92epithelial cell fate commitment (GO:0072148)2.61849693
93histone H4-K12 acetylation (GO:0043983)2.60776920
94ventricular septum development (GO:0003281)2.60584208
95regulation of ruffle assembly (GO:1900027)2.60322345
96calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.60083145
97cell-cell junction maintenance (GO:0045217)2.57944757
98regulation of histone phosphorylation (GO:0033127)2.56129053
99synapse assembly (GO:0007416)2.55987870
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55950570
101somite rostral/caudal axis specification (GO:0032525)2.55873428
102response to food (GO:0032094)2.54785542
103cell communication involved in cardiac conduction (GO:0086065)2.54338234
104positive regulation of CREB transcription factor activity (GO:0032793)2.54265686
105kidney morphogenesis (GO:0060993)2.52817791
106water homeostasis (GO:0030104)2.52343304
107epithelial cell-cell adhesion (GO:0090136)2.51410969
108molting cycle (GO:0042303)2.51224099
109hair cycle (GO:0042633)2.51224099
110lung epithelium development (GO:0060428)2.50920834
111regulation of cardioblast differentiation (GO:0051890)2.50849430
112gastrulation with mouth forming second (GO:0001702)2.50683724
113trivalent inorganic anion homeostasis (GO:0072506)2.50592265
114phosphate ion homeostasis (GO:0055062)2.50592265
115regulation of sister chromatid cohesion (GO:0007063)2.50532501
116keratinocyte proliferation (GO:0043616)2.49747826
117convergent extension (GO:0060026)2.49464779
118columnar/cuboidal epithelial cell development (GO:0002066)2.49436977
119dendritic spine morphogenesis (GO:0060997)2.48321993
120neuron fate determination (GO:0048664)2.47962699
121cell junction maintenance (GO:0034331)2.47819994
122collecting duct development (GO:0072044)2.47718127
123peristalsis (GO:0030432)2.47623477
124surfactant homeostasis (GO:0043129)2.47608342
125negative regulation of glial cell proliferation (GO:0060253)2.46906099
126DNA methylation (GO:0006306)2.46649092
127DNA alkylation (GO:0006305)2.46649092
128segment specification (GO:0007379)2.45858197
129cell migration involved in gastrulation (GO:0042074)2.45847469
130DNA damage response, signal transduction resulting in transcription (GO:0042772)2.44885268
131embryonic process involved in female pregnancy (GO:0060136)2.44579134
132L-fucose catabolic process (GO:0042355)2.43505964
133fucose catabolic process (GO:0019317)2.43505964
134L-fucose metabolic process (GO:0042354)2.43505964
135renal system development (GO:0072001)2.42385429
136mitotic sister chromatid segregation (GO:0000070)2.41894649
137negative regulation of cell cycle G2/M phase transition (GO:1902750)2.41326024
138phosphatidylserine acyl-chain remodeling (GO:0036150)2.40833297
139regulation of telomerase activity (GO:0051972)2.40431764
140somite development (GO:0061053)2.40088500
141ventricular cardiac muscle cell action potential (GO:0086005)2.39729262
142glial cell proliferation (GO:0014009)2.39217497
143negative regulation of cell fate specification (GO:0009996)2.38600628
144neuron fate specification (GO:0048665)2.38445835
145primitive streak formation (GO:0090009)2.38365221
146negative regulation of epidermis development (GO:0045683)2.37452985
147purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37414501
1483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37414501
149transepithelial transport (GO:0070633)2.36525908
150positive regulation of gastrulation (GO:2000543)2.34928137
151dopaminergic neuron differentiation (GO:0071542)2.34709321
152embryonic axis specification (GO:0000578)2.34096336
153opioid receptor signaling pathway (GO:0038003)2.33759656
154negative regulation of telomere maintenance (GO:0032205)2.33399598
155epithelial cell maturation (GO:0002070)2.32858218
156regulation of triglyceride biosynthetic process (GO:0010866)2.32591245
157peptidyl-lysine methylation (GO:0018022)2.32302727
158phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.30872763
159ear development (GO:0043583)2.28588035
160glandular epithelial cell differentiation (GO:0002067)2.27937890
161ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.27079982
162epidermis development (GO:0008544)2.26856510
163nonmotile primary cilium assembly (GO:0035058)2.25777730
164detection of light stimulus involved in sensory perception (GO:0050962)2.25675207
165detection of light stimulus involved in visual perception (GO:0050908)2.25675207
166calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.25243970
167peptidyl-lysine trimethylation (GO:0018023)2.24773167
168auditory receptor cell differentiation (GO:0042491)2.24696365
169negative regulation of cell aging (GO:0090344)2.23094197
170GPI anchor metabolic process (GO:0006505)2.22678673
171spinal cord motor neuron differentiation (GO:0021522)2.20080526
172type B pancreatic cell development (GO:0003323)2.18756373
173sulfate transmembrane transport (GO:1902358)2.17968264
174vocalization behavior (GO:0071625)2.17058363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.27936516
2EZH2_22144423_ChIP-Seq_EOC_Human4.23821833
3SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.17053572
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.97357540
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.94787095
6ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.86518388
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.83645408
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.83645408
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.83645408
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.48221965
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.38450272
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.38049732
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37367432
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.29607839
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.29427321
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27157882
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.23742528
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.23161003
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09977916
20KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.05930036
21* P68_20966046_ChIP-Seq_HELA_Human2.05148835
22NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.02523816
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.92841725
24ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89654896
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86344410
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.84653689
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83291172
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.82462034
29* E2F1_20622854_ChIP-Seq_HELA_Human1.80024524
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.79907081
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76233963
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74635372
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.73203601
34KDM2B_26808549_Chip-Seq_K562_Human1.68330894
35DROSHA_22980978_ChIP-Seq_HELA_Human1.66565213
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.66162580
37SMC4_20622854_ChIP-Seq_HELA_Human1.65080872
38ERA_21632823_ChIP-Seq_H3396_Human1.64470320
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.64412469
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.64327976
41* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64130620
42TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.60615182
43SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.60051213
44VDR_22108803_ChIP-Seq_LS180_Human1.59930047
45REST_21632747_ChIP-Seq_MESCs_Mouse1.58802504
46PHF8_20622854_ChIP-Seq_HELA_Human1.58151296
47PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.57122049
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.56937048
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.55150457
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.53445801
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50037300
52CREB1_26743006_Chip-Seq_LNCaP_Human1.50033408
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.48675716
54* BCL6_27268052_Chip-Seq_Bcells_Human1.47989082
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47194782
56* BCOR_27268052_Chip-Seq_Bcells_Human1.47065079
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46484978
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46438736
59RACK7_27058665_Chip-Seq_MCF-7_Human1.43415044
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43351784
61ZNF263_19887448_ChIP-Seq_K562_Human1.43325541
62CTCF_20526341_ChIP-Seq_ESCs_Human1.41733502
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.40700478
64POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.39293386
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38562939
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37505824
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36910548
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35207906
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35196609
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34922950
71NANOG_18692474_ChIP-Seq_MESCs_Mouse1.33998309
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32854362
73OCT4_19829295_ChIP-Seq_ESCs_Human1.32009701
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.31925420
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30800823
76* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30649867
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.30400692
78SOX2_18692474_ChIP-Seq_MESCs_Mouse1.30239261
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30076510
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29986548
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29002272
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.28840878
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27963289
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27314594
85ATF3_27146783_Chip-Seq_COLON_Human1.27279323
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27133023
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26199767
88ZNF274_21170338_ChIP-Seq_K562_Hela1.26005766
89SA1_27219007_Chip-Seq_Bcells_Human1.25535421
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.24834511
91HOXB7_26014856_ChIP-Seq_BT474_Human1.24788131
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24452282
93* P300_27268052_Chip-Seq_Bcells_Human1.24448190
94CDX2_20551321_ChIP-Seq_CACO-2_Human1.24217582
95P53_21459846_ChIP-Seq_SAOS-2_Human1.23812687
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23551285
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22618153
98RAC3_21632823_ChIP-Seq_H3396_Human1.21754932
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.21255292
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21011268
101LXR_22292898_ChIP-Seq_THP-1_Human1.19550838
102POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.18321233
103RARB_24833708_ChIP-Seq_LIVER_Mouse1.18212811
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18204150
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17859609
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17712534
107CTCF_27219007_Chip-Seq_Bcells_Human1.16805027
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15969872
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15867941
110NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15722996
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15647657
112FOXP1_21924763_ChIP-Seq_HESCs_Human1.14676705
113GATA6_25053715_ChIP-Seq_YYC3_Human1.14333659
114TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13853937
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.13638121
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13225838
117KLF5_25053715_ChIP-Seq_YYC3_Human1.12920612
118NANOG_20526341_ChIP-Seq_ESCs_Human1.12854398
119NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.12679617
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12505933
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12288004
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10849490
123OCT4_20526341_ChIP-Seq_ESCs_Human1.10758348
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10366920
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10331993
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09934282
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09168222
128GATA3_21878914_ChIP-Seq_MCF-7_Human1.08752646
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.07944129
130ESR1_21235772_ChIP-Seq_MCF-7_Human1.07598086
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07300050
132TAF2_19829295_ChIP-Seq_ESCs_Human1.07114503
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03551564
134SA1_27219007_Chip-Seq_ERYTHROID_Human1.03359713
135RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02893965
136EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02893965
137AR_21572438_ChIP-Seq_LNCaP_Human1.02607743
138E2F7_22180533_ChIP-Seq_HELA_Human1.01697685
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01516597
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00701749
141TP53_22127205_ChIP-Seq_IMR90_Human1.00586867
142JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99965702
143KDM2B_26808549_Chip-Seq_DND41_Human0.99871999
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99272208
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98246663
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97542945
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97229122
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96549064
149RNF2_27304074_Chip-Seq_NSC_Mouse0.96425947
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95398894
151FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95123389
152PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95004429
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94363912
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94289565
155* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94274416
156TP63_22573176_ChIP-Seq_HFKS_Human0.94074376
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93863030
158RXR_22108803_ChIP-Seq_LS180_Human0.93438440
159SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93277207
160TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93229374
161FLI1_21867929_ChIP-Seq_CD8_Mouse0.92876356
162BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91687178
163MYC_19829295_ChIP-Seq_ESCs_Human0.91319267
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.90451499
165MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89622065
166* SOX2_21211035_ChIP-Seq_LN229_Human0.89295339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.46921251
2MP0005257_abnormal_intraocular_pressure4.34309513
3MP0003941_abnormal_skin_development3.75430679
4MP0002796_impaired_skin_barrier3.48363428
5MP0000537_abnormal_urethra_morphology2.84384013
6MP0010030_abnormal_orbit_morphology2.68970855
7MP0004264_abnormal_extraembryonic_tissu2.56940842
8MP0002653_abnormal_ependyma_morphology2.55658060
9MP0008877_abnormal_DNA_methylation2.39507873
10MP0003878_abnormal_ear_physiology2.37357176
11MP0005377_hearing/vestibular/ear_phenot2.37357176
12MP0003787_abnormal_imprinting2.27217401
13MP0005501_abnormal_skin_physiology2.26519340
14MP0001188_hyperpigmentation2.23627034
15MP0003890_abnormal_embryonic-extraembry2.22134285
16MP0003119_abnormal_digestive_system2.19729204
17MP0001849_ear_inflammation2.17034212
18MP0000566_synostosis2.16131075
19MP0000579_abnormal_nail_morphology1.98746296
20MP0005076_abnormal_cell_differentiation1.92772359
21MP0003705_abnormal_hypodermis_morpholog1.91268846
22MP0004381_abnormal_hair_follicle1.84090138
23MP0003385_abnormal_body_wall1.75932306
24MP0009379_abnormal_foot_pigmentation1.74966340
25MP0000427_abnormal_hair_cycle1.67096912
26MP0004133_heterotaxia1.66844371
27MP0002098_abnormal_vibrissa_morphology1.66368080
28MP0000462_abnormal_digestive_system1.64211490
29MP0006292_abnormal_olfactory_placode1.59319763
30MP0005409_darkened_coat_color1.58240780
31MP0003283_abnormal_digestive_organ1.57762921
32MP0002909_abnormal_adrenal_gland1.57157705
33MP0002876_abnormal_thyroid_physiology1.56121026
34MP0009053_abnormal_anal_canal1.55272687
35MP0004185_abnormal_adipocyte_glucose1.54828174
36MP0010678_abnormal_skin_adnexa1.53852781
37MP0002249_abnormal_larynx_morphology1.51362564
38MP0001502_abnormal_circadian_rhythm1.48947297
39MP0003011_delayed_dark_adaptation1.46290774
40MP0000467_abnormal_esophagus_morphology1.46002411
41MP0003123_paternal_imprinting1.45269499
42MP0001968_abnormal_touch/_nociception1.45054403
43MP0000534_abnormal_ureter_morphology1.42888432
44MP0000762_abnormal_tongue_morphology1.39835322
45MP0002085_abnormal_embryonic_tissue1.39714497
46MP0002084_abnormal_developmental_patter1.38963520
47MP0003755_abnormal_palate_morphology1.36833739
48MP0005360_urolithiasis1.36233678
49MP0001216_abnormal_epidermal_layer1.34679068
50MP0002822_catalepsy1.34573628
51MP0003453_abnormal_keratinocyte_physiol1.33226142
52MP0008872_abnormal_physiological_respon1.32470988
53MP0000778_abnormal_nervous_system1.32469541
54MP0005367_renal/urinary_system_phenotyp1.31510058
55MP0000516_abnormal_urinary_system1.31510058
56MP0000678_abnormal_parathyroid_gland1.29671949
57MP0005551_abnormal_eye_electrophysiolog1.29545993
58MP0005646_abnormal_pituitary_gland1.29407159
59MP0003861_abnormal_nervous_system1.28424973
60MP0008875_abnormal_xenobiotic_pharmacok1.28290792
61MP0008995_early_reproductive_senescence1.26484782
62MP0004043_abnormal_pH_regulation1.25747681
63MP0002234_abnormal_pharynx_morphology1.24683447
64MP0004858_abnormal_nervous_system1.24365986
65MP0003693_abnormal_embryo_hatching1.22773674
66MP0000383_abnormal_hair_follicle1.22076496
67MP0002060_abnormal_skin_morphology1.21453993
68MP0004957_abnormal_blastocyst_morpholog1.21397292
69MP0005275_abnormal_skin_tensile1.21348278
70MP0005075_abnormal_melanosome_morpholog1.20020354
71MP0003122_maternal_imprinting1.18150338
72MP0001919_abnormal_reproductive_system1.17408440
73MP0000631_abnormal_neuroendocrine_gland1.17276572
74MP0008961_abnormal_basal_metabolism1.16900852
75MP0010771_integument_phenotype1.15207998
76MP0000350_abnormal_cell_proliferation1.14617858
77MP0010352_gastrointestinal_tract_polyps1.13385432
78MP0005394_taste/olfaction_phenotype1.12436131
79MP0005499_abnormal_olfactory_system1.12436131
80MP0003121_genomic_imprinting1.11818152
81MP0000538_abnormal_urinary_bladder1.11747596
82MP0002733_abnormal_thermal_nociception1.11563142
83MP0001346_abnormal_lacrimal_gland1.11134308
84MP0001340_abnormal_eyelid_morphology1.09024928
85MP0001286_abnormal_eye_development1.08308372
86MP0004019_abnormal_vitamin_homeostasis1.07035359
87MP0003935_abnormal_craniofacial_develop1.06987579
88MP0000647_abnormal_sebaceous_gland1.05860621
89MP0003315_abnormal_perineum_morphology1.04818502
90MP0000026_abnormal_inner_ear1.02715413
91MP0002254_reproductive_system_inflammat1.02310156
92MP0003937_abnormal_limbs/digits/tail_de1.01924675
93MP0002089_abnormal_postnatal_growth/wei1.01479933
94MP0004782_abnormal_surfactant_physiolog1.01402795
95MP0002184_abnormal_innervation1.00975959
96MP0000049_abnormal_middle_ear1.00786890
97MP0006276_abnormal_autonomic_nervous1.00002573
98MP0008789_abnormal_olfactory_epithelium0.99861129
99MP0000367_abnormal_coat/_hair0.98537131
100MP0005380_embryogenesis_phenotype0.98194121
101MP0001672_abnormal_embryogenesis/_devel0.98194121
102MP0002736_abnormal_nociception_after0.97785911
103MP0002572_abnormal_emotion/affect_behav0.97374517
104MP0003115_abnormal_respiratory_system0.97031028
105MP0002111_abnormal_tail_morphology0.96065660
106MP0004197_abnormal_fetal_growth/weight/0.94831393
107MP0001697_abnormal_embryo_size0.94506408
108MP0002086_abnormal_extraembryonic_tissu0.93970406
109MP0002557_abnormal_social/conspecific_i0.93335709
110MP0005174_abnormal_tail_pigmentation0.92635022
111MP0000377_abnormal_hair_follicle0.92012904
112MP0004859_abnormal_synaptic_plasticity0.89743792
113MP0001730_embryonic_growth_arrest0.89515533
114MP0004885_abnormal_endolymph0.88734803
115MP0001873_stomach_inflammation0.88639952
116MP0000470_abnormal_stomach_morphology0.86705548
117MP0004742_abnormal_vestibular_system0.86571819
118MP0003111_abnormal_nucleus_morphology0.86147040
119MP0003942_abnormal_urinary_system0.85239226
120MP0003136_yellow_coat_color0.85064849
121MP0005623_abnormal_meninges_morphology0.84073275
122MP0004270_analgesia0.83864357
123MP0002932_abnormal_joint_morphology0.83776394
124MP0000432_abnormal_head_morphology0.82313746
125MP0002088_abnormal_embryonic_growth/wei0.82166008
126MP0002697_abnormal_eye_size0.81205328
127MP0003984_embryonic_growth_retardation0.80888694
128MP0003195_calcinosis0.80874684
129MP0003938_abnormal_ear_development0.80867756
130MP0002116_abnormal_craniofacial_bone0.80787229
131MP0005423_abnormal_somatic_nervous0.80021314
132MP0000015_abnormal_ear_pigmentation0.78875603
133MP0002233_abnormal_nose_morphology0.78621947
134MP0002282_abnormal_trachea_morphology0.77239578
135MP0001486_abnormal_startle_reflex0.77176006
136MP0001293_anophthalmia0.75806088
137MP0005083_abnormal_biliary_tract0.75378757
138MP0009745_abnormal_behavioral_response0.74782135
139MP0009931_abnormal_skin_appearance0.73968739
140MP0002081_perinatal_lethality0.73851192
141MP0006072_abnormal_retinal_apoptosis0.71894808
142MP0002080_prenatal_lethality0.71359261
143MP0009780_abnormal_chondrocyte_physiolo0.71341253
144MP0001970_abnormal_pain_threshold0.71080079
145MP0004924_abnormal_behavior0.70108698
146MP0005386_behavior/neurological_phenoty0.70108698
147MP0002063_abnormal_learning/memory/cond0.69988995
148MP0002210_abnormal_sex_determination0.69970189

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.34521969
2Right ventricular cardiomyopathy (HP:0011663)4.13505164
3Malnutrition (HP:0004395)3.93719503
4Shawl scrotum (HP:0000049)3.47295780
5Pili torti (HP:0003777)3.29476043
6Congenital stationary night blindness (HP:0007642)3.24158767
7Ependymoma (HP:0002888)3.20710554
8Woolly hair (HP:0002224)3.13744709
9Rib fusion (HP:0000902)3.08176238
10Oligomenorrhea (HP:0000876)2.99126549
11Milia (HP:0001056)2.97972160
12Amyotrophic lateral sclerosis (HP:0007354)2.89363517
13Genetic anticipation (HP:0003743)2.84963916
14Abnormality of the astrocytes (HP:0100707)2.80351023
15Astrocytoma (HP:0009592)2.80351023
16Abnormality of small intestinal villus morphology (HP:0011472)2.79639268
17Villous atrophy (HP:0011473)2.79639268
18Fragile nails (HP:0001808)2.74872992
19Pendular nystagmus (HP:0012043)2.72730056
20Esophageal atresia (HP:0002032)2.64016583
21Type II lissencephaly (HP:0007260)2.62790702
22Selective tooth agenesis (HP:0001592)2.62208490
23Plantar hyperkeratosis (HP:0007556)2.62200506
24Hypotrichosis (HP:0001006)2.60013464
25Abnormality of midbrain morphology (HP:0002418)2.53442533
26Molar tooth sign on MRI (HP:0002419)2.53442533
27Abnormality of the labia minora (HP:0012880)2.52565563
28Abnormality of nail color (HP:0100643)2.51543417
29Onycholysis (HP:0001806)2.51341973
30Amelogenesis imperfecta (HP:0000705)2.44950675
31Bilateral microphthalmos (HP:0007633)2.44052851
32Curly hair (HP:0002212)2.43593295
33Erythroderma (HP:0001019)2.40335399
34Abnormality of the lower motor neuron (HP:0002366)2.40231481
35Concave nail (HP:0001598)2.32512221
36Pancreatic fibrosis (HP:0100732)2.31523615
37Slow-growing hair (HP:0002217)2.29525380
38Abnormality of hair growth rate (HP:0011363)2.29525380
39Agitation (HP:0000713)2.29408004
40Cerebellar dysplasia (HP:0007033)2.26198174
41Nephronophthisis (HP:0000090)2.23036829
42Attenuation of retinal blood vessels (HP:0007843)2.21170924
43Conical tooth (HP:0000698)2.18833846
44Decreased central vision (HP:0007663)2.18786124
45Pancreatic cysts (HP:0001737)2.18365158
46True hermaphroditism (HP:0010459)2.15672422
47Abnormal rod and cone electroretinograms (HP:0008323)2.14087974
48Abnormality of the salivary glands (HP:0010286)2.12677512
49Supernumerary nipples (HP:0002558)2.12657915
50Stomach cancer (HP:0012126)2.08764437
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.08291700
52Visual hallucinations (HP:0002367)2.07543892
53Glioma (HP:0009733)2.06140241
54Abnormality of the dental root (HP:0006486)2.03907889
55Taurodontia (HP:0000679)2.03907889
56Abnormality of permanent molar morphology (HP:0011071)2.03907889
57Nail dystrophy (HP:0008404)2.03312851
58Renal dysplasia (HP:0000110)2.02580138
59Abnormality of the nasal septum (HP:0000419)2.00880255
60Morphological abnormality of the middle ear (HP:0008609)2.00846484
61Heterotopia (HP:0002282)2.00462516
62Lip pit (HP:0100267)1.98887120
63Hyperventilation (HP:0002883)1.97139141
64Labial hypoplasia (HP:0000066)1.96732299
65Neoplasm of the heart (HP:0100544)1.95539788
66Abnormality of the renal medulla (HP:0100957)1.95488538
67Aplasia cutis congenita (HP:0001057)1.95152855
68Cystic liver disease (HP:0006706)1.94765176
69Non-midline cleft lip (HP:0100335)1.94689617
70Aplasia/hypoplasia of the uterus (HP:0008684)1.93681469
71Septate vagina (HP:0001153)1.93275442
72Abnormality of the aortic arch (HP:0012303)1.91614118
73Palmoplantar hyperkeratosis (HP:0000972)1.90889106
74Delayed CNS myelination (HP:0002188)1.90717197
75Bony spicule pigmentary retinopathy (HP:0007737)1.90429193
76Gastrointestinal atresia (HP:0002589)1.89763495
77Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88198208
78Abnormal number of incisors (HP:0011064)1.87621326
79Tubular atrophy (HP:0000092)1.87167677
80Absent forearm bone (HP:0003953)1.86211195
81Aplasia involving forearm bones (HP:0009822)1.86211195
82Patellar aplasia (HP:0006443)1.85624569
83Absent radius (HP:0003974)1.85607012
84Palmar hyperkeratosis (HP:0010765)1.85094209
85Proximal placement of thumb (HP:0009623)1.84022110
86Severe muscular hypotonia (HP:0006829)1.82956504
87Facial hemangioma (HP:0000329)1.81669605
88Hand muscle atrophy (HP:0009130)1.81407460
89Ventricular tachycardia (HP:0004756)1.81133523
90Furrowed tongue (HP:0000221)1.80813567
91Hyperglycinuria (HP:0003108)1.80224005
92Maternal diabetes (HP:0009800)1.79994986
93Deviation of the thumb (HP:0009603)1.79583291
94Sparse scalp hair (HP:0002209)1.79472794
95Depressed nasal tip (HP:0000437)1.79298395
96Cortical dysplasia (HP:0002539)1.79163005
97Hypoplasia of the pons (HP:0012110)1.79062883
98Short humerus (HP:0005792)1.78371566
99Abnormality of the pons (HP:0007361)1.76762092
100Hypoplastic labia majora (HP:0000059)1.76348678
101Decreased circulating renin level (HP:0003351)1.76252606
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75828133
103Hepatoblastoma (HP:0002884)1.75729726
104Hypogonadotrophic hypogonadism (HP:0000044)1.74898978
105Aplasia/hypoplasia of the humerus (HP:0006507)1.74780519
106Duplicated collecting system (HP:0000081)1.74750311
107Abnormality of molar morphology (HP:0011070)1.74744562
108Abnormality of molar (HP:0011077)1.74744562
109Ankyloglossia (HP:0010296)1.74277871
110Oligodontia (HP:0000677)1.73588499
111Abnormality of the renal collecting system (HP:0004742)1.73571395
112Bronchomalacia (HP:0002780)1.73072836
113Alopecia of scalp (HP:0002293)1.72774462
114Lissencephaly (HP:0001339)1.72749340
115Atrophic scars (HP:0001075)1.72585819
116Hypoplastic female external genitalia (HP:0012815)1.72339847
117Turricephaly (HP:0000262)1.72169329
118Abnormal blistering of the skin (HP:0008066)1.72081620
119Congenital ichthyosiform erythroderma (HP:0007431)1.72007009
120Chronic hepatic failure (HP:0100626)1.71947538
121Testicular atrophy (HP:0000029)1.71900040
122Abnormality of the dental pulp (HP:0006479)1.71313727
123Abnormal hair laboratory examination (HP:0003328)1.70867015
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.69939328
125Aplasia/Hypoplasia of the patella (HP:0006498)1.69774119
126Malignant gastrointestinal tract tumors (HP:0006749)1.69088347
127Gastrointestinal carcinoma (HP:0002672)1.69088347
128Abnormality of the labia (HP:0000058)1.68200201
129Anophthalmia (HP:0000528)1.67508476
130Missing ribs (HP:0000921)1.67042627
131Uterine leiomyosarcoma (HP:0002891)1.66856270
132Leiomyosarcoma (HP:0100243)1.66856270
133Parakeratosis (HP:0001036)1.65310278
134Hypoplasia of the uterus (HP:0000013)1.64907600
135Sclerocornea (HP:0000647)1.64858988
136Pachygyria (HP:0001302)1.64414007
137Hemivertebrae (HP:0002937)1.64300899
138Anal stenosis (HP:0002025)1.63582024
139Corneal erosion (HP:0200020)1.63447496
140Abnormality of the renal cortex (HP:0011035)1.61485019
141Abnormality of the musculature of the hand (HP:0001421)1.60775873
142Anonychia (HP:0001798)1.60374169
143Abnormality of the costochondral junction (HP:0000919)1.60234356
144Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59861949
145Oral leukoplakia (HP:0002745)1.59716438
146Poikiloderma (HP:0001029)1.59078810
147Optic nerve coloboma (HP:0000588)1.59010853
148Broad distal phalanx of finger (HP:0009836)1.58706356
149Ectropion (HP:0000656)1.58670811
150Polygenic inheritance (HP:0010982)1.58270951
151Wide cranial sutures (HP:0010537)1.56502483
152Abnormality of the labia majora (HP:0012881)1.56052022
153Preaxial hand polydactyly (HP:0001177)1.55692463
154Hypoplasia of dental enamel (HP:0006297)1.55431102
155Biliary tract neoplasm (HP:0100574)1.55031039
156Abnormality of abdominal situs (HP:0011620)1.54813654
157Abdominal situs inversus (HP:0003363)1.54813654
158High anterior hairline (HP:0009890)1.54505740
159Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54400497
160Vertebral hypoplasia (HP:0008417)1.54400497
161Sparse eyelashes (HP:0000653)1.54399746
162Abnormal biliary tract physiology (HP:0012439)1.53424773
163Bile duct proliferation (HP:0001408)1.53424773
164Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.53044553
165Short 4th metacarpal (HP:0010044)1.53044553
166Shallow orbits (HP:0000586)1.52029420
167Renal duplication (HP:0000075)1.51615895
168Dehydration (HP:0001944)1.51525938
169Hypoplasia of the radius (HP:0002984)1.50663314
170Coronal craniosynostosis (HP:0004440)1.50259670
171Decreased electroretinogram (ERG) amplitude (HP:0000654)1.49588668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.68979647
2KSR24.19407302
3PIK3CA3.90035481
4MAP3K23.86218823
5MET3.04965351
6MAP3K123.01374013
7WNK42.99741120
8CASK2.98154541
9EPHA22.64205514
10LATS22.62128838
11ADRBK22.47476340
12CDK122.26018674
13LATS12.13414203
14EEF2K2.11948841
15MAP3K112.06946421
16MAP2K22.01558029
17MAP2K61.98913393
18MUSK1.97996672
19MAPKAPK31.92080923
20TYRO31.91955852
21MARK11.89321879
22MAP3K91.86077606
23MAP4K21.75837902
24NME11.74152507
25GRK11.71384231
26TLK11.71267259
27TRIM281.58257085
28RPS6KB21.55316559
29DDR21.46142871
30MAP2K11.43554731
31NTRK31.40548272
32MAP2K41.38117933
33TAOK31.36884532
34ICK1.32328968
35STK391.30696956
36TNK21.26221429
37NTRK21.20512427
38EPHB21.19622981
39TTK1.18366893
40INSRR1.12215071
41DYRK21.10729097
42RIPK11.07794229
43RET1.03261838
44FER1.03139451
45PDGFRA1.01556093
46STK38L0.99000645
47PTK20.97997262
48TAF10.95640737
49MATK0.94048013
50UHMK10.93791325
51PAK40.90378557
52KSR10.89941392
53CDK90.89365314
54FRK0.87764622
55TAOK10.86628231
56SIK30.85925842
57PKN20.84663122
58ACVR1B0.83726923
59CHUK0.83340353
60BUB10.81112027
61VRK20.80582355
62MAP3K60.77296365
63GRK60.76769873
64BCR0.76138771
65MINK10.75770734
66ERN10.73917275
67PRKCI0.73832132
68PAK60.72031864
69MAP3K80.71662673
70FGFR10.70630671
71RPS6KA20.70383545
72CHEK20.69251234
73STK110.69170900
74EPHA30.68479372
75OXSR10.66732901
76SIK20.66729125
77MAP3K10.65521588
78CSNK1G30.64588159
79CDK70.63896798
80AURKA0.62030364
81WNK30.60589216
82NEK10.60135979
83PAK30.59054667
84STK380.58765401
85FGFR20.58463826
86MTOR0.56891498
87ALK0.56035249
88SMG10.55788070
89TGFBR10.55571884
90PRKCZ0.54428394
91MARK20.53903393
92ERBB20.52826579
93NEK20.52680385
94WNK10.52409044
95CSNK1A1L0.51934870
96SIK10.51098666
97MAPK130.50959877
98CSNK1G20.50485193
99DYRK1B0.50430721
100ARAF0.50290933
101MAPK150.50250426
102TXK0.50217060
103CAMK1D0.49968716
104PHKG20.49449941
105PHKG10.49449941
106IKBKB0.48289908
107PINK10.48213236
108PLK10.48023521
109DYRK30.46944804
110KDR0.46051697
111CDC42BPA0.45797853
112AURKB0.45005663
113GRK50.44667851
114TNIK0.44352483
115AKT20.43961770
116CSNK1G10.43758114
117AKT30.42807206
118CAMK1G0.42215386
119MELK0.42202997
120HIPK20.41353565
121CSNK1A10.41340921
122PRKD20.41297511
123MAP2K70.41008526
124EPHB10.40409560
125PNCK0.40341575
126BCKDK0.40176629
127TRIB30.40088156
128CSNK1D0.39603339
129MAPK80.39416574
130ADRBK10.38922128
131IRAK20.38729199
132ERBB40.38664231
133RPS6KA10.38509588
134BMX0.37586032
135CSNK1E0.37332127
136MAP3K100.36907352
137LMTK20.36106597
138PASK0.36040002
139PRKAA10.34502467
140CHEK10.34362876
141DAPK10.33749979
142DMPK0.33232610
143CDK180.33114243
144PRKCH0.32813519
145PRKCE0.31759611
146ZAK0.30909573
147BMPR1B0.30529729
148CDK150.29361769
149PTK60.28719573
150MAP3K40.26603617
151ATR0.26481117
152ERBB30.26146211
153CDK20.25955758
154STK30.25480562
155CDK11A0.25376278
156PRKD30.25199951
157CDK60.24947725

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.33939369
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.32121289
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.13962012
4Mineral absorption_Homo sapiens_hsa049782.87712104
5Linoleic acid metabolism_Homo sapiens_hsa005912.77352316
6Hippo signaling pathway_Homo sapiens_hsa043902.58367201
7Basal cell carcinoma_Homo sapiens_hsa052172.55362277
8Thyroid cancer_Homo sapiens_hsa052162.49476380
9Bladder cancer_Homo sapiens_hsa052192.40968819
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39432474
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.34024534
12Sulfur relay system_Homo sapiens_hsa041222.24322183
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17556949
14Hedgehog signaling pathway_Homo sapiens_hsa043402.10284612
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.06683983
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05540961
17Tight junction_Homo sapiens_hsa045302.03764193
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99196866
19Adherens junction_Homo sapiens_hsa045201.98780998
20Ether lipid metabolism_Homo sapiens_hsa005651.85623542
21Vitamin digestion and absorption_Homo sapiens_hsa049771.83948826
22Endometrial cancer_Homo sapiens_hsa052131.82278173
23mTOR signaling pathway_Homo sapiens_hsa041501.77085621
24Selenocompound metabolism_Homo sapiens_hsa004501.75431602
25Dorso-ventral axis formation_Homo sapiens_hsa043201.74154303
26Axon guidance_Homo sapiens_hsa043601.71487110
27Colorectal cancer_Homo sapiens_hsa052101.65109101
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55880681
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55361075
30Gap junction_Homo sapiens_hsa045401.54682906
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49438102
32Long-term depression_Homo sapiens_hsa047301.47944045
33Caffeine metabolism_Homo sapiens_hsa002321.47490148
34Melanogenesis_Homo sapiens_hsa049161.46967038
35Oocyte meiosis_Homo sapiens_hsa041141.41551392
36Salivary secretion_Homo sapiens_hsa049701.40937503
37ErbB signaling pathway_Homo sapiens_hsa040121.40073428
38Ovarian steroidogenesis_Homo sapiens_hsa049131.38113397
39Notch signaling pathway_Homo sapiens_hsa043301.36597268
40TGF-beta signaling pathway_Homo sapiens_hsa043501.32615615
41VEGF signaling pathway_Homo sapiens_hsa043701.30850698
42RNA transport_Homo sapiens_hsa030131.28627232
43MicroRNAs in cancer_Homo sapiens_hsa052061.27085155
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27081408
45Regulation of autophagy_Homo sapiens_hsa041401.26720668
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.26672238
47Chemical carcinogenesis_Homo sapiens_hsa052041.25483647
48ABC transporters_Homo sapiens_hsa020101.24045042
49Retinol metabolism_Homo sapiens_hsa008301.22561079
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22493281
51Sphingolipid metabolism_Homo sapiens_hsa006001.22377002
52Nitrogen metabolism_Homo sapiens_hsa009101.22176119
53Basal transcription factors_Homo sapiens_hsa030221.21966574
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21842834
55Histidine metabolism_Homo sapiens_hsa003401.21382130
56Long-term potentiation_Homo sapiens_hsa047201.20211331
57Wnt signaling pathway_Homo sapiens_hsa043101.18859857
58GnRH signaling pathway_Homo sapiens_hsa049121.18336241
59Proteoglycans in cancer_Homo sapiens_hsa052051.18219434
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18158082
61Lysine degradation_Homo sapiens_hsa003101.17972918
62Bile secretion_Homo sapiens_hsa049761.17046724
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15244115
64Arachidonic acid metabolism_Homo sapiens_hsa005901.14481267
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13318884
66Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10545681
67Non-small cell lung cancer_Homo sapiens_hsa052231.08799025
68Estrogen signaling pathway_Homo sapiens_hsa049151.07968363
69Renal cell carcinoma_Homo sapiens_hsa052111.07657425
70Nicotine addiction_Homo sapiens_hsa050331.07456805
71Chronic myeloid leukemia_Homo sapiens_hsa052201.06522916
72mRNA surveillance pathway_Homo sapiens_hsa030151.06259872
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05526556
74Butanoate metabolism_Homo sapiens_hsa006501.05147350
75Cocaine addiction_Homo sapiens_hsa050301.04705392
76Steroid hormone biosynthesis_Homo sapiens_hsa001401.04369838
77Choline metabolism in cancer_Homo sapiens_hsa052311.04252324
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04133554
79Tryptophan metabolism_Homo sapiens_hsa003801.03595434
80Spliceosome_Homo sapiens_hsa030401.02293449
81Glioma_Homo sapiens_hsa052141.01540928
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99293299
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97187696
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96807965
85Type II diabetes mellitus_Homo sapiens_hsa049300.96600828
86Cell cycle_Homo sapiens_hsa041100.96367204
87Oxidative phosphorylation_Homo sapiens_hsa001900.94380281
88p53 signaling pathway_Homo sapiens_hsa041150.93406882
89Pathways in cancer_Homo sapiens_hsa052000.92144672
90Base excision repair_Homo sapiens_hsa034100.89996279
91Pancreatic cancer_Homo sapiens_hsa052120.88249137
92Morphine addiction_Homo sapiens_hsa050320.87932313
93Melanoma_Homo sapiens_hsa052180.86561887
94Glutamatergic synapse_Homo sapiens_hsa047240.85254663
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83602695
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.81882295
97Rap1 signaling pathway_Homo sapiens_hsa040150.81469660
98Mismatch repair_Homo sapiens_hsa034300.79842281
99RNA polymerase_Homo sapiens_hsa030200.77784863
100Fatty acid biosynthesis_Homo sapiens_hsa000610.76868148
101Fanconi anemia pathway_Homo sapiens_hsa034600.75618201
102Oxytocin signaling pathway_Homo sapiens_hsa049210.75196000
103Insulin secretion_Homo sapiens_hsa049110.74370175
104Circadian entrainment_Homo sapiens_hsa047130.72950849
105Protein digestion and absorption_Homo sapiens_hsa049740.72098203
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71990922
107Steroid biosynthesis_Homo sapiens_hsa001000.71941845
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71593095
109Peroxisome_Homo sapiens_hsa041460.70594480
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69217580
111Homologous recombination_Homo sapiens_hsa034400.68072580
112Synaptic vesicle cycle_Homo sapiens_hsa047210.67063866
113Olfactory transduction_Homo sapiens_hsa047400.67038199
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66868039
115Primary immunodeficiency_Homo sapiens_hsa053400.66715734
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65171833
117Phenylalanine metabolism_Homo sapiens_hsa003600.64467032
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63859054
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.62835989
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.62649748
121Sulfur metabolism_Homo sapiens_hsa009200.61996335
122Shigellosis_Homo sapiens_hsa051310.61935362
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61918799
124Taste transduction_Homo sapiens_hsa047420.61793958
125Dopaminergic synapse_Homo sapiens_hsa047280.59863399
126Glycerolipid metabolism_Homo sapiens_hsa005610.58085796
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57797308
128Serotonergic synapse_Homo sapiens_hsa047260.57742265
129Focal adhesion_Homo sapiens_hsa045100.57621080
130T cell receptor signaling pathway_Homo sapiens_hsa046600.57496939
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57036258
132Acute myeloid leukemia_Homo sapiens_hsa052210.56160403
133Fat digestion and absorption_Homo sapiens_hsa049750.56110924
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55756310
135Renin-angiotensin system_Homo sapiens_hsa046140.55054386
136Prostate cancer_Homo sapiens_hsa052150.53846289
137Prion diseases_Homo sapiens_hsa050200.53463735
138Insulin signaling pathway_Homo sapiens_hsa049100.52606923
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52240604
140Pancreatic secretion_Homo sapiens_hsa049720.52239010
141Small cell lung cancer_Homo sapiens_hsa052220.52110580
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51915902
143Inositol phosphate metabolism_Homo sapiens_hsa005620.51878579
144Cholinergic synapse_Homo sapiens_hsa047250.51756551
145Circadian rhythm_Homo sapiens_hsa047100.51182928
146AMPK signaling pathway_Homo sapiens_hsa041520.51058520
147DNA replication_Homo sapiens_hsa030300.49990152
148Endocytosis_Homo sapiens_hsa041440.49430517
149Parkinsons disease_Homo sapiens_hsa050120.49121054
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48433991
151RNA degradation_Homo sapiens_hsa030180.47424558
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46764512
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.46643652
154GABAergic synapse_Homo sapiens_hsa047270.46405006
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45891685
156Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45202748
157Amphetamine addiction_Homo sapiens_hsa050310.45120204
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44844986
159Huntingtons disease_Homo sapiens_hsa050160.44243730
160Metabolic pathways_Homo sapiens_hsa011000.44053707
161Collecting duct acid secretion_Homo sapiens_hsa049660.43865482
162Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43029717
163ECM-receptor interaction_Homo sapiens_hsa045120.42845293
164MAPK signaling pathway_Homo sapiens_hsa040100.42303745
165Gastric acid secretion_Homo sapiens_hsa049710.41510771
166Ras signaling pathway_Homo sapiens_hsa040140.41307881
167Glycosaminoglycan degradation_Homo sapiens_hsa005310.40710811
168Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34902165
169Cardiac muscle contraction_Homo sapiens_hsa042600.32809856

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