CCDC125

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.80035638
2tryptophan catabolic process (GO:0006569)5.32121177
3indole-containing compound catabolic process (GO:0042436)5.32121177
4indolalkylamine catabolic process (GO:0046218)5.32121177
5leukocyte aggregation (GO:0070486)5.07074978
6killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.93533650
7disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.93533650
8indolalkylamine metabolic process (GO:0006586)4.90384845
9kynurenine metabolic process (GO:0070189)4.86861179
10ribosomal small subunit assembly (GO:0000028)4.68116547
11negative regulation of phagocytosis (GO:0050765)4.56426908
12tryptophan metabolic process (GO:0006568)4.49380336
13regulation of hippo signaling (GO:0035330)4.39193983
14neutrophil mediated immunity (GO:0002446)4.34636830
15positive regulation of gamma-delta T cell activation (GO:0046645)4.28702655
16regulation of pigment cell differentiation (GO:0050932)4.21615829
17defense response to fungus (GO:0050832)4.16757260
18response to peptidoglycan (GO:0032494)4.15543836
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15327853
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.15327853
21positive regulation of developmental pigmentation (GO:0048087)4.14675907
22neutrophil activation involved in immune response (GO:0002283)4.14416765
23signal peptide processing (GO:0006465)4.13889165
24monoubiquitinated protein deubiquitination (GO:0035520)4.07400214
25modulation of growth of symbiont involved in interaction with host (GO:0044144)4.06056289
26regulation of growth of symbiont in host (GO:0044126)4.06056289
27negative regulation of growth of symbiont in host (GO:0044130)4.06056289
28negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.06056289
29response to fungus (GO:0009620)4.01976331
30protein K48-linked deubiquitination (GO:0071108)4.00115863
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.96848866
32interkinetic nuclear migration (GO:0022027)3.96687702
33respiratory burst (GO:0045730)3.83653853
34disruption of cells of other organism (GO:0044364)3.80071694
35killing of cells of other organism (GO:0031640)3.80071694
36neural tube formation (GO:0001841)3.72229556
37cellular response to ethanol (GO:0071361)3.71864840
38detection of bacterium (GO:0016045)3.69765920
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69039233
40regulation of B cell receptor signaling pathway (GO:0050855)3.68713876
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64118391
42NAD biosynthetic process (GO:0009435)3.62460607
43detection of other organism (GO:0098543)3.62316445
44behavioral response to nicotine (GO:0035095)3.61279955
45detection of light stimulus involved in visual perception (GO:0050908)3.61262144
46detection of light stimulus involved in sensory perception (GO:0050962)3.61262144
47regulation of establishment of cell polarity (GO:2000114)3.56406441
48cilium movement (GO:0003341)3.55272600
49fucose catabolic process (GO:0019317)3.54763654
50L-fucose metabolic process (GO:0042354)3.54763654
51L-fucose catabolic process (GO:0042355)3.54763654
52cellular response to zinc ion (GO:0071294)3.51919337
53establishment of protein localization to Golgi (GO:0072600)3.51087563
54flavonoid metabolic process (GO:0009812)3.50906201
55antigen processing and presentation of endogenous antigen (GO:0019883)3.50354200
56reactive oxygen species biosynthetic process (GO:1903409)3.50029869
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47049926
58regulation of gene silencing by RNA (GO:0060966)3.46728873
59regulation of posttranscriptional gene silencing (GO:0060147)3.46728873
60regulation of gene silencing by miRNA (GO:0060964)3.46728873
61indole-containing compound metabolic process (GO:0042430)3.44692040
62superoxide anion generation (GO:0042554)3.44480893
63snRNA transcription (GO:0009301)3.43755601
64neutrophil activation (GO:0042119)3.42478978
65myeloid leukocyte mediated immunity (GO:0002444)3.37657978
66negative regulation of translation, ncRNA-mediated (GO:0040033)3.37345146
67regulation of translation, ncRNA-mediated (GO:0045974)3.37345146
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.37345146
69drug catabolic process (GO:0042737)3.33795068
70definitive hemopoiesis (GO:0060216)3.33743796
71axoneme assembly (GO:0035082)3.33251563
72lipid translocation (GO:0034204)3.32894191
73phospholipid translocation (GO:0045332)3.32894191
74benzene-containing compound metabolic process (GO:0042537)3.32151158
75cellular ketone body metabolic process (GO:0046950)3.31772763
76photoreceptor cell maintenance (GO:0045494)3.31079503
77reflex (GO:0060004)3.30161249
78oxidative demethylation (GO:0070989)3.24194219
79regulation of establishment or maintenance of cell polarity (GO:0032878)3.22154877
80protein K63-linked deubiquitination (GO:0070536)3.20753832
81sphingoid metabolic process (GO:0046519)3.20354394
82amine catabolic process (GO:0009310)3.13721462
83cellular biogenic amine catabolic process (GO:0042402)3.13721462
84sulfation (GO:0051923)3.13697353
85regulation of B cell differentiation (GO:0045577)3.13228943
86negative regulation of myeloid cell apoptotic process (GO:0033033)3.12123401
87cellular extravasation (GO:0045123)3.09108666
88UDP-N-acetylglucosamine metabolic process (GO:0006047)3.08581110
89thyroid hormone metabolic process (GO:0042403)3.07730932
90lymphoid progenitor cell differentiation (GO:0002320)3.06906425
91positive regulation of B cell differentiation (GO:0045579)3.06304133
92granulocyte activation (GO:0036230)3.05733533
93protein K11-linked deubiquitination (GO:0035871)3.05482715
94DNA deamination (GO:0045006)3.03497854
95aromatic amino acid family catabolic process (GO:0009074)3.02679141
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00547913
97motile cilium assembly (GO:0044458)2.96580786
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96233530
99axonemal dynein complex assembly (GO:0070286)2.95877774
100leukocyte migration involved in inflammatory response (GO:0002523)2.95029202
101negative regulation of sodium ion transport (GO:0010766)2.94411391
102epithelial cilium movement (GO:0003351)2.93697358
103ketone body metabolic process (GO:1902224)2.93541867
104tachykinin receptor signaling pathway (GO:0007217)2.91069630
105defense response to protozoan (GO:0042832)2.90893291
106angiogenesis involved in wound healing (GO:0060055)2.90752377
107behavioral response to ethanol (GO:0048149)2.89410548
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89400415
109regulation of gamma-delta T cell activation (GO:0046643)2.86592526
110response to protozoan (GO:0001562)2.83886910
111striated muscle atrophy (GO:0014891)2.82448409
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82065568
113pyridine nucleotide biosynthetic process (GO:0019363)2.78869341
114nicotinamide nucleotide biosynthetic process (GO:0019359)2.78869341
115serotonin metabolic process (GO:0042428)2.75242851
116regulation of sarcomere organization (GO:0060297)2.74832598
117viral transcription (GO:0019083)2.74293494
118regulation of gamma-delta T cell differentiation (GO:0045586)2.72272404
119leukocyte mediated cytotoxicity (GO:0001909)2.72127086
120T cell migration (GO:0072678)2.70861485
121aromatic amino acid family metabolic process (GO:0009072)2.69938602
122exogenous drug catabolic process (GO:0042738)2.69657797
123macrophage differentiation (GO:0030225)2.67960124
124antigen processing and presentation via MHC class Ib (GO:0002475)2.66972352
125cellular response to exogenous dsRNA (GO:0071360)2.66539706
126DNA methylation involved in gamete generation (GO:0043046)2.66509088
127primary amino compound metabolic process (GO:1901160)2.65064871
128mast cell activation (GO:0045576)2.64478498
129translational termination (GO:0006415)2.61759339
130cilium organization (GO:0044782)2.60430306
131phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.60094019
132T cell homeostasis (GO:0043029)2.59396633
133cellular response to sterol (GO:0036315)2.58898506
134interferon-gamma production (GO:0032609)2.57160934
135immunoglobulin mediated immune response (GO:0016064)2.57107974
136alkaloid metabolic process (GO:0009820)2.57005938
137negative regulation of systemic arterial blood pressure (GO:0003085)2.56850306
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.56695602
139regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.56662403
140auditory receptor cell stereocilium organization (GO:0060088)2.56661645
141cytoplasmic mRNA processing body assembly (GO:0033962)2.55617796
142skeletal muscle adaptation (GO:0043501)2.55164781
143regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54647782
144positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.54239570
145telomere maintenance via semi-conservative replication (GO:0032201)2.53638148
146cilium assembly (GO:0042384)2.53412447
147histone H3-K9 methylation (GO:0051567)2.52077649
148leukocyte degranulation (GO:0043299)2.50818873
149regulation of T cell receptor signaling pathway (GO:0050856)2.50335450
150regulation of mast cell activation (GO:0033003)2.49804946
151dendritic cell chemotaxis (GO:0002407)2.49156589
152negative regulation of interleukin-12 production (GO:0032695)2.48524423
153detection of external biotic stimulus (GO:0098581)2.48388803
154mature B cell differentiation (GO:0002335)2.48270663
155detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47724902
156negative regulation of mast cell activation (GO:0033004)2.47489415
157protein targeting to lysosome (GO:0006622)2.47480043
158establishment of protein localization to vacuole (GO:0072666)2.47480043
159protein targeting to vacuole (GO:0006623)2.47480043
160mature B cell differentiation involved in immune response (GO:0002313)2.47125394
161negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47016614
162SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.46890977
163leukotriene biosynthetic process (GO:0019370)2.46644129
164response to interferon-beta (GO:0035456)2.45687362
165cAMP catabolic process (GO:0006198)2.45030264
166hydrogen peroxide biosynthetic process (GO:0050665)2.44656586
167ribosomal small subunit biogenesis (GO:0042274)2.44349600
168rRNA catabolic process (GO:0016075)2.44072219
169protein prenylation (GO:0018342)2.43862163
170prenylation (GO:0097354)2.43862163
171negative regulation of immunoglobulin mediated immune response (GO:0002890)2.43682496
172negative regulation of B cell mediated immunity (GO:0002713)2.43682496
173maturation of SSU-rRNA (GO:0030490)2.43541789
174negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42587847
175gamma-aminobutyric acid transport (GO:0015812)2.40789495
176pentose metabolic process (GO:0019321)2.40645378
177cell killing (GO:0001906)2.40356311
178necroptotic process (GO:0070266)2.40342709
179left/right axis specification (GO:0070986)2.40214037
180B cell receptor signaling pathway (GO:0050853)2.40148966
181cotranslational protein targeting to membrane (GO:0006613)2.39254046
182production of molecular mediator involved in inflammatory response (GO:0002532)2.39087545
183leukocyte cell-cell adhesion (GO:0007159)2.38856457
184protein targeting to ER (GO:0045047)2.38708516
185leukotriene metabolic process (GO:0006691)2.38511434
186myeloid cell activation involved in immune response (GO:0002275)2.37990194
187response to interleukin-15 (GO:0070672)2.35724962
188negative regulation of granulocyte differentiation (GO:0030853)2.35203013
189dendritic cell migration (GO:0036336)2.34994771
190cellular response to interleukin-15 (GO:0071350)2.34421869
191leukocyte homeostasis (GO:0001776)2.33939392
192lymphocyte homeostasis (GO:0002260)2.32827787
193regulation of chemokine biosynthetic process (GO:0045073)2.31129605
194positive regulation of T cell mediated cytotoxicity (GO:0001916)2.30843258
195hepatocyte apoptotic process (GO:0097284)2.30681604
196negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27230488
197platelet dense granule organization (GO:0060155)2.26541538
198regulation of interleukin-8 biosynthetic process (GO:0045414)2.25150744
199DNA strand elongation involved in DNA replication (GO:0006271)2.24561776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.89955979
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.63547416
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55166315
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.28151119
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24814866
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18132699
7SCL_19346495_ChIP-Seq_HPC-7_Human3.12426452
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06952801
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04016564
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02388922
11GBX2_23144817_ChIP-Seq_PC3_Human2.99745361
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.99194926
13VDR_22108803_ChIP-Seq_LS180_Human2.85595179
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77864273
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74803176
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.66136361
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63215684
18ZNF274_21170338_ChIP-Seq_K562_Hela2.61542606
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52584068
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.49261340
21SPI1_23547873_ChIP-Seq_NB4_Human2.46289446
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.45507460
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37871785
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.37788832
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35048629
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29973860
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29802034
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26667666
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.26112723
30EZH2_22144423_ChIP-Seq_EOC_Human2.25322517
31IGF1R_20145208_ChIP-Seq_DFB_Human2.23859302
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20190470
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15335924
34NOTCH1_21737748_ChIP-Seq_TLL_Human2.13397630
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12649152
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10922108
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08790462
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.06278731
39ER_23166858_ChIP-Seq_MCF-7_Human2.04063708
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03989920
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02293142
42VDR_21846776_ChIP-Seq_THP-1_Human2.01777520
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99582837
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.99493982
45TAF15_26573619_Chip-Seq_HEK293_Human1.99148412
46MYB_26560356_Chip-Seq_TH2_Human1.97992776
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95382500
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94432308
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93362351
50AR_21572438_ChIP-Seq_LNCaP_Human1.93134355
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92822739
52STAT3_23295773_ChIP-Seq_U87_Human1.92258044
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.91990490
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91245573
55MYB_26560356_Chip-Seq_TH1_Human1.89904244
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89697112
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.85400028
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85058075
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83508851
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78259197
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.77775523
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75743573
63P300_19829295_ChIP-Seq_ESCs_Human1.74850554
64DROSHA_22980978_ChIP-Seq_HELA_Human1.72981225
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72493392
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72289426
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71858958
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68242197
69VDR_24763502_ChIP-Seq_THP-1_Human1.68073372
70MYC_22102868_ChIP-Seq_BL_Human1.67883019
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66839310
72* TCF4_23295773_ChIP-Seq_U87_Human1.66465391
73SMAD4_21799915_ChIP-Seq_A2780_Human1.66111365
74BCAT_22108803_ChIP-Seq_LS180_Human1.65770822
75MAF_26560356_Chip-Seq_TH1_Human1.65479104
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62790265
77RUNX_20019798_ChIP-Seq_JUKART_Human1.61945168
78UTX_26944678_Chip-Seq_JUKART_Human1.59383295
79EWS_26573619_Chip-Seq_HEK293_Human1.59255571
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58183418
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57929329
82* MYC_18555785_ChIP-Seq_MESCs_Mouse1.56364721
83VDR_23849224_ChIP-Seq_CD4+_Human1.55975867
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55403100
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55403100
86* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53229764
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53047482
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52956273
89AHR_22903824_ChIP-Seq_MCF-7_Human1.52726633
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52701694
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.52303971
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52190680
93TP53_16413492_ChIP-PET_HCT116_Human1.51858542
94FOXP3_21729870_ChIP-Seq_TREG_Human1.51852144
95CBP_20019798_ChIP-Seq_JUKART_Human1.51399008
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51399008
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.49480379
98FUS_26573619_Chip-Seq_HEK293_Human1.48524865
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46745601
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.46083554
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.43240624
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.41654430
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41647389
104PU_27001747_Chip-Seq_BMDM_Mouse1.41427785
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41252632
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40388802
107ELK1_19687146_ChIP-ChIP_HELA_Human1.39377852
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38403761
109AR_25329375_ChIP-Seq_VCAP_Human1.38140565
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37180860
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35415737
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34213491
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33069236
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31409498
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.31386171
116TCF4_22108803_ChIP-Seq_LS180_Human1.31246713
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30373869
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29711224
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29492451
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29026935
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27187761
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.26436520
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25097464
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25052702
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.24722215
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23694270
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23656992
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23647968
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.23358229
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23223585
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21259028
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20766241
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20606957
134SRF_21415370_ChIP-Seq_HL-1_Mouse1.20353244
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.19777801
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19744839
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19711536
138RUNX2_22187159_ChIP-Seq_PCA_Human1.19509835
139CDX2_22108803_ChIP-Seq_LS180_Human1.19161867
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18068440
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17900387
142FLI1_21867929_ChIP-Seq_TH2_Mouse1.17839015
143* SMAD4_21741376_ChIP-Seq_EPCs_Human1.17792076
144RXR_22108803_ChIP-Seq_LS180_Human1.17549777
145FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17225116
146* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15784501
147CIITA_25753668_ChIP-Seq_RAJI_Human1.12980601
148MAF_26560356_Chip-Seq_TH2_Human1.10928017
149KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10843670
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10649210
151E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10214184
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10051592
153NANOG_19829295_ChIP-Seq_ESCs_Human1.09442338
154SOX2_19829295_ChIP-Seq_ESCs_Human1.09442338
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08761079
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08182011
157E2F1_21310950_ChIP-Seq_MCF-7_Human1.07934738
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07326703
159HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06821574
160FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06476319
161* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06063786
162GATA3_27048872_Chip-Seq_THYMUS_Human1.05675918
163SMAD3_21741376_ChIP-Seq_HESCs_Human1.04853190
164RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04776316
165IRF1_19129219_ChIP-ChIP_H3396_Human1.04463576
166CRX_20693478_ChIP-Seq_RETINA_Mouse1.04363102
167TP53_22573176_ChIP-Seq_HFKS_Human1.04300425
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02955747
169SMRT_27268052_Chip-Seq_Bcells_Human1.02565648
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02515162
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02295858
172OCT1_27270436_Chip-Seq_PROSTATE_Human1.01751648
173NANOG_18555785_Chip-Seq_ESCs_Mouse1.01380956
174SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01158910
175SOX2_21211035_ChIP-Seq_LN229_Gbm1.00842491
176EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00540634
177KDM2B_26808549_Chip-Seq_REH_Human1.00087286
178GATA3_26560356_Chip-Seq_TH2_Human0.98486936
179OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98460186
180SPI1_23127762_ChIP-Seq_K562_Human0.98455106
181RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98035696
182CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97401201
183TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97049704
184PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92291588
185ETS1_20019798_ChIP-Seq_JURKAT_Human0.92163803
186PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91671978
187TCF7_22412390_ChIP-Seq_EML_Mouse0.89943374
188MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87571421
189PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87126337
190HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87025671
191MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86840803
192PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86563879
193CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86379179
194GATA1_22025678_ChIP-Seq_K562_Human0.86075501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.88520323
2MP0001835_abnormal_antigen_presentation3.40615672
3MP0002396_abnormal_hematopoietic_system3.40343214
4MP0009785_altered_susceptibility_to3.37197543
5MP0003646_muscle_fatigue3.25789816
6MP0003436_decreased_susceptibility_to2.84420894
7MP0004043_abnormal_pH_regulation2.83465198
8MP0003045_fibrosis2.70355076
9MP0005671_abnormal_response_to2.69437949
10MP0001501_abnormal_sleep_pattern2.65398081
11MP0002419_abnormal_innate_immunity2.64401245
12MP0003724_increased_susceptibility_to2.64212892
13MP0000685_abnormal_immune_system2.57481943
14MP0005025_abnormal_response_to2.53911440
15MP0003763_abnormal_thymus_physiology2.49955444
16MP0005174_abnormal_tail_pigmentation2.41882026
17MP0005551_abnormal_eye_electrophysiolog2.40638021
18MP0001800_abnormal_humoral_immune2.39511559
19MP0005464_abnormal_platelet_physiology2.30909105
20MP0003191_abnormal_cellular_cholesterol2.30335511
21MP0002452_abnormal_antigen_presenting2.26969222
22MP0002420_abnormal_adaptive_immunity2.25975502
23MP0001819_abnormal_immune_cell2.24873135
24MP0005000_abnormal_immune_tolerance2.19888384
25MP0002723_abnormal_immune_serum2.19882806
26MP0002148_abnormal_hypersensitivity_rea2.17010336
27MP0000427_abnormal_hair_cycle2.14049622
28MP0009046_muscle_twitch2.08826617
29MP0001873_stomach_inflammation2.08608179
30MP0001790_abnormal_immune_system2.07461207
31MP0005387_immune_system_phenotype2.07461207
32MP0002876_abnormal_thyroid_physiology2.03968171
33MP0002398_abnormal_bone_marrow2.02454915
34MP0000383_abnormal_hair_follicle1.94873908
35MP0008057_abnormal_DNA_replication1.94180033
36MP0001968_abnormal_touch/_nociception1.90936535
37MP0002405_respiratory_system_inflammati1.90732230
38MP0003303_peritoneal_inflammation1.90602754
39MP0010155_abnormal_intestine_physiology1.89847749
40MP0000716_abnormal_immune_system1.88982193
41MP0001853_heart_inflammation1.88981309
42MP0004808_abnormal_hematopoietic_stem1.85281552
43MP0000490_abnormal_crypts_of1.83366881
44MP0003693_abnormal_embryo_hatching1.80296373
45MP0001545_abnormal_hematopoietic_system1.79396523
46MP0005397_hematopoietic_system_phenotyp1.79396523
47MP0005670_abnormal_white_adipose1.79325438
48MP0002837_dystrophic_cardiac_calcinosis1.78569708
49MP0002166_altered_tumor_susceptibility1.77897151
50MP0000689_abnormal_spleen_morphology1.74598289
51MP0000465_gastrointestinal_hemorrhage1.71897111
52MP0008872_abnormal_physiological_respon1.71516073
53MP0002168_other_aberrant_phenotype1.70721203
54MP0005310_abnormal_salivary_gland1.70587441
55MP0001845_abnormal_inflammatory_respons1.65842742
56MP0002722_abnormal_immune_system1.65148996
57MP0003950_abnormal_plasma_membrane1.63825978
58MP0000015_abnormal_ear_pigmentation1.63499727
59MP0008058_abnormal_DNA_repair1.63475051
60MP0003136_yellow_coat_color1.63222679
61MP0002429_abnormal_blood_cell1.62929396
62MP0008961_abnormal_basal_metabolism1.60341288
63MP0005646_abnormal_pituitary_gland1.60119401
64MP0004147_increased_porphyrin_level1.58995650
65MP0002653_abnormal_ependyma_morphology1.58800490
66MP0005645_abnormal_hypothalamus_physiol1.55253280
67MP0004130_abnormal_muscle_cell1.52789847
68MP0005360_urolithiasis1.52158019
69MP0010094_abnormal_chromosome_stability1.50548602
70MP0002132_abnormal_respiratory_system1.47308974
71MP0005075_abnormal_melanosome_morpholog1.45859430
72MP0009278_abnormal_bone_marrow1.45637896
73MP0009333_abnormal_splenocyte_physiolog1.43130481
74MP0001485_abnormal_pinna_reflex1.41791645
75MP0009764_decreased_sensitivity_to1.41268111
76MP0004145_abnormal_muscle_electrophysio1.40056361
77MP0002006_tumorigenesis1.38783041
78MP0008877_abnormal_DNA_methylation1.37097697
79MP0002736_abnormal_nociception_after1.36400105
80MP0010386_abnormal_urinary_bladder1.35827203
81MP0009745_abnormal_behavioral_response1.35269522
82MP0001986_abnormal_taste_sensitivity1.32664527
83MP0001533_abnormal_skeleton_physiology1.31705591
84MP0008469_abnormal_protein_level1.29985701
85MP0002095_abnormal_skin_pigmentation1.28683816
86MP0000569_abnormal_digit_pigmentation1.28533202
87MP0000703_abnormal_thymus_morphology1.28485521
88MP0005253_abnormal_eye_physiology1.27078698
89MP0003866_abnormal_defecation1.26100108
90MP0005167_abnormal_blood-brain_barrier1.24922998
91MP0002735_abnormal_chemical_nociception1.24254630
92MP0000858_altered_metastatic_potential1.23203685
93MP0003186_abnormal_redox_activity1.22854406
94MP0006082_CNS_inflammation1.22584043
95MP0001851_eye_inflammation1.22502440
96MP0003879_abnormal_hair_cell1.21421160
97MP0003111_abnormal_nucleus_morphology1.20828970
98MP0002928_abnormal_bile_duct1.19856578
99MP0009379_abnormal_foot_pigmentation1.19675130
100MP0004381_abnormal_hair_follicle1.18516922
101MP0001486_abnormal_startle_reflex1.18172575
102MP0002102_abnormal_ear_morphology1.18164277
103MP0003077_abnormal_cell_cycle1.17322924
104MP0005266_abnormal_metabolism1.17011390
105MP0005409_darkened_coat_color1.14554002
106MP0004142_abnormal_muscle_tone1.13697105
107MP0000230_abnormal_systemic_arterial1.12291432
108MP0001664_abnormal_digestion1.10401248
109MP0003828_pulmonary_edema1.09942645
110MP0005395_other_phenotype1.08947223
111MP0003890_abnormal_embryonic-extraembry1.08498524
112MP0005377_hearing/vestibular/ear_phenot1.08385855
113MP0003878_abnormal_ear_physiology1.08385855
114MP0000470_abnormal_stomach_morphology1.07737625
115MP0000538_abnormal_urinary_bladder1.06891775
116MP0009697_abnormal_copulation1.06504206
117MP0001663_abnormal_digestive_system1.03521512
118MP0002933_joint_inflammation1.02865504
119MP0001764_abnormal_homeostasis1.02215371
120MP0002019_abnormal_tumor_incidence1.01874354
121MP0005171_absent_coat_pigmentation0.99805774
122MP0006276_abnormal_autonomic_nervous0.99685838
123MP0003300_gastrointestinal_ulcer0.99222630
124MP0005647_abnormal_sex_gland0.98310036
125MP0008007_abnormal_cellular_replicative0.97345472
126MP0002638_abnormal_pupillary_reflex0.96741135
127MP0004947_skin_inflammation0.96632157
128MP0002272_abnormal_nervous_system0.96387987
129MP0000343_altered_response_to0.96196025
130MP0005386_behavior/neurological_phenoty0.94231656
131MP0004924_abnormal_behavior0.94231656
132MP0000631_abnormal_neuroendocrine_gland0.93801892
133MP0009763_increased_sensitivity_to0.93716632
134MP0002229_neurodegeneration0.93436100
135MP0002067_abnormal_sensory_capabilities0.92796018
136MP0002009_preneoplasia0.91349006
137MP0005058_abnormal_lysosome_morphology0.90092609
138MP0001970_abnormal_pain_threshold0.89917380
139MP0002160_abnormal_reproductive_system0.89897666
140MP0010329_abnormal_lipoprotein_level0.89689127
141MP0006054_spinal_hemorrhage0.88138700
142MP0010678_abnormal_skin_adnexa0.88092218
143MP0004782_abnormal_surfactant_physiolog0.87828645
144MP0005220_abnormal_exocrine_pancreas0.86471098
145MP0002572_abnormal_emotion/affect_behav0.86373715
146MP0003183_abnormal_peptide_metabolism0.85882257
147MP0001879_abnormal_lymphatic_vessel0.85190022
148MP0002064_seizures0.84197517
149MP0005365_abnormal_bile_salt0.84194931
150MP0005389_reproductive_system_phenotype0.83597450
151MP0002733_abnormal_thermal_nociception0.82043566
152MP0001984_abnormal_olfaction0.81410982
153MP0002693_abnormal_pancreas_physiology0.81109918
154MP0001765_abnormal_ion_homeostasis0.80896989
155MP0002138_abnormal_hepatobiliary_system0.79898348
156MP0003172_abnormal_lysosome_physiology0.79363145
157MP0002139_abnormal_hepatobiliary_system0.78522690
158MP0005448_abnormal_energy_balance0.78075700
159MP0002557_abnormal_social/conspecific_i0.77084780
160MP0003633_abnormal_nervous_system0.76628292
161MP0002332_abnormal_exercise_endurance0.76171215
162MP0009115_abnormal_fat_cell0.75913691
163MP0000372_irregular_coat_pigmentation0.73935478
164MP0005083_abnormal_biliary_tract0.73696770
165MP0004957_abnormal_blastocyst_morpholog0.72554743
166MP0003786_premature_aging0.72309139
167MP0003656_abnormal_erythrocyte_physiolo0.69758273
168MP0008995_early_reproductive_senescence0.68690245
169MP0005085_abnormal_gallbladder_physiolo0.67038778
170MP0005408_hypopigmentation0.65782571
171MP0003448_altered_tumor_morphology0.65645703
172MP0000371_diluted_coat_color0.65151207
173MP0008875_abnormal_xenobiotic_pharmacok0.65062231
174MP0003943_abnormal_hepatobiliary_system0.64758796
175MP0005451_abnormal_body_composition0.64662869
176MP0003252_abnormal_bile_duct0.64538238
177MP0008260_abnormal_autophagy0.63367383

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.29767148
2Genetic anticipation (HP:0003743)5.27954095
3Eczematoid dermatitis (HP:0000976)5.20442005
4Pancreatic cysts (HP:0001737)4.79870389
5Recurrent bacterial skin infections (HP:0005406)4.49357629
6Thrombocytosis (HP:0001894)4.46136877
7Recurrent gram-negative bacterial infections (HP:0005420)4.28947255
8Hyperventilation (HP:0002883)4.21369558
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.17652006
10Obstructive lung disease (HP:0006536)4.08936644
11Chronic obstructive pulmonary disease (HP:0006510)4.08936644
12Gaze-evoked nystagmus (HP:0000640)4.07741058
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.05990686
14Pancreatic fibrosis (HP:0100732)4.03059974
15IgM deficiency (HP:0002850)3.98406079
16Progressive cerebellar ataxia (HP:0002073)3.98339973
17True hermaphroditism (HP:0010459)3.92979720
18Myositis (HP:0100614)3.66680219
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.64102857
20Absent/shortened dynein arms (HP:0200106)3.64102857
21Meningitis (HP:0001287)3.63483007
22Abnormality of the renal cortex (HP:0011035)3.58894407
23Congenital stationary night blindness (HP:0007642)3.58544718
24Recurrent fungal infections (HP:0002841)3.51635986
25Clumsiness (HP:0002312)3.44440273
26Cystic liver disease (HP:0006706)3.35161258
27Abnormality of midbrain morphology (HP:0002418)3.33841585
28Molar tooth sign on MRI (HP:0002419)3.33841585
29Chronic hepatic failure (HP:0100626)3.32843715
30Attenuation of retinal blood vessels (HP:0007843)3.31625486
31Abnormal ciliary motility (HP:0012262)3.29915892
32Reduced antithrombin III activity (HP:0001976)3.27013846
33Nephronophthisis (HP:0000090)3.24926586
34Mediastinal lymphadenopathy (HP:0100721)3.21788392
35Abnormality of the renal medulla (HP:0100957)3.19709451
36Recurrent skin infections (HP:0001581)3.18156902
37Prolonged bleeding time (HP:0003010)3.15421741
38Increased cerebral lipofuscin (HP:0011813)3.13179297
39Abnormality of macrophages (HP:0004311)3.12425377
40Aplastic anemia (HP:0001915)3.11476853
41Abnormality of the prostate (HP:0008775)3.08016713
42Stomatitis (HP:0010280)3.06730704
43Protruding tongue (HP:0010808)3.05022527
44Gingivitis (HP:0000230)3.04193747
45Elevated erythrocyte sedimentation rate (HP:0003565)3.03976096
46Abnormal delayed hypersensitivity skin test (HP:0002963)3.02529773
47Eosinophilia (HP:0001880)3.02296982
48Granulocytopenia (HP:0001913)3.01327638
49Spontaneous hematomas (HP:0007420)2.99436902
50Joint hemorrhage (HP:0005261)2.98893642
51Decreased circulating renin level (HP:0003351)2.98301250
52Abnormality of DNA repair (HP:0003254)2.97098098
53Reticulocytopenia (HP:0001896)2.95012503
54Abnormal respiratory motile cilium morphology (HP:0005938)2.94568317
55Abnormal respiratory epithelium morphology (HP:0012253)2.94568317
56Abnormality of T cell physiology (HP:0011840)2.91856427
57Abnormality of B cell number (HP:0010975)2.90337073
58B lymphocytopenia (HP:0010976)2.90337073
59Epistaxis (HP:0000421)2.88994527
60Abnormal respiratory motile cilium physiology (HP:0012261)2.87799838
61Petechiae (HP:0000967)2.86838439
62Recurrent viral infections (HP:0004429)2.82810291
63Poikiloderma (HP:0001029)2.81504869
64Periodontitis (HP:0000704)2.81278372
65Chronic otitis media (HP:0000389)2.80137467
66Cellulitis (HP:0100658)2.78407897
67Abolished electroretinogram (ERG) (HP:0000550)2.70573803
68Vasculitis (HP:0002633)2.70229979
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68111408
70Abnormality of T cells (HP:0002843)2.67951553
71Fair hair (HP:0002286)2.67763806
72Central scotoma (HP:0000603)2.67537425
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64994235
74Tubular atrophy (HP:0000092)2.64991561
75Chromsome breakage (HP:0040012)2.63262711
76Type I transferrin isoform profile (HP:0003642)2.61051292
77Recurrent cutaneous fungal infections (HP:0011370)2.55574699
78Chronic mucocutaneous candidiasis (HP:0002728)2.55574699
79Abnormal number of erythroid precursors (HP:0012131)2.55528430
80Febrile seizures (HP:0002373)2.54153502
81Panhypogammaglobulinemia (HP:0003139)2.52290811
82Abnormality of eosinophils (HP:0001879)2.51785422
83Rhinitis (HP:0012384)2.51454380
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.50673228
85Encephalitis (HP:0002383)2.48858763
86Recurrent sinusitis (HP:0011108)2.47347231
87Leukocytosis (HP:0001974)2.46745725
88Furrowed tongue (HP:0000221)2.42860980
89Lymphopenia (HP:0001888)2.42826708
90Congenital hepatic fibrosis (HP:0002612)2.42441865
91Abnormality of cells of the erythroid lineage (HP:0012130)2.42432640
92Orchitis (HP:0100796)2.42395039
93Medial flaring of the eyebrow (HP:0010747)2.42257285
94Gingival bleeding (HP:0000225)2.41777009
95Dysmetric saccades (HP:0000641)2.41090801
96Pustule (HP:0200039)2.40898408
97IgG deficiency (HP:0004315)2.40826488
98Pulmonary infiltrates (HP:0002113)2.40572920
99Cerebellar dysplasia (HP:0007033)2.40407282
100Hemoptysis (HP:0002105)2.40192548
101Optic neuritis (HP:0100653)2.38410810
102Retrobulbar optic neuritis (HP:0100654)2.38410810
103Entropion (HP:0000621)2.36646368
104Recurrent bronchitis (HP:0002837)2.35908318
105Bony spicule pigmentary retinopathy (HP:0007737)2.34728281
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.34120031
107Congenital sensorineural hearing impairment (HP:0008527)2.32997629
108Generalized hypopigmentation of hair (HP:0011358)2.32048386
109Vacuolated lymphocytes (HP:0001922)2.30702166
110Stomach cancer (HP:0012126)2.29358873
111Absent speech (HP:0001344)2.29342412
112Widely spaced teeth (HP:0000687)2.28886973
113Decreased central vision (HP:0007663)2.28287426
114Osteomyelitis (HP:0002754)2.27603975
115Chest pain (HP:0100749)2.27155594
116Abnormal drinking behavior (HP:0030082)2.27008404
117Polydipsia (HP:0001959)2.27008404
118Autoimmune thrombocytopenia (HP:0001973)2.26764145
119Neutropenia (HP:0001875)2.26138381
120Amelogenesis imperfecta (HP:0000705)2.25842295
121Type II lissencephaly (HP:0007260)2.20874452
122Urticaria (HP:0001025)2.20645724
123Recurrent pneumonia (HP:0006532)2.19679665
124Sepsis (HP:0100806)2.19573486
125Agammaglobulinemia (HP:0004432)2.18178010
126Large for gestational age (HP:0001520)2.18070808
127Skin ulcer (HP:0200042)2.17764395
128Abnormality of macular pigmentation (HP:0008002)2.17520969
129Abnormal platelet volume (HP:0011876)2.17483990
130Aplasia/Hypoplasia of the tongue (HP:0010295)2.15985113
131Bronchiectasis (HP:0002110)2.15026730
132Broad-based gait (HP:0002136)2.13616313
133Increased IgE level (HP:0003212)2.13600378
134Facial diplegia (HP:0001349)2.13444872
135Keratoconjunctivitis sicca (HP:0001097)2.13355370
136T lymphocytopenia (HP:0005403)2.12866325
137Myelodysplasia (HP:0002863)2.10719702
138Abnormality of T cell number (HP:0011839)2.10505381
139Inflammation of the large intestine (HP:0002037)2.09511125
140Hypergammaglobulinemia (HP:0010702)2.08452522
141Progressive inability to walk (HP:0002505)2.08397985
142Bile duct proliferation (HP:0001408)2.07819976
143Abnormal biliary tract physiology (HP:0012439)2.07819976
144Renal cortical cysts (HP:0000803)2.06051331
145Prolonged partial thromboplastin time (HP:0003645)2.05952060
146Lymphoma (HP:0002665)2.05858071
147Thoracic kyphosis (HP:0002942)2.04437055
148Gastrointestinal inflammation (HP:0004386)2.03910264
149Abnormality of pyrimidine metabolism (HP:0004353)2.03651719
150Pulmonary fibrosis (HP:0002206)2.03445399
151Gangrene (HP:0100758)2.02494396
152Inability to walk (HP:0002540)2.02101341
153Sclerocornea (HP:0000647)2.01673733
154Hypoplasia of the thymus (HP:0000778)2.01576336
155Hypochromic anemia (HP:0001931)2.01522166
156Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01499549
157Severe combined immunodeficiency (HP:0004430)2.01392794
158Chronic diarrhea (HP:0002028)2.00481727
159Microcytic anemia (HP:0001935)2.00431551
160Macular degeneration (HP:0000608)1.98203925
161Keratoconus (HP:0000563)1.97910442
162Increased corneal curvature (HP:0100692)1.97910442
163Albinism (HP:0001022)1.97755657
164Hepatosplenomegaly (HP:0001433)1.97737166
165Postaxial foot polydactyly (HP:0001830)1.95180464
166Abnormal protein glycosylation (HP:0012346)1.94749829
167Abnormal glycosylation (HP:0012345)1.94749829
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94749829
169Abnormal protein N-linked glycosylation (HP:0012347)1.94749829
170Impaired smooth pursuit (HP:0007772)1.93315392
171Dialeptic seizures (HP:0011146)1.93155955
172Abnormality of alanine metabolism (HP:0010916)1.92059906
173Hyperalaninemia (HP:0003348)1.92059906
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92059906
175Anencephaly (HP:0002323)1.90836806
176Gait imbalance (HP:0002141)1.89849273
177Male pseudohermaphroditism (HP:0000037)1.89835437
178Congenital primary aphakia (HP:0007707)1.88879367
179Scotoma (HP:0000575)1.88772606
180Tubulointerstitial nephritis (HP:0001970)1.87255348
181Hyperkalemia (HP:0002153)1.85498536
182Hypoplasia of the pons (HP:0012110)1.83383243
183Abnormality of the pons (HP:0007361)1.81573383
184Enlarged kidneys (HP:0000105)1.81549126
185Abnormal rod and cone electroretinograms (HP:0008323)1.78686282
186Clubbing of toes (HP:0100760)1.74842202
187Patellar aplasia (HP:0006443)1.74293644
188Abnormality of the renal collecting system (HP:0004742)1.73804641
189Nephrogenic diabetes insipidus (HP:0009806)1.73347859
190Tented upper lip vermilion (HP:0010804)1.73300902
191Polyuria (HP:0000103)1.73142178
192Constricted visual fields (HP:0001133)1.71922478
193Poor coordination (HP:0002370)1.70431573
194Abnormality of renin-angiotensin system (HP:0000847)1.70114301
195Highly arched eyebrow (HP:0002553)1.69345887
196Focal seizures (HP:0007359)1.68950082
197Diplopia (HP:0000651)1.67652911
198Abnormality of binocular vision (HP:0011514)1.67652911
199Tubulointerstitial abnormality (HP:0001969)1.66888274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.61649453
2MAP4K13.57349192
3IRAK43.45455264
4KIT3.24972389
5TXK3.10831700
6ADRBK22.88154099
7TEC2.64324077
8MAP2K32.41382773
9BLK2.38729854
10IRAK32.31915145
11BTK2.29602259
12INSRR2.16220247
13AKT32.11546734
14LATS11.95302617
15FLT31.91353533
16NME21.90941000
17ZAP701.87747023
18NLK1.75576846
19MAP3K121.72884218
20STK38L1.69918899
21MAP3K141.69006130
22CSF1R1.67472244
23TAOK31.65108259
24TGFBR11.64619929
25IKBKE1.62268322
26STK161.61420347
27JAK31.61193772
28TIE11.55938615
29OXSR11.55335311
30SYK1.54620165
31TYK21.41095819
32ACVR1B1.38708257
33ADRBK11.38433523
34GRK61.38417206
35KDR1.35339982
36CLK11.33493392
37EIF2AK31.25019087
38STK391.24793594
39DAPK21.24579893
40TBK11.22347174
41WEE11.21056703
42MAP3K31.18969284
43STK101.18131804
44FES1.16085228
45MAPK131.15815296
46MKNK11.15178265
47BMPR1B1.13509665
48SRPK11.13411825
49MAP4K21.10650044
50PIM11.10367537
51TNIK1.09066895
52TNK21.08210834
53HCK1.07836993
54ITK1.06395546
55WNK31.05200381
56FGFR41.04925032
57RIPK41.04406860
58LCK1.03976110
59CSK1.03854057
60PTK2B1.03415934
61LYN1.01964085
62MAP3K70.99984725
63CAMK1D0.98908371
64PIK3CA0.98694914
65PRKAA20.98546803
66MELK0.97880191
67CDK120.97320440
68WNK40.97233044
69EIF2AK20.97062297
70TRPM70.96329475
71NTRK30.94975405
72MAP3K40.94512467
73STK380.93704497
74IKBKB0.93317879
75MAPK150.92706520
76PIM20.90906525
77MKNK20.90499908
78PINK10.89699514
79NEK90.89298595
80STK40.87902440
81JAK10.87716956
82EEF2K0.87304720
83CASK0.85399915
84CAMK1G0.85295957
85MST40.85039049
86BRSK20.84708894
87EPHB10.84024357
88FER0.83356329
89YES10.82355342
90EPHA30.82329511
91IRAK10.81354456
92CDK70.80859425
93CDC70.79402119
94VRK10.77679310
95BUB10.73733090
96MAPKAPK30.72538231
97CHUK0.71043401
98CDK40.70715382
99RPS6KA40.70443358
100MAPK40.68117022
101SGK20.67737045
102DYRK30.67202619
103TGFBR20.67191611
104STK30.66661445
105PLK40.65903429
106TESK20.65501751
107RPS6KB20.63551198
108ERN10.63279084
109PRKCE0.62934364
110FGFR30.62233753
111OBSCN0.61137079
112PIK3CG0.60774852
113BRD40.59814862
114MYLK0.59504128
115PAK30.57315429
116WNK10.56129667
117TLK10.56093138
118CAMKK20.55696111
119ATR0.55667210
120NEK20.55255295
121MAP2K20.53769630
122MARK30.52902722
123RPS6KA60.52586011
124STK110.50935007
125RPS6KC10.50428973
126RPS6KL10.50428973
127ZAK0.50128225
128JAK20.50038364
129PRKAA10.49670128
130TSSK60.49254415
131LRRK20.48195969
132EIF2AK10.47232377
133NUAK10.46891936
134MAPK110.45931068
135CDK60.45552253
136SGK30.44860306
137ERBB20.44586892
138AURKB0.44537451
139MAP3K100.43915251
140GRK10.43470183
141MAP2K10.42961487
142SGK10.42570966
143PRKD20.42339796
144PRKCQ0.40597871
145CAMK10.40399207
146CAMK40.40073803
147BMPR20.39112110
148MAP2K60.38861089
149BCKDK0.36627838
150SGK4940.36454509
151SGK2230.36454509
152MAP3K20.36226720
153SIK20.34096049
154PDK10.32199051
155ABL10.30087611
156GRK70.29024854
157PRKACA0.28786061
158CSNK1D0.28714459
159RPS6KA50.28258291
160CAMK2A0.28179481

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.90111618
2DNA replication_Homo sapiens_hsa030302.73448219
3Linoleic acid metabolism_Homo sapiens_hsa005912.51010857
4Ribosome_Homo sapiens_hsa030102.44109151
5Leishmaniasis_Homo sapiens_hsa051402.25470581
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25235786
7Tryptophan metabolism_Homo sapiens_hsa003802.20665190
8Phototransduction_Homo sapiens_hsa047442.20458465
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.20342651
10Nitrogen metabolism_Homo sapiens_hsa009102.12890934
11Butanoate metabolism_Homo sapiens_hsa006502.09621893
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08779614
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04226661
14Non-homologous end-joining_Homo sapiens_hsa034502.01927603
15Hematopoietic cell lineage_Homo sapiens_hsa046401.97978282
16Base excision repair_Homo sapiens_hsa034101.96662926
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85742184
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.85630542
19Homologous recombination_Homo sapiens_hsa034401.83255394
20Staphylococcus aureus infection_Homo sapiens_hsa051501.82224306
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81352372
22Taste transduction_Homo sapiens_hsa047421.79475701
23Measles_Homo sapiens_hsa051621.68471108
24Nicotine addiction_Homo sapiens_hsa050331.68042427
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63699093
26Mismatch repair_Homo sapiens_hsa034301.62338302
27Fanconi anemia pathway_Homo sapiens_hsa034601.58906760
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57347913
29Ether lipid metabolism_Homo sapiens_hsa005651.56564595
30Caffeine metabolism_Homo sapiens_hsa002321.56562661
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55091537
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54816493
33Herpes simplex infection_Homo sapiens_hsa051681.51025859
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.46724904
35Pyrimidine metabolism_Homo sapiens_hsa002401.46408303
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43083599
37B cell receptor signaling pathway_Homo sapiens_hsa046621.42409564
38Morphine addiction_Homo sapiens_hsa050321.34824957
39One carbon pool by folate_Homo sapiens_hsa006701.32822261
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32717995
41RNA polymerase_Homo sapiens_hsa030201.32678166
42Osteoclast differentiation_Homo sapiens_hsa043801.30992788
43Lysine degradation_Homo sapiens_hsa003101.29736948
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.29456284
45Nucleotide excision repair_Homo sapiens_hsa034201.27638311
46Glycerolipid metabolism_Homo sapiens_hsa005611.27164058
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26688751
48Other glycan degradation_Homo sapiens_hsa005111.26123887
49Ovarian steroidogenesis_Homo sapiens_hsa049131.24389356
50Histidine metabolism_Homo sapiens_hsa003401.23530574
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23373625
52Pentose phosphate pathway_Homo sapiens_hsa000301.22418183
53Olfactory transduction_Homo sapiens_hsa047401.21861892
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21588915
55Spliceosome_Homo sapiens_hsa030401.21336033
56Dorso-ventral axis formation_Homo sapiens_hsa043201.20210462
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.17958023
58Legionellosis_Homo sapiens_hsa051341.17881964
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.16810516
60Allograft rejection_Homo sapiens_hsa053301.16722245
61Calcium signaling pathway_Homo sapiens_hsa040201.14858325
62Serotonergic synapse_Homo sapiens_hsa047261.13927848
63Salivary secretion_Homo sapiens_hsa049701.13554581
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12786775
65Complement and coagulation cascades_Homo sapiens_hsa046101.11351243
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11157656
67Antigen processing and presentation_Homo sapiens_hsa046121.10297987
68Vascular smooth muscle contraction_Homo sapiens_hsa042701.08675211
69Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07352132
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03936850
71Sphingolipid metabolism_Homo sapiens_hsa006001.03840140
72Cell cycle_Homo sapiens_hsa041101.03400682
73Acute myeloid leukemia_Homo sapiens_hsa052211.03000354
74Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01832849
75Selenocompound metabolism_Homo sapiens_hsa004501.01700768
76Protein export_Homo sapiens_hsa030601.00822953
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00671679
78Asthma_Homo sapiens_hsa053100.99958395
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.99360258
80Circadian entrainment_Homo sapiens_hsa047130.98960202
81Pertussis_Homo sapiens_hsa051330.98010755
82Glutamatergic synapse_Homo sapiens_hsa047240.97050792
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96976568
84Malaria_Homo sapiens_hsa051440.95738880
85p53 signaling pathway_Homo sapiens_hsa041150.95171424
86Tuberculosis_Homo sapiens_hsa051520.90088358
87beta-Alanine metabolism_Homo sapiens_hsa004100.87941525
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87175650
89Fatty acid biosynthesis_Homo sapiens_hsa000610.86823919
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85893311
91Influenza A_Homo sapiens_hsa051640.85415405
92RNA degradation_Homo sapiens_hsa030180.84933858
93T cell receptor signaling pathway_Homo sapiens_hsa046600.84909261
94Graft-versus-host disease_Homo sapiens_hsa053320.81082070
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.80676070
96GABAergic synapse_Homo sapiens_hsa047270.77312683
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77174177
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76402827
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75049042
100Hepatitis B_Homo sapiens_hsa051610.73922096
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.73776470
102Glutathione metabolism_Homo sapiens_hsa004800.73249953
103Folate biosynthesis_Homo sapiens_hsa007900.72505749
104Chemical carcinogenesis_Homo sapiens_hsa052040.71617558
105Toxoplasmosis_Homo sapiens_hsa051450.71313407
106Starch and sucrose metabolism_Homo sapiens_hsa005000.71236842
107Platelet activation_Homo sapiens_hsa046110.71209380
108Cholinergic synapse_Homo sapiens_hsa047250.70720491
109Type II diabetes mellitus_Homo sapiens_hsa049300.70680755
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69625203
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69592803
112Type I diabetes mellitus_Homo sapiens_hsa049400.69406129
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69255710
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69254361
115Insulin secretion_Homo sapiens_hsa049110.69198900
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68663263
117Systemic lupus erythematosus_Homo sapiens_hsa053220.68576910
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68462477
119Peroxisome_Homo sapiens_hsa041460.68429680
120Epstein-Barr virus infection_Homo sapiens_hsa051690.68136029
121Autoimmune thyroid disease_Homo sapiens_hsa053200.67252146
122TNF signaling pathway_Homo sapiens_hsa046680.66513340
123Apoptosis_Homo sapiens_hsa042100.65947289
124Shigellosis_Homo sapiens_hsa051310.65547398
125Fatty acid degradation_Homo sapiens_hsa000710.64863989
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.64857390
127Basal transcription factors_Homo sapiens_hsa030220.64382490
128Pancreatic secretion_Homo sapiens_hsa049720.64322569
129Purine metabolism_Homo sapiens_hsa002300.62728835
130Chemokine signaling pathway_Homo sapiens_hsa040620.62679078
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62158790
132Circadian rhythm_Homo sapiens_hsa047100.61245918
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60983486
134N-Glycan biosynthesis_Homo sapiens_hsa005100.60723673
135Vitamin digestion and absorption_Homo sapiens_hsa049770.60513840
136Arachidonic acid metabolism_Homo sapiens_hsa005900.60495987
137ABC transporters_Homo sapiens_hsa020100.59672683
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59409711
139Renin secretion_Homo sapiens_hsa049240.58684993
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58660472
141Hepatitis C_Homo sapiens_hsa051600.58474387
142Oxytocin signaling pathway_Homo sapiens_hsa049210.58366583
143Gastric acid secretion_Homo sapiens_hsa049710.56227177
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55532570
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55255435
146Bile secretion_Homo sapiens_hsa049760.55033266
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.54645666
148cAMP signaling pathway_Homo sapiens_hsa040240.54612888
149Retinol metabolism_Homo sapiens_hsa008300.53844469
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52475007
151Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51995956
152Viral myocarditis_Homo sapiens_hsa054160.51788797
153Proteasome_Homo sapiens_hsa030500.50743168
154Long-term depression_Homo sapiens_hsa047300.49557378
155Regulation of autophagy_Homo sapiens_hsa041400.47522506
156Propanoate metabolism_Homo sapiens_hsa006400.44149992
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39533250
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38866493
159FoxO signaling pathway_Homo sapiens_hsa040680.35294631
160Mineral absorption_Homo sapiens_hsa049780.35078794
161Insulin resistance_Homo sapiens_hsa049310.35037072
162Fat digestion and absorption_Homo sapiens_hsa049750.34807785

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