CCDC126

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eye photoreceptor cell development (GO:0042462)9.93515138
2retinal rod cell development (GO:0046548)9.00788660
3detection of light stimulus involved in visual perception (GO:0050908)7.96838887
4detection of light stimulus involved in sensory perception (GO:0050962)7.96838887
5phototransduction, visible light (GO:0007603)7.32665673
6phototransduction (GO:0007602)7.32164362
7detection of visible light (GO:0009584)7.10399127
8detection of light stimulus (GO:0009583)7.05197466
9eye photoreceptor cell differentiation (GO:0001754)6.83297590
10photoreceptor cell differentiation (GO:0046530)6.83297590
11visual perception (GO:0007601)6.67148015
12positive regulation of guanylate cyclase activity (GO:0031284)6.61338551
13sensory perception of light stimulus (GO:0050953)6.60977509
14nonmotile primary cilium assembly (GO:0035058)6.22465571
15regulation of guanylate cyclase activity (GO:0031282)6.22159307
16cellular response to light stimulus (GO:0071482)5.73888157
17protein-chromophore linkage (GO:0018298)5.48798426
18response to pheromone (GO:0019236)5.30170925
19detection of external stimulus (GO:0009581)5.11439569
20retina development in camera-type eye (GO:0060041)5.10442841
21detection of abiotic stimulus (GO:0009582)5.04772715
22regulation of cGMP metabolic process (GO:0030823)4.99511654
23DNA double-strand break processing (GO:0000729)4.26785346
24water-soluble vitamin biosynthetic process (GO:0042364)4.12189929
25positive regulation of cGMP biosynthetic process (GO:0030828)4.08511465
26axoneme assembly (GO:0035082)4.01693512
27regulation of cGMP biosynthetic process (GO:0030826)3.98614542
28CDP-diacylglycerol metabolic process (GO:0046341)3.92150457
29retina layer formation (GO:0010842)3.90302867
30inositol phosphate catabolic process (GO:0071545)3.89054104
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87880356
32regulation of glucokinase activity (GO:0033131)3.83447360
33regulation of hexokinase activity (GO:1903299)3.83447360
34heme transport (GO:0015886)3.82742037
35positive regulation of cGMP metabolic process (GO:0030825)3.81684270
36positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.78385971
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.78385971
38piRNA metabolic process (GO:0034587)3.75581677
39receptor guanylyl cyclase signaling pathway (GO:0007168)3.75254345
40prenylation (GO:0097354)3.73761122
41protein prenylation (GO:0018342)3.73761122
42protein K6-linked ubiquitination (GO:0085020)3.70103151
43xenobiotic catabolic process (GO:0042178)3.63344747
44cellular potassium ion homeostasis (GO:0030007)3.62597924
45CDP-diacylglycerol biosynthetic process (GO:0016024)3.62100959
46regulation of voltage-gated calcium channel activity (GO:1901385)3.57914175
47cellular response to radiation (GO:0071478)3.56543925
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55507449
49positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.51708326
50regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.49014745
51platelet dense granule organization (GO:0060155)3.48418222
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48303241
53sensory perception (GO:0007600)3.47376325
54inositol phosphate dephosphorylation (GO:0046855)3.44700542
55phosphorylated carbohydrate dephosphorylation (GO:0046838)3.44700542
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.42952708
57mitochondrion transport along microtubule (GO:0047497)3.42952708
58keratinocyte development (GO:0003334)3.42472839
59proteasome assembly (GO:0043248)3.42046963
60cell morphogenesis involved in neuron differentiation (GO:0048667)3.41723408
61adaptation of signaling pathway (GO:0023058)3.40724087
62protein K11-linked deubiquitination (GO:0035871)3.40038441
63polyol catabolic process (GO:0046174)3.34993807
64C4-dicarboxylate transport (GO:0015740)3.33495774
65GPI anchor metabolic process (GO:0006505)3.31947208
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.25990953
67sensory perception of smell (GO:0007608)3.25028932
68mitochondrial DNA replication (GO:0006264)3.23532745
69cellular ketone body metabolic process (GO:0046950)3.23032353
70regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.21438400
71regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.21438400
72preassembly of GPI anchor in ER membrane (GO:0016254)3.20589233
73positive regulation of sodium ion transmembrane transport (GO:1902307)3.20295284
74GPI anchor biosynthetic process (GO:0006506)3.18654656
75negative regulation of cation channel activity (GO:2001258)3.17894542
76positive regulation of meiosis (GO:0045836)3.15674566
77regulation of acyl-CoA biosynthetic process (GO:0050812)3.15368696
78nucleotide transmembrane transport (GO:1901679)3.15344377
79branched-chain amino acid catabolic process (GO:0009083)3.12230621
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.12206125
81protein localization to synapse (GO:0035418)3.10096980
82establishment of mitochondrion localization (GO:0051654)3.09087662
83dopamine transport (GO:0015872)3.08967216
84regulation of meiosis I (GO:0060631)3.08578517
85regulation of sulfur metabolic process (GO:0042762)3.06681486
86positive regulation of meiotic cell cycle (GO:0051446)3.05388649
87negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04548969
88regulation of acrosome reaction (GO:0060046)3.00850736
89establishment of protein localization to mitochondrial membrane (GO:0090151)3.00809822
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00565599
91neuron development (GO:0048666)2.98864776
92positive regulation of mitochondrial membrane permeability (GO:0035794)2.96233400
93cullin deneddylation (GO:0010388)2.95838663
94ketone body metabolic process (GO:1902224)2.92011214
95anterograde synaptic vesicle transport (GO:0048490)2.91466026
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89523674
97sodium ion export (GO:0071436)2.88548616
98striatum development (GO:0021756)2.88358951
99protein targeting to Golgi (GO:0000042)2.88332401
100negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.87483176
101respiratory chain complex IV assembly (GO:0008535)2.86349119
102mannosylation (GO:0097502)2.85983496
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.84930024
104establishment of protein localization to Golgi (GO:0072600)2.84298350
105regulation of coenzyme metabolic process (GO:0051196)2.84291318
106regulation of cofactor metabolic process (GO:0051193)2.84291318
107startle response (GO:0001964)2.83188749
108C-terminal protein lipidation (GO:0006501)2.82251136
109negative regulation of neurological system process (GO:0031645)2.81266172
110lactate metabolic process (GO:0006089)2.80490868
111regulation of cilium movement (GO:0003352)2.79723512
112response to light stimulus (GO:0009416)2.79681701
113indolalkylamine metabolic process (GO:0006586)2.79676887
114protein complex biogenesis (GO:0070271)2.77079606
115adenosine metabolic process (GO:0046085)2.76654908
116synaptic vesicle exocytosis (GO:0016079)2.75341746
117potassium ion homeostasis (GO:0055075)2.73627194
118DNA methylation involved in gamete generation (GO:0043046)2.72779031
119signal peptide processing (GO:0006465)2.72743818
120short-chain fatty acid metabolic process (GO:0046459)2.72291243
121estrogen biosynthetic process (GO:0006703)2.71547186
122negative regulation of protein oligomerization (GO:0032460)2.70362855
123neural tube formation (GO:0001841)2.70235389
124C-terminal protein amino acid modification (GO:0018410)2.70117700
125protein-cofactor linkage (GO:0018065)2.69655828
126short-term memory (GO:0007614)2.68937379
127protein deneddylation (GO:0000338)2.67794291
128intra-Golgi vesicle-mediated transport (GO:0006891)2.66062521
129response to histamine (GO:0034776)2.65054173
130regulation of clathrin-mediated endocytosis (GO:2000369)2.63376717
131iron coordination entity transport (GO:1901678)2.60589169
132ATP hydrolysis coupled proton transport (GO:0015991)2.59891810
133energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59891810
134sensory perception of chemical stimulus (GO:0007606)2.59561628
135glycolipid biosynthetic process (GO:0009247)2.59280687
136retina homeostasis (GO:0001895)2.58393104
137cell communication by electrical coupling (GO:0010644)2.57062634
138DNA deamination (GO:0045006)2.57041796
139melanosome transport (GO:0032402)2.56743473
140protein K11-linked ubiquitination (GO:0070979)2.56651537
141histone H2A ubiquitination (GO:0033522)2.56620591
142single strand break repair (GO:0000012)2.56200735
143melanosome localization (GO:0032400)2.54865748
144male meiosis (GO:0007140)2.54832123
145spermatid nucleus differentiation (GO:0007289)2.54700796
146positive regulation of glycoprotein biosynthetic process (GO:0010560)2.52494996
147cytochrome complex assembly (GO:0017004)2.51279293
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51064438
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50415858
150tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50415858
151protein localization to cilium (GO:0061512)2.49656412
152regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.49450769
153mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.48025658
154intraciliary transport (GO:0042073)2.47838918
155establishment of melanosome localization (GO:0032401)2.47761316
156DNA integration (GO:0015074)2.47670512
157intestinal epithelial cell development (GO:0060576)2.47250103
158epithelial cilium movement (GO:0003351)2.47246559
159regulation of synaptic transmission, dopaminergic (GO:0032225)2.47244316
160synapsis (GO:0007129)2.46111149
161somite rostral/caudal axis specification (GO:0032525)2.45915403
162somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.45592613
163somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.45592613
164isotype switching (GO:0045190)2.45592613
165retrograde transport, vesicle recycling within Golgi (GO:0000301)2.45369479
166histone H2A acetylation (GO:0043968)2.45152525
167regulation of synaptic vesicle exocytosis (GO:2000300)2.44965970
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44622265
169mitochondrial respiratory chain complex assembly (GO:0033108)2.43511192
170cilium morphogenesis (GO:0060271)2.43444063
171protein neddylation (GO:0045116)2.42675244
172arachidonic acid secretion (GO:0050482)2.42495722
173icosanoid secretion (GO:0032309)2.42495722
174regulation of feeding behavior (GO:0060259)2.42237595
175righting reflex (GO:0060013)2.41766315
176prostate gland growth (GO:0060736)2.41651182
177positive regulation of sodium ion transport (GO:0010765)2.41220792
178synaptic vesicle docking involved in exocytosis (GO:0016081)2.40453482
179negative regulation of Rho protein signal transduction (GO:0035024)2.38711446
180nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38641102
181pigment granule localization (GO:0051875)2.38332695
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.38079420
183neuron fate determination (GO:0048664)2.38017406
184pigment granule transport (GO:0051904)2.37759139
185lipid particle organization (GO:0034389)2.37348124
186positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.37331993
187gamma-aminobutyric acid signaling pathway (GO:0007214)2.35994905
188negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.34165338
189negative regulation of calcium ion transmembrane transport (GO:1903170)2.34165338
190adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.32221736
191regulation of penile erection (GO:0060405)2.31976524
192glutamate secretion (GO:0014047)2.31591036
193regulation of rhodopsin mediated signaling pathway (GO:0022400)14.1893865
194rhodopsin mediated signaling pathway (GO:0016056)13.8321563
195photoreceptor cell development (GO:0042461)10.4242520
196GMP metabolic process (GO:0046037)10.3430076
197retinal cone cell development (GO:0046549)10.2756079
198photoreceptor cell maintenance (GO:0045494)10.2066316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.66180759
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.63367568
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71482131
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.00883695
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89112539
6ZNF274_21170338_ChIP-Seq_K562_Hela2.87146269
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81754536
8IGF1R_20145208_ChIP-Seq_DFB_Human2.78527580
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.71872724
10VDR_22108803_ChIP-Seq_LS180_Human2.64028976
11GBX2_23144817_ChIP-Seq_PC3_Human2.47975467
12FUS_26573619_Chip-Seq_HEK293_Human2.31611095
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30812238
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16702036
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16310794
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05892051
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05248464
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03667807
19EWS_26573619_Chip-Seq_HEK293_Human2.03400004
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01788710
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87832244
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.86841462
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79564460
24FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.72419435
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69469801
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68322536
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64815335
28VDR_23849224_ChIP-Seq_CD4+_Human1.61596436
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60955821
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60911458
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.56731435
32REST_21632747_ChIP-Seq_MESCs_Mouse1.56028950
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55401673
34BCAT_22108803_ChIP-Seq_LS180_Human1.53672077
35CBP_20019798_ChIP-Seq_JUKART_Human1.52982705
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52982705
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52749079
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48747857
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48166547
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43974568
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42719111
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42133881
43IRF1_19129219_ChIP-ChIP_H3396_Human1.41725981
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.40954453
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.39938520
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39802702
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.37470165
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37463837
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37152716
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37057375
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36443653
52SMAD4_21799915_ChIP-Seq_A2780_Human1.35601504
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33648430
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33038657
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32552412
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31865558
57P300_19829295_ChIP-Seq_ESCs_Human1.31422530
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.29809973
59TP53_22573176_ChIP-Seq_HFKS_Human1.29072204
60ER_23166858_ChIP-Seq_MCF-7_Human1.28787777
61TCF4_22108803_ChIP-Seq_LS180_Human1.27760094
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.26534451
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25980395
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25473716
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.25180375
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24025040
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21673243
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21432225
69* TCF4_23295773_ChIP-Seq_U87_Human1.20835229
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19169463
71* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18683901
72P53_22387025_ChIP-Seq_ESCs_Mouse1.17817565
73CDX2_22108803_ChIP-Seq_LS180_Human1.17337541
74TAF15_26573619_Chip-Seq_HEK293_Human1.17009107
75* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16826921
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16672974
77MYC_18940864_ChIP-ChIP_HL60_Human1.16528895
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16207809
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15863834
80SALL4_22934838_ChIP-ChIP_CD34+_Human1.15270599
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.15219542
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15008917
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.13320036
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.13219661
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13037484
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12651764
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12599837
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12125939
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.11069057
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.11008772
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10981417
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10820176
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10203965
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07997273
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.07228096
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05686195
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04518376
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.04400853
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04224118
100P300_18555785_Chip-Seq_ESCs_Mouse1.03330203
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03093976
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02808624
103NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02533572
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02159207
105CTCF_20526341_ChIP-Seq_ESCs_Human1.02144184
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.01890336
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01578962
108STAT3_23295773_ChIP-Seq_U87_Human1.01427922
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01422771
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.01093060
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00447243
112AR_25329375_ChIP-Seq_VCAP_Human1.00267326
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99348464
114* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98976661
115NCOR_22424771_ChIP-Seq_293T_Human0.97641378
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96978876
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.94327827
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94103967
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.94103967
120TAF2_19829295_ChIP-Seq_ESCs_Human0.93920731
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93814386
122HTT_18923047_ChIP-ChIP_STHdh_Human0.92629292
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92621121
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.91503103
125ERG_20517297_ChIP-Seq_VCAP_Human0.90875170
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90855388
127EOMES_21245162_ChIP-Seq_HESCs_Human0.90523003
128TBL1_22424771_ChIP-Seq_293T_Human0.88383812
129SMAD4_21741376_ChIP-Seq_ESCs_Human0.87756330
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87685764
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86601845
132RNF2_27304074_Chip-Seq_NSC_Mouse0.86522847
133* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85097426
134RBPJ_21746931_ChIP-Seq_IB4_Human0.85000932
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.84965148
136ELK1_19687146_ChIP-ChIP_HELA_Human0.84484178
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83574788
138NANOG_16518401_ChIP-PET_MESCs_Mouse0.83396693
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83332207
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81862073
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80947132
142AR_20517297_ChIP-Seq_VCAP_Human0.80717980
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.80504521
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80307700
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.80238942
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80141792
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79685502
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79515900
149RUNX2_22187159_ChIP-Seq_PCA_Human0.78677663
150TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78589496
151GF1_26923725_Chip-Seq_HPCs_Mouse0.77848202
152NANOG_19829295_ChIP-Seq_ESCs_Human0.77606236
153SOX2_19829295_ChIP-Seq_ESCs_Human0.77606236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog8.61824668
2MP0003011_delayed_dark_adaptation7.52985031
3MP0006072_abnormal_retinal_apoptosis5.97318764
4MP0005253_abnormal_eye_physiology5.72010671
5MP0003950_abnormal_plasma_membrane4.91609788
6MP0003195_calcinosis4.89727684
7MP0010234_abnormal_vibrissa_follicle3.97520900
8MP0003787_abnormal_imprinting3.77074854
9MP0005195_abnormal_posterior_eye3.35428969
10MP0000569_abnormal_digit_pigmentation3.32540394
11MP0002638_abnormal_pupillary_reflex3.21845249
12MP0001324_abnormal_eye_pigmentation2.95723231
13MP0005391_vision/eye_phenotype2.71413630
14MP0005084_abnormal_gallbladder_morpholo2.60520257
15MP0002102_abnormal_ear_morphology2.51793597
16MP0001986_abnormal_taste_sensitivity2.36874852
17MP0006054_spinal_hemorrhage2.36380774
18MP0002229_neurodegeneration2.34000332
19MP0002090_abnormal_vision2.22474640
20MP0005423_abnormal_somatic_nervous2.17139350
21MP0001764_abnormal_homeostasis2.16552516
22MP0002909_abnormal_adrenal_gland2.16007113
23MP0002837_dystrophic_cardiac_calcinosis2.10817905
24MP0001529_abnormal_vocalization2.08634140
25MP0001984_abnormal_olfaction2.03171317
26MP0004270_analgesia1.96654347
27MP0003121_genomic_imprinting1.95213494
28MP0002653_abnormal_ependyma_morphology1.88374901
29MP0002928_abnormal_bile_duct1.81080837
30MP0009697_abnormal_copulation1.78251971
31MP0002734_abnormal_mechanical_nocicepti1.77661626
32MP0002752_abnormal_somatic_nervous1.74244602
33MP0002163_abnormal_gland_morphology1.73305595
34MP0003122_maternal_imprinting1.68809231
35MP0004885_abnormal_endolymph1.65349090
36MP0003724_increased_susceptibility_to1.65232333
37MP0006292_abnormal_olfactory_placode1.65071951
38MP0005645_abnormal_hypothalamus_physiol1.64101009
39MP0005646_abnormal_pituitary_gland1.61242474
40MP0001502_abnormal_circadian_rhythm1.59845109
41MP0010678_abnormal_skin_adnexa1.57807108
42MP0000427_abnormal_hair_cycle1.57231426
43MP0003136_yellow_coat_color1.55642982
44MP0004215_abnormal_myocardial_fiber1.55005756
45MP0005379_endocrine/exocrine_gland_phen1.52495323
46MP0008058_abnormal_DNA_repair1.50532990
47MP0003186_abnormal_redox_activity1.45565442
48MP0005408_hypopigmentation1.45485264
49MP0005075_abnormal_melanosome_morpholog1.43055881
50MP0003252_abnormal_bile_duct1.42634278
51MP0003786_premature_aging1.40118178
52MP0006035_abnormal_mitochondrial_morpho1.37540612
53MP0009046_muscle_twitch1.36860779
54MP0005174_abnormal_tail_pigmentation1.36807437
55MP0001542_abnormal_bone_strength1.36075661
56MP0006036_abnormal_mitochondrial_physio1.33449197
57MP0002882_abnormal_neuron_morphology1.29733265
58MP0006276_abnormal_autonomic_nervous1.25993674
59MP0002938_white_spotting1.25183061
60MP0005187_abnormal_penis_morphology1.22349983
61MP0000516_abnormal_urinary_system1.22283759
62MP0005367_renal/urinary_system_phenotyp1.22283759
63MP0004147_increased_porphyrin_level1.21815305
64MP0000015_abnormal_ear_pigmentation1.21621653
65MP0003634_abnormal_glial_cell1.19715001
66MP0002127_abnormal_cardiovascular_syste1.18580622
67MP0000647_abnormal_sebaceous_gland1.17514416
68MP0004142_abnormal_muscle_tone1.17498797
69MP0004742_abnormal_vestibular_system1.15628622
70MP0000372_irregular_coat_pigmentation1.13796625
71MP0002735_abnormal_chemical_nociception1.13795311
72MP0005410_abnormal_fertilization1.13183690
73MP0002272_abnormal_nervous_system1.13022239
74MP0001486_abnormal_startle_reflex1.11865252
75MP0003283_abnormal_digestive_organ1.10872908
76MP0004233_abnormal_muscle_weight1.09537266
77MP0004484_altered_response_of1.09267811
78MP0005670_abnormal_white_adipose1.09247911
79MP0000013_abnormal_adipose_tissue1.08160258
80MP0002277_abnormal_respiratory_mucosa1.06605560
81MP0001963_abnormal_hearing_physiology1.05736324
82MP0005636_abnormal_mineral_homeostasis1.05536695
83MP0001929_abnormal_gametogenesis0.99265450
84MP0008995_early_reproductive_senescence0.97956586
85MP0008875_abnormal_xenobiotic_pharmacok0.97930350
86MP0009780_abnormal_chondrocyte_physiolo0.97921406
87MP0001485_abnormal_pinna_reflex0.97601232
88MP0000639_abnormal_adrenal_gland0.97381757
89MP0002064_seizures0.97236716
90MP0004859_abnormal_synaptic_plasticity0.96168703
91MP0005409_darkened_coat_color0.95317895
92MP0001968_abnormal_touch/_nociception0.94879821
93MP0005171_absent_coat_pigmentation0.93456366
94MP0002693_abnormal_pancreas_physiology0.92291358
95MP0008872_abnormal_physiological_respon0.91484486
96MP0001501_abnormal_sleep_pattern0.90987510
97MP0003635_abnormal_synaptic_transmissio0.90758232
98MP0002751_abnormal_autonomic_nervous0.90519982
99MP0005085_abnormal_gallbladder_physiolo0.90449135
100MP0001970_abnormal_pain_threshold0.89435695
101MP0002736_abnormal_nociception_after0.87711552
102MP0003279_aneurysm0.87679561
103MP0005395_other_phenotype0.87676965
104MP0003698_abnormal_male_reproductive0.87365296
105MP0002160_abnormal_reproductive_system0.87008318
106MP0005389_reproductive_system_phenotype0.86947367
107MP0005451_abnormal_body_composition0.86094890
108MP0002009_preneoplasia0.85614683
109MP0005332_abnormal_amino_acid0.82712257
110MP0008260_abnormal_autophagy0.82681659
111MP0001944_abnormal_pancreas_morphology0.82021970
112MP0009384_cardiac_valve_regurgitation0.81108320
113MP0000653_abnormal_sex_gland0.80324452
114MP0004043_abnormal_pH_regulation0.79731809
115MP0002332_abnormal_exercise_endurance0.78775597
116MP0003119_abnormal_digestive_system0.78384625
117MP0010329_abnormal_lipoprotein_level0.77805793
118MP0002063_abnormal_learning/memory/cond0.77653757
119MP0003183_abnormal_peptide_metabolism0.77633468
120MP0000358_abnormal_cell_content/0.76979434
121MP0005197_abnormal_uvea_morphology0.76556419
122MP0002572_abnormal_emotion/affect_behav0.75998415
123MP0001905_abnormal_dopamine_level0.74363136
124MP0003880_abnormal_central_pattern0.73724736
125MP0002067_abnormal_sensory_capabilities0.72786477
126MP0002876_abnormal_thyroid_physiology0.71979118
127MP0008004_abnormal_stomach_pH0.71311640
128MP0002095_abnormal_skin_pigmentation0.70357818
129MP0002210_abnormal_sex_determination0.70326706
130MP0000383_abnormal_hair_follicle0.69315165
131MP0003879_abnormal_hair_cell0.68959943
132MP0005248_abnormal_Harderian_gland0.68909098
133MP0008789_abnormal_olfactory_epithelium0.68790436
134MP0005499_abnormal_olfactory_system0.68569653
135MP0005394_taste/olfaction_phenotype0.68569653
136MP0002877_abnormal_melanocyte_morpholog0.67237511
137MP0001440_abnormal_grooming_behavior0.62762523
138MP0001661_extended_life_span0.62531125
139MP0003329_amyloid_beta_deposits0.62148273
140MP0009840_abnormal_foam_cell0.60686074
141MP0003718_maternal_effect0.60469958
142MP0000465_gastrointestinal_hemorrhage0.59977241
143MP0000026_abnormal_inner_ear0.59455198
144MP0004019_abnormal_vitamin_homeostasis0.58938758
145MP0009745_abnormal_behavioral_response0.58895055
146MP0005595_abnormal_vascular_smooth0.58799881
147MP0003646_muscle_fatigue0.57308231
148MP0001177_atelectasis0.57223365
149MP0004085_abnormal_heartbeat0.56839166
150MP0002089_abnormal_postnatal_growth/wei0.56818789
151MP0002733_abnormal_thermal_nociception0.56052397
152MP0005377_hearing/vestibular/ear_phenot0.55138633
153MP0003878_abnormal_ear_physiology0.55138633
154MP0004036_abnormal_muscle_relaxation0.53208617
155MP0010386_abnormal_urinary_bladder0.52662317
156MP0004084_abnormal_cardiac_muscle0.51251084
157MP0003693_abnormal_embryo_hatching0.49288325
158MP0000428_abnormal_craniofacial_morphol0.49246237
159MP0003137_abnormal_impulse_conducting0.48777745
160MP0003123_paternal_imprinting0.47935881
161MP0002184_abnormal_innervation0.47489519
162MP0003690_abnormal_glial_cell0.46227445
163MP0008877_abnormal_DNA_methylation0.45595719
164MP0000631_abnormal_neuroendocrine_gland0.43069420
165MP0005620_abnormal_muscle_contractility0.42855666
166MP0002066_abnormal_motor_capabilities/c0.42754871
167MP0004858_abnormal_nervous_system0.41973596
168MP0005386_behavior/neurological_phenoty0.39974792
169MP0004924_abnormal_behavior0.39974792
170MP0005376_homeostasis/metabolism_phenot0.39380298
171MP0008007_abnormal_cellular_replicative0.35898055

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.83311596
2Chorioretinal atrophy (HP:0000533)8.37140087
3Pigmentary retinal degeneration (HP:0001146)7.49154141
4Attenuation of retinal blood vessels (HP:0007843)7.36122925
5Central scotoma (HP:0000603)6.80448391
6Pendular nystagmus (HP:0012043)6.72502156
7Scotoma (HP:0000575)6.65923559
8Abnormality of macular pigmentation (HP:0008002)6.02834074
9Abolished electroretinogram (ERG) (HP:0000550)5.57346535
10Decreased central vision (HP:0007663)5.39498669
11Type II diabetes mellitus (HP:0005978)5.24563699
12Dyschromatopsia (HP:0007641)5.05830163
13Photophobia (HP:0000613)5.01705342
14Keratoconus (HP:0000563)4.93152905
15Increased corneal curvature (HP:0100692)4.93152905
16Retinitis pigmentosa (HP:0000510)4.52743590
17Constricted visual fields (HP:0001133)3.96070051
18Cone-rod dystrophy (HP:0000548)3.92312964
19Vitreoretinal degeneration (HP:0000655)3.89176849
20Methylmalonic acidemia (HP:0002912)3.68371692
21Macular degeneration (HP:0000608)3.61733841
22Hypothermia (HP:0002045)3.56294990
23Posterior subcapsular cataract (HP:0007787)3.54241676
24Gait imbalance (HP:0002141)3.45857743
25Congenital primary aphakia (HP:0007707)3.45004566
26Severe visual impairment (HP:0001141)3.41587288
27Progressive macrocephaly (HP:0004481)3.32821819
28Nephrogenic diabetes insipidus (HP:0009806)3.26069990
29Acute necrotizing encephalopathy (HP:0006965)3.21037946
30Choroideremia (HP:0001139)3.17152383
31Hypomagnesemia (HP:0002917)3.07717763
32Pancreatic fibrosis (HP:0100732)3.07202100
33Abnormality of the labia minora (HP:0012880)3.06356914
34Medial flaring of the eyebrow (HP:0010747)2.94889878
35Progressive visual loss (HP:0000529)2.87636593
36Retinal atrophy (HP:0001105)2.86907888
37Acute encephalopathy (HP:0006846)2.86368192
38Abnormality of vitamin B metabolism (HP:0004340)2.80927879
39Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77340841
40Progressive inability to walk (HP:0002505)2.77015297
41Pancreatic cysts (HP:0001737)2.72443740
42Abnormal mitochondria in muscle tissue (HP:0008316)2.72189882
43Intestinal atresia (HP:0011100)2.70403948
44Methylmalonic aciduria (HP:0012120)2.68509903
45Aplasia/hypoplasia of the uterus (HP:0008684)2.67465540
46Optic disc pallor (HP:0000543)2.64499973
47Increased CSF lactate (HP:0002490)2.59510983
48Mitochondrial inheritance (HP:0001427)2.58784606
49Epileptic encephalopathy (HP:0200134)2.57254775
50True hermaphroditism (HP:0010459)2.47936372
51Poor coordination (HP:0002370)2.47026881
52Hyperglycinemia (HP:0002154)2.44695009
53Vaginal atresia (HP:0000148)2.41052247
54Abnormality of the renal cortex (HP:0011035)2.38716975
55Muscular hypotonia of the trunk (HP:0008936)2.36656697
56Abnormality of the vitamin B12 metabolism (HP:0004341)2.36099726
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.34612765
58Hypoplasia of the fovea (HP:0007750)2.34612765
59Increased circulating renin level (HP:0000848)2.33872083
60Febrile seizures (HP:0002373)2.33619255
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31787376
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31787376
63Large for gestational age (HP:0001520)2.31408406
64Renal cortical cysts (HP:0000803)2.31260026
65Metaphyseal dysplasia (HP:0100255)2.30657821
663-Methylglutaconic aciduria (HP:0003535)2.29838103
67Genital tract atresia (HP:0001827)2.28566931
68Focal motor seizures (HP:0011153)2.27749107
69Hypochromic microcytic anemia (HP:0004840)2.27537698
70Neuroendocrine neoplasm (HP:0100634)2.27228281
71Pancreatic islet-cell hyperplasia (HP:0004510)2.25851207
72Hyperinsulinemic hypoglycemia (HP:0000825)2.24102904
73Cerebral edema (HP:0002181)2.24009574
74Gaze-evoked nystagmus (HP:0000640)2.22940894
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22655167
76Abnormal protein N-linked glycosylation (HP:0012347)2.22655167
77Abnormal protein glycosylation (HP:0012346)2.22655167
78Abnormal glycosylation (HP:0012345)2.22655167
79Wide nasal bridge (HP:0000431)2.19084711
80Hypoglycemic coma (HP:0001325)2.18578088
81Abnormality of the fovea (HP:0000493)2.16049377
82Nephronophthisis (HP:0000090)2.14359765
83Bile duct proliferation (HP:0001408)2.13833942
84Abnormal biliary tract physiology (HP:0012439)2.13833942
85Papillary thyroid carcinoma (HP:0002895)2.12448307
86Renal Fanconi syndrome (HP:0001994)2.12154030
87Short tibia (HP:0005736)2.10073385
88Abnormality of renal resorption (HP:0011038)2.08856456
89Thyroid carcinoma (HP:0002890)2.07688256
90Hypsarrhythmia (HP:0002521)2.07328373
91Hypoplasia of the uterus (HP:0000013)2.07034001
92Pheochromocytoma (HP:0002666)2.05956561
93Abnormality of magnesium homeostasis (HP:0004921)2.03941480
94EEG with generalized epileptiform discharges (HP:0011198)2.03139259
95Ketoacidosis (HP:0001993)2.01926394
96Abnormality of endocrine pancreas physiology (HP:0012093)2.01694524
97Abnormality of the pancreatic islet cells (HP:0006476)2.01694524
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.01454083
99Abnormality of methionine metabolism (HP:0010901)2.00019446
100Congenital stationary night blindness (HP:0007642)12.0940014
101Bony spicule pigmentary retinopathy (HP:0007737)11.4519926
102Abnormal rod and cone electroretinograms (HP:0008323)10.6464382
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.99772801
104Type I transferrin isoform profile (HP:0003642)1.99689654
105Inability to walk (HP:0002540)1.99506086
106Stomatitis (HP:0010280)1.99432049
107Neoplasm of the adrenal cortex (HP:0100641)1.98566156
108Disproportionate short-trunk short stature (HP:0003521)1.97887462
109Increased hepatocellular lipid droplets (HP:0006565)1.97785330
110Epileptiform EEG discharges (HP:0011182)1.95151651
111Molar tooth sign on MRI (HP:0002419)1.94381398
112Abnormality of midbrain morphology (HP:0002418)1.94381398
113Atonic seizures (HP:0010819)1.93909196
114Subcapsular cataract (HP:0000523)1.92953437
115Hepatic necrosis (HP:0002605)1.92257213
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91878859
117Abnormality of the renal medulla (HP:0100957)1.91049255
118Hypoglycemic seizures (HP:0002173)1.91013229
119Aplasia/Hypoplasia of the lens (HP:0008063)1.88744956
120Abnormal drinking behavior (HP:0030082)1.86902874
121Polydipsia (HP:0001959)1.86902874
122Neoplasm of the adrenal gland (HP:0100631)1.86128274
123Fair hair (HP:0002286)1.85049975
124Generalized myoclonic seizures (HP:0002123)1.83633350
125Lipid accumulation in hepatocytes (HP:0006561)1.83333196
126Ketosis (HP:0001946)1.82676934
127Hyperventilation (HP:0002883)1.82477298
128Lactic acidosis (HP:0003128)1.82475719
129Abnormality of vitamin metabolism (HP:0100508)1.82345066
130Lethargy (HP:0001254)1.80893216
131Delayed gross motor development (HP:0002194)1.78413393
132Abnormality of the metopic suture (HP:0005556)1.76577452
133Glycosuria (HP:0003076)1.74639795
134Abnormality of urine glucose concentration (HP:0011016)1.74639795
135Optic atrophy (HP:0000648)1.73253278
136Abnormality of alanine metabolism (HP:0010916)1.72910057
137Hyperalaninemia (HP:0003348)1.72910057
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72910057
139Thyroiditis (HP:0100646)1.72597436
140Dysdiadochokinesis (HP:0002075)1.66353779
141Broad foot (HP:0001769)1.65896829
142Astigmatism (HP:0000483)1.64732569
143Absence seizures (HP:0002121)1.56037738
144Cystic liver disease (HP:0006706)1.54798193
145Dialeptic seizures (HP:0011146)1.50982961
146Left ventricular hypertrophy (HP:0001712)1.44609469
147Aplasia/Hypoplasia of the macula (HP:0008059)1.41499054
148Decreased testicular size (HP:0008734)1.40967602
149Congenital sensorineural hearing impairment (HP:0008527)1.37784628
150Horizontal nystagmus (HP:0000666)1.36128109
151Abnormality of dental color (HP:0011073)1.31751431
152Aplasia involving bones of the upper limbs (HP:0009823)1.30713351
153Aplasia of the phalanges of the hand (HP:0009802)1.30713351
154Aplasia involving bones of the extremities (HP:0009825)1.30713351
155Median cleft lip (HP:0000161)1.30389422
156Specific learning disability (HP:0001328)1.25696540
157Cerebral hypomyelination (HP:0006808)1.23869775
158Sclerocornea (HP:0000647)1.21446470
159Follicular hyperkeratosis (HP:0007502)1.21264912
160Aplasia/Hypoplasia affecting the retina (HP:0008061)1.20792105
161Furrowed tongue (HP:0000221)1.20648511
162Alopecia of scalp (HP:0002293)1.20318632
163Asthma (HP:0002099)1.20301695
164Occipital encephalocele (HP:0002085)1.19845515
165Abnormality of liposaccharide metabolism (HP:0010968)1.15913917
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.15913917
167Abnormality of glycolipid metabolism (HP:0010969)1.15913917
168Hypoplastic left heart (HP:0004383)1.15641162
169Focal seizures (HP:0007359)1.13398155
170Severe Myopia (HP:0011003)1.11676701
171Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.11573589
172Hemiparesis (HP:0001269)1.11368613
173Chronic hepatic failure (HP:0100626)1.09908552
174Interstitial pulmonary disease (HP:0006530)1.09307196
175Adrenal hypoplasia (HP:0000835)1.09223854
176Retinal detachment (HP:0000541)1.08546058
177Chorioretinal coloboma (HP:0000567)1.06284400
178Postaxial hand polydactyly (HP:0001162)1.05938559
179Diplopia (HP:0000651)1.05198056
180Abnormality of binocular vision (HP:0011514)1.05198056
181Visual hallucinations (HP:0002367)1.03772971
182Congenital hepatic fibrosis (HP:0002612)1.03016500
183Hypodontia (HP:0000668)1.02604863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK27.89374524
2TNIK5.16891941
3PBK4.91361250
4GRK14.89482668
5FRK4.21483914
6MKNK14.08304187
7MAP4K23.39445187
8PINK13.33345904
9AKT33.04853861
10BMPR1B2.47175596
11ACVR1B2.34295242
12WNK32.30069335
13OXSR12.24062221
14BUB12.03953218
15TAOK31.91885136
16STK391.86138598
17TRIM281.81949744
18NEK11.77622384
19ERBB31.75999798
20BCKDK1.69729440
21EIF2AK11.66845224
22PRKCG1.63680959
23CASK1.61960424
24CSNK1G11.59905635
25ZAK1.58055472
26STK161.54989398
27MAP3K41.51374309
28MAP2K71.46591136
29PLK21.33691484
30FGFR21.30166820
31WEE11.28859875
32CSNK1G31.25420437
33ADRBK21.20748270
34MAPK121.15476618
35CSNK1G21.15401467
36NME11.14739780
37CDK81.08945006
38SRPK11.07443767
39LMTK21.07241286
40FER1.06234448
41BCR1.05771169
42INSRR1.02331301
43EPHA21.02046097
44BRSK21.00580912
45PHKG10.98814963
46PHKG20.98814963
47NTRK30.97881626
48PNCK0.96821512
49CDK190.95655232
50STK240.93945970
51TSSK60.93393450
52PLK30.92100898
53CCNB10.90089336
54STK38L0.89344870
55VRK10.88908372
56PRKD30.87479868
57EPHA40.87046286
58TAF10.86684880
59CSNK1A1L0.83086779
60PAK60.82707158
61CDK30.81630872
62ARAF0.80759117
63GRK50.78029327
64PRKCE0.77777067
65FLT30.75950531
66TNK20.75516086
67BRSK10.72301745
68MAPK70.71903176
69TESK20.68906332
70NEK20.68868811
71MAP3K90.67723383
72CHEK20.67427473
73MINK10.66802869
74EIF2AK30.65178043
75MUSK0.64717236
76PRKCI0.64532146
77MAP3K140.63871595
78CAMK2D0.61772344
79SGK2230.61213828
80SGK4940.61213828
81STK30.60301235
82FES0.59184553
83MAP3K120.56892917
84NUAK10.56109145
85CAMKK20.54491508
86BRD40.53336247
87MAPK130.53030710
88ADRBK10.53014740
89PASK0.52924372
90PDK20.52850535
91CLK10.52764293
92DYRK1A0.52249794
93MARK10.52055787
94PLK40.51293654
95OBSCN0.50762504
96YES10.50089539
97SGK30.49568344
98VRK20.49179153
99TGFBR10.49116343
100MAP3K20.48829980
101MAP2K40.48576368
102DAPK20.47195978
103STK380.46812724
104PTK2B0.46670229
105PAK30.46410641
106IRAK20.46366487
107MARK30.45415321
108LIMK10.45165762
109KSR10.44592807
110BRAF0.44255076
111PRKAA10.43132771
112PIK3CA0.42985175
113SGK20.42380568
114PRKACB0.42275218
115EIF2AK20.42188452
116DYRK30.41376794
117NTRK20.41213547
118GRK70.40019587
119PRKD20.39639843
120PRKCB0.39628741
121MAP2K10.39474349
122CAMK2A0.39403594
123SCYL20.38645132
124EPHA30.38555332
125PRKCA0.38275447
126EGFR0.37335364
127AURKA0.37301053
128PRKACA0.36457047
129NLK0.36275577
130PRKACG0.34695447
131MAP3K30.34121092
132NEK60.33498339
133CSNK1A10.32077291
134TAOK20.32035461
135STK110.31853848
136CDK90.30974377
137LATS20.30679485
138CAMK2G0.30649901
139MAP3K50.30470170
140CDK50.30256841
141RAF10.30132716
142MAPK100.30053424
143PRKCH0.30001685
144ABL10.29983851
145PRKG10.29890079
146PLK10.29302408
147KDR0.29235553
148PDK30.27593213
149PDK40.27593213
150PRPF4B0.27128751
151MST40.26804772
152GSK3B0.24490262
153RPS6KA40.24039691

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006402.85429368
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70330583
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65479071
4Synaptic vesicle cycle_Homo sapiens_hsa047212.47915252
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42165384
6Butanoate metabolism_Homo sapiens_hsa006502.19646229
7Olfactory transduction_Homo sapiens_hsa047402.10388216
8GABAergic synapse_Homo sapiens_hsa047272.08096754
9Sulfur metabolism_Homo sapiens_hsa009202.06624144
10Basal transcription factors_Homo sapiens_hsa030222.03312141
11Phototransduction_Homo sapiens_hsa0474413.7761271
12Nicotine addiction_Homo sapiens_hsa050331.65728076
13Regulation of autophagy_Homo sapiens_hsa041401.65119693
14Peroxisome_Homo sapiens_hsa041461.62789010
15Tryptophan metabolism_Homo sapiens_hsa003801.53154136
16Vitamin B6 metabolism_Homo sapiens_hsa007501.50747999
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48214578
18Circadian rhythm_Homo sapiens_hsa047101.45774652
19Morphine addiction_Homo sapiens_hsa050321.41027802
20Homologous recombination_Homo sapiens_hsa034401.36230171
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34239880
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33850735
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.33360755
24RNA degradation_Homo sapiens_hsa030181.29390836
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.25356321
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24442539
27Collecting duct acid secretion_Homo sapiens_hsa049661.22397361
28Circadian entrainment_Homo sapiens_hsa047131.14333845
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13252334
30Glutathione metabolism_Homo sapiens_hsa004801.12682566
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11677154
32Non-homologous end-joining_Homo sapiens_hsa034501.08108662
33Mismatch repair_Homo sapiens_hsa034301.06139265
34Glutamatergic synapse_Homo sapiens_hsa047240.99095758
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98325665
36Chemical carcinogenesis_Homo sapiens_hsa052040.97995426
37Vibrio cholerae infection_Homo sapiens_hsa051100.96103570
38Legionellosis_Homo sapiens_hsa051340.95404891
39Cholinergic synapse_Homo sapiens_hsa047250.94847263
40Fanconi anemia pathway_Homo sapiens_hsa034600.94407441
41mTOR signaling pathway_Homo sapiens_hsa041500.93333730
42Purine metabolism_Homo sapiens_hsa002300.93317682
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88107817
44Caffeine metabolism_Homo sapiens_hsa002320.86352162
45Fatty acid degradation_Homo sapiens_hsa000710.85402568
46Fructose and mannose metabolism_Homo sapiens_hsa000510.84721994
47Selenocompound metabolism_Homo sapiens_hsa004500.83730056
48Dopaminergic synapse_Homo sapiens_hsa047280.82893105
49beta-Alanine metabolism_Homo sapiens_hsa004100.82794917
50Serotonergic synapse_Homo sapiens_hsa047260.81998334
51Fatty acid metabolism_Homo sapiens_hsa012120.79836445
52Insulin secretion_Homo sapiens_hsa049110.79474530
53RNA polymerase_Homo sapiens_hsa030200.79267919
54Nitrogen metabolism_Homo sapiens_hsa009100.77698496
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77087808
56Steroid biosynthesis_Homo sapiens_hsa001000.74546902
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73917076
58N-Glycan biosynthesis_Homo sapiens_hsa005100.72473343
59Nucleotide excision repair_Homo sapiens_hsa034200.71833050
60Oxidative phosphorylation_Homo sapiens_hsa001900.69882028
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69755507
62Taste transduction_Homo sapiens_hsa047420.66856562
63Proteasome_Homo sapiens_hsa030500.66801477
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61079011
65Inositol phosphate metabolism_Homo sapiens_hsa005620.60997510
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60014110
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.59379628
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59376141
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59212887
70Lysosome_Homo sapiens_hsa041420.57415870
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57295245
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57144481
73Pentose phosphate pathway_Homo sapiens_hsa000300.57054840
74One carbon pool by folate_Homo sapiens_hsa006700.55616050
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55537536
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55256990
77Mineral absorption_Homo sapiens_hsa049780.53680461
78Salivary secretion_Homo sapiens_hsa049700.53473371
79Cardiac muscle contraction_Homo sapiens_hsa042600.53235690
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52426032
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50144683
82Type I diabetes mellitus_Homo sapiens_hsa049400.49834342
83Pyruvate metabolism_Homo sapiens_hsa006200.48953171
84Rheumatoid arthritis_Homo sapiens_hsa053230.48845781
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48695224
86Dilated cardiomyopathy_Homo sapiens_hsa054140.48319244
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45312561
88Arachidonic acid metabolism_Homo sapiens_hsa005900.45089141
89Vitamin digestion and absorption_Homo sapiens_hsa049770.45066959
90Pyrimidine metabolism_Homo sapiens_hsa002400.43157157
91Fat digestion and absorption_Homo sapiens_hsa049750.42827118
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42685776
93Biosynthesis of amino acids_Homo sapiens_hsa012300.42459963
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42151549
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41675284
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41364739
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40763905
98Dorso-ventral axis formation_Homo sapiens_hsa043200.40210356
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38477231
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37445431
101Sphingolipid metabolism_Homo sapiens_hsa006000.36546998
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36304865
103Glycerolipid metabolism_Homo sapiens_hsa005610.36022430
104Parkinsons disease_Homo sapiens_hsa050120.35011533
105HIF-1 signaling pathway_Homo sapiens_hsa040660.34845055
106Oxytocin signaling pathway_Homo sapiens_hsa049210.34440974
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34368049
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33351704
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.33344255
110Long-term potentiation_Homo sapiens_hsa047200.33160648
111Oocyte meiosis_Homo sapiens_hsa041140.32674191
112Fatty acid elongation_Homo sapiens_hsa000620.32569299
113Folate biosynthesis_Homo sapiens_hsa007900.32517578
114Ras signaling pathway_Homo sapiens_hsa040140.31407947
115cAMP signaling pathway_Homo sapiens_hsa040240.31053329
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30852532
117Melanoma_Homo sapiens_hsa052180.30232182
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30214489
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30005942
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29293414
121Pancreatic secretion_Homo sapiens_hsa049720.29101417
122Calcium signaling pathway_Homo sapiens_hsa040200.28753603
123Gastric acid secretion_Homo sapiens_hsa049710.27797898
124Phagosome_Homo sapiens_hsa041450.27597275
125Huntingtons disease_Homo sapiens_hsa050160.25808480
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25407409
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24831644
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.24733761
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23979600
130Ether lipid metabolism_Homo sapiens_hsa005650.23272814
131RNA transport_Homo sapiens_hsa030130.23001033
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22714248
133Thyroid hormone synthesis_Homo sapiens_hsa049180.22702228
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21944998
135Linoleic acid metabolism_Homo sapiens_hsa005910.21679221
136Galactose metabolism_Homo sapiens_hsa000520.21227794
137Protein export_Homo sapiens_hsa030600.20740497
138Retinol metabolism_Homo sapiens_hsa008300.20445871
139Renin secretion_Homo sapiens_hsa049240.20385686
140ABC transporters_Homo sapiens_hsa020100.19132223
141Alzheimers disease_Homo sapiens_hsa050100.18541169
142Amphetamine addiction_Homo sapiens_hsa050310.17957655
143GnRH signaling pathway_Homo sapiens_hsa049120.17803512
144Metabolic pathways_Homo sapiens_hsa011000.17439057
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15882279
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15808086
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.15723607
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15330200
149Autoimmune thyroid disease_Homo sapiens_hsa053200.14891499

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