CCDC129

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung lobe morphogenesis (GO:0060463)8.86639407
2negative regulation of epidermal cell differentiation (GO:0045605)5.64861207
3protein K11-linked deubiquitination (GO:0035871)5.63894950
4face development (GO:0060324)5.57533954
5regulation of keratinocyte proliferation (GO:0010837)5.45696897
6interferon-gamma secretion (GO:0072643)5.45015376
7tryptophan catabolic process (GO:0006569)5.22223243
8indole-containing compound catabolic process (GO:0042436)5.22223243
9indolalkylamine catabolic process (GO:0046218)5.22223243
10detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.78911533
11piRNA metabolic process (GO:0034587)4.76626572
12monoubiquitinated protein deubiquitination (GO:0035520)4.70928270
13signal peptide processing (GO:0006465)4.65457891
14L-ascorbic acid metabolic process (GO:0019852)4.60826432
15cilium or flagellum-dependent cell motility (GO:0001539)4.56542731
16kynurenine metabolic process (GO:0070189)4.55079995
17negative regulation of complement activation (GO:0045916)4.52438972
18detection of light stimulus involved in visual perception (GO:0050908)4.51370105
19detection of light stimulus involved in sensory perception (GO:0050962)4.51370105
20regulation of meiosis I (GO:0060631)4.48110614
21DNA methylation involved in gamete generation (GO:0043046)4.44485913
22negative regulation of epidermis development (GO:0045683)4.31269818
23meiotic chromosome segregation (GO:0045132)4.30900503
24indolalkylamine metabolic process (GO:0006586)4.28393718
25photoreceptor cell maintenance (GO:0045494)4.27323670
26valine metabolic process (GO:0006573)4.15528487
27pyrimidine-containing compound transmembrane transport (GO:0072531)4.08501831
28tryptophan metabolic process (GO:0006568)4.01006337
29establishment of protein localization to Golgi (GO:0072600)3.98655178
30tachykinin receptor signaling pathway (GO:0007217)3.97665133
31ethanol oxidation (GO:0006069)3.94561120
32protein K48-linked deubiquitination (GO:0071108)3.93470353
33regulation of hippo signaling (GO:0035330)3.93153792
34keratinocyte development (GO:0003334)3.91000593
35interleukin-6-mediated signaling pathway (GO:0070102)3.89620924
36hepatocyte apoptotic process (GO:0097284)3.89580426
37acrosome assembly (GO:0001675)3.79615925
38neural tube formation (GO:0001841)3.75934709
39protein localization to endosome (GO:0036010)3.74957920
40UDP-N-acetylglucosamine metabolic process (GO:0006047)3.71248728
41negative regulation of protein activation cascade (GO:2000258)3.70601431
42cellular ketone body metabolic process (GO:0046950)3.70238220
43hemidesmosome assembly (GO:0031581)3.69001053
44surfactant homeostasis (GO:0043129)3.67722468
45lung vasculature development (GO:0060426)3.67187129
46intestinal epithelial cell development (GO:0060576)3.62845556
47vitamin transmembrane transport (GO:0035461)3.59805884
48retinal cone cell development (GO:0046549)3.57663782
49ketone body metabolic process (GO:1902224)3.54748503
50bundle of His cell to Purkinje myocyte communication (GO:0086069)3.54625660
51growth hormone receptor signaling pathway (GO:0060396)3.53920702
52multicellular organism reproduction (GO:0032504)3.52210830
53male meiosis (GO:0007140)3.51243096
54negative regulation of keratinocyte proliferation (GO:0010839)3.50780350
55auditory receptor cell stereocilium organization (GO:0060088)3.47146890
56regulation of keratinocyte differentiation (GO:0045616)3.45073072
57interkinetic nuclear migration (GO:0022027)3.41490137
58dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.41244799
59reciprocal DNA recombination (GO:0035825)3.40900542
60reciprocal meiotic recombination (GO:0007131)3.40900542
61negative regulation of mast cell activation (GO:0033004)3.38064399
62regulation of MHC class II biosynthetic process (GO:0045346)3.32198631
63regulation of memory T cell differentiation (GO:0043380)3.30476040
64chemical homeostasis within a tissue (GO:0048875)3.29788484
65response to pheromone (GO:0019236)3.29279446
66sperm motility (GO:0030317)3.28770832
67reflex (GO:0060004)3.28653926
68oxidative demethylation (GO:0070989)3.25537681
69hormone catabolic process (GO:0042447)3.24836266
70cellular biogenic amine catabolic process (GO:0042402)3.22188763
71amine catabolic process (GO:0009310)3.22188763
72renal absorption (GO:0070293)3.20548544
73negative regulation of humoral immune response (GO:0002921)3.20498590
74negative regulation of granulocyte differentiation (GO:0030853)3.17797300
75protein targeting to Golgi (GO:0000042)3.17004836
76detection of mechanical stimulus involved in sensory perception (GO:0050974)3.16678655
77NAD biosynthetic process (GO:0009435)3.16264943
78protein polyglutamylation (GO:0018095)3.16214521
79centriole replication (GO:0007099)3.16187227
80limb bud formation (GO:0060174)3.14752316
81folic acid transport (GO:0015884)3.14628791
82drinking behavior (GO:0042756)3.14072484
83regulation of posttranscriptional gene silencing (GO:0060147)3.12761465
84regulation of gene silencing by miRNA (GO:0060964)3.12761465
85regulation of gene silencing by RNA (GO:0060966)3.12761465
86peptide catabolic process (GO:0043171)3.11884126
87positive regulation of vasculogenesis (GO:2001214)3.10403158
88indole-containing compound metabolic process (GO:0042430)3.07787726
89retrograde transport, vesicle recycling within Golgi (GO:0000301)3.06739225
90axoneme assembly (GO:0035082)3.05758887
91regulation of female gonad development (GO:2000194)3.05020869
92regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.03726519
93positive regulation of osteoblast proliferation (GO:0033690)3.02219427
94facial nerve structural organization (GO:0021612)3.01421881
95positive regulation of wound healing (GO:0090303)2.98714530
96cellular response to growth hormone stimulus (GO:0071378)2.98710814
97protein K63-linked deubiquitination (GO:0070536)2.98693391
98DNA deamination (GO:0045006)2.98044429
99pattern specification involved in kidney development (GO:0061004)2.97635844
100aromatic amino acid family catabolic process (GO:0009074)2.95723235
101cell wall macromolecule metabolic process (GO:0044036)2.94780884
102phosphatidylinositol acyl-chain remodeling (GO:0036149)2.94228953
103negative regulation of fatty acid transport (GO:2000192)2.93885005
104urinary tract smooth muscle contraction (GO:0014848)2.92936069
105male meiosis I (GO:0007141)2.92248022
106multicellular organismal water homeostasis (GO:0050891)2.90376967
107cilium movement (GO:0003341)2.89090284
108gamma-aminobutyric acid transport (GO:0015812)2.88986340
109regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.88575017
110inner ear receptor stereocilium organization (GO:0060122)2.85107290
111cellular response to ethanol (GO:0071361)2.84225108
112behavioral response to pain (GO:0048266)2.84136516
113positive regulation of p38MAPK cascade (GO:1900745)2.82961141
114lymphangiogenesis (GO:0001946)2.82292568
115flavonoid metabolic process (GO:0009812)2.81572234
116sphingoid metabolic process (GO:0046519)2.81418702
117central nervous system neuron axonogenesis (GO:0021955)2.80139738
118desmosome organization (GO:0002934)2.79698437
119peptidyl-threonine dephosphorylation (GO:0035970)2.78828838
120arginine catabolic process (GO:0006527)2.78753139
121negative regulation of sodium ion transport (GO:0010766)2.78533027
122L-serine transport (GO:0015825)2.78165371
123synapsis (GO:0007129)2.78134012
124cardiac ventricle morphogenesis (GO:0003208)2.77814155
125bone remodeling (GO:0046849)2.77488935
126lung-associated mesenchyme development (GO:0060484)2.76435764
127benzene-containing compound metabolic process (GO:0042537)2.76354703
128thyroid hormone metabolic process (GO:0042403)2.76055854
129positive regulation of steroid hormone secretion (GO:2000833)2.75868976
130gene silencing by RNA (GO:0031047)2.75754019
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73613417
132negative regulation of translation, ncRNA-mediated (GO:0040033)2.72788033
133regulation of translation, ncRNA-mediated (GO:0045974)2.72788033
134negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72788033
135DNA demethylation (GO:0080111)2.72725978
136negative regulation of systemic arterial blood pressure (GO:0003085)2.72580844
137embryonic cranial skeleton morphogenesis (GO:0048701)2.72313681
138lung alveolus development (GO:0048286)2.71964550
139behavioral response to nicotine (GO:0035095)2.71622243
140axonemal dynein complex assembly (GO:0070286)2.71468115
141hematopoietic stem cell proliferation (GO:0071425)2.71212422
142epithelial cilium movement (GO:0003351)2.71148273
143female gamete generation (GO:0007292)2.71030460
144negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70874587
145regulation of epidermal cell differentiation (GO:0045604)2.70267139
146O-glycan processing (GO:0016266)2.68971402
147histone H3-K4 trimethylation (GO:0080182)2.68817655
148ethanol metabolic process (GO:0006067)2.68177193
149negative regulation of calcium ion transport into cytosol (GO:0010523)2.67375583
150sperm-egg recognition (GO:0035036)2.66703186
151metanephric mesenchyme development (GO:0072075)2.66649519
152positive regulation of canonical Wnt signaling pathway (GO:0090263)2.65317760
153killing of cells of other organism (GO:0031640)2.65187617
154disruption of cells of other organism (GO:0044364)2.65187617
155drug catabolic process (GO:0042737)2.64911484
156radial glial cell differentiation (GO:0060019)2.64649928
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64547429
158branching involved in labyrinthine layer morphogenesis (GO:0060670)2.64418482
159cilium organization (GO:0044782)2.63964338
160positive regulation of digestive system process (GO:0060456)2.63123174
161cilium assembly (GO:0042384)2.62514079
162transepithelial transport (GO:0070633)2.61849271
163cell wall macromolecule catabolic process (GO:0016998)2.60388872
164lung epithelium development (GO:0060428)2.59755162
165cellular copper ion homeostasis (GO:0006878)2.59355874
166calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.58536824
167lung secretory cell differentiation (GO:0061140)2.57474329
168positive regulation of developmental pigmentation (GO:0048087)2.57383541
169omega-hydroxylase P450 pathway (GO:0097267)2.56713914
170fucose catabolic process (GO:0019317)2.56699742
171L-fucose metabolic process (GO:0042354)2.56699742
172L-fucose catabolic process (GO:0042355)2.56699742
173acrosome reaction (GO:0007340)2.56617112
174acute-phase response (GO:0006953)2.56204483
175toxin transport (GO:1901998)2.56177754
176ear development (GO:0043583)2.55911833
177positive regulation of glucose import (GO:0046326)2.55288538
178regulation of podosome assembly (GO:0071801)2.51325068
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49847662
180cytokine production involved in immune response (GO:0002367)2.49368741
181modified amino acid transport (GO:0072337)2.47669405
182water homeostasis (GO:0030104)2.47283842
183lateral sprouting from an epithelium (GO:0060601)2.47157373
184nuclear envelope reassembly (GO:0031468)2.45336818
185mitotic nuclear envelope reassembly (GO:0007084)2.45336818
186xenobiotic catabolic process (GO:0042178)2.44900532
187regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.44751119
188regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.42216404
189import into cell (GO:0098657)2.41573329
190negative regulation of epithelial cell differentiation (GO:0030857)2.41081873
191positive regulation of blood coagulation (GO:0030194)2.40584855
192positive regulation of hemostasis (GO:1900048)2.40584855
193dendritic spine morphogenesis (GO:0060997)2.40234267
194regulation of axon extension involved in axon guidance (GO:0048841)2.38947511
195cardiac chamber morphogenesis (GO:0003206)2.37072475
196positive regulation of glucose transport (GO:0010828)2.36565219
197copper ion transport (GO:0006825)2.35776342
198glial cell proliferation (GO:0014009)2.35133080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.39137448
2GBX2_23144817_ChIP-Seq_PC3_Human3.45068617
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.27054647
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.24354898
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10002536
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.93126011
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.91071166
8VDR_22108803_ChIP-Seq_LS180_Human2.84205981
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.78327671
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.58766072
11EZH2_22144423_ChIP-Seq_EOC_Human2.43657124
12IGF1R_20145208_ChIP-Seq_DFB_Human2.43581300
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.42353294
14ZNF274_21170338_ChIP-Seq_K562_Hela2.41661579
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39109031
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38070098
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30421135
18AHR_22903824_ChIP-Seq_MCF-7_Human2.22167017
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17374676
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.16307765
21TAF15_26573619_Chip-Seq_HEK293_Human2.13583547
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.10462864
23ER_23166858_ChIP-Seq_MCF-7_Human2.08823039
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03364778
25* P300_19829295_ChIP-Seq_ESCs_Human2.03211686
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00377398
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97434353
28STAT3_23295773_ChIP-Seq_U87_Human1.96302267
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94949474
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88337046
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.85843974
32AR_21572438_ChIP-Seq_LNCaP_Human1.85381324
33CBP_20019798_ChIP-Seq_JUKART_Human1.82894564
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.82894564
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81560743
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.80758393
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79462433
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78986685
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78740841
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78339881
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76557346
42EWS_26573619_Chip-Seq_HEK293_Human1.75939485
43FUS_26573619_Chip-Seq_HEK293_Human1.72723131
44* TCF4_23295773_ChIP-Seq_U87_Human1.70870983
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69755849
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69561905
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69561905
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69461751
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68026522
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64968497
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.63878674
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63554889
53RXR_22108803_ChIP-Seq_LS180_Human1.62440993
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.61272101
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59204020
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57273744
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56186573
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.54862897
59SOX2_20726797_ChIP-Seq_SW620_Human1.51581438
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49456653
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.48940811
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48894719
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47917295
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.47616821
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47320248
66TCF4_22108803_ChIP-Seq_LS180_Human1.46578096
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45816885
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44793310
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43603897
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41689719
71SOX2_19829295_ChIP-Seq_ESCs_Human1.41319787
72NANOG_19829295_ChIP-Seq_ESCs_Human1.41319787
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.40844322
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40813550
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40813550
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.38497792
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38190068
78* TP53_18474530_ChIP-ChIP_U2OS_Human1.36774814
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.36392904
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36368801
81RUNX2_22187159_ChIP-Seq_PCA_Human1.35348909
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35345707
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34726470
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33240790
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33026688
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.32636663
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.32447189
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32263194
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31725456
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.31446182
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30833114
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30551625
93CDX2_22108803_ChIP-Seq_LS180_Human1.29150199
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29140191
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26256780
96* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26177912
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25717993
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.25511545
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25121574
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24252688
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24164997
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23074918
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.22040845
104TP53_22573176_ChIP-Seq_HFKS_Human1.21460361
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21319226
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20851943
107* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20223243
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.20101177
109DROSHA_22980978_ChIP-Seq_HELA_Human1.20095025
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20068421
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19790624
112KLF5_25053715_ChIP-Seq_YYC3_Human1.18591648
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.18440875
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18363939
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.17939283
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.17450860
117* FOXA1_25329375_ChIP-Seq_VCAP_Human1.17386097
118* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17386097
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17082298
120JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16360703
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15486148
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15082208
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14380022
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.13248059
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12645613
126CLOCK_20551151_ChIP-Seq_293T_Human1.12346498
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12112948
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.11995591
129TP53_16413492_ChIP-PET_HCT116_Human1.11968104
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10709009
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09372010
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09366197
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07702555
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07557966
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07557966
136* AR_20517297_ChIP-Seq_VCAP_Human1.06573515
137ERG_21242973_ChIP-ChIP_JURKAT_Human1.06442311
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06395578
139RNF2_27304074_Chip-Seq_ESCs_Mouse1.05043155
140TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04157662
141OCT1_27270436_Chip-Seq_PROSTATE_Human1.04142464
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.03765726
143KDM2B_26808549_Chip-Seq_REH_Human1.03490725
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03429521
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03361911
146TP53_20018659_ChIP-ChIP_R1E_Mouse1.03248452
147AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02455441
148ZNF263_19887448_ChIP-Seq_K562_Human1.01324313
149GATA4_25053715_ChIP-Seq_YYC3_Human1.01165051
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01081831
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.99788341
152CJUN_26792858_Chip-Seq_BT549_Human0.99329817
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98577869
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97767307
155* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97650698
156NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96692898
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96670767
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96549070
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96439454
160* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95517076
161RING1B_27294783_Chip-Seq_NPCs_Mouse0.95508569
162SMAD_19615063_ChIP-ChIP_OVARY_Human0.94402824
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.94266450
164VDR_24787735_ChIP-Seq_THP-1_Human0.93368871
165NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93283967
166GATA3_24758297_ChIP-Seq_MCF-7_Human0.93222879
167RACK7_27058665_Chip-Seq_MCF-7_Human0.92895372
168LXR_22158963_ChIP-Seq_LIVER_Mouse0.91674345
169BCAT_22108803_ChIP-Seq_LS180_Human0.91340314
170SMAD4_21799915_ChIP-Seq_A2780_Human0.90203744
171AR_25329375_ChIP-Seq_VCAP_Human0.89397207
172SCL_19346495_ChIP-Seq_HPC-7_Human0.88556093
173RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88446796
174EZH2_27304074_Chip-Seq_ESCs_Mouse0.84485007
175TP63_23658742_ChIP-Seq_EP156T_Human0.84383764
176GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84137806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.41097247
2MP0002254_reproductive_system_inflammat5.38298509
3MP0002877_abnormal_melanocyte_morpholog5.00011546
4MP0001346_abnormal_lacrimal_gland4.79844305
5MP0008877_abnormal_DNA_methylation3.90419972
6MP0010030_abnormal_orbit_morphology3.46952790
7MP0008789_abnormal_olfactory_epithelium3.40804095
8MP0003195_calcinosis3.34976422
9MP0000566_synostosis3.12886191
10MP0008875_abnormal_xenobiotic_pharmacok3.10604105
11MP0003136_yellow_coat_color2.87336218
12MP0002132_abnormal_respiratory_system2.82738358
13MP0005499_abnormal_olfactory_system2.81391823
14MP0005394_taste/olfaction_phenotype2.81391823
15MP0001881_abnormal_mammary_gland2.69260967
16MP0005410_abnormal_fertilization2.62328110
17MP0005551_abnormal_eye_electrophysiolog2.61827891
18MP0001501_abnormal_sleep_pattern2.46653833
19MP0003646_muscle_fatigue2.43256483
20MP0002736_abnormal_nociception_after2.42696092
21MP0000762_abnormal_tongue_morphology2.41607426
22MP0006054_spinal_hemorrhage2.38232865
23MP0003300_gastrointestinal_ulcer2.37826437
24MP0001958_emphysema2.31838043
25MP0001968_abnormal_touch/_nociception2.28723980
26MP0003718_maternal_effect2.27463875
27MP0008057_abnormal_DNA_replication2.27281959
28MP0005670_abnormal_white_adipose2.23985763
29MP0005310_abnormal_salivary_gland2.21771658
30MP0009053_abnormal_anal_canal2.17103203
31MP0005174_abnormal_tail_pigmentation2.16327193
32MP0002837_dystrophic_cardiac_calcinosis2.12659218
33MP0000678_abnormal_parathyroid_gland2.10502908
34MP0010234_abnormal_vibrissa_follicle2.02638326
35MP0002277_abnormal_respiratory_mucosa2.02366203
36MP0000537_abnormal_urethra_morphology2.01236198
37MP0005248_abnormal_Harderian_gland1.99002294
38MP0001485_abnormal_pinna_reflex1.97189365
39MP0002098_abnormal_vibrissa_morphology1.91061566
40MP0002138_abnormal_hepatobiliary_system1.88975821
41MP0001177_atelectasis1.87497794
42MP0004019_abnormal_vitamin_homeostasis1.85044051
43MP0005253_abnormal_eye_physiology1.83905759
44MP0003566_abnormal_cell_adhesion1.83575040
45MP0003950_abnormal_plasma_membrane1.83412083
46MP0000427_abnormal_hair_cycle1.83342706
47MP0009046_muscle_twitch1.75582929
48MP0009780_abnormal_chondrocyte_physiolo1.74289440
49MP0005408_hypopigmentation1.74225030
50MP0009745_abnormal_behavioral_response1.72163822
51MP0002653_abnormal_ependyma_morphology1.69962676
52MP0004883_abnormal_blood_vessel1.64134988
53MP0005167_abnormal_blood-brain_barrier1.63696839
54MP0005395_other_phenotype1.60963910
55MP0002735_abnormal_chemical_nociception1.60559078
56MP0000613_abnormal_salivary_gland1.58411998
57MP0005646_abnormal_pituitary_gland1.58224048
58MP0001984_abnormal_olfaction1.55661462
59MP0001486_abnormal_startle_reflex1.55169289
60MP0010368_abnormal_lymphatic_system1.52056716
61MP0006072_abnormal_retinal_apoptosis1.51939535
62MP0003698_abnormal_male_reproductive1.49884306
63MP0005075_abnormal_melanosome_morpholog1.47370908
64MP0000372_irregular_coat_pigmentation1.45860345
65MP0003890_abnormal_embryonic-extraembry1.45567440
66MP0005171_absent_coat_pigmentation1.44124043
67MP0008872_abnormal_physiological_respon1.44002373
68MP0001986_abnormal_taste_sensitivity1.43051850
69MP0001929_abnormal_gametogenesis1.42313742
70MP0002234_abnormal_pharynx_morphology1.40586881
71MP0002896_abnormal_bone_mineralization1.39215458
72MP0004043_abnormal_pH_regulation1.35886130
73MP0000371_diluted_coat_color1.35631321
74MP0002796_impaired_skin_barrier1.32391893
75MP0002233_abnormal_nose_morphology1.28059993
76MP0000627_abnormal_mammary_gland1.27944545
77MP0010678_abnormal_skin_adnexa1.27272366
78MP0000015_abnormal_ear_pigmentation1.26819261
79MP0002133_abnormal_respiratory_system1.26327008
80MP0005388_respiratory_system_phenotype1.26327008
81MP0003045_fibrosis1.23705987
82MP0003828_pulmonary_edema1.23229512
83MP0005647_abnormal_sex_gland1.22619582
84MP0010352_gastrointestinal_tract_polyps1.21997175
85MP0005367_renal/urinary_system_phenotyp1.20919217
86MP0000516_abnormal_urinary_system1.20919217
87MP0004264_abnormal_extraembryonic_tissu1.20620005
88MP0002210_abnormal_sex_determination1.18256273
89MP0002282_abnormal_trachea_morphology1.18055366
90MP0005164_abnormal_response_to1.18047389
91MP0000681_abnormal_thyroid_gland1.16657021
92MP0004885_abnormal_endolymph1.15396333
93MP0003252_abnormal_bile_duct1.15378016
94MP0002095_abnormal_skin_pigmentation1.15207766
95MP0009764_decreased_sensitivity_to1.10750544
96MP0001299_abnormal_eye_distance/1.09921615
97MP0006276_abnormal_autonomic_nervous1.09736338
98MP0002060_abnormal_skin_morphology1.08944219
99MP0000383_abnormal_hair_follicle1.08652312
100MP0005083_abnormal_biliary_tract1.08415090
101MP0002734_abnormal_mechanical_nocicepti1.07892387
102MP0001764_abnormal_homeostasis1.05331800
103MP0002572_abnormal_emotion/affect_behav1.03124840
104MP0002938_white_spotting1.02167746
105MP0005360_urolithiasis1.01787907
106MP0000230_abnormal_systemic_arterial1.00703306
107MP0000467_abnormal_esophagus_morphology0.99951484
108MP0002272_abnormal_nervous_system0.99843714
109MP0010094_abnormal_chromosome_stability0.99564240
110MP0004147_increased_porphyrin_level0.99132763
111MP0000579_abnormal_nail_morphology0.98668877
112MP0005165_increased_susceptibility_to0.97055150
113MP0005166_decreased_susceptibility_to0.96861682
114MP0000653_abnormal_sex_gland0.96855931
115MP0004859_abnormal_synaptic_plasticity0.96845269
116MP0003453_abnormal_keratinocyte_physiol0.96184561
117MP0000377_abnormal_hair_follicle0.94505619
118MP0003879_abnormal_hair_cell0.94305855
119MP0001324_abnormal_eye_pigmentation0.93669395
120MP0000049_abnormal_middle_ear0.92848114
121MP0000462_abnormal_digestive_system0.92261827
122MP0001145_abnormal_male_reproductive0.92210767
123MP0002102_abnormal_ear_morphology0.92047370
124MP0002067_abnormal_sensory_capabilities0.89580036
125MP0004381_abnormal_hair_follicle0.89470951
126MP0002090_abnormal_vision0.89136838
127MP0009250_abnormal_appendicular_skeleto0.88945077
128MP0002909_abnormal_adrenal_gland0.88227778
129MP0005595_abnormal_vascular_smooth0.87407070
130MP0005195_abnormal_posterior_eye0.87326007
131MP0000858_altered_metastatic_potential0.87265713
132MP0005076_abnormal_cell_differentiation0.87233759
133MP0002928_abnormal_bile_duct0.86269988
134MP0002249_abnormal_larynx_morphology0.85450744
135MP0002733_abnormal_thermal_nociception0.84839452
136MP0001970_abnormal_pain_threshold0.84733442
137MP0005508_abnormal_skeleton_morphology0.84175683
138MP0001963_abnormal_hearing_physiology0.84109288
139MP0002557_abnormal_social/conspecific_i0.83273598
140MP0003638_abnormal_response/metabolism_0.83090013
141MP0003878_abnormal_ear_physiology0.81271224
142MP0005377_hearing/vestibular/ear_phenot0.81271224
143MP0010329_abnormal_lipoprotein_level0.81033761
144MP0003787_abnormal_imprinting0.79436186
145MP0000003_abnormal_adipose_tissue0.79271941
146MP0002168_other_aberrant_phenotype0.78680712
147MP0004084_abnormal_cardiac_muscle0.78289028
148MP0003690_abnormal_glial_cell0.77461480
149MP0002229_neurodegeneration0.76312168
150MP0002064_seizures0.75508079
151MP0008058_abnormal_DNA_repair0.74542471
152MP0002876_abnormal_thyroid_physiology0.74031070
153MP0003724_increased_susceptibility_to0.73334061
154MP0001879_abnormal_lymphatic_vessel0.73264717
155MP0004484_altered_response_of0.72876504
156MP0003943_abnormal_hepatobiliary_system0.72135229
157MP0004233_abnormal_muscle_weight0.71326409
158MP0005375_adipose_tissue_phenotype0.70530182
159MP0004215_abnormal_myocardial_fiber0.70196993
160MP0004130_abnormal_muscle_cell0.70195782
161MP0002161_abnormal_fertility/fecundity0.70109444
162MP0000534_abnormal_ureter_morphology0.69732849
163MP0005266_abnormal_metabolism0.68790849
164MP0003137_abnormal_impulse_conducting0.66830679
165MP0001216_abnormal_epidermal_layer0.66712429
166MP0001119_abnormal_female_reproductive0.66505690
167MP0001666_abnormal_nutrient_absorption0.65313497
168MP0000631_abnormal_neuroendocrine_gland0.64891570
169MP0010155_abnormal_intestine_physiology0.64636892
170MP0004142_abnormal_muscle_tone0.64525100
171MP0001849_ear_inflammation0.64385192
172MP0003633_abnormal_nervous_system0.63607658
173MP0003091_abnormal_cell_migration0.62788979
174MP0004742_abnormal_vestibular_system0.62573167
175MP0000465_gastrointestinal_hemorrhage0.61611068
176MP0005666_abnormal_adipose_tissue0.61198624
177MP0002295_abnormal_pulmonary_circulatio0.60524607
178MP0000470_abnormal_stomach_morphology0.60266570
179MP0009115_abnormal_fat_cell0.59141911
180MP0000163_abnormal_cartilage_morphology0.57492745
181MP0001915_intracranial_hemorrhage0.57431949
182MP0005085_abnormal_gallbladder_physiolo0.56911719
183MP0004270_analgesia0.56771580
184MP0004272_abnormal_basement_membrane0.55683997
185MP0009384_cardiac_valve_regurgitation0.55165513

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)5.51308918
2Aplasia involving bones of the upper limbs (HP:0009823)5.51308918
3Aplasia of the phalanges of the hand (HP:0009802)5.51308918
4Progressive cerebellar ataxia (HP:0002073)4.65052915
5Onycholysis (HP:0001806)4.60082698
6Stomach cancer (HP:0012126)4.46928869
7Genetic anticipation (HP:0003743)4.42036377
8Stenosis of the external auditory canal (HP:0000402)4.35581263
9Attenuation of retinal blood vessels (HP:0007843)4.30117293
10Right ventricular cardiomyopathy (HP:0011663)4.28433169
11Choroideremia (HP:0001139)4.16398364
12Pancreatic cysts (HP:0001737)4.16312091
13Gaze-evoked nystagmus (HP:0000640)4.11755077
14Synostosis involving the elbow (HP:0003938)4.01312514
15Humeroradial synostosis (HP:0003041)4.01312514
16Chronic hepatic failure (HP:0100626)3.84702005
17Fair hair (HP:0002286)3.80029138
18Congenital stationary night blindness (HP:0007642)3.76476991
19Hyperactive renin-angiotensin system (HP:0000841)3.74398966
20Lip pit (HP:0100267)3.72356633
21Milia (HP:0001056)3.72269850
22Osteomalacia (HP:0002749)3.52833896
23Abnormality of macular pigmentation (HP:0008002)3.52478411
24Pancreatic fibrosis (HP:0100732)3.49019416
25Turricephaly (HP:0000262)3.48868737
26True hermaphroditism (HP:0010459)3.44870135
27Shallow orbits (HP:0000586)3.33498130
28Hypoplasia of dental enamel (HP:0006297)3.32551903
29Bronchomalacia (HP:0002780)3.29127763
30Generalized hypopigmentation of hair (HP:0011358)3.20893856
31Bony spicule pigmentary retinopathy (HP:0007737)3.17641809
32Labial hypoplasia (HP:0000066)3.14194928
33Bell-shaped thorax (HP:0001591)3.13741305
34Ulnar bowing (HP:0003031)3.12114262
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07990598
36Decreased central vision (HP:0007663)3.07119872
37Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03191001
38Abnormality of the distal phalanges of the toes (HP:0010182)3.03171518
39Abnormality of the renal cortex (HP:0011035)3.00093802
40Popliteal pterygium (HP:0009756)2.98636840
41Hyperventilation (HP:0002883)2.97292829
42Fragile skin (HP:0001030)2.96538447
43Pendular nystagmus (HP:0012043)2.89405178
44Central scotoma (HP:0000603)2.87404271
45Distal lower limb muscle weakness (HP:0009053)2.84129330
46Split foot (HP:0001839)2.81038718
47Severe visual impairment (HP:0001141)2.76270799
48Abnormality of the labia (HP:0000058)2.74202688
49Hypoplastic female external genitalia (HP:0012815)2.72618188
50Molar tooth sign on MRI (HP:0002419)2.72238246
51Abnormality of midbrain morphology (HP:0002418)2.72238246
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.71991741
53Absent/shortened dynein arms (HP:0200106)2.71991741
54Congenital sensorineural hearing impairment (HP:0008527)2.71621176
55Abnormality of the renal medulla (HP:0100957)2.71561075
56Abnormal rod and cone electroretinograms (HP:0008323)2.69315003
57Aplasia/Hypoplasia of the scapulae (HP:0006713)2.69243141
58Hypoplastic scapulae (HP:0000882)2.69243141
59Cupped ear (HP:0000378)2.68502626
60Atrophic scars (HP:0001075)2.67391825
61Hyperkalemia (HP:0002153)2.64638501
62Amelogenesis imperfecta (HP:0000705)2.60879082
63Interstitial pulmonary disease (HP:0006530)2.60748690
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60119243
65Alacrima (HP:0000522)2.58523471
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.57311259
67Hypoplasia of the pons (HP:0012110)2.57285201
68Nephronophthisis (HP:0000090)2.55033319
69Abnormal respiratory motile cilium physiology (HP:0012261)2.54551840
70Glucose intolerance (HP:0000833)2.53563923
71Hypoplastic labia majora (HP:0000059)2.53468354
72Asymmetry of the thorax (HP:0001555)2.52995146
73Abnormal ciliary motility (HP:0012262)2.52755906
74Cystic liver disease (HP:0006706)2.50982436
75Keratoconus (HP:0000563)2.47028533
76Increased corneal curvature (HP:0100692)2.47028533
77Esophageal varix (HP:0002040)2.46954190
78Tubular atrophy (HP:0000092)2.46739732
79Synostosis involving bones of the lower limbs (HP:0009138)2.46177468
80Synostosis involving bones of the feet (HP:0009140)2.46177468
81Horizontal nystagmus (HP:0000666)2.45041017
82Febrile seizures (HP:0002373)2.43668474
83Hypoproteinemia (HP:0003075)2.42720493
84Clumsiness (HP:0002312)2.40664660
85Pigmentary retinal degeneration (HP:0001146)2.40201704
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.39554131
87Congenital hepatic fibrosis (HP:0002612)2.38740460
88Medial flaring of the eyebrow (HP:0010747)2.36220096
89Intestinal atresia (HP:0011100)2.35315921
90Abnormality of the labia majora (HP:0012881)2.34610573
91Tarsal synostosis (HP:0008368)2.34292226
92Submucous cleft hard palate (HP:0000176)2.33045743
93Albinism (HP:0001022)2.31747127
94Inability to walk (HP:0002540)2.28055570
95Focal seizures (HP:0007359)2.27694917
96Short nail (HP:0001799)2.27672212
97Protruding tongue (HP:0010808)2.27578820
98Tubulointerstitial nephritis (HP:0001970)2.26895140
99Abnormality of the pons (HP:0007361)2.26780016
100Choanal stenosis (HP:0000452)2.25781855
101Abnormality of the nasal septum (HP:0000419)2.24306990
102Portal hypertension (HP:0001409)2.23361867
103Upper limb muscle weakness (HP:0003484)2.22901134
104Aplasia/Hypoplasia of the fovea (HP:0008060)2.22144255
105Hypoplasia of the fovea (HP:0007750)2.22144255
106Abnormal hemoglobin (HP:0011902)2.22128867
107Abnormality of the hepatic vasculature (HP:0006707)2.21981299
108Cerebellar dysplasia (HP:0007033)2.21381643
109Abnormality of incisor morphology (HP:0011063)2.18305553
110Decreased circulating renin level (HP:0003351)2.16454428
111Dialeptic seizures (HP:0011146)2.15540643
112Micronodular cirrhosis (HP:0001413)2.15224894
113Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13540992
114Retinitis pigmentosa (HP:0000510)2.13332729
115Absent speech (HP:0001344)2.12922103
116Abolished electroretinogram (ERG) (HP:0000550)2.12311400
117Type II lissencephaly (HP:0007260)2.11356057
118Genital tract atresia (HP:0001827)2.09924123
119Macular degeneration (HP:0000608)2.09024888
120Abnormal respiratory motile cilium morphology (HP:0005938)2.08991909
121Abnormal respiratory epithelium morphology (HP:0012253)2.08991909
122Increased IgE level (HP:0003212)2.08113832
123Renal cortical cysts (HP:0000803)2.07517650
124Toxemia of pregnancy (HP:0100603)2.06565794
125Increased connective tissue (HP:0009025)2.04387594
126Progressive inability to walk (HP:0002505)2.04055878
127Abnormal drinking behavior (HP:0030082)2.02714689
128Polydipsia (HP:0001959)2.02714689
129Natal tooth (HP:0000695)2.02421149
130Thyroid-stimulating hormone excess (HP:0002925)2.01931798
131Aplasia/Hypoplasia of the tibia (HP:0005772)2.00529070
132Abnormality of the middle phalanges of the hand (HP:0009833)1.99168285
133Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98801215
134Renal salt wasting (HP:0000127)1.98760710
135Sleep apnea (HP:0010535)1.98708343
136Overriding aorta (HP:0002623)1.98451089
137Constricted visual fields (HP:0001133)1.98357551
138Sclerocornea (HP:0000647)1.95517182
139Oligodactyly (hands) (HP:0001180)1.95229735
140Nasolacrimal duct obstruction (HP:0000579)1.94894420
141Hyperlipoproteinemia (HP:0010980)1.94791823
142Tibial bowing (HP:0002982)1.94774995
143Vaginal atresia (HP:0000148)1.94432911
144Germ cell neoplasia (HP:0100728)1.93109657
145Distal lower limb amyotrophy (HP:0008944)1.93039554
146Furrowed tongue (HP:0000221)1.92601327
147Symphalangism affecting the phalanges of the hand (HP:0009773)1.92512590
148Chronic bronchitis (HP:0004469)1.92049661
149Abnormal glucose tolerance (HP:0001952)1.91199668
150Congenital primary aphakia (HP:0007707)1.91186412
151Photophobia (HP:0000613)1.90939008
152Osteolytic defects of the hand bones (HP:0009699)1.90927800
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.90927800
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.89730474
155Bowed forearm bones (HP:0003956)1.89679016
156Bowing of the arm (HP:0006488)1.89679016
157Gait imbalance (HP:0002141)1.89449316
158Confusion (HP:0001289)1.88558874
159Mixed hearing impairment (HP:0000410)1.87204577
160Anencephaly (HP:0002323)1.87076093
161Astigmatism (HP:0000483)1.86029958
162Preaxial foot polydactyly (HP:0001841)1.85266009
163Bifid scrotum (HP:0000048)1.84616734
164Esophageal atresia (HP:0002032)1.83632381
165Increased circulating renin level (HP:0000848)1.82642727
166Advanced eruption of teeth (HP:0006288)1.82483160
167Scotoma (HP:0000575)1.82107751
168Pterygium (HP:0001059)1.81172345
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80461946
170Premature rupture of membranes (HP:0001788)1.80148112
171Fragile nails (HP:0001808)1.79917934
172Abnormality of the fibula (HP:0002991)1.79805398
173Aplasia/Hypoplasia of the macula (HP:0008059)1.78822572
174Hypoplastic iliac wings (HP:0002866)1.78311550
175Small hand (HP:0200055)1.77340390
176Hypoplastic nipples (HP:0002557)1.76198445
177Increased cerebral lipofuscin (HP:0011813)1.76102021
178Facial diplegia (HP:0001349)1.76071900
179Tubulointerstitial abnormality (HP:0001969)1.75780522
180Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73982049
181Abnormality of the gastric mucosa (HP:0004295)1.73876201
182Abnormality of the fovea (HP:0000493)1.72947028
183Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.71753389
184Nephrogenic diabetes insipidus (HP:0009806)1.71463432
185Lower limb amyotrophy (HP:0007210)1.70249733
186Arnold-Chiari malformation (HP:0002308)1.69135649
187Alopecia of scalp (HP:0002293)1.67666752
188Down-sloping shoulders (HP:0200021)1.67171309
189Femoral bowing (HP:0002980)1.67116504
190Hypercalciuria (HP:0002150)1.66326148
191Abnormality of the 2nd finger (HP:0004100)1.65903393
192Short clavicles (HP:0000894)1.65856891
193Breast carcinoma (HP:0003002)1.65169434
194Hyperaldosteronism (HP:0000859)1.60566785
195Abnormality of the parietal bone (HP:0002696)1.60198371
196Abnormality of the middle phalanges of the toes (HP:0010183)1.59636751
197Coronal craniosynostosis (HP:0004440)1.58872740
198Plantar hyperkeratosis (HP:0007556)1.58539901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA35.66278033
2DAPK24.20891978
3EPHB13.58320211
4EPHA23.36049477
5FER3.11373501
6MAP4K23.03421699
7MAP3K22.85410798
8STK38L2.74334858
9ACVR1B2.63212772
10RPS6KB22.59533200
11MAP3K32.49166576
12FGFR42.38870951
13ERBB32.33986671
14BLK2.28600734
15EPHB22.27460699
16MST1R2.17363045
17ADRBK22.12605644
18HIPK21.99444556
19FGFR21.98489900
20LATS11.98280752
21WNK31.93741409
22TNK21.89303551
23FRK1.81007785
24PIK3CA1.72032143
25OXSR11.70480847
26INSRR1.70175008
27STK391.67529254
28CDK61.65595225
29SIK11.64281127
30PTK2B1.62657535
31PIK3CG1.62490760
32ALK1.60978838
33NLK1.58338998
34STK381.56536873
35TIE11.48788185
36PLK21.46770164
37TXK1.42058488
38IRAK11.39635625
39PDK21.36195571
40PLK41.36137885
41BCR1.32260445
42MAP3K41.28710498
43ERBB21.28407993
44MAPK131.26354751
45LMTK21.24135891
46GRK11.23051728
47MAPK151.22712385
48CAMK1D1.22365776
49TAOK31.20885406
50NUAK11.19760452
51MST41.19358822
52FGFR31.17969208
53BRD41.16491847
54PDK11.09099266
55WNK41.04804042
56ZAK1.03529020
57PKN11.03306124
58MKNK21.03093358
59PDGFRB1.01311806
60MAP2K21.00776912
61CAMKK20.98664374
62PTK20.96729835
63TEC0.94991515
64MELK0.93730349
65MAP3K120.93198283
66NME10.90970568
67PNCK0.90104788
68BMX0.89030026
69STK30.88932045
70MAP3K90.86632554
71PRKCE0.85756940
72PDPK10.84891019
73EPHA40.84547735
74MAP3K10.83536341
75PRPF4B0.82541235
76WEE10.81681341
77SGK20.81537705
78NEK60.81410772
79JAK10.80760761
80BMPR1B0.79209349
81CDK120.73443368
82PRKAA20.73014982
83CASK0.71842557
84CDK30.71646047
85PINK10.70766065
86EIF2AK30.70701615
87SGK30.70091763
88MARK10.69432468
89CDC42BPA0.68279866
90CDK80.68221877
91SGK2230.68032984
92SGK4940.68032984
93DYRK20.67073770
94TRPM70.64735901
95WNK10.64473642
96CAMK40.63670231
97MET0.60991725
98BRSK20.60180383
99PAK30.59381763
100MAPKAPK30.59207953
101KDR0.57643194
102BMPR20.57624004
103LATS20.57565689
104CAMK10.56169500
105NTRK30.55579152
106MAPKAPK50.55509896
107MAP2K10.55002341
108TGFBR10.54703464
109PRKCG0.54248757
110GRK60.54137554
111MAPKAPK20.52609219
112CAMK1G0.52113354
113ERBB40.49352778
114CAMK2B0.45106848
115MAP3K110.44589388
116GRK50.44217901
117CAMK2A0.43885979
118MARK30.43813891
119CAMK2D0.41932276
120STK100.41561092
121MATK0.41345556
122IKBKB0.39191608
123CDK190.39138900
124KIT0.38693374
125PTK60.38526948
126PRKD10.37255287
127CHEK20.35798252
128PLK10.35772262
129PLK30.35292935
130GSK3A0.34308145
131NEK20.34098178
132RET0.34096190
133PRKCZ0.33872771
134IGF1R0.33690415
135PRKCQ0.33632890
136ROCK20.32248684
137ROCK10.31665243
138GRK70.31497360
139PRKCI0.30982812
140MKNK10.30576538
141MAP2K70.29830789
142KSR10.29293353
143CSNK1G20.28506016
144TAOK10.28257094
145PRKACA0.28108227
146MAP3K70.28054645
147CSNK1A10.27792070
148CDK90.27718204
149CSNK1D0.26347108
150GSK3B0.26217399
151ITK0.25164243
152TSSK60.24784564
153MINK10.24725947
154FGFR10.24353273
155TGFBR20.24278281
156INSR0.24184937
157ADRBK10.24026396
158CDK50.23695859
159CHUK0.23620060
160ATR0.23594650
161SRC0.23455396
162FYN0.23336920
163MTOR0.23327738
164CSNK1A1L0.23266163
165PRKAA10.21463079
166PRKCA0.19811227

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.48581375
2Sulfur metabolism_Homo sapiens_hsa009203.58782068
3Phototransduction_Homo sapiens_hsa047442.84212052
4Butanoate metabolism_Homo sapiens_hsa006502.71009734
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.69242685
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.63729612
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.43530284
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39304885
9Tryptophan metabolism_Homo sapiens_hsa003802.23371811
10ABC transporters_Homo sapiens_hsa020102.20400578
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.13053685
12Propanoate metabolism_Homo sapiens_hsa006402.09925469
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04914185
14Homologous recombination_Homo sapiens_hsa034402.03046690
15Chemical carcinogenesis_Homo sapiens_hsa052041.99403265
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93877461
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.93006030
18Gastric acid secretion_Homo sapiens_hsa049711.87533105
19Nitrogen metabolism_Homo sapiens_hsa009101.78407146
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77134185
21Taste transduction_Homo sapiens_hsa047421.61183434
22Sulfur relay system_Homo sapiens_hsa041221.58909193
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57880671
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51608965
25Selenocompound metabolism_Homo sapiens_hsa004501.49874347
26Vibrio cholerae infection_Homo sapiens_hsa051101.47255312
27Glycerolipid metabolism_Homo sapiens_hsa005611.38917454
28Lysine degradation_Homo sapiens_hsa003101.36628445
29ECM-receptor interaction_Homo sapiens_hsa045121.36416519
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35142139
31Fatty acid degradation_Homo sapiens_hsa000711.33649961
32Collecting duct acid secretion_Homo sapiens_hsa049661.33165512
33Ovarian steroidogenesis_Homo sapiens_hsa049131.27725502
34Adherens junction_Homo sapiens_hsa045201.26844200
35Fatty acid biosynthesis_Homo sapiens_hsa000611.22870139
36Tight junction_Homo sapiens_hsa045301.19922419
37Regulation of autophagy_Homo sapiens_hsa041401.19624066
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16553806
39Fanconi anemia pathway_Homo sapiens_hsa034601.15951061
40Salivary secretion_Homo sapiens_hsa049701.15833002
41Hippo signaling pathway_Homo sapiens_hsa043901.15365036
42Non-homologous end-joining_Homo sapiens_hsa034501.10379586
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07520893
44Serotonergic synapse_Homo sapiens_hsa047261.05870204
45Bladder cancer_Homo sapiens_hsa052191.04691937
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97528447
47Proteoglycans in cancer_Homo sapiens_hsa052050.96019557
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95891645
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95724181
50Dilated cardiomyopathy_Homo sapiens_hsa054140.95623453
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95017452
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94844641
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.94570040
54Axon guidance_Homo sapiens_hsa043600.92954420
55Sphingolipid metabolism_Homo sapiens_hsa006000.92904049
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91727773
57Amoebiasis_Homo sapiens_hsa051460.91278665
58Synaptic vesicle cycle_Homo sapiens_hsa047210.91155225
59Fatty acid metabolism_Homo sapiens_hsa012120.90861364
60Melanogenesis_Homo sapiens_hsa049160.86629301
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86462535
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85897502
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.85076620
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84769502
65Wnt signaling pathway_Homo sapiens_hsa043100.82245337
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82185113
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.82021138
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.81952971
69TGF-beta signaling pathway_Homo sapiens_hsa043500.81600284
70Toxoplasmosis_Homo sapiens_hsa051450.80768393
71Rheumatoid arthritis_Homo sapiens_hsa053230.80678072
72Long-term potentiation_Homo sapiens_hsa047200.75846951
73Circadian entrainment_Homo sapiens_hsa047130.75008945
74Histidine metabolism_Homo sapiens_hsa003400.74742043
75PPAR signaling pathway_Homo sapiens_hsa033200.74529007
76Focal adhesion_Homo sapiens_hsa045100.73650090
77One carbon pool by folate_Homo sapiens_hsa006700.72936400
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71157719
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.70312359
80Acute myeloid leukemia_Homo sapiens_hsa052210.70182789
81Retinol metabolism_Homo sapiens_hsa008300.69291417
82Amphetamine addiction_Homo sapiens_hsa050310.67737561
83Melanoma_Homo sapiens_hsa052180.67526890
84Olfactory transduction_Homo sapiens_hsa047400.65767583
85Basal cell carcinoma_Homo sapiens_hsa052170.65499912
86beta-Alanine metabolism_Homo sapiens_hsa004100.64917275
87Prolactin signaling pathway_Homo sapiens_hsa049170.64233525
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63749927
89Peroxisome_Homo sapiens_hsa041460.63025147
90RNA polymerase_Homo sapiens_hsa030200.62730659
91Bile secretion_Homo sapiens_hsa049760.61945088
92Glutamatergic synapse_Homo sapiens_hsa047240.61033508
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60181156
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.60144124
95Viral myocarditis_Homo sapiens_hsa054160.60067855
96Cholinergic synapse_Homo sapiens_hsa047250.59902978
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59546087
98Ether lipid metabolism_Homo sapiens_hsa005650.59490121
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58321066
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58140116
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58063368
102Basal transcription factors_Homo sapiens_hsa030220.57104958
103African trypanosomiasis_Homo sapiens_hsa051430.56994767
104Tyrosine metabolism_Homo sapiens_hsa003500.56727108
105Renin secretion_Homo sapiens_hsa049240.56093321
106Glutathione metabolism_Homo sapiens_hsa004800.56048871
107cAMP signaling pathway_Homo sapiens_hsa040240.55625297
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55331526
109Rap1 signaling pathway_Homo sapiens_hsa040150.55286864
110ErbB signaling pathway_Homo sapiens_hsa040120.55274688
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54264182
112Pathways in cancer_Homo sapiens_hsa052000.53321333
113Estrogen signaling pathway_Homo sapiens_hsa049150.52672202
114Platelet activation_Homo sapiens_hsa046110.50758647
115Dorso-ventral axis formation_Homo sapiens_hsa043200.50205437
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49888026
117Complement and coagulation cascades_Homo sapiens_hsa046100.49842035
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49707349
119Pyruvate metabolism_Homo sapiens_hsa006200.49556677
120Phenylalanine metabolism_Homo sapiens_hsa003600.48396992
121Purine metabolism_Homo sapiens_hsa002300.48128469
122Pancreatic secretion_Homo sapiens_hsa049720.47702755
123Morphine addiction_Homo sapiens_hsa050320.47552367
124Nicotine addiction_Homo sapiens_hsa050330.47511725
125Oxytocin signaling pathway_Homo sapiens_hsa049210.46291641
126Fat digestion and absorption_Homo sapiens_hsa049750.45739639
127Thyroid hormone synthesis_Homo sapiens_hsa049180.45659759
128Linoleic acid metabolism_Homo sapiens_hsa005910.44784188
129Leishmaniasis_Homo sapiens_hsa051400.44565270
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44459862
131Influenza A_Homo sapiens_hsa051640.44409187
132Calcium signaling pathway_Homo sapiens_hsa040200.43822162
133Insulin resistance_Homo sapiens_hsa049310.43797460
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43365127
135Pancreatic cancer_Homo sapiens_hsa052120.41621474
136Arachidonic acid metabolism_Homo sapiens_hsa005900.40995042
137GABAergic synapse_Homo sapiens_hsa047270.40853830
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40590630
139Phagosome_Homo sapiens_hsa041450.40135166
140Primary immunodeficiency_Homo sapiens_hsa053400.40116815
141Ras signaling pathway_Homo sapiens_hsa040140.39821222
142Insulin secretion_Homo sapiens_hsa049110.39291682
143Circadian rhythm_Homo sapiens_hsa047100.39251787
144Mineral absorption_Homo sapiens_hsa049780.39019103
145Renal cell carcinoma_Homo sapiens_hsa052110.38629431
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37683379
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36996070
148Metabolic pathways_Homo sapiens_hsa011000.34002206
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30002840
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28048375
151Starch and sucrose metabolism_Homo sapiens_hsa005000.25942922
152N-Glycan biosynthesis_Homo sapiens_hsa005100.25346335
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24448560
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24061668
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22582947
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21910077

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