CCDC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.74176055
2acrosome reaction (GO:0007340)9.49805938
3epithelial cilium movement (GO:0003351)8.82820207
4piRNA metabolic process (GO:0034587)8.62427409
5sperm-egg recognition (GO:0035036)8.53222806
6multicellular organism reproduction (GO:0032504)8.52187502
7motile cilium assembly (GO:0044458)8.46770660
8acrosome assembly (GO:0001675)8.32133563
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.00614559
10cilium movement (GO:0003341)7.93650814
11plasma membrane fusion (GO:0045026)7.78941477
12cell wall macromolecule metabolic process (GO:0044036)7.71633133
13cell wall macromolecule catabolic process (GO:0016998)7.71633133
14binding of sperm to zona pellucida (GO:0007339)7.71607341
15spermatid development (GO:0007286)7.69686303
16cell-cell recognition (GO:0009988)7.63473769
17male meiosis (GO:0007140)7.51661023
18regulation of cilium movement (GO:0003352)7.19537218
19reproduction (GO:0000003)7.14272206
20synaptonemal complex organization (GO:0070193)7.00159938
21negative regulation of inclusion body assembly (GO:0090084)6.98045653
22synaptonemal complex assembly (GO:0007130)6.58973834
23sperm capacitation (GO:0048240)6.23840202
24central nervous system myelination (GO:0022010)6.21635307
25axon ensheathment in central nervous system (GO:0032291)6.21635307
26single fertilization (GO:0007338)6.04928726
27DNA methylation involved in gamete generation (GO:0043046)5.98034435
28fertilization (GO:0009566)5.39390244
29regulation of inclusion body assembly (GO:0090083)5.31004907
30rRNA catabolic process (GO:0016075)5.26288467
31spermatogenesis (GO:0007283)5.26231777
32male gamete generation (GO:0048232)5.24101476
33ventricular system development (GO:0021591)5.09409442
34male meiosis I (GO:0007141)4.93716194
35microtubule severing (GO:0051013)4.85772174
36gamete generation (GO:0007276)4.84276167
37regulation of microtubule-based movement (GO:0060632)4.83316129
38behavioral response to nicotine (GO:0035095)4.66464367
39calcium ion-dependent exocytosis (GO:0017156)4.66218477
40left/right pattern formation (GO:0060972)4.48536507
41protein localization to cilium (GO:0061512)4.45111711
42germ cell development (GO:0007281)4.38155966
43chromosome organization involved in meiosis (GO:0070192)4.35838031
44cellular process involved in reproduction in multicellular organism (GO:0022412)4.31355075
45cell recognition (GO:0008037)4.31004805
46microtubule depolymerization (GO:0007019)4.30625164
47meiotic nuclear division (GO:0007126)4.12721890
48organic cation transport (GO:0015695)4.09458574
49protein polyglutamylation (GO:0018095)4.06154445
50meiosis I (GO:0007127)3.98887118
51fatty acid elongation (GO:0030497)3.86886674
52intraciliary transport (GO:0042073)3.76012001
53meiotic cell cycle (GO:0051321)3.75110636
54multicellular organismal reproductive process (GO:0048609)3.73392414
55exogenous drug catabolic process (GO:0042738)3.68855103
56retinal cone cell development (GO:0046549)3.67904305
57adaptation of signaling pathway (GO:0023058)3.60253751
58response to methylmercury (GO:0051597)3.54389861
59axoneme assembly (GO:0035082)3.52240345
60cilium morphogenesis (GO:0060271)3.50896546
61microtubule polymerization or depolymerization (GO:0031109)3.44681699
62tryptophan catabolic process (GO:0006569)3.43651770
63indole-containing compound catabolic process (GO:0042436)3.43651770
64indolalkylamine catabolic process (GO:0046218)3.43651770
65regulation of memory T cell differentiation (GO:0043380)3.41375536
66spermatid nucleus differentiation (GO:0007289)3.38721656
67ensheathment of neurons (GO:0007272)3.37546904
68axon ensheathment (GO:0008366)3.37546904
69myelination (GO:0042552)3.36043146
70photoreceptor cell maintenance (GO:0045494)3.35846953
71drug catabolic process (GO:0042737)3.31293494
72regulation of germinal center formation (GO:0002634)3.27213037
73mesenchymal cell differentiation involved in renal system development (GO:2001012)3.22239058
74mesenchymal cell differentiation involved in kidney development (GO:0072161)3.22239058
75glycerol ether metabolic process (GO:0006662)3.21606848
76cilium organization (GO:0044782)3.18361597
77L-fucose catabolic process (GO:0042355)3.18204687
78fucose catabolic process (GO:0019317)3.18204687
79L-fucose metabolic process (GO:0042354)3.18204687
80microtubule-based movement (GO:0007018)3.17421195
81seminiferous tubule development (GO:0072520)3.16575493
82kynurenine metabolic process (GO:0070189)3.15921424
83cellular ketone body metabolic process (GO:0046950)3.14456060
84tolerance induction (GO:0002507)3.13307279
85indolalkylamine metabolic process (GO:0006586)3.10778824
86cilium assembly (GO:0042384)3.09075812
87regulation of hippo signaling (GO:0035330)3.08580912
88sphingoid metabolic process (GO:0046519)3.08307893
89positive regulation of T cell mediated cytotoxicity (GO:0001916)3.02921156
90protein K11-linked deubiquitination (GO:0035871)2.99985130
91DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.99529045
92ether metabolic process (GO:0018904)2.97928772
93multicellular organismal development (GO:0007275)2.95958057
94neurotransmitter metabolic process (GO:0042133)2.95698960
95positive regulation of defense response to virus by host (GO:0002230)2.94300169
96negative regulation of organelle assembly (GO:1902116)2.93720859
97cellular component assembly involved in morphogenesis (GO:0010927)2.93627548
98diol metabolic process (GO:0034311)2.90673309
99chaperone-mediated protein complex assembly (GO:0051131)2.87077199
100tryptophan metabolic process (GO:0006568)2.85408260
101negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85360330
102negative regulation of B cell mediated immunity (GO:0002713)2.85360330
103protein refolding (GO:0042026)2.85258716
104detection of light stimulus involved in visual perception (GO:0050908)2.84538066
105detection of light stimulus involved in sensory perception (GO:0050962)2.84538066
106single strand break repair (GO:0000012)2.84201344
107negative regulation of T cell differentiation in thymus (GO:0033085)2.82026047
108NAD biosynthetic process (GO:0009435)2.82003211
109sphingosine metabolic process (GO:0006670)2.81937427
110centriole replication (GO:0007099)2.80800118
111regulation of spindle checkpoint (GO:0090231)2.78164498
112response to pheromone (GO:0019236)2.77926648
113negative regulation of telomere maintenance (GO:0032205)2.77724902
114long-chain fatty acid biosynthetic process (GO:0042759)2.77529119
115detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77276367
116neural tube formation (GO:0001841)2.75364429
117myelin maintenance (GO:0043217)2.75028949
118ketone body metabolic process (GO:1902224)2.72729135
119regulation of mesoderm development (GO:2000380)2.72679335
120genitalia morphogenesis (GO:0035112)2.72539911
121alditol metabolic process (GO:0019400)2.72132075
122sleep (GO:0030431)2.66416561
123regulation of response to osmotic stress (GO:0047484)2.65436768
124positive regulation of meiosis (GO:0045836)2.65364492
125centriole assembly (GO:0098534)2.65267735
126regulation of T cell mediated cytotoxicity (GO:0001914)2.64442333
127negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64316849
128DNA damage response, signal transduction resulting in transcription (GO:0042772)2.62711528
129nucleoside diphosphate phosphorylation (GO:0006165)2.62476637
130regulation of meiosis I (GO:0060631)2.58679677
131cell projection assembly (GO:0030031)2.57609891
132detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.57541411
133neurotransmitter biosynthetic process (GO:0042136)2.56897251
134benzene-containing compound metabolic process (GO:0042537)2.56414608
135ncRNA catabolic process (GO:0034661)2.55203444
136synapsis (GO:0007129)2.54420482
137one-carbon compound transport (GO:0019755)2.53358589
138regulation of defense response to virus by host (GO:0050691)2.52268986
139regulation of cytokine production involved in inflammatory response (GO:1900015)2.51619840
140eye photoreceptor cell differentiation (GO:0001754)2.50326412
141photoreceptor cell differentiation (GO:0046530)2.50326412
142negative regulation of skeletal muscle tissue development (GO:0048642)2.49787160
143protein K48-linked deubiquitination (GO:0071108)2.49473662
144chromosome condensation (GO:0030261)2.49463962
145positive regulation of meiotic cell cycle (GO:0051446)2.49264049
146glycerol metabolic process (GO:0006071)2.49073214
147auditory receptor cell stereocilium organization (GO:0060088)2.48749919
148phosphatidylethanolamine biosynthetic process (GO:0006646)2.48666345
149indole-containing compound metabolic process (GO:0042430)2.48003816
150appendage development (GO:0048736)2.47855371
151limb development (GO:0060173)2.47855371
152gene silencing by RNA (GO:0031047)2.45929007
153positive regulation of oligodendrocyte differentiation (GO:0048714)2.44870078
154microtubule bundle formation (GO:0001578)2.44826396
155DNA packaging (GO:0006323)2.44036988
156membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43553373
157sex differentiation (GO:0007548)2.41938258
158left/right axis specification (GO:0070986)2.41598145
159meiotic cell cycle process (GO:1903046)2.40741446
160phosphatidylethanolamine metabolic process (GO:0046337)2.40474832
161response to xenobiotic stimulus (GO:0009410)2.40313410
162spinal cord motor neuron differentiation (GO:0021522)2.39298760
163cornea development in camera-type eye (GO:0061303)2.39292458
164cellular response to exogenous dsRNA (GO:0071360)2.38204163
165cilium or flagellum-dependent cell motility (GO:0001539)11.4598586
166sperm motility (GO:0030317)10.4215312
167fusion of sperm to egg plasma membrane (GO:0007342)10.2783469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.29238379
2EZH2_22144423_ChIP-Seq_EOC_Human5.90281147
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.89995642
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.62053143
5GATA1_26923725_Chip-Seq_HPCs_Mouse2.24062832
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15531677
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06198482
8IGF1R_20145208_ChIP-Seq_DFB_Human2.04832926
9VDR_22108803_ChIP-Seq_LS180_Human1.93496178
10IRF8_22096565_ChIP-ChIP_GC-B_Human1.91467663
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87686351
12* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.77566178
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75205687
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.68509752
15AR_21572438_ChIP-Seq_LNCaP_Human1.67226851
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.67098539
17ZNF274_21170338_ChIP-Seq_K562_Hela1.65924752
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60645667
19NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59880554
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.59402986
21* REST_21632747_ChIP-Seq_MESCs_Mouse1.58250420
22TAF15_26573619_Chip-Seq_HEK293_Human1.57842424
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57162888
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57070224
25P300_19829295_ChIP-Seq_ESCs_Human1.53251060
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.51779796
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49671140
28MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49010510
29BCAT_22108803_ChIP-Seq_LS180_Human1.48520304
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.47288829
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43669390
32TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42516706
33GBX2_23144817_ChIP-Seq_PC3_Human1.42295388
34IRF1_19129219_ChIP-ChIP_H3396_Human1.42255468
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42211757
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41981720
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38777122
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37619426
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36806797
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35926590
41CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35265872
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34904030
43AR_25329375_ChIP-Seq_VCAP_Human1.33859181
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32446788
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32046642
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31803819
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29867108
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.29825278
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29790105
50KDM2B_26808549_Chip-Seq_REH_Human1.28475947
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.27409285
52RUNX2_22187159_ChIP-Seq_PCA_Human1.27318443
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27162763
54TCF4_22108803_ChIP-Seq_LS180_Human1.25585501
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25548748
56EWS_26573619_Chip-Seq_HEK293_Human1.24503125
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23306947
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23219947
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23098959
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22841091
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22429474
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21816686
63TP53_22573176_ChIP-Seq_HFKS_Human1.21132285
64NANOG_19829295_ChIP-Seq_ESCs_Human1.19848439
65SOX2_19829295_ChIP-Seq_ESCs_Human1.19848439
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18484279
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.18477727
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18477727
69AHR_22903824_ChIP-Seq_MCF-7_Human1.17646273
70AR_20517297_ChIP-Seq_VCAP_Human1.17357511
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16965223
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16793648
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16785189
74RNF2_27304074_Chip-Seq_NSC_Mouse1.16301874
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.15888889
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.15710787
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15373788
78ER_23166858_ChIP-Seq_MCF-7_Human1.14001287
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13938706
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13938706
81NCOR_22424771_ChIP-Seq_293T_Human1.13092494
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13061071
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12923879
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.12477659
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.12402273
86STAT1_17558387_ChIP-Seq_HELA_Human1.11247010
87OCT1_27270436_Chip-Seq_PROSTATE_Human1.10581553
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10491657
89* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09710525
90DROSHA_22980978_ChIP-Seq_HELA_Human1.09194622
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08734727
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08705899
93OCT4_20526341_ChIP-Seq_ESCs_Human1.08423427
94GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.08111260
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07074084
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.06947782
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06904139
98CBP_20019798_ChIP-Seq_JUKART_Human1.06904139
99SOX2_22085726_ChIP-Seq_NPCs_Mouse1.06316385
100WDR5_24793694_ChIP-Seq_LNCAP_Human1.05645074
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05504081
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05475079
103SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04797527
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04751450
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.04698836
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.04660616
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04657495
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.04632325
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03890796
110FUS_26573619_Chip-Seq_HEK293_Human1.03344842
111HOXB7_26014856_ChIP-Seq_BT474_Human1.03021984
112P300_18555785_Chip-Seq_ESCs_Mouse1.03012246
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02365181
114SOX9_26525672_Chip-Seq_HEART_Mouse1.01728837
115SMRT_27268052_Chip-Seq_Bcells_Human1.01387092
116P53_22387025_ChIP-Seq_ESCs_Mouse1.01317632
117* GATA3_26560356_Chip-Seq_TH2_Human1.01228922
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00452709
119TCF4_23295773_ChIP-Seq_U87_Human1.00060858
120MYC_19829295_ChIP-Seq_ESCs_Human0.99672887
121* NANOG_20526341_ChIP-Seq_ESCs_Human0.99286667
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99242269
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98907494
124TBL1_22424771_ChIP-Seq_293T_Human0.98258536
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.98064453
126ETV1_20927104_ChIP-Seq_GIST48_Human0.98059528
127GF1_26923725_Chip-Seq_HPCs_Mouse0.98031041
128CDX2_22108803_ChIP-Seq_LS180_Human0.97979208
129P53_21459846_ChIP-Seq_SAOS-2_Human0.97188218
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96884188
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96738233
132KLF4_18555785_Chip-Seq_ESCs_Mouse0.96621012
133RXR_22108803_ChIP-Seq_LS180_Human0.95984973
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95924122
135ERA_21632823_ChIP-Seq_H3396_Human0.95304277
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94928332
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94575258
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94527049
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.93968412
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93846261
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93366961
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93357676
143TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93151412
144SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92765600
145GATA3_21867929_ChIP-Seq_CD8_Mouse0.92068388
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.91975280
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.91732223
148* FOXH1_21741376_ChIP-Seq_EPCs_Human0.91643666
149* SMAD4_21799915_ChIP-Seq_A2780_Human0.91300478
150REST_18959480_ChIP-ChIP_MESCs_Mouse0.91244033
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.90759766
152CTCF_20526341_ChIP-Seq_ESCs_Human0.90742933
153RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90719420
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.89122770
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.89059898
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88295577
157NFYB_21822215_ChIP-Seq_K562_Human0.88103409
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87797088
159STAT3_23295773_ChIP-Seq_U87_Human0.87384970
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85819836
161OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85212292
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85187242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.74308148
2MP0001929_abnormal_gametogenesis4.19758667
3MP0008877_abnormal_DNA_methylation4.14030518
4MP0003195_calcinosis3.30768715
5MP0003646_muscle_fatigue3.10957691
6MP0008875_abnormal_xenobiotic_pharmacok2.93450767
7MP0002653_abnormal_ependyma_morphology2.89557815
8MP0002210_abnormal_sex_determination2.76175608
9MP0000920_abnormal_myelination2.71323678
10MP0002161_abnormal_fertility/fecundity2.58824643
11MP0001145_abnormal_male_reproductive2.32685439
12MP0003880_abnormal_central_pattern2.19583771
13MP0000569_abnormal_digit_pigmentation2.18437855
14MP0005623_abnormal_meninges_morphology2.10363651
15MP0003879_abnormal_hair_cell2.07729735
16MP0005646_abnormal_pituitary_gland2.05417207
17MP0003950_abnormal_plasma_membrane2.04506423
18MP0004270_analgesia2.03497329
19MP0005410_abnormal_fertilization12.0552996
20MP0000653_abnormal_sex_gland1.98205486
21MP0001501_abnormal_sleep_pattern1.93112944
22MP0002876_abnormal_thyroid_physiology1.92901970
23MP0009780_abnormal_chondrocyte_physiolo1.85621146
24MP0003329_amyloid_beta_deposits1.82912115
25MP0003136_yellow_coat_color1.78440463
26MP0005171_absent_coat_pigmentation1.73236111
27MP0008872_abnormal_physiological_respon1.71646848
28MP0005167_abnormal_blood-brain_barrier1.70265763
29MP0003045_fibrosis1.70075398
30MP0002837_dystrophic_cardiac_calcinosis1.66046633
31MP0004742_abnormal_vestibular_system1.62384447
32MP0001529_abnormal_vocalization1.61938306
33MP0002272_abnormal_nervous_system1.60045569
34MP0003634_abnormal_glial_cell1.59184948
35MP0002160_abnormal_reproductive_system1.58966749
36MP0005671_abnormal_response_to1.58180880
37MP0005670_abnormal_white_adipose1.52602146
38MP0009697_abnormal_copulation1.51709096
39MP0009046_muscle_twitch1.50912868
40MP0000778_abnormal_nervous_system1.48062492
41MP0001486_abnormal_startle_reflex1.45113903
42MP0004885_abnormal_endolymph1.44650729
43MP0002638_abnormal_pupillary_reflex1.43848532
44MP0004133_heterotaxia1.42602583
45MP0002168_other_aberrant_phenotype1.38015907
46MP0005645_abnormal_hypothalamus_physiol1.36704193
47MP0004859_abnormal_synaptic_plasticity1.32841666
48MP0001986_abnormal_taste_sensitivity1.32516477
49MP0000427_abnormal_hair_cycle1.31993531
50MP0001664_abnormal_digestion1.31233682
51MP0005310_abnormal_salivary_gland1.28303038
52MP0002138_abnormal_hepatobiliary_system1.24908449
53MP0003690_abnormal_glial_cell1.24449474
54MP0002064_seizures1.22331861
55MP0010386_abnormal_urinary_bladder1.20535730
56MP0000685_abnormal_immune_system1.20341041
57MP0000955_abnormal_spinal_cord1.16853698
58MP0006276_abnormal_autonomic_nervous1.15326127
59MP0004134_abnormal_chest_morphology1.13763090
60MP0003635_abnormal_synaptic_transmissio1.12319809
61MP0005551_abnormal_eye_electrophysiolog1.11317279
62MP0002229_neurodegeneration1.11212091
63MP0001485_abnormal_pinna_reflex1.10837311
64MP0000631_abnormal_neuroendocrine_gland1.09859444
65MP0002132_abnormal_respiratory_system1.09225549
66MP0002736_abnormal_nociception_after1.07181687
67MP0001919_abnormal_reproductive_system1.07074783
68MP0001984_abnormal_olfaction1.05798566
69MP0001905_abnormal_dopamine_level1.04698062
70MP0000462_abnormal_digestive_system1.04479620
71MP0002928_abnormal_bile_duct1.03680998
72MP0002282_abnormal_trachea_morphology1.03533290
73MP0004142_abnormal_muscle_tone0.99554265
74MP0005085_abnormal_gallbladder_physiolo0.99407813
75MP0002572_abnormal_emotion/affect_behav0.99374289
76MP0002882_abnormal_neuron_morphology0.99116055
77MP0002063_abnormal_learning/memory/cond0.98602987
78MP0003631_nervous_system_phenotype0.98082324
79MP0002733_abnormal_thermal_nociception0.97516462
80MP0003011_delayed_dark_adaptation0.97423732
81MP0002734_abnormal_mechanical_nocicepti0.97368015
82MP0003632_abnormal_nervous_system0.97356260
83MP0004147_increased_porphyrin_level0.96051996
84MP0003633_abnormal_nervous_system0.94736031
85MP0000230_abnormal_systemic_arterial0.93921352
86MP0001968_abnormal_touch/_nociception0.93648939
87MP0005423_abnormal_somatic_nervous0.92780085
88MP0000049_abnormal_middle_ear0.92624248
89MP0004130_abnormal_muscle_cell0.92047775
90MP0003878_abnormal_ear_physiology0.91787433
91MP0005377_hearing/vestibular/ear_phenot0.91787433
92MP0002148_abnormal_hypersensitivity_rea0.91393541
93MP0009745_abnormal_behavioral_response0.89648785
94MP0004084_abnormal_cardiac_muscle0.89213408
95MP0002277_abnormal_respiratory_mucosa0.87634528
96MP0009764_decreased_sensitivity_to0.85714342
97MP0005395_other_phenotype0.85672956
98MP0002152_abnormal_brain_morphology0.85671891
99MP0001440_abnormal_grooming_behavior0.84774349
100MP0008789_abnormal_olfactory_epithelium0.84048664
101MP0001873_stomach_inflammation0.83531561
102MP0001790_abnormal_immune_system0.82881375
103MP0005387_immune_system_phenotype0.82881375
104MP0005451_abnormal_body_composition0.82760687
105MP0005360_urolithiasis0.81676689
106MP0002752_abnormal_somatic_nervous0.81162302
107MP0005253_abnormal_eye_physiology0.79518567
108MP0002067_abnormal_sensory_capabilities0.78305425
109MP0008569_lethality_at_weaning0.77611680
110MP0005075_abnormal_melanosome_morpholog0.77576912
111MP0002066_abnormal_motor_capabilities/c0.77437688
112MP0003861_abnormal_nervous_system0.76065488
113MP0005174_abnormal_tail_pigmentation0.75903344
114MP0001293_anophthalmia0.75317597
115MP0004381_abnormal_hair_follicle0.74620988
116MP0003183_abnormal_peptide_metabolism0.74609952
117MP0005365_abnormal_bile_salt0.74457836
118MP0004019_abnormal_vitamin_homeostasis0.74449169
119MP0001835_abnormal_antigen_presentation0.73492544
120MP0008995_early_reproductive_senescence0.73275729
121MP0000604_amyloidosis0.71342766
122MP0001963_abnormal_hearing_physiology0.71273252
123MP0004043_abnormal_pH_regulation0.70509712
124MP0000537_abnormal_urethra_morphology0.70432089
125MP0005195_abnormal_posterior_eye0.68380334
126MP0004811_abnormal_neuron_physiology0.66759811
127MP0001299_abnormal_eye_distance/0.66446833
128MP0004036_abnormal_muscle_relaxation0.65094229
129MP0005391_vision/eye_phenotype0.64737008
130MP0004233_abnormal_muscle_weight0.64150974
131MP0000566_synostosis0.62982924
132MP0001765_abnormal_ion_homeostasis0.62486167
133MP0002234_abnormal_pharynx_morphology0.62335524
134MP0000026_abnormal_inner_ear0.62256259
135MP0000647_abnormal_sebaceous_gland0.61636048
136MP0002557_abnormal_social/conspecific_i0.60760282
137MP0002735_abnormal_chemical_nociception0.60554126
138MP0000749_muscle_degeneration0.59871757
139MP0000534_abnormal_ureter_morphology0.59062759
140MP0006072_abnormal_retinal_apoptosis0.58658354
141MP0008057_abnormal_DNA_replication0.58523130
142MP0005647_abnormal_sex_gland0.58272772
143MP0000383_abnormal_hair_follicle0.56442890
144MP0001970_abnormal_pain_threshold0.56376056
145MP0010678_abnormal_skin_adnexa0.55649202
146MP0000372_irregular_coat_pigmentation0.55625424
147MP0005389_reproductive_system_phenotype0.55389902
148MP0002295_abnormal_pulmonary_circulatio0.54070405
149MP0008058_abnormal_DNA_repair0.52847419
150MP0002102_abnormal_ear_morphology0.51932036
151MP0001324_abnormal_eye_pigmentation0.51656380
152MP0005409_darkened_coat_color0.51058522
153MP0004145_abnormal_muscle_electrophysio0.49560557

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.38548687
2Abnormal respiratory motile cilium morphology (HP:0005938)7.94371767
3Abnormal respiratory epithelium morphology (HP:0012253)7.94371767
4Abnormal ciliary motility (HP:0012262)6.94111817
5Rhinitis (HP:0012384)6.90169360
6Chronic bronchitis (HP:0004469)5.71192095
7Infertility (HP:0000789)5.30068377
8Pancreatic cysts (HP:0001737)4.48425200
9Nasal polyposis (HP:0100582)4.28612694
10Nephronophthisis (HP:0000090)4.17151660
11Neurofibrillary tangles (HP:0002185)3.76990504
12Bronchiectasis (HP:0002110)3.71102777
13Chronic hepatic failure (HP:0100626)3.46240554
14Male infertility (HP:0003251)3.42970769
15Cystic liver disease (HP:0006706)3.41777398
16Abnormality of the nasal mucosa (HP:0000433)3.35233065
17Bilateral microphthalmos (HP:0007633)3.23108267
18Attenuation of retinal blood vessels (HP:0007843)3.22918573
19Aplasia/Hypoplasia of the fovea (HP:0008060)3.17327939
20Hypoplasia of the fovea (HP:0007750)3.17327939
21Decreased circulating renin level (HP:0003351)3.13231297
22Chronic sinusitis (HP:0011109)3.09787124
23Occipital encephalocele (HP:0002085)3.08175615
24Abnormality of the renal medulla (HP:0100957)3.06196510
25Unilateral renal agenesis (HP:0000122)3.05570267
26Bronchitis (HP:0012387)3.00808955
27Decreased central vision (HP:0007663)3.00126108
28Congenital stationary night blindness (HP:0007642)2.98222075
29Medial flaring of the eyebrow (HP:0010747)2.97695613
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95976107
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.95976107
32Tubulointerstitial nephritis (HP:0001970)2.94657169
33Cerebral inclusion bodies (HP:0100314)2.78957356
34Fibular aplasia (HP:0002990)2.77309968
35Abnormality of the fovea (HP:0000493)2.72694258
36Molar tooth sign on MRI (HP:0002419)2.68413968
37Abnormality of midbrain morphology (HP:0002418)2.68413968
38Abnormal rod and cone electroretinograms (HP:0008323)2.60656421
39Abnormality of the renal cortex (HP:0011035)2.59831487
40Bony spicule pigmentary retinopathy (HP:0007737)2.55024311
41Sensory axonal neuropathy (HP:0003390)2.51982140
42Spastic tetraparesis (HP:0001285)2.49788132
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43762128
44Recurrent otitis media (HP:0000403)2.43267915
45Peripheral hypomyelination (HP:0007182)2.42125821
46Sclerocornea (HP:0000647)2.42071591
47Anencephaly (HP:0002323)2.38782263
48Broad distal phalanx of finger (HP:0009836)2.35669154
49Gonadotropin excess (HP:0000837)2.35371658
50Abnormality of the lower motor neuron (HP:0002366)2.33046772
51Abnormality of macular pigmentation (HP:0008002)2.32109024
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.30765478
53Supranuclear gaze palsy (HP:0000605)2.28910877
54Amyotrophic lateral sclerosis (HP:0007354)2.27743457
55Abnormality of the corticospinal tract (HP:0002492)2.26395371
56Male pseudohermaphroditism (HP:0000037)2.25907911
57Abolished electroretinogram (ERG) (HP:0000550)2.23611949
58Tubular atrophy (HP:0000092)2.22507245
59Retinal dysplasia (HP:0007973)2.21917444
60Tubulointerstitial abnormality (HP:0001969)2.16570249
61Gait imbalance (HP:0002141)2.14051793
62Aplasia/Hypoplasia of the fibula (HP:0006492)2.11526439
63Abnormality of the dental root (HP:0006486)2.10035572
64Taurodontia (HP:0000679)2.10035572
65Abnormality of permanent molar morphology (HP:0011071)2.10035572
66Chronic otitis media (HP:0000389)2.07814706
67Bell-shaped thorax (HP:0001591)2.07661528
68Congenital primary aphakia (HP:0007707)2.07337548
69Gaze-evoked nystagmus (HP:0000640)2.06456146
70Recurrent sinusitis (HP:0011108)2.06218684
71Postaxial foot polydactyly (HP:0001830)2.03585707
72Fibular hypoplasia (HP:0003038)2.02484218
73Furrowed tongue (HP:0000221)2.02193037
74Onion bulb formation (HP:0003383)2.01715109
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.1702365
76Dynein arm defect of respiratory motile cilia (HP:0012255)10.9206675
77Absent/shortened dynein arms (HP:0200106)10.9206675
78Stage 5 chronic kidney disease (HP:0003774)1.98355769
79Partial agenesis of the corpus callosum (HP:0001338)1.97713451
80Abnormality of molar morphology (HP:0011070)1.94859931
81Abnormality of molar (HP:0011077)1.94859931
82Decreased motor nerve conduction velocity (HP:0003431)1.94679314
83Keratoconus (HP:0000563)1.94145614
84Increased corneal curvature (HP:0100692)1.94145614
85Abnormal drinking behavior (HP:0030082)1.92726941
86Polydipsia (HP:0001959)1.92726941
87Vaginal atresia (HP:0000148)1.92706244
88Progressive cerebellar ataxia (HP:0002073)1.91048676
89Cerebellar dysplasia (HP:0007033)1.90363963
90Abnormality of renin-angiotensin system (HP:0000847)1.89940786
91Abnormality of the dental pulp (HP:0006479)1.89928229
92Abnormal spermatogenesis (HP:0008669)1.89404133
93Absent speech (HP:0001344)1.88236161
94Clumsiness (HP:0002312)1.88111594
95Ankle clonus (HP:0011448)1.88086496
96Genital tract atresia (HP:0001827)1.88012197
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87237290
98Abnormality of dentin (HP:0010299)1.86038355
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82715036
100Abnormal gallbladder physiology (HP:0012438)1.81238207
101Cholecystitis (HP:0001082)1.81238207
102Aplasia/Hypoplasia of the macula (HP:0008059)1.78722940
103Spastic gait (HP:0002064)1.78622188
104Concave nail (HP:0001598)1.77296033
105Nephrogenic diabetes insipidus (HP:0009806)1.76514358
106IgG deficiency (HP:0004315)1.74574625
107Oculomotor apraxia (HP:0000657)1.72926637
108Asymmetry of the thorax (HP:0001555)1.72853036
109Type II lissencephaly (HP:0007260)1.72059563
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.71578093
111Cerebral hypomyelination (HP:0006808)1.71367116
112Retinitis pigmentosa (HP:0000510)1.70335079
113Supernumerary spleens (HP:0009799)1.69408793
114Postaxial hand polydactyly (HP:0001162)1.69397168
115Fused cervical vertebrae (HP:0002949)1.69186412
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68255745
117Stomach cancer (HP:0012126)1.67907928
118Aplasia/Hypoplasia of the lens (HP:0008063)1.66689320
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65961324
120Absent epiphyses (HP:0010577)1.65961324
121Asplenia (HP:0001746)1.65929127
122Intention tremor (HP:0002080)1.65928145
123Aplasia/Hypoplasia affecting the retina (HP:0008061)1.64677565
124Polyuria (HP:0000103)1.63891202
125Renal cortical cysts (HP:0000803)1.61779845
126Inability to walk (HP:0002540)1.61533541
127Termporal pattern (HP:0011008)1.61136710
128Insidious onset (HP:0003587)1.61136710
129Thyroid-stimulating hormone excess (HP:0002925)1.60961293
130Oligohydramnios (HP:0001562)1.60379997
131Progressive inability to walk (HP:0002505)1.58098886
132Parakeratosis (HP:0001036)1.57201336
133Elevated erythrocyte sedimentation rate (HP:0003565)1.57139340
134Macular degeneration (HP:0000608)1.55704927
135Hemiparesis (HP:0001269)1.54386628
136Hyperkalemia (HP:0002153)1.53760228
137Preaxial hand polydactyly (HP:0001177)1.53710312
138Poor coordination (HP:0002370)1.52919713
139Clonus (HP:0002169)1.52182992
140Impulsivity (HP:0100710)1.51970761
141Short femoral neck (HP:0100864)1.51766285
142Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.50609038
143True hermaphroditism (HP:0010459)1.49501728
144Segmental peripheral demyelination/remyelination (HP:0003481)1.49302404
145Tubulointerstitial fibrosis (HP:0005576)1.49266263
146Congenital hepatic fibrosis (HP:0002612)1.48930403
147Abnormality of saccadic eye movements (HP:0000570)1.48467582
148Abnormal auditory evoked potentials (HP:0006958)1.47892930
149Impaired proprioception (HP:0010831)1.47410097
150Leukodystrophy (HP:0002415)1.47358465
151Dysmetria (HP:0001310)1.46347588
152Difficulty walking (HP:0002355)1.45913256
153Abnormality of renal excretion (HP:0011036)1.44390590
154Myokymia (HP:0002411)1.42663514
155Pancreatic fibrosis (HP:0100732)1.42145814
156Short ribs (HP:0000773)1.41871698
157Choroideremia (HP:0001139)1.40258927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.31251867
2PDK46.31251867
3FRK5.90388183
4STK395.03039377
5PDK24.31076324
6TESK14.09937087
7PRKD33.93937426
8TAOK33.88754376
9ICK3.66504649
10TLK13.22438995
11WNK43.21948833
12ADRBK22.96368925
13TXK2.85075720
14ACVR1B2.80381817
15PNCK2.69546717
16PTK2B2.13664343
17INSRR2.11906936
18EPHB12.10566882
19ZAK1.99468893
20NUAK11.97207503
21OXSR11.94351240
22RIPK41.90591467
23MAPKAPK51.78945468
24BCR1.75888328
25WNK11.71806253
26MAP4K21.68372567
27EPHA31.64407375
28MAPK151.54162183
29MAPKAPK31.48845960
30MST41.46835088
31STK38L1.46471716
32TESK21.44802655
33NTRK21.40557133
34SIK21.33185231
35NTRK11.33044154
36TYRO31.32471787
37BMPR21.32091760
38TNIK1.26173161
39MAP2K21.25408192
40MET1.25352658
41DAPK21.21283752
42WNK31.19465073
43PKN11.19271654
44GRK61.16546822
45MAP3K71.12595899
46PBK1.06599235
47ADRBK11.03353813
48IKBKB1.03053796
49TNK20.98322566
50LATS10.96981269
51UHMK10.95305210
52FGFR20.95199493
53PRKAA20.93791023
54DYRK1B0.90468351
55HIPK20.84410768
56GRK50.82926772
57GRK70.82773367
58STK380.81853283
59PDK10.79374537
60PRKG20.77814991
61NEK20.76121638
62NEK60.75720127
63MARK10.74734053
64MELK0.74106452
65SGK2230.72996887
66SGK4940.72996887
67PAK60.70575967
68CAMKK20.69549566
69MARK30.68948236
70ITK0.68787793
71PLK40.68343915
72EPHA40.68027904
73PRKCE0.67475147
74CDK190.64730655
75IRAK10.63351319
76SYK0.62761270
77MARK20.61979595
78PHKG20.60486673
79PHKG10.60486673
80MAP3K130.60303948
81PRKAA10.58974695
82MUSK0.57765744
83CAMK2B0.57416820
84KIT0.56807823
85TIE10.56773439
86PDPK10.53290443
87MAP2K10.52839741
88DYRK20.51793057
89RPS6KA50.51673655
90PIK3CA0.49899977
91CDK180.49051005
92IKBKE0.48992475
93TEC0.48301703
94CDK140.48150915
95CLK10.47995566
96CHUK0.47194878
97PAK10.47147364
98BLK0.46205721
99KSR10.46138881
100CDK150.45269883
101CAMK2A0.44653626
102CAMK2D0.44396802
103MAP4K10.43858564
104PRKCI0.43555495
105ROCK20.42859009
106IGF1R0.42759281
107LIMK10.41357616
108CAMK1G0.41109329
109PRKCG0.40164124
110CAMK10.38649193
111PRKCQ0.38392878
112CDK11A0.37735522
113NLK0.37649739
114NTRK30.37421795
115PRKCA0.36935498
116PRKACA0.36920963
117CHEK20.36552063
118CDK50.36409412
119IRAK20.36298898
120LMTK20.35948388
121MAP3K40.34489709
122PINK10.34086977
123CAMK40.33797259
124CAMK2G0.33616955
125CHEK10.33370593
126FLT30.33020262
127CCNB10.32534039
128TBK10.32304254
129CSNK1G30.31863507
130BRSK20.31416672
131CSNK1G20.30999099
132CAMKK10.30935271
133MAPK130.29586785
134OBSCN0.29546485
135FGR0.29219729
136TRPM70.28810523
137NME10.28802300
138DYRK30.28681705
139SGK20.28462839
140MINK10.28428191
141PAK30.28010833
142TTK0.27461067
143GRK10.26421648
144CSNK1D0.25401508
145ERBB20.25271109
146BMPR1B0.24980665
147CASK0.23539108
148CSNK1A1L0.23500042
149PRKG10.22476166
150EIF2AK30.22316937
151MTOR0.22218517
152STK30.21930662
153CDC70.20731518
154PRKACB0.20500572
155PAK20.20007379
156STK110.18120523
157MAP2K70.17885655
158GSK3B0.17840784
159EPHB20.15768933
160DDR20.15635800
161PRKCZ0.15371703
162MAPK100.14366073
163PRKD10.13268136
164GSK3A0.13045867
165CSNK1G10.12452571

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.50925484
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.48788267
3Ether lipid metabolism_Homo sapiens_hsa005653.22360432
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09903466
5Linoleic acid metabolism_Homo sapiens_hsa005913.09064161
6Fatty acid biosynthesis_Homo sapiens_hsa000612.83875059
7Fatty acid elongation_Homo sapiens_hsa000622.81029355
8Steroid biosynthesis_Homo sapiens_hsa001002.80383232
9Pyruvate metabolism_Homo sapiens_hsa006202.66009002
10Phototransduction_Homo sapiens_hsa047442.41314009
11Chemical carcinogenesis_Homo sapiens_hsa052042.29609635
12Dorso-ventral axis formation_Homo sapiens_hsa043202.27461145
13Caffeine metabolism_Homo sapiens_hsa002322.26793804
14Propanoate metabolism_Homo sapiens_hsa006402.25139886
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24919648
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.24674067
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.16603109
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15922190
19ABC transporters_Homo sapiens_hsa020102.09948680
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01793411
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81053626
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.66552722
23Basal transcription factors_Homo sapiens_hsa030221.64275694
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64022237
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63261707
26Tryptophan metabolism_Homo sapiens_hsa003801.62178892
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61865186
28Retinol metabolism_Homo sapiens_hsa008301.59903246
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.52677593
30Amphetamine addiction_Homo sapiens_hsa050311.52152016
31beta-Alanine metabolism_Homo sapiens_hsa004101.51382512
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.48942238
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.42957501
34Axon guidance_Homo sapiens_hsa043601.39283440
35Glutamatergic synapse_Homo sapiens_hsa047241.34078951
36Primary immunodeficiency_Homo sapiens_hsa053401.34041882
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28895122
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28570030
39Nitrogen metabolism_Homo sapiens_hsa009101.27106205
40Huntingtons disease_Homo sapiens_hsa050161.25335559
41Fatty acid metabolism_Homo sapiens_hsa012121.23702490
42Oocyte meiosis_Homo sapiens_hsa041141.23541482
43Glucagon signaling pathway_Homo sapiens_hsa049221.23291908
44Glycerolipid metabolism_Homo sapiens_hsa005611.22708640
45Sphingolipid metabolism_Homo sapiens_hsa006001.22120669
46Mineral absorption_Homo sapiens_hsa049781.12750947
47Sulfur metabolism_Homo sapiens_hsa009201.10802603
48Hedgehog signaling pathway_Homo sapiens_hsa043401.10006550
49Cardiac muscle contraction_Homo sapiens_hsa042601.09673013
50Graft-versus-host disease_Homo sapiens_hsa053321.06333467
51Collecting duct acid secretion_Homo sapiens_hsa049661.06162573
52Arachidonic acid metabolism_Homo sapiens_hsa005901.04358859
53Renin secretion_Homo sapiens_hsa049241.04219919
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00629754
55Circadian rhythm_Homo sapiens_hsa047100.99125422
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98739029
57Circadian entrainment_Homo sapiens_hsa047130.97494465
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.96414873
59Long-term potentiation_Homo sapiens_hsa047200.96184018
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95865411
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95638924
62Histidine metabolism_Homo sapiens_hsa003400.94280988
63Synaptic vesicle cycle_Homo sapiens_hsa047210.93251033
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91562928
65Cocaine addiction_Homo sapiens_hsa050300.90613714
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89683142
67Glutathione metabolism_Homo sapiens_hsa004800.86946574
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86526230
69Phenylalanine metabolism_Homo sapiens_hsa003600.83684572
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83314979
71Tyrosine metabolism_Homo sapiens_hsa003500.82609181
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81901538
73Allograft rejection_Homo sapiens_hsa053300.81719129
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81669417
75Selenocompound metabolism_Homo sapiens_hsa004500.81308957
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80457164
77Peroxisome_Homo sapiens_hsa041460.79348740
78Fanconi anemia pathway_Homo sapiens_hsa034600.78647062
79Fatty acid degradation_Homo sapiens_hsa000710.78419193
80Endocytosis_Homo sapiens_hsa041440.77505546
81Ovarian steroidogenesis_Homo sapiens_hsa049130.77284260
82Pentose phosphate pathway_Homo sapiens_hsa000300.76893447
83Salivary secretion_Homo sapiens_hsa049700.76090166
84Gastric acid secretion_Homo sapiens_hsa049710.74337496
85PPAR signaling pathway_Homo sapiens_hsa033200.73404177
86Morphine addiction_Homo sapiens_hsa050320.72850763
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71332439
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70606614
89GABAergic synapse_Homo sapiens_hsa047270.69181812
90Cholinergic synapse_Homo sapiens_hsa047250.68945625
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68411091
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67499028
93African trypanosomiasis_Homo sapiens_hsa051430.67387737
94Tight junction_Homo sapiens_hsa045300.65171105
95Nicotine addiction_Homo sapiens_hsa050330.64550126
96Fat digestion and absorption_Homo sapiens_hsa049750.62945130
97Calcium signaling pathway_Homo sapiens_hsa040200.62083343
98Regulation of autophagy_Homo sapiens_hsa041400.60844550
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.60351258
100Oxytocin signaling pathway_Homo sapiens_hsa049210.60019038
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59682961
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.59307189
103Vibrio cholerae infection_Homo sapiens_hsa051100.58064953
104Type I diabetes mellitus_Homo sapiens_hsa049400.57628064
105Autoimmune thyroid disease_Homo sapiens_hsa053200.56866459
106Dopaminergic synapse_Homo sapiens_hsa047280.56693123
107Estrogen signaling pathway_Homo sapiens_hsa049150.55658677
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54959695
109Insulin secretion_Homo sapiens_hsa049110.54212284
110Olfactory transduction_Homo sapiens_hsa047400.54088000
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52646557
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52301581
113Oxidative phosphorylation_Homo sapiens_hsa001900.51914956
114Protein export_Homo sapiens_hsa030600.51598833
115Arginine and proline metabolism_Homo sapiens_hsa003300.51477559
116Alzheimers disease_Homo sapiens_hsa050100.51410062
117Basal cell carcinoma_Homo sapiens_hsa052170.50384864
118mRNA surveillance pathway_Homo sapiens_hsa030150.49998595
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49521770
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.49429767
121Purine metabolism_Homo sapiens_hsa002300.49192132
122Homologous recombination_Homo sapiens_hsa034400.48296744
123Alcoholism_Homo sapiens_hsa050340.47373002
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47091791
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46893429
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.46479219
127Metabolic pathways_Homo sapiens_hsa011000.46354578
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46097611
129Pancreatic secretion_Homo sapiens_hsa049720.45975775
130Taste transduction_Homo sapiens_hsa047420.45244636
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45146288
132Long-term depression_Homo sapiens_hsa047300.44812876
133Ras signaling pathway_Homo sapiens_hsa040140.43766433
134Antigen processing and presentation_Homo sapiens_hsa046120.43110712
135cAMP signaling pathway_Homo sapiens_hsa040240.42774698
136Wnt signaling pathway_Homo sapiens_hsa043100.42241994
137Inositol phosphate metabolism_Homo sapiens_hsa005620.41660406
138Serotonergic synapse_Homo sapiens_hsa047260.40480504
139Bile secretion_Homo sapiens_hsa049760.39109343
140Butanoate metabolism_Homo sapiens_hsa006500.38952211
141Asthma_Homo sapiens_hsa053100.38127043
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37913921
143VEGF signaling pathway_Homo sapiens_hsa043700.37616611
144Renal cell carcinoma_Homo sapiens_hsa052110.37333669
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.37254949
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37239041
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.36830070
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34808168
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32491887

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