CCDC130

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.06219510
2positive regulation of gamma-delta T cell activation (GO:0046645)5.04640526
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70041167
4negative regulation of cell killing (GO:0031342)4.70041167
5antigen processing and presentation of endogenous antigen (GO:0019883)4.49154380
6proteasome assembly (GO:0043248)4.41086601
7piRNA metabolic process (GO:0034587)4.36211742
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.27977159
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98879243
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93839906
11NIK/NF-kappaB signaling (GO:0038061)3.92622211
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90008053
13maturation of SSU-rRNA (GO:0030490)3.89015937
14regulation of B cell receptor signaling pathway (GO:0050855)3.88081822
15positive thymic T cell selection (GO:0045059)3.84981610
16binding of sperm to zona pellucida (GO:0007339)3.82835533
17response to muramyl dipeptide (GO:0032495)3.80817828
18negative regulation of interleukin-12 production (GO:0032695)3.72920876
19negative regulation of erythrocyte differentiation (GO:0045647)3.70430807
20protein localization to kinetochore (GO:0034501)3.64521534
21sperm-egg recognition (GO:0035036)3.62238190
22leukocyte aggregation (GO:0070486)3.61855474
23detection of bacterium (GO:0016045)3.58491396
24mitotic metaphase plate congression (GO:0007080)3.58407151
25multicellular organism reproduction (GO:0032504)3.57783281
26negative thymic T cell selection (GO:0045060)3.54806454
27regulation of gamma-delta T cell activation (GO:0046643)3.54740915
28tolerance induction (GO:0002507)3.52518792
29negative regulation of innate immune response (GO:0045824)3.52070588
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52050202
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.52043847
32termination of RNA polymerase III transcription (GO:0006386)3.52043847
33response to peptidoglycan (GO:0032494)3.51133213
34protein localization to chromosome, centromeric region (GO:0071459)3.49297669
35positive regulation of interleukin-17 production (GO:0032740)3.46013954
36detection of other organism (GO:0098543)3.45463684
37defense response to protozoan (GO:0042832)3.41731417
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40311958
39negative T cell selection (GO:0043383)3.40086756
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38598414
41regulation of alpha-beta T cell proliferation (GO:0046640)3.37428690
42mannose metabolic process (GO:0006013)3.36402969
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35214065
44positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.35074698
45Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34867477
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34196088
47ribosomal small subunit assembly (GO:0000028)3.31267297
48germinal center formation (GO:0002467)3.30015133
49metaphase plate congression (GO:0051310)3.27252343
50CENP-A containing nucleosome assembly (GO:0034080)3.26071426
51fusion of sperm to egg plasma membrane (GO:0007342)3.25531300
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25178688
53establishment of chromosome localization (GO:0051303)3.24705053
54cell-cell recognition (GO:0009988)3.22091446
55regulation of memory T cell differentiation (GO:0043380)3.21594311
56regulation of gamma-delta T cell differentiation (GO:0045586)3.21155050
57ribosome biogenesis (GO:0042254)3.20812783
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20808092
59thymic T cell selection (GO:0045061)3.20453480
60negative regulation of ligase activity (GO:0051352)3.16446374
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16446374
62DNA strand elongation involved in DNA replication (GO:0006271)3.15941410
63attachment of spindle microtubules to kinetochore (GO:0008608)3.15802103
64rRNA modification (GO:0000154)3.14731592
65regulation of spindle organization (GO:0090224)3.13322395
66positive regulation of T cell mediated cytotoxicity (GO:0001916)3.12649570
67telomere maintenance via semi-conservative replication (GO:0032201)3.12643476
68chromatin remodeling at centromere (GO:0031055)3.12397380
69regulation of T cell mediated cytotoxicity (GO:0001914)3.12066399
70positive regulation of granulocyte differentiation (GO:0030854)3.11273163
71purine nucleobase biosynthetic process (GO:0009113)3.11224290
72positive regulation of defense response to virus by host (GO:0002230)3.10557747
73DNA replication-independent nucleosome assembly (GO:0006336)3.10213780
74DNA replication-independent nucleosome organization (GO:0034724)3.10213780
75macrophage activation involved in immune response (GO:0002281)3.09026185
76cellular response to type I interferon (GO:0071357)3.08194807
77type I interferon signaling pathway (GO:0060337)3.08194807
78response to protozoan (GO:0001562)3.08188991
79response to interleukin-15 (GO:0070672)3.08142889
80response to type I interferon (GO:0034340)3.07535346
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07472362
82T cell migration (GO:0072678)3.07188800
83positive regulation of B cell differentiation (GO:0045579)3.07071566
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06747241
85negative regulation of sister chromatid segregation (GO:0033046)3.06747241
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.06747241
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06747241
88histone H2A acetylation (GO:0043968)3.06217416
89T cell selection (GO:0045058)3.05148631
90nucleobase biosynthetic process (GO:0046112)3.04434328
91mitotic spindle assembly checkpoint (GO:0007094)3.03396453
92positive T cell selection (GO:0043368)3.03053752
93negative regulation of chromosome segregation (GO:0051985)3.02595908
94male meiosis (GO:0007140)3.02333954
95modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01846661
96positive regulation by organism of defense response of other organism involved in symbiotic interact3.01846661
97modulation by symbiont of host immune response (GO:0052553)3.01846661
98positive regulation by symbiont of host defense response (GO:0052509)3.01846661
99modulation by symbiont of host defense response (GO:0052031)3.01846661
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01846661
101spindle checkpoint (GO:0031577)2.99733317
102maturation of 5.8S rRNA (GO:0000460)2.99389305
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99143020
104DNA methylation involved in gamete generation (GO:0043046)2.99081606
105positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98191298
106positive regulation of T-helper cell differentiation (GO:0045624)2.97961326
107formation of translation preinitiation complex (GO:0001731)2.97800375
108regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.97392312
109spindle assembly checkpoint (GO:0071173)2.96531280
110neutrophil activation involved in immune response (GO:0002283)2.95736522
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95415260
112DNA strand elongation (GO:0022616)2.95225259
113regulation of T cell tolerance induction (GO:0002664)2.94256013
114DNA replication initiation (GO:0006270)2.93416510
115ribonucleoprotein complex biogenesis (GO:0022613)2.92392268
116negative regulation of cytokine production involved in immune response (GO:0002719)2.92138217
1177-methylguanosine mRNA capping (GO:0006370)2.91968009
118phosphatidylglycerol biosynthetic process (GO:0006655)2.91864373
119exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90922760
120positive regulation of ligase activity (GO:0051351)2.90692152
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.90084306
122histone exchange (GO:0043486)2.89949359
123mitotic spindle checkpoint (GO:0071174)2.89550135
124negative regulation of leukocyte mediated immunity (GO:0002704)2.88842449
125regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87348364
126detection of external biotic stimulus (GO:0098581)2.86530779
127telomere maintenance via recombination (GO:0000722)2.86060553
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85865041
129regulation of activation of Janus kinase activity (GO:0010533)2.85782074
130transcription-coupled nucleotide-excision repair (GO:0006283)2.84300583
131RNA capping (GO:0036260)2.83463496
1327-methylguanosine RNA capping (GO:0009452)2.83463496
133ribosomal small subunit biogenesis (GO:0042274)2.83013136
134reproduction (GO:0000003)2.82971110
135mitotic nuclear envelope disassembly (GO:0007077)2.82222804
136cellular response to interleukin-15 (GO:0071350)2.82190337
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81606702
138negative regulation of interleukin-6 production (GO:0032715)2.80736204
139negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80660365
140interferon-gamma-mediated signaling pathway (GO:0060333)2.80411018
141protein localization to chromosome (GO:0034502)2.80358922
142positive regulation of alpha-beta T cell differentiation (GO:0046638)2.79696599
143regulation of antigen processing and presentation (GO:0002577)2.79509290
144positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79360124
145axonemal dynein complex assembly (GO:0070286)2.78697119
146rRNA methylation (GO:0031167)2.78611137
147male meiosis I (GO:0007141)2.77254203
148regulation of T-helper cell differentiation (GO:0045622)2.77047360
149regulation of ubiquitin-protein transferase activity (GO:0051438)2.76978332
150regulation of mast cell degranulation (GO:0043304)2.76952244
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76779890
152DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75852413
153opioid receptor signaling pathway (GO:0038003)2.75838309
154regulation of chromosome segregation (GO:0051983)2.75263973
155regulation of ligase activity (GO:0051340)2.73837812
156guanosine-containing compound biosynthetic process (GO:1901070)2.73701739
157activated T cell proliferation (GO:0050798)2.73255145
158regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73130715
159DNA-templated transcription, elongation (GO:0006354)2.73096602
160intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72196462
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72196462
162regulation of tolerance induction (GO:0002643)2.72136576
163regulation of defense response to virus by host (GO:0050691)2.72018802
164neutrophil activation (GO:0042119)2.71620180
165signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71240928
166signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71240928
167signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71240928
168protein deneddylation (GO:0000338)2.70955267
169neutrophil mediated immunity (GO:0002446)2.70628079
170synaptonemal complex organization (GO:0070193)2.70257445
171cellular extravasation (GO:0045123)2.69990174
172synaptonemal complex assembly (GO:0007130)2.69382684
173deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68985772
174meiosis I (GO:0007127)2.68316125
175single strand break repair (GO:0000012)2.68039759
176antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68026647
177transcription elongation from RNA polymerase I promoter (GO:0006362)2.67749076
178rRNA processing (GO:0006364)2.67360198
179B cell receptor signaling pathway (GO:0050853)2.67195426
180immunoglobulin mediated immune response (GO:0016064)2.66379128
181regulation of B cell differentiation (GO:0045577)2.65990186
182L-methionine salvage (GO:0071267)2.65500524
183L-methionine biosynthetic process (GO:0071265)2.65500524
184amino acid salvage (GO:0043102)2.65500524
185negative regulation of tumor necrosis factor production (GO:0032720)2.65080628
186positive regulation of antigen processing and presentation (GO:0002579)2.65008704
187rRNA metabolic process (GO:0016072)2.64968822
188protein K6-linked ubiquitination (GO:0085020)2.64306094
189regulation of alpha-beta T cell differentiation (GO:0046637)2.63804692
190regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63223096
191negative regulation of telomere maintenance (GO:0032205)2.63150972
192granulocyte activation (GO:0036230)2.63009045
193negative regulation of interleukin-10 production (GO:0032693)2.60286454
194regulation of interleukin-17 production (GO:0032660)2.59229160
195snRNA processing (GO:0016180)2.58513830
196negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.57744061
197positive regulation of interleukin-10 production (GO:0032733)2.56694023
198negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55976379
199actin nucleation (GO:0045010)2.55564092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.78381772
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52817992
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50837094
4E2F7_22180533_ChIP-Seq_HELA_Human3.44770799
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.37768113
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.34389327
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22006070
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.18533626
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.13251683
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05771401
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.05351054
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81004853
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.80273451
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79915675
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79518158
16VDR_23849224_ChIP-Seq_CD4+_Human2.69878770
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65323458
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63523152
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60039110
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49088290
21LXR_22292898_ChIP-Seq_THP-1_Human2.37295529
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35648958
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34301383
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33963128
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29605901
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28833259
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26457163
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22432355
29KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17196759
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14522573
31GABP_19822575_ChIP-Seq_HepG2_Human2.14048896
32FOXP3_21729870_ChIP-Seq_TREG_Human2.12538160
33XRN2_22483619_ChIP-Seq_HELA_Human2.11567019
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11516510
35VDR_24763502_ChIP-Seq_THP-1_Human2.11406797
36MAF_26560356_Chip-Seq_TH1_Human2.10775149
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.09321055
38UTX_26944678_Chip-Seq_JUKART_Human2.09050640
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08183170
40ELK3_25401928_ChIP-Seq_HUVEC_Human2.07989825
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04346687
42KDM2B_26808549_Chip-Seq_DND41_Human2.02967125
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99220275
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98686578
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.96632947
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96420620
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94446708
48BCL6_27268052_Chip-Seq_Bcells_Human1.91990097
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91338608
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90529758
51DCP1A_22483619_ChIP-Seq_HELA_Human1.89253417
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88185638
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.85962365
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82342312
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82322823
56TCF7_22412390_ChIP-Seq_EML_Mouse1.81245371
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78413737
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77696763
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75391891
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74533975
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71104794
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70752104
63* P68_20966046_ChIP-Seq_HELA_Human1.69756455
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66948172
65CIITA_25753668_ChIP-Seq_RAJI_Human1.65326063
66* BCOR_27268052_Chip-Seq_Bcells_Human1.64150790
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61399401
68TTF2_22483619_ChIP-Seq_HELA_Human1.60918441
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59565850
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58068862
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57854686
72SPI1_23127762_ChIP-Seq_K562_Human1.55555002
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.55417364
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55141469
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54928196
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53320111
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51349449
78ELK1_19687146_ChIP-ChIP_HELA_Human1.50467329
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.49525309
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48711843
81RUNX_20019798_ChIP-Seq_JUKART_Human1.48561152
82SCL_19346495_ChIP-Seq_HPC-7_Human1.48060480
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46905815
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44690522
85AR_21909140_ChIP-Seq_LNCAP_Human1.43709900
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41783755
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41129025
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40657288
89SPI1_23547873_ChIP-Seq_NB4_Human1.40609871
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40455383
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40142830
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.39768772
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38567864
94PHF8_20622854_ChIP-Seq_HELA_Human1.37429353
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36217171
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36171886
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36096443
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35639365
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35590260
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35501384
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35240069
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34926050
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33996592
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.33697245
105* SMC4_20622854_ChIP-Seq_HELA_Human1.33236454
106E2F1_20622854_ChIP-Seq_HELA_Human1.32112856
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31902985
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31618256
109MYC_22102868_ChIP-Seq_BL_Human1.31550498
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.30584242
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30395103
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28140965
113RARB_24833708_ChIP-Seq_LIVER_Mouse1.27027181
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26674005
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26575870
116KDM5A_27292631_Chip-Seq_BREAST_Human1.25343521
117IRF8_21731497_ChIP-ChIP_J774_Mouse1.24854701
118* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23710174
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23014311
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.22948298
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.21966260
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20262861
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19934068
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18824178
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18773547
126NCOR1_26117541_ChIP-Seq_K562_Human1.18697247
127FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18072024
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17804988
129* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13810903
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13331830
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12768169
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12581266
133CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12125217
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11352869
135RACK7_27058665_Chip-Seq_MCF-7_Human1.10816041
136STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10298838
137CTCF_26484167_Chip-Seq_Bcells_Mouse1.10040828
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09288595
139SA1_27219007_Chip-Seq_Bcells_Human1.07209019
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07120159
141E2F1_21310950_ChIP-Seq_MCF-7_Human1.06941361
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05661793
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05656833
144* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05497705
145CTCF_21964334_Chip-Seq_Bcells_Human1.05098846
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04618203
147FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04132787
148VDR_21846776_ChIP-Seq_THP-1_Human1.03236395
149MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03165708
150KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03137561
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99385869
152MYB_26560356_Chip-Seq_TH2_Human0.98433633
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98424899
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96508603
155TFEB_21752829_ChIP-Seq_HELA_Human0.94254987
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93888990
157MYC_18940864_ChIP-ChIP_HL60_Human0.92690894
158PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92145176
159MYB_26560356_Chip-Seq_TH1_Human0.91172222
160STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91006131
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.89525776
162TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88569169
163ELK1_22589737_ChIP-Seq_MCF10A_Human0.87096150
164* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85849767
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84516548
166PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84233399
167TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80815126
168MAF_26560356_Chip-Seq_TH2_Human0.80348646
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80197467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.33061715
2MP0003303_peritoneal_inflammation4.21672069
3MP0010094_abnormal_chromosome_stability4.00865723
4MP0005410_abnormal_fertilization3.75484633
5MP0003724_increased_susceptibility_to3.60994776
6MP0004957_abnormal_blastocyst_morpholog3.48572702
7MP0003111_abnormal_nucleus_morphology3.42240087
8MP0008877_abnormal_DNA_methylation3.30450859
9MP0008058_abnormal_DNA_repair3.27204390
10MP0003077_abnormal_cell_cycle3.07601949
11MP0008057_abnormal_DNA_replication2.80148970
12MP0003172_abnormal_lysosome_physiology2.76685639
13MP0002396_abnormal_hematopoietic_system2.72483945
14MP0005058_abnormal_lysosome_morphology2.71151009
15MP0008007_abnormal_cellular_replicative2.70723608
16MP0001929_abnormal_gametogenesis2.49381096
17MP0009278_abnormal_bone_marrow2.46831444
18MP0003763_abnormal_thymus_physiology2.44611054
19MP0003806_abnormal_nucleotide_metabolis2.43394466
20MP0006082_CNS_inflammation2.21494238
21MP0003300_gastrointestinal_ulcer2.16180646
22MP0008932_abnormal_embryonic_tissue2.14521455
23MP0003718_maternal_effect2.14142986
24MP0005671_abnormal_response_to2.07932151
25MP0001533_abnormal_skeleton_physiology1.98289341
26MP0002210_abnormal_sex_determination1.96534917
27MP0000685_abnormal_immune_system1.93732950
28MP0009333_abnormal_splenocyte_physiolog1.91391929
29MP0006292_abnormal_olfactory_placode1.91371217
30MP0003191_abnormal_cellular_cholesterol1.86607674
31MP0003698_abnormal_male_reproductive1.86114259
32MP0002398_abnormal_bone_marrow1.86026523
33MP0005397_hematopoietic_system_phenotyp1.80199025
34MP0001545_abnormal_hematopoietic_system1.80199025
35MP0003786_premature_aging1.78822985
36MP0001835_abnormal_antigen_presentation1.74359975
37MP0003646_muscle_fatigue1.70565893
38MP0009697_abnormal_copulation1.70459629
39MP0000653_abnormal_sex_gland1.61522568
40MP0002653_abnormal_ependyma_morphology1.61338959
41MP0001145_abnormal_male_reproductive1.60533104
42MP0009764_decreased_sensitivity_to1.59816443
43MP0005451_abnormal_body_composition1.56864120
44MP0000689_abnormal_spleen_morphology1.56671356
45MP0005075_abnormal_melanosome_morpholog1.54392817
46MP0006036_abnormal_mitochondrial_physio1.53179994
47MP0001730_embryonic_growth_arrest1.51852897
48MP0004147_increased_porphyrin_level1.49364052
49MP0002019_abnormal_tumor_incidence1.49291914
50MP0002722_abnormal_immune_system1.48666629
51MP0000703_abnormal_thymus_morphology1.45097140
52MP0002420_abnormal_adaptive_immunity1.43268675
53MP0000716_abnormal_immune_system1.42992460
54MP0000490_abnormal_crypts_of1.42738235
55MP0004510_myositis1.42346566
56MP0000465_gastrointestinal_hemorrhage1.40444906
57MP0003656_abnormal_erythrocyte_physiolo1.40364603
58MP0001819_abnormal_immune_cell1.40170209
59MP0008469_abnormal_protein_level1.40073264
60MP0004947_skin_inflammation1.39879032
61MP0002429_abnormal_blood_cell1.39498385
62MP0001800_abnormal_humoral_immune1.38903644
63MP0000604_amyloidosis1.38076459
64MP0002723_abnormal_immune_serum1.36902528
65MP0000015_abnormal_ear_pigmentation1.29768093
66MP0004808_abnormal_hematopoietic_stem1.28935181
67MP0000358_abnormal_cell_content/1.28804472
68MP0000350_abnormal_cell_proliferation1.28300959
69MP0002161_abnormal_fertility/fecundity1.27645541
70MP0002138_abnormal_hepatobiliary_system1.27587463
71MP0001119_abnormal_female_reproductive1.26171127
72MP0000313_abnormal_cell_death1.25062871
73MP0002452_abnormal_antigen_presenting1.24868290
74MP0001764_abnormal_homeostasis1.22613700
75MP0002132_abnormal_respiratory_system1.20568256
76MP0005000_abnormal_immune_tolerance1.20464091
77MP0000343_altered_response_to1.14969792
78MP0004381_abnormal_hair_follicle1.14180467
79MP0005025_abnormal_response_to1.10726579
80MP0002095_abnormal_skin_pigmentation1.08380576
81MP0009785_altered_susceptibility_to1.07817395
82MP0002405_respiratory_system_inflammati1.06339389
83MP0005360_urolithiasis1.05879643
84MP0002998_abnormal_bone_remodeling1.05817301
85MP0001986_abnormal_taste_sensitivity1.05518194
86MP0003075_altered_response_to1.04258874
87MP0005310_abnormal_salivary_gland1.02951445
88MP0002080_prenatal_lethality1.02091199
89MP0003329_amyloid_beta_deposits1.01142349
90MP0001697_abnormal_embryo_size1.01085718
91MP0003828_pulmonary_edema0.99587443
92MP0009763_increased_sensitivity_to0.97802616
93MP0001853_heart_inflammation0.96919119
94MP0006035_abnormal_mitochondrial_morpho0.96015506
95MP0001663_abnormal_digestive_system0.94073188
96MP0008260_abnormal_autophagy0.93394876
97MP0000858_altered_metastatic_potential0.92527515
98MP0009765_abnormal_xenobiotic_induced0.92486912
99MP0002332_abnormal_exercise_endurance0.91019461
100MP0005389_reproductive_system_phenotype0.90342906
101MP0002419_abnormal_innate_immunity0.89846561
102MP0005390_skeleton_phenotype0.89829256
103MP0001851_eye_inflammation0.88761638
104MP0010155_abnormal_intestine_physiology0.88759021
105MP0005408_hypopigmentation0.87406552
106MP0002102_abnormal_ear_morphology0.86941274
107MP0009840_abnormal_foam_cell0.85699477
108MP0005174_abnormal_tail_pigmentation0.85220636
109MP0002933_joint_inflammation0.85147956
110MP0003183_abnormal_peptide_metabolism0.84658220
111MP0008874_decreased_physiological_sensi0.84172421
112MP0003866_abnormal_defecation0.84072191
113MP0001790_abnormal_immune_system0.81834653
114MP0005387_immune_system_phenotype0.81834653
115MP0003186_abnormal_redox_activity0.81386784
116MP0003699_abnormal_female_reproductive0.79007803
117MP0003123_paternal_imprinting0.77621158
118MP0003436_decreased_susceptibility_to0.77486681
119MP0001873_stomach_inflammation0.77379050
120MP0003690_abnormal_glial_cell0.77288152
121MP0005167_abnormal_blood-brain_barrier0.77245113
122MP0005535_abnormal_body_temperature0.77001775
123MP0005464_abnormal_platelet_physiology0.76273422
124MP0005384_cellular_phenotype0.75683800
125MP0005166_decreased_susceptibility_to0.75334207
126MP0001672_abnormal_embryogenesis/_devel0.75274028
127MP0005380_embryogenesis_phenotype0.75274028
128MP0001502_abnormal_circadian_rhythm0.74902178
129MP0003221_abnormal_cardiomyocyte_apopto0.72191313
130MP0001529_abnormal_vocalization0.72186188
131MP0001905_abnormal_dopamine_level0.71727156
132MP0001845_abnormal_inflammatory_respons0.70971045
133MP0002148_abnormal_hypersensitivity_rea0.70964781
134MP0008995_early_reproductive_senescence0.70563638
135MP0003279_aneurysm0.70141033
136MP0002160_abnormal_reproductive_system0.67897864
137MP0005621_abnormal_cell_physiology0.67268790
138MP0005266_abnormal_metabolism0.66698877
139MP0003795_abnormal_bone_structure0.66589679
140MP0002277_abnormal_respiratory_mucosa0.65760746
141MP0001919_abnormal_reproductive_system0.64000474
142MP0000249_abnormal_blood_vessel0.63613616
143MP0005164_abnormal_response_to0.58719826
144MP0004883_abnormal_blood_vessel0.57645747
145MP0000751_myopathy0.52654319
146MP0005381_digestive/alimentary_phenotyp0.52187139
147MP0000609_abnormal_liver_physiology0.50754432
148MP0002166_altered_tumor_susceptibility0.50190067
149MP0001958_emphysema0.49269767
150MP0008875_abnormal_xenobiotic_pharmacok0.48463029
151MP0003448_altered_tumor_morphology0.48116072
152MP0003091_abnormal_cell_migration0.47776646
153MP0001501_abnormal_sleep_pattern0.46559739

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.83563251
2Myositis (HP:0100614)4.57855944
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.23769229
4Aplastic anemia (HP:0001915)4.13111745
5Abnormality of macrophages (HP:0004311)3.98979211
6Stomatitis (HP:0010280)3.98412268
7Mediastinal lymphadenopathy (HP:0100721)3.88148854
8Orchitis (HP:0100796)3.85161856
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.84570790
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.82498869
11Recurrent bacterial skin infections (HP:0005406)3.73525080
12Recurrent fungal infections (HP:0002841)3.71850335
13Recurrent cutaneous fungal infections (HP:0011370)3.53515345
14Chronic mucocutaneous candidiasis (HP:0002728)3.53515345
15Abnormal number of erythroid precursors (HP:0012131)3.50868492
16Retrobulbar optic neuritis (HP:0100654)3.49774324
17Optic neuritis (HP:0100653)3.49774324
18Chronic bronchitis (HP:0004469)3.43884678
19Colitis (HP:0002583)3.41458504
20Abnormality of cells of the erythroid lineage (HP:0012130)3.34772143
21Dysostosis multiplex (HP:0000943)3.32094967
22Cerebral hypomyelination (HP:0006808)3.30552433
23Meningitis (HP:0001287)3.20504317
24Nasal polyposis (HP:0100582)3.18624318
25Agammaglobulinemia (HP:0004432)3.10097692
26Pustule (HP:0200039)3.07362191
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.06948221
28Absent/shortened dynein arms (HP:0200106)3.06948221
29Increased IgE level (HP:0003212)3.00623269
30Encephalitis (HP:0002383)2.99762955
31Reticulocytopenia (HP:0001896)2.98751647
32Inflammation of the large intestine (HP:0002037)2.97942419
33Abnormality of polysaccharide metabolism (HP:0011012)2.96369166
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96369166
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96369166
36Gastrointestinal inflammation (HP:0004386)2.95575135
37Birth length less than 3rd percentile (HP:0003561)2.95411057
38Abnormality of glycolipid metabolism (HP:0010969)2.94265683
39Abnormality of liposaccharide metabolism (HP:0010968)2.94265683
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.94265683
41Obstructive lung disease (HP:0006536)2.94163318
42Chronic obstructive pulmonary disease (HP:0006510)2.94163318
43Carpal bone hypoplasia (HP:0001498)2.93940928
44Abnormal respiratory motile cilium physiology (HP:0012261)2.92378049
45Loss of speech (HP:0002371)2.90768590
46Systemic lupus erythematosus (HP:0002725)2.89263521
47Premature ovarian failure (HP:0008209)2.88784600
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88731993
49Rhinitis (HP:0012384)2.88056738
50Bone marrow hypocellularity (HP:0005528)2.84275663
51Pancytopenia (HP:0001876)2.81766834
52Recurrent skin infections (HP:0001581)2.81369047
53Recurrent viral infections (HP:0004429)2.77423838
54Breast hypoplasia (HP:0003187)2.76456684
55Recurrent gram-negative bacterial infections (HP:0005420)2.75835757
563-Methylglutaconic aciduria (HP:0003535)2.75504253
57Bronchitis (HP:0012387)2.75316546
58Abnormality of the preputium (HP:0100587)2.72015419
59Myelodysplasia (HP:0002863)2.71372559
60Gastrointestinal infarctions (HP:0005244)2.70697712
61Rough bone trabeculation (HP:0100670)2.69010995
62IgM deficiency (HP:0002850)2.67977553
63Mucopolysacchariduria (HP:0008155)2.66455357
64Urinary glycosaminoglycan excretion (HP:0003541)2.66455357
65Vasculitis (HP:0002633)2.63189725
66Oral leukoplakia (HP:0002745)2.61582065
67Increased IgM level (HP:0003496)2.61426558
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60505837
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60505837
70Abnormality of the nasal mucosa (HP:0000433)2.60391325
71Type 2 muscle fiber atrophy (HP:0003554)2.60384625
72Increased cerebral lipofuscin (HP:0011813)2.60152753
73Pallor (HP:0000980)2.57136794
74Granulocytopenia (HP:0001913)2.56146877
75Abnormal spermatogenesis (HP:0008669)2.55886362
76Abnormal respiratory motile cilium morphology (HP:0005938)2.53637724
77Abnormal respiratory epithelium morphology (HP:0012253)2.53637724
78IgG deficiency (HP:0004315)2.51719017
79Cellulitis (HP:0100658)2.50870921
80Pulmonary infiltrates (HP:0002113)2.49081347
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47479545
82Muscle fiber atrophy (HP:0100295)2.47104356
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46003790
84Chest pain (HP:0100749)2.43063492
85Thrombocytosis (HP:0001894)2.41498965
86Sloping forehead (HP:0000340)2.41494832
87Patellar aplasia (HP:0006443)2.40501136
88Gingivitis (HP:0000230)2.40396407
89Meckel diverticulum (HP:0002245)2.39942988
90Type I transferrin isoform profile (HP:0003642)2.37756802
91Hemoptysis (HP:0002105)2.36056546
92Elevated erythrocyte sedimentation rate (HP:0003565)2.35601834
93Combined immunodeficiency (HP:0005387)2.35288472
94Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34576014
95Lymphopenia (HP:0001888)2.34492199
96Amyloidosis (HP:0011034)2.33333599
97Increased serum ferritin (HP:0003281)2.32912743
98Abnormality of T cells (HP:0002843)2.31636082
99Vacuolated lymphocytes (HP:0001922)2.31255480
100Recurrent abscess formation (HP:0002722)2.30512865
101Keratoconjunctivitis sicca (HP:0001097)2.30054242
102CNS hypomyelination (HP:0003429)2.29988139
103Recurrent bronchitis (HP:0002837)2.29604458
104Abnormality of the ileum (HP:0001549)2.28978099
105J-shaped sella turcica (HP:0002680)2.28949126
106Facial hemangioma (HP:0000329)2.28663563
107Urticaria (HP:0001025)2.28562487
108Infertility (HP:0000789)2.28157223
109Abnormal protein glycosylation (HP:0012346)2.25979323
110Abnormal glycosylation (HP:0012345)2.25979323
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25979323
112Abnormal protein N-linked glycosylation (HP:0012347)2.25979323
113Abnormality of chromosome stability (HP:0003220)2.25710090
114Aplasia/Hypoplasia of the uvula (HP:0010293)2.24950463
115Increased neuronal autofluorescent lipopigment (HP:0002074)2.24510003
116Hypergammaglobulinemia (HP:0010702)2.24428801
117Microretrognathia (HP:0000308)2.23219651
118Aplasia/Hypoplasia of the patella (HP:0006498)2.22829157
119Bronchiectasis (HP:0002110)2.22798141
120Episodic fever (HP:0001954)2.22329773
121Thoracic kyphosis (HP:0002942)2.20400438
122Colon cancer (HP:0003003)2.18782043
123Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17112080
124Keratoconjunctivitis (HP:0001096)2.16457391
125Abnormality of alanine metabolism (HP:0010916)2.16318518
126Hyperalaninemia (HP:0003348)2.16318518
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16318518
128Degeneration of anterior horn cells (HP:0002398)2.15122809
129Abnormality of the anterior horn cell (HP:0006802)2.15122809
130Leukocytosis (HP:0001974)2.13250965
131Secondary amenorrhea (HP:0000869)2.11783813
132Entropion (HP:0000621)2.09684471
133Keratitis (HP:0000491)2.08988089
134Duodenal stenosis (HP:0100867)2.08327997
135Small intestinal stenosis (HP:0012848)2.08327997
136Selective tooth agenesis (HP:0001592)2.06248901
137Severe combined immunodeficiency (HP:0004430)2.05986738
138Macrocytic anemia (HP:0001972)2.05502531
139Gastrointestinal stroma tumor (HP:0100723)2.05178557
140Joint stiffness (HP:0001387)2.04905849
141Neurodegeneration (HP:0002180)2.04566779
142Abnormality of cells of the lymphoid lineage (HP:0012140)2.04346630
143T lymphocytopenia (HP:0005403)2.03915555
144Abnormality of the pleura (HP:0002103)2.02066475
145Absent thumb (HP:0009777)2.01347440
146Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00041362
147Abnormal ciliary motility (HP:0012262)1.99789630
148Spontaneous hematomas (HP:0007420)1.99703096
149Emphysema (HP:0002097)1.98840196
150Hepatocellular necrosis (HP:0001404)1.98106071
151Hepatosplenomegaly (HP:0001433)1.97720253
152Asymmetric septal hypertrophy (HP:0001670)1.97699481
153Adrenal hypoplasia (HP:0000835)1.97430897
154Increased serum lactate (HP:0002151)1.97139182
155Tongue fasciculations (HP:0001308)1.93821095
156Petechiae (HP:0000967)1.93195147
157Abnormality of iron homeostasis (HP:0011031)1.92719167
15811 pairs of ribs (HP:0000878)1.91063356
159Lymphoma (HP:0002665)1.90241675
160Autoimmune thrombocytopenia (HP:0001973)1.89785706
161Acute hepatic failure (HP:0006554)1.89779046
162Abnormality of T cell physiology (HP:0011840)1.89727613
163Recurrent sinusitis (HP:0011108)1.89035372
164Panhypogammaglobulinemia (HP:0003139)1.88206940
165Interstitial pulmonary disease (HP:0006530)1.87249302
166Abnormality of T cell number (HP:0011839)1.87144881
167Verrucae (HP:0200043)1.87104169
168Papilloma (HP:0012740)1.87104169
169Lipid accumulation in hepatocytes (HP:0006561)1.87024059
170Ragged-red muscle fibers (HP:0003200)1.86969866
171Neuronal loss in central nervous system (HP:0002529)1.86817731
172Poor head control (HP:0002421)1.86387634
173Exertional dyspnea (HP:0002875)1.85887948
174Squamous cell carcinoma (HP:0002860)1.85540273
175Prolonged bleeding time (HP:0003010)1.85540171
176Postnatal microcephaly (HP:0005484)1.85453159
177Hemorrhage of the eye (HP:0011885)1.85353031
178Cholecystitis (HP:0001082)1.84611585
179Abnormal gallbladder physiology (HP:0012438)1.84611585
180Hypochromic anemia (HP:0001931)1.84605843
181Increased CSF lactate (HP:0002490)1.84596764
182Supranuclear gaze palsy (HP:0000605)1.84536660
183Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84214840
184Thin bony cortex (HP:0002753)1.83661324
185Sepsis (HP:0100806)1.83011815
186Chronic otitis media (HP:0000389)1.82646480
187Mitochondrial inheritance (HP:0001427)1.81550627
188Abnormal trabecular bone morphology (HP:0100671)1.81129727
189Eosinophilia (HP:0001880)1.80639579
190Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80627941
191Cerebral palsy (HP:0100021)1.80399247
192Impulsivity (HP:0100710)1.80295412
193Recurrent otitis media (HP:0000403)1.80122211
194Abnormality of DNA repair (HP:0003254)1.78005079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.35339538
2BUB14.24032570
3WEE13.89726012
4STK163.56286699
5EIF2AK13.38368902
6TESK22.88934625
7BRSK22.56805742
8PLK42.39167411
9TNK22.33721536
10TTK2.27638519
11PRPF4B2.26130631
12NEK22.25341096
13ACVR1B2.24645707
14MAP2K32.18499710
15PIM22.18487101
16FES2.14879207
17RIPK42.14183196
18PDK32.07799877
19PDK42.07799877
20MAP4K12.06810328
21STK101.99014398
22DYRK31.89029531
23VRK11.86607841
24SIK21.84136907
25ARAF1.81661221
26EIF2AK31.74565743
27TESK11.74339535
28JAK31.69167205
29PLK11.68867915
30BRAF1.62861152
31CSK1.58708408
32GRK61.56824573
33ICK1.55006733
34PDK21.48048038
35MAP3K141.47826553
36EPHB11.42570388
37CDC71.38485540
38ZAP701.37160424
39RPS6KA41.30622494
40BRSK11.29217467
41TLK11.25009538
42MARK21.24673149
43BTK1.23901521
44CCNB11.23737809
45HCK1.22614276
46EEF2K1.21789380
47MAPKAPK51.21705455
48SRPK11.21611234
49TRIB31.21440941
50IKBKB1.20836791
51TSSK61.19075558
52KIT1.18634408
53NME21.17960402
54MAP3K111.17778590
55PRKD31.14944993
56MAP3K131.13962997
57BLK1.13456160
58MAP4K21.12048659
59SIK11.11687276
60BCKDK1.07463044
61AURKA1.07317937
62AURKB1.06460046
63PRKD21.04546799
64FLT31.02347548
65CDK71.00984941
66TAOK11.00854766
67SMG11.00153087
68PIM10.98106919
69MAP3K80.95486984
70CSNK1G30.94154020
71ATR0.92249381
72MAPKAPK30.91639716
73DYRK20.90592105
74EPHA30.90022448
75CHEK20.89619758
76MAPK120.89031448
77MAP3K70.87856637
78PASK0.86977012
79PLK30.86744748
80JAK10.86429550
81TYK20.84988770
82JAK20.84842033
83SCYL20.83963625
84IRAK30.80585483
85NME10.80296358
86HIPK20.79841010
87KDR0.79352263
88CSF1R0.78711818
89TBK10.78022993
90MAP2K40.76983233
91MAP3K10.75824182
92MAP2K60.75099732
93SIK30.75095430
94MUSK0.74739582
95CDC42BPA0.74531345
96DYRK1B0.74268184
97PRKCI0.73510470
98NUAK10.73225958
99GRK70.71215290
100PTK60.69120254
101IRAK40.68468884
102RPS6KA50.68391673
103TYRO30.67912501
104TXK0.66943697
105MAP3K120.66722195
106NLK0.65506390
107FGR0.64659911
108MATK0.63069231
109CSNK1A1L0.62315761
110PDK10.62063618
111CHEK10.61556705
112MAPK150.61387896
113TGFBR20.61345100
114CDK30.59218480
115MAPK110.58613693
116MAPK70.56475598
117IKBKE0.56004341
118CHUK0.53780257
119MARK30.53666692
120SYK0.53246461
121CSNK2A10.52795301
122CDK90.52005826
123PRKCQ0.51230309
124CDK40.51216347
125CSNK1G10.51081954
126LCK0.50463305
127RPS6KB20.49863058
128LRRK20.49787445
129TEC0.49168775
130TAOK30.49009463
131CAMKK10.48439454
132PDPK10.46956496
133MAP3K30.46605405
134DYRK1A0.46547926
135LYN0.46387516
136TAOK20.45640811
137RPS6KL10.45553860
138RPS6KC10.45553860
139FGFR40.44962837
140STK40.44194621
141ITK0.42349281
142RPS6KA20.41381101
143PINK10.40916216
144PTK2B0.40477727
145PRKD10.40378404
146MAPK40.39977646
147CLK10.39032612
148MAP2K20.38986185
149FYN0.38954554
150PAK10.38866718
151MAP2K70.38170544
152PRKCZ0.37937583
153PKN10.37727796
154STK110.37349419
155CAMKK20.37152273
156CSNK2A20.36907933
157CDK190.36030471
158MAP3K50.35922295
159MAPK130.35633274
160MOS0.34779218
161ATM0.34477927
162CDK20.34447256
163MAP3K60.31879414
164MAPKAPK20.28253276
165IRAK10.28145629

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.90443263
2DNA replication_Homo sapiens_hsa030303.55627508
3Proteasome_Homo sapiens_hsa030503.51565864
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22028974
5Homologous recombination_Homo sapiens_hsa034403.05932109
6Ribosome_Homo sapiens_hsa030102.98043968
7Mismatch repair_Homo sapiens_hsa034302.92930447
8Spliceosome_Homo sapiens_hsa030402.75388784
9Autoimmune thyroid disease_Homo sapiens_hsa053202.67019869
10Basal transcription factors_Homo sapiens_hsa030222.65258579
11Pyrimidine metabolism_Homo sapiens_hsa002402.63325391
12Non-homologous end-joining_Homo sapiens_hsa034502.62868835
13RNA transport_Homo sapiens_hsa030132.57024878
14Base excision repair_Homo sapiens_hsa034102.55127587
15Leishmaniasis_Homo sapiens_hsa051402.53161896
16Staphylococcus aureus infection_Homo sapiens_hsa051502.47999982
17Nucleotide excision repair_Homo sapiens_hsa034202.42764128
18Osteoclast differentiation_Homo sapiens_hsa043802.39040156
19Fanconi anemia pathway_Homo sapiens_hsa034602.38642057
20Protein export_Homo sapiens_hsa030602.38107724
21Cell cycle_Homo sapiens_hsa041102.28414850
22RNA degradation_Homo sapiens_hsa030182.24991154
23Glycosaminoglycan degradation_Homo sapiens_hsa005312.20058743
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19452053
25Tuberculosis_Homo sapiens_hsa051522.01005216
26Type I diabetes mellitus_Homo sapiens_hsa049402.00305912
27Vitamin B6 metabolism_Homo sapiens_hsa007501.84077415
28Primary immunodeficiency_Homo sapiens_hsa053401.77924545
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77249798
30Rheumatoid arthritis_Homo sapiens_hsa053231.77241265
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70399063
32Viral myocarditis_Homo sapiens_hsa054161.68319383
33Purine metabolism_Homo sapiens_hsa002301.65138851
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65090165
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64099599
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60983050
37Pertussis_Homo sapiens_hsa051331.55195294
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52728088
39Lysosome_Homo sapiens_hsa041421.50477050
40Antigen processing and presentation_Homo sapiens_hsa046121.48265419
41Toxoplasmosis_Homo sapiens_hsa051451.45157826
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40376072
43p53 signaling pathway_Homo sapiens_hsa041151.39732348
44Malaria_Homo sapiens_hsa051441.36947262
45Pentose phosphate pathway_Homo sapiens_hsa000301.34527235
46mRNA surveillance pathway_Homo sapiens_hsa030151.34154109
47TNF signaling pathway_Homo sapiens_hsa046681.33237086
48Epstein-Barr virus infection_Homo sapiens_hsa051691.31848504
49Phagosome_Homo sapiens_hsa041451.26322924
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24341234
51Regulation of autophagy_Homo sapiens_hsa041401.22511150
52Salmonella infection_Homo sapiens_hsa051321.21615868
53Folate biosynthesis_Homo sapiens_hsa007901.09473010
54Other glycan degradation_Homo sapiens_hsa005111.08829177
55Chemokine signaling pathway_Homo sapiens_hsa040621.08595443
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03975517
57Oocyte meiosis_Homo sapiens_hsa041140.98138455
58Hepatitis C_Homo sapiens_hsa051600.96763496
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94452475
60Hematopoietic cell lineage_Homo sapiens_hsa046400.94034941
61Huntingtons disease_Homo sapiens_hsa050160.92749163
62Notch signaling pathway_Homo sapiens_hsa043300.91291597
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90130984
64Herpes simplex infection_Homo sapiens_hsa051680.89261031
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88590744
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.88538391
67VEGF signaling pathway_Homo sapiens_hsa043700.87270043
68Endocytosis_Homo sapiens_hsa041440.86786180
69Linoleic acid metabolism_Homo sapiens_hsa005910.84579864
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81939232
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80330286
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78398251
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.77801081
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75909579
75Oxidative phosphorylation_Homo sapiens_hsa001900.75400648
76Parkinsons disease_Homo sapiens_hsa050120.74957456
77Ether lipid metabolism_Homo sapiens_hsa005650.74573787
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73047886
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.72457765
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71164649
81African trypanosomiasis_Homo sapiens_hsa051430.70803977
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70737335
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70568608
84Selenocompound metabolism_Homo sapiens_hsa004500.70270791
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70102308
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69976119
87Viral carcinogenesis_Homo sapiens_hsa052030.69701302
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.68884854
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.67825331
90One carbon pool by folate_Homo sapiens_hsa006700.67767573
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.67132769
92Measles_Homo sapiens_hsa051620.66181630
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.63566654
94Chronic myeloid leukemia_Homo sapiens_hsa052200.62676195
95Prion diseases_Homo sapiens_hsa050200.61350644
96Sphingolipid metabolism_Homo sapiens_hsa006000.59933320
97Non-small cell lung cancer_Homo sapiens_hsa052230.56858439
98Legionellosis_Homo sapiens_hsa051340.54751805
99B cell receptor signaling pathway_Homo sapiens_hsa046620.54343754
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52055560
101Synaptic vesicle cycle_Homo sapiens_hsa047210.51779088
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.50640396
103Systemic lupus erythematosus_Homo sapiens_hsa053220.50194628
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.49511097
105mTOR signaling pathway_Homo sapiens_hsa041500.49508043
106HTLV-I infection_Homo sapiens_hsa051660.49364281
107Pancreatic cancer_Homo sapiens_hsa052120.47596361
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.46416726
109Platelet activation_Homo sapiens_hsa046110.45870382
110Biosynthesis of amino acids_Homo sapiens_hsa012300.44538655
111Metabolic pathways_Homo sapiens_hsa011000.42603985
112Fructose and mannose metabolism_Homo sapiens_hsa000510.42501808
113N-Glycan biosynthesis_Homo sapiens_hsa005100.42024121
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41792903
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40678049
116Acute myeloid leukemia_Homo sapiens_hsa052210.39677664
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39363225
118Pyruvate metabolism_Homo sapiens_hsa006200.39193010
119Choline metabolism in cancer_Homo sapiens_hsa052310.38413588
120Shigellosis_Homo sapiens_hsa051310.38405643
121T cell receptor signaling pathway_Homo sapiens_hsa046600.38268467
122Asthma_Homo sapiens_hsa053100.38181061
123Bladder cancer_Homo sapiens_hsa052190.38012631
124Insulin resistance_Homo sapiens_hsa049310.37765756
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.36828850
126Arachidonic acid metabolism_Homo sapiens_hsa005900.36289617
127Apoptosis_Homo sapiens_hsa042100.36137119
128GnRH signaling pathway_Homo sapiens_hsa049120.35295629
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35127701
130Allograft rejection_Homo sapiens_hsa053300.34928730
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.34923173
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33963751
133Vibrio cholerae infection_Homo sapiens_hsa051100.33250750
134Prolactin signaling pathway_Homo sapiens_hsa049170.33006027
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32779342
136MAPK signaling pathway_Homo sapiens_hsa040100.32384481
137Alcoholism_Homo sapiens_hsa050340.32158501
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31977804
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31723488
140Carbon metabolism_Homo sapiens_hsa012000.31647221
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31588075
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31497264
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31338886
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30977567
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30374715
146FoxO signaling pathway_Homo sapiens_hsa040680.30096943
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29606649
148Sulfur relay system_Homo sapiens_hsa041220.29210780
149Graft-versus-host disease_Homo sapiens_hsa053320.28789926
150Collecting duct acid secretion_Homo sapiens_hsa049660.28382020
151Hepatitis B_Homo sapiens_hsa051610.28192207
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26316220
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25741637
154Alzheimers disease_Homo sapiens_hsa050100.25576069
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24287062
156Colorectal cancer_Homo sapiens_hsa052100.23461556
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21725442
158Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21443492
159Glutathione metabolism_Homo sapiens_hsa004800.19013863
160Influenza A_Homo sapiens_hsa051640.18635261
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18565708
162Maturity onset diabetes of the young_Homo sapiens_hsa049500.17861024

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