CCDC134

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.41935538
2cellular protein complex localization (GO:0034629)4.26719502
3positive regulation of gamma-delta T cell activation (GO:0046645)4.21702381
4ribosomal small subunit assembly (GO:0000028)4.16467719
5DNA strand elongation involved in DNA replication (GO:0006271)4.14960886
6protein complex localization (GO:0031503)4.04777597
7pore complex assembly (GO:0046931)3.97001680
8single strand break repair (GO:0000012)3.93053740
9DNA strand elongation (GO:0022616)3.91560091
10antigen processing and presentation of endogenous antigen (GO:0019883)3.91167618
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88793840
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88793840
13chromosome condensation (GO:0030261)3.82262952
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78141226
15DNA deamination (GO:0045006)3.70308106
16telomere maintenance via semi-conservative replication (GO:0032201)3.69841085
17DNA replication initiation (GO:0006270)3.65678244
18DNA unwinding involved in DNA replication (GO:0006268)3.57708938
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56833083
20sister chromatid segregation (GO:0000819)3.55373486
21DNA packaging (GO:0006323)3.54796807
22mitotic metaphase plate congression (GO:0007080)3.46367817
23viral transcription (GO:0019083)3.42758519
24maturation of SSU-rRNA (GO:0030490)3.40529041
25regulation of translation in response to stress (GO:0043555)3.39593738
26telomere maintenance via recombination (GO:0000722)3.38242353
27translational termination (GO:0006415)3.35442140
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34587312
29tRNA methylation (GO:0030488)3.34014187
30signal peptide processing (GO:0006465)3.27247004
31protein localization to kinetochore (GO:0034501)3.18576225
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17702433
33chromatin assembly (GO:0031497)3.17216757
34mitotic recombination (GO:0006312)3.16032631
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.15334393
36cotranslational protein targeting to membrane (GO:0006613)3.14565710
37formation of translation preinitiation complex (GO:0001731)3.13145794
38mitochondrial fusion (GO:0008053)3.12580877
39protein targeting to ER (GO:0045047)3.11474047
403-UTR-mediated mRNA stabilization (GO:0070935)3.11282762
41ncRNA 3-end processing (GO:0043628)3.10725123
42B cell receptor signaling pathway (GO:0050853)3.10619736
43protein localization to chromosome, centromeric region (GO:0071459)3.10282729
44DNA conformation change (GO:0071103)3.10046532
45DNA duplex unwinding (GO:0032508)3.09808178
46rRNA transcription (GO:0009303)3.09317642
47ribosomal small subunit biogenesis (GO:0042274)3.07889450
48peptidyl-arginine omega-N-methylation (GO:0035247)3.05526422
49translational elongation (GO:0006414)3.02775351
50regulation of translational fidelity (GO:0006450)3.02078362
51regulation of gamma-delta T cell differentiation (GO:0045586)2.99293907
52positive regulation of B cell differentiation (GO:0045579)2.98637897
53heterochromatin organization (GO:0070828)2.96651122
54regulation of gamma-delta T cell activation (GO:0046643)2.96199211
55establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96186705
56positive thymic T cell selection (GO:0045059)2.95892101
57protein localization to endoplasmic reticulum (GO:0070972)2.95782224
58DNA geometric change (GO:0032392)2.93682672
59T cell homeostasis (GO:0043029)2.92498384
60regulation of mammary gland epithelial cell proliferation (GO:0033599)2.90987894
61establishment of integrated proviral latency (GO:0075713)2.90031064
62mitotic nuclear envelope disassembly (GO:0007077)2.89707285
63nucleotide-excision repair, DNA gap filling (GO:0006297)2.89060680
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88174793
65non-recombinational repair (GO:0000726)2.87523561
66double-strand break repair via nonhomologous end joining (GO:0006303)2.87523561
67translational initiation (GO:0006413)2.87034585
68pyrimidine nucleoside salvage (GO:0043097)2.85474275
69pyrimidine-containing compound salvage (GO:0008655)2.85474275
70nuclear envelope organization (GO:0006998)2.84522614
71DNA replication checkpoint (GO:0000076)2.83966151
72Golgi transport vesicle coating (GO:0048200)2.83384509
73COPI coating of Golgi vesicle (GO:0048205)2.83384509
74leukocyte aggregation (GO:0070486)2.82418513
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80892696
76mitochondrial DNA metabolic process (GO:0032042)2.77971787
77positive regulation of cell size (GO:0045793)2.77421899
78ribosome assembly (GO:0042255)2.76815154
79nucleobase-containing small molecule interconversion (GO:0015949)2.76472438
80metaphase plate congression (GO:0051310)2.74696167
81embryonic process involved in female pregnancy (GO:0060136)2.74439561
82pyrimidine dimer repair (GO:0006290)2.74192773
83pentose metabolic process (GO:0019321)2.72802510
84ribosome biogenesis (GO:0042254)2.71886031
85RNA stabilization (GO:0043489)2.70196885
86mRNA stabilization (GO:0048255)2.70196885
87cellular protein complex disassembly (GO:0043624)2.69882874
88pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69033485
89mast cell activation (GO:0045576)2.68394985
90rRNA methylation (GO:0031167)2.67976413
91IMP biosynthetic process (GO:0006188)2.67045997
92chromatin assembly or disassembly (GO:0006333)2.63540151
93histone arginine methylation (GO:0034969)2.62231978
94viral life cycle (GO:0019058)2.62008976
95CENP-A containing nucleosome assembly (GO:0034080)2.61559871
96DNA replication-independent nucleosome organization (GO:0034724)2.61488784
97DNA replication-independent nucleosome assembly (GO:0006336)2.61488784
98nuclear envelope disassembly (GO:0051081)2.61338790
99membrane disassembly (GO:0030397)2.61338790
100regulation of B cell differentiation (GO:0045577)2.60913197
101establishment of chromosome localization (GO:0051303)2.59876508
102nucleobase biosynthetic process (GO:0046112)2.59084872
103regulation of chromosome segregation (GO:0051983)2.58871721
104positive regulation of DNA-dependent DNA replication (GO:2000105)2.57714789
105IMP metabolic process (GO:0046040)2.57450137
106chromatin silencing (GO:0006342)2.57385969
107DNA replication-dependent nucleosome organization (GO:0034723)2.56410286
108DNA replication-dependent nucleosome assembly (GO:0006335)2.56410286
109regulation of mitochondrial translation (GO:0070129)2.55293627
110somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53560907
111somatic hypermutation of immunoglobulin genes (GO:0016446)2.53560907
112folic acid-containing compound biosynthetic process (GO:0009396)2.53109090
113regulation of regulatory T cell differentiation (GO:0045589)2.51617765
114rRNA modification (GO:0000154)2.50876195
115chromatin remodeling at centromere (GO:0031055)2.50759077
116protein export from nucleus (GO:0006611)2.50713368
117regulation of spindle checkpoint (GO:0090231)2.49882564
118telomere maintenance via telomere lengthening (GO:0010833)2.49558864
119protein complex disassembly (GO:0043241)2.49508591
1204-hydroxyproline metabolic process (GO:0019471)2.49438608
121positive regulation of chromosome segregation (GO:0051984)2.48630793
122cytidine deamination (GO:0009972)2.48534676
123cytidine metabolic process (GO:0046087)2.48534676
124cytidine catabolic process (GO:0006216)2.48534676
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47527847
126pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.47345643
127positive regulation of cell cycle checkpoint (GO:1901978)2.47196366
128DNA ligation (GO:0006266)2.46391803
129peptidyl-lysine dimethylation (GO:0018027)2.45714815
130innate immune response in mucosa (GO:0002227)2.43913167
131regulation of RNA export from nucleus (GO:0046831)2.43769852
132proline metabolic process (GO:0006560)2.43683733
133pentose-phosphate shunt (GO:0006098)2.42833096
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.42715859
135rRNA processing (GO:0006364)2.42572316
136regulation of spindle organization (GO:0090224)2.42323351
137termination of RNA polymerase III transcription (GO:0006386)2.42119919
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.42119919
139DNA topological change (GO:0006265)2.41382437
140mature B cell differentiation involved in immune response (GO:0002313)2.40436549
141pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.39190901
142peptidyl-arginine methylation (GO:0018216)2.39112134
143peptidyl-arginine N-methylation (GO:0035246)2.39112134
144establishment of viral latency (GO:0019043)2.39052197
145ribonucleoprotein complex biogenesis (GO:0022613)2.38702090
146proline biosynthetic process (GO:0006561)2.38629557
147positive regulation of receptor biosynthetic process (GO:0010870)2.38620128
148apoptotic process involved in morphogenesis (GO:0060561)2.38458771
149nuclear pore complex assembly (GO:0051292)2.37485133
150transcription-coupled nucleotide-excision repair (GO:0006283)2.37393346
151chromosome segregation (GO:0007059)2.36705786
152pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.36536025
153rRNA metabolic process (GO:0016072)2.36153590
154purine nucleobase biosynthetic process (GO:0009113)2.35492213
155lymphocyte homeostasis (GO:0002260)2.35208351
156regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.34817725
157L-serine metabolic process (GO:0006563)2.34290269
158mitotic sister chromatid cohesion (GO:0007064)2.34105137
159cellular response to interleukin-15 (GO:0071350)2.34047151
160mature B cell differentiation (GO:0002335)2.33639309
161translesion synthesis (GO:0019985)2.33623459
162mRNA catabolic process (GO:0006402)2.33191467
163ribosomal large subunit biogenesis (GO:0042273)2.32675960
164pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31587834
165negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31371406
166attachment of spindle microtubules to kinetochore (GO:0008608)2.31201298
167negative regulation of chromosome segregation (GO:0051985)2.30761685
168histone exchange (GO:0043486)2.30579006
169response to interleukin-15 (GO:0070672)2.30454398
170RNA methylation (GO:0001510)2.30428333
171regulation of histone H3-K9 methylation (GO:0051570)2.30329840
172neutrophil activation involved in immune response (GO:0002283)2.30329455
173transcription from mitochondrial promoter (GO:0006390)2.30282689
174viral mRNA export from host cell nucleus (GO:0046784)2.29859138
175macromolecular complex disassembly (GO:0032984)2.29818970
176regulation of exit from mitosis (GO:0007096)2.29607225
177nucleoside salvage (GO:0043174)2.29528462
178protein maturation by protein folding (GO:0022417)2.29065506
179mitotic sister chromatid segregation (GO:0000070)2.28813288
180mitotic chromosome condensation (GO:0007076)2.28608706
181NADPH regeneration (GO:0006740)2.28568570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33324230
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.19455096
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.75540732
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41445305
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.11268191
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96700994
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94394592
8MYC_22102868_ChIP-Seq_BL_Human2.87402393
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80718888
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60954881
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56967324
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53624043
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.45957805
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38174877
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32251995
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.31748711
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31449618
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.28896783
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27977260
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.27150764
21VDR_21846776_ChIP-Seq_THP-1_Human2.24797514
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24344704
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21147813
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.13476047
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11089978
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08833143
27* VDR_23849224_ChIP-Seq_CD4+_Human2.07214036
28* XRN2_22483619_ChIP-Seq_HELA_Human2.03484972
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00013580
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96153253
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95881009
32* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94995842
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94922942
34FOXP3_21729870_ChIP-Seq_TREG_Human1.94824180
35DCP1A_22483619_ChIP-Seq_HELA_Human1.92897635
36CIITA_25753668_ChIP-Seq_RAJI_Human1.89666768
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89588423
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.84349429
39SCL_19346495_ChIP-Seq_HPC-7_Human1.71646518
40MAF_26560356_Chip-Seq_TH1_Human1.70260440
41* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68906545
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66473205
43UTX_26944678_Chip-Seq_JUKART_Human1.66154459
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65447693
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65000572
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62100063
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61755078
48MYB_26560356_Chip-Seq_TH2_Human1.59546472
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58155859
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57753715
51SPI1_23547873_ChIP-Seq_NB4_Human1.56965829
52ZNF263_19887448_ChIP-Seq_K562_Human1.55487074
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54460002
54GABP_19822575_ChIP-Seq_HepG2_Human1.53832555
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53748768
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.53617930
57VDR_24763502_ChIP-Seq_THP-1_Human1.51133490
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.49062594
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49052464
60* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.48618890
61* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48241600
62MYB_26560356_Chip-Seq_TH1_Human1.47995510
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46669355
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45890711
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45638627
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44936651
67AR_21909140_ChIP-Seq_LNCAP_Human1.43354888
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42034079
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.38380731
70KDM5A_27292631_Chip-Seq_BREAST_Human1.38236267
71* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37267506
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35702292
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35666649
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33538725
75* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32259653
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31071180
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30478457
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.29903138
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29377854
80TTF2_22483619_ChIP-Seq_HELA_Human1.29355004
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28347896
82MAF_26560356_Chip-Seq_TH2_Human1.26780737
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26011306
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25767335
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24861196
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24499376
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.24351344
88* LXR_22292898_ChIP-Seq_THP-1_Human1.21312025
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21159238
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20323081
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.19922277
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19500502
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18552517
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18009057
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17904220
96TCF7_22412390_ChIP-Seq_EML_Mouse1.12421257
97RUNX_20019798_ChIP-Seq_JUKART_Human1.11129750
98ELK1_19687146_ChIP-ChIP_HELA_Human1.11069591
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09895449
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09628776
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08176101
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07512449
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07350167
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06952728
105NCOR1_26117541_ChIP-Seq_K562_Human1.05382739
106TFEB_21752829_ChIP-Seq_HELA_Human1.04944479
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04672836
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04324315
109ATF3_27146783_Chip-Seq_COLON_Human1.03827357
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03401733
111* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03310090
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02773396
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01948359
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01680109
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00719572
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99442881
117TET1_21451524_ChIP-Seq_MESCs_Mouse0.99278404
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98154401
119* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97860989
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97611635
121GATA3_27048872_Chip-Seq_THYMUS_Human0.97411006
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96282211
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96265531
124RACK7_27058665_Chip-Seq_MCF-7_Human0.96247559
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96247368
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95571365
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95012637
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93360841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.53511909
2MP0005671_abnormal_response_to3.51452043
3MP0010094_abnormal_chromosome_stability3.23403389
4MP0000685_abnormal_immune_system3.23326306
5MP0003763_abnormal_thymus_physiology3.17690328
6MP0003693_abnormal_embryo_hatching2.89742702
7MP0001800_abnormal_humoral_immune2.87938296
8MP0008260_abnormal_autophagy2.78427185
9MP0003111_abnormal_nucleus_morphology2.64417798
10MP0002398_abnormal_bone_marrow2.64251586
11MP0003077_abnormal_cell_cycle2.61377243
12MP0008007_abnormal_cellular_replicative2.60271626
13MP0004233_abnormal_muscle_weight2.58258767
14MP0001790_abnormal_immune_system2.51256502
15MP0005387_immune_system_phenotype2.51256502
16MP0009333_abnormal_splenocyte_physiolog2.50021148
17MP0001835_abnormal_antigen_presentation2.47018581
18MP0004957_abnormal_blastocyst_morpholog2.43934421
19MP0002420_abnormal_adaptive_immunity2.38191685
20MP0002452_abnormal_antigen_presenting2.36870301
21MP0002396_abnormal_hematopoietic_system2.32571056
22MP0001819_abnormal_immune_cell2.30507467
23MP0000689_abnormal_spleen_morphology2.26493806
24MP0000716_abnormal_immune_system2.21238690
25MP0005410_abnormal_fertilization2.20846100
26MP0002722_abnormal_immune_system2.20809551
27MP0002723_abnormal_immune_serum2.17060331
28MP0005076_abnormal_cell_differentiation2.11755965
29MP0005000_abnormal_immune_tolerance2.10173272
30MP0008058_abnormal_DNA_repair2.09646155
31MP0000703_abnormal_thymus_morphology2.09572409
32MP0008057_abnormal_DNA_replication2.01580069
33MP0002429_abnormal_blood_cell2.00490149
34MP0010307_abnormal_tumor_latency1.98346021
35MP0005058_abnormal_lysosome_morphology1.92581777
36MP0004808_abnormal_hematopoietic_stem1.87298732
37MP0003183_abnormal_peptide_metabolism1.86316306
38MP0005025_abnormal_response_to1.77238933
39MP0006054_spinal_hemorrhage1.73111059
40MP0002405_respiratory_system_inflammati1.71855427
41MP0002933_joint_inflammation1.69469501
42MP0009384_cardiac_valve_regurgitation1.65985217
43MP0002009_preneoplasia1.63503986
44MP0002877_abnormal_melanocyte_morpholog1.63399468
45MP0001873_stomach_inflammation1.63003288
46MP0000465_gastrointestinal_hemorrhage1.58258237
47MP0002166_altered_tumor_susceptibility1.50655120
48MP0001730_embryonic_growth_arrest1.48916971
49MP0002419_abnormal_innate_immunity1.46349799
50MP0003436_decreased_susceptibility_to1.46096342
51MP0004185_abnormal_adipocyte_glucose1.41768482
52MP0000350_abnormal_cell_proliferation1.40293326
53MP0003705_abnormal_hypodermis_morpholog1.39295713
54MP0003656_abnormal_erythrocyte_physiolo1.39139105
55MP0003566_abnormal_cell_adhesion1.36728567
56MP0003303_peritoneal_inflammation1.36575012
57MP0002019_abnormal_tumor_incidence1.34980266
58MP0000733_abnormal_muscle_development1.33351791
59MP0000313_abnormal_cell_death1.33287666
60MP0000015_abnormal_ear_pigmentation1.32686623
61MP0000747_muscle_weakness1.31575465
62MP0005464_abnormal_platelet_physiology1.30376970
63MP0000358_abnormal_cell_content/1.29091737
64MP0006035_abnormal_mitochondrial_morpho1.28648643
65MP0009840_abnormal_foam_cell1.25974249
66MP0009785_altered_susceptibility_to1.25724290
67MP0005623_abnormal_meninges_morphology1.25476509
68MP0003646_muscle_fatigue1.24814858
69MP0008932_abnormal_embryonic_tissue1.24472445
70MP0000490_abnormal_crypts_of1.23915591
71MP0000566_synostosis1.21588101
72MP0001853_heart_inflammation1.20990927
73MP0002086_abnormal_extraembryonic_tissu1.20234091
74MP0003091_abnormal_cell_migration1.20113196
75MP0002163_abnormal_gland_morphology1.19470737
76MP0010155_abnormal_intestine_physiology1.19404305
77MP0003221_abnormal_cardiomyocyte_apopto1.17659008
78MP0001661_extended_life_span1.15312679
79MP0005384_cellular_phenotype1.12286200
80MP0002254_reproductive_system_inflammat1.11504437
81MP0005310_abnormal_salivary_gland1.11303783
82MP0004858_abnormal_nervous_system1.11231151
83MP0004947_skin_inflammation1.10620717
84MP0001845_abnormal_inflammatory_respons1.10519460
85MP0001545_abnormal_hematopoietic_system1.09322854
86MP0005397_hematopoietic_system_phenotyp1.09322854
87MP0002089_abnormal_postnatal_growth/wei1.08283413
88MP0001929_abnormal_gametogenesis1.07839734
89MP0003191_abnormal_cellular_cholesterol1.06784287
90MP0004264_abnormal_extraembryonic_tissu1.04742984
91MP0002148_abnormal_hypersensitivity_rea1.02071315
92MP0003718_maternal_effect1.01970686
93MP0010030_abnormal_orbit_morphology1.01218404
94MP0002638_abnormal_pupillary_reflex0.99421771
95MP0005501_abnormal_skin_physiology0.99382455
96MP0002006_tumorigenesis0.96769370
97MP0002080_prenatal_lethality0.95411101
98MP0003866_abnormal_defecation0.93196196
99MP0001348_abnormal_lacrimal_gland0.92740353
100MP0000858_altered_metastatic_potential0.91904105
101MP0002084_abnormal_developmental_patter0.91786368
102MP0001727_abnormal_embryo_implantation0.91635255
103MP0009278_abnormal_bone_marrow0.91578298
104MP0003453_abnormal_keratinocyte_physiol0.91329821
105MP0003315_abnormal_perineum_morphology0.88450212
106MP0001697_abnormal_embryo_size0.87777928
107MP0004147_increased_porphyrin_level0.87683565
108MP0002234_abnormal_pharynx_morphology0.86749248
109MP0008995_early_reproductive_senescence0.86556157
110MP0000920_abnormal_myelination0.85783326
111MP0003786_premature_aging0.84513220
112MP0003300_gastrointestinal_ulcer0.84429541
113MP0003806_abnormal_nucleotide_metabolis0.83394866
114MP0009053_abnormal_anal_canal0.83037123
115MP0001849_ear_inflammation0.82171992
116MP0002132_abnormal_respiratory_system0.80108367
117MP0002210_abnormal_sex_determination0.79550016
118MP0003698_abnormal_male_reproductive0.79414178
119MP0003279_aneurysm0.78794667
120MP0000678_abnormal_parathyroid_gland0.78541989
121MP0010352_gastrointestinal_tract_polyps0.78113353
122MP0001915_intracranial_hemorrhage0.77742598
123MP0003172_abnormal_lysosome_physiology0.77231615
124MP0001533_abnormal_skeleton_physiology0.76772890
125MP0001145_abnormal_male_reproductive0.75842914
126MP0008877_abnormal_DNA_methylation0.75748203
127MP0004134_abnormal_chest_morphology0.73729714
128MP0005380_embryogenesis_phenotype0.73029476
129MP0001672_abnormal_embryogenesis/_devel0.73029476
130MP0004197_abnormal_fetal_growth/weight/0.71602970
131MP0005023_abnormal_wound_healing0.70472189
132MP0005621_abnormal_cell_physiology0.69683931
133MP0002095_abnormal_skin_pigmentation0.68810881
134MP0003984_embryonic_growth_retardation0.67783546
135MP0003950_abnormal_plasma_membrane0.67722023
136MP0006082_CNS_inflammation0.63675307
137MP0003448_altered_tumor_morphology0.63320168
138MP0002088_abnormal_embryonic_growth/wei0.62961333
139MP0008469_abnormal_protein_level0.61645927
140MP0005408_hypopigmentation0.61091615
141MP0005174_abnormal_tail_pigmentation0.60783652
142MP0002085_abnormal_embryonic_tissue0.58667906
143MP0009672_abnormal_birth_weight0.58651849

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)4.84286069
2Agammaglobulinemia (HP:0004432)4.40209897
3Chronic otitis media (HP:0000389)4.30865392
4Recurrent sinusitis (HP:0011108)4.12142059
5Sparse lateral eyebrow (HP:0005338)3.84652036
6Thyroiditis (HP:0100646)3.73886718
7Anal stenosis (HP:0002025)3.71893173
8Birth length less than 3rd percentile (HP:0003561)3.70756835
9Severe combined immunodeficiency (HP:0004430)3.59704378
10Abnormality of the fingertips (HP:0001211)3.54566887
11Abnormality of cells of the erythroid lineage (HP:0012130)3.50311507
12T lymphocytopenia (HP:0005403)3.49258083
13Elevated erythrocyte sedimentation rate (HP:0003565)3.41490465
14Thrombocytosis (HP:0001894)3.37853850
15Hypoplasia of the thymus (HP:0000778)3.32456423
16Abnormal number of erythroid precursors (HP:0012131)3.31635403
17Cerebral hypomyelination (HP:0006808)3.30133517
18Small epiphyses (HP:0010585)3.27211752
19Squamous cell carcinoma (HP:0002860)3.24540217
20Bronchitis (HP:0012387)3.23659408
21Abnormality of T cell number (HP:0011839)3.23400544
22Combined immunodeficiency (HP:0005387)3.20420116
23Lymphopenia (HP:0001888)3.08905713
24Hypoplasia of the capital femoral epiphysis (HP:0003090)3.05539040
25Chronic sinusitis (HP:0011109)3.05278594
26Autoimmune thrombocytopenia (HP:0001973)3.03604399
27IgM deficiency (HP:0002850)3.03564932
28Muscle fiber atrophy (HP:0100295)3.01525506
29Recurrent viral infections (HP:0004429)2.99932812
30Microvesicular hepatic steatosis (HP:0001414)2.94853198
31Abnormality of cells of the lymphoid lineage (HP:0012140)2.90823730
32Nasal polyposis (HP:0100582)2.90302862
33Long palpebral fissure (HP:0000637)2.87938212
34IgG deficiency (HP:0004315)2.86070222
35Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.85311953
36Absent epiphyses (HP:0010577)2.85311953
37Type 2 muscle fiber atrophy (HP:0003554)2.85266002
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.82368007
39Cellulitis (HP:0100658)2.80824821
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79263201
41Colitis (HP:0002583)2.76794421
42Abnormality of T cells (HP:0002843)2.75954627
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75559226
44B lymphocytopenia (HP:0010976)2.73101813
45Abnormality of B cell number (HP:0010975)2.73101813
46Progressive muscle weakness (HP:0003323)2.72297909
47Recurrent cutaneous fungal infections (HP:0011370)2.69561245
48Chronic mucocutaneous candidiasis (HP:0002728)2.69561245
49Recurrent otitis media (HP:0000403)2.68968893
50IgA deficiency (HP:0002720)2.67941684
51Fatigue (HP:0012378)2.67051889
52Intestinal fistula (HP:0100819)2.61660981
53Rough bone trabeculation (HP:0100670)2.51703924
54Ulnar deviation of the wrist (HP:0003049)2.46837017
55Hyperacusis (HP:0010780)2.44931118
56Recurrent fungal infections (HP:0002841)2.44424898
57Meningitis (HP:0001287)2.44244852
58Papilloma (HP:0012740)2.37803398
59Verrucae (HP:0200043)2.37803398
60Progressive external ophthalmoplegia (HP:0000590)2.36971256
61Abnormality of T cell physiology (HP:0011840)2.36458812
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36026440
63Selective tooth agenesis (HP:0001592)2.34724488
6411 pairs of ribs (HP:0000878)2.32841701
65Short 5th finger (HP:0009237)2.31483732
66Panhypogammaglobulinemia (HP:0003139)2.30710254
67Flat acetabular roof (HP:0003180)2.28793670
68Chromsome breakage (HP:0040012)2.25356327
69Lower limb hyperreflexia (HP:0002395)2.21765483
70Abnormality of the nasal mucosa (HP:0000433)2.19680355
71Abnormality of the calcaneus (HP:0008364)2.17645766
72Leiomyosarcoma (HP:0100243)2.17531573
73Uterine leiomyosarcoma (HP:0002891)2.17531573
74Multiple enchondromatosis (HP:0005701)2.17313354
75Abnormal trabecular bone morphology (HP:0100671)2.17248362
76Renal cell carcinoma (HP:0005584)2.16294268
77Gastrointestinal stroma tumor (HP:0100723)2.15621551
78Ectopic kidney (HP:0000086)2.15247004
79Poikiloderma (HP:0001029)2.13918389
80Flattened epiphyses (HP:0003071)2.13794848
81Broad distal phalanx of finger (HP:0009836)2.13681868
82Recurrent abscess formation (HP:0002722)2.13565819
83Recurrent pneumonia (HP:0006532)2.12273844
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11750219
85Lymphoma (HP:0002665)2.11446731
86Aplasia/Hypoplasia of the thymus (HP:0010515)2.10851808
87Hypertensive crisis (HP:0100735)2.10380397
88Long clavicles (HP:0000890)2.10029179
89Self-mutilation (HP:0000742)2.09684779
90Ragged-red muscle fibers (HP:0003200)2.08437006
91Aortic valve stenosis (HP:0001650)2.07726440
92Deep palmar crease (HP:0006191)2.02984144
93CNS hypomyelination (HP:0003429)2.02966370
94Bone marrow hypocellularity (HP:0005528)2.02741075
95Hypoplastic pelvis (HP:0008839)2.02275692
96Ureteral stenosis (HP:0000071)2.01780365
97Calcaneovalgus deformity (HP:0001848)2.00083399
98Viral hepatitis (HP:0006562)1.99981124
99Irregular vertebral endplates (HP:0003301)1.98989746
100Petechiae (HP:0000967)1.98936710
101Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98291312
102Myelodysplasia (HP:0002863)1.97200900
103Recurrent bacterial skin infections (HP:0005406)1.97079429
104Cafe-au-lait spot (HP:0000957)1.96976705
105Premature skin wrinkling (HP:0100678)1.96599913
106Sepsis (HP:0100806)1.96475603
107Flat capital femoral epiphysis (HP:0003370)1.95130300
108Natal tooth (HP:0000695)1.94998500
109Lip pit (HP:0100267)1.94852249
110Gastrointestinal inflammation (HP:0004386)1.94291674
111Abnormality of the thoracic spine (HP:0100711)1.93615821
112Myositis (HP:0100614)1.93586227
113Myocardial infarction (HP:0001658)1.92957809
114Abnormality of the preputium (HP:0100587)1.92447238
115Carpal bone hypoplasia (HP:0001498)1.91736111
116Irregular epiphyses (HP:0010582)1.91556058
117Abnormality of eosinophils (HP:0001879)1.91123652
118Depressed nasal tip (HP:0000437)1.90742240
119Meckel diverticulum (HP:0002245)1.90668973
120Progressive hearing impairment (HP:0001730)1.90479539
121Recurrent skin infections (HP:0001581)1.90437718
122High pitched voice (HP:0001620)1.89853942
123Basal cell carcinoma (HP:0002671)1.87238728
124Ureteral obstruction (HP:0006000)1.86382935
125Leukocytosis (HP:0001974)1.86151024
126Coxa valga (HP:0002673)1.85602300
127Inflammation of the large intestine (HP:0002037)1.85222721
128Thoracic kyphosis (HP:0002942)1.85015534
129Recurrent lower respiratory tract infections (HP:0002783)1.84521552
130Leukopenia (HP:0001882)1.84479629
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84115753
132Stillbirth (HP:0003826)1.83949925
133Entropion (HP:0000621)1.83918385
134High anterior hairline (HP:0009890)1.83352779
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.83202611
136Slender long bone (HP:0003100)1.83016375
137Abnormal gallbladder physiology (HP:0012438)1.82642109
138Cholecystitis (HP:0001082)1.82642109
139Broad face (HP:0000283)1.82290551
140Upper motor neuron abnormality (HP:0002127)1.81759469
141Chronic diarrhea (HP:0002028)1.81018214
142Macrocytic anemia (HP:0001972)1.80056739
143Vertebral compression fractures (HP:0002953)1.79770876
144Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.79730547
145Trismus (HP:0000211)1.79623964
146Nemaline bodies (HP:0003798)1.79475664
147Hypergonadotropic hypogonadism (HP:0000815)1.79112608
148Patellar aplasia (HP:0006443)1.78855150
149Deformed tarsal bones (HP:0008119)1.77733227
150Abnormality of the umbilical cord (HP:0010881)1.76049695
151Ulnar bowing (HP:0003031)1.75881212
152Abnormality of the ileum (HP:0001549)1.75194117
153Facial cleft (HP:0002006)1.74797815
154Prominent nose (HP:0000448)1.74468186
155Progressive sensorineural hearing impairment (HP:0000408)1.74376410
156Barrel-shaped chest (HP:0001552)1.73713387
157Small intestinal stenosis (HP:0012848)1.73690680
158Duodenal stenosis (HP:0100867)1.73690680
159Restrictive lung disease (HP:0002091)1.73620644
160Acute hepatic failure (HP:0006554)1.73383806
161Deviation of the thumb (HP:0009603)1.73195824
162Abnormality of the distal phalanges of the toes (HP:0010182)1.73016802
163Easy fatigability (HP:0003388)1.72988237
164Stomatitis (HP:0010280)1.72637691
165Micronodular cirrhosis (HP:0001413)1.72251325
166Abnormality of chromosome stability (HP:0003220)1.71871748
167Malignant gastrointestinal tract tumors (HP:0006749)1.70770993
168Gastrointestinal carcinoma (HP:0002672)1.70770993
169Resting tremor (HP:0002322)1.70005019
170Obstructive lung disease (HP:0006536)1.69088260
171Proximal placement of thumb (HP:0009623)1.69082499
172Insomnia (HP:0100785)1.69067532
173Ureteral duplication (HP:0000073)1.66063579
174Abnormality of DNA repair (HP:0003254)1.65712635
175Abnormality of the columella (HP:0009929)1.64629902
176Dysmetric saccades (HP:0000641)1.63624401
177Breast hypoplasia (HP:0003187)1.62596321
178Transitional cell carcinoma of the bladder (HP:0006740)1.62542283
179Slow saccadic eye movements (HP:0000514)1.62169747
180Dislocated radial head (HP:0003083)1.61324056
181Sandal gap (HP:0001852)1.61144454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.79177421
2TESK23.44832841
3SMG13.39179996
4ZAK3.32328548
5MAP3K103.17561552
6IRAK33.08531823
7NME22.86901255
8EIF2AK12.78479114
9EIF2AK32.68007442
10NEK22.47945954
11PRPF4B2.46569278
12BUB12.44972315
13FGFR22.40609840
14ERN12.39389808
15ICK2.36936175
16SRPK12.25926513
17CDC72.10578990
18STK102.06349603
19CLK12.02356715
20STK241.83176858
21MAP3K31.77342302
22EPHA21.68666539
23ITK1.60969650
24WEE11.58790828
25PBK1.58522763
26PASK1.56225679
27BTK1.54436503
28ZAP701.53146829
29BLK1.45540146
30FGFR41.44970862
31TESK11.44744467
32TYK21.43538908
33CSF1R1.41862227
34CCNB11.37775569
35TXK1.37694547
36CAMK1D1.37381971
37SYK1.35581149
38EEF2K1.33133309
39TYRO31.31218609
40TRIB31.29836018
41KDR1.27909406
42MAP2K31.24629576
43PLK41.23972509
44GRK61.23820219
45LRRK21.23704353
46BRAF1.23109084
47VRK11.15566689
48JAK31.09295480
49CDK81.07435245
50DYRK31.07206317
51TTK1.06735330
52CDK121.05871488
53STK161.02541834
54DAPK31.00058755
55MAP3K80.99682346
56MST1R0.99372867
57ATR0.98173382
58HCK0.96285785
59LCK0.94781973
60IRAK40.94194546
61LYN0.93986435
62MAP3K20.93954437
63AURKB0.93631226
64PIM20.93068515
65MKNK10.92702195
66MAPK110.91416077
67CDK90.90418423
68LIMK10.87907522
69CAMK1G0.87518190
70CDK40.87239504
71TAOK20.86669518
72ACVR1B0.86477172
73SCYL20.85048684
74BRSK20.84968401
75TLK10.84648217
76RPS6KB20.80615089
77VRK20.80241502
78TBK10.79448187
79NEK90.78996001
80MTOR0.78529588
81PIM10.77904181
82MAP3K140.75732693
83RPS6KC10.74033957
84RPS6KL10.74033957
85PAK40.74000654
86CHEK20.72779299
87PLK10.72509820
88LATS20.72333073
89NEK10.71992847
90CDK70.71478553
91SIK30.71039601
92IKBKE0.70812474
93PDK40.69004114
94PDK30.69004114
95ARAF0.68877355
96TSSK60.68788898
97BRD40.68626663
98SIK10.66504731
99CAMK40.63493891
100CHEK10.62889481
101PDGFRB0.62788919
102MAP3K110.62615029
103BRSK10.61594960
104DYRK1A0.60474649
105FES0.59865378
106ILK0.59243254
107DYRK1B0.56992313
108DDR20.56531467
109TEC0.56354988
110KIT0.56345457
111IKBKB0.56322267
112MUSK0.55986743
113AURKA0.55757994
114TAF10.54766534
115RPS6KA60.52975367
116MKNK20.52129946
117AKT20.51372391
118MARK30.50733938
119TTN0.50303605
120NME10.46997904
121BMX0.46482223
122IRAK20.46396267
123FGFR10.45461388
124DAPK10.45366154
125RPS6KA50.44505911
126YES10.44187568
127TGFBR10.43795114
128TRPM70.43017592
129PDK20.42794757
130PDPK10.42283731
131MELK0.42223549
132CDK10.41797476
133STK40.41493237
134ALK0.40628813
135TNK20.40411847
136RPS6KA20.40009880
137PAK20.39772342
138CDK20.38552738
139EPHB10.36608067
140PIK3CG0.36518556
141MST40.36404524
142PAK10.35332888
143MAP2K20.35301827
144CDK60.35121241
145FGFR30.33461730
146ATM0.33410292
147PRKCQ0.32940482
148KSR20.31249610

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.03993490
2Primary immunodeficiency_Homo sapiens_hsa053403.30816767
3Mismatch repair_Homo sapiens_hsa034303.13945966
4Ribosome_Homo sapiens_hsa030102.86521008
5Non-homologous end-joining_Homo sapiens_hsa034502.71445774
6Spliceosome_Homo sapiens_hsa030402.66332545
7RNA polymerase_Homo sapiens_hsa030202.51589412
8Nucleotide excision repair_Homo sapiens_hsa034202.50840055
9Proteasome_Homo sapiens_hsa030502.50276392
10Base excision repair_Homo sapiens_hsa034102.43416939
11Homologous recombination_Homo sapiens_hsa034402.27971236
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27385624
13Pyrimidine metabolism_Homo sapiens_hsa002402.24576457
14Protein export_Homo sapiens_hsa030602.03246725
15Cell cycle_Homo sapiens_hsa041101.97719112
16Antigen processing and presentation_Homo sapiens_hsa046121.97126179
17B cell receptor signaling pathway_Homo sapiens_hsa046621.90273336
18RNA transport_Homo sapiens_hsa030131.87944596
19Fanconi anemia pathway_Homo sapiens_hsa034601.87480167
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80565626
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.68728824
22Other glycan degradation_Homo sapiens_hsa005111.60717887
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55895850
24Basal transcription factors_Homo sapiens_hsa030221.47518174
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.44993978
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42684136
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40363012
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37151341
29RNA degradation_Homo sapiens_hsa030181.36122149
30Hematopoietic cell lineage_Homo sapiens_hsa046401.35596733
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35232209
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33986571
33p53 signaling pathway_Homo sapiens_hsa041151.31987610
34One carbon pool by folate_Homo sapiens_hsa006701.30791177
35Measles_Homo sapiens_hsa051621.29492201
36Pentose phosphate pathway_Homo sapiens_hsa000301.29376398
37Steroid biosynthesis_Homo sapiens_hsa001001.29270925
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28883492
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27801234
40Epstein-Barr virus infection_Homo sapiens_hsa051691.20207221
41Lysine degradation_Homo sapiens_hsa003101.17679303
42Purine metabolism_Homo sapiens_hsa002301.15339887
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15064418
44T cell receptor signaling pathway_Homo sapiens_hsa046601.10243538
45Viral carcinogenesis_Homo sapiens_hsa052031.07514342
46N-Glycan biosynthesis_Homo sapiens_hsa005101.06383226
47Pancreatic cancer_Homo sapiens_hsa052121.04359577
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04117934
49Fructose and mannose metabolism_Homo sapiens_hsa000511.02552236
50Herpes simplex infection_Homo sapiens_hsa051681.01322878
51Carbon metabolism_Homo sapiens_hsa012001.01118966
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.00835070
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00706597
54Galactose metabolism_Homo sapiens_hsa000520.97307579
55Apoptosis_Homo sapiens_hsa042100.97204336
56Systemic lupus erythematosus_Homo sapiens_hsa053220.97071060
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94677464
58Sulfur relay system_Homo sapiens_hsa041220.94038082
59mRNA surveillance pathway_Homo sapiens_hsa030150.91774776
60HTLV-I infection_Homo sapiens_hsa051660.88105646
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84999395
62Thyroid cancer_Homo sapiens_hsa052160.83678330
63Prostate cancer_Homo sapiens_hsa052150.81516390
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78227704
65Shigellosis_Homo sapiens_hsa051310.77719941
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.75117769
67Sphingolipid metabolism_Homo sapiens_hsa006000.74544323
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72573518
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72092445
70Osteoclast differentiation_Homo sapiens_hsa043800.68383137
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68370728
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68081975
73Endometrial cancer_Homo sapiens_hsa052130.66774631
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65558912
75Viral myocarditis_Homo sapiens_hsa054160.64863178
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63413771
77Inositol phosphate metabolism_Homo sapiens_hsa005620.62593201
78Vitamin B6 metabolism_Homo sapiens_hsa007500.60882500
79Selenocompound metabolism_Homo sapiens_hsa004500.59692863
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59033899
81HIF-1 signaling pathway_Homo sapiens_hsa040660.58940885
82Arginine biosynthesis_Homo sapiens_hsa002200.58655552
83Leishmaniasis_Homo sapiens_hsa051400.58116318
84Renin-angiotensin system_Homo sapiens_hsa046140.56994492
85Hepatitis B_Homo sapiens_hsa051610.56216837
86Glioma_Homo sapiens_hsa052140.55105195
87Legionellosis_Homo sapiens_hsa051340.53996925
88Malaria_Homo sapiens_hsa051440.52920826
89Lysosome_Homo sapiens_hsa041420.51966186
90Small cell lung cancer_Homo sapiens_hsa052220.51890267
91Fatty acid biosynthesis_Homo sapiens_hsa000610.51649811
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51615952
93Biosynthesis of amino acids_Homo sapiens_hsa012300.50496752
94TNF signaling pathway_Homo sapiens_hsa046680.50455992
95Hepatitis C_Homo sapiens_hsa051600.49349959
96Insulin signaling pathway_Homo sapiens_hsa049100.49337684
97MicroRNAs in cancer_Homo sapiens_hsa052060.49277857
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.48316968
99Renal cell carcinoma_Homo sapiens_hsa052110.47470609
100Arginine and proline metabolism_Homo sapiens_hsa003300.46910287
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.46652620
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46497899
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46118913
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.43431262
105Chronic myeloid leukemia_Homo sapiens_hsa052200.42659859
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42414547
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42111594
108Tuberculosis_Homo sapiens_hsa051520.41875043
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41230654
110Influenza A_Homo sapiens_hsa051640.40929424
111Proteoglycans in cancer_Homo sapiens_hsa052050.40119709
112Non-small cell lung cancer_Homo sapiens_hsa052230.38291607
113AMPK signaling pathway_Homo sapiens_hsa041520.36269043
114Folate biosynthesis_Homo sapiens_hsa007900.35522473
115Asthma_Homo sapiens_hsa053100.31594599
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29888135
117Platelet activation_Homo sapiens_hsa046110.28071220
118Bladder cancer_Homo sapiens_hsa052190.27029979
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26869276
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.24302661
121Chemokine signaling pathway_Homo sapiens_hsa040620.23297087
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22877697
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.22525805
124Acute myeloid leukemia_Homo sapiens_hsa052210.21687591
125Ether lipid metabolism_Homo sapiens_hsa005650.21564115
126Notch signaling pathway_Homo sapiens_hsa043300.21351967
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21312831
128Colorectal cancer_Homo sapiens_hsa052100.21251090
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.21219247
130Alcoholism_Homo sapiens_hsa050340.20482295
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19929985
132Toxoplasmosis_Homo sapiens_hsa051450.18843356
133Allograft rejection_Homo sapiens_hsa053300.18842113

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