CCDC136

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.85223452
2plasma membrane fusion (GO:0045026)9.80706456
3axonemal dynein complex assembly (GO:0070286)9.73720016
4cell-cell recognition (GO:0009988)9.69472527
5epithelial cilium movement (GO:0003351)9.31582754
6spermatid development (GO:0007286)9.07772196
7motile cilium assembly (GO:0044458)8.80473016
8reproduction (GO:0000003)8.57241378
9piRNA metabolic process (GO:0034587)8.39973211
10regulation of cilium movement (GO:0003352)8.26577719
11cilium movement (GO:0003341)7.99697765
12male meiosis (GO:0007140)7.92626062
13synaptonemal complex organization (GO:0070193)7.65052980
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.59077619
15synaptonemal complex assembly (GO:0007130)7.36836192
16single fertilization (GO:0007338)6.96889504
17sperm capacitation (GO:0048240)6.81872249
18negative regulation of inclusion body assembly (GO:0090084)6.47287199
19spermatogenesis (GO:0007283)6.11777703
20male gamete generation (GO:0048232)6.09470052
21fertilization (GO:0009566)6.05647886
22gamete generation (GO:0007276)5.60039462
23calcium ion-dependent exocytosis (GO:0017156)5.54943758
24ventricular system development (GO:0021591)5.53323619
25organic cation transport (GO:0015695)5.51008606
26DNA methylation involved in gamete generation (GO:0043046)5.45978755
27regulation of inclusion body assembly (GO:0090083)5.34880145
28microtubule depolymerization (GO:0007019)5.32405097
29male meiosis I (GO:0007141)5.31121562
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.28309245
31germ cell development (GO:0007281)5.22362946
32regulation of microtubule-based movement (GO:0060632)5.12853005
33microtubule severing (GO:0051013)5.05908314
34chromosome organization involved in meiosis (GO:0070192)4.97845603
35cell recognition (GO:0008037)4.96221701
36seminiferous tubule development (GO:0072520)4.72227791
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.65933419
38meiotic nuclear division (GO:0007126)4.59795529
39synaptic vesicle maturation (GO:0016188)4.51385206
40left/right pattern formation (GO:0060972)4.41784378
41multicellular organismal reproductive process (GO:0048609)4.40674619
42regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36811296
43locomotory exploration behavior (GO:0035641)4.35694490
44protein localization to cilium (GO:0061512)4.25904447
45meiosis I (GO:0007127)4.22909523
46regulation of synaptic vesicle exocytosis (GO:2000300)4.21635822
47glutamate secretion (GO:0014047)4.20966412
48postsynaptic membrane organization (GO:0001941)4.14524164
49response to pheromone (GO:0019236)4.10342345
50synaptic vesicle docking involved in exocytosis (GO:0016081)4.09550297
51spermatid nucleus differentiation (GO:0007289)4.08731260
52protein polyglutamylation (GO:0018095)4.06299345
53protein localization to synapse (GO:0035418)4.02096598
54synaptic vesicle exocytosis (GO:0016079)4.00654783
55chromosome condensation (GO:0030261)3.85091125
56neuronal ion channel clustering (GO:0045161)3.83276310
57DNA packaging (GO:0006323)3.77144267
58neurofilament cytoskeleton organization (GO:0060052)3.73458663
59neuron cell-cell adhesion (GO:0007158)3.69350167
60genitalia morphogenesis (GO:0035112)3.67489158
61chaperone-mediated protein complex assembly (GO:0051131)3.64917957
62glycerol ether metabolic process (GO:0006662)3.62619579
63negative regulation of organelle assembly (GO:1902116)3.62086927
64exploration behavior (GO:0035640)3.61840146
65regulation of synaptic vesicle transport (GO:1902803)3.61777804
66monoubiquitinated protein deubiquitination (GO:0035520)3.59019239
67meiotic cell cycle (GO:0051321)3.58658291
68multicellular organismal development (GO:0007275)3.58507966
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56530147
70presynaptic membrane organization (GO:0097090)3.54550294
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52649567
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52323751
73presynaptic membrane assembly (GO:0097105)3.50531343
74ionotropic glutamate receptor signaling pathway (GO:0035235)3.50115270
75axonal fasciculation (GO:0007413)3.44363202
76vocalization behavior (GO:0071625)3.43911185
77intraciliary transport (GO:0042073)3.43176483
78cell migration in hindbrain (GO:0021535)3.38249991
79sodium ion export (GO:0071436)3.37619530
80ether metabolic process (GO:0018904)3.36858192
81synaptic transmission, glutamatergic (GO:0035249)3.33740117
82neurotransmitter-gated ion channel clustering (GO:0072578)3.31857912
83neuron recognition (GO:0008038)3.31197067
84transmission of nerve impulse (GO:0019226)3.30822870
85microtubule-based movement (GO:0007018)3.30039207
86positive regulation of membrane potential (GO:0045838)3.27760663
87cellular potassium ion homeostasis (GO:0030007)3.25708867
88pyrimidine nucleobase catabolic process (GO:0006208)3.25333181
89axoneme assembly (GO:0035082)3.25305615
90dendritic spine morphogenesis (GO:0060997)3.23611588
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20845200
92cerebral cortex neuron differentiation (GO:0021895)3.18655918
93neurotransmitter secretion (GO:0007269)3.16177884
94neuromuscular synaptic transmission (GO:0007274)3.08954315
95carnitine transport (GO:0015879)3.07918142
96amino-acid betaine transport (GO:0015838)3.07918142
97cilium organization (GO:0044782)3.07480409
98regulation of spindle checkpoint (GO:0090231)3.07051645
99positive regulation of synapse maturation (GO:0090129)3.05051592
100protein refolding (GO:0042026)3.04117559
101gene silencing by RNA (GO:0031047)3.02996496
102glutamate receptor signaling pathway (GO:0007215)3.02828368
103regulation of neuronal synaptic plasticity (GO:0048168)3.01950102
104carnitine transmembrane transport (GO:1902603)3.01092410
105glycolytic process (GO:0006096)3.00969358
106regulation of glutamate receptor signaling pathway (GO:1900449)3.00228958
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.99588225
108neuron-neuron synaptic transmission (GO:0007270)2.98797173
109establishment of mitochondrion localization (GO:0051654)2.98710560
110cerebellar granule cell differentiation (GO:0021707)2.98562987
111lactate metabolic process (GO:0006089)2.97681147
112phosphatidylethanolamine biosynthetic process (GO:0006646)2.95755946
113neuromuscular process controlling balance (GO:0050885)2.94111078
114meiotic cell cycle process (GO:1903046)2.93213274
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93103330
116cilium assembly (GO:0042384)2.92235218
117protein targeting to Golgi (GO:0000042)2.91785377
118cellular component assembly involved in morphogenesis (GO:0010927)2.87854430
119sequestering of actin monomers (GO:0042989)2.87790979
120positive regulation of dendritic spine development (GO:0060999)2.87434730
121neuronal action potential propagation (GO:0019227)2.85978279
122synapsis (GO:0007129)2.85925550
123nucleosome disassembly (GO:0006337)2.85447235
124protein-DNA complex disassembly (GO:0032986)2.85447235
125polyol catabolic process (GO:0046174)2.83882334
126establishment of protein localization to Golgi (GO:0072600)2.83534715
127cerebellar Purkinje cell differentiation (GO:0021702)2.82983438
128cranial nerve morphogenesis (GO:0021602)2.82643931
129cilium morphogenesis (GO:0060271)2.82514273
130adult walking behavior (GO:0007628)2.82345470
131regulation of postsynaptic membrane potential (GO:0060078)2.81393235
132protein K11-linked deubiquitination (GO:0035871)2.81098789
133phosphatidylethanolamine metabolic process (GO:0046337)2.78723003
134single strand break repair (GO:0000012)2.77883678
135regulation of centriole replication (GO:0046599)2.77556070
136retrograde transport, vesicle recycling within Golgi (GO:0000301)2.76745513
137regulation of synapse structural plasticity (GO:0051823)2.76430931
138long-term memory (GO:0007616)2.76149892
139RNA localization (GO:0006403)2.74632912
140regulation of neurotransmitter secretion (GO:0046928)2.74441537
141mitotic sister chromatid cohesion (GO:0007064)2.74397827
142nucleus organization (GO:0006997)2.73807778
143dendritic spine organization (GO:0097061)2.73434040
144microtubule polymerization or depolymerization (GO:0031109)2.72678629
145chromatin silencing (GO:0006342)2.72415435
146regulation of transcription involved in cell fate commitment (GO:0060850)2.70631055
147rRNA methylation (GO:0031167)2.69877858
148membrane depolarization (GO:0051899)2.69670651
149regulation of meiosis I (GO:0060631)2.68175985
150auditory behavior (GO:0031223)2.67038175
151membrane depolarization during action potential (GO:0086010)2.66663218
152calcium ion import (GO:0070509)2.64240202
153nucleoside diphosphate phosphorylation (GO:0006165)2.64006813
154sexual reproduction (GO:0019953)2.60259183
155alditol metabolic process (GO:0019400)2.58555006
156peptidyl-glutamic acid modification (GO:0018200)2.56973061
157nuclear pore complex assembly (GO:0051292)2.55101410
158regulation of cilium assembly (GO:1902017)2.52923705
159positive regulation of macrophage activation (GO:0043032)2.46411827
160gene silencing (GO:0016458)2.44071456
161regulation of protein polyubiquitination (GO:1902914)2.39363397
162fusion of sperm to egg plasma membrane (GO:0007342)12.7134822
163sperm motility (GO:0030317)12.4120827
164cilium or flagellum-dependent cell motility (GO:0001539)11.5577715
165acrosome assembly (GO:0001675)11.1546686
166acrosome reaction (GO:0007340)11.1158585
167cell wall macromolecule metabolic process (GO:0044036)10.9395496
168cell wall macromolecule catabolic process (GO:0016998)10.9395496
169sperm-egg recognition (GO:0035036)10.8583152
170multicellular organism reproduction (GO:0032504)10.2780772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.11904907
2EZH2_22144423_ChIP-Seq_EOC_Human5.89147005
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.08670078
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.29981452
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00155414
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96669585
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.78775323
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76260895
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.47074077
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41209882
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40079016
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35509585
13ZNF274_21170338_ChIP-Seq_K562_Hela2.29224929
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14300265
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11117570
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11117570
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09660193
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07393256
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.05926445
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.00515209
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00444024
22GBX2_23144817_ChIP-Seq_PC3_Human1.99581249
23VDR_22108803_ChIP-Seq_LS180_Human1.97793768
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.96109948
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91370063
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.90624103
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86768263
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83508564
29REST_21632747_ChIP-Seq_MESCs_Mouse1.82761079
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82253070
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80371341
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.77258802
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76903874
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74750694
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68549576
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68346274
37CTCF_27219007_Chip-Seq_Bcells_Human1.64790257
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64768206
39* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58220960
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55464410
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.55042279
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54428154
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53692267
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.52436736
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49982278
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49692649
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49439360
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49300947
49CBP_20019798_ChIP-Seq_JUKART_Human1.49300947
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46008780
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45921031
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43073149
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42885102
54STAT1_17558387_ChIP-Seq_HELA_Human1.38140807
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38038831
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36289769
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35768236
58KDM2B_26808549_Chip-Seq_REH_Human1.32152042
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.30745790
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29690211
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29095179
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.28778602
63FUS_26573619_Chip-Seq_HEK293_Human1.28290531
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28168169
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25905406
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.25208686
67AR_21572438_ChIP-Seq_LNCaP_Human1.25066925
68GATA3_21867929_ChIP-Seq_CD8_Mouse1.23479528
69LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20874959
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19182107
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19138278
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19138278
73RNF2_27304074_Chip-Seq_NSC_Mouse1.18935447
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15816768
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.15069946
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14077126
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.13273698
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12581907
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12454330
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12247543
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11608653
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09964537
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.09248652
84P53_21459846_ChIP-Seq_SAOS-2_Human1.09185912
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08896997
86* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08741960
87P300_19829295_ChIP-Seq_ESCs_Human1.08266359
88GF1_26923725_Chip-Seq_HPCs_Mouse1.07945554
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07538888
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.06905568
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06699582
92CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05974090
93AR_25329375_ChIP-Seq_VCAP_Human1.05870364
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04751932
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04668869
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04637753
97TAF15_26573619_Chip-Seq_HEK293_Human1.04478924
98GATA3_21867929_ChIP-Seq_TH1_Mouse1.04368696
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04072184
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03982311
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.03395033
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03328430
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01758329
104AR_19668381_ChIP-Seq_PC3_Human1.01339132
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00598401
106KDM2B_26808549_Chip-Seq_K562_Human1.00569055
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00258117
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98680408
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98616677
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97883390
111MYC_27129775_Chip-Seq_CORNEA_Mouse0.97068296
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96785421
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.96453187
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96239169
115* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96184978
116SOX2_21211035_ChIP-Seq_LN229_Gbm0.95863270
117SOX9_26525672_Chip-Seq_HEART_Mouse0.94989346
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94723785
119STAT3_23295773_ChIP-Seq_U87_Human0.94560948
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94253824
121SMC4_20622854_ChIP-Seq_HELA_Human0.93905817
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.93437186
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.93409867
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93019716
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92909611
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92590771
127P53_22387025_ChIP-Seq_ESCs_Mouse0.91659647
128OCT4_18555785_Chip-Seq_ESCs_Mouse0.91277973
129OCT4_19829295_ChIP-Seq_ESCs_Human0.91131197
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90867005
131REST_18959480_ChIP-ChIP_MESCs_Mouse0.90545462
132TCF4_23295773_ChIP-Seq_U87_Human0.90425114
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90360430
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.90247698
135ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89806290
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89794858
137DROSHA_22980978_ChIP-Seq_HELA_Human0.89583722
138RUNX2_22187159_ChIP-Seq_PCA_Human0.89013343
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.88840561
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88712891
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.88454798
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.87481232
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87230988
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87226731
145ERA_21632823_ChIP-Seq_H3396_Human0.87086621
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.87022866
147TBL1_22424771_ChIP-Seq_293T_Human0.87019017
148ERG_20517297_ChIP-Seq_VCAP_Human0.86825862
149SMAD4_21799915_ChIP-Seq_A2780_Human0.86568471
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86203839
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84945639
152P300_18555785_Chip-Seq_ESCs_Mouse0.84773573
153MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.84473178
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84218100
155KLF4_18555785_Chip-Seq_ESCs_Mouse0.83769318
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83682031
157SOX2_21211035_ChIP-Seq_LN229_Human0.83491294
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.82966056
159P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82730539
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.82346363
161KLF4_19829295_ChIP-Seq_ESCs_Human0.81974552
162ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81948615
163STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81759834
164* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81471224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.65538444
2MP0001929_abnormal_gametogenesis5.05220253
3MP0008877_abnormal_DNA_methylation4.68140964
4MP0002210_abnormal_sex_determination3.29677355
5MP0002653_abnormal_ependyma_morphology3.15606311
6MP0002161_abnormal_fertility/fecundity3.06429392
7MP0001145_abnormal_male_reproductive2.80324875
8MP0000653_abnormal_sex_gland2.42870848
9MP0005623_abnormal_meninges_morphology2.08185380
10MP0005670_abnormal_white_adipose2.02515770
11MP0005410_abnormal_fertilization14.5368879
12MP0009046_muscle_twitch1.97002579
13MP0002160_abnormal_reproductive_system1.96626130
14MP0003122_maternal_imprinting1.82276863
15MP0006292_abnormal_olfactory_placode1.73640172
16MP0003646_muscle_fatigue1.70773498
17MP0004233_abnormal_muscle_weight1.64648748
18MP0001970_abnormal_pain_threshold1.57894087
19MP0001984_abnormal_olfaction1.45968688
20MP0003121_genomic_imprinting1.41158027
21MP0001348_abnormal_lacrimal_gland1.33648944
22MP0003123_paternal_imprinting1.32943062
23MP0001485_abnormal_pinna_reflex1.31805162
24MP0001529_abnormal_vocalization1.31301809
25MP0000566_synostosis1.29321391
26MP0004859_abnormal_synaptic_plasticity1.28068338
27MP0005499_abnormal_olfactory_system1.23387604
28MP0005394_taste/olfaction_phenotype1.23387604
29MP0002249_abnormal_larynx_morphology1.20685613
30MP0001905_abnormal_dopamine_level1.19359967
31MP0001963_abnormal_hearing_physiology1.15539227
32MP0001299_abnormal_eye_distance/1.14770791
33MP0001188_hyperpigmentation1.13343283
34MP0004270_analgesia1.10251034
35MP0002282_abnormal_trachea_morphology1.10058673
36MP0002638_abnormal_pupillary_reflex1.10014786
37MP0003635_abnormal_synaptic_transmissio1.09457797
38MP0000026_abnormal_inner_ear1.05360774
39MP0000049_abnormal_middle_ear0.99626424
40MP0005386_behavior/neurological_phenoty0.99299771
41MP0004924_abnormal_behavior0.99299771
42MP0004142_abnormal_muscle_tone0.98411265
43MP0005423_abnormal_somatic_nervous0.96089747
44MP0003880_abnormal_central_pattern0.95979559
45MP0005389_reproductive_system_phenotype0.95838009
46MP0005551_abnormal_eye_electrophysiolog0.95674819
47MP0002234_abnormal_pharynx_morphology0.95255692
48MP0009379_abnormal_foot_pigmentation0.94580484
49MP0000569_abnormal_digit_pigmentation0.90987936
50MP0008789_abnormal_olfactory_epithelium0.88880395
51MP0003787_abnormal_imprinting0.88508450
52MP0003119_abnormal_digestive_system0.87342246
53MP0001968_abnormal_touch/_nociception0.87285636
54MP0001765_abnormal_ion_homeostasis0.85466797
55MP0002572_abnormal_emotion/affect_behav0.85187354
56MP0002063_abnormal_learning/memory/cond0.85005932
57MP0003329_amyloid_beta_deposits0.83363749
58MP0003938_abnormal_ear_development0.82748037
59MP0005253_abnormal_eye_physiology0.81555388
60MP0009745_abnormal_behavioral_response0.80497898
61MP0002272_abnormal_nervous_system0.79307864
62MP0005377_hearing/vestibular/ear_phenot0.77910943
63MP0003878_abnormal_ear_physiology0.77910943
64MP0004811_abnormal_neuron_physiology0.77886126
65MP0002064_seizures0.77073394
66MP0003115_abnormal_respiratory_system0.76598431
67MP0003136_yellow_coat_color0.76095419
68MP0002736_abnormal_nociception_after0.75135370
69MP0000678_abnormal_parathyroid_gland0.74716685
70MP0003011_delayed_dark_adaptation0.73729969
71MP0005647_abnormal_sex_gland0.73391282
72MP0008995_early_reproductive_senescence0.72840272
73MP0002081_perinatal_lethality0.70211934
74MP0001440_abnormal_grooming_behavior0.70039450
75MP0002069_abnormal_eating/drinking_beha0.69910488
76MP0008058_abnormal_DNA_repair0.69237946
77MP0006072_abnormal_retinal_apoptosis0.68767387
78MP0003879_abnormal_hair_cell0.67105084
79MP0000751_myopathy0.65870993
80MP0009053_abnormal_anal_canal0.64446510
81MP0001486_abnormal_startle_reflex0.63902798
82MP0002152_abnormal_brain_morphology0.62695077
83MP0005248_abnormal_Harderian_gland0.62421544
84MP0008569_lethality_at_weaning0.61934044
85MP0002734_abnormal_mechanical_nocicepti0.60230102
86MP0003633_abnormal_nervous_system0.59868245
87MP0000955_abnormal_spinal_cord0.58533262
88MP0001324_abnormal_eye_pigmentation0.56693949
89MP0008057_abnormal_DNA_replication0.56238964
90MP0003861_abnormal_nervous_system0.56191105
91MP0004036_abnormal_muscle_relaxation0.55892501
92MP0002067_abnormal_sensory_capabilities0.55870415
93MP0002557_abnormal_social/conspecific_i0.53679361
94MP0001293_anophthalmia0.53379695
95MP0004145_abnormal_muscle_electrophysio0.52950322
96MP0000534_abnormal_ureter_morphology0.52874133
97MP0002882_abnormal_neuron_morphology0.52867364
98MP0002229_neurodegeneration0.52292895
99MP0005391_vision/eye_phenotype0.52019020
100MP0003950_abnormal_plasma_membrane0.50486090
101MP0002269_muscular_atrophy0.49967196
102MP0000358_abnormal_cell_content/0.49915104
103MP0002909_abnormal_adrenal_gland0.49642203
104MP0003631_nervous_system_phenotype0.49331858
105MP0000778_abnormal_nervous_system0.47728146
106MP0003699_abnormal_female_reproductive0.46403920
107MP0010094_abnormal_chromosome_stability0.43106483
108MP0004133_heterotaxia0.41862288
109MP0002066_abnormal_motor_capabilities/c0.41680356
110MP0001502_abnormal_circadian_rhythm0.41248865
111MP0003283_abnormal_digestive_organ0.41071394
112MP0008961_abnormal_basal_metabolism0.41055304
113MP0004885_abnormal_endolymph0.39563942
114MP0003942_abnormal_urinary_system0.39561948
115MP0005195_abnormal_posterior_eye0.39404842
116MP0002752_abnormal_somatic_nervous0.39127509
117MP0004742_abnormal_vestibular_system0.36899499
118MP0002184_abnormal_innervation0.35951285
119MP0003634_abnormal_glial_cell0.35742578
120MP0002735_abnormal_chemical_nociception0.34850667
121MP0002928_abnormal_bile_duct0.34467503
122MP0005646_abnormal_pituitary_gland0.34350999
123MP0006276_abnormal_autonomic_nervous0.32883561
124MP0005666_abnormal_adipose_tissue0.30547775
125MP0001501_abnormal_sleep_pattern0.28543128
126MP0003786_premature_aging0.28523174
127MP0002822_catalepsy0.28123848
128MP0008007_abnormal_cellular_replicative0.27978854
129MP0004134_abnormal_chest_morphology0.27931391
130MP0002733_abnormal_thermal_nociception0.27922277
131MP0003632_abnormal_nervous_system0.27763516
132MP0000631_abnormal_neuroendocrine_gland0.27290165

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.91209482
2Abnormal respiratory epithelium morphology (HP:0012253)8.46963348
3Abnormal respiratory motile cilium morphology (HP:0005938)8.46963348
4Rhinitis (HP:0012384)7.44228011
5Abnormal ciliary motility (HP:0012262)7.11378374
6Chronic bronchitis (HP:0004469)6.75349576
7Infertility (HP:0000789)6.41428641
8Myokymia (HP:0002411)6.07772243
9Nasal polyposis (HP:0100582)5.73663239
10Abnormality of the nasal mucosa (HP:0000433)4.63447967
11Nephronophthisis (HP:0000090)4.62291718
12Focal motor seizures (HP:0011153)4.27107865
13Bronchiectasis (HP:0002110)4.17771435
14Bronchitis (HP:0012387)4.07158970
15Male infertility (HP:0003251)4.04308286
16Focal seizures (HP:0007359)3.75335180
17Abnormality of the renal medulla (HP:0100957)3.44450341
18Atonic seizures (HP:0010819)3.43370100
19Severe visual impairment (HP:0001141)3.36800132
20Febrile seizures (HP:0002373)3.28329255
21Epileptic encephalopathy (HP:0200134)3.25244434
22Abnormality of the lower motor neuron (HP:0002366)3.21590395
23Abnormal spermatogenesis (HP:0008669)3.09519265
24Recurrent otitis media (HP:0000403)3.03561360
25Action tremor (HP:0002345)2.94309454
26Limb dystonia (HP:0002451)2.88719132
27Chronic hepatic failure (HP:0100626)2.87630974
28Postural instability (HP:0002172)2.86592185
29Recurrent sinusitis (HP:0011108)2.85194633
30Abnormality of midbrain morphology (HP:0002418)2.82349135
31Molar tooth sign on MRI (HP:0002419)2.82349135
32Bony spicule pigmentary retinopathy (HP:0007737)2.81725683
33Tubular atrophy (HP:0000092)2.73782837
34Medial flaring of the eyebrow (HP:0010747)2.73710583
35Tubulointerstitial nephritis (HP:0001970)2.70462232
36Abnormality of the aortic arch (HP:0012303)2.67910373
37Amblyopia (HP:0000646)2.58117497
38Drooling (HP:0002307)2.51112120
39Gonadotropin excess (HP:0000837)2.48730536
40Tubulointerstitial abnormality (HP:0001969)2.47079427
41Renovascular hypertension (HP:0100817)2.46785513
42Optic nerve hypoplasia (HP:0000609)2.46119343
43Abnormality of the corticospinal tract (HP:0002492)2.40868068
44Amyotrophic lateral sclerosis (HP:0007354)2.40370226
45Impulsivity (HP:0100710)2.38637507
46Peripheral hypomyelination (HP:0007182)2.38346269
47Impaired vibration sensation in the lower limbs (HP:0002166)2.36468209
48Recurrent bronchitis (HP:0002837)2.28365232
49Dialeptic seizures (HP:0011146)2.26031231
50Absence seizures (HP:0002121)2.25342016
51Excessive salivation (HP:0003781)2.24993278
52Azoospermia (HP:0000027)2.17353696
53Abnormal gallbladder physiology (HP:0012438)2.14898642
54Cholecystitis (HP:0001082)2.14898642
55Failure to thrive in infancy (HP:0001531)2.11060089
56Tubulointerstitial fibrosis (HP:0005576)2.09198566
57Dyschromatopsia (HP:0007641)2.08318765
58Spastic gait (HP:0002064)2.08303059
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07011599
60Hyperkalemia (HP:0002153)2.06385246
61Postaxial foot polydactyly (HP:0001830)2.05584874
62Polyphagia (HP:0002591)2.04838022
63Generalized tonic-clonic seizures (HP:0002069)2.04315828
64Resting tremor (HP:0002322)2.02706011
65Truncal obesity (HP:0001956)2.00601815
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6384262
67Absent/shortened dynein arms (HP:0200106)12.2235742
68Dynein arm defect of respiratory motile cilia (HP:0012255)12.2235742
69Attenuation of retinal blood vessels (HP:0007843)1.99230276
70Polydipsia (HP:0001959)1.99159262
71Abnormal drinking behavior (HP:0030082)1.99159262
72Abnormal eating behavior (HP:0100738)1.99126978
73Fibular hypoplasia (HP:0003038)1.98939451
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98650950
75Genetic anticipation (HP:0003743)1.98603434
76Stereotypic behavior (HP:0000733)1.96533022
77Abnormal rod and cone electroretinograms (HP:0008323)1.95814017
78Double outlet right ventricle (HP:0001719)1.95659652
79Congenital malformation of the right heart (HP:0011723)1.95659652
80Stage 5 chronic kidney disease (HP:0003774)1.93234346
81Ankle clonus (HP:0011448)1.91437784
82Obsessive-compulsive behavior (HP:0000722)1.89899480
83Turricephaly (HP:0000262)1.89436039
84Torticollis (HP:0000473)1.88505904
85Abnormality of macular pigmentation (HP:0008002)1.88068091
86Fetal akinesia sequence (HP:0001989)1.86262454
87Congenital hepatic fibrosis (HP:0002612)1.85600238
88Urinary bladder sphincter dysfunction (HP:0002839)1.85401920
89Short ribs (HP:0000773)1.84887996
90Hypoplastic ischia (HP:0003175)1.84612190
91Heterotopia (HP:0002282)1.83314659
92Spastic tetraparesis (HP:0001285)1.83176460
93Abnormality of the ischium (HP:0003174)1.82528469
94Dysmetria (HP:0001310)1.80980332
95Supranuclear gaze palsy (HP:0000605)1.80698200
96Choroideremia (HP:0001139)1.80241427
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79556350
98Aplasia/Hypoplasia of the earlobes (HP:0009906)1.79314267
99Decreased central vision (HP:0007663)1.79231907
100Growth hormone deficiency (HP:0000824)1.78967553
101Spastic tetraplegia (HP:0002510)1.78094275
102Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78017260
103Hypoplasia of the brainstem (HP:0002365)1.78017260
104Abnormality of binocular vision (HP:0011514)1.76661221
105Diplopia (HP:0000651)1.76661221
106Oculomotor apraxia (HP:0000657)1.75978091
107Hyperthyroidism (HP:0000836)1.75617004
108Septo-optic dysplasia (HP:0100842)1.75118653
109Omphalocele (HP:0001539)1.73880435
110Absent frontal sinuses (HP:0002688)1.72556078
111Microglossia (HP:0000171)1.72320369
112Abnormality of ocular smooth pursuit (HP:0000617)1.71966132
113Sleep apnea (HP:0010535)1.71675871
114Renal dysplasia (HP:0000110)1.70907594
115Postaxial hand polydactyly (HP:0001162)1.70509407
116Broad-based gait (HP:0002136)1.69286264
117Specific learning disability (HP:0001328)1.68638146
118Hemiparesis (HP:0001269)1.68568528
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67876785
120Short 4th metacarpal (HP:0010044)1.67876785
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67214996
122Impaired proprioception (HP:0010831)1.66811774
123Bowel incontinence (HP:0002607)1.66378323
124Status epilepticus (HP:0002133)1.65397485
125Abnormality of dentin (HP:0010299)1.64570647
126Bradykinesia (HP:0002067)1.64566997
127Vaginal atresia (HP:0000148)1.64532311
128Epileptiform EEG discharges (HP:0011182)1.63848455
129Potter facies (HP:0002009)1.63129671
130Facial shape deformation (HP:0011334)1.63129671
131Poor coordination (HP:0002370)1.61718133
132Bell-shaped thorax (HP:0001591)1.60708207
133Gait imbalance (HP:0002141)1.60227961
134Taurodontia (HP:0000679)1.59848726
135Abnormality of permanent molar morphology (HP:0011071)1.59848726
136Abnormality of the dental root (HP:0006486)1.59848726
137Visual hallucinations (HP:0002367)1.59098118
138Abnormality of the labia minora (HP:0012880)1.59096929
139Abnormality of renal excretion (HP:0011036)1.58501562
140Abnormality of the diencephalon (HP:0010662)1.57500226
141Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56997501
142Intellectual disability, moderate (HP:0002342)1.56899332
143Annular pancreas (HP:0001734)1.56790077
144Abnormality of the renal cortex (HP:0011035)1.56683533
145Facial cleft (HP:0002006)1.56575724
146Congenital primary aphakia (HP:0007707)1.55240974
147J-shaped sella turcica (HP:0002680)1.54316813
148Progressive cerebellar ataxia (HP:0002073)1.52349458
149Aplasia/Hypoplasia of the lens (HP:0008063)1.49863100
150Gaze-evoked nystagmus (HP:0000640)1.49487129
151Abnormality of molar morphology (HP:0011070)1.48009428
152Abnormality of molar (HP:0011077)1.48009428
153Abnormality of saccadic eye movements (HP:0000570)1.47416557
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.47357447
155Broad distal phalanx of finger (HP:0009836)1.45545582
156Abnormality of the dental pulp (HP:0006479)1.45465427
157Neurofibrillary tangles (HP:0002185)1.44893093
158Absent epiphyses (HP:0010577)1.42187844
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.42187844
160Cystic liver disease (HP:0006706)1.40946986
161Pancreatic fibrosis (HP:0100732)1.40037901
162Short thorax (HP:0010306)1.40001829
163Median cleft lip (HP:0000161)1.38705992
164Deformed sella turcica (HP:0002681)1.38671966
165Supernumerary spleens (HP:0009799)1.36446583
166Bundle branch block (HP:0011710)1.35979411
167Upper motor neuron abnormality (HP:0002127)1.35719201
168Abnormal urine output (HP:0012590)1.34627364
169Pachygyria (HP:0001302)1.31060718
170Nephrogenic diabetes insipidus (HP:0009806)1.30306666
171Abnormal biliary tract physiology (HP:0012439)1.29878683
172Bile duct proliferation (HP:0001408)1.29878683
173Decreased motor nerve conduction velocity (HP:0003431)1.29738784
174Cerebellar dysplasia (HP:0007033)1.29421143
175Genital tract atresia (HP:0001827)1.27862840
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.27548663
177Decreased electroretinogram (ERG) amplitude (HP:0000654)1.27498781
178Cerebral inclusion bodies (HP:0100314)1.27136370
179Aplasia/Hypoplasia of the fibula (HP:0006492)1.25202641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.77290084
2PDK47.77290084
3TESK15.91796958
4PRKD35.25554038
5PDK24.94987002
6ICK4.16581349
7CASK2.94150129
8PNCK2.64137041
9PTK2B2.60740991
10WNK42.25491671
11STK382.20897340
12PLK22.12267099
13STK392.11894979
14SIK21.87719176
15DDR21.79497896
16TNIK1.71412131
17NEK21.64119210
18DYRK21.59072600
19MAP4K21.57137084
20MAPK131.53544256
21CDK191.39099776
22SGK2231.39068138
23SGK4941.39068138
24TYRO31.26483455
25BRD41.18880726
26DYRK1B1.18426678
27WNK11.16342152
28CAMK1D1.12431506
29KSR21.11452719
30PDK11.07398716
31DYRK1A1.02447394
32ARAF1.00870858
33INSRR0.98744081
34SGK20.93179200
35AKT30.86544988
36NTRK20.86031968
37MAP3K40.83265202
38CAMK1G0.82462655
39PINK10.78037310
40CCNB10.75964033
41MAPK150.75485455
42PRKCH0.75252068
43SGK10.73442490
44LMTK20.72292140
45RPS6KA20.70306415
46PKN10.66716378
47PAK30.63646760
48NTRK30.63008357
49PDPK10.60249609
50PASK0.60186918
51EPHB20.59147273
52CAMKK10.59139053
53PAK60.57599278
54CAMK40.56324031
55DYRK30.54007812
56KSR10.53694144
57SGK30.53647717
58STK30.53308200
59EEF2K0.52757415
60MAP2K70.52692866
61PRKCG0.52654981
62TTK0.52364194
63MARK10.51105165
64BMPR1B0.50020076
65CSNK1G20.49747435
66FGFR20.49424863
67CHEK20.49097340
68MKNK20.48728612
69MINK10.47010417
70RIPK40.45631758
71CDC70.45486225
72CAMK2B0.45141099
73MAP3K90.42788826
74CHEK10.41986855
75ROCK10.40451709
76MAP2K60.39817716
77CDK30.38804397
78STK38L0.37013256
79IRAK10.35093665
80DMPK0.34063391
81NEK60.33145370
82MAPK140.32988168
83MUSK0.32615087
84MTOR0.31579898
85MARK20.31137826
86PAK10.30643957
87ATM0.30544918
88ATR0.29430444
89IRAK20.29315830
90TESK20.28935526
91MAP2K40.28413854
92EPHA40.28247300
93PAK20.27587836
94PRKAA10.27347454
95CDK150.26815548
96RPS6KB10.25204019
97CDK180.24597088
98STK110.23831908
99WEE10.23038564
100CDK11A0.21654948
101CAMK2A0.20635088
102PRKCZ0.20358087
103CDK140.19857006
104CDK50.17828482
105RIPK10.16902769
106WNK30.16087950
107BRSK10.16045087
108GSK3B0.15556827
109DAPK20.13821236
110MAPKAPK50.13503133
111TAOK10.12083968
112NTRK10.11895314
113MAPK80.11878015
114PLK10.11150332
115RPS6KA30.10871868
116CSNK1D0.10430356
117CDK120.10386654
118GRK50.10201115
119MAPK100.09873098
120CDK10.09586786
121LATS20.09215639
122PRKCB0.08412194
123CAMK10.08331870
124CDK20.07997714
125PHKG10.07982127
126PHKG20.07982127
127PRKG10.07424619
128PRKDC0.07064026
129BRAF0.06155759
130PAK40.05816395
131UHMK10.05391832
132CDC42BPA0.04984567
133PRKACB0.04659567
134PRKACG0.04601151
135CSNK1E0.03932891
136RPS6KA10.03839106
137PLK40.03823457

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.62279700
2Fatty acid biosynthesis_Homo sapiens_hsa000613.60599893
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.12681178
4Pyruvate metabolism_Homo sapiens_hsa006203.09965934
5Vitamin B6 metabolism_Homo sapiens_hsa007503.07963710
6Glucagon signaling pathway_Homo sapiens_hsa049222.64596918
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.46885007
8Amphetamine addiction_Homo sapiens_hsa050312.35112927
9Dorso-ventral axis formation_Homo sapiens_hsa043202.15597198
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11707944
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10960126
12Oocyte meiosis_Homo sapiens_hsa041142.08955892
13Propanoate metabolism_Homo sapiens_hsa006402.04895922
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.01915985
15Linoleic acid metabolism_Homo sapiens_hsa005911.98301631
16Synaptic vesicle cycle_Homo sapiens_hsa047211.91386211
17Basal transcription factors_Homo sapiens_hsa030221.90724926
18Long-term potentiation_Homo sapiens_hsa047201.78537884
19Cardiac muscle contraction_Homo sapiens_hsa042601.71285683
20Renin secretion_Homo sapiens_hsa049241.67078975
21Glycerolipid metabolism_Homo sapiens_hsa005611.64358995
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53615145
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50568726
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46197325
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.45916551
26Insulin secretion_Homo sapiens_hsa049111.44347323
27Pentose phosphate pathway_Homo sapiens_hsa000301.43548223
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43539677
29Selenocompound metabolism_Homo sapiens_hsa004501.39579128
30Nicotine addiction_Homo sapiens_hsa050331.38965370
31Circadian entrainment_Homo sapiens_hsa047131.36672506
32Fructose and mannose metabolism_Homo sapiens_hsa000511.36530584
33Huntingtons disease_Homo sapiens_hsa050161.33642702
34Long-term depression_Homo sapiens_hsa047301.29248506
35Fanconi anemia pathway_Homo sapiens_hsa034601.28724989
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26454168
37mRNA surveillance pathway_Homo sapiens_hsa030151.25868700
38Serotonergic synapse_Homo sapiens_hsa047261.22881435
39Estrogen signaling pathway_Homo sapiens_hsa049151.18809943
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14286846
41Salivary secretion_Homo sapiens_hsa049701.13578821
42Gap junction_Homo sapiens_hsa045401.13339929
43PPAR signaling pathway_Homo sapiens_hsa033201.13123003
44Taste transduction_Homo sapiens_hsa047421.12937304
45Collecting duct acid secretion_Homo sapiens_hsa049661.12693962
46Glutamatergic synapse_Homo sapiens_hsa047241.12254002
47Olfactory transduction_Homo sapiens_hsa047401.08992886
48Calcium signaling pathway_Homo sapiens_hsa040201.08657394
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04011433
50Mineral absorption_Homo sapiens_hsa049781.02910129
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02808094
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01149724
53Gastric acid secretion_Homo sapiens_hsa049710.99432149
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.99082960
55Carbon metabolism_Homo sapiens_hsa012000.98750420
56Hedgehog signaling pathway_Homo sapiens_hsa043400.97603423
57Butanoate metabolism_Homo sapiens_hsa006500.97587747
58Dopaminergic synapse_Homo sapiens_hsa047280.94947692
59Ether lipid metabolism_Homo sapiens_hsa005650.94020815
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92771491
61ErbB signaling pathway_Homo sapiens_hsa040120.90458495
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89077679
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.88420685
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85686834
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.85393590
66Cocaine addiction_Homo sapiens_hsa050300.85216513
67Thyroid hormone synthesis_Homo sapiens_hsa049180.82110489
68Morphine addiction_Homo sapiens_hsa050320.81091972
69Hippo signaling pathway_Homo sapiens_hsa043900.80094480
70Fat digestion and absorption_Homo sapiens_hsa049750.78635172
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77236697
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76416166
73Fatty acid metabolism_Homo sapiens_hsa012120.76345388
74Glioma_Homo sapiens_hsa052140.75030949
75cAMP signaling pathway_Homo sapiens_hsa040240.74645451
76RNA transport_Homo sapiens_hsa030130.73817506
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.72993292
78Dilated cardiomyopathy_Homo sapiens_hsa054140.69504279
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.66408633
80Oxytocin signaling pathway_Homo sapiens_hsa049210.66322964
81Biosynthesis of amino acids_Homo sapiens_hsa012300.65417453
82Purine metabolism_Homo sapiens_hsa002300.64867687
83GnRH signaling pathway_Homo sapiens_hsa049120.64083194
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63491926
85Phototransduction_Homo sapiens_hsa047440.63222539
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62809065
87Inositol phosphate metabolism_Homo sapiens_hsa005620.61553926
88Pancreatic secretion_Homo sapiens_hsa049720.60503379
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.60059252
90Bile secretion_Homo sapiens_hsa049760.59937786
91GABAergic synapse_Homo sapiens_hsa047270.59674477
92Endocytosis_Homo sapiens_hsa041440.59577347
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59075745
94Alcoholism_Homo sapiens_hsa050340.59055785
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58776559
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58358281
97VEGF signaling pathway_Homo sapiens_hsa043700.58203983
98Type II diabetes mellitus_Homo sapiens_hsa049300.57409118
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56948041
100AMPK signaling pathway_Homo sapiens_hsa041520.56825555
101Tight junction_Homo sapiens_hsa045300.56652450
102Rap1 signaling pathway_Homo sapiens_hsa040150.56478095
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56334609
104Choline metabolism in cancer_Homo sapiens_hsa052310.51951221
105Ras signaling pathway_Homo sapiens_hsa040140.51781193
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49719207
107Antigen processing and presentation_Homo sapiens_hsa046120.48267119
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47236659
109Wnt signaling pathway_Homo sapiens_hsa043100.46803254
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43671093
111Arginine and proline metabolism_Homo sapiens_hsa003300.43310285
112Notch signaling pathway_Homo sapiens_hsa043300.42673188
113Fatty acid degradation_Homo sapiens_hsa000710.41491192
114Endometrial cancer_Homo sapiens_hsa052130.39549704
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.38468242
116Cholinergic synapse_Homo sapiens_hsa047250.35322732
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34506224
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34361572
119ABC transporters_Homo sapiens_hsa020100.33273693
120mTOR signaling pathway_Homo sapiens_hsa041500.30465256
121Renin-angiotensin system_Homo sapiens_hsa046140.30430162
122Axon guidance_Homo sapiens_hsa043600.29239289
123Basal cell carcinoma_Homo sapiens_hsa052170.28987681
124Alzheimers disease_Homo sapiens_hsa050100.28777162
125Melanogenesis_Homo sapiens_hsa049160.27587014
126Protein digestion and absorption_Homo sapiens_hsa049740.27487322
127Colorectal cancer_Homo sapiens_hsa052100.27381658
128Insulin signaling pathway_Homo sapiens_hsa049100.27080841
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26206557
130MAPK signaling pathway_Homo sapiens_hsa040100.25517956
131Adherens junction_Homo sapiens_hsa045200.25291504
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25012076

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