CCDC137

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.06380850
2DNA deamination (GO:0045006)7.53051651
3transcription from mitochondrial promoter (GO:0006390)7.16695339
4replication fork processing (GO:0031297)6.47817541
5proline metabolic process (GO:0006560)6.08152626
6embryonic process involved in female pregnancy (GO:0060136)5.82690933
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.78583327
8DNA strand renaturation (GO:0000733)5.24265281
9poly(A)+ mRNA export from nucleus (GO:0016973)5.23462652
10oxidative demethylation (GO:0070989)5.08324102
11viral mRNA export from host cell nucleus (GO:0046784)4.98499104
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.80085374
13somatic hypermutation of immunoglobulin genes (GO:0016446)4.80085374
14DNA unwinding involved in DNA replication (GO:0006268)4.68175735
15telomere maintenance via semi-conservative replication (GO:0032201)4.65700507
16positive regulation of protein homooligomerization (GO:0032464)4.65524998
17mitochondrial DNA metabolic process (GO:0032042)4.64133711
18DNA integration (GO:0015074)4.62620829
19ribosomal small subunit biogenesis (GO:0042274)4.50377410
20formation of translation preinitiation complex (GO:0001731)4.48110423
21mitochondrial RNA metabolic process (GO:0000959)4.28519840
22regulation of double-strand break repair via homologous recombination (GO:0010569)4.27954066
23maturation of 5.8S rRNA (GO:0000460)4.20749127
24negative regulation of cell cycle arrest (GO:0071157)4.18428555
25establishment of apical/basal cell polarity (GO:0035089)4.16360452
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.11309065
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.08081577
28base-excision repair (GO:0006284)4.06603288
29mitotic chromosome condensation (GO:0007076)4.05815180
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.01635106
31regulation of integrin activation (GO:0033623)4.01217219
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.97980072
33DNA ligation (GO:0006266)3.97002499
34DNA strand elongation involved in DNA replication (GO:0006271)3.94016483
35face development (GO:0060324)3.93047919
36establishment of integrated proviral latency (GO:0075713)3.86964225
37mitotic metaphase plate congression (GO:0007080)3.82175118
38DNA strand elongation (GO:0022616)3.82148849
39pseudouridine synthesis (GO:0001522)3.81480064
40kinetochore assembly (GO:0051382)3.81049020
41regulation of protein homooligomerization (GO:0032462)3.80461423
42base-excision repair, AP site formation (GO:0006285)3.79794361
43telomere maintenance via recombination (GO:0000722)3.79467737
44regulation of mitochondrial translation (GO:0070129)3.74944334
45negative regulation of mRNA processing (GO:0050686)3.74939120
46termination of RNA polymerase II transcription (GO:0006369)3.74819366
47mRNA cleavage (GO:0006379)3.68528973
48peptidyl-arginine omega-N-methylation (GO:0035247)3.66976793
49ribosome assembly (GO:0042255)3.66615133
50establishment of monopolar cell polarity (GO:0061162)3.63939709
51establishment or maintenance of monopolar cell polarity (GO:0061339)3.63939709
52GDP-mannose metabolic process (GO:0019673)3.60645738
53meiotic chromosome segregation (GO:0045132)3.60353849
54DNA replication initiation (GO:0006270)3.60078092
55mitotic sister chromatid segregation (GO:0000070)3.58566964
56mitotic G1 DNA damage checkpoint (GO:0031571)3.58512115
57histone H4-K12 acetylation (GO:0043983)3.57833635
58double-strand break repair via nonhomologous end joining (GO:0006303)3.53671251
59non-recombinational repair (GO:0000726)3.53671251
60regulation of translational termination (GO:0006449)3.52837711
61nucleobase-containing small molecule interconversion (GO:0015949)3.50575401
62positive regulation of developmental pigmentation (GO:0048087)3.49821870
63positive regulation of DNA repair (GO:0045739)3.48601247
64telomere maintenance via telomere lengthening (GO:0010833)3.48439408
65ribosome biogenesis (GO:0042254)3.47625102
66DNA double-strand break processing (GO:0000729)3.47539728
67negative regulation of RNA splicing (GO:0033119)3.44581722
68DNA replication checkpoint (GO:0000076)3.44411108
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44075493
70dosage compensation (GO:0007549)3.43553213
71negative regulation of JAK-STAT cascade (GO:0046426)3.43199251
72proteasome assembly (GO:0043248)3.42724460
73cellular response to ATP (GO:0071318)3.41076009
74ribosomal large subunit biogenesis (GO:0042273)3.38866361
75spliceosomal tri-snRNP complex assembly (GO:0000244)3.37370821
76pyrimidine nucleotide catabolic process (GO:0006244)3.37257827
77embryonic camera-type eye development (GO:0031076)3.35908922
78establishment of viral latency (GO:0019043)3.35429201
79ribosomal small subunit assembly (GO:0000028)3.33982680
80histone arginine methylation (GO:0034969)3.30082196
81G1 DNA damage checkpoint (GO:0044783)3.29874216
82rRNA processing (GO:0006364)3.28988766
83DNA topological change (GO:0006265)3.27918698
84negative regulation of ligase activity (GO:0051352)3.26994411
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26994411
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24769415
87kinetochore organization (GO:0051383)3.24515856
88regulation of double-strand break repair (GO:2000779)3.23991838
89spliceosomal snRNP assembly (GO:0000387)3.21623860
90mitotic recombination (GO:0006312)3.21618625
91protein localization to chromosome, centromeric region (GO:0071459)3.21240077
92mitochondrial DNA replication (GO:0006264)3.20038108
93mitotic nuclear envelope reassembly (GO:0007084)3.19519811
94nuclear envelope reassembly (GO:0031468)3.19519811
95tRNA methylation (GO:0030488)3.18915174
96rRNA metabolic process (GO:0016072)3.18500484
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18017735
98protein maturation by protein folding (GO:0022417)3.17434675
99positive regulation by host of viral transcription (GO:0043923)3.14913690
100rRNA modification (GO:0000154)3.11941621
101positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09687046
102mitotic G1/S transition checkpoint (GO:0044819)3.08881763
103rRNA transcription (GO:0009303)3.07005552
104single strand break repair (GO:0000012)3.06919836
105protein complex localization (GO:0031503)3.06563055
106viral transcription (GO:0019083)3.05885889
107sister chromatid segregation (GO:0000819)3.04769216
108ribonucleoprotein complex biogenesis (GO:0022613)3.00645441
109regulation of mammary gland epithelial cell proliferation (GO:0033599)3.00489629
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99808835
111negative regulation of Ras GTPase activity (GO:0034261)2.98989394
112protein localization to kinetochore (GO:0034501)2.98603922
113transcription-coupled nucleotide-excision repair (GO:0006283)2.97752190
114folic acid-containing compound biosynthetic process (GO:0009396)2.97281351
115cellular response to zinc ion (GO:0071294)2.96749840
116DNA-templated transcription, termination (GO:0006353)2.96436951
117mRNA polyadenylation (GO:0006378)2.96420361
118regulation of translational fidelity (GO:0006450)2.94784154
119translational termination (GO:0006415)2.94066210
120mitotic nuclear envelope disassembly (GO:0007077)2.93772471
121DNA demethylation (GO:0080111)2.93762188
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91948351
123peptidyl-arginine N-methylation (GO:0035246)2.91327446
124peptidyl-arginine methylation (GO:0018216)2.91327446
125tRNA modification (GO:0006400)2.90559012
126mRNA export from nucleus (GO:0006406)2.90482036
127embryonic placenta development (GO:0001892)2.90243138
128RNA polyadenylation (GO:0043631)2.87715949
129maturation of SSU-rRNA (GO:0030490)2.86389607
130ncRNA 3-end processing (GO:0043628)2.86352777
131cellular component biogenesis (GO:0044085)2.85778248
132negative regulation of mRNA metabolic process (GO:1903312)2.85456462
133resolution of meiotic recombination intermediates (GO:0000712)2.85206732
134regulation of DNA damage checkpoint (GO:2000001)2.85000965
135regulation of DNA repair (GO:0006282)2.84504162
136Golgi transport vesicle coating (GO:0048200)2.84078117
137COPI coating of Golgi vesicle (GO:0048205)2.84078117
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83832886
139mRNA splicing, via spliceosome (GO:0000398)2.83832886
140somatic cell DNA recombination (GO:0016444)2.83793998
141somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.83793998
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83591218
143heterochromatin organization (GO:0070828)2.83233851
144nucleobase biosynthetic process (GO:0046112)2.81591604
145translational elongation (GO:0006414)2.80122519
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79012097
147translational initiation (GO:0006413)2.78665465
148metaphase plate congression (GO:0051310)2.78358121
149pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77514464
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76576549
151pentose-phosphate shunt (GO:0006098)2.76555057
152RNA splicing, via transesterification reactions (GO:0000375)2.76534541
153trophectodermal cell differentiation (GO:0001829)2.76441868
154signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76357917
155signal transduction involved in DNA damage checkpoint (GO:0072422)2.76357917
156regulation of cellular amino acid metabolic process (GO:0006521)2.75717326
157mRNA 3-end processing (GO:0031124)2.75572953
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74796116
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74796116
160regulation of RNA export from nucleus (GO:0046831)2.74398274
161convergent extension (GO:0060026)2.74104857
162RNA export from nucleus (GO:0006405)2.74031895
163translation (GO:0006412)2.73580241
164DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73579924
165signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72770986
166signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72770986
167signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72770986
168pentose metabolic process (GO:0019321)2.72487469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06002654
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.31883495
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17334082
4MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09701535
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98148709
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93602103
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76302898
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.74375404
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46507833
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.44929558
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.28823876
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27512298
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22964673
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18987971
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18987971
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18987971
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15712164
18VDR_21846776_ChIP-Seq_THP-1_Human2.14443884
19* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06953952
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.06074460
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.04797391
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02459256
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00989033
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96450332
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96160306
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95423559
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.94716086
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.93915964
29DCP1A_22483619_ChIP-Seq_HELA_Human1.88885623
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87493932
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86341927
32TTF2_22483619_ChIP-Seq_HELA_Human1.85787049
33GABP_19822575_ChIP-Seq_HepG2_Human1.82068634
34VDR_23849224_ChIP-Seq_CD4+_Human1.81516033
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81406913
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81338917
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80716181
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.79929065
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78307195
40XRN2_22483619_ChIP-Seq_HELA_Human1.78283447
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71601434
42ZNF263_19887448_ChIP-Seq_K562_Human1.69769254
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67220862
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65438071
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64576867
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60700758
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58600382
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57231635
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56623293
50PU.1_20513432_ChIP-Seq_Bcells_Mouse1.56488070
51CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.55918106
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55685218
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54363761
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.53589337
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50975772
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.47593054
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46128629
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45959232
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44348853
60POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43656241
61AR_21909140_ChIP-Seq_LNCAP_Human1.43405670
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43049964
63FOXP3_21729870_ChIP-Seq_TREG_Human1.42818516
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41744183
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41515421
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40158297
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.38588530
68* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38349431
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35423768
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34508932
71MYC_22102868_ChIP-Seq_BL_Human1.34487669
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.34464032
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34202545
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33916307
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33061563
76KDM5A_27292631_Chip-Seq_BREAST_Human1.32176657
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31429836
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29956863
79LXR_22292898_ChIP-Seq_THP-1_Human1.28494807
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28275327
81CIITA_25753668_ChIP-Seq_RAJI_Human1.27182688
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.26012175
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23853227
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.23810118
85TFEB_21752829_ChIP-Seq_HELA_Human1.23489628
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22675670
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22532976
88POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22447797
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.20916665
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20515535
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20184752
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20174685
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19599158
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17502325
95RACK7_27058665_Chip-Seq_MCF-7_Human1.17462807
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17279793
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14828479
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.14766842
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13918576
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13672297
101* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12809121
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11823562
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11741528
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11693088
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11670378
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11550293
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11430544
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11360613
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10576179
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10281496
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08553356
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08480650
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06601867
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.03972330
115ETS1_21867929_ChIP-Seq_TH2_Mouse1.03433965
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02920984
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02906166
118SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02056711
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01491695
120IRF1_19129219_ChIP-ChIP_H3396_Human1.01093672
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99473461
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.99469308
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99364031
124MAF_26560356_Chip-Seq_TH2_Human0.98040047
125YY1_22570637_ChIP-Seq_MALME-3M_Human0.97623340
126CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97575044
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97415160
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97154289
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97108075
130P68_20966046_ChIP-Seq_HELA_Human0.96602733
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96508802
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96471243
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95977007
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95344833
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94824711
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94489306
137TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94097160
138TP63_17297297_ChIP-ChIP_HaCaT_Human0.94037913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.71245299
2MP0005171_absent_coat_pigmentation3.84509930
3MP0010094_abnormal_chromosome_stability3.31657555
4MP0003806_abnormal_nucleotide_metabolis3.30530845
5MP0010030_abnormal_orbit_morphology3.28590073
6MP0009278_abnormal_bone_marrow3.16711163
7MP0008058_abnormal_DNA_repair2.86448933
8MP0003693_abnormal_embryo_hatching2.86304828
9MP0002009_preneoplasia2.80833699
10MP0008995_early_reproductive_senescence2.73010586
11MP0003111_abnormal_nucleus_morphology2.65951646
12MP0003786_premature_aging2.51634023
13MP0005174_abnormal_tail_pigmentation2.45138489
14MP0005451_abnormal_body_composition2.44191556
15MP0002877_abnormal_melanocyte_morpholog2.42758120
16MP0004957_abnormal_blastocyst_morpholog2.34361491
17MP0000015_abnormal_ear_pigmentation2.21345685
18MP0005075_abnormal_melanosome_morpholog2.07950062
19MP0008932_abnormal_embryonic_tissue2.04968671
20MP0002249_abnormal_larynx_morphology2.01080048
21MP0008260_abnormal_autophagy2.00746125
22MP0003077_abnormal_cell_cycle1.98358083
23MP0001545_abnormal_hematopoietic_system1.96447686
24MP0005397_hematopoietic_system_phenotyp1.96447686
25MP0003705_abnormal_hypodermis_morpholog1.96323786
26MP0005058_abnormal_lysosome_morphology1.95944519
27MP0000490_abnormal_crypts_of1.94214704
28MP0003283_abnormal_digestive_organ1.83801625
29MP0001293_anophthalmia1.78882336
30MP0005501_abnormal_skin_physiology1.78586728
31MP0004133_heterotaxia1.71706429
32MP0006292_abnormal_olfactory_placode1.71437715
33MP0003890_abnormal_embryonic-extraembry1.66391928
34MP0002796_impaired_skin_barrier1.64755072
35MP0002396_abnormal_hematopoietic_system1.64368920
36MP0010234_abnormal_vibrissa_follicle1.63984612
37MP0006072_abnormal_retinal_apoptosis1.59215908
38MP0001849_ear_inflammation1.54897239
39MP0003941_abnormal_skin_development1.50445256
40MP0004233_abnormal_muscle_weight1.47273779
41MP0008877_abnormal_DNA_methylation1.42517708
42MP0006035_abnormal_mitochondrial_morpho1.42076660
43MP0004185_abnormal_adipocyte_glucose1.41584626
44MP0010307_abnormal_tumor_latency1.40916326
45MP0003136_yellow_coat_color1.40903994
46MP0003119_abnormal_digestive_system1.40263537
47MP0008007_abnormal_cellular_replicative1.34791286
48MP0009840_abnormal_foam_cell1.31070498
49MP0002085_abnormal_embryonic_tissue1.30660563
50MP0000358_abnormal_cell_content/1.30019821
51MP0002084_abnormal_developmental_patter1.28344512
52MP0003567_abnormal_fetal_cardiomyocyte1.28316079
53MP0000470_abnormal_stomach_morphology1.28265987
54MP0001697_abnormal_embryo_size1.27660584
55MP0002282_abnormal_trachea_morphology1.26415999
56MP0002254_reproductive_system_inflammat1.25411068
57MP0009672_abnormal_birth_weight1.24013680
58MP0000858_altered_metastatic_potential1.24007212
59MP0003718_maternal_effect1.23973757
60MP0009333_abnormal_splenocyte_physiolog1.22893630
61MP0000537_abnormal_urethra_morphology1.21310203
62MP0002086_abnormal_extraembryonic_tissu1.21225353
63MP0000462_abnormal_digestive_system1.21035286
64MP0006036_abnormal_mitochondrial_physio1.20647777
65MP0005257_abnormal_intraocular_pressure1.19252755
66MP0003186_abnormal_redox_activity1.18191973
67MP0004858_abnormal_nervous_system1.17935157
68MP0003315_abnormal_perineum_morphology1.16181223
69MP0004197_abnormal_fetal_growth/weight/1.15539229
70MP0000350_abnormal_cell_proliferation1.15347867
71MP0005380_embryogenesis_phenotype1.14930716
72MP0001672_abnormal_embryogenesis/_devel1.14930716
73MP0003763_abnormal_thymus_physiology1.14334070
74MP0009379_abnormal_foot_pigmentation1.13943745
75MP0002932_abnormal_joint_morphology1.11447373
76MP0002075_abnormal_coat/hair_pigmentati1.09141933
77MP0001853_heart_inflammation1.08790362
78MP0002751_abnormal_autonomic_nervous1.08739611
79MP0002111_abnormal_tail_morphology1.08710223
80MP0000579_abnormal_nail_morphology1.06811818
81MP0001186_pigmentation_phenotype1.04755773
82MP0005645_abnormal_hypothalamus_physiol1.04382952
83MP0000371_diluted_coat_color1.03096910
84MP0002114_abnormal_axial_skeleton1.02939311
85MP0002132_abnormal_respiratory_system1.01274093
86MP0001188_hyperpigmentation1.00477166
87MP0005621_abnormal_cell_physiology1.00110208
88MP0002938_white_spotting1.00076501
89MP0002019_abnormal_tumor_incidence0.99277942
90MP0005384_cellular_phenotype0.97264097
91MP0001730_embryonic_growth_arrest0.96330946
92MP0000678_abnormal_parathyroid_gland0.95885160
93MP0003755_abnormal_palate_morphology0.92697715
94MP0000049_abnormal_middle_ear0.92681251
95MP0001873_stomach_inflammation0.92591928
96MP0000313_abnormal_cell_death0.92144884
97MP0001346_abnormal_lacrimal_gland0.92061625
98MP0001216_abnormal_epidermal_layer0.92015266
99MP0002080_prenatal_lethality0.91614548
100MP0000762_abnormal_tongue_morphology0.91010515
101MP0001881_abnormal_mammary_gland0.89228966
102MP0003828_pulmonary_edema0.89060496
103MP0003566_abnormal_cell_adhesion0.87503053
104MP0004808_abnormal_hematopoietic_stem0.86598479
105MP0001340_abnormal_eyelid_morphology0.86164092
106MP0003453_abnormal_keratinocyte_physiol0.85501476
107MP0003935_abnormal_craniofacial_develop0.85466601
108MP0003436_decreased_susceptibility_to0.85344092
109MP0000432_abnormal_head_morphology0.83826238
110MP0002095_abnormal_skin_pigmentation0.83524932
111MP0002405_respiratory_system_inflammati0.82303147
112MP0002722_abnormal_immune_system0.82279774
113MP0005508_abnormal_skeleton_morphology0.82139839
114MP0002116_abnormal_craniofacial_bone0.81690244
115MP0003385_abnormal_body_wall0.80335170
116MP0003984_embryonic_growth_retardation0.79343473
117MP0000685_abnormal_immune_system0.79319709
118MP0001145_abnormal_male_reproductive0.79145559
119MP0003221_abnormal_cardiomyocyte_apopto0.79143293
120MP0002398_abnormal_bone_marrow0.77596136
121MP0002653_abnormal_ependyma_morphology0.77329752
122MP0005389_reproductive_system_phenotype0.76420912
123MP0010352_gastrointestinal_tract_polyps0.75936301
124MP0002429_abnormal_blood_cell0.75770399
125MP0002088_abnormal_embryonic_growth/wei0.75725574
126MP0005076_abnormal_cell_differentiation0.73749227
127MP0002060_abnormal_skin_morphology0.73220003
128MP0003942_abnormal_urinary_system0.73164957
129MP0009931_abnormal_skin_appearance0.73089349
130MP0000689_abnormal_spleen_morphology0.72718054
131MP0002102_abnormal_ear_morphology0.72534237
132MP0001119_abnormal_female_reproductive0.72475507
133MP0000703_abnormal_thymus_morphology0.72402973
134MP0002210_abnormal_sex_determination0.72191164
135MP0003936_abnormal_reproductive_system0.72124645
136MP0002098_abnormal_vibrissa_morphology0.70585553
137MP0003938_abnormal_ear_development0.69132692
138MP0005408_hypopigmentation0.68921604
139MP0003123_paternal_imprinting0.68367383
140MP0001348_abnormal_lacrimal_gland0.67554260
141MP0005391_vision/eye_phenotype0.67462606
142MP0000477_abnormal_intestine_morphology0.66991791
143MP0002160_abnormal_reproductive_system0.66250427
144MP0002089_abnormal_postnatal_growth/wei0.65856580
145MP0000681_abnormal_thyroid_gland0.65769625
146MP0001919_abnormal_reproductive_system0.65107567
147MP0001727_abnormal_embryo_implantation0.65050533
148MP0005623_abnormal_meninges_morphology0.64351555
149MP0000627_abnormal_mammary_gland0.64328464
150MP0004947_skin_inflammation0.64102101
151MP0002163_abnormal_gland_morphology0.62845428
152MP0001661_extended_life_span0.57119013
153MP0000003_abnormal_adipose_tissue0.56958244
154MP0002148_abnormal_hypersensitivity_rea0.55941442
155MP0010771_integument_phenotype0.55441598
156MP0003172_abnormal_lysosome_physiology0.55310131

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.82870087
2Rib fusion (HP:0000902)4.75592217
3Pustule (HP:0200039)4.29541099
4Poikiloderma (HP:0001029)4.24620246
5Facial hemangioma (HP:0000329)4.17306636
6Rectovaginal fistula (HP:0000143)4.13235535
7Rectal fistula (HP:0100590)4.13235535
8Increased IgM level (HP:0003496)3.89318463
9Intestinal fistula (HP:0100819)3.82605851
10Multiple enchondromatosis (HP:0005701)3.72879540
11Annular pancreas (HP:0001734)3.57799920
12Microvesicular hepatic steatosis (HP:0001414)3.55653818
13Progressive muscle weakness (HP:0003323)3.55548429
14Vaginal fistula (HP:0004320)3.54875803
15Absent radius (HP:0003974)3.49667172
16Intestinal atresia (HP:0011100)3.46711882
17Absent thumb (HP:0009777)3.45498561
18Alopecia of scalp (HP:0002293)3.43686513
19Patellar aplasia (HP:0006443)3.32546939
20Tongue fasciculations (HP:0001308)3.30159586
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.27246816
22Aplasia involving forearm bones (HP:0009822)3.26376549
23Absent forearm bone (HP:0003953)3.26376549
24Rough bone trabeculation (HP:0100670)3.22885572
25Abnormality of male internal genitalia (HP:0000022)3.22335380
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22186023
27Trismus (HP:0000211)3.19926115
28Squamous cell carcinoma (HP:0002860)3.19878372
29Aplasia/hypoplasia of the humerus (HP:0006507)3.13718673
30Premature graying of hair (HP:0002216)3.08863870
31Aplasia/Hypoplasia of the patella (HP:0006498)3.05595194
32Short humerus (HP:0005792)3.04801340
33Cholecystitis (HP:0001082)3.02699905
34Abnormal gallbladder physiology (HP:0012438)3.02699905
35Abnormality of the ileum (HP:0001549)2.93347571
36Muscle fibrillation (HP:0010546)2.87246913
37Microretrognathia (HP:0000308)2.86673911
38Abnormal hemoglobin (HP:0011902)2.86332430
39Ragged-red muscle fibers (HP:0003200)2.86155199
40Acute lymphatic leukemia (HP:0006721)2.84788498
41Capillary hemangiomas (HP:0005306)2.84682560
42Chromsome breakage (HP:0040012)2.80945127
43Albinism (HP:0001022)2.71656003
44Coronal craniosynostosis (HP:0004440)2.68415716
45Ulnar bowing (HP:0003031)2.64726427
46Hypochromic microcytic anemia (HP:0004840)2.64703344
47Abnormal trabecular bone morphology (HP:0100671)2.61949794
48Reticulocytopenia (HP:0001896)2.61374023
49Basal cell carcinoma (HP:0002671)2.61168330
50Broad distal phalanx of finger (HP:0009836)2.58893603
51Hypoplasia of the radius (HP:0002984)2.57352166
52Abnormal mitochondria in muscle tissue (HP:0008316)2.55846949
53Testicular atrophy (HP:0000029)2.55684944
54Abnormality of the umbilical cord (HP:0010881)2.54572486
55Broad alveolar ridges (HP:0000187)2.52946379
56Hyperacusis (HP:0010780)2.52054099
57Anteriorly placed anus (HP:0001545)2.50586764
58Type 2 muscle fiber atrophy (HP:0003554)2.50510997
59Selective tooth agenesis (HP:0001592)2.49129363
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48402247
61Bifid uvula (HP:0000193)2.48395666
62Short thumb (HP:0009778)2.48353104
63Dysautonomia (HP:0002459)2.47249050
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46793167
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46793167
66Abnormal number of incisors (HP:0011064)2.45635311
67Abnormal number of erythroid precursors (HP:0012131)2.45059731
68Alacrima (HP:0000522)2.45020753
69Abnormality of glycolysis (HP:0004366)2.44562055
70Muscle fiber atrophy (HP:0100295)2.41975173
71Abnormal umbilical cord blood vessels (HP:0011403)2.40716555
72Single umbilical artery (HP:0001195)2.40716555
73Abnormality of the fetal cardiovascular system (HP:0010948)2.40716555
74Short chin (HP:0000331)2.39266198
75Premature ovarian failure (HP:0008209)2.38494349
76Abnormality of cells of the erythroid lineage (HP:0012130)2.37463710
77Hypotelorism (HP:0000601)2.37378025
78Breast hypoplasia (HP:0003187)2.37195438
79Acute necrotizing encephalopathy (HP:0006965)2.33811509
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33365212
81Hypertensive crisis (HP:0100735)2.32876318
82Cheilitis (HP:0100825)2.32739855
83Aplasia of the musculature (HP:0100854)2.32345993
84Congenital hip dislocation (HP:0001374)2.30719980
85Achilles tendon contracture (HP:0001771)2.30470014
86Proximal placement of thumb (HP:0009623)2.30362622
87Diaphragmatic weakness (HP:0009113)2.30349574
88Progressive external ophthalmoplegia (HP:0000590)2.28713085
89Duplicated collecting system (HP:0000081)2.23427750
90Turricephaly (HP:0000262)2.23109191
91Acute encephalopathy (HP:0006846)2.22423595
92Median cleft lip (HP:0000161)2.22208384
93Macrocytic anemia (HP:0001972)2.21867872
94Nephroblastoma (Wilms tumor) (HP:0002667)2.21485236
95Abnormality of the renal collecting system (HP:0004742)2.21313255
96IgA deficiency (HP:0002720)2.20180497
97Popliteal pterygium (HP:0009756)2.20100410
98Nonimmune hydrops fetalis (HP:0001790)2.19814602
99Hypochromic anemia (HP:0001931)2.18683631
100Increased serum pyruvate (HP:0003542)2.18097918
101Horseshoe kidney (HP:0000085)2.17829153
102Sparse eyelashes (HP:0000653)2.17190389
103Deviation of the thumb (HP:0009603)2.16299068
104Orthostatic hypotension (HP:0001278)2.16065909
105Vertebral hypoplasia (HP:0008417)2.15131745
106Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.15131745
107Birth length less than 3rd percentile (HP:0003561)2.13585416
108Aplasia/Hypoplasia of the uvula (HP:0010293)2.13506022
109Increased number of teeth (HP:0011069)2.13413590
110Abnormality of the aortic arch (HP:0012303)2.11831028
111Premature skin wrinkling (HP:0100678)2.11610962
112Cleft eyelid (HP:0000625)2.11237575
113Exertional dyspnea (HP:0002875)2.10526801
114Increased serum lactate (HP:0002151)2.10463608
115Increased intramyocellular lipid droplets (HP:0012240)2.10404328
116Increased CSF lactate (HP:0002490)2.10346241
117Abnormal respiratory motile cilium morphology (HP:0005938)2.09737969
118Abnormal respiratory epithelium morphology (HP:0012253)2.09737969
119Embryonal renal neoplasm (HP:0011794)2.07715365
120Increased hepatocellular lipid droplets (HP:0006565)2.07006449
121Meckel diverticulum (HP:0002245)2.06628097
122Hepatocellular necrosis (HP:0001404)2.05818841
123Abnormality of the preputium (HP:0100587)2.05154110
124Abnormalities of placenta or umbilical cord (HP:0001194)2.04569247
125Type I transferrin isoform profile (HP:0003642)2.03854380
126Abnormality of the labia minora (HP:0012880)2.03485674
127Mitochondrial inheritance (HP:0001427)2.03267550
128Facial cleft (HP:0002006)2.03099753
129Supernumerary spleens (HP:0009799)2.02857668
130Secondary amenorrhea (HP:0000869)1.99268600
131Decreased lacrimation (HP:0000633)1.99176645
132Amelogenesis imperfecta (HP:0000705)1.97410575
133Hypotrichosis (HP:0001006)1.96664347
134Gastrointestinal atresia (HP:0002589)1.96430264
135Respiratory difficulties (HP:0002880)1.95838610
136Dysphonia (HP:0001618)1.93169988
137Pancytopenia (HP:0001876)1.92064015
138Volvulus (HP:0002580)1.91911919
139Redundant skin (HP:0001582)1.90224561
140Lactic acidosis (HP:0003128)1.89645151
141Exercise intolerance (HP:0003546)1.89044279
142Increased muscle lipid content (HP:0009058)1.88932263
143Glossoptosis (HP:0000162)1.87679398
144Entropion (HP:0000621)1.87393415
145Abnormality of the Achilles tendon (HP:0005109)1.87229328
146Abnormality of reticulocytes (HP:0004312)1.86968518
147Pallor (HP:0000980)1.86503325
148Large for gestational age (HP:0001520)1.86031027
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.84764395
150Generalized amyotrophy (HP:0003700)1.84572879
151Male infertility (HP:0003251)1.84258883
152Choanal stenosis (HP:0000452)1.84228032
153Fasciculations (HP:0002380)1.83423048
154Aplastic anemia (HP:0001915)1.82416329
155Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82291710
156Lipid accumulation in hepatocytes (HP:0006561)1.81585891
157Abnormality of DNA repair (HP:0003254)1.80704256
158Joint stiffness (HP:0001387)1.80104136
159Myelodysplasia (HP:0002863)1.80046278
160Seborrheic dermatitis (HP:0001051)1.79271170
161Insomnia (HP:0100785)1.78294569
162Abnormality of the distal phalanges of the toes (HP:0010182)1.77859939
163Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77202279
164Hypoplasia of the ulna (HP:0003022)1.76022214
165Increased serum ferritin (HP:0003281)1.74956761
166Hypergonadotropic hypogonadism (HP:0000815)1.73459993
167Abnormality of the anterior horn cell (HP:0006802)1.73189009
168Degeneration of anterior horn cells (HP:0002398)1.73189009
169Tented upper lip vermilion (HP:0010804)1.72991479
170Hypokinesia (HP:0002375)1.72640088
171Septate vagina (HP:0001153)1.71397420
172Reduced antithrombin III activity (HP:0001976)1.71359048
173Hepatic necrosis (HP:0002605)1.69659365
174Spastic diplegia (HP:0001264)1.68224688
175Increased nuchal translucency (HP:0010880)1.66375003
176Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65153693
177Abnormal protein N-linked glycosylation (HP:0012347)1.65153693
178Abnormal protein glycosylation (HP:0012346)1.65153693
179Abnormal glycosylation (HP:0012345)1.65153693
180Cerebral edema (HP:0002181)1.64000677
181Long palpebral fissure (HP:0000637)1.63888847
182Hepatosplenomegaly (HP:0001433)1.63731653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.75715442
2ICK4.28814070
3MAP3K64.09189839
4DDR23.89310139
5VRK23.32619740
6SMG13.30777175
7PIM23.19586033
8MAP3K113.15326372
9PINK13.11018788
10TESK22.63375742
11TRIB32.60333217
12YES12.53944040
13CDK122.27695098
14MATK2.26581137
15PRKD22.20120733
16MKNK22.19740380
17PBK2.18283699
18CDK72.15940984
19FGR2.05241425
20DYRK31.99213824
21UHMK11.95632134
22AKT31.84905751
23EEF2K1.70758358
24DAPK11.68628125
25PAK41.66140135
26DYRK1B1.65556793
27KDR1.64886190
28MKNK11.61753566
29CSK1.60338667
30TYRO31.59242343
31WEE11.56033149
32TESK11.53257939
33MAP3K101.53052229
34TRPM71.51779238
35SRPK11.49967769
36PIM11.49082701
37STK161.46650007
38NME21.44318769
39TAOK21.43878712
40EIF2AK11.41900142
41SCYL21.38880412
42ERN11.37860566
43PLK11.37630243
44BMX1.36204933
45TSSK61.33295112
46CHEK21.33042918
47SIK11.30980990
48LATS21.30590968
49BUB11.29710684
50NEK11.27156426
51ARAF1.24609770
52PDGFRA1.19865437
53ATR1.19795584
54RPS6KL11.18866226
55RPS6KC11.18866226
56NME11.08141463
57RPS6KA61.04105688
58CDC70.99001876
59NEK20.98878132
60CDK60.98451184
61MAPK110.97208047
62TNK20.94224365
63TLK10.91257514
64STK40.88363506
65MST40.87794353
66BRSK10.86484606
67PLK40.84833878
68BRSK20.80649583
69AURKA0.80263560
70TAF10.80140209
71CDK80.79596852
72EPHA20.76726794
73DYRK20.75348000
74GSK3A0.74322995
75BCKDK0.73504009
76CDC42BPA0.73311765
77ABL20.73272879
78CSNK2A10.71404270
79AURKB0.71104142
80MAP2K30.70437804
81MAPKAPK30.70425640
82ZAK0.70382885
83RPS6KB20.70076388
84VRK10.69567385
85CHEK10.68654925
86ILK0.67101014
87PLK30.66996579
88LRRK20.66688162
89ERBB30.65363115
90CDK20.64656713
91LYN0.63696747
92MAP3K140.63169150
93CDK90.62767610
94HIPK20.62035338
95SIK30.60162596
96RPS6KB10.59222355
97RPS6KA40.58877355
98TBK10.58430825
99TTK0.58125411
100CLK10.56369585
101ATM0.56112050
102LIMK10.56043302
103CDK40.55897035
104IRAK30.54846713
105FLT30.54821659
106CSNK2A20.54074428
107RPS6KA10.53421762
108ALK0.52965282
109PDK20.50447340
110CSNK1G10.50049326
111PASK0.49893122
112IRAK40.47656443
113STK30.47306334
114PKN20.46805075
115MTOR0.45751854
116MAPK30.44458900
117EIF2AK20.43311746
118GRK60.42447531
119MAP4K10.41328106
120CDK10.41320718
121PRKAA10.40900987
122PRPF4B0.40193598
123FGFR40.39750470
124PRKCI0.39613452
125PTK60.38754551
126BLK0.38390892
127CDK11A0.38076976
128MAP2K20.37893167
129MAP3K30.36773557
130CSNK1G30.36219239
131MAPK40.35746925
132ERBB40.35552103
133MAPK10.34336317
134PTK20.33411595
135MAPK140.32532512
136RAF10.31872015
137MAPK100.30733867
138PAK10.28925791
139MAPKAPK20.28645729
140STK38L0.28059293
141PHKG10.27962310
142PHKG20.27962310
143IKBKB0.27846912
144LCK0.27726571
145BRAF0.24746013
146AKT10.23964216
147BRD40.23638368
148ACVR1B0.23131066
149AKT20.22993726
150MST1R0.22594703
151STK100.22435834
152MAP3K80.21923547

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.73371351
2Base excision repair_Homo sapiens_hsa034104.45110454
3DNA replication_Homo sapiens_hsa030304.26715300
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.39168736
5Homologous recombination_Homo sapiens_hsa034402.90930298
6Ribosome_Homo sapiens_hsa030102.89622328
7Spliceosome_Homo sapiens_hsa030402.89390711
8Nucleotide excision repair_Homo sapiens_hsa034202.83125122
9Fanconi anemia pathway_Homo sapiens_hsa034602.74483814
10Fatty acid biosynthesis_Homo sapiens_hsa000612.72662258
11RNA transport_Homo sapiens_hsa030132.53449511
12RNA polymerase_Homo sapiens_hsa030202.48491514
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06687671
14Sulfur relay system_Homo sapiens_hsa041222.00844916
15mRNA surveillance pathway_Homo sapiens_hsa030151.97117596
16Cell cycle_Homo sapiens_hsa041101.90850648
17p53 signaling pathway_Homo sapiens_hsa041151.88570303
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75112382
19Pyrimidine metabolism_Homo sapiens_hsa002401.69575784
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54860433
21Pentose phosphate pathway_Homo sapiens_hsa000301.51912547
22Hedgehog signaling pathway_Homo sapiens_hsa043401.49315938
23One carbon pool by folate_Homo sapiens_hsa006701.48133397
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47993983
25Primary immunodeficiency_Homo sapiens_hsa053401.47692207
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46489503
27Circadian rhythm_Homo sapiens_hsa047101.39546135
28Basal transcription factors_Homo sapiens_hsa030221.38965209
29Folate biosynthesis_Homo sapiens_hsa007901.32256563
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28241454
31Proteasome_Homo sapiens_hsa030501.28178611
32Arginine and proline metabolism_Homo sapiens_hsa003301.26919464
33Carbon metabolism_Homo sapiens_hsa012001.24850114
34Hippo signaling pathway_Homo sapiens_hsa043901.23585172
35Oxidative phosphorylation_Homo sapiens_hsa001901.20063070
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18456860
37Parkinsons disease_Homo sapiens_hsa050121.18055832
38Notch signaling pathway_Homo sapiens_hsa043301.17041529
39RNA degradation_Homo sapiens_hsa030181.14859458
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.12459865
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11102399
42Other glycan degradation_Homo sapiens_hsa005111.10573259
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08534595
44Non-homologous end-joining_Homo sapiens_hsa034501.08484584
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03865785
46Basal cell carcinoma_Homo sapiens_hsa052171.03784867
47TGF-beta signaling pathway_Homo sapiens_hsa043501.03387518
48Huntingtons disease_Homo sapiens_hsa050161.02099369
49Wnt signaling pathway_Homo sapiens_hsa043100.95461004
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91521661
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.87390910
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86922779
53Vitamin B6 metabolism_Homo sapiens_hsa007500.86854741
54Herpes simplex infection_Homo sapiens_hsa051680.81477560
55Purine metabolism_Homo sapiens_hsa002300.81437653
56Shigellosis_Homo sapiens_hsa051310.78767290
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.77260378
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76785611
59Bladder cancer_Homo sapiens_hsa052190.76468838
60Epstein-Barr virus infection_Homo sapiens_hsa051690.75729260
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75672548
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70584485
63Pyruvate metabolism_Homo sapiens_hsa006200.69189292
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69001499
65Adherens junction_Homo sapiens_hsa045200.68892927
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67890627
67mTOR signaling pathway_Homo sapiens_hsa041500.65946681
68MicroRNAs in cancer_Homo sapiens_hsa052060.65716914
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60598207
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60371268
71Sulfur metabolism_Homo sapiens_hsa009200.59303958
72Fatty acid elongation_Homo sapiens_hsa000620.56753170
73Viral carcinogenesis_Homo sapiens_hsa052030.55943224
74Thyroid cancer_Homo sapiens_hsa052160.54923151
75Oocyte meiosis_Homo sapiens_hsa041140.54533098
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53909526
77Alzheimers disease_Homo sapiens_hsa050100.53642352
78Arachidonic acid metabolism_Homo sapiens_hsa005900.53391240
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51940927
80Biosynthesis of amino acids_Homo sapiens_hsa012300.50675627
81Lysine degradation_Homo sapiens_hsa003100.49871016
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48786901
83HTLV-I infection_Homo sapiens_hsa051660.47320638
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46559112
85Measles_Homo sapiens_hsa051620.46035213
86Vibrio cholerae infection_Homo sapiens_hsa051100.44879254
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44681359
88Small cell lung cancer_Homo sapiens_hsa052220.43438108
89Fructose and mannose metabolism_Homo sapiens_hsa000510.43109844
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42620977
91Acute myeloid leukemia_Homo sapiens_hsa052210.42464312
92Pancreatic cancer_Homo sapiens_hsa052120.42409304
93Colorectal cancer_Homo sapiens_hsa052100.41797024
94Linoleic acid metabolism_Homo sapiens_hsa005910.39147332
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.37535131
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36552693
97Systemic lupus erythematosus_Homo sapiens_hsa053220.36122937
98N-Glycan biosynthesis_Homo sapiens_hsa005100.36105978
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35633424
100Glutathione metabolism_Homo sapiens_hsa004800.35022729
101Lysosome_Homo sapiens_hsa041420.33849307
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33691784
103Steroid biosynthesis_Homo sapiens_hsa001000.32921736
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.32766676
105Hematopoietic cell lineage_Homo sapiens_hsa046400.32139024
106Vitamin digestion and absorption_Homo sapiens_hsa049770.31256894
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29962830
108Chronic myeloid leukemia_Homo sapiens_hsa052200.29827838
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29392927
110Hepatitis B_Homo sapiens_hsa051610.28628103
111Pathways in cancer_Homo sapiens_hsa052000.27448228
112Legionellosis_Homo sapiens_hsa051340.26894323
113Salmonella infection_Homo sapiens_hsa051320.26201846
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.26177095
115Influenza A_Homo sapiens_hsa051640.24748509
116Non-small cell lung cancer_Homo sapiens_hsa052230.24722837
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24670283
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22736271
119Choline metabolism in cancer_Homo sapiens_hsa052310.22728839
120Antigen processing and presentation_Homo sapiens_hsa046120.22376210
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22325372
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21573598
123ErbB signaling pathway_Homo sapiens_hsa040120.21122176
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20908792
125Hepatitis C_Homo sapiens_hsa051600.20897462
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.20829381
127Selenocompound metabolism_Homo sapiens_hsa004500.20824627
128Protein export_Homo sapiens_hsa030600.20683504
129Viral myocarditis_Homo sapiens_hsa054160.20209785
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19879841
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18634782
132Galactose metabolism_Homo sapiens_hsa000520.18501702
133Apoptosis_Homo sapiens_hsa042100.18385098
134Metabolic pathways_Homo sapiens_hsa011000.18288245
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18069894
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.17849345
137Prostate cancer_Homo sapiens_hsa052150.17436049
138VEGF signaling pathway_Homo sapiens_hsa043700.16918479
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16045339
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.14594247
141MAPK signaling pathway_Homo sapiens_hsa040100.13342017

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