CCDC141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.97098815
2muscle filament sliding (GO:0030049)7.08316062
3actin-myosin filament sliding (GO:0033275)7.08316062
4sarcomere organization (GO:0045214)6.95866873
5myofibril assembly (GO:0030239)6.80858308
6actin-mediated cell contraction (GO:0070252)6.30508302
7cardiac muscle tissue morphogenesis (GO:0055008)6.23445916
8cardiac muscle contraction (GO:0060048)5.99962924
9cardiac muscle hypertrophy (GO:0003300)5.90874276
10regulation of relaxation of muscle (GO:1901077)5.83671384
11regulation of sarcomere organization (GO:0060297)5.75789079
12ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.73622813
13muscle tissue morphogenesis (GO:0060415)5.61055195
14striated muscle hypertrophy (GO:0014897)5.56724870
15negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.51838093
16cardiac muscle cell development (GO:0055013)5.49156611
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.27246203
18cardiac cell development (GO:0055006)5.26127575
19adult heart development (GO:0007512)5.22075113
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.15726774
21actomyosin structure organization (GO:0031032)5.12622190
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.05075410
23regulation of cardioblast differentiation (GO:0051890)4.99514087
24heart process (GO:0003015)4.95655062
25heart contraction (GO:0060047)4.95655062
26muscle hypertrophy (GO:0014896)4.95381893
27regulation of actin filament-based movement (GO:1903115)4.89409500
28actin filament-based movement (GO:0030048)4.81380026
29negative regulation of hormone biosynthetic process (GO:0032353)4.81004013
30bundle of His cell to Purkinje myocyte communication (GO:0086069)4.78680491
31regulation of the force of heart contraction (GO:0002026)4.66651556
32striated muscle contraction (GO:0006941)4.66273098
33regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.64164883
34heart trabecula formation (GO:0060347)4.63862617
35negative regulation of striated muscle cell apoptotic process (GO:0010664)4.59676213
36negative regulation of potassium ion transmembrane transport (GO:1901380)4.55809012
37regulation of skeletal muscle contraction (GO:0014819)4.52076254
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.46544825
39regulation of striated muscle contraction (GO:0006942)4.34918464
40ventricular cardiac muscle cell action potential (GO:0086005)4.31222097
41cardiac chamber formation (GO:0003207)4.20087695
42response to caffeine (GO:0031000)4.18757910
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.13357447
44response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.09540920
45adrenergic receptor signaling pathway (GO:0071875)4.06639365
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.02379116
47negative regulation of hormone metabolic process (GO:0032351)3.99978731
48atrial septum morphogenesis (GO:0060413)3.99881344
49cell communication by electrical coupling (GO:0010644)3.96215963
50positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.93547319
51regulation of ATPase activity (GO:0043462)3.93361741
52regulation of ATP catabolic process (GO:1903289)3.93361741
53relaxation of muscle (GO:0090075)3.92634516
54cardiac muscle hypertrophy in response to stress (GO:0014898)3.92566614
55muscle hypertrophy in response to stress (GO:0003299)3.92566614
56cardiac muscle adaptation (GO:0014887)3.92566614
57cell communication involved in cardiac conduction (GO:0086065)3.91097277
58outflow tract septum morphogenesis (GO:0003148)3.89121091
59cardiac right ventricle morphogenesis (GO:0003215)3.87077345
60endocardial cushion morphogenesis (GO:0003203)3.80607165
61regulation of acyl-CoA biosynthetic process (GO:0050812)3.75563628
62regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.75298294
63relaxation of cardiac muscle (GO:0055119)3.72117617
64negative regulation of protein localization to cell surface (GO:2000009)3.70231318
65regulation of glucocorticoid metabolic process (GO:0031943)3.69000193
66lymph vessel development (GO:0001945)3.68623875
67positive regulation of cardiac muscle tissue development (GO:0055025)3.67296213
68positive regulation of cardiac muscle cell proliferation (GO:0060045)3.65517664
69sequestering of extracellular ligand from receptor (GO:0035581)3.64578664
70cardiac muscle cell action potential (GO:0086001)3.60563944
71regulation of cell communication by electrical coupling (GO:0010649)3.59625290
72response to epinephrine (GO:0071871)3.59251381
73pericardium development (GO:0060039)3.58778188
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58428896
75positive regulation of cardiac muscle tissue growth (GO:0055023)3.58371292
76regulation of membrane repolarization (GO:0060306)3.55512402
77regulation of cardiac muscle contraction (GO:0055117)3.53084615
78cellular response to epinephrine stimulus (GO:0071872)3.51168556
79cardiac muscle cell action potential involved in contraction (GO:0086002)3.48244227
80vascular endothelial growth factor signaling pathway (GO:0038084)3.47998341
81regulation of heart rate (GO:0002027)3.45612089
82muscle fiber development (GO:0048747)3.45196563
83detection of calcium ion (GO:0005513)3.42861894
84regulation of transforming growth factor beta2 production (GO:0032909)3.42342005
85regulation of cardiac muscle cell differentiation (GO:2000725)3.41937733
86endothelium development (GO:0003158)3.39648902
87regulation of cardiac muscle cell contraction (GO:0086004)3.37918990
88gap junction assembly (GO:0016264)3.37184852
89regulation of striated muscle cell apoptotic process (GO:0010662)3.34558142
90trabecula formation (GO:0060343)3.33046604
91positive regulation of ATPase activity (GO:0032781)3.32555455
92positive regulation of ATP catabolic process (GO:1903291)3.32555455
93regulation of cofactor metabolic process (GO:0051193)3.31384227
94regulation of coenzyme metabolic process (GO:0051196)3.31384227
95regulation of cardiac muscle tissue development (GO:0055024)3.30181022
96regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.29341581
97regulation of skeletal muscle cell differentiation (GO:2001014)3.27603580
98striated muscle adaptation (GO:0014888)3.27440355
99tricarboxylic acid cycle (GO:0006099)3.25907053
100mesenchyme morphogenesis (GO:0072132)3.24545271
101embryonic heart tube development (GO:0035050)3.20452855
102heart valve formation (GO:0003188)3.19971528
103positive regulation of cardiac muscle cell differentiation (GO:2000727)3.18796449
104ventricular cardiac muscle cell development (GO:0055015)3.17699736
105sarcoplasmic reticulum calcium ion transport (GO:0070296)3.16966861
106striated muscle cell development (GO:0055002)3.16115344
107regulation of muscle contraction (GO:0006937)3.15300464
108plasma membrane repair (GO:0001778)3.14672836
109venous blood vessel morphogenesis (GO:0048845)3.14609410
110regulation of heart contraction (GO:0008016)3.14327693
111negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13896762
112regulation of cardiac muscle cell apoptotic process (GO:0010665)3.13735896
113positive regulation of heart growth (GO:0060421)3.13226695
114cardiac conduction (GO:0061337)3.09534311
115carnitine shuttle (GO:0006853)3.09074847
116surfactant homeostasis (GO:0043129)3.08246211
117cardiac ventricle formation (GO:0003211)3.07701441
118positive regulation of heart rate (GO:0010460)3.07171599
119response to inactivity (GO:0014854)3.04819232
120negative regulation of muscle cell apoptotic process (GO:0010656)3.03780023
121atrioventricular valve morphogenesis (GO:0003181)3.03422445
122positive regulation of muscle tissue development (GO:1901863)3.01504550
123regulation of heart rate by cardiac conduction (GO:0086091)2.99817527
124chemical homeostasis within a tissue (GO:0048875)2.99356647
125heart trabecula morphogenesis (GO:0061384)2.98035916
126relaxation of smooth muscle (GO:0044557)2.96749707
127regulation of muscle system process (GO:0090257)2.96541379
128regulation of cardiac muscle cell proliferation (GO:0060043)2.96329892
129cardiac septum development (GO:0003279)2.93209012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse4.11350705
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.71021774
3CDX2_19796622_ChIP-Seq_MESCs_Mouse2.59466725
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58901855
5GBX2_23144817_ChIP-Seq_PC3_Human2.41087332
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.36494550
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27322169
8FUS_26573619_Chip-Seq_HEK293_Human2.20843793
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11884387
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11631323
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08176057
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.03985693
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.03985693
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03972984
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.03487104
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.98564769
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.97928182
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95338112
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92154414
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.87444349
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.78190951
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77101475
23MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.76550781
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74075771
25* ISL1_27105846_Chip-Seq_CPCs_Mouse1.73255980
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72488963
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72417659
28STAT3_23295773_ChIP-Seq_U87_Human1.72222243
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71988988
30IGF1R_20145208_ChIP-Seq_DFB_Human1.69009470
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.67849985
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.67756233
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67529163
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67529163
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.65379392
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65009937
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64757907
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64757907
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64359693
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62888269
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62165956
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58999043
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58552541
44ZNF274_21170338_ChIP-Seq_K562_Hela1.56338369
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.54856419
46TCF4_23295773_ChIP-Seq_U87_Human1.54369504
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52390793
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51290950
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47511985
50BCAT_22108803_ChIP-Seq_LS180_Human1.46806733
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46018404
52SMAD4_21799915_ChIP-Seq_A2780_Human1.44584082
53EWS_26573619_Chip-Seq_HEK293_Human1.44021899
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43467537
55AHR_22903824_ChIP-Seq_MCF-7_Human1.42591286
56* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40730490
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.36286504
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.35075888
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33516285
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33448451
61TAF15_26573619_Chip-Seq_HEK293_Human1.32845980
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32832566
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32293033
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32246923
65GATA4_21415370_ChIP-Seq_HL-1_Mouse1.29245949
66ER_23166858_ChIP-Seq_MCF-7_Human1.28155716
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.28074182
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.28011206
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.27815431
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.27487721
71* NANOG_18555785_Chip-Seq_ESCs_Mouse1.27404651
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26292579
73* CJUN_26792858_Chip-Seq_BT549_Human1.26190010
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26107408
75TCF4_22108803_ChIP-Seq_LS180_Human1.24817384
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.24784617
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24693234
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24457474
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22866657
80TP53_18474530_ChIP-ChIP_U2OS_Human1.22778553
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22499440
82CBP_20019798_ChIP-Seq_JUKART_Human1.22127576
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22127576
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20895622
85* SOX2_19829295_ChIP-Seq_ESCs_Human1.20829124
86* NANOG_19829295_ChIP-Seq_ESCs_Human1.20829124
87VDR_22108803_ChIP-Seq_LS180_Human1.20525299
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20350833
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.20326339
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.19974353
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19626772
92AR_25329375_ChIP-Seq_VCAP_Human1.17747578
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17197000
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.15337977
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.15193212
96* P300_19829295_ChIP-Seq_ESCs_Human1.15121507
97* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14874259
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14827636
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14116940
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12834747
101TBL1_22424771_ChIP-Seq_293T_Human1.12743260
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12354319
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12054064
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11832060
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11832060
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11796277
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10878156
108RNF2_27304074_Chip-Seq_ESCs_Mouse1.09203763
109* P53_22387025_ChIP-Seq_ESCs_Mouse1.09011240
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08848721
111* CDX2_22108803_ChIP-Seq_LS180_Human1.08604260
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08297028
113* LXR_22158963_ChIP-Seq_LIVER_Mouse1.07673745
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07467388
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05922011
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05746499
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.05596258
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05469385
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05448846
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05055060
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04410425
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03964528
123* E2F1_18555785_Chip-Seq_ESCs_Mouse1.03806152
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.03470325
125TP53_16413492_ChIP-PET_HCT116_Human1.03045393
126* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02638297
127* SOX9_26525672_Chip-Seq_HEART_Mouse1.02540374
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02215092
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.02041912
130* OCT4_18555785_Chip-Seq_ESCs_Mouse1.01897314
131CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01165923
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01149223
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99682368
134* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99429883
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99262194
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98423243
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96176965
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95857548
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93937107
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.93534542
141ESR2_21235772_ChIP-Seq_MCF-7_Human0.92794933
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92762067
143EZH2_22144423_ChIP-Seq_EOC_Human0.92739357
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92642155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.07554647
2MP0004215_abnormal_myocardial_fiber4.45515248
3MP0004036_abnormal_muscle_relaxation4.07033043
4MP0000749_muscle_degeneration4.04117974
5MP0002837_dystrophic_cardiac_calcinosis3.96532977
6MP0005330_cardiomyopathy3.79311880
7MP0002972_abnormal_cardiac_muscle3.59158848
8MP0002102_abnormal_ear_morphology3.31495060
9MP0000751_myopathy3.25872902
10MP0008775_abnormal_heart_ventricle3.23952294
11MP0002127_abnormal_cardiovascular_syste3.00906994
12MP0005620_abnormal_muscle_contractility2.81623342
13MP0003137_abnormal_impulse_conducting2.78130125
14MP0006138_congestive_heart_failure2.77741255
15MP0010630_abnormal_cardiac_muscle2.77153387
16MP0004484_altered_response_of2.75086083
17MP0003828_pulmonary_edema2.70736755
18MP0001544_abnormal_cardiovascular_syste2.55384693
19MP0005385_cardiovascular_system_phenoty2.55384693
20MP0004087_abnormal_muscle_fiber2.49102831
21MP0003950_abnormal_plasma_membrane2.46177383
22MP0003646_muscle_fatigue2.45660465
23MP0004085_abnormal_heartbeat2.39616415
24MP0004510_myositis2.31801321
25MP0001879_abnormal_lymphatic_vessel2.24637589
26MP0010368_abnormal_lymphatic_system2.11371340
27MP0005451_abnormal_body_composition2.10280410
28MP0009697_abnormal_copulation2.05558535
29MP0004272_abnormal_basement_membrane1.90092943
30MP0005167_abnormal_blood-brain_barrier1.87490680
31MP0002106_abnormal_muscle_physiology1.87076246
32MP0004145_abnormal_muscle_electrophysio1.79684224
33MP0009384_cardiac_valve_regurgitation1.76123503
34MP0003567_abnormal_fetal_cardiomyocyte1.67238922
35MP0005369_muscle_phenotype1.63119326
36MP0003279_aneurysm1.61939948
37MP0000750_abnormal_muscle_regeneration1.58371631
38MP0002269_muscular_atrophy1.56928547
39MP0003221_abnormal_cardiomyocyte_apopto1.56263686
40MP0003941_abnormal_skin_development1.55815695
41MP0003122_maternal_imprinting1.51049939
42MP0001661_extended_life_span1.47134479
43MP0004147_increased_porphyrin_level1.46954966
44MP0005171_absent_coat_pigmentation1.34190198
45MP0005165_increased_susceptibility_to1.33896552
46MP0005377_hearing/vestibular/ear_phenot1.33077270
47MP0003878_abnormal_ear_physiology1.33077270
48MP0000767_abnormal_smooth_muscle1.29072937
49MP0000566_synostosis1.26016885
50MP0002332_abnormal_exercise_endurance1.25882666
51MP0000266_abnormal_heart_morphology1.22396878
52MP0003890_abnormal_embryonic-extraembry1.20994800
53MP0005670_abnormal_white_adipose1.17499737
54MP0000759_abnormal_skeletal_muscle1.14431315
55MP0005623_abnormal_meninges_morphology1.05195924
56MP0002128_abnormal_blood_circulation1.04548594
57MP0000462_abnormal_digestive_system1.04051987
58MP0004130_abnormal_muscle_cell1.02366648
59MP0004782_abnormal_surfactant_physiolog1.02095041
60MP0003937_abnormal_limbs/digits/tail_de0.99680319
61MP0002249_abnormal_larynx_morphology0.93408832
62MP0000747_muscle_weakness0.91875471
63MP0002254_reproductive_system_inflammat0.91475940
64MP0005085_abnormal_gallbladder_physiolo0.91133470
65MP0002108_abnormal_muscle_morphology0.88740161
66MP0003045_fibrosis0.88553898
67MP0000230_abnormal_systemic_arterial0.88484338
68MP0002009_preneoplasia0.87719713
69MP0002925_abnormal_cardiovascular_devel0.85072768
70MP0005595_abnormal_vascular_smooth0.84388336
71MP0004233_abnormal_muscle_weight0.82826234
72MP0005084_abnormal_gallbladder_morpholo0.77995470
73MP0009250_abnormal_appendicular_skeleto0.77926765
74MP0005248_abnormal_Harderian_gland0.77165814
75MP0006072_abnormal_retinal_apoptosis0.77004064
76MP0005408_hypopigmentation0.76258284
77MP0006036_abnormal_mitochondrial_physio0.75583816
78MP0003119_abnormal_digestive_system0.72421474
79MP0001984_abnormal_olfaction0.72397631
80MP0005253_abnormal_eye_physiology0.70607032
81MP0003566_abnormal_cell_adhesion0.69696316
82MP0002638_abnormal_pupillary_reflex0.66706755
83MP0001188_hyperpigmentation0.66387029
84MP0001784_abnormal_fluid_regulation0.65489015
85MP0008877_abnormal_DNA_methylation0.64033455
86MP0001614_abnormal_blood_vessel0.63665947
87MP0008004_abnormal_stomach_pH0.63368699
88MP0000343_altered_response_to0.62705011
89MP0008057_abnormal_DNA_replication0.62596017
90MP0005551_abnormal_eye_electrophysiolog0.62278689
91MP0008995_early_reproductive_senescence0.62091885
92MP0002234_abnormal_pharynx_morphology0.61172720
93MP0002233_abnormal_nose_morphology0.60772402
94MP0005380_embryogenesis_phenotype0.59234012
95MP0001672_abnormal_embryogenesis/_devel0.59234012
96MP0003121_genomic_imprinting0.59035112
97MP0000372_irregular_coat_pigmentation0.57314438
98MP0005083_abnormal_biliary_tract0.55251735
99MP0002697_abnormal_eye_size0.54947878
100MP0002735_abnormal_chemical_nociception0.53683696
101MP0002133_abnormal_respiratory_system0.52709200
102MP0005388_respiratory_system_phenotype0.52709200
103MP0002822_catalepsy0.52272294
104MP0000762_abnormal_tongue_morphology0.52233215
105MP0002295_abnormal_pulmonary_circulatio0.51500142
106MP0002938_white_spotting0.50796188
107MP0001485_abnormal_pinna_reflex0.49431058
108MP0003943_abnormal_hepatobiliary_system0.48836353
109MP0003948_abnormal_gas_homeostasis0.48673440
110MP0000733_abnormal_muscle_development0.47708106
111MP0005266_abnormal_metabolism0.46264528
112MP0003806_abnormal_nucleotide_metabolis0.45856980
113MP0002168_other_aberrant_phenotype0.45686086
114MP0003136_yellow_coat_color0.45643702
115MP0001486_abnormal_startle_reflex0.42857000
116MP0002088_abnormal_embryonic_growth/wei0.42628332
117MP0000516_abnormal_urinary_system0.41946053
118MP0005367_renal/urinary_system_phenotyp0.41946053
119MP0001986_abnormal_taste_sensitivity0.41942755
120MP0009379_abnormal_foot_pigmentation0.41377313
121MP0006035_abnormal_mitochondrial_morpho0.41363934
122MP0003935_abnormal_craniofacial_develop0.41327283
123MP0002109_abnormal_limb_morphology0.41217114
124MP0003984_embryonic_growth_retardation0.41072917
125MP0000639_abnormal_adrenal_gland0.40410722
126MP0005647_abnormal_sex_gland0.39904058
127MP0001175_abnormal_lung_morphology0.39638704
128MP0000049_abnormal_middle_ear0.39612488
129MP0002098_abnormal_vibrissa_morphology0.39429418
130MP0003385_abnormal_body_wall0.39064390
131MP0003115_abnormal_respiratory_system0.38926879
132MP0000427_abnormal_hair_cycle0.38858843
133MP0001299_abnormal_eye_distance/0.36560818
134MP0000534_abnormal_ureter_morphology0.35239346
135MP0005410_abnormal_fertilization0.34655677
136MP0002084_abnormal_developmental_patter0.34528897
137MP0003195_calcinosis0.34289128
138MP0001293_anophthalmia0.34163469
139MP0004142_abnormal_muscle_tone0.31106887
140MP0002086_abnormal_extraembryonic_tissu0.30109547
141MP0004197_abnormal_fetal_growth/weight/0.28988383

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.49212984
2Atrial fibrillation (HP:0005110)6.42667103
3Ventricular tachycardia (HP:0004756)6.23570169
4Exercise-induced muscle cramps (HP:0003710)5.99359603
5Calf muscle hypertrophy (HP:0008981)5.96174101
6Primary atrial arrhythmia (HP:0001692)5.90153781
7Supraventricular tachycardia (HP:0004755)5.65445530
8Supraventricular arrhythmia (HP:0005115)5.54282975
9Lipoatrophy (HP:0100578)5.23303538
10Muscle hypertrophy of the lower extremities (HP:0008968)5.22414593
11Abnormality of the calf musculature (HP:0001430)5.12063375
12Right ventricular cardiomyopathy (HP:0011663)4.88173335
13Syncope (HP:0001279)4.79891537
14Abnormality of the left ventricular outflow tract (HP:0011103)4.63271274
15Subaortic stenosis (HP:0001682)4.63271274
16Prolonged QT interval (HP:0001657)4.52081362
17Exercise-induced myalgia (HP:0003738)4.28405599
18Dilated cardiomyopathy (HP:0001644)4.23823880
19Ventricular arrhythmia (HP:0004308)4.17576586
20Hypoplastic heart (HP:0001961)3.88856185
21Hyporeflexia of lower limbs (HP:0002600)3.81885530
22Hypoplastic left heart (HP:0004383)3.80222826
23EMG: myopathic abnormalities (HP:0003458)3.66358633
24Palpitations (HP:0001962)3.56296245
25Hypoglycemic coma (HP:0001325)3.55647692
26Muscle fiber splitting (HP:0003555)3.53842386
27Distal lower limb muscle weakness (HP:0009053)3.47831008
28Congenital malformation of the right heart (HP:0011723)3.44073417
29Double outlet right ventricle (HP:0001719)3.44073417
30Myoglobinuria (HP:0002913)3.43213563
31Aplasia of the musculature (HP:0100854)3.23105195
32Abnormal EKG (HP:0003115)3.17933121
33Heart block (HP:0012722)3.13967304
34Left ventricular hypertrophy (HP:0001712)3.12987803
35Hip contracture (HP:0003273)3.10568545
36Atrioventricular block (HP:0001678)3.01360604
37Abnormal atrioventricular conduction (HP:0005150)2.92629135
38Abnormality of the ischium (HP:0003174)2.89256703
39Nemaline bodies (HP:0003798)2.86851600
40Bundle branch block (HP:0011710)2.84750063
41Pancreatic islet-cell hyperplasia (HP:0004510)2.83272327
42Asymmetric septal hypertrophy (HP:0001670)2.78380848
43Ventricular fibrillation (HP:0001663)2.71168223
44Hyperinsulinemic hypoglycemia (HP:0000825)2.69660846
45Generalized muscle weakness (HP:0003324)2.66419618
46Rhabdomyolysis (HP:0003201)2.65656347
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.64038064
48Limited hip movement (HP:0008800)2.56931073
49Palmoplantar keratoderma (HP:0000982)2.53108662
50Abnormal pancreas size (HP:0012094)2.44654603
51Pulmonary artery stenosis (HP:0004415)2.41709869
52Renal cortical cysts (HP:0000803)2.38578980
53Diaphragmatic weakness (HP:0009113)2.37432572
54Hypoglycemic seizures (HP:0002173)2.36117561
55Periauricular skin pits (HP:0100277)2.35480723
56Preauricular pit (HP:0004467)2.35480723
57Type 1 muscle fiber predominance (HP:0003803)2.34543161
58Popliteal pterygium (HP:0009756)2.33891847
59Steppage gait (HP:0003376)2.29201817
60Patent foramen ovale (HP:0001655)2.24883163
61Muscular dystrophy (HP:0003560)2.23117520
62EMG: neuropathic changes (HP:0003445)2.22334222
63Neonatal hypoglycemia (HP:0001998)2.20411249
64Bicuspid aortic valve (HP:0001647)2.19142573
65Neck muscle weakness (HP:0000467)2.17699128
66Ketoacidosis (HP:0001993)2.15494836
67Myotonia (HP:0002486)2.14093600
68Adactyly (HP:0009776)2.04962225
69Vitreoretinal degeneration (HP:0000655)2.03413516
70Ragged-red muscle fibers (HP:0003200)2.02636398
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01132942
72Muscle stiffness (HP:0003552)2.00800456
73Proximal tubulopathy (HP:0000114)1.98908417
74Cerebellar dysplasia (HP:0007033)1.97868093
75Increased connective tissue (HP:0009025)1.96643093
76Preaxial foot polydactyly (HP:0001841)1.96581023
77Generalized aminoaciduria (HP:0002909)1.95050631
78Aplasia cutis congenita (HP:0001057)1.93017514
79Mildly elevated creatine phosphokinase (HP:0008180)1.91717684
80Abnormality of the renal cortex (HP:0011035)1.90073385
81Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89641353
82Toxemia of pregnancy (HP:0100603)1.89515059
83Distal arthrogryposis (HP:0005684)1.89149529
84Abnormality of the foot musculature (HP:0001436)1.87344961
85Congestive heart failure (HP:0001635)1.85747645
86Hypoalphalipoproteinemia (HP:0003233)1.85540981
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.84780704
88Sudden cardiac death (HP:0001645)1.84659308
89Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84006113
90Dicarboxylic aciduria (HP:0003215)1.84006113
91Skin pits (HP:0100276)1.83749344
92Rimmed vacuoles (HP:0003805)1.82540598
93Hepatic necrosis (HP:0002605)1.81617982
94Acute necrotizing encephalopathy (HP:0006965)1.79999695
95Abnormality of the pubic bones (HP:0003172)1.79852472
96Partial duplication of thumb phalanx (HP:0009944)1.78711353
97Myelomeningocele (HP:0002475)1.78649733
98Exercise intolerance (HP:0003546)1.77971158
99Fetal akinesia sequence (HP:0001989)1.77791603
100Hypoplastic ischia (HP:0003175)1.77416578
101Acanthocytosis (HP:0001927)1.76733031
102Abnormal ventriculo-arterial connection (HP:0011563)1.75689010
103Transposition of the great arteries (HP:0001669)1.75689010
104Abnormal connection of the cardiac segments (HP:0011545)1.75689010
105Gowers sign (HP:0003391)1.73375726
106Confusion (HP:0001289)1.73352248
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.72399408
108Bradycardia (HP:0001662)1.72223631
109Ulnar deviation of finger (HP:0009465)1.72109109
110Areflexia of lower limbs (HP:0002522)1.69909642
111Abnormal mitochondria in muscle tissue (HP:0008316)1.69365784
112Chorioretinal atrophy (HP:0000533)1.68541695
113Esophageal varix (HP:0002040)1.67515165
114Type 2 muscle fiber atrophy (HP:0003554)1.67421873
115Decreased circulating renin level (HP:0003351)1.66606035
116Skull defect (HP:0001362)1.66366370
117Portal hypertension (HP:0001409)1.64334626
118Neoplasm of the small intestine (HP:0100833)1.63017533
119Depressed nasal tip (HP:0000437)1.61886883
120Cerebral edema (HP:0002181)1.61671666
121Foot dorsiflexor weakness (HP:0009027)1.61359356
122Muscle fiber inclusion bodies (HP:0100299)1.61283087
123Hyperglycemia (HP:0003074)1.61260947
124Acute encephalopathy (HP:0006846)1.60914773
125Childhood onset (HP:0011463)1.60270768
126Symptomatic seizures (HP:0011145)1.59528577
127Absent eyebrow (HP:0002223)1.58859063
128Central scotoma (HP:0000603)1.58465351
129Abnormality of fatty-acid metabolism (HP:0004359)1.57824791
130Abnormality of urine glucose concentration (HP:0011016)1.57743481
131Glycosuria (HP:0003076)1.57743481
132Difficulty running (HP:0009046)1.57565544
133Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.57510691
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57332030
135Abnormality of alanine metabolism (HP:0010916)1.57332030
136Hyperalaninemia (HP:0003348)1.57332030
137Cupped ear (HP:0000378)1.57014586
138Knee flexion contracture (HP:0006380)1.53944991
139Partial duplication of the phalanx of hand (HP:0009999)1.53246883
140Bell-shaped thorax (HP:0001591)1.51496702
141Chronic hepatic failure (HP:0100626)1.50282862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.41484972
2TIE14.30672600
3MYLK4.22736247
4ZAK3.50070112
5LMTK23.47624701
6STK243.23373559
7INSRR3.13173928
8PIK3CA2.51177949
9KDR2.45564709
10FRK2.43752795
11MUSK2.29476196
12STK38L2.18853974
13PHKG21.90401130
14PHKG11.90401130
15DMPK1.84286374
16ACVR1B1.78343990
17NUAK11.70231225
18PDK21.63565458
19TTN1.51742857
20AKT31.50569245
21BCKDK1.48184568
22CDC42BPA1.46177207
23GRK11.42839879
24TRPM71.35771975
25PKN21.24940735
26PTK2B1.20953509
27PRKG21.16376609
28MAPK121.12430365
29TXK1.11556086
30PLK41.11533040
31PRKAA21.10178142
32ROCK11.07918472
33MAP3K101.04346509
34WNK41.04104798
35PDK41.03739860
36PDK31.03739860
37MAP4K20.98371234
38NEK90.98319626
39PINK10.91338694
40SGK20.91177216
41GRK70.90585224
42LATS10.83971023
43CASK0.83539085
44CAMK2D0.82221888
45TNIK0.82064910
46ILK0.80163743
47PRKCE0.79713773
48MAP3K40.79107507
49WNK30.74785958
50PRPF4B0.74349069
51TGFBR20.72530890
52PRKAA10.71555477
53EPHB20.71425085
54IRAK30.70586776
55PRKD10.70228051
56BRD40.67554890
57PAK30.67160827
58MAPK70.64520972
59BCR0.63846616
60CAMK10.62084509
61DAPK30.61214005
62WNK10.60758906
63NLK0.60661450
64PIK3CG0.60157971
65STK40.59452891
66RET0.57951114
67EIF2AK20.57265725
68STK380.56666636
69OXSR10.56255670
70CAMK2A0.54733138
71PRKG10.53738999
72SIK30.53440493
73MARK30.52609820
74NEK60.52013986
75MAP3K50.51566243
76MKNK20.50953341
77SIK10.50952646
78AKT20.50636282
79SGK30.50607598
80CCNB10.50152657
81FLT30.49481922
82PKN10.49137465
83ERBB40.48928238
84SGK4940.48479911
85SGK2230.48479911
86LIMK10.48026707
87PLK20.47674214
88PRKACB0.46337748
89STK30.46059221
90MAP3K70.45127593
91ITK0.44928901
92PRKACA0.44459850
93TRIM280.44156854
94PDK10.42399265
95STK390.40310995
96IGF1R0.40290497
97NEK10.38851208
98TGFBR10.38595766
99MELK0.38532662
100FGFR20.38462169
101BMPR1B0.38443051
102MAP3K30.38106626
103RIPK10.37959873
104CAMK40.37670693
105PBK0.37507761
106FER0.37440954
107ERBB30.37321595
108PRKD30.36393036
109TEC0.34856525
110PDGFRA0.32987149
111PRKACG0.30510889
112ROCK20.29466693
113BRSK20.28334257
114SGK10.28004006
115MAP2K10.27083703
116TAOK20.25933405
117PRKCQ0.24641521
118CDK80.24506355
119MST40.24426873
120MAPKAPK30.24286360
121YES10.23769729
122STK110.23687481
123MAP3K120.23259079
124MAPK130.23091509
125PRKCA0.22839183
126MAPK40.21968349
127FGFR10.21248795
128EPHA30.20833167
129JAK20.20044266
130ATM0.19951891
131VRK10.19725185
132ADRBK10.19656657
133ADRBK20.18139985
134MAP2K20.18051239
135RPS6KA30.17825546

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.79930173
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.32481820
3Dilated cardiomyopathy_Homo sapiens_hsa054144.21913671
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.66297058
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.95275947
6Propanoate metabolism_Homo sapiens_hsa006402.70888787
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67212277
8Fatty acid degradation_Homo sapiens_hsa000712.55000866
9Oxidative phosphorylation_Homo sapiens_hsa001902.28920224
10Parkinsons disease_Homo sapiens_hsa050122.28108727
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94984219
12Fatty acid metabolism_Homo sapiens_hsa012121.93851324
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83169296
14Carbon metabolism_Homo sapiens_hsa012001.67166089
15Alzheimers disease_Homo sapiens_hsa050101.62408538
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57849080
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55580405
18Fatty acid elongation_Homo sapiens_hsa000621.55333723
19Adherens junction_Homo sapiens_hsa045201.52026563
20Huntingtons disease_Homo sapiens_hsa050161.51668534
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43761742
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40665442
23Renin secretion_Homo sapiens_hsa049241.40079008
24Starch and sucrose metabolism_Homo sapiens_hsa005001.35458967
25beta-Alanine metabolism_Homo sapiens_hsa004101.31368642
26Bile secretion_Homo sapiens_hsa049761.27141420
27PPAR signaling pathway_Homo sapiens_hsa033201.23510615
28HIF-1 signaling pathway_Homo sapiens_hsa040661.22412299
29Vitamin digestion and absorption_Homo sapiens_hsa049771.22300963
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19829957
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13913568
32Tryptophan metabolism_Homo sapiens_hsa003801.12887836
33Tight junction_Homo sapiens_hsa045301.12818288
34Pyruvate metabolism_Homo sapiens_hsa006201.11603552
35Viral myocarditis_Homo sapiens_hsa054161.07556430
36Focal adhesion_Homo sapiens_hsa045101.01615322
37RNA degradation_Homo sapiens_hsa030181.01358233
38Peroxisome_Homo sapiens_hsa041460.99090356
39Tyrosine metabolism_Homo sapiens_hsa003500.97544392
40Glucagon signaling pathway_Homo sapiens_hsa049220.97075442
41Arginine and proline metabolism_Homo sapiens_hsa003300.96700586
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96503020
43Phenylalanine metabolism_Homo sapiens_hsa003600.95841578
44Ovarian steroidogenesis_Homo sapiens_hsa049130.91081732
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.90426269
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89767947
47Arginine biosynthesis_Homo sapiens_hsa002200.88236754
48Linoleic acid metabolism_Homo sapiens_hsa005910.87726356
49Calcium signaling pathway_Homo sapiens_hsa040200.87021789
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86480522
51Nitrogen metabolism_Homo sapiens_hsa009100.86390452
52Mineral absorption_Homo sapiens_hsa049780.83890282
53ECM-receptor interaction_Homo sapiens_hsa045120.83552974
54Galactose metabolism_Homo sapiens_hsa000520.82975510
55Biosynthesis of amino acids_Homo sapiens_hsa012300.81705355
56Butanoate metabolism_Homo sapiens_hsa006500.80846109
57Fructose and mannose metabolism_Homo sapiens_hsa000510.77891791
58ABC transporters_Homo sapiens_hsa020100.77652109
59Fatty acid biosynthesis_Homo sapiens_hsa000610.75436825
60Basal cell carcinoma_Homo sapiens_hsa052170.75414250
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75139996
62Insulin resistance_Homo sapiens_hsa049310.73049035
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.72574127
64Glycerolipid metabolism_Homo sapiens_hsa005610.72187684
65Pancreatic secretion_Homo sapiens_hsa049720.72030530
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71155369
67Phototransduction_Homo sapiens_hsa047440.70645887
68Lysine degradation_Homo sapiens_hsa003100.67765140
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.65950708
70Amphetamine addiction_Homo sapiens_hsa050310.59272983
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59228432
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58707013
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58457143
74Insulin secretion_Homo sapiens_hsa049110.58173666
75Circadian rhythm_Homo sapiens_hsa047100.57682559
76Ether lipid metabolism_Homo sapiens_hsa005650.56698427
77Oxytocin signaling pathway_Homo sapiens_hsa049210.55956755
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.55212151
79Taste transduction_Homo sapiens_hsa047420.54061327
80cAMP signaling pathway_Homo sapiens_hsa040240.53894400
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.53298422
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53190888
83Hippo signaling pathway_Homo sapiens_hsa043900.53069728
84Selenocompound metabolism_Homo sapiens_hsa004500.51097800
85Regulation of autophagy_Homo sapiens_hsa041400.48050057
86Sulfur metabolism_Homo sapiens_hsa009200.47084393
87Salivary secretion_Homo sapiens_hsa049700.46964384
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46928875
89Circadian entrainment_Homo sapiens_hsa047130.45415820
90Complement and coagulation cascades_Homo sapiens_hsa046100.43570488
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42485864
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42070417
93Non-homologous end-joining_Homo sapiens_hsa034500.41705829
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41149849
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.40762508
96Basal transcription factors_Homo sapiens_hsa030220.40442914
97Dorso-ventral axis formation_Homo sapiens_hsa043200.40051810
98Melanogenesis_Homo sapiens_hsa049160.39797719
99Melanoma_Homo sapiens_hsa052180.39250212
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38939231
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38584487
102Serotonergic synapse_Homo sapiens_hsa047260.38248355
103Rap1 signaling pathway_Homo sapiens_hsa040150.37886415
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37760227
105Cholinergic synapse_Homo sapiens_hsa047250.36249310
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35319090
107Insulin signaling pathway_Homo sapiens_hsa049100.35190226
108Small cell lung cancer_Homo sapiens_hsa052220.34368056
109TGF-beta signaling pathway_Homo sapiens_hsa043500.33175223
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33119335
111Arachidonic acid metabolism_Homo sapiens_hsa005900.33051389
112Metabolic pathways_Homo sapiens_hsa011000.32930302
113Hedgehog signaling pathway_Homo sapiens_hsa043400.32183054
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31539616
115MAPK signaling pathway_Homo sapiens_hsa040100.31418011
116Proteoglycans in cancer_Homo sapiens_hsa052050.31012172
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.30686056
118Choline metabolism in cancer_Homo sapiens_hsa052310.30411700
119FoxO signaling pathway_Homo sapiens_hsa040680.29907102
120Protein digestion and absorption_Homo sapiens_hsa049740.29348913
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28709185
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.28379382
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28203979
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28134341
125Endometrial cancer_Homo sapiens_hsa052130.26949644
126Oocyte meiosis_Homo sapiens_hsa041140.26221945
127Olfactory transduction_Homo sapiens_hsa047400.25697627
128Long-term potentiation_Homo sapiens_hsa047200.25338407
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24598099
130Wnt signaling pathway_Homo sapiens_hsa043100.24340952
131Caffeine metabolism_Homo sapiens_hsa002320.24258147
132Retinol metabolism_Homo sapiens_hsa008300.23605219
133Morphine addiction_Homo sapiens_hsa050320.23143348
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23119129
135Gastric acid secretion_Homo sapiens_hsa049710.23107111

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