CCDC142

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.44561335
2positive regulation of gamma-delta T cell activation (GO:0046645)7.19343056
3regulation of gamma-delta T cell differentiation (GO:0045586)6.07429608
4negative regulation of cell killing (GO:0031342)5.77078784
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.77078784
6regulation of gamma-delta T cell activation (GO:0046643)5.49779528
7positive regulation of B cell differentiation (GO:0045579)5.29165327
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86969873
9B cell receptor signaling pathway (GO:0050853)4.86479341
10negative regulation of granulocyte differentiation (GO:0030853)4.80593622
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42408517
12fucose catabolic process (GO:0019317)4.36573488
13L-fucose metabolic process (GO:0042354)4.36573488
14L-fucose catabolic process (GO:0042355)4.36573488
15negative regulation of erythrocyte differentiation (GO:0045647)4.24138701
16regulation of B cell differentiation (GO:0045577)4.23054818
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19445566
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19445566
19regulation of granulocyte differentiation (GO:0030852)4.11855975
20tryptophan catabolic process (GO:0006569)3.91685184
21indole-containing compound catabolic process (GO:0042436)3.91685184
22indolalkylamine catabolic process (GO:0046218)3.91685184
23indolalkylamine metabolic process (GO:0006586)3.87583302
24positive thymic T cell selection (GO:0045059)3.78614620
25cellular response to zinc ion (GO:0071294)3.76206795
26antigen processing and presentation of endogenous antigen (GO:0019883)3.75061957
27water-soluble vitamin biosynthetic process (GO:0042364)3.74011121
28DNA deamination (GO:0045006)3.73244025
29negative regulation of telomere maintenance (GO:0032205)3.72880596
30positive regulation of granulocyte differentiation (GO:0030854)3.72731560
31regulation of B cell receptor signaling pathway (GO:0050855)3.71723295
32granulocyte differentiation (GO:0030851)3.67373073
33positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.66922397
34nonmotile primary cilium assembly (GO:0035058)3.57615319
35tryptophan metabolic process (GO:0006568)3.57026541
36kynurenine metabolic process (GO:0070189)3.54538797
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53477070
38embryonic hemopoiesis (GO:0035162)3.52954446
39regulation of erythrocyte differentiation (GO:0045646)3.52806031
40erythrocyte maturation (GO:0043249)3.52628738
41sulfation (GO:0051923)3.51805180
42negative regulation of mast cell activation (GO:0033004)3.51186789
43response to pheromone (GO:0019236)3.48506262
44positive regulation of prostaglandin secretion (GO:0032308)3.44941404
45synaptic transmission, cholinergic (GO:0007271)3.41808422
46negative thymic T cell selection (GO:0045060)3.41348064
47negative T cell selection (GO:0043383)3.37256306
48fucosylation (GO:0036065)3.34629658
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.33118521
50nephron tubule morphogenesis (GO:0072078)3.31693815
51nephron epithelium morphogenesis (GO:0072088)3.31693815
52megakaryocyte development (GO:0035855)3.25825249
53T cell migration (GO:0072678)3.25409307
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.24586821
55NADH dehydrogenase complex assembly (GO:0010257)3.24586821
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24586821
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23170696
58positive regulation of fatty acid transport (GO:2000193)3.22436081
59positive regulation of histone deacetylation (GO:0031065)3.21254550
60protein-cofactor linkage (GO:0018065)3.21228276
61natural killer cell differentiation (GO:0001779)3.19482002
62cellular ketone body metabolic process (GO:0046950)3.15821528
63histone H3-K36 demethylation (GO:0070544)3.11651300
64antigen processing and presentation via MHC class Ib (GO:0002475)3.10071369
65B cell homeostasis (GO:0001782)3.06589403
66thymic T cell selection (GO:0045061)3.05490697
67T cell homeostasis (GO:0043029)3.04905303
68regulation of action potential (GO:0098900)3.04805688
69lymphocyte homeostasis (GO:0002260)3.04695656
70mitochondrial respiratory chain complex assembly (GO:0033108)3.03845877
71NIK/NF-kappaB signaling (GO:0038061)3.03801472
72protein complex biogenesis (GO:0070271)3.03111508
73piRNA metabolic process (GO:0034587)3.02935426
74reciprocal DNA recombination (GO:0035825)3.02342655
75reciprocal meiotic recombination (GO:0007131)3.02342655
76ubiquinone biosynthetic process (GO:0006744)3.02116919
77negative regulation of phagocytosis (GO:0050765)3.01550216
78kidney morphogenesis (GO:0060993)3.01507243
79pyrimidine nucleobase catabolic process (GO:0006208)2.99854458
80adaptation of signaling pathway (GO:0023058)2.99160814
81myeloid dendritic cell activation (GO:0001773)2.97403816
82iron-sulfur cluster assembly (GO:0016226)2.97233418
83metallo-sulfur cluster assembly (GO:0031163)2.97233418
84positive regulation of icosanoid secretion (GO:0032305)2.96818143
85antigen receptor-mediated signaling pathway (GO:0050851)2.95928865
86regulation of hippo signaling (GO:0035330)2.94333875
87preassembly of GPI anchor in ER membrane (GO:0016254)2.94260972
88sulfate transmembrane transport (GO:1902358)2.93536101
89mature B cell differentiation (GO:0002335)2.92899669
90mitochondrial DNA metabolic process (GO:0032042)2.91326061
91cellular response to exogenous dsRNA (GO:0071360)2.91005313
92positive regulation of erythrocyte differentiation (GO:0045648)2.88884374
93T cell selection (GO:0045058)2.86967407
94regulation of hexokinase activity (GO:1903299)2.86819010
95regulation of glucokinase activity (GO:0033131)2.86819010
96positive T cell selection (GO:0043368)2.85936400
97positive regulation of defense response to virus by host (GO:0002230)2.85685193
98protein polyglutamylation (GO:0018095)2.84505751
99peristalsis (GO:0030432)2.84264015
100ubiquinone metabolic process (GO:0006743)2.83615050
101cornea development in camera-type eye (GO:0061303)2.82706360
102positive regulation of gastrulation (GO:2000543)2.82586575
103epithelial cilium movement (GO:0003351)2.82261436
104establishment of protein localization to mitochondrial membrane (GO:0090151)2.81306274
105Peyers patch development (GO:0048541)2.79544425
106mucosal-associated lymphoid tissue development (GO:0048537)2.79544425
107neural tube formation (GO:0001841)2.77749203
108response to interleukin-15 (GO:0070672)2.76958045
109anterograde synaptic vesicle transport (GO:0048490)2.76094615
110cellular response to ATP (GO:0071318)2.75788222
111indole-containing compound metabolic process (GO:0042430)2.75238478
112sulfate transport (GO:0008272)2.75164790
113T cell lineage commitment (GO:0002360)2.74624894
114regulation of cilium movement (GO:0003352)2.73569714
115regulation of regulatory T cell differentiation (GO:0045589)2.73127123
116ketone body metabolic process (GO:1902224)2.72531857
117meiotic chromosome segregation (GO:0045132)2.72315515
118response to laminar fluid shear stress (GO:0034616)2.71119350
119platelet formation (GO:0030220)2.70702167
120negative regulation of innate immune response (GO:0045824)2.70291061
121myeloid dendritic cell differentiation (GO:0043011)2.70087626
122positive regulation of gene expression, epigenetic (GO:0045815)2.69594343
123primary amino compound metabolic process (GO:1901160)2.68296498
124histone H3-K4 trimethylation (GO:0080182)2.67569408
125photoreceptor cell development (GO:0042461)2.67553396
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67113758
127leukocyte homeostasis (GO:0001776)2.66963757
128respiratory chain complex IV assembly (GO:0008535)2.66185132
129histone H3-K4 methylation (GO:0051568)2.65941187
130detection of light stimulus involved in sensory perception (GO:0050962)2.65874589
131detection of light stimulus involved in visual perception (GO:0050908)2.65874589
132peptidyl-lysine trimethylation (GO:0018023)2.64884354
133nucleobase catabolic process (GO:0046113)2.63186945
134regulation of interleukin-12 biosynthetic process (GO:0045075)2.62917416
135regulation of hypersensitivity (GO:0002883)2.62242833
136translesion synthesis (GO:0019985)2.61307951
137gamma-aminobutyric acid transport (GO:0015812)2.60844593
138regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.60724217
139neuronal action potential (GO:0019228)2.59814120
140DNA methylation involved in gamete generation (GO:0043046)2.59685005
141positive regulation of oligodendrocyte differentiation (GO:0048714)2.58703165
142cellular biogenic amine catabolic process (GO:0042402)2.58474747
143amine catabolic process (GO:0009310)2.58474747
144aromatic amino acid family catabolic process (GO:0009074)2.58194829
145positive regulation of developmental pigmentation (GO:0048087)2.58135364
1463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.57452973
147purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.57452973
148regulation of prostaglandin secretion (GO:0032306)2.56884500
149sequestering of actin monomers (GO:0042989)2.56441357
150histone H2A acetylation (GO:0043968)2.56161644
151defense response to protozoan (GO:0042832)2.55728974
152mRNA splice site selection (GO:0006376)2.55159158
153CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.55076408
154behavioral response to ethanol (GO:0048149)2.54454607
155spinal cord motor neuron differentiation (GO:0021522)2.54340252
156T cell receptor signaling pathway (GO:0050852)2.54240005
157pseudouridine synthesis (GO:0001522)2.54069031
158reflex (GO:0060004)2.52645895
159mannosylation (GO:0097502)2.52464575
160regulation of telomere maintenance (GO:0032204)2.52131570
161negative regulation of interleukin-2 production (GO:0032703)2.51913580
162regulation of chromatin binding (GO:0035561)2.51726203
163photoreceptor cell maintenance (GO:0045494)2.50972919
164replication fork processing (GO:0031297)2.50580874
165negative regulation of bone resorption (GO:0045779)2.49927630
166phasic smooth muscle contraction (GO:0014821)2.49241315
167positive regulation of Rap GTPase activity (GO:0032854)2.49135582
168activation of JUN kinase activity (GO:0007257)2.48702344
169spinal cord development (GO:0021510)2.48303036
170leukocyte cell-cell adhesion (GO:0007159)2.45342047
171dendritic cell differentiation (GO:0097028)2.45149976
172regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44727409
173platelet dense granule organization (GO:0060155)2.44139105
174NAD biosynthetic process (GO:0009435)2.43831338
175protein-DNA complex disassembly (GO:0032986)2.43811334
176nucleosome disassembly (GO:0006337)2.43811334
177negative regulation of lymphocyte mediated immunity (GO:0002707)2.43359136
178cilium morphogenesis (GO:0060271)2.42572690
179somite development (GO:0061053)2.41987478
180mannose metabolic process (GO:0006013)2.41984480
181response to muramyl dipeptide (GO:0032495)2.41311763
182renal tubule morphogenesis (GO:0061333)2.40708486
183negative regulation of T cell mediated immunity (GO:0002710)2.40418094
184mitochondrial RNA metabolic process (GO:0000959)2.40198587
185glycerophospholipid catabolic process (GO:0046475)2.39597987
186mast cell activation (GO:0045576)2.39065607
187regulation of monocyte differentiation (GO:0045655)2.38848652
188negative regulation of glycoprotein biosynthetic process (GO:0010561)2.38625549
189negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.37550753
190definitive hemopoiesis (GO:0060216)2.35059797
191DNA unwinding involved in DNA replication (GO:0006268)2.34609892
192regulation of ARF GTPase activity (GO:0032312)2.34409528
193mast cell activation involved in immune response (GO:0002279)2.33897904
194mast cell degranulation (GO:0043303)2.33897904
195tolerance induction (GO:0002507)2.33312453
196negative regulation of histone methylation (GO:0031061)2.31882577
197negative regulation of interleukin-12 production (GO:0032695)2.30017715
198regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29272361
199modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29084523
200modulation by symbiont of host immune response (GO:0052553)2.29084523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.82862189
2MYC_22102868_ChIP-Seq_BL_Human4.68503264
3ZNF274_21170338_ChIP-Seq_K562_Hela4.51062920
4EZH2_22144423_ChIP-Seq_EOC_Human4.50019375
5VDR_21846776_ChIP-Seq_THP-1_Human4.03148654
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.63482124
7SCL_19346495_ChIP-Seq_HPC-7_Human3.55906804
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49834723
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34255074
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95801782
11VDR_22108803_ChIP-Seq_LS180_Human2.93165023
12TCF7_22412390_ChIP-Seq_EML_Mouse2.81411603
13IGF1R_20145208_ChIP-Seq_DFB_Human2.68525774
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.68206773
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67352524
16VDR_24763502_ChIP-Seq_THP-1_Human2.65307798
17MAF_26560356_Chip-Seq_TH1_Human2.57823691
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56630826
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.54873055
20UTX_26944678_Chip-Seq_JUKART_Human2.53581490
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50025384
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.42741145
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42142651
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38215631
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.37543757
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30578424
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.28855140
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27833484
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27658120
30CIITA_25753668_ChIP-Seq_RAJI_Human2.23657848
31KDM2B_26808549_Chip-Seq_DND41_Human2.20766845
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19067833
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.16025034
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13793050
35GBX2_23144817_ChIP-Seq_PC3_Human2.11522214
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10023429
37RUNX_20019798_ChIP-Seq_JUKART_Human2.08683136
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07121218
39EST1_17652178_ChIP-ChIP_JURKAT_Human2.06907296
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06513164
41BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01988765
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99671915
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99423312
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97077630
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.96780961
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95561542
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92547106
48SPI1_23127762_ChIP-Seq_K562_Human1.91798187
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91234479
50MYB_26560356_Chip-Seq_TH1_Human1.90132958
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.89748997
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88934840
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88118272
54MYB_26560356_Chip-Seq_TH2_Human1.86444691
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85865297
56GATA1_22025678_ChIP-Seq_K562_Human1.85359906
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84763314
58LXR_22292898_ChIP-Seq_THP-1_Human1.84516558
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84011943
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.83339336
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.82996768
62SPI1_23547873_ChIP-Seq_NB4_Human1.80510708
63TP53_22573176_ChIP-Seq_HFKS_Human1.79491755
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.78080609
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77758956
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76968168
67MAF_26560356_Chip-Seq_TH2_Human1.76606236
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75337650
69ER_23166858_ChIP-Seq_MCF-7_Human1.73601047
70EWS_26573619_Chip-Seq_HEK293_Human1.72155653
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.70518738
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.70346445
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.68786465
74IRF1_19129219_ChIP-ChIP_H3396_Human1.68329964
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67950170
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65871488
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.65577556
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65562225
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64704676
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62666685
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.62202848
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59013457
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55740776
84REST_21632747_ChIP-Seq_MESCs_Mouse1.54820915
85MYC_18940864_ChIP-ChIP_HL60_Human1.54747047
86* VDR_23849224_ChIP-Seq_CD4+_Human1.53209188
87* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52663605
88P300_19829295_ChIP-Seq_ESCs_Human1.51627864
89FUS_26573619_Chip-Seq_HEK293_Human1.50926847
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50765637
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50583278
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.49500294
93GATA1_19941826_ChIP-Seq_K562_Human1.48695258
94ERA_21632823_ChIP-Seq_H3396_Human1.48483347
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48155618
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47451106
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47167124
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44433751
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44367796
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43253503
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43253503
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.43240329
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42685237
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42150418
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39438106
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.38134178
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37564926
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36857514
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36634915
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34924732
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.33052030
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33052030
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31746565
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31334818
115GATA3_27048872_Chip-Seq_THYMUS_Human1.25258703
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25239939
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24955606
118* NCOR_22424771_ChIP-Seq_293T_Human1.23708794
119TAF15_26573619_Chip-Seq_HEK293_Human1.21800399
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21111564
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19677804
122BCAT_22108803_ChIP-Seq_LS180_Human1.19268615
123SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18420811
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18262637
125HOXB7_26014856_ChIP-Seq_BT474_Human1.18149928
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16711487
127ELK1_19687146_ChIP-ChIP_HELA_Human1.16326612
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15879050
129CBP_20019798_ChIP-Seq_JUKART_Human1.15879050
130OCT4_20526341_ChIP-Seq_ESCs_Human1.15256363
131* SRF_21415370_ChIP-Seq_HL-1_Mouse1.13630879
132AR_20517297_ChIP-Seq_VCAP_Human1.13091797
133AR_21572438_ChIP-Seq_LNCaP_Human1.12837663
134DROSHA_22980978_ChIP-Seq_HELA_Human1.12832565
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12051030
136STAT3_23295773_ChIP-Seq_U87_Human1.11507026
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11301992
138MYC_19829295_ChIP-Seq_ESCs_Human1.10903816
139REST_18959480_ChIP-ChIP_MESCs_Mouse1.10262097
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10119011
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09534165
142GATA2_19941826_ChIP-Seq_K562_Human1.09346042
143PU_27001747_Chip-Seq_BMDM_Mouse1.08920814
144RNF2_27304074_Chip-Seq_NSC_Mouse1.08867400
145SOX2_19829295_ChIP-Seq_ESCs_Human1.08686624
146NANOG_19829295_ChIP-Seq_ESCs_Human1.08686624
147* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07759119
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07754531
149EED_16625203_ChIP-ChIP_MESCs_Mouse1.07646452
150AR_25329375_ChIP-Seq_VCAP_Human1.07556000
151NANOG_20526341_ChIP-Seq_ESCs_Human1.07222605
152NCOR1_26117541_ChIP-Seq_K562_Human1.06644289
153ELF1_20517297_ChIP-Seq_JURKAT_Human1.06438228
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06179712
155TCF4_23295773_ChIP-Seq_U87_Human1.05063499
156RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04473606
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04401111
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03103158
159EZH2_27294783_Chip-Seq_ESCs_Mouse1.02842640
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02075430
161CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01333933
162TAF2_19829295_ChIP-Seq_ESCs_Human1.00884490
163SPI1_20517297_ChIP-Seq_HL60_Human1.00855081
164RAC3_21632823_ChIP-Seq_H3396_Human1.00315436
165SALL1_21062744_ChIP-ChIP_HESCs_Human1.00250776
166KDM2B_26808549_Chip-Seq_K562_Human1.00022802
167SA1_27219007_Chip-Seq_ERYTHROID_Human0.99842419
168* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98944569
169P53_21459846_ChIP-Seq_SAOS-2_Human0.98628249
170JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98380932
171RUNX2_22187159_ChIP-Seq_PCA_Human0.98221537
172BCL6_27268052_Chip-Seq_Bcells_Human0.98122335
173HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97490264
174NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97449149
175TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97206430
176LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95507797
177DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94999386
178E2F1_21310950_ChIP-Seq_MCF-7_Human0.94485483
179PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94215008
180KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94115591
181EZH2_27304074_Chip-Seq_ESCs_Mouse0.93775756
182TCF4_22108803_ChIP-Seq_LS180_Human0.93527096
183PIAS1_25552417_ChIP-Seq_VCAP_Human0.92865776
184CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91369229
185NOTCH1_21737748_ChIP-Seq_TLL_Human0.89785023
186* FOXP3_21729870_ChIP-Seq_TREG_Human0.89637756
187SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.88930470
188PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88800265
189JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88597228
190SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88456309
191SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88348202
192E2F1_20622854_ChIP-Seq_HELA_Human0.88032335
193TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86285883
194DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85880870
195CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84294830
196CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84152243
197EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84037566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.76540428
2MP0002837_dystrophic_cardiac_calcinosis3.36187460
3MP0002102_abnormal_ear_morphology3.28468441
4MP0000685_abnormal_immune_system3.27616271
5MP0003195_calcinosis2.94908803
6MP0001800_abnormal_humoral_immune2.92201282
7MP0005174_abnormal_tail_pigmentation2.90130506
8MP0001835_abnormal_antigen_presentation2.80702280
9MP0001986_abnormal_taste_sensitivity2.71449190
10MP0002653_abnormal_ependyma_morphology2.71013518
11MP0003136_yellow_coat_color2.68383543
12MP0001545_abnormal_hematopoietic_system2.61639872
13MP0005397_hematopoietic_system_phenotyp2.61639872
14MP0003763_abnormal_thymus_physiology2.59668814
15MP0002166_altered_tumor_susceptibility2.59212953
16MP0000569_abnormal_digit_pigmentation2.58475060
17MP0003172_abnormal_lysosome_physiology2.56296776
18MP0002398_abnormal_bone_marrow2.55922432
19MP0005671_abnormal_response_to2.50822420
20MP0003436_decreased_susceptibility_to2.50414635
21MP0005387_immune_system_phenotype2.49652679
22MP0001790_abnormal_immune_system2.49652679
23MP0005645_abnormal_hypothalamus_physiol2.40934283
24MP0002452_abnormal_antigen_presenting2.38973785
25MP0002420_abnormal_adaptive_immunity2.33108150
26MP0002723_abnormal_immune_serum2.32315515
27MP0004808_abnormal_hematopoietic_stem2.31894219
28MP0001968_abnormal_touch/_nociception2.29294504
29MP0001819_abnormal_immune_cell2.27140339
30MP0000689_abnormal_spleen_morphology2.26151739
31MP0005551_abnormal_eye_electrophysiolog2.24703954
32MP0003183_abnormal_peptide_metabolism2.23638490
33MP0008877_abnormal_DNA_methylation2.20804059
34MP0005000_abnormal_immune_tolerance2.14969015
35MP0005075_abnormal_melanosome_morpholog2.13544118
36MP0000716_abnormal_immune_system2.12465609
37MP0002722_abnormal_immune_system2.11759367
38MP0006072_abnormal_retinal_apoptosis2.11144855
39MP0003300_gastrointestinal_ulcer2.09595472
40MP0005464_abnormal_platelet_physiology2.09397852
41MP0000703_abnormal_thymus_morphology2.06698705
42MP0003656_abnormal_erythrocyte_physiolo2.04829533
43MP0005423_abnormal_somatic_nervous2.03410719
44MP0002638_abnormal_pupillary_reflex2.02932909
45MP0004133_heterotaxia2.01599394
46MP0002938_white_spotting1.98842726
47MP0009278_abnormal_bone_marrow1.97155008
48MP0002419_abnormal_innate_immunity1.96714771
49MP0003866_abnormal_defecation1.93789394
50MP0008875_abnormal_xenobiotic_pharmacok1.93641258
51MP0003303_peritoneal_inflammation1.89559622
52MP0002429_abnormal_blood_cell1.88790377
53MP0002163_abnormal_gland_morphology1.86015403
54MP0002006_tumorigenesis1.84725621
55MP0005025_abnormal_response_to1.83764971
56MP0004142_abnormal_muscle_tone1.82908401
57MP0001873_stomach_inflammation1.69288790
58MP0000427_abnormal_hair_cycle1.64091627
59MP0009745_abnormal_behavioral_response1.59257487
60MP0002405_respiratory_system_inflammati1.58668435
61MP0008872_abnormal_physiological_respon1.55836483
62MP0004043_abnormal_pH_regulation1.54454396
63MP0005253_abnormal_eye_physiology1.53258166
64MP0000371_diluted_coat_color1.52272797
65MP0003646_muscle_fatigue1.50481052
66MP0002735_abnormal_chemical_nociception1.49710771
67MP0002272_abnormal_nervous_system1.49169795
68MP0002876_abnormal_thyroid_physiology1.49147639
69MP0006276_abnormal_autonomic_nervous1.45073846
70MP0002160_abnormal_reproductive_system1.44927021
71MP0005646_abnormal_pituitary_gland1.44681147
72MP0005058_abnormal_lysosome_morphology1.44667830
73MP0008961_abnormal_basal_metabolism1.40154611
74MP0000631_abnormal_neuroendocrine_gland1.38704454
75MP0003283_abnormal_digestive_organ1.38323138
76MP0005171_absent_coat_pigmentation1.37628235
77MP0002909_abnormal_adrenal_gland1.35260745
78MP0003011_delayed_dark_adaptation1.34013674
79MP0009046_muscle_twitch1.32768463
80MP0001502_abnormal_circadian_rhythm1.32447681
81MP0005084_abnormal_gallbladder_morpholo1.32105066
82MP0004947_skin_inflammation1.31493426
83MP0010155_abnormal_intestine_physiology1.30865594
84MP0000015_abnormal_ear_pigmentation1.30827058
85MP0002572_abnormal_emotion/affect_behav1.29604588
86MP0002148_abnormal_hypersensitivity_rea1.27603919
87MP0009785_altered_susceptibility_to1.25528565
88MP0009840_abnormal_foam_cell1.24195540
89MP0002928_abnormal_bile_duct1.21206989
90MP0001845_abnormal_inflammatory_respons1.20658066
91MP0005379_endocrine/exocrine_gland_phen1.20252109
92MP0004510_myositis1.18330452
93MP0008995_early_reproductive_senescence1.18007281
94MP0006292_abnormal_olfactory_placode1.17925071
95MP0000490_abnormal_crypts_of1.15510469
96MP0001485_abnormal_pinna_reflex1.15298149
97MP0003890_abnormal_embryonic-extraembry1.14851071
98MP0001853_heart_inflammation1.14112010
99MP0001529_abnormal_vocalization1.13635983
100MP0005386_behavior/neurological_phenoty1.13211437
101MP0004924_abnormal_behavior1.13211437
102MP0001984_abnormal_olfaction1.12754170
103MP0005389_reproductive_system_phenotype1.12710980
104MP0004742_abnormal_vestibular_system1.12020249
105MP0001501_abnormal_sleep_pattern1.11326475
106MP0002064_seizures1.11120404
107MP0004885_abnormal_endolymph1.10873099
108MP0002733_abnormal_thermal_nociception1.09638222
109MP0008789_abnormal_olfactory_epithelium1.09579492
110MP0008058_abnormal_DNA_repair1.09368953
111MP0001970_abnormal_pain_threshold1.09366485
112MP0010386_abnormal_urinary_bladder1.09328699
113MP0002557_abnormal_social/conspecific_i1.09085129
114MP0006082_CNS_inflammation1.09021453
115MP0005195_abnormal_posterior_eye1.08706222
116MP0002933_joint_inflammation1.07909031
117MP0000383_abnormal_hair_follicle1.07042078
118MP0003787_abnormal_imprinting1.04979965
119MP0000372_irregular_coat_pigmentation1.04564333
120MP0005310_abnormal_salivary_gland1.04487248
121MP0000609_abnormal_liver_physiology1.04421386
122MP0005670_abnormal_white_adipose1.03702087
123MP0002075_abnormal_coat/hair_pigmentati1.02861912
124MP0008469_abnormal_protein_level1.01837147
125MP0009333_abnormal_splenocyte_physiolog1.00362848
126MP0002751_abnormal_autonomic_nervous0.99387729
127MP0003252_abnormal_bile_duct0.98106253
128MP0002089_abnormal_postnatal_growth/wei0.97573452
129MP0000465_gastrointestinal_hemorrhage0.97540956
130MP0002277_abnormal_respiratory_mucosa0.95804942
131MP0002234_abnormal_pharynx_morphology0.95072863
132MP0000538_abnormal_urinary_bladder0.94900158
133MP0002822_catalepsy0.94645683
134MP0002752_abnormal_somatic_nervous0.94387333
135MP0001905_abnormal_dopamine_level0.94304464
136MP0000026_abnormal_inner_ear0.94194027
137MP0002736_abnormal_nociception_after0.93911216
138MP0001324_abnormal_eye_pigmentation0.93512198
139MP0008770_decreased_survivor_rate0.93358964
140MP0005448_abnormal_energy_balance0.92756144
141MP0002019_abnormal_tumor_incidence0.92303013
142MP0002282_abnormal_trachea_morphology0.92139032
143MP0002095_abnormal_skin_pigmentation0.92114874
144MP0000778_abnormal_nervous_system0.91126172
145MP0002139_abnormal_hepatobiliary_system0.90467088
146MP0002138_abnormal_hepatobiliary_system0.90213985
147MP0010329_abnormal_lipoprotein_level0.89019553
148MP0003077_abnormal_cell_cycle0.88286164
149MP0005360_urolithiasis0.87779973
150MP0001486_abnormal_startle_reflex0.87726876
151MP0003879_abnormal_hair_cell0.87016175
152MP0000049_abnormal_middle_ear0.86449662
153MP0002067_abnormal_sensory_capabilities0.84681910
154MP0005085_abnormal_gallbladder_physiolo0.84236425
155MP0005409_darkened_coat_color0.83824814
156MP0004381_abnormal_hair_follicle0.83032471
157MP0002063_abnormal_learning/memory/cond0.82689888
158MP0001348_abnormal_lacrimal_gland0.82409398
159MP0000604_amyloidosis0.80866998
160MP0003045_fibrosis0.80499614
161MP0005083_abnormal_biliary_tract0.80170766
162MP0005499_abnormal_olfactory_system0.78955702
163MP0005394_taste/olfaction_phenotype0.78955702
164MP0003880_abnormal_central_pattern0.77765293
165MP0001764_abnormal_homeostasis0.77244010
166MP0010094_abnormal_chromosome_stability0.77217132
167MP0002184_abnormal_innervation0.76319532
168MP0001533_abnormal_skeleton_physiology0.76131863
169MP0005220_abnormal_exocrine_pancreas0.75664684
170MP0003786_premature_aging0.73701358
171MP0005257_abnormal_intraocular_pressure0.73502785
172MP0010352_gastrointestinal_tract_polyps0.73009379
173MP0002210_abnormal_sex_determination0.72710610
174MP0000858_altered_metastatic_potential0.72394512
175MP0005365_abnormal_bile_salt0.71056056
176MP0000598_abnormal_liver_morphology0.70767317
177MP0004147_increased_porphyrin_level0.70159286
178MP0008874_decreased_physiological_sensi0.70109922
179MP0002970_abnormal_white_adipose0.69991168
180MP0003091_abnormal_cell_migration0.69777341
181MP0008007_abnormal_cellular_replicative0.68684594
182MP0003868_abnormal_feces_composition0.66237510
183MP0003448_altered_tumor_morphology0.65647735
184MP0003693_abnormal_embryo_hatching0.62415436
185MP0003191_abnormal_cellular_cholesterol0.61706031

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)5.05155161
2True hermaphroditism (HP:0010459)4.35725354
3Pancreatic fibrosis (HP:0100732)4.17818533
4Gastrointestinal inflammation (HP:0004386)4.13361178
5Inflammation of the large intestine (HP:0002037)4.11728923
6Colitis (HP:0002583)4.01065815
7Molar tooth sign on MRI (HP:0002419)3.96084236
8Abnormality of midbrain morphology (HP:0002418)3.96084236
9Type II lissencephaly (HP:0007260)3.88771407
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.88477017
11Recurrent viral infections (HP:0004429)3.70006703
12Abnormality of the fingertips (HP:0001211)3.61370229
13Nephronophthisis (HP:0000090)3.56978446
14Chronic otitis media (HP:0000389)3.55108464
15Prolonged bleeding time (HP:0003010)3.47652262
16Recurrent fungal infections (HP:0002841)3.47598276
17Congenital stationary night blindness (HP:0007642)3.44522800
18IgM deficiency (HP:0002850)3.34187609
19Panhypogammaglobulinemia (HP:0003139)3.26286231
20Cystic liver disease (HP:0006706)3.21611026
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.20097051
22Pendular nystagmus (HP:0012043)3.20005988
23Recurrent bacterial skin infections (HP:0005406)3.19533073
24Cellulitis (HP:0100658)3.15978324
25Abnormal rod and cone electroretinograms (HP:0008323)3.15076282
26Abnormality of the heme biosynthetic pathway (HP:0010472)3.12983404
27Abnormality of the renal cortex (HP:0011035)3.11509168
28Cerebellar dysplasia (HP:0007033)3.10528274
29Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06829361
30Abolished electroretinogram (ERG) (HP:0000550)3.06121927
31Lissencephaly (HP:0001339)3.04634279
32Recurrent abscess formation (HP:0002722)3.02383997
33Abnormality of the renal medulla (HP:0100957)3.00661054
34Agammaglobulinemia (HP:0004432)2.97132331
35Severe visual impairment (HP:0001141)2.87153369
36Tubular atrophy (HP:0000092)2.85127844
37Medial flaring of the eyebrow (HP:0010747)2.79546692
38Chronic hepatic failure (HP:0100626)2.79415650
39Acanthocytosis (HP:0001927)2.78019676
40Abnormality of the thoracic spine (HP:0100711)2.77199870
41Anencephaly (HP:0002323)2.75296347
42Attenuation of retinal blood vessels (HP:0007843)2.71044285
43Loss of speech (HP:0002371)2.70415746
44Abnormal platelet function (HP:0011869)2.69241543
45Impaired platelet aggregation (HP:0003540)2.69241543
46Recurrent gram-negative bacterial infections (HP:0005420)2.69070083
47Increased IgE level (HP:0003212)2.67629917
48Albinism (HP:0001022)2.66470639
49Abnormality of B cell number (HP:0010975)2.65624594
50B lymphocytopenia (HP:0010976)2.65624594
51Bile duct proliferation (HP:0001408)2.65574239
52Abnormal biliary tract physiology (HP:0012439)2.65574239
53Eczematoid dermatitis (HP:0000976)2.63201218
54Epistaxis (HP:0000421)2.61056645
55Recurrent skin infections (HP:0001581)2.58794575
56Sclerocornea (HP:0000647)2.58316471
57Hyperventilation (HP:0002883)2.57328553
58Abnormality of the pons (HP:0007361)2.56894306
59Patellar aplasia (HP:0006443)2.56546097
60Recurrent cutaneous fungal infections (HP:0011370)2.54462058
61Chronic mucocutaneous candidiasis (HP:0002728)2.54462058
62Concave nail (HP:0001598)2.52479594
63Abnormal number of erythroid precursors (HP:0012131)2.51635665
64Hypoplasia of the pons (HP:0012110)2.50776020
65Mediastinal lymphadenopathy (HP:0100721)2.47291326
66Aplasia/Hypoplasia of the patella (HP:0006498)2.46269004
67Abnormal drinking behavior (HP:0030082)2.46125374
68Polydipsia (HP:0001959)2.46125374
69Thrombocytosis (HP:0001894)2.40957026
70Meningitis (HP:0001287)2.39650871
71Visual hallucinations (HP:0002367)2.39646745
72T lymphocytopenia (HP:0005403)2.39090838
73Large for gestational age (HP:0001520)2.37435105
74Protruding tongue (HP:0010808)2.35607791
75Pustule (HP:0200039)2.33750034
76Papilloma (HP:0012740)2.33723912
77Verrucae (HP:0200043)2.33723912
78Nephrogenic diabetes insipidus (HP:0009806)2.33277376
79Gait imbalance (HP:0002141)2.32101601
80Inability to walk (HP:0002540)2.29739964
81Rib fusion (HP:0000902)2.28434134
82Congenital primary aphakia (HP:0007707)2.25902052
83Gingivitis (HP:0000230)2.25652822
84Renal cortical cysts (HP:0000803)2.25272087
85Severe muscular hypotonia (HP:0006829)2.25071034
86Furrowed tongue (HP:0000221)2.24268252
873-Methylglutaconic aciduria (HP:0003535)2.23358476
88Chest pain (HP:0100749)2.23042299
89Bony spicule pigmentary retinopathy (HP:0007737)2.23008325
90Recurrent bronchitis (HP:0002837)2.22834472
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.22811138
92Progressive inability to walk (HP:0002505)2.21786317
93Macroorchidism (HP:0000053)2.21705521
94Hyperacusis (HP:0010780)2.20484305
95Dysostosis multiplex (HP:0000943)2.20437986
96Congenital hepatic fibrosis (HP:0002612)2.20007685
97Decreased circulating renin level (HP:0003351)2.19371254
98Keratoconus (HP:0000563)2.19014046
99Increased corneal curvature (HP:0100692)2.19014046
100Prominent nose (HP:0000448)2.17930009
101Gingival bleeding (HP:0000225)2.15808533
102Amelogenesis imperfecta (HP:0000705)2.15062884
103Basal cell carcinoma (HP:0002671)2.14772685
104Myositis (HP:0100614)2.14561709
105Ragged-red muscle fibers (HP:0003200)2.14320011
106Abnormality of T cell number (HP:0011839)2.14120261
107Thoracic kyphosis (HP:0002942)2.14084838
108Abnormality of T cells (HP:0002843)2.12959639
109Dynein arm defect of respiratory motile cilia (HP:0012255)2.12138446
110Absent/shortened dynein arms (HP:0200106)2.12138446
111Focal motor seizures (HP:0011153)2.11822312
112Abnormality of T cell physiology (HP:0011840)2.10864799
113Cerebral aneurysm (HP:0004944)2.10631657
114Stomach cancer (HP:0012126)2.10334641
115Hypothermia (HP:0002045)2.07273581
116Bilateral microphthalmos (HP:0007633)2.06959951
117Neoplasm of the heart (HP:0100544)2.06662211
118Elevated erythrocyte sedimentation rate (HP:0003565)2.04324375
119Aplasia/Hypoplasia of the uvula (HP:0010293)2.03613980
120Decreased central vision (HP:0007663)2.02331613
121Abnormality of oral frenula (HP:0000190)2.01632116
122Long toe (HP:0010511)2.01268410
123Generalized hypopigmentation (HP:0007513)2.01126829
124Postaxial foot polydactyly (HP:0001830)2.00931150
125Colon cancer (HP:0003003)2.00865673
126Hypochromic anemia (HP:0001931)2.00764382
127Abnormality of cells of the erythroid lineage (HP:0012130)1.99085626
128Pachygyria (HP:0001302)1.98955183
129Ependymoma (HP:0002888)1.98731572
130Male pseudohermaphroditism (HP:0000037)1.96933823
131Autoimmune thrombocytopenia (HP:0001973)1.96343985
132Hemiplegia (HP:0002301)1.94401312
133Duplicated collecting system (HP:0000081)1.93799361
134Chronic obstructive pulmonary disease (HP:0006510)1.93258432
135Obstructive lung disease (HP:0006536)1.93258432
136Global brain atrophy (HP:0002283)1.93050026
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92962459
138Abnormality of polysaccharide metabolism (HP:0011012)1.92962459
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92962459
140Vaginal atresia (HP:0000148)1.92795709
141Pallor (HP:0000980)1.92365478
142Congenital, generalized hypertrichosis (HP:0004540)1.91985023
143Ankyloglossia (HP:0010296)1.91685790
144Poikilocytosis (HP:0004447)1.91570617
145Genital tract atresia (HP:0001827)1.91073120
146Reticulocytosis (HP:0001923)1.90787572
147Iris hypopigmentation (HP:0007730)1.90118683
148Hypoplasia of the thymus (HP:0000778)1.89337464
149Mucopolysacchariduria (HP:0008155)1.89267898
150Urinary glycosaminoglycan excretion (HP:0003541)1.89267898
151Abnormality of DNA repair (HP:0003254)1.87991263
152Hyperglycinuria (HP:0003108)1.87245654
153Mitochondrial inheritance (HP:0001427)1.86186131
154Spontaneous hematomas (HP:0007420)1.85580335
155Abnormality of the renal collecting system (HP:0004742)1.85532862
156Recurrent sinusitis (HP:0011108)1.85102473
157Absent thumb (HP:0009777)1.85074457
158Abnormal respiratory motile cilium morphology (HP:0005938)1.83062873
159Abnormal respiratory epithelium morphology (HP:0012253)1.83062873
160Gaze-evoked nystagmus (HP:0000640)1.81834119
161Disproportionate short-trunk short stature (HP:0003521)1.81621136
162Premature skin wrinkling (HP:0100678)1.81209508
163Eosinophilia (HP:0001880)1.79813909
164Lipid accumulation in hepatocytes (HP:0006561)1.78745758
165Lymphopenia (HP:0001888)1.78650399
166Striae distensae (HP:0001065)1.78485759
167Genetic anticipation (HP:0003743)1.77957645
168Chorioretinal atrophy (HP:0000533)1.76937596
169Optic nerve coloboma (HP:0000588)1.76218192
170Increased CSF lactate (HP:0002490)1.76121735
171Ketosis (HP:0001946)1.76073907
172Cheilitis (HP:0100825)1.75190094
173Prostate neoplasm (HP:0100787)1.74992321
174Abnormality of cells of the lymphoid lineage (HP:0012140)1.74803082
175Methylmalonic aciduria (HP:0012120)1.74040593
176Abnormality of the prostate (HP:0008775)1.73834812
177Polyuria (HP:0000103)1.73030114
178Dandy-Walker malformation (HP:0001305)1.73027137
179Mitral stenosis (HP:0001718)1.72938255
180Periodontitis (HP:0000704)1.72808057
181Preaxial hand polydactyly (HP:0001177)1.72237379
182Gastrointestinal stroma tumor (HP:0100723)1.72058525
183Progressive cerebellar ataxia (HP:0002073)1.72005783
184Occipital encephalocele (HP:0002085)1.71634659
185Thyroiditis (HP:0100646)1.71241403
186Menorrhagia (HP:0000132)1.71162319
187Gonadotropin excess (HP:0000837)1.71136853
188Ocular albinism (HP:0001107)1.71117611
189Tachypnea (HP:0002789)1.70659444
190Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70638141
191Abnormality of alanine metabolism (HP:0010916)1.70638141
192Hyperalaninemia (HP:0003348)1.70638141
193Neutropenia (HP:0001875)1.70064344
194Aplasia/Hypoplasia of the tibia (HP:0005772)1.69926344
195Bruising susceptibility (HP:0000978)1.69737753
196Myocardial infarction (HP:0001658)1.69696436
197Hypoalbuminemia (HP:0003073)1.69657043
198Abnormal albumin level (HP:0012116)1.69657043
199Clumsiness (HP:0002312)1.67341795
200Ketoacidosis (HP:0001993)1.66595683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.86841899
2TLK14.42724662
3ZAK4.24434328
4MAP4K13.94432374
5WNK43.38621027
6MAP3K103.26501708
7TNIK3.11745114
8EEF2K3.06603473
9WNK33.01159748
10CASK2.91424543
11SIK22.74479188
12MAP4K22.70137329
13TNK22.57633809
14ERN12.44740722
15BMPR1B2.37432591
16KIT2.18769039
17GRK12.17582082
18TYK22.15515172
19MAP3K72.12499048
20MAP3K132.10294014
21GRK62.02830399
22MAP3K41.91459952
23NUAK11.84952119
24CCNB11.70019375
25STK391.66864813
26ACVR1B1.62503571
27ZAP701.56409011
28SCYL21.55854913
29BTK1.53844411
30MAPK131.51168484
31FGFR41.50262018
32CSF1R1.49388202
33OXSR11.49188323
34MAP3K141.47493854
35SYK1.45051612
36JAK31.44527007
37DAPK21.42498546
38PINK11.41762142
39BRD41.41400954
40BLK1.40686034
41FLT31.38654337
42FES1.32421377
43CDK121.30028267
44MARK21.23890279
45MAP2K61.23708197
46ADRBK11.21750856
47PKN21.19194238
48JAK11.17693554
49RIPK41.17419710
50DYRK31.14953484
51LATS11.14154702
52PNCK1.14039641
53NTRK31.10685837
54TAOK31.10368239
55MARK11.10116449
56MAP2K71.08838130
57STK101.08835725
58MAP2K21.07685427
59LCK1.07359493
60YES11.06419653
61CAMKK21.06106732
62SIK11.05252790
63STK38L1.04252548
64CAMK41.04043356
65ITK1.03016886
66NEK21.01819974
67DYRK21.01212993
68STK161.01074368
69MAPK70.98680568
70SIK30.96689217
71IKBKB0.96302347
72HCK0.96207727
73HIPK20.94890625
74CSK0.92238909
75TGFBR20.91949651
76EPHA30.91728705
77CLK10.91462404
78BCKDK0.90799360
79LYN0.89821482
80IKBKE0.88823753
81RIPK10.87821787
82RPS6KB20.87084279
83TRIM280.86150641
84MKNK20.86036457
85RPS6KA50.83531043
86CAMK1D0.82725477
87TGFBR10.81310307
88MAPK120.81037484
89UHMK10.79511571
90DYRK1B0.79353175
91MAP2K40.77519303
92NME10.77308170
93JAK20.76976493
94PLK40.75467197
95PTK60.74889681
96TAF10.74625620
97PRKD20.73513738
98CSNK1G10.73506329
99TXK0.73437500
100CSNK1A1L0.73254514
101CSNK1G30.73008554
102TBK10.72077160
103CAMK10.71643848
104CHUK0.70739566
105DAPK10.69507722
106PRKCG0.68801868
107RPS6KA40.66696801
108CHEK20.65465927
109CDK70.64540122
110FGFR20.64331456
111MAP3K110.64229103
112MAPK40.62409140
113TRIB30.61391412
114CSNK1G20.60846821
115MATK0.59636378
116MAP3K80.58768532
117PHKG20.56598233
118PHKG10.56598233
119TTN0.56302285
120ICK0.55972206
121NTRK20.55711461
122NME20.55264967
123PRKCI0.54785228
124FGFR30.54664137
125CDC42BPA0.53890121
126INSRR0.53822042
127PRPF4B0.53154159
128PRKCE0.53022367
129PRKAA20.52993504
130RPS6KA60.52316834
131PAK30.52288048
132TEC0.51371783
133STK110.51229885
134IRAK40.50661737
135CDK40.48925521
136EPHB10.48781548
137RPS6KC10.48357589
138RPS6KL10.48357589
139MAP3K120.48131122
140CAMK1G0.48119852
141RPS6KA20.47329720
142ATR0.47138022
143SRPK10.46826889
144CDK190.46742372
145MUSK0.45790389
146PRKCH0.45069993
147VRK10.44467293
148VRK20.44280713
149ADRBK20.44086181
150PRKCQ0.43571170
151DYRK1A0.42864154
152PTK2B0.41375069
153MAPK110.41156385
154PRKCZ0.40502050
155PRKACA0.40169465
156PRKAA10.40101658
157CSNK1D0.38814870
158IRAK10.38729692
159NLK0.38549444
160MAPK150.38372351
161LRRK20.37156677
162PAK20.36847155
163CDK30.36307833
164ERBB20.35846391
165PASK0.35147328
166MAPKAPK50.35062980
167PIK3CA0.34669115
168PKN10.34632484
169CDK80.34510729
170TYRO30.33289167
171CSNK1A10.30975355
172GRK70.26586368

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.49076147
2Primary immunodeficiency_Homo sapiens_hsa053402.96312780
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85938857
4Linoleic acid metabolism_Homo sapiens_hsa005912.76580504
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.61912326
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.53032521
7Phototransduction_Homo sapiens_hsa047442.47334487
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31832268
9Nitrogen metabolism_Homo sapiens_hsa009102.30579690
10Lysine degradation_Homo sapiens_hsa003102.29123565
11Oxidative phosphorylation_Homo sapiens_hsa001902.28608423
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.27798235
13Base excision repair_Homo sapiens_hsa034102.13563079
14Osteoclast differentiation_Homo sapiens_hsa043802.13097813
15Homologous recombination_Homo sapiens_hsa034402.12393357
16Hematopoietic cell lineage_Homo sapiens_hsa046402.10725600
17ABC transporters_Homo sapiens_hsa020102.08113031
18NF-kappa B signaling pathway_Homo sapiens_hsa040642.07352388
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06445037
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06235899
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04321632
22Butanoate metabolism_Homo sapiens_hsa006502.03668003
23Sulfur relay system_Homo sapiens_hsa041222.01234618
24RNA polymerase_Homo sapiens_hsa030201.94601027
25Non-homologous end-joining_Homo sapiens_hsa034501.89434014
26T cell receptor signaling pathway_Homo sapiens_hsa046601.86354782
27Fanconi anemia pathway_Homo sapiens_hsa034601.83271606
28Leishmaniasis_Homo sapiens_hsa051401.81088649
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80078037
30Acute myeloid leukemia_Homo sapiens_hsa052211.77600273
31Measles_Homo sapiens_hsa051621.73781812
32Chronic myeloid leukemia_Homo sapiens_hsa052201.72430969
33Ether lipid metabolism_Homo sapiens_hsa005651.71935913
34Parkinsons disease_Homo sapiens_hsa050121.70112175
35Selenocompound metabolism_Homo sapiens_hsa004501.69215617
36Basal transcription factors_Homo sapiens_hsa030221.68835171
37Tryptophan metabolism_Homo sapiens_hsa003801.68745394
38DNA replication_Homo sapiens_hsa030301.52121316
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51931549
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.49393614
41Staphylococcus aureus infection_Homo sapiens_hsa051501.43545822
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41925336
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40703007
44Circadian rhythm_Homo sapiens_hsa047101.40508227
45Taste transduction_Homo sapiens_hsa047421.39557582
46Caffeine metabolism_Homo sapiens_hsa002321.37521116
47Systemic lupus erythematosus_Homo sapiens_hsa053221.34983993
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.31302680
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26021278
50Shigellosis_Homo sapiens_hsa051311.24718860
51Chemokine signaling pathway_Homo sapiens_hsa040621.22764244
52Regulation of autophagy_Homo sapiens_hsa041401.22763784
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20999438
54Hepatitis B_Homo sapiens_hsa051611.19348465
55Malaria_Homo sapiens_hsa051441.12692900
56Huntingtons disease_Homo sapiens_hsa050161.12212289
57One carbon pool by folate_Homo sapiens_hsa006701.11779671
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.11448137
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09536275
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.09376489
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05630728
62RNA degradation_Homo sapiens_hsa030181.04832082
63Arachidonic acid metabolism_Homo sapiens_hsa005901.02912927
64Herpes simplex infection_Homo sapiens_hsa051681.01705963
65Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01093727
66Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00968274
67Olfactory transduction_Homo sapiens_hsa047401.00858069
68Viral carcinogenesis_Homo sapiens_hsa052030.99911543
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99507330
70Peroxisome_Homo sapiens_hsa041460.99484024
71VEGF signaling pathway_Homo sapiens_hsa043700.99163798
72Alzheimers disease_Homo sapiens_hsa050100.95645183
73Pancreatic cancer_Homo sapiens_hsa052120.95433496
74Protein export_Homo sapiens_hsa030600.92332442
75Collecting duct acid secretion_Homo sapiens_hsa049660.91584324
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91573344
77Chemical carcinogenesis_Homo sapiens_hsa052040.90794362
78HTLV-I infection_Homo sapiens_hsa051660.89868685
79Apoptosis_Homo sapiens_hsa042100.89180286
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.87015427
81Ovarian steroidogenesis_Homo sapiens_hsa049130.86548967
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.84633811
83Antigen processing and presentation_Homo sapiens_hsa046120.83758434
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83602278
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83378553
86Fat digestion and absorption_Homo sapiens_hsa049750.83061463
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82981760
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82926900
89Influenza A_Homo sapiens_hsa051640.81666191
90Glutamatergic synapse_Homo sapiens_hsa047240.81532451
91Lysosome_Homo sapiens_hsa041420.80999719
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80673478
93Galactose metabolism_Homo sapiens_hsa000520.79591307
94Tuberculosis_Homo sapiens_hsa051520.78889041
95Platelet activation_Homo sapiens_hsa046110.78800285
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78194904
97Epstein-Barr virus infection_Homo sapiens_hsa051690.78054895
98GABAergic synapse_Homo sapiens_hsa047270.77875682
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77577735
100Non-small cell lung cancer_Homo sapiens_hsa052230.76563608
101Basal cell carcinoma_Homo sapiens_hsa052170.76548108
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76212867
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76188090
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75724569
105Pyrimidine metabolism_Homo sapiens_hsa002400.74562253
106Colorectal cancer_Homo sapiens_hsa052100.74242528
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73973917
108Small cell lung cancer_Homo sapiens_hsa052220.73915511
109Viral myocarditis_Homo sapiens_hsa054160.73660071
110Morphine addiction_Homo sapiens_hsa050320.72963585
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72504879
112Vitamin digestion and absorption_Homo sapiens_hsa049770.72390336
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71363470
114TNF signaling pathway_Homo sapiens_hsa046680.70501137
115Retinol metabolism_Homo sapiens_hsa008300.70017479
116Purine metabolism_Homo sapiens_hsa002300.69994945
117Nucleotide excision repair_Homo sapiens_hsa034200.69800019
118Complement and coagulation cascades_Homo sapiens_hsa046100.69658485
119Insulin resistance_Homo sapiens_hsa049310.69303568
120Serotonergic synapse_Homo sapiens_hsa047260.68009161
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67303654
122Toxoplasmosis_Homo sapiens_hsa051450.67107971
123Cardiac muscle contraction_Homo sapiens_hsa042600.66638513
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65424386
125Type II diabetes mellitus_Homo sapiens_hsa049300.63869508
126Metabolic pathways_Homo sapiens_hsa011000.63700693
127Circadian entrainment_Homo sapiens_hsa047130.63387622
128Alcoholism_Homo sapiens_hsa050340.61075502
129Inositol phosphate metabolism_Homo sapiens_hsa005620.60426155
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60171227
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60138995
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.59838740
133Calcium signaling pathway_Homo sapiens_hsa040200.57796217
134Sulfur metabolism_Homo sapiens_hsa009200.57514890
135Other glycan degradation_Homo sapiens_hsa005110.57392375
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56843873
137Steroid biosynthesis_Homo sapiens_hsa001000.56391410
138MAPK signaling pathway_Homo sapiens_hsa040100.55742387
139Ribosome_Homo sapiens_hsa030100.55350689
140Insulin secretion_Homo sapiens_hsa049110.54946512
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54082070
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.53117557
143Glycerolipid metabolism_Homo sapiens_hsa005610.52902603
144Prolactin signaling pathway_Homo sapiens_hsa049170.52557164
145Fructose and mannose metabolism_Homo sapiens_hsa000510.52284463
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51852675
147Spliceosome_Homo sapiens_hsa030400.51152885
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50667683
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.50166653
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49723931
151Hedgehog signaling pathway_Homo sapiens_hsa043400.49714977
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.49494455
153Endometrial cancer_Homo sapiens_hsa052130.48792349
154mTOR signaling pathway_Homo sapiens_hsa041500.48479408
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48187725
156Propanoate metabolism_Homo sapiens_hsa006400.47819358
157Notch signaling pathway_Homo sapiens_hsa043300.45564364
158Cyanoamino acid metabolism_Homo sapiens_hsa004600.44335085
159Histidine metabolism_Homo sapiens_hsa003400.43361987
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.42813728
161Nicotine addiction_Homo sapiens_hsa050330.42665166
162Insulin signaling pathway_Homo sapiens_hsa049100.42355882
163Oxytocin signaling pathway_Homo sapiens_hsa049210.39610558
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39356649
165MicroRNAs in cancer_Homo sapiens_hsa052060.39007045
166Hepatitis C_Homo sapiens_hsa051600.38392452
167Fatty acid biosynthesis_Homo sapiens_hsa000610.38336413
168Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37471358
169Mismatch repair_Homo sapiens_hsa034300.37111076
170Glioma_Homo sapiens_hsa052140.36941552
171p53 signaling pathway_Homo sapiens_hsa041150.36284328
172Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36134588
173Sphingolipid metabolism_Homo sapiens_hsa006000.35204214
174Salivary secretion_Homo sapiens_hsa049700.35070827
175Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34519312
176Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32310148
177Asthma_Homo sapiens_hsa053100.32049909
178Dopaminergic synapse_Homo sapiens_hsa047280.31154716
179Cholinergic synapse_Homo sapiens_hsa047250.30552287
180Cocaine addiction_Homo sapiens_hsa050300.29039295

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