ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	7.45120364
2	behavioral response to ethanol (GO:0048149)	5.58995964
3	piRNA metabolic process (GO:0034587)	4.94121425
4	opioid receptor signaling pathway (GO:0038003)	4.76722009
5	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.69607427
6	negative regulation of cAMP-mediated signaling (GO:0043951)	4.64436097
7	behavioral response to nicotine (GO:0035095)	4.24697136
8	regulation of protein glycosylation (GO:0060049)	4.21635951
9	adult feeding behavior (GO:0008343)	3.93034895
10	fucose catabolic process (GO:0019317)	3.73906226
11	L-fucose metabolic process (GO:0042354)	3.73906226
12	L-fucose catabolic process (GO:0042355)	3.73906226
13	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.65788933
14	neuronal action potential (GO:0019228)	3.65318251
15	response to pheromone (GO:0019236)	3.64862636
16	sphingoid metabolic process (GO:0046519)	3.57313172
17	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.57146409
18	regulation of acrosome reaction (GO:0060046)	3.54587101
19	protein K11-linked deubiquitination (GO:0035871)	3.52946583
20	positive regulation of cAMP-mediated signaling (GO:0043950)	3.50798019
21	sphingosine metabolic process (GO:0006670)	3.49485766
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47996776
23	membrane depolarization during action potential (GO:0086010)	3.44847237
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43414409
25	gamma-aminobutyric acid transport (GO:0015812)	3.35649070
26	protein polyglutamylation (GO:0018095)	3.28696802
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.27491574
28	detection of light stimulus involved in visual perception (GO:0050908)	3.27491574
29	diol metabolic process (GO:0034311)	3.26060109
30	synaptic transmission, glutamatergic (GO:0035249)	3.24832563
31	indolalkylamine metabolic process (GO:0006586)	3.22010797
32	transmission of nerve impulse (GO:0019226)	3.19091835
33	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.16693985
34	regulation of glutamate receptor signaling pathway (GO:1900449)	3.14938946
35	epithelial cilium movement (GO:0003351)	3.10350165
36	protein localization to synapse (GO:0035418)	3.10277943
37	retinal cone cell development (GO:0046549)	3.05794189
38	ether lipid metabolic process (GO:0046485)	3.04695758
39	cellular ketone body metabolic process (GO:0046950)	3.03289330
40	indole-containing compound catabolic process (GO:0042436)	3.00286693
41	indolalkylamine catabolic process (GO:0046218)	3.00286693
42	tryptophan catabolic process (GO:0006569)	3.00286693
43	sperm motility (GO:0030317)	2.97376467
44	primary amino compound metabolic process (GO:1901160)	2.97017650
45	C4-dicarboxylate transport (GO:0015740)	2.97005321
46	cAMP catabolic process (GO:0006198)	2.93158533
47	startle response (GO:0001964)	2.91936181
48	indole-containing compound metabolic process (GO:0042430)	2.90965971
49	cilium morphogenesis (GO:0060271)	2.90235251
50	photoreceptor cell maintenance (GO:0045494)	2.88467102
51	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.86389648
52	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.85400046
53	serotonin metabolic process (GO:0042428)	2.84667698
54	neural tube formation (GO:0001841)	2.82897391
55	DNA methylation involved in gamete generation (GO:0043046)	2.82799629
56	regulation of meiosis I (GO:0060631)	2.80298732
57	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.80161524
58	reflex (GO:0060004)	2.79587214
59	cornea development in camera-type eye (GO:0061303)	2.78597021
60	pyrimidine dimer repair (GO:0006290)	2.78432233
61	glycerophospholipid catabolic process (GO:0046475)	2.77994577
62	cilium or flagellum-dependent cell motility (GO:0001539)	2.77621738
63	replication fork processing (GO:0031297)	2.77144115
64	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75777951
65	rhodopsin mediated signaling pathway (GO:0016056)	2.75737895
66	ncRNA catabolic process (GO:0034661)	2.75057020
67	negative regulation of mast cell activation (GO:0033004)	2.72891642
68	presynaptic membrane assembly (GO:0097105)	2.72758697
69	postsynaptic membrane organization (GO:0001941)	2.70490232
70	neuron-neuron synaptic transmission (GO:0007270)	2.70211084
71	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.68566994
72	thyroid hormone metabolic process (GO:0042403)	2.68447150
73	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.68324392
74	neuronal action potential propagation (GO:0019227)	2.67145191
75	cyclic nucleotide catabolic process (GO:0009214)	2.66959063
76	ketone body metabolic process (GO:1902224)	2.66670473
77	glutamate receptor signaling pathway (GO:0007215)	2.66170566
78	establishment of protein localization to Golgi (GO:0072600)	2.64705429
79	sulfation (GO:0051923)	2.64169459
80	glycosphingolipid biosynthetic process (GO:0006688)	2.63761707
81	kynurenine metabolic process (GO:0070189)	2.61263597
82	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.61226197
83	negative regulation of adenylate cyclase activity (GO:0007194)	2.58926612
84	water-soluble vitamin biosynthetic process (GO:0042364)	2.57158744
85	positive regulation of fatty acid transport (GO:2000193)	2.56944555
86	proline transport (GO:0015824)	2.55971148
87	male meiosis (GO:0007140)	2.54884241
88	axoneme assembly (GO:0035082)	2.54661155
89	tryptophan metabolic process (GO:0006568)	2.53933049
90	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.53729716
91	spermatid development (GO:0007286)	2.52575087
92	centriole replication (GO:0007099)	2.51857522
93	acrosome reaction (GO:0007340)	2.51521246
94	regulation of neurotransmitter uptake (GO:0051580)	2.51011766
95	axon ensheathment in central nervous system (GO:0032291)	2.49769412
96	central nervous system myelination (GO:0022010)	2.49769412
97	cilium movement (GO:0003341)	2.49382786
98	action potential (GO:0001508)	2.48634716
99	nonmotile primary cilium assembly (GO:0035058)	2.47572571
100	pyrimidine nucleobase catabolic process (GO:0006208)	2.47400509

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.55296710
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.54904285
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.18886407
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16207307
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.74609126
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73053132
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.68999645
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.59394535
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44752063
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42579147
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38817944
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14531262
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08000926
14	P300_19829295_ChIP-Seq_ESCs_Human	2.05734701
15	FUS_26573619_Chip-Seq_HEK293_Human	2.05618419
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.02643579
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99436480
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98550851
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.98550851
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.95307660
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.90002769
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85941329
23	EWS_26573619_Chip-Seq_HEK293_Human	1.84821518
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81450477
25	STAT3_23295773_ChIP-Seq_U87_Human	1.78741165
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77433873
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.75824155
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75169225
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71380959
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70396086
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.69080220
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69080220
33	TCF4_23295773_ChIP-Seq_U87_Human	1.65175773
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64765209
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.60884797
36	AR_25329375_ChIP-Seq_VCAP_Human	1.60430897
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57971225
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57171742
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.56863031
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55889552
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.55567303
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.50727392
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49749928
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49398788
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42677066
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42576300
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41996060
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37745593
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36887027
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36487375
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36487375
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36481403
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36479905
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35490408
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34873811
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34596938
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34039910
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.32425538
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30333477
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30251784
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29668006
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28527470
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.27200679
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.26010689
65	RXR_22108803_ChIP-Seq_LS180_Human	1.24706964
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24337190
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24164073
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.22894968
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20802323
70	DROSHA_22980978_ChIP-Seq_HELA_Human	1.20700053
71	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.20206312
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19872206
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19370450
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17964540
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17414314
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14255125
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12533106
78	TP53_16413492_ChIP-PET_HCT116_Human	1.11998692
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10590928
80	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09952404
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09694874
82	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09589136
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09406638
84	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09116136
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08787594
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05639682
87	JUN_21703547_ChIP-Seq_K562_Human	1.05626755
88	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05543716
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05037100
90	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04172516
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03229353
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02865206
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00232753
94	KDM2B_26808549_Chip-Seq_REH_Human	0.99806400
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98262989
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.98208617
97	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.98140200
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97347276
99	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.96232546
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96228638

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	3.72837448
2	MP0000569_abnormal_digit_pigmentation	3.49065040
3	MP0003880_abnormal_central_pattern	2.87537170
4	MP0005551_abnormal_eye_electrophysiolog	2.80548340
5	MP0002876_abnormal_thyroid_physiology	2.75631333
6	MP0009046_muscle_twitch	2.63961875
7	MP0009745_abnormal_behavioral_response	2.52191960
8	MP0001501_abnormal_sleep_pattern	2.46164094
9	MP0005646_abnormal_pituitary_gland	2.44958134
10	MP0008877_abnormal_DNA_methylation	2.44115211
11	MP0001486_abnormal_startle_reflex	2.33233863
12	MP0002736_abnormal_nociception_after	2.28219394
13	MP0002272_abnormal_nervous_system	2.22986560
14	MP0009780_abnormal_chondrocyte_physiolo	2.04306675
15	MP0003195_calcinosis	1.96790166
16	MP0002064_seizures	1.95022119
17	MP0005645_abnormal_hypothalamus_physiol	1.93762778
18	MP0003646_muscle_fatigue	1.91718851
19	MP0003635_abnormal_synaptic_transmissio	1.85616790
20	MP0004043_abnormal_pH_regulation	1.85417613
21	MP0002735_abnormal_chemical_nociception	1.84304658
22	MP0002733_abnormal_thermal_nociception	1.82936573
23	MP0004147_increased_porphyrin_level	1.78581314
24	MP0003787_abnormal_imprinting	1.78419772
25	MP0001986_abnormal_taste_sensitivity	1.77358251
26	MP0000427_abnormal_hair_cycle	1.74134810
27	MP0006072_abnormal_retinal_apoptosis	1.71915507
28	MP0002102_abnormal_ear_morphology	1.71746086
29	MP0004859_abnormal_synaptic_plasticity	1.69827360
30	MP0005253_abnormal_eye_physiology	1.65147889
31	MP0002572_abnormal_emotion/affect_behav	1.64849927
32	MP0001970_abnormal_pain_threshold	1.60551485
33	MP0002063_abnormal_learning/memory/cond	1.55961770
34	MP0002067_abnormal_sensory_capabilities	1.53162220
35	MP0004742_abnormal_vestibular_system	1.52723275
36	MP0003136_yellow_coat_color	1.49859701
37	MP0008872_abnormal_physiological_respon	1.49201671
38	MP0002837_dystrophic_cardiac_calcinosis	1.48803661
39	MP0006276_abnormal_autonomic_nervous	1.48515006
40	MP0004142_abnormal_muscle_tone	1.46692328
41	MP0004885_abnormal_endolymph	1.46083345
42	MP0002638_abnormal_pupillary_reflex	1.44962159
43	MP0001485_abnormal_pinna_reflex	1.43550720
44	MP0005377_hearing/vestibular/ear_phenot	1.43007587
45	MP0003878_abnormal_ear_physiology	1.43007587
46	MP0000778_abnormal_nervous_system	1.38455429
47	MP0005423_abnormal_somatic_nervous	1.35049944
48	MP0002557_abnormal_social/conspecific_i	1.28242753
49	MP0004924_abnormal_behavior	1.27389931
50	MP0005386_behavior/neurological_phenoty	1.27389931
51	MP0003045_fibrosis	1.23439050
52	MP0005410_abnormal_fertilization	1.23134723
53	MP0003879_abnormal_hair_cell	1.21711959
54	MP0001984_abnormal_olfaction	1.20327393
55	MP0000631_abnormal_neuroendocrine_gland	1.18991083
56	MP0002734_abnormal_mechanical_nocicepti	1.17880197
57	MP0003633_abnormal_nervous_system	1.17816714
58	MP0002095_abnormal_skin_pigmentation	1.13776700
59	MP0005195_abnormal_posterior_eye	1.11908410
60	MP0002653_abnormal_ependyma_morphology	1.09246824
61	MP0002229_neurodegeneration	1.09245702
62	MP0001529_abnormal_vocalization	1.08368563
63	MP0003698_abnormal_male_reproductive	1.08114960
64	MP0008875_abnormal_xenobiotic_pharmacok	1.07769184
65	MP0008057_abnormal_DNA_replication	1.06127349
66	MP0001963_abnormal_hearing_physiology	1.04516685
67	MP0005174_abnormal_tail_pigmentation	1.03359273
68	MP0002752_abnormal_somatic_nervous	0.99993703
69	MP0004270_analgesia	0.99345540
70	MP0000015_abnormal_ear_pigmentation	0.99271809
71	MP0009764_decreased_sensitivity_to	0.98866591
72	MP0009278_abnormal_bone_marrow	0.98518130
73	MP0002234_abnormal_pharynx_morphology	0.95562515
74	MP0006292_abnormal_olfactory_placode	0.94766272
75	MP0000383_abnormal_hair_follicle	0.94408515
76	MP0002882_abnormal_neuron_morphology	0.94390677
77	MP0001929_abnormal_gametogenesis	0.93522951
78	MP0005503_abnormal_tendon_morphology	0.92865572
79	MP0001664_abnormal_digestion	0.92150038
80	MP0006035_abnormal_mitochondrial_morpho	0.91233115
81	MP0005670_abnormal_white_adipose	0.86233068
82	MP0003631_nervous_system_phenotype	0.84823671
83	MP0000230_abnormal_systemic_arterial	0.84397234
84	MP0001905_abnormal_dopamine_level	0.83452776
85	MP0000955_abnormal_spinal_cord	0.82997243
86	MP0004133_heterotaxia	0.82562530
87	MP0000026_abnormal_inner_ear	0.81949058
88	MP0002184_abnormal_innervation	0.81496543
89	MP0003937_abnormal_limbs/digits/tail_de	0.81268881
90	MP0001324_abnormal_eye_pigmentation	0.80844586
91	MP0002938_white_spotting	0.80262346
92	MP0000647_abnormal_sebaceous_gland	0.78627998
93	MP0001502_abnormal_circadian_rhythm	0.76334462
94	MP0005187_abnormal_penis_morphology	0.74965890
95	MP0000049_abnormal_middle_ear	0.74317603
96	MP0002210_abnormal_sex_determination	0.73723812
97	MP0004085_abnormal_heartbeat	0.73181935
98	MP0005171_absent_coat_pigmentation	0.71679048
99	MP0002928_abnormal_bile_duct	0.71421081
100	MP0005389_reproductive_system_phenotype	0.70869799

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	5.55628542
2	Focal motor seizures (HP:0011153)	4.41301379
3	Hyperventilation (HP:0002883)	4.03734747
4	Pancreatic cysts (HP:0001737)	4.00799166
5	Pancreatic fibrosis (HP:0100732)	3.59578125
6	Congenital stationary night blindness (HP:0007642)	3.53695550
7	Gaze-evoked nystagmus (HP:0000640)	3.53462459
8	Molar tooth sign on MRI (HP:0002419)	3.53306604
9	Abnormality of midbrain morphology (HP:0002418)	3.53306604
10	Intestinal atresia (HP:0011100)	3.42996084
11	True hermaphroditism (HP:0010459)	3.42618616
12	Volvulus (HP:0002580)	3.41978670
13	Type II lissencephaly (HP:0007260)	3.29099820
14	Nephronophthisis (HP:0000090)	3.23730582
15	Attenuation of retinal blood vessels (HP:0007843)	3.16289202
16	Focal seizures (HP:0007359)	3.08012124
17	Tubular atrophy (HP:0000092)	3.03633233
18	Inability to walk (HP:0002540)	2.99624461
19	Broad-based gait (HP:0002136)	2.95514266
20	Abnormality of the renal medulla (HP:0100957)	2.94500459
21	Keratoconus (HP:0000563)	2.93874232
22	Increased corneal curvature (HP:0100692)	2.93874232
23	Abnormality of the renal cortex (HP:0011035)	2.91226573
24	Large for gestational age (HP:0001520)	2.88906046
25	Chronic hepatic failure (HP:0100626)	2.83646659
26	Febrile seizures (HP:0002373)	2.81556215
27	Pendular nystagmus (HP:0012043)	2.81254298
28	Dialeptic seizures (HP:0011146)	2.77780246
29	Progressive inability to walk (HP:0002505)	2.76998458
30	Medial flaring of the eyebrow (HP:0010747)	2.74569282
31	Lissencephaly (HP:0001339)	2.64017787
32	Optic nerve hypoplasia (HP:0000609)	2.58866037
33	Abolished electroretinogram (ERG) (HP:0000550)	2.55335044
34	Progressive cerebellar ataxia (HP:0002073)	2.54250964
35	Cerebellar dysplasia (HP:0007033)	2.52365559
36	Agitation (HP:0000713)	2.52090529
37	Abnormality of alanine metabolism (HP:0010916)	2.35659019
38	Hyperalaninemia (HP:0003348)	2.35659019
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35659019
40	Absent speech (HP:0001344)	2.35597221
41	Genetic anticipation (HP:0003743)	2.34579330
42	Atonic seizures (HP:0010819)	2.33452855
43	Gait imbalance (HP:0002141)	2.32280107
44	Polydipsia (HP:0001959)	2.30746319
45	Abnormal drinking behavior (HP:0030082)	2.30746319
46	Cystic liver disease (HP:0006706)	2.30462695
47	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.28882998
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.28816507
49	Abnormality of macular pigmentation (HP:0008002)	2.27412939
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.26305617
51	Stomach cancer (HP:0012126)	2.25643767
52	Renal cortical cysts (HP:0000803)	2.25294380
53	Protruding tongue (HP:0010808)	2.24641773
54	Decreased central vision (HP:0007663)	2.19214338
55	Congenital primary aphakia (HP:0007707)	2.15761170
56	Hemiparesis (HP:0001269)	2.15383272
57	Gastrointestinal atresia (HP:0002589)	2.13041810
58	Pancreatic islet-cell hyperplasia (HP:0004510)	2.12779312
59	Fair hair (HP:0002286)	2.09365606
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.08129700
61	Generalized tonic-clonic seizures (HP:0002069)	2.08052359
62	Sclerocornea (HP:0000647)	2.07386247
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06397576
64	Epileptic encephalopathy (HP:0200134)	2.03490901
65	Abnormality of the aortic arch (HP:0012303)	2.01609420
66	Abnormality of the labia minora (HP:0012880)	2.01335732
67	Chorioretinal atrophy (HP:0000533)	2.01248939
68	Abnormality of the ileum (HP:0001549)	2.01172072
69	Retinal dysplasia (HP:0007973)	1.99190166
70	Genital tract atresia (HP:0001827)	1.97904470
71	Nephrogenic diabetes insipidus (HP:0009806)	1.97412267
72	Pachygyria (HP:0001302)	1.96633298
73	Thickened helices (HP:0000391)	1.92761017
74	Clumsiness (HP:0002312)	1.91773558
75	Drooling (HP:0002307)	1.90882991
76	Absence seizures (HP:0002121)	1.90860803
77	Severe visual impairment (HP:0001141)	1.90482916
78	Mesangial abnormality (HP:0001966)	1.89443127
79	Postaxial foot polydactyly (HP:0001830)	1.88454555
80	Vaginal atresia (HP:0000148)	1.85978750
81	Tented upper lip vermilion (HP:0010804)	1.85030351
82	Male pseudohermaphroditism (HP:0000037)	1.84022392
83	Congenital hepatic fibrosis (HP:0002612)	1.83737869
84	Amelogenesis imperfecta (HP:0000705)	1.82094105
85	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80128825
86	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79738035
87	Absent/shortened dynein arms (HP:0200106)	1.79738035
88	Polyuria (HP:0000103)	1.79023761
89	Oligodontia (HP:0000677)	1.78372202
90	Poor coordination (HP:0002370)	1.78216132
91	Furrowed tongue (HP:0000221)	1.77335998
92	Impulsivity (HP:0100710)	1.74399995
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.72974362
94	Anencephaly (HP:0002323)	1.70344727
95	Broad alveolar ridges (HP:0000187)	1.68166759
96	Excessive salivation (HP:0003781)	1.68151264
97	Oligodactyly (hands) (HP:0001180)	1.65981374
98	Status epilepticus (HP:0002133)	1.64433546
99	Decreased circulating renin level (HP:0003351)	1.63793235
100	Long nose (HP:0003189)	1.62242204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.66572671
2	ADRBK2	5.11135092
3	BMPR1B	2.90673631
4	PINK1	2.79163866
5	CASK	2.75670793
6	ACVR1B	2.43782534
7	WNK3	2.37957242
8	PNCK	2.25627114
9	MAP4K2	2.16746089
10	MARK1	2.15341992
11	MAPK13	2.10570953
12	ZAK	1.93413023
13	TAOK3	1.92275986
14	GRK1	1.89248836
15	MAP3K4	1.63178108
16	NUAK1	1.53425780
17	ADRBK1	1.53379381
18	PLK2	1.50087416
19	STK38L	1.48564252
20	PRKCG	1.43747307
21	PLK4	1.41463184
22	NTRK3	1.37551200
23	NTRK2	1.37471336
24	TNIK	1.23520697
25	STK39	1.23200295
26	OXSR1	1.22866148
27	WNK4	1.21726818
28	PRKCE	1.21323817
29	INSRR	1.16734155
30	CSNK1G2	1.07673193
31	TGFBR1	1.00285043
32	CSNK1A1L	0.98912079
33	MAP2K7	0.98858385
34	TLK1	0.98146779
35	CAMK1G	0.95202272
36	CAMK2A	0.94920867
37	PAK3	0.93034914
38	CSNK1G3	0.91250195
39	FGFR2	0.90299781
40	IRAK1	0.87395134
41	BCR	0.84920492
42	CSNK1G1	0.84589159
43	MAPKAPK5	0.83019252
44	DYRK2	0.80296327
45	TXK	0.80265973
46	EPHA4	0.80025166
47	DAPK2	0.76154194
48	EIF2AK3	0.74566030
49	STK3	0.74428443
50	TRIM28	0.74423079
51	PKN1	0.70832378
52	STK38	0.70559268
53	MKNK2	0.69567294
54	WEE1	0.67424878
55	CAMK1	0.66890930
56	PTK2B	0.66050632
57	CCNB1	0.65863993
58	CAMKK2	0.64180452
59	CAMK4	0.59259792
60	PIK3CA	0.58394114
61	TEC	0.56296541
62	TYRO3	0.56238812
63	BRSK2	0.55776909
64	PHKG2	0.54106654
65	PHKG1	0.54106654
66	MAPKAPK3	0.52918262
67	SGK1	0.52320189
68	CSNK1A1	0.50297115
69	ERBB3	0.48991765
70	PRKACA	0.47285499
71	CSNK1D	0.45535454
72	SIK2	0.43790011
73	CAMK2B	0.42608828
74	DYRK3	0.42240178
75	PRKCZ	0.41051326
76	DYRK1A	0.40816106
77	PRKG1	0.40258903
78	CAMK1D	0.40244866
79	ERBB2	0.38994765
80	TIE1	0.38795501
81	PRKD3	0.38292161
82	PRKAA1	0.37470228
83	CHEK2	0.37443688
84	GRK5	0.36534596
85	STK11	0.34784126
86	PRKCB	0.34595710
87	PRKCA	0.34353839
88	RPS6KA3	0.34248732
89	PRKAA2	0.34106000
90	SGK2	0.32894004
91	PRKACB	0.32621846
92	LATS1	0.30918948
93	CSNK1E	0.30044036
94	PRKCQ	0.29601447
95	CDK5	0.29590531
96	ATM	0.28827068
97	GRK7	0.28680597
98	RPS6KA5	0.27970971
99	CDK3	0.27283740
100	PRKCI	0.27176601

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.62980154
2	Phototransduction_Homo sapiens_hsa04744	3.05426039
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.90728964
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47364701
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.43688328
6	Morphine addiction_Homo sapiens_hsa05032	2.41856947
7	Butanoate metabolism_Homo sapiens_hsa00650	2.40543089
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.32746704
9	Olfactory transduction_Homo sapiens_hsa04740	2.26630126
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.26172457
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20743129
12	Taste transduction_Homo sapiens_hsa04742	2.20022162
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.12582312
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.11197071
15	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.02969241
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.99036703
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98602357
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89192232
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.72117947
20	ABC transporters_Homo sapiens_hsa02010	1.67011952
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.66649245
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.66128803
23	GABAergic synapse_Homo sapiens_hsa04727	1.65488091
24	Circadian entrainment_Homo sapiens_hsa04713	1.64717470
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63605970
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.52270850
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50639744
28	Homologous recombination_Homo sapiens_hsa03440	1.48873286
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.43156653
30	Basal transcription factors_Homo sapiens_hsa03022	1.35816908
31	Insulin secretion_Homo sapiens_hsa04911	1.34101694
32	Propanoate metabolism_Homo sapiens_hsa00640	1.28875704
33	Salivary secretion_Homo sapiens_hsa04970	1.26769381
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23721296
35	Serotonergic synapse_Homo sapiens_hsa04726	1.22233175
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14170689
37	Sphingolipid metabolism_Homo sapiens_hsa00600	1.10589937
38	Calcium signaling pathway_Homo sapiens_hsa04020	1.05032896
39	Caffeine metabolism_Homo sapiens_hsa00232	1.04815789
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02072523
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99391758
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98366474
43	Dopaminergic synapse_Homo sapiens_hsa04728	0.97697005
44	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95001775
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.94233387
46	Long-term depression_Homo sapiens_hsa04730	0.92109883
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90109717
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89435139
49	Amphetamine addiction_Homo sapiens_hsa05031	0.88541199
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87978277
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.85751902
52	Circadian rhythm_Homo sapiens_hsa04710	0.84599153
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82463323
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82198398
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82153345
56	Peroxisome_Homo sapiens_hsa04146	0.81531338
57	Regulation of autophagy_Homo sapiens_hsa04140	0.77605804
58	Retinol metabolism_Homo sapiens_hsa00830	0.77316343
59	RNA degradation_Homo sapiens_hsa03018	0.76801177
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75298876
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.74463336
62	Gastric acid secretion_Homo sapiens_hsa04971	0.70898528
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70770191
64	Cocaine addiction_Homo sapiens_hsa05030	0.70214942
65	Cholinergic synapse_Homo sapiens_hsa04725	0.66862620
66	Histidine metabolism_Homo sapiens_hsa00340	0.66856746
67	One carbon pool by folate_Homo sapiens_hsa00670	0.64945763
68	Protein export_Homo sapiens_hsa03060	0.64680773
69	Mineral absorption_Homo sapiens_hsa04978	0.58912531
70	RNA polymerase_Homo sapiens_hsa03020	0.56740640
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56622545
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.55910172
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51871110
74	Renin secretion_Homo sapiens_hsa04924	0.50889381
75	Purine metabolism_Homo sapiens_hsa00230	0.49723721
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.48428913
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47225343
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46340123
79	Pancreatic secretion_Homo sapiens_hsa04972	0.44125304
80	Fatty acid degradation_Homo sapiens_hsa00071	0.43424469
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43364769
82	Metabolic pathways_Homo sapiens_hsa01100	0.41896331
83	Parkinsons disease_Homo sapiens_hsa05012	0.41214480
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41178208
85	Axon guidance_Homo sapiens_hsa04360	0.36859254
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36516611
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35592533
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34181558
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33519315
90	Huntingtons disease_Homo sapiens_hsa05016	0.32174010
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32099164
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.29120588
93	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.28442667
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28189255
95	Alzheimers disease_Homo sapiens_hsa05010	0.27710247
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.24952706
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24465709
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.23136936
99	Estrogen signaling pathway_Homo sapiens_hsa04915	0.19536640
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.18820194

CCDC144CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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