ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA methylation involved in gamete generation (GO:0043046)	4.05265064
2	microtubule polymerization or depolymerization (GO:0031109)	3.91548220
3	response to pheromone (GO:0019236)	3.88927145
4	pre-miRNA processing (GO:0031054)	3.69889444
5	resolution of meiotic recombination intermediates (GO:0000712)	3.67900845
6	regulation of centriole replication (GO:0046599)	3.66838198
7	indole-containing compound catabolic process (GO:0042436)	3.61230095
8	indolalkylamine catabolic process (GO:0046218)	3.61230095
9	tryptophan catabolic process (GO:0006569)	3.61230095
10	meiotic chromosome segregation (GO:0045132)	3.46488981
11	piRNA metabolic process (GO:0034587)	3.43582441
12	synapsis (GO:0007129)	3.41308799
13	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.30702310
14	monoubiquitinated protein deubiquitination (GO:0035520)	3.30521367
15	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.30325959
16	indolalkylamine metabolic process (GO:0006586)	3.21776996
17	sensory perception of smell (GO:0007608)	3.19228971
18	regulation of hippo signaling (GO:0035330)	3.16593508
19	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.12814310
20	regulation of centrosome cycle (GO:0046605)	3.01913892
21	DNA replication checkpoint (GO:0000076)	2.96779934
22	tryptophan metabolic process (GO:0006568)	2.96484132
23	kynurenine metabolic process (GO:0070189)	2.96372489
24	regulation of centrosome duplication (GO:0010824)	2.95973417
25	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.94755368
26	cilium or flagellum-dependent cell motility (GO:0001539)	2.93403770
27	histone H2A acetylation (GO:0043968)	2.91908258
28	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.91823037
29	sister chromatid segregation (GO:0000819)	2.88670254
30	microtubule anchoring (GO:0034453)	2.87718014
31	gamma-aminobutyric acid transport (GO:0015812)	2.86565199
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.86495283
33	ncRNA catabolic process (GO:0034661)	2.86462278
34	proline transport (GO:0015824)	2.86179134
35	photoreceptor cell maintenance (GO:0045494)	2.85882920
36	righting reflex (GO:0060013)	2.84564576
37	mitotic sister chromatid segregation (GO:0000070)	2.81224026
38	reflex (GO:0060004)	2.76993261
39	neural tube formation (GO:0001841)	2.76890042
40	double-strand break repair via homologous recombination (GO:0000724)	2.75656285
41	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.75377176
42	gene silencing by RNA (GO:0031047)	2.74679824
43	recombinational repair (GO:0000725)	2.73609195
44	nuclear pore complex assembly (GO:0051292)	2.71780501
45	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.71610527
46	pteridine-containing compound biosynthetic process (GO:0042559)	2.70805801
47	DNA double-strand break processing (GO:0000729)	2.68668414
48	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.63775529
49	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.63775529
50	protein localization to synapse (GO:0035418)	2.63413441
51	nuclear pore organization (GO:0006999)	2.62615788
52	histone mRNA catabolic process (GO:0071044)	2.61302541
53	ribonucleoprotein complex disassembly (GO:0032988)	2.60929479
54	centriole replication (GO:0007099)	2.60055489
55	male meiosis (GO:0007140)	2.59618809
56	DNA damage response, detection of DNA damage (GO:0042769)	2.57613322
57	detection of light stimulus involved in visual perception (GO:0050908)	2.55602034
58	detection of light stimulus involved in sensory perception (GO:0050962)	2.55602034
59	microtubule depolymerization (GO:0007019)	2.55049096
60	protein polyglutamylation (GO:0018095)	2.54931188
61	replication fork processing (GO:0031297)	2.53633077
62	cellular ketone body metabolic process (GO:0046950)	2.52830277
63	aspartate family amino acid biosynthetic process (GO:0009067)	2.52293765
64	L-methionine salvage (GO:0071267)	2.51574132
65	L-methionine biosynthetic process (GO:0071265)	2.51574132
66	amino acid salvage (GO:0043102)	2.51574132
67	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.50262510
68	dicarboxylic acid catabolic process (GO:0043649)	2.50215685
69	amine catabolic process (GO:0009310)	2.47950235
70	cellular biogenic amine catabolic process (GO:0042402)	2.47950235
71	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.45806006
72	DNA replication initiation (GO:0006270)	2.45750573
73	regulation of response to osmotic stress (GO:0047484)	2.45730997
74	postreplication repair (GO:0006301)	2.45470192
75	negative regulation of DNA recombination (GO:0045910)	2.45418967
76	binding of sperm to zona pellucida (GO:0007339)	2.45413647
77	glyoxylate metabolic process (GO:0046487)	2.45388295
78	tachykinin receptor signaling pathway (GO:0007217)	2.43700391
79	tRNA aminoacylation for protein translation (GO:0006418)	2.42394499
80	sperm-egg recognition (GO:0035036)	2.41979520
81	relaxation of smooth muscle (GO:0044557)	2.41708901
82	protein K11-linked deubiquitination (GO:0035871)	2.39538965
83	protein K6-linked ubiquitination (GO:0085020)	2.38334324
84	nonmotile primary cilium assembly (GO:0035058)	2.36221659
85	behavioral response to nicotine (GO:0035095)	2.35889972
86	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.35714213
87	cholesterol biosynthetic process (GO:0006695)	2.34566563
88	protein localization to cilium (GO:0061512)	2.33852490
89	microtubule nucleation (GO:0007020)	2.33367733
90	chromosome segregation (GO:0007059)	2.32698291
91	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.32653892
92	methionine biosynthetic process (GO:0009086)	2.32337208
93	tRNA aminoacylation (GO:0043039)	2.31671024
94	amino acid activation (GO:0043038)	2.31671024
95	hyperosmotic salinity response (GO:0042538)	2.31240691
96	reciprocal DNA recombination (GO:0035825)	2.31078326
97	reciprocal meiotic recombination (GO:0007131)	2.31078326
98	sulfur amino acid biosynthetic process (GO:0000097)	2.30003689
99	cilium morphogenesis (GO:0060271)	2.29844521
100	neuronal action potential (GO:0019228)	2.28494914

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.40863123
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.19216367
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.83410319
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.37601969
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.81807661
6	VDR_22108803_ChIP-Seq_LS180_Human	2.77516774
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.74775100
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.69780334
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54802914
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.47619157
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.44880254
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.33810412
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30313261
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22379126
15	EWS_26573619_Chip-Seq_HEK293_Human	2.18783284
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.16642333
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.08207165
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.07214073
19	FUS_26573619_Chip-Seq_HEK293_Human	1.98450091
20	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.97151599
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92642790
22	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.89385062
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86106391
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.82936521
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.81518808
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77228304
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.77001039
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72080127
29	P300_19829295_ChIP-Seq_ESCs_Human	1.65472141
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.64942642
31	STAT3_23295773_ChIP-Seq_U87_Human	1.64552663
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57488114
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54659454
34	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.50947794
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50874121
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50705745
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50267116
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48363890
39	* TP53_22573176_ChIP-Seq_HFKS_Human	1.47985910
40	TCF4_23295773_ChIP-Seq_U87_Human	1.42578775
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.40266709
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40266709
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40089958
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40089958
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.32917139
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.31041758
47	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.30786388
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30712227
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27996580
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.27798836
51	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.25946988
52	TP53_16413492_ChIP-PET_HCT116_Human	1.25524476
53	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.25060723
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.24887946
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20102532
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19116904
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18935926
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17180135
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16121442
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15438786
61	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.15399830
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15256098
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14183533
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11276216
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.11177026
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10573806
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10050875
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09668988
69	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.09590816
70	JUN_21703547_ChIP-Seq_K562_Human	1.08719305
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.07224254
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06834880
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04956714
74	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.04722148
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04457728
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.04367349
77	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00944049
78	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00722513
79	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00248700
80	AR_25329375_ChIP-Seq_VCAP_Human	0.98844583
81	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97904006
82	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97694601
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96118866
84	NCOR_22424771_ChIP-Seq_293T_Human	0.96047180
85	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96011636
86	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.95564156
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94139538
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94139538
89	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93490270
90	KDM5A_27292631_Chip-Seq_BREAST_Human	0.92589369
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91242481
92	SOX9_26525672_Chip-Seq_HEART_Mouse	0.90194929
93	TBL1_22424771_ChIP-Seq_293T_Human	0.89748070
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.87608189
95	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87440441
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86959759
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.86540462
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.86306053
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.86077944
100	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.85696397

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.41523210
2	MP0002102_abnormal_ear_morphology	3.40559139
3	MP0005423_abnormal_somatic_nervous	2.80774789
4	MP0008995_early_reproductive_senescence	2.63400902
5	MP0006276_abnormal_autonomic_nervous	2.49453025
6	MP0008057_abnormal_DNA_replication	2.42606471
7	MP0003950_abnormal_plasma_membrane	2.27912953
8	MP0008058_abnormal_DNA_repair	2.24516556
9	MP0010094_abnormal_chromosome_stability	2.22228221
10	MP0001529_abnormal_vocalization	2.04410492
11	MP0005551_abnormal_eye_electrophysiolog	2.02722011
12	MP0003890_abnormal_embryonic-extraembry	2.02013820
13	MP0009697_abnormal_copulation	1.81257022
14	MP0003718_maternal_effect	1.78516312
15	MP0009046_muscle_twitch	1.76162644
16	MP0004133_heterotaxia	1.66051079
17	MP0003111_abnormal_nucleus_morphology	1.60851006
18	MP0006035_abnormal_mitochondrial_morpho	1.60486164
19	MP0005410_abnormal_fertilization	1.59900798
20	MP0001986_abnormal_taste_sensitivity	1.56299403
21	MP0004147_increased_porphyrin_level	1.52733397
22	MP0003693_abnormal_embryo_hatching	1.51477403
23	MP0003698_abnormal_male_reproductive	1.49463496
24	MP0001929_abnormal_gametogenesis	1.49435548
25	MP0001486_abnormal_startle_reflex	1.41695192
26	MP0004957_abnormal_blastocyst_morpholog	1.38663326
27	MP0002210_abnormal_sex_determination	1.38111734
28	MP0005253_abnormal_eye_physiology	1.37067761
29	MP0001984_abnormal_olfaction	1.35359178
30	MP0003077_abnormal_cell_cycle	1.27402968
31	MP0005646_abnormal_pituitary_gland	1.26125378
32	MP0003786_premature_aging	1.26109811
33	MP0008877_abnormal_DNA_methylation	1.22190050
34	MP0008932_abnormal_embryonic_tissue	1.21837180
35	MP0000631_abnormal_neuroendocrine_gland	1.20113369
36	MP0002735_abnormal_chemical_nociception	1.19583964
37	MP0003195_calcinosis	1.17944307
38	MP0002938_white_spotting	1.16341070
39	MP0006072_abnormal_retinal_apoptosis	1.15655679
40	MP0004233_abnormal_muscle_weight	1.15557221
41	MP0005499_abnormal_olfactory_system	1.15529915
42	MP0005394_taste/olfaction_phenotype	1.15529915
43	MP0002160_abnormal_reproductive_system	1.15056535
44	MP0003136_yellow_coat_color	1.14403882
45	MP0003221_abnormal_cardiomyocyte_apopto	1.13057787
46	MP0002090_abnormal_vision	1.12986130
47	MP0003937_abnormal_limbs/digits/tail_de	1.12528836
48	MP0008007_abnormal_cellular_replicative	1.11544413
49	MP0000653_abnormal_sex_gland	1.11272014
50	MP0008789_abnormal_olfactory_epithelium	1.11244608
51	MP0001145_abnormal_male_reproductive	1.10226349
52	MP0002234_abnormal_pharynx_morphology	1.09061286
53	MP0002734_abnormal_mechanical_nocicepti	1.08992213
54	MP0002736_abnormal_nociception_after	1.06836347
55	MP0009745_abnormal_behavioral_response	1.06199997
56	MP0006292_abnormal_olfactory_placode	1.05404878
57	MP0001968_abnormal_touch/_nociception	1.04941862
58	MP0001501_abnormal_sleep_pattern	1.04894565
59	MP0000372_irregular_coat_pigmentation	1.01740447
60	MP0003646_muscle_fatigue	1.00825702
61	MP0003385_abnormal_body_wall	1.00604025
62	MP0004084_abnormal_cardiac_muscle	0.97091571
63	MP0002638_abnormal_pupillary_reflex	0.94778668
64	MP0000647_abnormal_sebaceous_gland	0.94745026
65	MP0004859_abnormal_synaptic_plasticity	0.94536708
66	MP0005187_abnormal_penis_morphology	0.93791163
67	MP0003635_abnormal_synaptic_transmissio	0.93590631
68	MP0003121_genomic_imprinting	0.93114374
69	MP0002184_abnormal_innervation	0.92787367
70	MP0002752_abnormal_somatic_nervous	0.92010769
71	MP0004085_abnormal_heartbeat	0.91557375
72	MP0008775_abnormal_heart_ventricle	0.91306075
73	MP0005645_abnormal_hypothalamus_physiol	0.91081978
74	MP0004924_abnormal_behavior	0.90577054
75	MP0005386_behavior/neurological_phenoty	0.90577054
76	MP0005266_abnormal_metabolism	0.90078768
77	MP0002272_abnormal_nervous_system	0.90011509
78	MP0008872_abnormal_physiological_respon	0.88963138
79	MP0004142_abnormal_muscle_tone	0.86768333
80	MP0002161_abnormal_fertility/fecundity	0.86766389
81	MP0003119_abnormal_digestive_system	0.85960962
82	MP0000358_abnormal_cell_content/	0.84094585
83	MP0000569_abnormal_digit_pigmentation	0.83560537
84	MP0002751_abnormal_autonomic_nervous	0.83030400
85	MP0002557_abnormal_social/conspecific_i	0.82898598
86	MP0000778_abnormal_nervous_system	0.81973395
87	MP0002876_abnormal_thyroid_physiology	0.81661353
88	MP0001293_anophthalmia	0.81319230
89	MP0002572_abnormal_emotion/affect_behav	0.80838477
90	MP0000955_abnormal_spinal_cord	0.80356298
91	MP0005647_abnormal_sex_gland	0.79314789
92	MP0002067_abnormal_sensory_capabilities	0.78402962
93	MP0002233_abnormal_nose_morphology	0.78385618
94	MP0002882_abnormal_neuron_morphology	0.78295914
95	MP0003699_abnormal_female_reproductive	0.75924254
96	MP0000427_abnormal_hair_cycle	0.75817359
97	MP0002928_abnormal_bile_duct	0.74112498
98	MP0008770_decreased_survivor_rate	0.73539749
99	MP0003861_abnormal_nervous_system	0.73396907
100	MP0005248_abnormal_Harderian_gland	0.72807535

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.37655120
2	Pancreatic fibrosis (HP:0100732)	3.31805709
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.22223032
4	Small hand (HP:0200055)	3.22076757
5	Chromsome breakage (HP:0040012)	3.15386412
6	True hermaphroditism (HP:0010459)	3.05810512
7	Birth length less than 3rd percentile (HP:0003561)	2.91708419
8	Hip dysplasia (HP:0001385)	2.82207992
9	Abnormality of midbrain morphology (HP:0002418)	2.81495932
10	Molar tooth sign on MRI (HP:0002419)	2.81495932
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.79581336
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.79116348
13	Progressive inability to walk (HP:0002505)	2.74056255
14	Chronic hepatic failure (HP:0100626)	2.69464580
15	Cortical dysplasia (HP:0002539)	2.68788771
16	Carpal bone hypoplasia (HP:0001498)	2.66397253
17	Abnormality of the labia minora (HP:0012880)	2.55931499
18	Type II lissencephaly (HP:0007260)	2.55448357
19	Hand muscle atrophy (HP:0009130)	2.52141735
20	Lissencephaly (HP:0001339)	2.47907199
21	Abnormality of chromosome stability (HP:0003220)	2.45837023
22	Cerebellar dysplasia (HP:0007033)	2.42435963
23	Meckel diverticulum (HP:0002245)	2.39023916
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.38540313
25	Abnormality of the ileum (HP:0001549)	2.37752025
26	Abnormal gallbladder physiology (HP:0012438)	2.35852988
27	Cholecystitis (HP:0001082)	2.35852988
28	Tubulointerstitial nephritis (HP:0001970)	2.34785097
29	Renal cortical cysts (HP:0000803)	2.32692943
30	Ependymoma (HP:0002888)	2.31657181
31	Gaze-evoked nystagmus (HP:0000640)	2.31627324
32	Urinary urgency (HP:0000012)	2.30535020
33	Thyroid-stimulating hormone excess (HP:0002925)	2.30247337
34	Nephronophthisis (HP:0000090)	2.27774756
35	Anencephaly (HP:0002323)	2.27284243
36	Sloping forehead (HP:0000340)	2.26745546
37	Abnormality of alanine metabolism (HP:0010916)	2.26191331
38	Hyperalaninemia (HP:0003348)	2.26191331
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26191331
40	Retinal dysplasia (HP:0007973)	2.26140179
41	Broad-based gait (HP:0002136)	2.26042937
42	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.25680970
43	Short tibia (HP:0005736)	2.25406708
44	Abnormality of the preputium (HP:0100587)	2.22428354
45	Inability to walk (HP:0002540)	2.18764518
46	Supernumerary spleens (HP:0009799)	2.18153158
47	Cystic liver disease (HP:0006706)	2.18027465
48	Fetal akinesia sequence (HP:0001989)	2.17226790
49	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.16648417
50	Protruding tongue (HP:0010808)	2.10022651
51	Abnormality of the renal medulla (HP:0100957)	2.08040415
52	Abnormal lung lobation (HP:0002101)	2.04263352
53	Preaxial hand polydactyly (HP:0001177)	2.03996151
54	Duplicated collecting system (HP:0000081)	1.99154854
55	Diaphragmatic weakness (HP:0009113)	1.99001548
56	Postaxial foot polydactyly (HP:0001830)	1.98764912
57	Hypobetalipoproteinemia (HP:0003563)	1.98077384
58	Abnormality of the renal cortex (HP:0011035)	1.97363401
59	Astrocytoma (HP:0009592)	1.95113172
60	Abnormality of the astrocytes (HP:0100707)	1.95113172
61	Astigmatism (HP:0000483)	1.93278146
62	Sclerocornea (HP:0000647)	1.91859956
63	Aplasia of the musculature (HP:0100854)	1.91423730
64	Abnormal biliary tract physiology (HP:0012439)	1.90746412
65	Bile duct proliferation (HP:0001408)	1.90746412
66	Abnormality of the renal collecting system (HP:0004742)	1.90062140
67	Acanthocytosis (HP:0001927)	1.89819571
68	Attenuation of retinal blood vessels (HP:0007843)	1.89282434
69	Abnormality of the pons (HP:0007361)	1.85092712
70	Hypoplasia of the pons (HP:0012110)	1.84655427
71	Volvulus (HP:0002580)	1.83349135
72	Hypothermia (HP:0002045)	1.82895486
73	Medial flaring of the eyebrow (HP:0010747)	1.82742765
74	Gait imbalance (HP:0002141)	1.82269406
75	Abnormality of DNA repair (HP:0003254)	1.82236526
76	Ileus (HP:0002595)	1.80574247
77	Spinal muscular atrophy (HP:0007269)	1.80200381
78	Glioma (HP:0009733)	1.79548724
79	Male pseudohermaphroditism (HP:0000037)	1.79303994
80	Congenital primary aphakia (HP:0007707)	1.78266519
81	Methylmalonic acidemia (HP:0002912)	1.78016335
82	Nephrogenic diabetes insipidus (HP:0009806)	1.77084847
83	Proximal tubulopathy (HP:0000114)	1.74935934
84	Abnormality of the carotid arteries (HP:0005344)	1.73418358
85	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.72149984
86	Dandy-Walker malformation (HP:0001305)	1.71831709
87	Concave nail (HP:0001598)	1.70816292
88	High anterior hairline (HP:0009890)	1.70651811
89	Duodenal stenosis (HP:0100867)	1.70033774
90	Small intestinal stenosis (HP:0012848)	1.70033774
91	Intestinal atresia (HP:0011100)	1.69538961
92	Prominent nasal bridge (HP:0000426)	1.69379445
93	Genital tract atresia (HP:0001827)	1.68751457
94	Absent speech (HP:0001344)	1.68049572
95	Enlarged kidneys (HP:0000105)	1.67968081
96	Upper limb muscle weakness (HP:0003484)	1.67548378
97	Oligohydramnios (HP:0001562)	1.66308257
98	Poor coordination (HP:0002370)	1.65638094
99	Heterotopia (HP:0002282)	1.65032951
100	Midline defect of the nose (HP:0004122)	1.64763389

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.07989648
2	MAP3K4	2.95691145
3	MARK1	2.54849128
4	ZAK	2.43659652
5	TRIM28	2.34914576
6	NTRK3	2.31925694
7	TAOK3	2.29132770
8	SRPK1	2.28747951
9	EIF2AK1	2.12785190
10	MAP4K2	2.09564590
11	WNK3	2.08905790
12	PINK1	2.02346685
13	ADRBK2	1.96424415
14	CDC7	1.96331942
15	MAPK13	1.92510168
16	CASK	1.92371260
17	BCR	1.92173752
18	PDK2	1.91771268
19	TTK	1.88646838
20	MAP2K7	1.83374441
21	EIF2AK3	1.82459029
22	CLK1	1.82382002
23	PLK4	1.81113804
24	TSSK6	1.81066438
25	NEK2	1.74178967
26	ERBB4	1.52660527
27	NEK1	1.50204293
28	PBK	1.49183407
29	CCNB1	1.48993682
30	BRSK2	1.43573287
31	AKT3	1.40001632
32	TLK1	1.35242495
33	BRD4	1.28255194
34	BMPR1B	1.24626281
35	KSR1	1.23312274
36	WNK4	1.20365243
37	CHEK2	1.18488592
38	ATR	1.10925026
39	WEE1	1.10241624
40	GRK1	1.08313702
41	INSRR	1.02538942
42	RPS6KA4	1.01029875
43	STK3	1.00741691
44	ERBB3	1.00449594
45	PAK6	0.98516817
46	ATM	0.94062842
47	PLK1	0.92590977
48	BUB1	0.91121241
49	NUAK1	0.89130684
50	MKNK2	0.88753456
51	LATS1	0.87431536
52	NME1	0.84095391
53	OXSR1	0.82225002
54	PRKAA1	0.81062845
55	PKN1	0.79925805
56	KSR2	0.76849522
57	RAF1	0.75870923
58	EPHA4	0.74041822
59	DYRK2	0.70883558
60	MAP3K7	0.70430127
61	PAK3	0.70337698
62	RPS6KA5	0.69757512
63	CDK1	0.67016941
64	TNIK	0.66486509
65	CSNK1E	0.65107872
66	PLK3	0.64963713
67	STK39	0.64413918
68	DYRK3	0.63642677
69	ACVR1B	0.63473725
70	SIK2	0.61391048
71	PIM2	0.61343468
72	MKNK1	0.61327369
73	AURKB	0.60711408
74	PRKCE	0.59953053
75	CSNK1G1	0.58724737
76	CSNK1A1L	0.58074946
77	CDK2	0.51968944
78	STK38L	0.50683094
79	BMPR2	0.49831640
80	VRK1	0.49575735
81	PRKCG	0.48882753
82	CHEK1	0.47282449
83	BRSK1	0.46533683
84	MARK3	0.46168604
85	GSK3B	0.43880739
86	PLK2	0.43876425
87	PRKACB	0.43458286
88	CDK3	0.42606221
89	FLT3	0.40927362
90	MINK1	0.40868905
91	STK4	0.39451363
92	TNK2	0.37392716
93	CSNK1G3	0.37153120
94	PRKAA2	0.36876931
95	CSNK1A1	0.35891047
96	MAP2K1	0.35656827
97	PIK3CG	0.35187776
98	MAPK14	0.35133484
99	ADRBK1	0.34837582
100	CSNK2A2	0.34192867

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.77993342
2	Butanoate metabolism_Homo sapiens_hsa00650	2.68656229
3	Homologous recombination_Homo sapiens_hsa03440	2.51909758
4	Nicotine addiction_Homo sapiens_hsa05033	2.36772057
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.30363411
6	Basal transcription factors_Homo sapiens_hsa03022	2.30124437
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23776756
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.19845914
9	Olfactory transduction_Homo sapiens_hsa04740	2.12406926
10	One carbon pool by folate_Homo sapiens_hsa00670	2.08863577
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.07290240
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.97940555
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81763618
14	Propanoate metabolism_Homo sapiens_hsa00640	1.81239932
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80009421
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.79239940
17	RNA transport_Homo sapiens_hsa03013	1.75033777
18	Taste transduction_Homo sapiens_hsa04742	1.65977512
19	Mismatch repair_Homo sapiens_hsa03430	1.64302571
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.62547891
21	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.53247128
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.48713743
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.46190350
24	DNA replication_Homo sapiens_hsa03030	1.45780182
25	Phototransduction_Homo sapiens_hsa04744	1.41884876
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39288557
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.35420317
28	RNA degradation_Homo sapiens_hsa03018	1.33047990
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28212293
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.28183073
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24615906
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22095446
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.20945934
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20935504
35	Base excision repair_Homo sapiens_hsa03410	1.17314448
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.15359266
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12592857
38	Retinol metabolism_Homo sapiens_hsa00830	1.05938763
39	RNA polymerase_Homo sapiens_hsa03020	1.05885716
40	Cell cycle_Homo sapiens_hsa04110	1.05667974
41	Spliceosome_Homo sapiens_hsa03040	1.02794083
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02760555
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.01631591
44	mRNA surveillance pathway_Homo sapiens_hsa03015	1.01551317
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99770909
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98911795
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.97889524
48	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96759549
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.95435194
50	GABAergic synapse_Homo sapiens_hsa04727	0.95079704
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.91434049
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91022544
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.89376797
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.88534782
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.88214101
56	Alcoholism_Homo sapiens_hsa05034	0.88109815
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86530593
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84710798
59	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.82634629
60	Regulation of autophagy_Homo sapiens_hsa04140	0.82261359
61	Caffeine metabolism_Homo sapiens_hsa00232	0.82110041
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.80824141
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.80775537
64	Purine metabolism_Homo sapiens_hsa00230	0.80607919
65	ABC transporters_Homo sapiens_hsa02010	0.80145316
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79324884
67	Circadian rhythm_Homo sapiens_hsa04710	0.76607785
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.76163469
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74729000
70	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.74648015
71	Arginine biosynthesis_Homo sapiens_hsa00220	0.74447834
72	Glutathione metabolism_Homo sapiens_hsa00480	0.74207395
73	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.73617910
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73499528
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.72706229
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71698278
77	Lysine degradation_Homo sapiens_hsa00310	0.69998650
78	Metabolic pathways_Homo sapiens_hsa01100	0.68271557
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66188923
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65855002
81	Oocyte meiosis_Homo sapiens_hsa04114	0.65782543
82	Carbon metabolism_Homo sapiens_hsa01200	0.61704674
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.61109930
84	Morphine addiction_Homo sapiens_hsa05032	0.57689399
85	Protein export_Homo sapiens_hsa03060	0.56933426
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56831652
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54414557
88	Peroxisome_Homo sapiens_hsa04146	0.54022493
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53265141
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.50202167
91	Fatty acid degradation_Homo sapiens_hsa00071	0.49973242
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49719456
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49043689
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47609418
95	Huntingtons disease_Homo sapiens_hsa05016	0.46231130
96	p53 signaling pathway_Homo sapiens_hsa04115	0.42897250
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39559771
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39305883
99	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.37996321
100	Proteasome_Homo sapiens_hsa03050	0.37100890

CCDC144NL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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