CCDC151

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing coiled-coil domains. The encoded protein functions in outer dynein arm assembly and is required for motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.17326979
2sperm motility (GO:0030317)8.04691983
3regulation of cilium movement (GO:0003352)8.00827594
4ventricular system development (GO:0021591)7.51813046
5axoneme assembly (GO:0035082)7.39156991
6protein localization to cilium (GO:0061512)6.77483741
7fusion of sperm to egg plasma membrane (GO:0007342)6.76257748
8intraciliary transport (GO:0042073)6.68057298
9acrosome reaction (GO:0007340)6.38929191
10acrosome assembly (GO:0001675)6.25417157
11sperm-egg recognition (GO:0035036)6.24556203
12binding of sperm to zona pellucida (GO:0007339)5.88577111
13microtubule severing (GO:0051013)5.86321940
14spermatid development (GO:0007286)5.81866647
15primary alcohol catabolic process (GO:0034310)5.64904163
16vitamin transmembrane transport (GO:0035461)5.61124542
17multicellular organism reproduction (GO:0032504)5.60697149
18cell-cell recognition (GO:0009988)5.54994595
19piRNA metabolic process (GO:0034587)5.49108257
20cell wall macromolecule metabolic process (GO:0044036)5.47210751
21cell wall macromolecule catabolic process (GO:0016998)5.47210751
22GTP biosynthetic process (GO:0006183)5.39327779
23microtubule bundle formation (GO:0001578)5.24747101
24nucleoside diphosphate phosphorylation (GO:0006165)5.21912485
25left/right axis specification (GO:0070986)5.21753040
26male meiosis (GO:0007140)5.14156515
27plasma membrane fusion (GO:0045026)5.13175927
28cilium morphogenesis (GO:0060271)5.11248015
29diterpenoid biosynthetic process (GO:0016102)5.07965044
30regulation of microtubule-based movement (GO:0060632)5.07001999
31cilium organization (GO:0044782)4.96184028
32cilium assembly (GO:0042384)4.79964681
33UTP biosynthetic process (GO:0006228)4.79187114
34synaptonemal complex organization (GO:0070193)4.72189025
35reproduction (GO:0000003)4.67140778
36C21-steroid hormone biosynthetic process (GO:0006700)4.64484847
37ethanol metabolic process (GO:0006067)4.60718304
38single fertilization (GO:0007338)4.59395182
39microtubule depolymerization (GO:0007019)4.57400919
40UTP metabolic process (GO:0046051)4.56871205
41response to xenobiotic stimulus (GO:0009410)4.55854083
42establishment of apical/basal cell polarity (GO:0035089)4.54696306
43protein polyglutamylation (GO:0018095)4.42496523
44negative regulation of T cell differentiation in thymus (GO:0033085)4.38678703
45establishment of monopolar cell polarity (GO:0061162)4.37054124
46establishment or maintenance of monopolar cell polarity (GO:0061339)4.37054124
47microtubule-based movement (GO:0007018)4.34787001
48microtubule polymerization or depolymerization (GO:0031109)4.30500025
49synaptonemal complex assembly (GO:0007130)4.27337242
50negative regulation of inclusion body assembly (GO:0090084)4.23746383
51one-carbon compound transport (GO:0019755)4.20192896
52fertilization (GO:0009566)4.15680930
53pyrimidine-containing compound transmembrane transport (GO:0072531)4.06240633
54detection of calcium ion (GO:0005513)4.04645785
55cellular component assembly involved in morphogenesis (GO:0010927)4.01843896
56progesterone metabolic process (GO:0042448)3.99547767
57spermatogenesis (GO:0007283)3.97374515
58male gamete generation (GO:0048232)3.95354121
59glomerular epithelial cell development (GO:0072310)3.94849232
60sperm capacitation (GO:0048240)3.90103725
61phosphorelay signal transduction system (GO:0000160)3.85647409
62guanosine-containing compound biosynthetic process (GO:1901070)3.82668868
63terpenoid biosynthetic process (GO:0016114)3.82153289
64sensory perception of smell (GO:0007608)3.76515723
65left/right pattern formation (GO:0060972)3.72053661
66retinoic acid metabolic process (GO:0042573)3.69532049
67regulation of interleukin-5 production (GO:0032674)3.68396420
68tolerance induction (GO:0002507)3.63650738
69gamete generation (GO:0007276)3.62516722
70male meiosis I (GO:0007141)3.58129761
71centriole assembly (GO:0098534)3.55587910
72negative regulation of immunoglobulin mediated immune response (GO:0002890)3.54756887
73negative regulation of B cell mediated immunity (GO:0002713)3.54756887
74organic cation transport (GO:0015695)3.54043421
75nonmotile primary cilium assembly (GO:0035058)3.52330136
76regulation of inclusion body assembly (GO:0090083)3.51538576
77calcium ion-dependent exocytosis (GO:0017156)3.45153159
78ADP metabolic process (GO:0046031)3.44235778
79CTP metabolic process (GO:0046036)3.42010235
80CTP biosynthetic process (GO:0006241)3.42010235
81cytoplasmic microtubule organization (GO:0031122)3.35677723
82ethanol oxidation (GO:0006069)3.27208327
83germ cell development (GO:0007281)3.25128954
84lateral ventricle development (GO:0021670)3.24515770
85regulation of interleukin-13 production (GO:0032656)3.21638914
86establishment of tissue polarity (GO:0007164)3.20642100
87establishment of planar polarity (GO:0001736)3.20642100
88DNA methylation involved in gamete generation (GO:0043046)3.17271877
89peptidyl-glutamic acid modification (GO:0018200)3.11657764
90pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.11061584
91cellular process involved in reproduction in multicellular organism (GO:0022412)3.07092509
92pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.04832497
93cell projection assembly (GO:0030031)3.04690357
94protein insertion into membrane (GO:0051205)3.04359586
95cell recognition (GO:0008037)3.03126350
96retinal rod cell development (GO:0046548)3.02761636
97negative regulation of humoral immune response (GO:0002921)2.97077447
98regulation of germinal center formation (GO:0002634)2.95604006
99base-excision repair, AP site formation (GO:0006285)2.95447722
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94593627
101regulation of collateral sprouting (GO:0048670)2.93641192
102regulation of protein polyubiquitination (GO:1902914)2.92835502
103meiosis I (GO:0007127)2.92347938
104photoreceptor cell maintenance (GO:0045494)2.91188884
105determination of bilateral symmetry (GO:0009855)2.91109574
106positive regulation of tolerance induction (GO:0002645)2.90624825
107exogenous drug catabolic process (GO:0042738)2.89658807
108retinol metabolic process (GO:0042572)2.89269123
109nucleoside diphosphate metabolic process (GO:0009132)2.89228874
110C21-steroid hormone metabolic process (GO:0008207)2.86545452
111multicellular organismal reproductive process (GO:0048609)2.84961340
112specification of symmetry (GO:0009799)2.83028885
113nucleotide phosphorylation (GO:0046939)2.82568881
114centriole replication (GO:0007099)2.79967089
115smoothened signaling pathway (GO:0007224)2.77362570
116positive regulation of smoothened signaling pathway (GO:0045880)2.72481631
117organelle assembly (GO:0070925)2.70413193
118negative regulation of organelle assembly (GO:1902116)2.69714986
119meiotic nuclear division (GO:0007126)2.67791206
120primary alcohol metabolic process (GO:0034308)2.66717894
121aldehyde catabolic process (GO:0046185)2.64972130
122synapsis (GO:0007129)2.64266936
123embryonic camera-type eye development (GO:0031076)2.63988171
124carnitine metabolic process (GO:0009437)2.62050894
125chromosome organization involved in meiosis (GO:0070192)2.61212018
126pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.61179983
127embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60220998
128meiotic cell cycle (GO:0051321)2.59156745
129embryonic body morphogenesis (GO:0010172)2.58693044
130lateral sprouting from an epithelium (GO:0060601)2.57647439
131sensory perception of chemical stimulus (GO:0007606)2.55786460
132spinal cord motor neuron differentiation (GO:0021522)2.55749174
133glutathione derivative metabolic process (GO:1901685)2.55448589
134glutathione derivative biosynthetic process (GO:1901687)2.55448589
135regulation of microtubule depolymerization (GO:0031114)2.53452732
136nonribosomal peptide biosynthetic process (GO:0019184)2.52502073
137regulation of autophagic vacuole assembly (GO:2000785)2.52260893
138lung epithelium development (GO:0060428)2.50564260
139microtubule-based process (GO:0007017)2.50157649
140phosphatidylethanolamine biosynthetic process (GO:0006646)2.49624859
141pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47971931
142lactate metabolic process (GO:0006089)2.47364549
143alditol metabolic process (GO:0019400)2.45097698
144spermatid nucleus differentiation (GO:0007289)2.43336267
145nerve growth factor signaling pathway (GO:0038180)2.42254637
146establishment of nucleus localization (GO:0040023)2.39067658
147determination of left/right symmetry (GO:0007368)2.38734423
148pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.35501075
149adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.34643289
150modulation by virus of host process (GO:0019054)2.34177373
151axonemal dynein complex assembly (GO:0070286)14.1568799
152cilium or flagellum-dependent cell motility (GO:0001539)13.5372939
153cilium movement (GO:0003341)12.1097267
154epithelial cilium movement (GO:0003351)10.2352080
155motile cilium assembly (GO:0044458)10.1441935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.06720333
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.43094555
3EZH2_22144423_ChIP-Seq_EOC_Human5.28354639
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42291941
5VDR_22108803_ChIP-Seq_LS180_Human2.77116683
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60436730
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.59695535
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.26441721
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.04058977
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96108474
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80486948
12REST_21632747_ChIP-Seq_MESCs_Mouse1.80045492
13TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74453049
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72318622
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69168881
16ZNF274_21170338_ChIP-Seq_K562_Hela1.68487267
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66295057
18DROSHA_22980978_ChIP-Seq_HELA_Human1.65742478
19SMC4_20622854_ChIP-Seq_HELA_Human1.64763986
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.60149987
21SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.56456047
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54247645
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53994216
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.52333277
25ETV1_20927104_ChIP-Seq_GIST48_Human1.50858236
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50685868
27STAT1_20625510_ChIP-Seq_HELA_Human1.48222360
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.47120570
29* ELF1_20517297_ChIP-Seq_JURKAT_Human1.45967536
30IGF1R_20145208_ChIP-Seq_DFB_Human1.44828923
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44017412
32PHF8_20622853_ChIP-Seq_HELA_Human1.43658329
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39921626
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39752269
35CTCF_27219007_Chip-Seq_Bcells_Human1.39538849
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38651680
37MYC_19829295_ChIP-Seq_ESCs_Human1.37733336
38CTCF_20526341_ChIP-Seq_ESCs_Human1.37128603
39BCAT_22108803_ChIP-Seq_LS180_Human1.36302573
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36063913
41PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35833137
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.33688620
43ERA_21632823_ChIP-Seq_H3396_Human1.32653223
44P68_20966046_ChIP-Seq_HELA_Human1.30215536
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30157258
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30157258
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29539069
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.28961298
49RBPJ_21746931_ChIP-Seq_IB4_Human1.28733765
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.28329524
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27989792
52PHF8_20622854_ChIP-Seq_HELA_Human1.26083529
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25852380
54ER_23166858_ChIP-Seq_MCF-7_Human1.25714998
55GBX2_23144817_ChIP-Seq_PC3_Human1.25593810
56CBX2_22325352_ChIP-Seq_293T-Rex_Human1.24520307
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24362730
58AHR_22903824_ChIP-Seq_MCF-7_Human1.23555144
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23057508
60CBP_20019798_ChIP-Seq_JUKART_Human1.23057508
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22881845
62TP63_22573176_ChIP-Seq_HFKS_Human1.21487267
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.21446856
64RNF2_27304074_Chip-Seq_NSC_Mouse1.21229612
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.21223273
66OCT4_20526341_ChIP-Seq_ESCs_Human1.21135766
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.20522653
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18982585
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18896434
70SOX2_21211035_ChIP-Seq_LN229_Human1.18661178
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.18310789
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17784142
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17171111
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17019090
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.16678043
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16149821
77NFYA_21822215_ChIP-Seq_K562_Human1.16092035
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.15678271
79NFYB_21822215_ChIP-Seq_K562_Human1.14484000
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14316918
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14205057
82SMAD4_21799915_ChIP-Seq_A2780_Human1.14048084
83AR_21572438_ChIP-Seq_LNCaP_Human1.13841355
84TBL1_22424771_ChIP-Seq_293T_Human1.13826832
85E2F1_20622854_ChIP-Seq_HELA_Human1.13393428
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.13050111
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13050111
88P53_21459846_ChIP-Seq_SAOS-2_Human1.12524499
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12430558
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12344070
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11684528
92TP63_23658742_ChIP-Seq_EP156T_Human1.11384971
93KLF5_25053715_ChIP-Seq_YYC3_Human1.11208467
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10453857
95KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10287844
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.09090204
97* NCOR_22424771_ChIP-Seq_293T_Human1.08830379
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08408907
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.07853154
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07851640
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07716756
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05810810
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05496478
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04301171
105P300_27268052_Chip-Seq_Bcells_Human1.03079977
106* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02854709
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01641404
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01396988
109LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01339455
110* SMRT_27268052_Chip-Seq_Bcells_Human1.01222843
111RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00760059
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00692355
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.00681549
114TAF2_19829295_ChIP-Seq_ESCs_Human1.00452134
115RUNX2_22187159_ChIP-Seq_PCA_Human1.00334410
116GF1_26923725_Chip-Seq_HPCs_Mouse0.99867232
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99790974
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.99323213
119FUS_26573619_Chip-Seq_HEK293_Human0.99256787
120NANOG_20526341_ChIP-Seq_ESCs_Human0.98576670
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98273803
122TCF4_22108803_ChIP-Seq_LS180_Human0.97965636
123LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.97956599
124GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.97709521
125AR_20517297_ChIP-Seq_VCAP_Human0.97701720
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97357620
127STAT3_23295773_ChIP-Seq_U87_Human0.96928643
128TAF15_26573619_Chip-Seq_HEK293_Human0.96761058
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.96638220
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95754321
131JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95455233
132ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95446221
133CEBPB_22108803_ChIP-Seq_LS180_Human0.94941590
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94741181
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94396566
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94100380
137GATA3_21867929_ChIP-Seq_CD8_Mouse0.94017420
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.93705664
139NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93620132
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93352256
141ERG_20517297_ChIP-Seq_VCAP_Human0.92969334
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91636144
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91289268
144STAT1_17558387_ChIP-Seq_HELA_Human0.91275985
145RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91092560
146KDM2B_26808549_Chip-Seq_REH_Human0.90976563
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89756563
148KLF4_19829295_ChIP-Seq_ESCs_Human0.89640681
149SPI1_26923725_Chip-Seq_HPCs_Mouse0.88855792
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.88398605
151FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87847671
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.87433084
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87101349
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86415746
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86328211
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.85753779
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85060155
158MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83792870
159SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82645067
160RARB_27405468_Chip-Seq_BRAIN_Mouse0.82054750
161SOX9_26525672_Chip-Seq_HEART_Mouse0.81864696
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81745248
163RNF2_27304074_Chip-Seq_ESCs_Mouse0.81395957
164TCF4_23295773_ChIP-Seq_U87_Human0.81199994
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.80579693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.76803034
2MP0001984_abnormal_olfaction4.76142783
3MP0002653_abnormal_ependyma_morphology4.32458145
4MP0003698_abnormal_male_reproductive3.86434468
5MP0002132_abnormal_respiratory_system3.58100364
6MP0001929_abnormal_gametogenesis3.22019516
7MP0002277_abnormal_respiratory_mucosa3.15602646
8MP0002160_abnormal_reproductive_system3.14748478
9MP0002139_abnormal_hepatobiliary_system3.14095552
10MP0004043_abnormal_pH_regulation2.97803923
11MP0008004_abnormal_stomach_pH2.90397608
12MP0005623_abnormal_meninges_morphology2.68707708
13MP0002928_abnormal_bile_duct2.51562566
14MP0009379_abnormal_foot_pigmentation2.49130745
15MP0004133_heterotaxia2.47161470
16MP0000383_abnormal_hair_follicle2.35029800
17MP0005647_abnormal_sex_gland2.33508430
18MP0002210_abnormal_sex_determination2.25046285
19MP0002161_abnormal_fertility/fecundity2.22062213
20MP0005360_urolithiasis2.14748766
21MP0005085_abnormal_gallbladder_physiolo2.13008296
22MP0003136_yellow_coat_color2.10859484
23MP0005365_abnormal_bile_salt2.09678358
24MP0008877_abnormal_DNA_methylation2.06700811
25MP0004859_abnormal_synaptic_plasticity2.00527416
26MP0010678_abnormal_skin_adnexa1.93230612
27MP0005670_abnormal_white_adipose1.86083884
28MP0001145_abnormal_male_reproductive1.84410199
29MP0003878_abnormal_ear_physiology1.84205097
30MP0005377_hearing/vestibular/ear_phenot1.84205097
31MP0002638_abnormal_pupillary_reflex1.74948257
32MP0000678_abnormal_parathyroid_gland1.74554040
33MP0008875_abnormal_xenobiotic_pharmacok1.73132166
34MP0000653_abnormal_sex_gland1.68480067
35MP0003806_abnormal_nucleotide_metabolis1.64983273
36MP0000566_synostosis1.60676425
37MP0003252_abnormal_bile_duct1.59291945
38MP0004270_analgesia1.58769266
39MP0009046_muscle_twitch1.54586252
40MP0005389_reproductive_system_phenotype1.48297403
41MP0002735_abnormal_chemical_nociception1.42989336
42MP0005646_abnormal_pituitary_gland1.42114181
43MP0003635_abnormal_synaptic_transmissio1.41417188
44MP0004858_abnormal_nervous_system1.39806220
45MP0002282_abnormal_trachea_morphology1.35119749
46MP0002876_abnormal_thyroid_physiology1.31471668
47MP0002168_other_aberrant_phenotype1.29447375
48MP0001188_hyperpigmentation1.26177655
49MP0000778_abnormal_nervous_system1.25557942
50MP0005253_abnormal_eye_physiology1.21337130
51MP0002063_abnormal_learning/memory/cond1.11513323
52MP0003880_abnormal_central_pattern1.08920603
53MP0002572_abnormal_emotion/affect_behav1.07543452
54MP0010329_abnormal_lipoprotein_level1.06275622
55MP0002249_abnormal_larynx_morphology1.05883353
56MP0003890_abnormal_embryonic-extraembry1.05012849
57MP0005551_abnormal_eye_electrophysiolog1.04182368
58MP0005395_other_phenotype1.03972303
59MP0001486_abnormal_startle_reflex1.03649325
60MP0001485_abnormal_pinna_reflex1.01347469
61MP0009745_abnormal_behavioral_response0.99835738
62MP0002272_abnormal_nervous_system0.99211755
63MP0001970_abnormal_pain_threshold0.99128061
64MP0009780_abnormal_chondrocyte_physiolo0.98859462
65MP0002557_abnormal_social/conspecific_i0.97745953
66MP0002102_abnormal_ear_morphology0.95955992
67MP0003283_abnormal_digestive_organ0.94937999
68MP0002064_seizures0.93480370
69MP0004811_abnormal_neuron_physiology0.92704504
70MP0001765_abnormal_ion_homeostasis0.92602241
71MP0002152_abnormal_brain_morphology0.92439562
72MP0006072_abnormal_retinal_apoptosis0.92110419
73MP0008995_early_reproductive_senescence0.91788132
74MP0003942_abnormal_urinary_system0.91212833
75MP0002234_abnormal_pharynx_morphology0.89289244
76MP0002734_abnormal_mechanical_nocicepti0.87814888
77MP0004742_abnormal_vestibular_system0.87137631
78MP0000631_abnormal_neuroendocrine_gland0.86417614
79MP0001346_abnormal_lacrimal_gland0.85275876
80MP0008058_abnormal_DNA_repair0.83736441
81MP0002184_abnormal_innervation0.83116269
82MP0002882_abnormal_neuron_morphology0.81955662
83MP0001324_abnormal_eye_pigmentation0.81184149
84MP0001963_abnormal_hearing_physiology0.80479724
85MP0001293_anophthalmia0.79509999
86MP0002909_abnormal_adrenal_gland0.77698419
87MP0002233_abnormal_nose_morphology0.77083106
88MP0003937_abnormal_limbs/digits/tail_de0.75610846
89MP0003938_abnormal_ear_development0.74001048
90MP0004233_abnormal_muscle_weight0.73788483
91MP0001502_abnormal_circadian_rhythm0.73335356
92MP0001968_abnormal_touch/_nociception0.72733067
93MP0005220_abnormal_exocrine_pancreas0.72237584
94MP0002752_abnormal_somatic_nervous0.72233549
95MP0004019_abnormal_vitamin_homeostasis0.72067556
96MP0005645_abnormal_hypothalamus_physiol0.71985494
97MP0003633_abnormal_nervous_system0.71909571
98MP0005310_abnormal_salivary_gland0.71860464
99MP0003634_abnormal_glial_cell0.71637211
100MP0003718_maternal_effect0.71362710
101MP0005195_abnormal_posterior_eye0.71305914
102MP0000427_abnormal_hair_cycle0.71225465
103MP0003861_abnormal_nervous_system0.70525905
104MP0005332_abnormal_amino_acid0.70299326
105MP0002229_neurodegeneration0.70185306
106MP0005394_taste/olfaction_phenotype0.70003997
107MP0005499_abnormal_olfactory_system0.70003997
108MP0008872_abnormal_physiological_respon0.69695011
109MP0003631_nervous_system_phenotype0.67768015
110MP0000955_abnormal_spinal_cord0.66357744
111MP0010386_abnormal_urinary_bladder0.66273492
112MP0001944_abnormal_pancreas_morphology0.65685409
113MP0005391_vision/eye_phenotype0.65468097
114MP0003329_amyloid_beta_deposits0.65278038
115MP0008789_abnormal_olfactory_epithelium0.65220861
116MP0001177_atelectasis0.65094573
117MP0003011_delayed_dark_adaptation0.64813457
118MP0004142_abnormal_muscle_tone0.64607179
119MP0002118_abnormal_lipid_homeostasis0.64321755
120MP0005248_abnormal_Harderian_gland0.64056946
121MP0002127_abnormal_cardiovascular_syste0.63817976
122MP0005409_darkened_coat_color0.63338500
123MP0005636_abnormal_mineral_homeostasis0.62804627
124MP0002733_abnormal_thermal_nociception0.62282108
125MP0002295_abnormal_pulmonary_circulatio0.60931522
126MP0004381_abnormal_hair_follicle0.60838776
127MP0001905_abnormal_dopamine_level0.60829186
128MP0002736_abnormal_nociception_after0.60558640
129MP0003195_calcinosis0.60460589
130MP0005083_abnormal_biliary_tract0.58293424
131MP0005187_abnormal_penis_morphology0.57928289
132MP0004885_abnormal_endolymph0.57563794
133MP0002822_catalepsy0.57266397
134MP0003879_abnormal_hair_cell0.56814317
135MP0005423_abnormal_somatic_nervous0.56294680
136MP0003953_abnormal_hormone_level0.56033628
137MP0000026_abnormal_inner_ear0.55789227
138MP0002067_abnormal_sensory_capabilities0.54480940
139MP0001440_abnormal_grooming_behavior0.54321921
140MP0003943_abnormal_hepatobiliary_system0.53596493
141MP0002066_abnormal_motor_capabilities/c0.53519104
142MP0000613_abnormal_salivary_gland0.52911828
143MP0005319_abnormal_enzyme/_coenzyme0.51826275
144MP0010368_abnormal_lymphatic_system0.50906874

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.87063528
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.32272990
3Absent/shortened dynein arms (HP:0200106)9.32272990
4Abnormal respiratory epithelium morphology (HP:0012253)8.97850431
5Abnormal respiratory motile cilium morphology (HP:0005938)8.97850431
6Rhinitis (HP:0012384)8.62004226
7Chronic bronchitis (HP:0004469)6.57801632
8Nasal polyposis (HP:0100582)5.34685589
9Infertility (HP:0000789)5.11646451
10Male infertility (HP:0003251)5.09019167
11Bronchiectasis (HP:0002110)4.99610925
12Abnormality of the nasal mucosa (HP:0000433)4.34382633
13Occipital encephalocele (HP:0002085)3.52892223
14Abnormal biliary tract physiology (HP:0012439)3.51850302
15Bile duct proliferation (HP:0001408)3.51850302
16Tubulointerstitial nephritis (HP:0001970)3.35418873
17Bronchitis (HP:0012387)3.33871280
18True hermaphroditism (HP:0010459)3.33073996
19Medial flaring of the eyebrow (HP:0010747)3.31477916
20Nephronophthisis (HP:0000090)3.30134001
21Pancreatic fibrosis (HP:0100732)3.22780457
22Supernumerary spleens (HP:0009799)2.97665843
23Cystic liver disease (HP:0006706)2.96571230
24Atelectasis (HP:0100750)2.94539981
25Gait imbalance (HP:0002141)2.93751651
26Abnormality of the lower motor neuron (HP:0002366)2.92132602
27Congenital primary aphakia (HP:0007707)2.84971658
28Recurrent sinusitis (HP:0011108)2.77026339
29Chronic otitis media (HP:0000389)2.75297085
30Molar tooth sign on MRI (HP:0002419)2.72858936
31Abnormality of midbrain morphology (HP:0002418)2.72858936
32Abnormality of dentin (HP:0010299)2.70941138
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.70078429
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.70078429
35Postaxial foot polydactyly (HP:0001830)2.69968807
36Recurrent otitis media (HP:0000403)2.67503295
37Hyperactive renin-angiotensin system (HP:0000841)2.59495009
38Nephrogenic diabetes insipidus (HP:0009806)2.53086762
39Pancreatic cysts (HP:0001737)2.50549826
40Chronic sinusitis (HP:0011109)2.50106468
41Congenital hepatic fibrosis (HP:0002612)2.46644886
42Abnormality of the renal medulla (HP:0100957)2.42153159
43Tubulointerstitial abnormality (HP:0001969)2.34102233
44Genetic anticipation (HP:0003743)2.28943146
45Back pain (HP:0003418)2.26820172
46Broad distal phalanx of finger (HP:0009836)2.25434327
47Abnormality of the corticospinal tract (HP:0002492)2.23013895
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.17440245
49Termporal pattern (HP:0011008)2.17391928
50Insidious onset (HP:0003587)2.17391928
51Male pseudohermaphroditism (HP:0000037)2.16700057
52Oculomotor apraxia (HP:0000657)2.08040348
53Poor coordination (HP:0002370)2.06867506
54Vaginal atresia (HP:0000148)2.04493196
55Abnormality of permanent molar morphology (HP:0011071)2.02649827
56Abnormality of the dental root (HP:0006486)2.02649827
57Taurodontia (HP:0000679)2.02649827
58Genital tract atresia (HP:0001827)2.00129026
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0848527
60Abnormal respiratory motile cilium physiology (HP:0012261)10.7562770
61Bell-shaped thorax (HP:0001591)1.95189136
62Short nail (HP:0001799)1.94273387
63Sclerocornea (HP:0000647)1.92699937
64Postaxial hand polydactyly (HP:0001162)1.92061627
65Abnormality of molar (HP:0011077)1.92018541
66Abnormality of molar morphology (HP:0011070)1.92018541
67Amyotrophic lateral sclerosis (HP:0007354)1.90823469
68Hyperkalemia (HP:0002153)1.89187291
69Facial cleft (HP:0002006)1.86872315
70Decreased circulating renin level (HP:0003351)1.86456888
71Tubular atrophy (HP:0000092)1.84332684
72Abnormality of the dental pulp (HP:0006479)1.82122317
73Asplenia (HP:0001746)1.80097446
74Aplasia/Hypoplasia of the lens (HP:0008063)1.79303279
75Median cleft lip (HP:0000161)1.77075192
76Stage 5 chronic kidney disease (HP:0003774)1.76835555
77Renal salt wasting (HP:0000127)1.76831294
78Impaired vibration sensation in the lower limbs (HP:0002166)1.68533249
79Nephropathy (HP:0000112)1.68470697
80Furrowed tongue (HP:0000221)1.67623137
81Fibular hypoplasia (HP:0003038)1.66697045
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.64982094
83Anencephaly (HP:0002323)1.63630592
84Preaxial hand polydactyly (HP:0001177)1.61218176
85Retinal dysplasia (HP:0007973)1.60472471
86Specific learning disability (HP:0001328)1.57442805
87Hand muscle atrophy (HP:0009130)1.56770333
88Hyperaldosteronism (HP:0000859)1.56765332
89Tubulointerstitial fibrosis (HP:0005576)1.55806136
90Agitation (HP:0000713)1.53889979
91Recurrent bronchitis (HP:0002837)1.50739983
92Abnormality of chloride homeostasis (HP:0011422)1.47929219
93Morphological abnormality of the pyramidal tract (HP:0002062)1.46050174
94Chronic hepatic failure (HP:0100626)1.46036026
95Hypotelorism (HP:0000601)1.45933329
96Upper motor neuron abnormality (HP:0002127)1.44824082
97Urinary bladder sphincter dysfunction (HP:0002839)1.44389214
98Abnormality of renin-angiotensin system (HP:0000847)1.43365420
99Hyperglycinuria (HP:0003108)1.39157856
100Abnormality of macular pigmentation (HP:0008002)1.39136448
101Decreased central vision (HP:0007663)1.38549715
102Abnormal umbilical cord blood vessels (HP:0011403)1.36797086
103Single umbilical artery (HP:0001195)1.36797086
104Abnormality of the fetal cardiovascular system (HP:0010948)1.36797086
105Disinhibition (HP:0000734)1.36442998
106Absent frontal sinuses (HP:0002688)1.35601150
107Bifid tongue (HP:0010297)1.35110726
108Retinitis pigmentosa (HP:0000510)1.32375376
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.31187896
110Oral leukoplakia (HP:0002745)1.30227574
111Spontaneous abortion (HP:0005268)1.30145320
112Impaired vibratory sensation (HP:0002495)1.28826858
113Abnormality of glycine metabolism (HP:0010895)1.28542789
114Abnormality of serine family amino acid metabolism (HP:0010894)1.28542789
115Abnormality of the renal cortex (HP:0011035)1.26958005
116Urinary urgency (HP:0000012)1.26046254
117Polydipsia (HP:0001959)1.25805233
118Abnormal drinking behavior (HP:0030082)1.25805233
119Fetal akinesia sequence (HP:0001989)1.25625359
120Prolonged partial thromboplastin time (HP:0003645)1.24734272
121Hypokalemic alkalosis (HP:0001949)1.23985304
122Abnormal rod and cone electroretinograms (HP:0008323)1.22431255
123Hip dysplasia (HP:0001385)1.20036541
124Short thorax (HP:0010306)1.19897356
125Multicystic kidney dysplasia (HP:0000003)1.17374886
126Polyuria (HP:0000103)1.14814034
127Aganglionic megacolon (HP:0002251)1.12467419
128Prominent nasal bridge (HP:0000426)1.11535129
129Abnormality of renal excretion (HP:0011036)1.11246667
130Narrow forehead (HP:0000341)1.08843927
131Cone-rod dystrophy (HP:0000548)1.05756533
132Optic nerve coloboma (HP:0000588)1.01476751
133Absent speech (HP:0001344)1.01231982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.94543754
2PDK45.94543754
3ARAF4.06687202
4MST43.77155443
5MAPK153.70289705
6PDK23.59097750
7EPHA23.45643786
8ICK3.37145652
9PRKD33.25536007
10TESK13.21235279
11PNCK3.19526447
12RIPK12.75199315
13PTK2B2.46607564
14NME12.07252261
15INSRR2.06667021
16EEF2K1.90751305
17BRAF1.89542827
18MAP3K21.71639616
19MET1.64082797
20PIM21.61901416
21GRK11.60563389
22WNK41.57134527
23PLK41.50460727
24ERBB31.47307824
25STK391.46652343
26CDC42BPA1.39396156
27TLK11.35920550
28CDK191.34089792
29CASK1.30382928
30STK381.27390531
31MAPKAPK31.24184334
32OXSR11.22046770
33PRKCG1.21782571
34EPHA31.20460426
35MARK11.20239079
36PHKG21.19705165
37PHKG11.19705165
38EPHA41.09531076
39TYRO31.09530210
40BMPR1B1.04455268
41SMG11.02998631
42DYRK1B1.00526401
43ADRBK20.98044321
44NTRK20.94785029
45EPHB10.91624722
46CAMK1G0.90915118
47BRSK20.90464267
48LATS10.88428005
49NTRK30.87914871
50PRPF4B0.84398856
51PINK10.84083492
52CAMKK10.83536252
53STK240.83214804
54RPS6KA20.82119577
55DYRK1A0.79428603
56MAP3K40.78705041
57BCR0.77751618
58MAP3K30.77217845
59MINK10.76559543
60FRK0.73765594
61MARK20.72397720
62WEE10.70181178
63MAP2K20.68183510
64TAOK10.68112479
65DAPK20.65026823
66GRK50.63953863
67DDR20.63122371
68MAPK130.62845903
69STK160.62772951
70CAMK2G0.61107803
71PDK10.60849823
72PAK60.58519808
73MAP2K40.57890421
74RAF10.55843576
75SGK10.55208374
76PLK10.53689725
77CAMK2B0.52906189
78DYRK20.52716403
79CDK90.52555401
80CAMKK20.52487479
81MAP3K120.51806977
82MAP2K70.51020215
83TSSK60.50800163
84BMPR20.50098161
85NEK20.49861858
86BRSK10.48834757
87CSK0.48742566
88PAK30.48186065
89PDPK10.48129887
90NLK0.46664249
91BMX0.46601772
92DYRK30.44866486
93WNK30.44127505
94WNK10.43183127
95LRRK20.42752415
96MST1R0.41892950
97SGK2230.41449722
98SGK4940.41449722
99KSR10.41325610
100MAP4K20.40692070
101PASK0.39779163
102PRKCQ0.39605819
103TTK0.39369234
104ERBB20.36617145
105PLK20.35893588
106PRKCZ0.35175935
107ADRBK10.34831769
108SIK10.34610842
109STK38L0.34331006
110MAPKAPK50.34234791
111AURKA0.33934476
112CSNK1A1L0.32968197
113TRIB30.32669641
114PRKCD0.32668361
115CAMK2A0.32436750
116TBK10.32010194
117DAPK10.31939442
118CDK50.31667922
119RET0.31423919
120PRKACA0.31406273
121MAP3K90.31360057
122STK110.31054571
123MAP3K70.30978990
124CAMK10.30076031
125CDK120.29851916
126GSK3A0.29571704
127PTK60.28602679
128PRKACG0.28450492
129PRKAA20.27588002
130PRKCA0.26880218
131IRAK10.26416511
132LATS20.26119417
133LMTK20.25377253
134CSNK1G30.25269646
135CDK180.25154252
136FGR0.25128674
137CSNK1G20.24606473
138SGK20.24323304
139MUSK0.24312351
140EPHB20.24027405
141CDK150.22824378
142PRKCE0.22768480
143PRKAA10.22710331
144CDK140.22294577
145MAP3K110.21893665
146PRKG10.21197223
147CCNB10.20376288
148PRKCI0.19820910
149NEK60.18982922
150CAMK2D0.18422370
151PAK10.18283389
152RPS6KA10.16763335
153RPS6KA30.16699114

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.99610222
2Pyruvate metabolism_Homo sapiens_hsa006203.33623359
3Vitamin B6 metabolism_Homo sapiens_hsa007502.87446957
4Propanoate metabolism_Homo sapiens_hsa006402.67410413
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.57230116
6Nitrogen metabolism_Homo sapiens_hsa009102.22300916
7Caffeine metabolism_Homo sapiens_hsa002321.97654297
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.95062477
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89806529
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80294289
11Circadian entrainment_Homo sapiens_hsa047131.69102318
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67277264
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64816505
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63099086
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61101699
16Glucagon signaling pathway_Homo sapiens_hsa049221.60828722
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60082983
18Insulin secretion_Homo sapiens_hsa049111.59732863
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59636017
20Oxidative phosphorylation_Homo sapiens_hsa001901.57251334
21Butanoate metabolism_Homo sapiens_hsa006501.56015083
22Fatty acid biosynthesis_Homo sapiens_hsa000611.55568708
23Arginine biosynthesis_Homo sapiens_hsa002201.53587880
24PPAR signaling pathway_Homo sapiens_hsa033201.51746782
25Sphingolipid metabolism_Homo sapiens_hsa006001.51296633
26Collecting duct acid secretion_Homo sapiens_hsa049661.50048582
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49163738
28Ovarian steroidogenesis_Homo sapiens_hsa049131.45477231
29Fatty acid degradation_Homo sapiens_hsa000711.45059073
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38203161
31GABAergic synapse_Homo sapiens_hsa047271.37368968
32Glutamatergic synapse_Homo sapiens_hsa047241.35433857
33Bile secretion_Homo sapiens_hsa049761.32133039
34Amphetamine addiction_Homo sapiens_hsa050311.31560246
35Phototransduction_Homo sapiens_hsa047441.31289350
36Selenocompound metabolism_Homo sapiens_hsa004501.29396183
37Morphine addiction_Homo sapiens_hsa050321.28012963
38Synaptic vesicle cycle_Homo sapiens_hsa047211.26960374
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.26640230
40Cardiac muscle contraction_Homo sapiens_hsa042601.25156121
41Tryptophan metabolism_Homo sapiens_hsa003801.22286103
42Carbon metabolism_Homo sapiens_hsa012001.18739056
43Chemical carcinogenesis_Homo sapiens_hsa052041.18173247
44Dopaminergic synapse_Homo sapiens_hsa047281.16802210
45Huntingtons disease_Homo sapiens_hsa050161.15542831
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12371338
47Arachidonic acid metabolism_Homo sapiens_hsa005901.09768735
48Parkinsons disease_Homo sapiens_hsa050121.09709754
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09571993
50Complement and coagulation cascades_Homo sapiens_hsa046101.09520975
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09181221
52Regulation of autophagy_Homo sapiens_hsa041401.07991494
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06523268
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04096151
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03588946
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03329354
57Glycerolipid metabolism_Homo sapiens_hsa005611.00761460
58Fatty acid metabolism_Homo sapiens_hsa012121.00743516
59Sulfur metabolism_Homo sapiens_hsa009200.99277721
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99112744
61Taste transduction_Homo sapiens_hsa047420.97637699
62Renin secretion_Homo sapiens_hsa049240.95904468
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95899240
64Long-term potentiation_Homo sapiens_hsa047200.94714292
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88362733
66Peroxisome_Homo sapiens_hsa041460.88339823
67Biosynthesis of amino acids_Homo sapiens_hsa012300.87186684
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86650801
69Histidine metabolism_Homo sapiens_hsa003400.85703191
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82612416
71Alzheimers disease_Homo sapiens_hsa050100.80919836
72Nicotine addiction_Homo sapiens_hsa050330.79365546
73Oocyte meiosis_Homo sapiens_hsa041140.77854076
74beta-Alanine metabolism_Homo sapiens_hsa004100.76376752
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74229227
76Glutathione metabolism_Homo sapiens_hsa004800.74141987
77Calcium signaling pathway_Homo sapiens_hsa040200.73722685
78Phenylalanine metabolism_Homo sapiens_hsa003600.72957315
79Cholinergic synapse_Homo sapiens_hsa047250.72441782
80Dorso-ventral axis formation_Homo sapiens_hsa043200.72120203
81ABC transporters_Homo sapiens_hsa020100.71354601
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69838776
83Gastric acid secretion_Homo sapiens_hsa049710.69743610
84Fat digestion and absorption_Homo sapiens_hsa049750.69543822
85Salivary secretion_Homo sapiens_hsa049700.68951357
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68433115
87Serotonergic synapse_Homo sapiens_hsa047260.67455661
88Circadian rhythm_Homo sapiens_hsa047100.66544795
89Metabolic pathways_Homo sapiens_hsa011000.65555906
90Retinol metabolism_Homo sapiens_hsa008300.64287819
91GnRH signaling pathway_Homo sapiens_hsa049120.63703813
92Estrogen signaling pathway_Homo sapiens_hsa049150.62971297
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62900974
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.60890591
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60869207
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.59460205
97Tyrosine metabolism_Homo sapiens_hsa003500.58408863
98Linoleic acid metabolism_Homo sapiens_hsa005910.57574345
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57533039
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.57085747
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56596188
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56320387
103Cocaine addiction_Homo sapiens_hsa050300.54609921
104Tight junction_Homo sapiens_hsa045300.54294762
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53822641
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.53166365
107Thyroid hormone synthesis_Homo sapiens_hsa049180.53165208
108cAMP signaling pathway_Homo sapiens_hsa040240.52262711
109Prion diseases_Homo sapiens_hsa050200.51622624
110N-Glycan biosynthesis_Homo sapiens_hsa005100.51588451
111Purine metabolism_Homo sapiens_hsa002300.49608852
112Hedgehog signaling pathway_Homo sapiens_hsa043400.47749482
113Arginine and proline metabolism_Homo sapiens_hsa003300.47332335
114Ether lipid metabolism_Homo sapiens_hsa005650.47063614
115Fanconi anemia pathway_Homo sapiens_hsa034600.45620858
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45016542
117Protein export_Homo sapiens_hsa030600.43820732
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42838190
119Vitamin digestion and absorption_Homo sapiens_hsa049770.41319789
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40897653
121RNA polymerase_Homo sapiens_hsa030200.39864506
122Basal cell carcinoma_Homo sapiens_hsa052170.37901104
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.37877988
124Mineral absorption_Homo sapiens_hsa049780.35420940
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35167061
126Starch and sucrose metabolism_Homo sapiens_hsa005000.32747580
127Axon guidance_Homo sapiens_hsa043600.31868705
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30311795
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29206059
130Steroid biosynthesis_Homo sapiens_hsa001000.27743579
131Notch signaling pathway_Homo sapiens_hsa043300.26497896
132Folate biosynthesis_Homo sapiens_hsa007900.26359450
133Vibrio cholerae infection_Homo sapiens_hsa051100.21242059
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20350187
135Nucleotide excision repair_Homo sapiens_hsa034200.20181878
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20111236
137Pancreatic secretion_Homo sapiens_hsa049720.19778549
138Basal transcription factors_Homo sapiens_hsa030220.18475050
139Oxytocin signaling pathway_Homo sapiens_hsa049210.17440882

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