CCDC154

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.97783773
2multicellular organism reproduction (GO:0032504)9.83172972
3binding of sperm to zona pellucida (GO:0007339)9.47978684
4cell-cell recognition (GO:0009988)9.33818260
5cell wall macromolecule metabolic process (GO:0044036)9.30754612
6cell wall macromolecule catabolic process (GO:0016998)9.30754612
7plasma membrane fusion (GO:0045026)9.11508859
8piRNA metabolic process (GO:0034587)8.81620184
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.73878365
10spermatid development (GO:0007286)8.68570092
11cilium movement (GO:0003341)8.61698854
12reproduction (GO:0000003)8.24064101
13male meiosis (GO:0007140)7.74775124
14synaptonemal complex organization (GO:0070193)7.48905502
15regulation of cilium movement (GO:0003352)7.27046334
16synaptonemal complex assembly (GO:0007130)7.20007061
17single fertilization (GO:0007338)6.69643636
18sperm capacitation (GO:0048240)6.39291826
19negative regulation of inclusion body assembly (GO:0090084)6.39004518
20microtubule depolymerization (GO:0007019)6.14890689
21spermatogenesis (GO:0007283)5.93918182
22male gamete generation (GO:0048232)5.91509262
23fertilization (GO:0009566)5.80388883
24gamete generation (GO:0007276)5.43570786
25male meiosis I (GO:0007141)5.41088601
26DNA methylation involved in gamete generation (GO:0043046)5.29954547
27organic cation transport (GO:0015695)5.24528423
28ventricular system development (GO:0021591)5.20858996
29germ cell development (GO:0007281)4.97818578
30chromosome organization involved in meiosis (GO:0070192)4.97653412
31cellular process involved in reproduction in multicellular organism (GO:0022412)4.96174608
32response to peptidoglycan (GO:0032494)4.94921901
33regulation of inclusion body assembly (GO:0090083)4.93439785
34negative regulation of erythrocyte differentiation (GO:0045647)4.84557650
35chromosome condensation (GO:0030261)4.80525420
36seminiferous tubule development (GO:0072520)4.65569562
37neutrophil activation involved in immune response (GO:0002283)4.61532883
38meiotic nuclear division (GO:0007126)4.58817341
39positive regulation of gamma-delta T cell activation (GO:0046645)4.57072346
40DNA packaging (GO:0006323)4.43550651
41meiosis I (GO:0007127)4.39529938
42multicellular organismal reproductive process (GO:0048609)4.26098743
43regulation of microtubule-based movement (GO:0060632)4.22525725
44calcium ion-dependent exocytosis (GO:0017156)4.21056804
45cell recognition (GO:0008037)4.19952761
46meiotic cell cycle (GO:0051321)4.16689503
47response to muramyl dipeptide (GO:0032495)4.15786084
48mannose metabolic process (GO:0006013)4.11043396
49spermatid nucleus differentiation (GO:0007289)4.08234254
50left/right pattern formation (GO:0060972)3.97309415
51negative regulation of interleukin-12 production (GO:0032695)3.88753328
52microtubule severing (GO:0051013)3.87921020
53macrophage activation involved in immune response (GO:0002281)3.76217704
54regulation of mast cell degranulation (GO:0043304)3.74717487
55negative regulation of cell killing (GO:0031342)3.69324746
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69324746
57monoubiquitinated protein deubiquitination (GO:0035520)3.65093406
58immunoglobulin mediated immune response (GO:0016064)3.55675915
59regulation of gamma-delta T cell activation (GO:0046643)3.52715920
60glycerol ether metabolic process (GO:0006662)3.47706946
61protein localization to cilium (GO:0061512)3.47209875
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.42403641
63intraciliary transport (GO:0042073)3.42088272
64nucleoside diphosphate phosphorylation (GO:0006165)3.41501696
65multicellular organismal development (GO:0007275)3.39067668
66regulation of leukocyte degranulation (GO:0043300)3.38162781
67regulation of mast cell activation involved in immune response (GO:0033006)3.37349301
68genitalia morphogenesis (GO:0035112)3.36242790
69chaperone-mediated protein complex assembly (GO:0051131)3.36120282
70protein polyglutamylation (GO:0018095)3.35995425
71regulation of spindle checkpoint (GO:0090231)3.33088882
72positive thymic T cell selection (GO:0045059)3.31301409
73defense response to protozoan (GO:0042832)3.30010010
74axoneme assembly (GO:0035082)3.28722997
75granulocyte activation (GO:0036230)3.25583332
76germinal center formation (GO:0002467)3.25461559
77gene silencing by RNA (GO:0031047)3.22745537
78centriole assembly (GO:0098534)3.20703593
79microtubule-based movement (GO:0007018)3.20505486
80meiotic cell cycle process (GO:1903046)3.20080750
81GTP biosynthetic process (GO:0006183)3.18191721
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18116634
83response to protozoan (GO:0001562)3.17793247
84ether metabolic process (GO:0018904)3.17449791
85detection of bacterium (GO:0016045)3.16001300
86detection of other organism (GO:0098543)3.13616788
87histone H3-K4 trimethylation (GO:0080182)3.12297490
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11053691
89positive regulation by organism of defense response of other organism involved in symbiotic interact3.11053691
90modulation by symbiont of host immune response (GO:0052553)3.11053691
91positive regulation by symbiont of host defense response (GO:0052509)3.11053691
92modulation by symbiont of host defense response (GO:0052031)3.11053691
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11053691
94G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.10094376
95lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09148060
96adenosine receptor signaling pathway (GO:0001973)3.08718127
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06558977
98neutrophil activation (GO:0042119)3.06119595
99N-acetylneuraminate metabolic process (GO:0006054)3.05640494
100microtubule polymerization or depolymerization (GO:0031109)3.05620161
101negative regulation of granulocyte differentiation (GO:0030853)3.04471889
102myeloid cell activation involved in immune response (GO:0002275)3.03782057
103regulation of centriole replication (GO:0046599)3.03143777
104mitotic sister chromatid cohesion (GO:0007064)3.02825077
105regulation of gamma-delta T cell differentiation (GO:0045586)3.01670051
106interferon-gamma-mediated signaling pathway (GO:0060333)2.98418124
107negative regulation of cytokine production involved in immune response (GO:0002719)2.94498993
108cilium organization (GO:0044782)2.94113351
109regulation of B cell receptor signaling pathway (GO:0050855)2.93486903
110centriole replication (GO:0007099)2.91137503
111positive regulation of B cell differentiation (GO:0045579)2.90532518
112synapsis (GO:0007129)2.89527379
113G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.89375843
114amino sugar catabolic process (GO:0046348)2.87707597
115leukocyte aggregation (GO:0070486)2.87412951
116UTP biosynthetic process (GO:0006228)2.86481342
117nucleus organization (GO:0006997)2.84061209
118regulation of mast cell activation (GO:0033003)2.83131905
119single strand break repair (GO:0000012)2.83010470
120negative regulation of innate immune response (GO:0045824)2.82403172
121alditol metabolic process (GO:0019400)2.82388600
122NIK/NF-kappaB signaling (GO:0038061)2.81847988
123carnitine transport (GO:0015879)2.81615063
124amino-acid betaine transport (GO:0015838)2.81615063
125CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81199683
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.81055786
127regulation of T-helper 2 cell differentiation (GO:0045628)2.80736623
128protein refolding (GO:0042026)2.80600752
129regulation of regulated secretory pathway (GO:1903305)2.80420344
130antigen processing and presentation of endogenous antigen (GO:0019883)2.80265288
131negative regulation of organelle assembly (GO:1902116)2.79507338
132carnitine transmembrane transport (GO:1902603)2.78465605
133positive regulation of mast cell activation involved in immune response (GO:0033008)2.78266614
134positive regulation of mast cell degranulation (GO:0043306)2.78266614
135regulation of interferon-beta biosynthetic process (GO:0045357)2.78072222
136cilium assembly (GO:0042384)2.76638787
137glycolytic process (GO:0006096)2.74918587
138negative regulation of tumor necrosis factor production (GO:0032720)2.74546833
139detection of external biotic stimulus (GO:0098581)2.74352280
140activation of JUN kinase activity (GO:0007257)2.73943886
141interferon-gamma secretion (GO:0072643)2.73320724
142natural killer cell mediated immunity (GO:0002228)2.72472007
143natural killer cell mediated cytotoxicity (GO:0042267)2.72472007
144positive regulation of mast cell activation (GO:0033005)2.72327568
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72068168
146regulation of protein polyubiquitination (GO:1902914)2.71373424
147cellular response to exogenous dsRNA (GO:0071360)2.70095939
148regulation of ARF GTPase activity (GO:0032312)2.67977522
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67607195
150negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.67313621
151sexual reproduction (GO:0019953)2.67183050
152cellular component assembly involved in morphogenesis (GO:0010927)2.67067025
153regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.66461565
154cilium morphogenesis (GO:0060271)2.65804955
155negative regulation of interleukin-8 production (GO:0032717)2.65484471
156positive regulation of protein kinase C signaling (GO:0090037)2.65311074
157B cell receptor signaling pathway (GO:0050853)2.64540858
158leukocyte degranulation (GO:0043299)2.63437913
159nuclear pore complex assembly (GO:0051292)2.63437453
160regulation of antigen processing and presentation (GO:0002577)2.62547328
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.61755265
162regulation of T-helper 1 cell differentiation (GO:0045625)2.61523079
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61233298
164regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60774580
165negative regulation of toll-like receptor signaling pathway (GO:0034122)2.59858974
166regulation of tumor necrosis factor production (GO:0032680)2.59257103
167protein K11-linked deubiquitination (GO:0035871)2.57919169
168positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.56810632
169regulation of podosome assembly (GO:0071801)2.56763662
170thymic T cell selection (GO:0045061)2.56579418
171UTP metabolic process (GO:0046051)2.55854641
172regulation of cilium assembly (GO:1902017)2.55501942
173response to type I interferon (GO:0034340)2.55419364
174macrophage activation (GO:0042116)2.55215793
175positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.54591179
176detection of molecule of bacterial origin (GO:0032490)2.54349607
177T cell selection (GO:0045058)2.54338654
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53887225
179purinergic receptor signaling pathway (GO:0035587)2.53182897
180mature B cell differentiation involved in immune response (GO:0002313)2.53021819
181modulation by virus of host process (GO:0019054)2.52944298
182cellular response to arsenic-containing substance (GO:0071243)2.52862308
183purinergic nucleotide receptor signaling pathway (GO:0035590)2.52628878
184regulation of interferon-beta production (GO:0032648)2.52240830
185modulation by symbiont of host cellular process (GO:0044068)2.52239227
186Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51503662
187regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51118928
188negative regulation of type I interferon production (GO:0032480)2.50392089
189positive regulation of antigen processing and presentation (GO:0002579)2.50278491
190phosphatidylglycerol biosynthetic process (GO:0006655)2.49827960
191positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.48927008
192type I interferon signaling pathway (GO:0060337)2.47839735
193cilium or flagellum-dependent cell motility (GO:0001539)13.5402178
194sperm motility (GO:0030317)12.0890839
195fusion of sperm to egg plasma membrane (GO:0007342)12.0430427
196axonemal dynein complex assembly (GO:0070286)11.1965237
197acrosome assembly (GO:0001675)10.5072327
198acrosome reaction (GO:0007340)10.3312941
199sperm-egg recognition (GO:0035036)10.2900512
200motile cilium assembly (GO:0044458)10.1311205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.45376363
2VDR_21846776_ChIP-Seq_THP-1_Human4.06214587
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41417585
4EZH2_22144423_ChIP-Seq_EOC_Human3.32352790
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.28374696
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.07631829
7MYC_22102868_ChIP-Seq_BL_Human2.88596277
8* LXR_22292898_ChIP-Seq_THP-1_Human2.86958738
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.78336010
10VDR_24763502_ChIP-Seq_THP-1_Human2.71011394
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.47104070
12TCF7_22412390_ChIP-Seq_EML_Mouse2.43201454
13KDM2B_26808549_Chip-Seq_DND41_Human2.38765825
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37267081
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34778733
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.33813346
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31267571
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.30761480
19SCL_19346495_ChIP-Seq_HPC-7_Human2.24899158
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21372851
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18247438
22MAF_26560356_Chip-Seq_TH1_Human2.16174967
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15998065
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14728987
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.12637640
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08315721
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06768657
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05791415
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04826006
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.04280089
31MAF_26560356_Chip-Seq_TH2_Human2.03204535
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00166670
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0862505
34* P68_20966046_ChIP-Seq_HELA_Human1.98973567
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.94604784
36UTX_26944678_Chip-Seq_JUKART_Human1.93747265
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.86971216
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84981089
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.82943910
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81448048
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80572977
42BCL6_27268052_Chip-Seq_Bcells_Human1.78734336
43RACK7_27058665_Chip-Seq_MCF-7_Human1.77084323
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76597826
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75749463
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.75522760
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73633508
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73033843
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72537746
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68223749
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66075344
52DROSHA_22980978_ChIP-Seq_HELA_Human1.65946134
53KDM2B_26808549_Chip-Seq_K562_Human1.65867764
54STAT1_17558387_ChIP-Seq_HELA_Human1.62976586
55SPI1_23127762_ChIP-Seq_K562_Human1.61522002
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.60165036
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.57494093
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56952383
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54987659
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.51998671
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.49317202
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48677592
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48051646
64SPI1_23547873_ChIP-Seq_NB4_Human1.46192661
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45502466
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.44515804
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42445521
68ZNF274_21170338_ChIP-Seq_K562_Hela1.41671373
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.39636422
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38092226
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.36273601
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35720186
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.35282080
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35206554
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35173314
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35140391
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34111264
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.33976466
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32738804
80* E2F1_20622854_ChIP-Seq_HELA_Human1.32441122
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32012256
82CREB1_26743006_Chip-Seq_LNCaP_Human1.31868972
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29493282
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29473347
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29230827
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28836160
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27979682
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27352881
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27287854
90GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.27122930
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26504285
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.25736962
93NCOR1_26117541_ChIP-Seq_K562_Human1.24944420
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24707589
95* CTCF_27219007_Chip-Seq_Bcells_Human1.23598199
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.23037301
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22885418
98WDR5_24793694_ChIP-Seq_LNCAP_Human1.22492579
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22204001
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21687856
101* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21108056
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.19972646
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19701878
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18023607
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17478218
106* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17349395
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15975708
108P53_21459846_ChIP-Seq_SAOS-2_Human1.15667768
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13791822
110STAT1_20625510_ChIP-Seq_HELA_Human1.12904464
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12841795
112CIITA_25753668_ChIP-Seq_RAJI_Human1.12758708
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12562525
114STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12219523
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12084228
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11991874
117KDM2B_26808549_Chip-Seq_REH_Human1.11845146
118CBP_20019798_ChIP-Seq_JUKART_Human1.10901730
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10901730
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09964785
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.09817699
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09629833
123GATA1_19941826_ChIP-Seq_K562_Human1.09605519
124OCT4_19829295_ChIP-Seq_ESCs_Human1.09394649
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.08203571
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.07859614
127VDR_22108803_ChIP-Seq_LS180_Human1.07479534
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06883742
129GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05663531
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05355559
131RUNX_20019798_ChIP-Seq_JUKART_Human1.05180232
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.05046473
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04837082
134RARB_24833708_ChIP-Seq_LIVER_Mouse1.04314506
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04121641
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04029360
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03996248
138SA1_27219007_Chip-Seq_Bcells_Human1.03895506
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03520215
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03468945
141CTCF_21964334_Chip-Seq_Bcells_Human1.03332947
142SPI1_26923725_Chip-Seq_HPCs_Mouse1.03307479
143GF1_26923725_Chip-Seq_HPCs_Mouse1.03231383
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02735906
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02206425
146GATA3_21867929_ChIP-Seq_TH1_Mouse1.01646493
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01439326
148RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00723084
149BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00539738
150RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00307082
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99885934
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99534104
153FLI1_21867929_ChIP-Seq_TH2_Mouse0.98559365
154ERG_20517297_ChIP-Seq_VCAP_Human0.96940256
155SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96199772
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95378267
157LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95011192
158RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93941797
159RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93247854
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.92913939
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92865700
162CTCF_26484167_Chip-Seq_Bcells_Mouse0.91518326
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.90937936
164* ELF1_20517297_ChIP-Seq_JURKAT_Human0.90826377
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.90742335
166BCOR_27268052_Chip-Seq_Bcells_Human0.90102986
167EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87918382
168TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87774835
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87774835
170VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87376633
171PHF8_20622854_ChIP-Seq_HELA_Human0.86864016
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85774750
173SOX2_21211035_ChIP-Seq_LN229_Human0.85368275
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84774822
175CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84457301
176YY1_22570637_ChIP-Seq_MALME-3M_Human0.84282895
177SOX11_22085726_ChIP-Seq_ESNs_Mouse0.84192967
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82988400
179CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82158568
180LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81251167
181SMC4_20622854_ChIP-Seq_HELA_Human0.80576303
182JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80508271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.56663976
2MP0001929_abnormal_gametogenesis5.12718220
3MP0008877_abnormal_DNA_methylation4.05447550
4MP0002210_abnormal_sex_determination3.33731826
5MP0002161_abnormal_fertility/fecundity3.04322130
6MP0001145_abnormal_male_reproductive2.82810660
7MP0003724_increased_susceptibility_to2.58438312
8MP0006082_CNS_inflammation2.57262079
9MP0005000_abnormal_immune_tolerance2.45521688
10MP0000653_abnormal_sex_gland2.41070271
11MP0005623_abnormal_meninges_morphology2.34457241
12MP0002148_abnormal_hypersensitivity_rea2.32023217
13MP0005409_darkened_coat_color2.25882629
14MP0005671_abnormal_response_to2.06767781
15MP0002653_abnormal_ependyma_morphology2.02141911
16MP0005451_abnormal_body_composition2.01209757
17MP0005410_abnormal_fertilization14.5673353
18MP0000569_abnormal_digit_pigmentation1.89202137
19MP0008995_early_reproductive_senescence1.82066298
20MP0009840_abnormal_foam_cell1.79039033
21MP0009764_decreased_sensitivity_to1.77516974
22MP0004510_myositis1.72666374
23MP0001986_abnormal_taste_sensitivity1.71442214
24MP0002822_catalepsy1.68122458
25MP0005310_abnormal_salivary_gland1.66543059
26MP0004381_abnormal_hair_follicle1.64766885
27MP0005076_abnormal_cell_differentiation1.61131817
28MP0005670_abnormal_white_adipose1.55568189
29MP0003763_abnormal_thymus_physiology1.55548136
30MP0003300_gastrointestinal_ulcer1.54410150
31MP0001533_abnormal_skeleton_physiology1.51588870
32MP0002160_abnormal_reproductive_system1.47008318
33MP0003183_abnormal_peptide_metabolism1.44872306
34MP0009333_abnormal_splenocyte_physiolog1.43768321
35MP0010094_abnormal_chromosome_stability1.43251628
36MP0002998_abnormal_bone_remodeling1.42670968
37MP0001873_stomach_inflammation1.38709527
38MP0005167_abnormal_blood-brain_barrier1.34438591
39MP0009278_abnormal_bone_marrow1.33665744
40MP0003656_abnormal_erythrocyte_physiolo1.27846025
41MP0002282_abnormal_trachea_morphology1.27768582
42MP0004858_abnormal_nervous_system1.27326760
43MP0002429_abnormal_blood_cell1.24555660
44MP0001545_abnormal_hematopoietic_system1.23805344
45MP0005397_hematopoietic_system_phenotyp1.23805344
46MP0000858_altered_metastatic_potential1.21542924
47MP0003453_abnormal_keratinocyte_physiol1.15016921
48MP0003136_yellow_coat_color1.13217021
49MP0002722_abnormal_immune_system1.10448427
50MP0002933_joint_inflammation1.10059951
51MP0003690_abnormal_glial_cell1.09959334
52MP0003075_altered_response_to1.09557647
53MP0001853_heart_inflammation1.08932120
54MP0008058_abnormal_DNA_repair1.08858716
55MP0004233_abnormal_muscle_weight1.08065058
56MP0004808_abnormal_hematopoietic_stem1.07034417
57MP0003786_premature_aging1.06467140
58MP0010234_abnormal_vibrissa_follicle1.04324220
59MP0010307_abnormal_tumor_latency1.03748917
60MP0005464_abnormal_platelet_physiology1.03736661
61MP0002396_abnormal_hematopoietic_system1.01691576
62MP0001765_abnormal_ion_homeostasis0.99484901
63MP0005647_abnormal_sex_gland0.99014150
64MP0001851_eye_inflammation0.98950033
65MP0004185_abnormal_adipocyte_glucose0.95384174
66MP0003111_abnormal_nucleus_morphology0.94607580
67MP0002928_abnormal_bile_duct0.94480929
68MP0004130_abnormal_muscle_cell0.90583963
69MP0000681_abnormal_thyroid_gland0.90002882
70MP0000703_abnormal_thymus_morphology0.89613993
71MP0003646_muscle_fatigue0.89056568
72MP0005083_abnormal_biliary_tract0.88229316
73MP0003879_abnormal_hair_cell0.87621071
74MP0001958_emphysema0.85656923
75MP0003303_peritoneal_inflammation0.84929035
76MP0003806_abnormal_nucleotide_metabolis0.83638539
77MP0008057_abnormal_DNA_replication0.81689442
78MP0000604_amyloidosis0.81321609
79MP0002405_respiratory_system_inflammati0.79760959
80MP0005666_abnormal_adipose_tissue0.79433825
81MP0005171_absent_coat_pigmentation0.78299053
82MP0005174_abnormal_tail_pigmentation0.77677855
83MP0001663_abnormal_digestive_system0.77026603
84MP0003279_aneurysm0.76885645
85MP0000747_muscle_weakness0.76612984
86MP0003115_abnormal_respiratory_system0.76298749
87MP0000343_altered_response_to0.74562945
88MP0002166_altered_tumor_susceptibility0.74390221
89MP0008874_decreased_physiological_sensi0.74290403
90MP0005423_abnormal_somatic_nervous0.72498127
91MP0005535_abnormal_body_temperature0.71461469
92MP0003077_abnormal_cell_cycle0.71374186
93MP0009046_muscle_twitch0.71085824
94MP0003329_amyloid_beta_deposits0.70791334
95MP0005058_abnormal_lysosome_morphology0.70554423
96MP0003866_abnormal_defecation0.69681525
97MP0005389_reproductive_system_phenotype0.69515878
98MP0002254_reproductive_system_inflammat0.68054289
99MP0006054_spinal_hemorrhage0.67794823
100MP0004264_abnormal_extraembryonic_tissu0.65889278
101MP0002419_abnormal_innate_immunity0.65689312
102MP0001849_ear_inflammation0.64866761
103MP0003705_abnormal_hypodermis_morpholog0.64709018
104MP0008004_abnormal_stomach_pH0.64546364
105MP0001542_abnormal_bone_strength0.64427293
106MP0003091_abnormal_cell_migration0.63595767
107MP0005448_abnormal_energy_balance0.63039062
108MP0003878_abnormal_ear_physiology0.62401760
109MP0005377_hearing/vestibular/ear_phenot0.62401760
110MP0001348_abnormal_lacrimal_gland0.62334047
111MP0002132_abnormal_respiratory_system0.61616401
112MP0008007_abnormal_cellular_replicative0.61551149
113MP0002796_impaired_skin_barrier0.61168210
114MP0001661_extended_life_span0.60644877
115MP0000358_abnormal_cell_content/0.58324690
116MP0003252_abnormal_bile_duct0.57696788
117MP0003045_fibrosis0.57689319
118MP0005388_respiratory_system_phenotype0.54227051
119MP0002133_abnormal_respiratory_system0.54227051
120MP0003693_abnormal_embryo_hatching0.54206036
121MP0000015_abnormal_ear_pigmentation0.53197903
122MP0005025_abnormal_response_to0.51868440
123MP0003436_decreased_susceptibility_to0.51501630
124MP0002723_abnormal_immune_serum0.51009972
125MP0001790_abnormal_immune_system0.50286829
126MP0005387_immune_system_phenotype0.50286829
127MP0003172_abnormal_lysosome_physiology0.49128472
128MP0001730_embryonic_growth_arrest0.43859169
129MP0003699_abnormal_female_reproductive0.43467250
130MP0008469_abnormal_protein_level0.43053086
131MP0008260_abnormal_autophagy0.43012042
132MP0000249_abnormal_blood_vessel0.42860669
133MP0003950_abnormal_plasma_membrane0.42656215
134MP0003448_altered_tumor_morphology0.42031189
135MP0002452_abnormal_antigen_presenting0.41336540
136MP0003567_abnormal_fetal_cardiomyocyte0.40279151
137MP0010155_abnormal_intestine_physiology0.39781071
138MP0005636_abnormal_mineral_homeostasis0.39627579
139MP0004947_skin_inflammation0.38101937
140MP0000313_abnormal_cell_death0.37456256
141MP0001835_abnormal_antigen_presentation0.37043370
142MP0004782_abnormal_surfactant_physiolog0.36772577
143MP0003191_abnormal_cellular_cholesterol0.36536340
144MP0001175_abnormal_lung_morphology0.35956888
145MP0001293_anophthalmia0.35204008
146MP0001819_abnormal_immune_cell0.34902167
147MP0002420_abnormal_adaptive_immunity0.34838035
148MP0001845_abnormal_inflammatory_respons0.34438217
149MP0000685_abnormal_immune_system0.33661313
150MP0002398_abnormal_bone_marrow0.33625373
151MP0001764_abnormal_homeostasis0.33427951
152MP0008961_abnormal_basal_metabolism0.32406463
153MP0003221_abnormal_cardiomyocyte_apopto0.32248752
154MP0009785_altered_susceptibility_to0.31819295
155MP0001800_abnormal_humoral_immune0.31112157
156MP0000689_abnormal_spleen_morphology0.30931215
157MP0001984_abnormal_olfaction0.30488167
158MP0005380_embryogenesis_phenotype0.30043513
159MP0001672_abnormal_embryogenesis/_devel0.30043513
160MP0000716_abnormal_immune_system0.29368476

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.32419252
2Abnormal respiratory epithelium morphology (HP:0012253)8.73400609
3Abnormal respiratory motile cilium morphology (HP:0005938)8.73400609
4Rhinitis (HP:0012384)7.72236869
5Chronic bronchitis (HP:0004469)7.54090588
6Abnormal ciliary motility (HP:0012262)7.49965624
7Nasal polyposis (HP:0100582)7.24928927
8Abnormality of the nasal mucosa (HP:0000433)6.07569435
9Infertility (HP:0000789)5.96724749
10Bronchiectasis (HP:0002110)4.84814631
11Bronchitis (HP:0012387)4.70578585
12Increased cerebral lipofuscin (HP:0011813)4.35315917
13Abnormality of glycolipid metabolism (HP:0010969)4.17013817
14Abnormality of liposaccharide metabolism (HP:0010968)4.17013817
15Abnormality of glycosphingolipid metabolism (HP:0004343)4.17013817
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.96133839
17Abnormality of macrophages (HP:0004311)3.92142113
18Thin bony cortex (HP:0002753)3.90436090
19Nephronophthisis (HP:0000090)3.86896572
20Dysostosis multiplex (HP:0000943)3.83591629
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.35466639
22Recurrent otitis media (HP:0000403)3.27131203
23Male infertility (HP:0003251)3.24617689
24Tubulointerstitial nephritis (HP:0001970)3.19859176
25Recurrent sinusitis (HP:0011108)3.15327281
26Abnormality of polysaccharide metabolism (HP:0011012)3.14918264
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.14918264
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.14918264
29Chronic obstructive pulmonary disease (HP:0006510)3.11584823
30Obstructive lung disease (HP:0006536)3.11584823
31Obstructive sleep apnea (HP:0002870)3.09852483
32Mucopolysacchariduria (HP:0008155)3.08412211
33Urinary glycosaminoglycan excretion (HP:0003541)3.08412211
34Abnormality of the renal medulla (HP:0100957)3.05321680
35Myositis (HP:0100614)3.03143173
36Chronic mucocutaneous candidiasis (HP:0002728)3.00667598
37Recurrent cutaneous fungal infections (HP:0011370)3.00667598
38Recurrent fungal infections (HP:0002841)2.96640037
39Abnormality of the lower motor neuron (HP:0002366)2.94443751
40Systemic lupus erythematosus (HP:0002725)2.84053137
41Abnormality of the fingertips (HP:0001211)2.82331450
42Recurrent bronchitis (HP:0002837)2.81570582
43Mediastinal lymphadenopathy (HP:0100721)2.76664037
44Stomatitis (HP:0010280)2.73418494
45Recurrent skin infections (HP:0001581)2.71107804
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.67634004
47Meningitis (HP:0001287)2.65766039
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.64135079
49Autoimmune thrombocytopenia (HP:0001973)2.63337827
50J-shaped sella turcica (HP:0002680)2.63125494
51Tubulointerstitial abnormality (HP:0001969)2.62956317
52Abnormal spermatogenesis (HP:0008669)2.62574123
53Orchitis (HP:0100796)2.61735690
54Tubular atrophy (HP:0000092)2.57689225
55Gastrointestinal inflammation (HP:0004386)2.55219083
56Thoracic kyphosis (HP:0002942)2.54953196
57Gastrointestinal infarctions (HP:0005244)2.54617427
58Vacuolated lymphocytes (HP:0001922)2.54324744
59Elevated erythrocyte sedimentation rate (HP:0003565)2.52611556
60Panhypogammaglobulinemia (HP:0003139)2.49519931
61Chronic otitis media (HP:0000389)2.47759691
62Tubulointerstitial fibrosis (HP:0005576)2.46619130
63Global brain atrophy (HP:0002283)2.45137542
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44346740
65Pustule (HP:0200039)2.43868735
66Increased IgE level (HP:0003212)2.43702926
67Increased serum ferritin (HP:0003281)2.43593795
68Hemoptysis (HP:0002105)2.42885547
69Impulsivity (HP:0100710)2.42340701
70Disinhibition (HP:0000734)2.41857820
71Cerebral aneurysm (HP:0004944)2.39949444
72Gingivitis (HP:0000230)2.39676798
73Inflammation of the large intestine (HP:0002037)2.39438431
74Recurrent viral infections (HP:0004429)2.38183300
75Chest pain (HP:0100749)2.35452488
76Cellulitis (HP:0100658)2.32585222
77Genetic anticipation (HP:0003743)2.31503038
78Neuronal loss in central nervous system (HP:0002529)2.31136448
79Abnormality of binocular vision (HP:0011514)2.30257143
80Diplopia (HP:0000651)2.30257143
81Nuclear cataract (HP:0100018)2.30183226
82Broad face (HP:0000283)2.28100719
83Supranuclear gaze palsy (HP:0000605)2.28083305
84Pulmonary infiltrates (HP:0002113)2.27543294
85Gonadotropin excess (HP:0000837)2.27499766
86Annular pancreas (HP:0001734)2.20852769
87Molar tooth sign on MRI (HP:0002419)2.20352264
88Abnormality of midbrain morphology (HP:0002418)2.20352264
89Spontaneous hematomas (HP:0007420)2.18680520
90Restrictive lung disease (HP:0002091)2.18227723
91Joint stiffness (HP:0001387)2.17751935
92Amyotrophic lateral sclerosis (HP:0007354)2.14624794
93Asymmetric septal hypertrophy (HP:0001670)2.12866888
94Abnormality of the thoracic spine (HP:0100711)2.12532103
95Spastic tetraparesis (HP:0001285)2.12389003
96Neurofibrillary tangles (HP:0002185)2.12369869
97Visual hallucinations (HP:0002367)2.12243029
98Vasculitis (HP:0002633)2.09955181
99Epistaxis (HP:0000421)2.09306414
100Abnormality of iron homeostasis (HP:0011031)2.07454169
101Fibular hypoplasia (HP:0003038)2.06664734
102Encephalitis (HP:0002383)2.03625875
103Recurrent bacterial skin infections (HP:0005406)2.02104372
104Hepatosplenomegaly (HP:0001433)2.01862803
105Purpura (HP:0000979)2.00295066
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0234863
107Absent/shortened dynein arms (HP:0200106)12.5075330
108Dynein arm defect of respiratory motile cilia (HP:0012255)12.5075330
109Prolonged bleeding time (HP:0003010)1.99828555
110Axonal loss (HP:0003447)1.99283461
111Recurrent abscess formation (HP:0002722)1.98157901
112Agammaglobulinemia (HP:0004432)1.97405760
113Deformed sella turcica (HP:0002681)1.95071027
114Chronic sinusitis (HP:0011109)1.94511272
115Hypophosphatemia (HP:0002148)1.92450776
116Flat acetabular roof (HP:0003180)1.88714484
117Stage 5 chronic kidney disease (HP:0003774)1.88411633
118Absent frontal sinuses (HP:0002688)1.88378272
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88235267
120Absent epiphyses (HP:0010577)1.88235267
121Testicular atrophy (HP:0000029)1.88165298
122Easy fatigability (HP:0003388)1.87051950
123Acute lymphatic leukemia (HP:0006721)1.84630630
124Emphysema (HP:0002097)1.84610857
125Metaphyseal cupping (HP:0003021)1.83294342
126Upper motor neuron abnormality (HP:0002127)1.83037230
127Azoospermia (HP:0000027)1.81408682
128Congenital stationary night blindness (HP:0007642)1.80398940
129Flat occiput (HP:0005469)1.78965736
130Mutism (HP:0002300)1.78845498
131Petechiae (HP:0000967)1.78775196
132Heterotopia (HP:0002282)1.77598478
133Broad distal phalanx of finger (HP:0009836)1.77278784
134Abnormality of lateral ventricle (HP:0030047)1.76614579
135Diminished motivation (HP:0000745)1.76131268
136Hypochromic anemia (HP:0001931)1.76056799
137Polygenic inheritance (HP:0010982)1.75984245
138Turricephaly (HP:0000262)1.74946603
139Medial flaring of the eyebrow (HP:0010747)1.67060038
140Postaxial foot polydactyly (HP:0001830)1.65619524
141Short nail (HP:0001799)1.65199820
142Abnormality of the anterior horn cell (HP:0006802)1.64788289
143Degeneration of anterior horn cells (HP:0002398)1.64788289
144Choroideremia (HP:0001139)1.64051926
145Abnormality of the renal cortex (HP:0011035)1.62278818
146Bell-shaped thorax (HP:0001591)1.57723101
147Eczematoid dermatitis (HP:0000976)1.52875751
148Abnormality of the dental root (HP:0006486)1.51355416
149Taurodontia (HP:0000679)1.51355416
150Abnormality of permanent molar morphology (HP:0011071)1.51355416
151Abnormal gallbladder physiology (HP:0012438)1.49790234
152Cholecystitis (HP:0001082)1.49790234
153Oculomotor apraxia (HP:0000657)1.45478239
154Recurrent gram-negative bacterial infections (HP:0005420)1.44075591
155Congenital hepatic fibrosis (HP:0002612)1.41317566
156Abnormality of dentin (HP:0010299)1.38995724
157Abnormality of molar (HP:0011077)1.38362449
158Abnormality of molar morphology (HP:0011070)1.38362449
159Abnormality of the sella turcica (HP:0002679)1.36980911
160Cystic liver disease (HP:0006706)1.35987862
161Osteolytic defects of the hand bones (HP:0009699)1.34813830
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.34813830
163Abnormality of the dental pulp (HP:0006479)1.33820348
164Impaired proprioception (HP:0010831)1.32551742
165Short ribs (HP:0000773)1.29640245
166Abnormality of renal excretion (HP:0011036)1.28514008
167Polydipsia (HP:0001959)1.24049111
168Abnormal drinking behavior (HP:0030082)1.24049111
169Conjunctival telangiectasia (HP:0000524)1.23440353
170Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.21790380
171Loss of speech (HP:0002371)1.20069718
172Supernumerary spleens (HP:0009799)1.19877318
173Hypoplasia of dental enamel (HP:0006297)1.19523242
174Aplasia/Hypoplasia of the fibula (HP:0006492)1.18492961
175Dyschromatopsia (HP:0007641)1.18416699
176Nephropathy (HP:0000112)1.16989431
177Hemorrhage of the eye (HP:0011885)1.16887576
178Retrobulbar optic neuritis (HP:0100654)1.15918907
179Optic neuritis (HP:0100653)1.15918907
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.15762397
18111 pairs of ribs (HP:0000878)1.14726432
182Short thorax (HP:0010306)1.13370111
183Pancreatic fibrosis (HP:0100732)1.13080939
184Short femoral neck (HP:0100864)1.11537671
185Glucose intolerance (HP:0000833)1.08920121
186Difficulty climbing stairs (HP:0003551)1.08415380
187Abnormality of saccadic eye movements (HP:0000570)1.08351345
188Postaxial hand polydactyly (HP:0001162)1.08084759
189Renal dysplasia (HP:0000110)1.07220827
190Colitis (HP:0002583)1.06571832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.06045506
2PDK48.06045506
3PDK26.24998082
4TESK15.32865807
5ICK3.56957532
6PRKD33.33195083
7TNK23.09436249
8ERN12.92254009
9PTK2B2.49652060
10PNCK2.47280388
11SIK22.41276974
12NEK22.24401678
13PRPF4B2.23427497
14SIK12.19548359
15MAP3K112.05484767
16IRAK31.97696449
17STK391.91734400
18CAMK1D1.86555950
19WNK41.69634296
20CCNB11.66709471
21STK381.49274760
22DYRK1B1.37662306
23NME21.30522857
24INSRR1.30100870
25MAP3K131.28512578
26SIK31.22398803
27CAMKK21.20778732
28PRKD21.20086973
29RIPK11.19690927
30CDC42BPA1.17969453
31IKBKE1.15337322
32IKBKB1.14326057
33PDK11.13132121
34TAOK21.13099700
35JAK31.11644143
36RPS6KC11.08155376
37RPS6KL11.08155376
38MAP3K11.06464159
39MAP3K141.06041495
40MATK1.04786024
41MAPK151.02862839
42HIPK21.00725821
43RPS6KA60.97116533
44RPS6KA20.95226680
45MAP3K60.90188327
46TEC0.87400626
47LYN0.86687490
48IRAK20.84795161
49WNK10.81200966
50MAP3K70.81007918
51STK30.77657777
52MOS0.77527485
53SMG10.76150563
54RIPK40.75908156
55BMX0.74742863
56DYRK30.73232681
57FGFR40.72047288
58MAP4K10.70815306
59WEE10.70728424
60PDPK10.70580574
61FGR0.67286769
62TXK0.66753669
63CAMK1G0.66706328
64TAOK30.66419881
65PRKCH0.64944769
66JAK20.60193302
67DAPK20.59906838
68PTK60.59495294
69CDC70.58324338
70JAK10.58290913
71STK100.58152871
72CDK120.56344350
73STK110.56303166
74PASK0.56141766
75TESK20.54529655
76DDR20.53662814
77BTK0.53335450
78ITK0.53129259
79EEF2K0.52959496
80PAK40.52495564
81CAMK40.50873435
82PAK10.48384994
83ATR0.48055980
84CAMK10.46577634
85ZAP700.45421852
86MTOR0.45027439
87CHEK10.44989720
88GRK70.44709115
89MAPK120.44587818
90IRAK40.44326699
91ACVR1B0.44248251
92CDK60.43085391
93TTK0.41135897
94SGK30.41060871
95NEK60.40947948
96CDK40.40865469
97EPHB10.40741860
98FES0.39213185
99BCKDK0.38726235
100TBK10.38500215
101CHEK20.37742317
102PLK10.36868055
103MAP2K20.36844719
104TRIB30.36524435
105PINK10.35093625
106PKN10.35081873
107PRKAA20.34910025
108MAPK80.34378229
109ATM0.33328681
110PRKCQ0.33261899
111MAP3K30.30794380
112CSF1R0.30566133
113CSK0.30508251
114PLK40.29921637
115TAOK10.29209860
116TYK20.28502465
117IRAK10.28412066
118MARK30.27562123
119PIM10.25340104
120TTN0.25023388
121AURKB0.23769556
122STK38L0.23481991
123KIT0.23226841
124BRSK10.23147759
125PAK20.22807600
126EGFR0.21720491
127MAP2K60.21701635
128TYRO30.20857672
129YES10.20491063
130MARK20.19349190
131PIK3CG0.18366849
132EPHA20.17668768
133CAMKK10.17303804
134BUB10.16487051
135PRKAA10.16246093
136GRK60.14698361
137LCK0.13105002
138BRSK20.12623016
139TGFBR20.12326649
140MAPK40.11353413
141TRPM70.11215745
142SYK0.10963057
143CHUK0.08690593
144GSK3A0.08512675
145LRRK20.08311559
146BLK0.07822250
147MAP2K30.06658463
148PRKCD0.06621350
149PIM20.06425589
150PKN20.06113579
151LMTK20.05694716
152HCK0.05545985
153CDK10.05482186
154PRKCG0.05352155

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.11225979
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.74913471
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.63574145
4Other glycan degradation_Homo sapiens_hsa005113.34243724
5Fatty acid biosynthesis_Homo sapiens_hsa000613.27132825
6Pyruvate metabolism_Homo sapiens_hsa006202.66118605
7Selenocompound metabolism_Homo sapiens_hsa004502.61493654
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49464015
9Pentose phosphate pathway_Homo sapiens_hsa000302.44949758
10Linoleic acid metabolism_Homo sapiens_hsa005912.41235179
11Allograft rejection_Homo sapiens_hsa053302.27514124
12Asthma_Homo sapiens_hsa053102.26429599
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.21185840
14Glucagon signaling pathway_Homo sapiens_hsa049222.14657753
15Basal transcription factors_Homo sapiens_hsa030222.14050103
16Graft-versus-host disease_Homo sapiens_hsa053321.98783210
17Dorso-ventral axis formation_Homo sapiens_hsa043201.93996164
18Autoimmune thyroid disease_Homo sapiens_hsa053201.92686813
19Fanconi anemia pathway_Homo sapiens_hsa034601.91608011
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91417555
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90832741
22Lysosome_Homo sapiens_hsa041421.90282437
23Propanoate metabolism_Homo sapiens_hsa006401.88403218
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.85311019
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.83360875
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77789688
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74338133
28Notch signaling pathway_Homo sapiens_hsa043301.72202809
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67426035
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66333505
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.65202858
32Oocyte meiosis_Homo sapiens_hsa041141.64593148
33B cell receptor signaling pathway_Homo sapiens_hsa046621.60031213
34Glycerolipid metabolism_Homo sapiens_hsa005611.58895648
35Type I diabetes mellitus_Homo sapiens_hsa049401.46173555
36Antigen processing and presentation_Homo sapiens_hsa046121.44203903
37Rheumatoid arthritis_Homo sapiens_hsa053231.42033462
38Ether lipid metabolism_Homo sapiens_hsa005651.39225766
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32465860
40Fructose and mannose metabolism_Homo sapiens_hsa000511.31803826
41Hematopoietic cell lineage_Homo sapiens_hsa046401.29002196
42TNF signaling pathway_Homo sapiens_hsa046681.28427549
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24185615
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21035479
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20151851
46Glutathione metabolism_Homo sapiens_hsa004801.19249556
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19151312
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11502454
49Chemokine signaling pathway_Homo sapiens_hsa040621.11239992
50Pertussis_Homo sapiens_hsa051331.09140301
51PPAR signaling pathway_Homo sapiens_hsa033201.08443598
52Viral myocarditis_Homo sapiens_hsa054161.07390900
53mRNA surveillance pathway_Homo sapiens_hsa030151.06432379
54Fat digestion and absorption_Homo sapiens_hsa049751.05951261
55Mineral absorption_Homo sapiens_hsa049781.04692948
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.03354527
57ABC transporters_Homo sapiens_hsa020101.02814742
58mTOR signaling pathway_Homo sapiens_hsa041501.02713015
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01393408
60Chronic myeloid leukemia_Homo sapiens_hsa052200.99887147
61Arachidonic acid metabolism_Homo sapiens_hsa005900.96460854
62Osteoclast differentiation_Homo sapiens_hsa043800.94721654
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93218762
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.92886339
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.91888960
66RNA transport_Homo sapiens_hsa030130.91169015
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90407808
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90305362
69Hepatitis B_Homo sapiens_hsa051610.89775833
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.89278163
71Platelet activation_Homo sapiens_hsa046110.88874011
72Purine metabolism_Homo sapiens_hsa002300.88586494
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.88297488
74Non-small cell lung cancer_Homo sapiens_hsa052230.88036308
75Carbon metabolism_Homo sapiens_hsa012000.87991042
76Legionellosis_Homo sapiens_hsa051340.86288554
77Bladder cancer_Homo sapiens_hsa052190.86024058
78Collecting duct acid secretion_Homo sapiens_hsa049660.85348266
79Huntingtons disease_Homo sapiens_hsa050160.80895687
80Influenza A_Homo sapiens_hsa051640.80049288
81Prolactin signaling pathway_Homo sapiens_hsa049170.78799800
82Amphetamine addiction_Homo sapiens_hsa050310.78563057
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78190614
84African trypanosomiasis_Homo sapiens_hsa051430.77466445
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76466743
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76171080
87VEGF signaling pathway_Homo sapiens_hsa043700.75400826
88GnRH signaling pathway_Homo sapiens_hsa049120.74899903
89Choline metabolism in cancer_Homo sapiens_hsa052310.73892010
90Measles_Homo sapiens_hsa051620.72067712
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.71525093
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.70988089
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70911941
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70406998
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69484039
96Type II diabetes mellitus_Homo sapiens_hsa049300.68335796
97Toxoplasmosis_Homo sapiens_hsa051450.67742013
98MAPK signaling pathway_Homo sapiens_hsa040100.67420176
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67152315
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66482813
101Pancreatic cancer_Homo sapiens_hsa052120.64512054
102Insulin resistance_Homo sapiens_hsa049310.63594374
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60964034
104Base excision repair_Homo sapiens_hsa034100.60921241
105Systemic lupus erythematosus_Homo sapiens_hsa053220.60593511
106FoxO signaling pathway_Homo sapiens_hsa040680.59758817
107HTLV-I infection_Homo sapiens_hsa051660.58991136
108Renin secretion_Homo sapiens_hsa049240.58728908
109Estrogen signaling pathway_Homo sapiens_hsa049150.58725538
110Apoptosis_Homo sapiens_hsa042100.57047532
111Regulation of autophagy_Homo sapiens_hsa041400.56553232
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56549603
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.56161343
114Amoebiasis_Homo sapiens_hsa051460.53985497
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.53982054
116Thyroid hormone synthesis_Homo sapiens_hsa049180.53231527
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53138801
118Lysine degradation_Homo sapiens_hsa003100.52741300
119Viral carcinogenesis_Homo sapiens_hsa052030.52325634
120Renal cell carcinoma_Homo sapiens_hsa052110.51617792
121Homologous recombination_Homo sapiens_hsa034400.48133128
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47086084
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46994222
124ErbB signaling pathway_Homo sapiens_hsa040120.46987580
125Epstein-Barr virus infection_Homo sapiens_hsa051690.46583298
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46277552
127Renin-angiotensin system_Homo sapiens_hsa046140.46201407
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45809121
129Vitamin digestion and absorption_Homo sapiens_hsa049770.45698446
130Endocytosis_Homo sapiens_hsa041440.45650577
131Insulin signaling pathway_Homo sapiens_hsa049100.45466154
132Inositol phosphate metabolism_Homo sapiens_hsa005620.45124674
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44145345
134Phagosome_Homo sapiens_hsa041450.44049136
135Biosynthesis of amino acids_Homo sapiens_hsa012300.44015516
136T cell receptor signaling pathway_Homo sapiens_hsa046600.42934140
137Shigellosis_Homo sapiens_hsa051310.41207896
138Salmonella infection_Homo sapiens_hsa051320.40526029
139Fatty acid metabolism_Homo sapiens_hsa012120.40409710
140Cholinergic synapse_Homo sapiens_hsa047250.40149625
141Fatty acid degradation_Homo sapiens_hsa000710.38548844
142Primary immunodeficiency_Homo sapiens_hsa053400.38150203
143Cardiac muscle contraction_Homo sapiens_hsa042600.38043846
144AMPK signaling pathway_Homo sapiens_hsa041520.37608435
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37114646
146Chemical carcinogenesis_Homo sapiens_hsa052040.36514523
147Acute myeloid leukemia_Homo sapiens_hsa052210.36406947
148Cell cycle_Homo sapiens_hsa041100.34257027
149Hepatitis C_Homo sapiens_hsa051600.33842982
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33145621
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32041287
152Herpes simplex infection_Homo sapiens_hsa051680.31773019
153HIF-1 signaling pathway_Homo sapiens_hsa040660.31348690
154Tuberculosis_Homo sapiens_hsa051520.30844485
155Small cell lung cancer_Homo sapiens_hsa052220.30712770
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.30294324
157Malaria_Homo sapiens_hsa051440.30058132
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27563530
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25752225
160Leishmaniasis_Homo sapiens_hsa051400.25028427
161Sphingolipid metabolism_Homo sapiens_hsa006000.23789241
162Staphylococcus aureus infection_Homo sapiens_hsa051500.23306094

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