CCDC157

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.20644645
2sensory perception of smell (GO:0007608)5.73166479
3behavioral response to nicotine (GO:0035095)5.29269067
4axonemal dynein complex assembly (GO:0070286)4.84662708
5cilium movement (GO:0003341)4.52962257
6epithelial cilium movement (GO:0003351)4.48356292
7protein localization to cilium (GO:0061512)4.30223800
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.15242487
9acrosome reaction (GO:0007340)3.87919960
10motile cilium assembly (GO:0044458)3.85087469
11sensory perception of chemical stimulus (GO:0007606)3.72723163
12multicellular organism reproduction (GO:0032504)3.69430380
13intraciliary transport (GO:0042073)3.62409791
14sperm motility (GO:0030317)3.57649092
15regulation of cilium movement (GO:0003352)3.56936336
16axoneme assembly (GO:0035082)3.56714511
17fusion of sperm to egg plasma membrane (GO:0007342)3.53786872
18kynurenine metabolic process (GO:0070189)3.49773226
19L-fucose catabolic process (GO:0042355)3.44586193
20fucose catabolic process (GO:0019317)3.44586193
21L-fucose metabolic process (GO:0042354)3.44586193
22indole-containing compound catabolic process (GO:0042436)3.43113559
23indolalkylamine catabolic process (GO:0046218)3.43113559
24tryptophan catabolic process (GO:0006569)3.43113559
25indolalkylamine metabolic process (GO:0006586)3.41282379
26preassembly of GPI anchor in ER membrane (GO:0016254)3.39088060
27cellular ketone body metabolic process (GO:0046950)3.35044198
28cell wall macromolecule metabolic process (GO:0044036)3.31849485
29cell wall macromolecule catabolic process (GO:0016998)3.31849485
30response to pheromone (GO:0019236)3.30656593
31microtubule bundle formation (GO:0001578)3.30100442
32mannosylation (GO:0097502)3.28981473
33base-excision repair, AP site formation (GO:0006285)3.26200008
34nonmotile primary cilium assembly (GO:0035058)3.24267118
35negative regulation of telomere maintenance (GO:0032205)3.20117804
36acrosome assembly (GO:0001675)3.18960529
37centriole replication (GO:0007099)3.18589582
38water-soluble vitamin biosynthetic process (GO:0042364)3.16554038
39protein complex biogenesis (GO:0070271)3.14480831
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13969134
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13969134
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.13253936
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11973352
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.11973352
45NADH dehydrogenase complex assembly (GO:0010257)3.11973352
46DNA deamination (GO:0045006)3.10379077
47calcium ion-dependent exocytosis (GO:0017156)3.07127947
48respiratory chain complex IV assembly (GO:0008535)3.06849634
49protein polyglutamylation (GO:0018095)3.06779009
50tryptophan metabolic process (GO:0006568)3.06504078
51plasma membrane fusion (GO:0045026)3.03608817
52male meiosis (GO:0007140)3.01412139
53ubiquinone biosynthetic process (GO:0006744)3.01314771
54pyrimidine nucleobase catabolic process (GO:0006208)3.00712850
55vocalization behavior (GO:0071625)3.00288323
56ketone body metabolic process (GO:1902224)2.99393539
57cornea development in camera-type eye (GO:0061303)2.97604155
58cilium assembly (GO:0042384)2.95385917
59reproduction (GO:0000003)2.95376021
60cilium organization (GO:0044782)2.92752887
61synaptic transmission, cholinergic (GO:0007271)2.92364810
62mitochondrial respiratory chain complex assembly (GO:0033108)2.92052235
63centriole assembly (GO:0098534)2.89297998
64piRNA metabolic process (GO:0034587)2.89192448
65GPI anchor metabolic process (GO:0006505)2.87096376
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.86705922
67ubiquinone metabolic process (GO:0006743)2.83663994
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80558990
69glutamate secretion (GO:0014047)2.80424803
70cytochrome complex assembly (GO:0017004)2.80378901
71sperm-egg recognition (GO:0035036)2.79459485
72microtubule severing (GO:0051013)2.78017196
73regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76556960
74nucleoside diphosphate phosphorylation (GO:0006165)2.76214449
75detection of light stimulus involved in visual perception (GO:0050908)2.74646380
76detection of light stimulus involved in sensory perception (GO:0050962)2.74646380
77ventricular system development (GO:0021591)2.74558536
78retinal cone cell development (GO:0046549)2.74164400
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73265125
80response to auditory stimulus (GO:0010996)2.72406997
81neural tube formation (GO:0001841)2.72248235
82single fertilization (GO:0007338)2.68954511
83cellular biogenic amine catabolic process (GO:0042402)2.66957876
84amine catabolic process (GO:0009310)2.66957876
85determination of left/right symmetry (GO:0007368)2.66855841
86membrane depolarization during action potential (GO:0086010)2.66429463
87cell projection assembly (GO:0030031)2.66197231
88neuron cell-cell adhesion (GO:0007158)2.66006131
89cilium morphogenesis (GO:0060271)2.65923350
90GTP biosynthetic process (GO:0006183)2.65484490
91platelet dense granule organization (GO:0060155)2.62386099
92dendritic spine morphogenesis (GO:0060997)2.62043489
93lung epithelium development (GO:0060428)2.60653682
94regulation of synaptic vesicle exocytosis (GO:2000300)2.60530997
95regulation of collateral sprouting (GO:0048670)2.60032344
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59589107
97photoreceptor cell development (GO:0042461)2.59377292
98organic cation transport (GO:0015695)2.59324874
99gamma-aminobutyric acid transport (GO:0015812)2.58732041
100iron-sulfur cluster assembly (GO:0016226)2.58650010
101metallo-sulfur cluster assembly (GO:0031163)2.58650010
102lactate metabolic process (GO:0006089)2.58477773
103detection of calcium ion (GO:0005513)2.54068514
104left/right pattern formation (GO:0060972)2.53683617
105male meiosis I (GO:0007141)2.53560445
106axonal fasciculation (GO:0007413)2.52912833
107regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52299389
108GPI anchor biosynthetic process (GO:0006506)2.50857016
109determination of bilateral symmetry (GO:0009855)2.49758035
110regulation of synaptic vesicle transport (GO:1902803)2.48885579
111neurotransmitter-gated ion channel clustering (GO:0072578)2.48663060
112protein-cofactor linkage (GO:0018065)2.48152518
113C-terminal protein lipidation (GO:0006501)2.47670197
114reciprocal DNA recombination (GO:0035825)2.47531386
115reciprocal meiotic recombination (GO:0007131)2.47531386
116pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46843813
117synaptic vesicle endocytosis (GO:0048488)2.46153692
118photoreceptor cell maintenance (GO:0045494)2.46102754
119appendage development (GO:0048736)2.45892326
120limb development (GO:0060173)2.45892326
121glycolipid biosynthetic process (GO:0009247)2.45873000
122indole-containing compound metabolic process (GO:0042430)2.45821267
123cell-cell recognition (GO:0009988)2.45191817
124calcium ion import (GO:0070509)2.44593058
125nucleobase catabolic process (GO:0046113)2.44112798
126postsynaptic membrane organization (GO:0001941)2.43235512
127synaptonemal complex organization (GO:0070193)2.42400096
128cellular component assembly involved in morphogenesis (GO:0010927)2.41405070
129specification of symmetry (GO:0009799)2.41019324
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41014984
131positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41008990
132benzene-containing compound metabolic process (GO:0042537)2.40305212
133regulation of action potential (GO:0098900)2.39676657
134regulation of meiosis I (GO:0060631)2.39367433
135spermatid development (GO:0007286)2.38820010
136establishment of nucleus localization (GO:0040023)2.35681569
137dendrite morphogenesis (GO:0048813)2.34737183
138binding of sperm to zona pellucida (GO:0007339)2.31740508
139neuron recognition (GO:0008038)2.29980731
140cerebellar Purkinje cell differentiation (GO:0021702)2.29863408
141innervation (GO:0060384)2.29166669
142peptidyl-glutamic acid modification (GO:0018200)2.28718026
143chemical homeostasis within a tissue (GO:0048875)2.27870838
144regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27648861
145photoreceptor cell differentiation (GO:0046530)2.27189649
146eye photoreceptor cell differentiation (GO:0001754)2.27189649
147locomotory exploration behavior (GO:0035641)2.26075372
148cAMP catabolic process (GO:0006198)2.25685834
149protein localization to synapse (GO:0035418)2.25413373
150regulation of glutamate receptor signaling pathway (GO:1900449)2.25375213
151neurotransmitter secretion (GO:0007269)2.24801203
152olfactory bulb development (GO:0021772)2.24248194
153auditory behavior (GO:0031223)2.23615461
154central nervous system projection neuron axonogenesis (GO:0021952)2.21783806
155phosphorelay signal transduction system (GO:0000160)2.21448484
156regulation of chromatin binding (GO:0035561)2.19658876
157DNA methylation involved in gamete generation (GO:0043046)2.18306610
158regulation of microtubule-based movement (GO:0060632)2.17985581
159activation of protein kinase A activity (GO:0034199)2.17813139
160chemosensory behavior (GO:0007635)2.17607066
161regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17524439
162smoothened signaling pathway (GO:0007224)2.17423225
163neuronal ion channel clustering (GO:0045161)2.16956969
164neuron projection extension involved in neuron projection guidance (GO:1902284)2.16878891
165axon extension involved in axon guidance (GO:0048846)2.16878891
166synaptonemal complex assembly (GO:0007130)2.16433270
167striatum development (GO:0021756)2.16131081
168negative regulation of astrocyte differentiation (GO:0048712)2.14709151
169left/right axis specification (GO:0070986)2.14665480
170female mating behavior (GO:0060180)2.13671635
171fertilization (GO:0009566)2.13646630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05910836
2VDR_22108803_ChIP-Seq_LS180_Human3.09714407
3GBX2_23144817_ChIP-Seq_PC3_Human2.81745967
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57072934
5IGF1R_20145208_ChIP-Seq_DFB_Human2.51485650
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35570162
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33244012
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.06492553
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00821588
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00546678
11DROSHA_22980978_ChIP-Seq_HELA_Human2.00464198
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97362419
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95553244
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94144646
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94012685
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91459454
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90285262
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90285262
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.88470379
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87667424
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87642112
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85260706
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83393396
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.82606613
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.80755272
26FUS_26573619_Chip-Seq_HEK293_Human1.79612105
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76563938
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74975025
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73995303
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73645905
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.73437709
32ER_23166858_ChIP-Seq_MCF-7_Human1.72402612
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.70566078
34EWS_26573619_Chip-Seq_HEK293_Human1.65691205
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64785382
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.58226194
37REST_21632747_ChIP-Seq_MESCs_Mouse1.57944211
38TAF15_26573619_Chip-Seq_HEK293_Human1.57844115
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55906817
40TP53_22573176_ChIP-Seq_HFKS_Human1.55542375
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52923917
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52490717
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51780590
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.49829543
45SMAD4_21799915_ChIP-Seq_A2780_Human1.49417081
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47306519
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44361946
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43083899
49CBP_20019798_ChIP-Seq_JUKART_Human1.43079898
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43079898
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.42374656
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42363481
53BCAT_22108803_ChIP-Seq_LS180_Human1.41382936
54IRF1_19129219_ChIP-ChIP_H3396_Human1.40904464
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40394735
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40064320
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.39370747
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38831930
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38175034
60AHR_22903824_ChIP-Seq_MCF-7_Human1.37896725
61NCOR_22424771_ChIP-Seq_293T_Human1.36769145
62HOXB7_26014856_ChIP-Seq_BT474_Human1.36674358
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36649069
64MYC_18940864_ChIP-ChIP_HL60_Human1.36017507
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.35692259
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35692259
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35562278
68RNF2_27304074_Chip-Seq_NSC_Mouse1.35303514
69ERA_21632823_ChIP-Seq_H3396_Human1.34987849
70P300_19829295_ChIP-Seq_ESCs_Human1.34975423
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33855932
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33187009
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31910588
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31910588
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30394539
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30279475
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.29846608
78MYC_19829295_ChIP-Seq_ESCs_Human1.29382990
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29343787
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.26971788
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24287665
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23836425
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22685569
84NANOG_19829295_ChIP-Seq_ESCs_Human1.22457876
85SOX2_19829295_ChIP-Seq_ESCs_Human1.22457876
86VDR_23849224_ChIP-Seq_CD4+_Human1.22411509
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.21895319
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21870895
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21226414
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21059862
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20546370
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19328072
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19124819
94* NANOG_20526341_ChIP-Seq_ESCs_Human1.18909194
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18908523
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18626283
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18005127
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.17979083
99OCT4_20526341_ChIP-Seq_ESCs_Human1.17870970
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17179134
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.17089088
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16094749
103RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15787248
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15682611
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15535627
106TCF4_22108803_ChIP-Seq_LS180_Human1.15388368
107AR_20517297_ChIP-Seq_VCAP_Human1.14671059
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13481007
109STAT3_23295773_ChIP-Seq_U87_Human1.13230657
110TAF2_19829295_ChIP-Seq_ESCs_Human1.11826825
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11459643
112TCF4_23295773_ChIP-Seq_U87_Human1.11142210
113* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10027543
114CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09965713
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09874275
116AR_25329375_ChIP-Seq_VCAP_Human1.09033286
117P53_22387025_ChIP-Seq_ESCs_Mouse1.08907697
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.08513100
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08098845
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07187286
121SMAD_19615063_ChIP-ChIP_OVARY_Human1.06879517
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06562827
123ETS1_20019798_ChIP-Seq_JURKAT_Human1.06006630
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05889700
125RUNX2_22187159_ChIP-Seq_PCA_Human1.05864247
126REST_18959480_ChIP-ChIP_MESCs_Mouse1.04189724
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.03910068
128* P53_21459846_ChIP-Seq_SAOS-2_Human1.03833557
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03374831
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01978120
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01335939
132NFE2_27457419_Chip-Seq_LIVER_Mouse1.01039175
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00708061
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00575399
135EP300_21415370_ChIP-Seq_HL-1_Mouse1.00381081
136KDM2B_26808549_Chip-Seq_REH_Human0.99988976
137* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99079978
138ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98935271
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98234816
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97918450
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97870626
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96920634
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.96336875
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.95707144
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.95319791
146AR_19668381_ChIP-Seq_PC3_Human0.94893409
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94801921
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.93701399
149P300_18555785_Chip-Seq_ESCs_Mouse0.93452518
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.93005367
151ZNF274_21170338_ChIP-Seq_K562_Hela0.92678415
152TP53_18474530_ChIP-ChIP_U2OS_Human0.92637058
153EZH2_27294783_Chip-Seq_NPCs_Mouse0.91664532
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.91582995
155TAL1_26923725_Chip-Seq_HPCs_Mouse0.91210473
156RARB_27405468_Chip-Seq_BRAIN_Mouse0.91066522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.65000657
2MP0005410_abnormal_fertilization3.50936939
3MP0005645_abnormal_hypothalamus_physiol3.16452604
4MP0005646_abnormal_pituitary_gland2.77344525
5MP0008875_abnormal_xenobiotic_pharmacok2.58232876
6MP0004133_heterotaxia2.54405012
7MP0003136_yellow_coat_color2.46337375
8MP0002837_dystrophic_cardiac_calcinosis2.39278724
9MP0004859_abnormal_synaptic_plasticity2.31474238
10MP0005394_taste/olfaction_phenotype2.26821750
11MP0005499_abnormal_olfactory_system2.26821750
12MP0000566_synostosis2.23843547
13MP0002653_abnormal_ependyma_morphology2.17536276
14MP0002638_abnormal_pupillary_reflex2.07870447
15MP0005551_abnormal_eye_electrophysiolog2.07316279
16MP0003787_abnormal_imprinting2.02988339
17MP0009780_abnormal_chondrocyte_physiolo2.02424396
18MP0008789_abnormal_olfactory_epithelium2.01059699
19MP0003635_abnormal_synaptic_transmissio2.00212027
20MP0003646_muscle_fatigue1.92591876
21MP0005423_abnormal_somatic_nervous1.88200710
22MP0005377_hearing/vestibular/ear_phenot1.87450809
23MP0003878_abnormal_ear_physiology1.87450809
24MP0005623_abnormal_meninges_morphology1.82525316
25MP0001486_abnormal_startle_reflex1.79449469
26MP0000778_abnormal_nervous_system1.78990851
27MP0001986_abnormal_taste_sensitivity1.77824540
28MP0006072_abnormal_retinal_apoptosis1.75610985
29MP0004270_analgesia1.70929970
30MP0002063_abnormal_learning/memory/cond1.70484612
31MP0001529_abnormal_vocalization1.68634534
32MP0003195_calcinosis1.67321307
33MP0006292_abnormal_olfactory_placode1.65997059
34MP0002184_abnormal_innervation1.65099050
35MP0009745_abnormal_behavioral_response1.65053207
36MP0008872_abnormal_physiological_respon1.64346504
37MP0009046_muscle_twitch1.63555013
38MP0004142_abnormal_muscle_tone1.63038926
39MP0002102_abnormal_ear_morphology1.62687509
40MP0002734_abnormal_mechanical_nocicepti1.61624877
41MP0004858_abnormal_nervous_system1.58395722
42MP0003011_delayed_dark_adaptation1.52265159
43MP0000372_irregular_coat_pigmentation1.50442638
44MP0002557_abnormal_social/conspecific_i1.50177816
45MP0003698_abnormal_male_reproductive1.48011310
46MP0003879_abnormal_hair_cell1.47945661
47MP0001485_abnormal_pinna_reflex1.47689820
48MP0002064_seizures1.45876145
49MP0002572_abnormal_emotion/affect_behav1.45610493
50MP0001968_abnormal_touch/_nociception1.43231683
51MP0003880_abnormal_central_pattern1.42097998
52MP0002736_abnormal_nociception_after1.40219689
53MP0002272_abnormal_nervous_system1.37260444
54MP0006276_abnormal_autonomic_nervous1.35338757
55MP0001502_abnormal_circadian_rhythm1.34250124
56MP0004147_increased_porphyrin_level1.34022420
57MP0003121_genomic_imprinting1.32359334
58MP0000569_abnormal_digit_pigmentation1.31290778
59MP0003283_abnormal_digestive_organ1.30811468
60MP0002160_abnormal_reproductive_system1.29771259
61MP0002067_abnormal_sensory_capabilities1.29050769
62MP0000026_abnormal_inner_ear1.26686964
63MP0001970_abnormal_pain_threshold1.26358079
64MP0002277_abnormal_respiratory_mucosa1.26175178
65MP0005503_abnormal_tendon_morphology1.25398615
66MP0001919_abnormal_reproductive_system1.23458005
67MP0004885_abnormal_endolymph1.23058721
68MP0001501_abnormal_sleep_pattern1.22269523
69MP0000631_abnormal_neuroendocrine_gland1.21699989
70MP0008995_early_reproductive_senescence1.21224586
71MP0002938_white_spotting1.19397444
72MP0002882_abnormal_neuron_morphology1.17450001
73MP0004742_abnormal_vestibular_system1.16454907
74MP0001177_atelectasis1.15729267
75MP0001963_abnormal_hearing_physiology1.15081344
76MP0002752_abnormal_somatic_nervous1.14644313
77MP0001270_distended_abdomen1.13162315
78MP0002234_abnormal_pharynx_morphology1.09254561
79MP0002733_abnormal_thermal_nociception1.09028046
80MP0008877_abnormal_DNA_methylation1.09024819
81MP0005253_abnormal_eye_physiology1.07335405
82MP0004782_abnormal_surfactant_physiolog1.06714341
83MP0002233_abnormal_nose_morphology1.06104783
84MP0002928_abnormal_bile_duct1.06087207
85MP0001764_abnormal_homeostasis1.06014187
86MP0010386_abnormal_urinary_bladder1.05850502
87MP0002089_abnormal_postnatal_growth/wei1.05331885
88MP0002108_abnormal_muscle_morphology1.01726529
89MP0005084_abnormal_gallbladder_morpholo0.99407302
90MP0002909_abnormal_adrenal_gland0.97834774
91MP0001929_abnormal_gametogenesis0.97772491
92MP0005174_abnormal_tail_pigmentation0.97569895
93MP0003942_abnormal_urinary_system0.97363586
94MP0002282_abnormal_trachea_morphology0.97118512
95MP0005171_absent_coat_pigmentation0.96678149
96MP0009697_abnormal_copulation0.96550804
97MP0001299_abnormal_eye_distance/0.95914998
98MP0003122_maternal_imprinting0.95905954
99MP0003938_abnormal_ear_development0.94967191
100MP0002138_abnormal_hepatobiliary_system0.92705577
101MP0005670_abnormal_white_adipose0.92176129
102MP0005167_abnormal_blood-brain_barrier0.91221516
103MP0001905_abnormal_dopamine_level0.90975734
104MP0005365_abnormal_bile_salt0.90834191
105MP0002163_abnormal_gland_morphology0.90829665
106MP0002152_abnormal_brain_morphology0.89752807
107MP0003137_abnormal_impulse_conducting0.89413716
108MP0008058_abnormal_DNA_repair0.89238420
109MP0004134_abnormal_chest_morphology0.88214501
110MP0000427_abnormal_hair_cycle0.87701555
111MP0000653_abnormal_sex_gland0.85758947
112MP0000383_abnormal_hair_follicle0.84437691
113MP0001145_abnormal_male_reproductive0.83971141
114MP0002735_abnormal_chemical_nociception0.83962124
115MP0002876_abnormal_thyroid_physiology0.83829156
116MP0004924_abnormal_behavior0.82835171
117MP0005386_behavior/neurological_phenoty0.82835171
118MP0008569_lethality_at_weaning0.82755782
119MP0003633_abnormal_nervous_system0.81887656
120MP0005389_reproductive_system_phenotype0.81183789
121MP0000955_abnormal_spinal_cord0.81137642
122MP0005083_abnormal_biliary_tract0.81105549
123MP0002210_abnormal_sex_determination0.79473022
124MP0003718_maternal_effect0.78943512
125MP0005195_abnormal_posterior_eye0.77676107
126MP0002132_abnormal_respiratory_system0.77590284
127MP0002139_abnormal_hepatobiliary_system0.76476595
128MP0004811_abnormal_neuron_physiology0.75690326
129MP0000049_abnormal_middle_ear0.75662218
130MP0005367_renal/urinary_system_phenotyp0.75072963
131MP0000516_abnormal_urinary_system0.75072963
132MP0001440_abnormal_grooming_behavior0.74283765
133MP0002161_abnormal_fertility/fecundity0.73882256
134MP0009250_abnormal_appendicular_skeleto0.72556015
135MP0001188_hyperpigmentation0.71723358
136MP0002229_neurodegeneration0.71192941
137MP0002822_catalepsy0.69946024
138MP0001324_abnormal_eye_pigmentation0.69903957
139MP0002066_abnormal_motor_capabilities/c0.68768979
140MP0004043_abnormal_pH_regulation0.68424059

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.73019031
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.32664198
3Absent/shortened dynein arms (HP:0200106)6.32664198
4Abnormal respiratory motile cilium physiology (HP:0012261)5.56485257
5Abnormal ciliary motility (HP:0012262)5.17520761
6Abnormal respiratory epithelium morphology (HP:0012253)5.12408062
7Abnormal respiratory motile cilium morphology (HP:0005938)5.12408062
8Rhinitis (HP:0012384)4.23662979
9Chronic bronchitis (HP:0004469)3.57956093
10Central scotoma (HP:0000603)3.32001555
11Nephronophthisis (HP:0000090)3.30989756
12Type II lissencephaly (HP:0007260)3.12686160
13Focal motor seizures (HP:0011153)3.11359896
14Febrile seizures (HP:0002373)3.04401554
15Medial flaring of the eyebrow (HP:0010747)3.03530986
16Molar tooth sign on MRI (HP:0002419)2.95546011
17Abnormality of midbrain morphology (HP:0002418)2.95546011
18Anosmia (HP:0000458)2.95372779
19Tubular atrophy (HP:0000092)2.89222077
20Abnormality of the renal cortex (HP:0011035)2.86650427
21Abnormality of the renal medulla (HP:0100957)2.86165503
22Anencephaly (HP:0002323)2.84220137
23True hermaphroditism (HP:0010459)2.81934240
24Gait imbalance (HP:0002141)2.79545557
25Bell-shaped thorax (HP:0001591)2.75505793
26Congenital primary aphakia (HP:0007707)2.75426669
27Abnormality of macular pigmentation (HP:0008002)2.69492691
28Sclerocornea (HP:0000647)2.67983384
29Bony spicule pigmentary retinopathy (HP:0007737)2.61639944
30Nephrogenic diabetes insipidus (HP:0009806)2.60884040
31Decreased central vision (HP:0007663)2.56962493
32Bronchiectasis (HP:0002110)2.56443845
33Occipital encephalocele (HP:0002085)2.52662791
34Male pseudohermaphroditism (HP:0000037)2.50936747
35Attenuation of retinal blood vessels (HP:0007843)2.48820974
36Focal seizures (HP:0007359)2.44362554
37Atonic seizures (HP:0010819)2.41020995
38Chronic hepatic failure (HP:0100626)2.39394798
39Abnormal rod and cone electroretinograms (HP:0008323)2.38524579
40Postaxial hand polydactyly (HP:0001162)2.32373907
41Pancreatic fibrosis (HP:0100732)2.32017314
42Dyschromatopsia (HP:0007641)2.31772006
43Tubulointerstitial nephritis (HP:0001970)2.27194163
44Cerebellar dysplasia (HP:0007033)2.27076335
45Aplasia/Hypoplasia of the lens (HP:0008063)2.25409534
46Infertility (HP:0000789)2.24657247
47Postaxial foot polydactyly (HP:0001830)2.24323977
48Pendular nystagmus (HP:0012043)2.24035902
49Cystic liver disease (HP:0006706)2.21918803
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.21290734
51Absence seizures (HP:0002121)2.20195028
52Vitreoretinal degeneration (HP:0000655)2.15968582
53Polyuria (HP:0000103)2.15889368
54Scotoma (HP:0000575)2.14347861
55Fibular hypoplasia (HP:0003038)2.13481753
56Hypothermia (HP:0002045)2.10848629
57Genital tract atresia (HP:0001827)2.09570382
58Polydipsia (HP:0001959)2.09301065
59Abnormal drinking behavior (HP:0030082)2.09301065
60Epileptic encephalopathy (HP:0200134)2.08273612
61Congenital hepatic fibrosis (HP:0002612)2.07183917
62Lissencephaly (HP:0001339)2.06387192
63Vaginal atresia (HP:0000148)2.05773157
64Abnormality of dentin (HP:0010299)2.05577086
65Asplenia (HP:0001746)2.04746369
66Abolished electroretinogram (ERG) (HP:0000550)2.04629398
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03613744
68Retinitis pigmentosa (HP:0000510)2.03137590
69Preaxial hand polydactyly (HP:0001177)2.02910790
70Furrowed tongue (HP:0000221)2.02739607
71Bifid tongue (HP:0010297)2.00671377
72Bradycardia (HP:0001662)1.99254080
733-Methylglutaconic aciduria (HP:0003535)1.98231370
74Renovascular hypertension (HP:0100817)1.96510849
75Poor coordination (HP:0002370)1.96253550
76Absent speech (HP:0001344)1.94928356
77Congenital stationary night blindness (HP:0007642)1.93808765
78Mitochondrial inheritance (HP:0001427)1.93595397
79Chronic sinusitis (HP:0011109)1.92615961
80Acute necrotizing encephalopathy (HP:0006965)1.91735489
81Stage 5 chronic kidney disease (HP:0003774)1.90693648
82Median cleft lip (HP:0000161)1.90255724
83Hyperventilation (HP:0002883)1.90055328
84Tubulointerstitial abnormality (HP:0001969)1.89041151
85Atelectasis (HP:0100750)1.87540511
86Elfin facies (HP:0004428)1.86325536
87Recurrent sinusitis (HP:0011108)1.85389203
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85218394
89Nasal polyposis (HP:0100582)1.84846503
90Abnormality of the labia minora (HP:0012880)1.84317008
91Generalized tonic-clonic seizures (HP:0002069)1.83882636
92Abnormal biliary tract physiology (HP:0012439)1.83853392
93Bile duct proliferation (HP:0001408)1.83853392
94Aplasia involving bones of the upper limbs (HP:0009823)1.82711556
95Aplasia of the phalanges of the hand (HP:0009802)1.82711556
96Aplasia involving bones of the extremities (HP:0009825)1.82711556
97Decreased circulating renin level (HP:0003351)1.82125770
98Constricted visual fields (HP:0001133)1.79196570
99Cone-rod dystrophy (HP:0000548)1.79162611
100Increased CSF lactate (HP:0002490)1.78978597
101Pachygyria (HP:0001302)1.77685686
102Abnormality of the nasal mucosa (HP:0000433)1.76737950
103Oculomotor apraxia (HP:0000657)1.76367919
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76303457
105Blue irides (HP:0000635)1.76076270
106Supernumerary spleens (HP:0009799)1.74565024
107Enlarged kidneys (HP:0000105)1.73379408
108Optic disc pallor (HP:0000543)1.71644703
109Inability to walk (HP:0002540)1.70991003
110Narrow forehead (HP:0000341)1.69081334
111Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68655536
112Absent eyebrow (HP:0002223)1.67371262
113Bronchitis (HP:0012387)1.67309178
114Abnormality of the lower motor neuron (HP:0002366)1.67004543
115Abnormal urine output (HP:0012590)1.66528607
116Severe muscular hypotonia (HP:0006829)1.65694898
117Multicystic kidney dysplasia (HP:0000003)1.64711655
118Oligodactyly (hands) (HP:0001180)1.63800500
119Lipid accumulation in hepatocytes (HP:0006561)1.63437596
120Abnormality of renal excretion (HP:0011036)1.63216418
121Aplasia/Hypoplasia of the fibula (HP:0006492)1.62987670
122Acute encephalopathy (HP:0006846)1.62966052
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.62915260
124Aganglionic megacolon (HP:0002251)1.62366104
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62148633
126Dialeptic seizures (HP:0011146)1.61928037
127Rib fusion (HP:0000902)1.61756363
128Hepatocellular necrosis (HP:0001404)1.61570989
129Polyphagia (HP:0002591)1.61426597
130Dandy-Walker malformation (HP:0001305)1.61232553
131Insomnia (HP:0100785)1.60337386
132Optic nerve hypoplasia (HP:0000609)1.59763579
133Retinal dysplasia (HP:0007973)1.59515462
134Abnormal mitochondria in muscle tissue (HP:0008316)1.58932496
135Tubulointerstitial fibrosis (HP:0005576)1.58506081
136Absent frontal sinuses (HP:0002688)1.58318335
137Progressive cerebellar ataxia (HP:0002073)1.57245962
138Progressive macrocephaly (HP:0004481)1.55707916
139Epiphyseal dysplasia (HP:0002656)1.55307479
140Hepatoblastoma (HP:0002884)1.55205367
141Flat cornea (HP:0007720)1.55112256
142Abnormality of the frontal sinuses (HP:0002687)1.54986188
143Visual hallucinations (HP:0002367)1.54342976
144Pancreatic cysts (HP:0001737)1.53210090
145Progressive inability to walk (HP:0002505)1.53144549
146Type II diabetes mellitus (HP:0005978)1.52746860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.10389732
2MAP4K23.43108264
3ADRBK23.11670408
4MAPK152.92187006
5PRKD32.88878073
6BMPR1B2.87702012
7CASK2.70032362
8ERBB32.62934138
9ZAK2.51190029
10AKT32.45739141
11TAOK32.44438153
12TRIM282.42416293
13NTRK32.41127548
14TLK12.26211356
15INSRR2.21273761
16PDK32.10286951
17PDK42.10286951
18TIE12.00952001
19BCR1.91674249
20SGK21.91613289
21MAP2K71.91363517
22DAPK21.85059484
23PRPF4B1.73628937
24NTRK21.69856560
25DYRK21.69513854
26SIK31.61176224
27STK38L1.58597018
28CDK191.57893063
29PHKG21.54231002
30PHKG11.54231002
31ACVR1B1.53921356
32MAP3K41.51609636
33OXSR11.51514360
34SGK2231.51204752
35SGK4941.51204752
36SGK31.49532736
37ICK1.47521741
38MARK11.42923929
39PINK11.39588236
40LMTK21.39004638
41PTK2B1.38347598
42WNK41.37155636
43MST41.35016183
44SIK21.34548247
45BCKDK1.31228988
46BMPR21.30763807
47KSR11.29835712
48PDK21.29180419
49MAPK131.28584297
50IRAK11.25609380
51DDR21.18230203
52PLK21.17070996
53STK381.15457515
54PLK41.14838715
55CSNK1G21.11743203
56ADRBK11.07773889
57RIPK11.07577267
58PAK31.07138117
59CDK31.05264528
60TNIK1.04553360
61TGFBR11.04432568
62EPHA41.04414197
63CAMK1G1.04026703
64NME11.03089887
65CSNK1G31.02354812
66MINK11.01496272
67CSNK1A1L0.99010123
68MAP3K120.96440772
69EPHB20.95890773
70SIK10.95413827
71CSNK1G10.92290476
72TYRO30.91816149
73TXK0.90248415
74NEK60.89248620
75PRKCG0.87814676
76CAMKK10.87379567
77CCNB10.87223198
78MUSK0.86905738
79STK240.85749442
80STK160.85541888
81WNK10.84176270
82MAP2K40.83280413
83MAP2K20.83180153
84IRAK20.82248066
85EPHB10.81281729
86DYRK1A0.80803427
87RPS6KA20.78938103
88FGFR20.75824570
89PRKCE0.74995634
90LATS10.74783167
91FGFR40.74144716
92GRK10.71769182
93PRKCI0.71441685
94PRKCH0.70441267
95STK390.69849147
96CDK50.69459927
97PNCK0.68677576
98FER0.67448545
99CAMK2A0.65810857
100EPHA30.64483401
101PRKCQ0.63567084
102CDC42BPA0.62169531
103TGFBR20.62030106
104PRKCZ0.61135127
105DYRK1B0.60871524
106VRK20.59275002
107FGFR30.57910828
108SGK10.57666153
109RPS6KA50.56721650
110HIPK20.56277651
111CAMK40.55545244
112STK30.55071267
113NUAK10.54932428
114CSNK1A10.54664127
115PIM20.53491329
116YES10.52946820
117CAMK10.51915702
118VRK10.51201794
119TNK20.51009781
120MAPKAPK30.49890519
121MARK20.49493792
122BRAF0.48946433
123CAMK2G0.48816745
124IKBKB0.48497909
125CAMKK20.47763941
126MARK30.47277415
127CDK80.46432822
128CAMK1D0.45770467
129ATR0.45583219
130PRKACA0.45266979
131PLK10.45124292
132UHMK10.45015528
133PDGFRB0.44923577
134STK110.44471528
135PRKAA10.44167600
136ERBB20.44120274
137PAK60.43487135
138CAMK2D0.42754100
139ROCK10.41866820
140MAP3K110.41381664
141CAMK2B0.41249901
142GRK70.40959863
143PDGFRA0.40196929
144ARAF0.40143181
145WNK30.39693822
146CDC70.38974929
147DYRK30.37755759
148PRKD20.37114876
149MAPK100.36908878
150MAP3K70.36775952
151GRK60.36435116
152BRSK20.33515446
153PKN10.33303139
154CHUK0.32553290
155MKNK20.31284575
156NEK20.29035367

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.58525370
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.07913735
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.05594185
4Phototransduction_Homo sapiens_hsa047442.87986306
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78374367
6Oxidative phosphorylation_Homo sapiens_hsa001902.55285645
7Taste transduction_Homo sapiens_hsa047422.33798216
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15630389
9Insulin secretion_Homo sapiens_hsa049112.13583566
10Nicotine addiction_Homo sapiens_hsa050332.09710957
11Huntingtons disease_Homo sapiens_hsa050162.02172710
12Selenocompound metabolism_Homo sapiens_hsa004502.01487696
13Linoleic acid metabolism_Homo sapiens_hsa005912.00352879
14Morphine addiction_Homo sapiens_hsa050321.98755924
15Circadian entrainment_Homo sapiens_hsa047131.93468466
16Parkinsons disease_Homo sapiens_hsa050121.91209353
17GABAergic synapse_Homo sapiens_hsa047271.88584262
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87591021
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84952151
20Synaptic vesicle cycle_Homo sapiens_hsa047211.84368828
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82390437
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78849946
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77276381
24Protein export_Homo sapiens_hsa030601.70964732
25Chemical carcinogenesis_Homo sapiens_hsa052041.69255113
26RNA polymerase_Homo sapiens_hsa030201.69159658
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68917652
28Fanconi anemia pathway_Homo sapiens_hsa034601.66619246
29Basal transcription factors_Homo sapiens_hsa030221.66147969
30Glutamatergic synapse_Homo sapiens_hsa047241.63407784
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61278550
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58783286
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51096527
34Homologous recombination_Homo sapiens_hsa034401.48638855
35Dorso-ventral axis formation_Homo sapiens_hsa043201.48328025
36Sulfur relay system_Homo sapiens_hsa041221.43107784
37Amphetamine addiction_Homo sapiens_hsa050311.41555295
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41354183
39Salivary secretion_Homo sapiens_hsa049701.36133155
40Nitrogen metabolism_Homo sapiens_hsa009101.32992974
41Gastric acid secretion_Homo sapiens_hsa049711.29155086
42Bile secretion_Homo sapiens_hsa049761.23961261
43Regulation of autophagy_Homo sapiens_hsa041401.21231149
44cAMP signaling pathway_Homo sapiens_hsa040241.20005327
45Cardiac muscle contraction_Homo sapiens_hsa042601.17952312
46Ether lipid metabolism_Homo sapiens_hsa005651.17801515
47ABC transporters_Homo sapiens_hsa020101.17089475
48Cocaine addiction_Homo sapiens_hsa050301.16923638
49Renin secretion_Homo sapiens_hsa049241.16497803
50Fatty acid biosynthesis_Homo sapiens_hsa000611.15259286
51Alzheimers disease_Homo sapiens_hsa050101.14671670
52Cholinergic synapse_Homo sapiens_hsa047251.14317664
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13549138
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11519608
55Dopaminergic synapse_Homo sapiens_hsa047281.11016356
56Caffeine metabolism_Homo sapiens_hsa002321.10949011
57Ovarian steroidogenesis_Homo sapiens_hsa049131.09659716
58Calcium signaling pathway_Homo sapiens_hsa040201.09656051
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04697863
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00232560
61Serotonergic synapse_Homo sapiens_hsa047261.00031761
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.99793685
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98350268
64RNA degradation_Homo sapiens_hsa030180.98050739
65Glucagon signaling pathway_Homo sapiens_hsa049220.96413901
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94171796
67Basal cell carcinoma_Homo sapiens_hsa052170.90999890
68Thyroid hormone synthesis_Homo sapiens_hsa049180.89535365
69Melanogenesis_Homo sapiens_hsa049160.89487114
70Type II diabetes mellitus_Homo sapiens_hsa049300.89467990
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88053384
72Long-term potentiation_Homo sapiens_hsa047200.87961504
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.86668949
74Axon guidance_Homo sapiens_hsa043600.86174664
75Histidine metabolism_Homo sapiens_hsa003400.84504844
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83787289
77Metabolic pathways_Homo sapiens_hsa011000.83389439
78Arachidonic acid metabolism_Homo sapiens_hsa005900.82688183
79Tyrosine metabolism_Homo sapiens_hsa003500.81025447
80Phenylalanine metabolism_Homo sapiens_hsa003600.79821917
81Protein digestion and absorption_Homo sapiens_hsa049740.79657029
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79447849
83Purine metabolism_Homo sapiens_hsa002300.78680288
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77888878
85Collecting duct acid secretion_Homo sapiens_hsa049660.76588752
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76289764
87Pancreatic secretion_Homo sapiens_hsa049720.74775956
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74138090
89Steroid biosynthesis_Homo sapiens_hsa001000.73725415
90Dilated cardiomyopathy_Homo sapiens_hsa054140.73697985
91PPAR signaling pathway_Homo sapiens_hsa033200.73380352
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.72347725
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71690339
94Pyrimidine metabolism_Homo sapiens_hsa002400.71328797
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69862630
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.69561289
97Glutathione metabolism_Homo sapiens_hsa004800.69412655
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69410871
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.69371868
100Proteasome_Homo sapiens_hsa030500.69193799
101Estrogen signaling pathway_Homo sapiens_hsa049150.68502812
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66380238
103Notch signaling pathway_Homo sapiens_hsa043300.64268311
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.63606340
105Oxytocin signaling pathway_Homo sapiens_hsa049210.63075304
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60807416
107GnRH signaling pathway_Homo sapiens_hsa049120.60219990
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59946109
109ECM-receptor interaction_Homo sapiens_hsa045120.59795231
110Hedgehog signaling pathway_Homo sapiens_hsa043400.57932081
111Propanoate metabolism_Homo sapiens_hsa006400.56862770
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56676951
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55593318
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55303660
115Glycerolipid metabolism_Homo sapiens_hsa005610.54606740
116Fatty acid degradation_Homo sapiens_hsa000710.54596751
117Arginine and proline metabolism_Homo sapiens_hsa003300.54588435
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54580211
119Base excision repair_Homo sapiens_hsa034100.53869768
120One carbon pool by folate_Homo sapiens_hsa006700.53616304
121Complement and coagulation cascades_Homo sapiens_hsa046100.53377269
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53085462
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52023219
124Inositol phosphate metabolism_Homo sapiens_hsa005620.51801881
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50364006
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49402408
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49314020
128Tryptophan metabolism_Homo sapiens_hsa003800.48885458
129Vibrio cholerae infection_Homo sapiens_hsa051100.48868557
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48186430
131Wnt signaling pathway_Homo sapiens_hsa043100.48089049
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47945888
133Retinol metabolism_Homo sapiens_hsa008300.47438009
134Fatty acid metabolism_Homo sapiens_hsa012120.46181020
135Insulin resistance_Homo sapiens_hsa049310.46146921
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45632693
137Lysine degradation_Homo sapiens_hsa003100.45615211
138Ras signaling pathway_Homo sapiens_hsa040140.45071218
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44522456
140Circadian rhythm_Homo sapiens_hsa047100.42483846
141Peroxisome_Homo sapiens_hsa041460.41128780
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41091663
143Starch and sucrose metabolism_Homo sapiens_hsa005000.41053276
144Butanoate metabolism_Homo sapiens_hsa006500.40221386
145Type I diabetes mellitus_Homo sapiens_hsa049400.40063755
146beta-Alanine metabolism_Homo sapiens_hsa004100.40027752
147Sphingolipid metabolism_Homo sapiens_hsa006000.39229468
148ErbB signaling pathway_Homo sapiens_hsa040120.37764191
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37377603
150Pyruvate metabolism_Homo sapiens_hsa006200.36888462
151Rap1 signaling pathway_Homo sapiens_hsa040150.36170953
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.35904668
153Nucleotide excision repair_Homo sapiens_hsa034200.32453301
154Ribosome_Homo sapiens_hsa030100.30038223
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29240062
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.27712621
157Primary immunodeficiency_Homo sapiens_hsa053400.27535211

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