CCDC158

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.46891243
2multicellular organism reproduction (GO:0032504)9.42742453
3male meiosis (GO:0007140)9.18640422
4acrosome assembly (GO:0001675)9.05898522
5epithelial cilium movement (GO:0003351)8.94690342
6binding of sperm to zona pellucida (GO:0007339)8.80903619
7motile cilium assembly (GO:0044458)8.63311179
8plasma membrane fusion (GO:0045026)8.50598679
9cell-cell recognition (GO:0009988)8.44039032
10acrosome reaction (GO:0007340)8.41818374
11cell wall macromolecule metabolic process (GO:0044036)8.34012605
12cell wall macromolecule catabolic process (GO:0016998)8.34012605
13synaptonemal complex organization (GO:0070193)8.29407934
14cilium movement (GO:0003341)8.12950530
15synaptonemal complex assembly (GO:0007130)8.09234811
16spermatid development (GO:0007286)8.08169529
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.97475957
18reproduction (GO:0000003)7.60591249
19DNA methylation involved in gamete generation (GO:0043046)7.43068704
20regulation of cilium movement (GO:0003352)7.00399144
21male meiosis I (GO:0007141)6.63811885
22single fertilization (GO:0007338)6.42573697
23chromosome organization involved in meiosis (GO:0070192)6.02939145
24meiotic nuclear division (GO:0007126)5.79238197
25fertilization (GO:0009566)5.73659347
26sperm capacitation (GO:0048240)5.60811065
27meiosis I (GO:0007127)5.47681237
28spermatogenesis (GO:0007283)5.43574827
29male gamete generation (GO:0048232)5.42193462
30microtubule depolymerization (GO:0007019)5.33308222
31meiotic cell cycle (GO:0051321)5.30786718
32negative regulation of inclusion body assembly (GO:0090084)5.16074783
33gamete generation (GO:0007276)5.05939153
34response to pheromone (GO:0019236)4.98651209
35germ cell development (GO:0007281)4.95410957
36ventricular system development (GO:0021591)4.86436097
37behavioral response to nicotine (GO:0035095)4.82452874
38cellular process involved in reproduction in multicellular organism (GO:0022412)4.80022548
39regulation of meiosis I (GO:0060631)4.58169558
40monoubiquitinated protein deubiquitination (GO:0035520)4.55242031
41gene silencing by RNA (GO:0031047)4.36241582
42cellular ketone body metabolic process (GO:0046950)4.31502590
43organic cation transport (GO:0015695)4.20683865
44regulation of inclusion body assembly (GO:0090083)4.17360132
45meiotic cell cycle process (GO:1903046)4.14617152
46microtubule severing (GO:0051013)4.07790800
47L-fucose catabolic process (GO:0042355)4.04491972
48fucose catabolic process (GO:0019317)4.04491972
49L-fucose metabolic process (GO:0042354)4.04491972
50nuclear pore complex assembly (GO:0051292)4.02883753
51seminiferous tubule development (GO:0072520)3.97300301
52multicellular organismal reproductive process (GO:0048609)3.95440361
53regulation of centriole replication (GO:0046599)3.91105275
54regulation of microtubule-based movement (GO:0060632)3.89383135
55intraciliary transport (GO:0042073)3.87768566
56cell recognition (GO:0008037)3.85359457
57ketone body metabolic process (GO:1902224)3.83274853
58synapsis (GO:0007129)3.81403546
59protein localization to cilium (GO:0061512)3.78905885
60mitotic sister chromatid cohesion (GO:0007064)3.67784887
61detection of light stimulus involved in visual perception (GO:0050908)3.59919482
62detection of light stimulus involved in sensory perception (GO:0050962)3.59919482
63protein polyglutamylation (GO:0018095)3.56432469
64calcium ion-dependent exocytosis (GO:0017156)3.53194328
65DNA packaging (GO:0006323)3.52924407
66axoneme assembly (GO:0035082)3.50383185
67chromosome condensation (GO:0030261)3.49696084
68centriole replication (GO:0007099)3.48231310
69photoreceptor cell maintenance (GO:0045494)3.47118621
70establishment of protein localization to Golgi (GO:0072600)3.44576942
71centriole assembly (GO:0098534)3.44483567
72genitalia morphogenesis (GO:0035112)3.44324845
73indolalkylamine metabolic process (GO:0006586)3.44052821
74left/right pattern formation (GO:0060972)3.42094614
75indole-containing compound catabolic process (GO:0042436)3.40496224
76indolalkylamine catabolic process (GO:0046218)3.40496224
77tryptophan catabolic process (GO:0006569)3.40496224
78primary amino compound metabolic process (GO:1901160)3.39945142
79nuclear pore organization (GO:0006999)3.37996183
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32464761
81sister chromatid cohesion (GO:0007062)3.30402399
82histone exchange (GO:0043486)3.29928025
83spermatid nucleus differentiation (GO:0007289)3.28155688
84regulation of spindle checkpoint (GO:0090231)3.26150049
85DNA alkylation (GO:0006305)3.25381351
86DNA methylation (GO:0006306)3.25381351
87protein targeting to Golgi (GO:0000042)3.22747819
88chaperone-mediated protein complex assembly (GO:0051131)3.22714457
89cilium organization (GO:0044782)3.20708156
90kynurenine metabolic process (GO:0070189)3.20288373
91neuronal action potential (GO:0019228)3.18411266
92retinal cone cell development (GO:0046549)3.16067096
93RNA destabilization (GO:0050779)3.11419732
94multicellular organismal development (GO:0007275)3.10774146
95platelet dense granule organization (GO:0060155)3.10481524
96amine catabolic process (GO:0009310)3.08558684
97cellular biogenic amine catabolic process (GO:0042402)3.08558684
98pore complex assembly (GO:0046931)3.08441557
99serotonin metabolic process (GO:0042428)3.08198390
100regulation of histone H3-K9 methylation (GO:0051570)3.08138353
101meiotic chromosome segregation (GO:0045132)3.07900984
102microtubule-based movement (GO:0007018)3.06480712
103tryptophan metabolic process (GO:0006568)3.05165359
104gene silencing (GO:0016458)3.04917755
105regulation of hexokinase activity (GO:1903299)3.04379636
106regulation of glucokinase activity (GO:0033131)3.04379636
107gamma-aminobutyric acid transport (GO:0015812)3.04229478
108protein localization to chromosome, centromeric region (GO:0071459)3.04207653
109cilium assembly (GO:0042384)3.03628934
110negative regulation of organelle assembly (GO:1902116)3.03225102
111nonmotile primary cilium assembly (GO:0035058)3.01303225
112indole-containing compound metabolic process (GO:0042430)2.98932897
113nucleoside diphosphate phosphorylation (GO:0006165)2.97884330
114cilium morphogenesis (GO:0060271)2.92568427
115nucleus organization (GO:0006997)2.91886861
116glycerophospholipid catabolic process (GO:0046475)2.89920716
117translesion synthesis (GO:0019985)2.89183451
118protein refolding (GO:0042026)2.87433032
119retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85013085
120negative regulation of telomere maintenance (GO:0032205)2.84593055
121glycerol ether metabolic process (GO:0006662)2.82822896
122microtubule polymerization or depolymerization (GO:0031109)2.79936320
123reciprocal meiotic recombination (GO:0007131)2.79189342
124reciprocal DNA recombination (GO:0035825)2.79189342
125preassembly of GPI anchor in ER membrane (GO:0016254)2.76942999
126protein localization to Golgi apparatus (GO:0034067)2.76934436
127cornea development in camera-type eye (GO:0061303)2.75857466
128phosphatidylethanolamine metabolic process (GO:0046337)2.74653016
129cellular component assembly involved in morphogenesis (GO:0010927)2.74501629
130behavioral response to ethanol (GO:0048149)2.73472714
131GTP biosynthetic process (GO:0006183)2.73115366
132phosphatidylethanolamine biosynthetic process (GO:0006646)2.71993877
133regulation of action potential (GO:0098900)2.71049267
134DNA deamination (GO:0045006)2.69672555
135protein K11-linked deubiquitination (GO:0035871)2.68887124
136single strand break repair (GO:0000012)2.67730533
137cAMP catabolic process (GO:0006198)2.66075296
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.65686910
139pyrimidine nucleobase catabolic process (GO:0006208)2.64930742
140mannosylation (GO:0097502)2.63804039
141water-soluble vitamin biosynthetic process (GO:0042364)2.63670742
142nucleobase catabolic process (GO:0046113)2.60173929
143ether metabolic process (GO:0018904)2.59134518
144lactate metabolic process (GO:0006089)2.58253240
145chromosome organization (GO:0051276)2.57543525
146photoreceptor cell development (GO:0042461)2.56672241
147respiratory chain complex IV assembly (GO:0008535)2.54807729
148spinal cord motor neuron differentiation (GO:0021522)2.54139449
149dopamine transport (GO:0015872)2.53035387
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51972381
151cyclic nucleotide catabolic process (GO:0009214)2.51834667
152regulation of telomere maintenance (GO:0032204)2.48666119
153S-adenosylmethionine metabolic process (GO:0046500)2.48058974
154sulfation (GO:0051923)2.47794138
155reflex (GO:0060004)2.47246276
156synaptic transmission, cholinergic (GO:0007271)2.46266847
157protein complex biogenesis (GO:0070271)2.46260291
158cilium or flagellum-dependent cell motility (GO:0001539)13.2016298
159fusion of sperm to egg plasma membrane (GO:0007342)11.1726862
160piRNA metabolic process (GO:0034587)10.9265668
161axonemal dynein complex assembly (GO:0070286)10.3036901
162sperm motility (GO:0030317)10.0584104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.40371559
2EZH2_22144423_ChIP-Seq_EOC_Human3.63034018
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.34129265
4GBX2_23144817_ChIP-Seq_PC3_Human2.83226204
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45655410
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44577935
7IGF1R_20145208_ChIP-Seq_DFB_Human2.43523599
8* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.43272909
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.38183143
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36175060
11E2F7_22180533_ChIP-Seq_HELA_Human2.26194721
12TAF15_26573619_Chip-Seq_HEK293_Human2.25856649
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19140109
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18236525
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.14384668
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13232956
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11897089
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.08215290
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07742793
20P300_19829295_ChIP-Seq_ESCs_Human2.07311328
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0622136
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.95513435
23ER_23166858_ChIP-Seq_MCF-7_Human1.94528667
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82693984
25EWS_26573619_Chip-Seq_HEK293_Human1.76811263
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75885737
27ZNF274_21170338_ChIP-Seq_K562_Hela1.69978438
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69097552
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64637730
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63084693
31STAT3_23295773_ChIP-Seq_U87_Human1.62913899
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62091704
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60142291
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60065282
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59527532
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.58991429
37* AR_25329375_ChIP-Seq_VCAP_Human1.58297639
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58295039
39STAT1_17558387_ChIP-Seq_HELA_Human1.57644022
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56732560
41BCAT_22108803_ChIP-Seq_LS180_Human1.55235475
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.52693681
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52316693
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50695748
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50110822
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48806457
47TCF4_23295773_ChIP-Seq_U87_Human1.48518363
48VDR_22108803_ChIP-Seq_LS180_Human1.47696462
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46371646
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43081830
51TP53_22573176_ChIP-Seq_HFKS_Human1.42479668
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.41765454
53SOX2_19829295_ChIP-Seq_ESCs_Human1.41455630
54NANOG_19829295_ChIP-Seq_ESCs_Human1.41455630
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.41356474
56* TAL1_26923725_Chip-Seq_HPCs_Mouse1.41230109
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.39823344
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39600999
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39381585
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38853500
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.38853500
62* REST_21632747_ChIP-Seq_MESCs_Mouse1.37453696
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36649553
64RUNX1_26923725_Chip-Seq_HPCs_Mouse1.35709911
65IRF1_19129219_ChIP-ChIP_H3396_Human1.35415486
66* RUNX2_22187159_ChIP-Seq_PCA_Human1.34916603
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34180713
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33603015
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.33373961
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.31896859
71FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31321230
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29842795
73RNF2_27304074_Chip-Seq_NSC_Mouse1.29615348
74WDR5_24793694_ChIP-Seq_LNCAP_Human1.28527086
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27945772
76TCF4_22108803_ChIP-Seq_LS180_Human1.26494009
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.25034305
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24291619
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24193821
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23413825
81NCOR_22424771_ChIP-Seq_293T_Human1.22403514
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.21623166
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21538774
84SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21080558
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.19836583
86SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19600529
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.19454114
88GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.18411130
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.17320791
90KDM2B_26808549_Chip-Seq_REH_Human1.16588092
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16235561
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16049125
93CBP_20019798_ChIP-Seq_JUKART_Human1.16049125
94* HOXB7_26014856_ChIP-Seq_BT474_Human1.15465517
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.15179201
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.14207515
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13854453
98FUS_26573619_Chip-Seq_HEK293_Human1.13142507
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.12965016
100AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12454229
101AR_20517297_ChIP-Seq_VCAP_Human1.12411613
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11789560
103ERA_21632823_ChIP-Seq_H3396_Human1.11724762
104MYC_18940864_ChIP-ChIP_HL60_Human1.10970049
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10404921
106* MYC_19829295_ChIP-Seq_ESCs_Human1.10121591
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09903089
108* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09849505
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07942225
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06895231
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.06663483
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05870052
113FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05834657
114P53_22387025_ChIP-Seq_ESCs_Mouse1.04572982
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04395483
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04340058
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.03840906
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02885707
119CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02368102
120* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02359385
121* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02359385
122NANOG_20526341_ChIP-Seq_ESCs_Human1.02128412
123CDX2_22108803_ChIP-Seq_LS180_Human1.01698693
124ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01627035
125ETV1_20927104_ChIP-Seq_GIST48_Human1.01229974
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01067214
127* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00330971
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.00201989
129P300_18555785_Chip-Seq_ESCs_Mouse0.99408906
130AR_21572438_ChIP-Seq_LNCaP_Human0.99272387
131FOXH1_21741376_ChIP-Seq_EPCs_Human0.99124473
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99014969
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98567229
134HTT_18923047_ChIP-ChIP_STHdh_Human0.98459563
135AR_21909140_ChIP-Seq_LNCAP_Human0.98293679
136* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98229894
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.97965451
138SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97511528
139GF1_26923725_Chip-Seq_HPCs_Mouse0.96946282
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96845849
141OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96428828
142ERG_20517297_ChIP-Seq_VCAP_Human0.95535652
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95218049
144LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94604661
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94565982
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.93845585
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93305234
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92963212
149SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91400400
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91171919
151ZFX_18555785_Chip-Seq_ESCs_Mouse0.90830132
152CTCF_18555785_Chip-Seq_ESCs_Mouse0.87845449
153PU1_27457419_Chip-Seq_LIVER_Mouse0.86943838
154KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86653925
155NFYB_21822215_ChIP-Seq_K562_Human0.86262022
156E2F1_18555785_Chip-Seq_ESCs_Mouse0.86178260
157SOX2_18555785_Chip-Seq_ESCs_Mouse0.85418694
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.85037460
159NMYC_18555785_Chip-Seq_ESCs_Mouse0.82935567
160ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82816897
161* P53_21459846_ChIP-Seq_SAOS-2_Human0.82069018
162TBL1_22424771_ChIP-Seq_293T_Human0.81236918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.23624773
2MP0003698_abnormal_male_reproductive5.48979359
3MP0001929_abnormal_gametogenesis5.47209376
4MP0002210_abnormal_sex_determination4.17739630
5MP0002653_abnormal_ependyma_morphology3.58362097
6MP0001145_abnormal_male_reproductive3.44553822
7MP0003195_calcinosis3.39459341
8MP0008057_abnormal_DNA_replication3.27791099
9MP0000653_abnormal_sex_gland3.13854927
10MP0002161_abnormal_fertility/fecundity3.13364278
11MP0010094_abnormal_chromosome_stability2.82567177
12MP0008058_abnormal_DNA_repair2.63830509
13MP0002837_dystrophic_cardiac_calcinosis2.59430905
14MP0001968_abnormal_touch/_nociception2.52893725
15MP0002160_abnormal_reproductive_system2.01450830
16MP0005410_abnormal_fertilization12.2787791
17MP0003111_abnormal_nucleus_morphology1.99617869
18MP0005645_abnormal_hypothalamus_physiol1.98438165
19MP0002736_abnormal_nociception_after1.96660863
20MP0006072_abnormal_retinal_apoptosis1.95862036
21MP0008995_early_reproductive_senescence1.90950432
22MP0008007_abnormal_cellular_replicative1.87242078
23MP0009745_abnormal_behavioral_response1.87122900
24MP0002876_abnormal_thyroid_physiology1.79600277
25MP0001486_abnormal_startle_reflex1.78185402
26MP0002272_abnormal_nervous_system1.77731306
27MP0005623_abnormal_meninges_morphology1.76663313
28MP0001501_abnormal_sleep_pattern1.74188088
29MP0003077_abnormal_cell_cycle1.71564670
30MP0003786_premature_aging1.61962445
31MP0003693_abnormal_embryo_hatching1.61921142
32MP0001485_abnormal_pinna_reflex1.59645473
33MP0003646_muscle_fatigue1.55166396
34MP0003880_abnormal_central_pattern1.54137161
35MP0008875_abnormal_xenobiotic_pharmacok1.50359120
36MP0005379_endocrine/exocrine_gland_phen1.49244842
37MP0004885_abnormal_endolymph1.46881948
38MP0002572_abnormal_emotion/affect_behav1.42686076
39MP0008872_abnormal_physiological_respon1.42214147
40MP0002557_abnormal_social/conspecific_i1.41103679
41MP0002735_abnormal_chemical_nociception1.40758704
42MP0004043_abnormal_pH_regulation1.40206689
43MP0004142_abnormal_muscle_tone1.39335705
44MP0010386_abnormal_urinary_bladder1.39318080
45MP0005670_abnormal_white_adipose1.37039282
46MP0005084_abnormal_gallbladder_morpholo1.36227219
47MP0002064_seizures1.30558874
48MP0004133_heterotaxia1.29555674
49MP0004147_increased_porphyrin_level1.29268516
50MP0004742_abnormal_vestibular_system1.27526884
51MP0002282_abnormal_trachea_morphology1.27324137
52MP0002733_abnormal_thermal_nociception1.27044787
53MP0005389_reproductive_system_phenotype1.26071600
54MP0004808_abnormal_hematopoietic_stem1.22730438
55MP0000631_abnormal_neuroendocrine_gland1.21573089
56MP0006276_abnormal_autonomic_nervous1.20126159
57MP0005647_abnormal_sex_gland1.19547920
58MP0001970_abnormal_pain_threshold1.18873012
59MP0001119_abnormal_female_reproductive1.17207607
60MP0002102_abnormal_ear_morphology1.16612519
61MP0002067_abnormal_sensory_capabilities1.15149416
62MP0005167_abnormal_blood-brain_barrier1.13937555
63MP0001545_abnormal_hematopoietic_system1.11490329
64MP0005397_hematopoietic_system_phenotyp1.11490329
65MP0002138_abnormal_hepatobiliary_system1.11391880
66MP0002229_neurodegeneration1.10029413
67MP0001984_abnormal_olfaction1.09236969
68MP0001529_abnormal_vocalization1.07462239
69MP0000372_irregular_coat_pigmentation1.06731683
70MP0005085_abnormal_gallbladder_physiolo1.06636881
71MP0001905_abnormal_dopamine_level1.04413131
72MP0004924_abnormal_behavior1.04403498
73MP0005386_behavior/neurological_phenoty1.04403498
74MP0003635_abnormal_synaptic_transmissio1.03852953
75MP0008789_abnormal_olfactory_epithelium1.03531284
76MP0002638_abnormal_pupillary_reflex1.03490646
77MP0002163_abnormal_gland_morphology1.01875690
78MP0008775_abnormal_heart_ventricle1.01612420
79MP0002063_abnormal_learning/memory/cond0.99273500
80MP0001963_abnormal_hearing_physiology0.98555607
81MP0003699_abnormal_female_reproductive0.98453262
82MP0004957_abnormal_blastocyst_morpholog0.97100551
83MP0002909_abnormal_adrenal_gland0.95082295
84MP0010329_abnormal_lipoprotein_level0.93846269
85MP0004215_abnormal_myocardial_fiber0.92052474
86MP0002254_reproductive_system_inflammat0.91627037
87MP0000230_abnormal_systemic_arterial0.90267178
88MP0005365_abnormal_bile_salt0.89094371
89MP0003718_maternal_effect0.88371431
90MP0005332_abnormal_amino_acid0.86816395
91MP0002184_abnormal_innervation0.85580766
92MP0009697_abnormal_copulation0.85543386
93MP0000026_abnormal_inner_ear0.85442668
94MP0004085_abnormal_heartbeat0.84145851
95MP0005195_abnormal_posterior_eye0.83215917
96MP0003252_abnormal_bile_duct0.82705567
97MP0002734_abnormal_mechanical_nocicepti0.82337720
98MP0003137_abnormal_impulse_conducting0.81254095
99MP0002752_abnormal_somatic_nervous0.81117756
100MP0001293_anophthalmia0.80810222
101MP0003283_abnormal_digestive_organ0.80625501
102MP0008932_abnormal_embryonic_tissue0.80518294
103MP0001730_embryonic_growth_arrest0.78809043
104MP0010307_abnormal_tumor_latency0.77640294
105MP0004233_abnormal_muscle_weight0.74797338
106MP0000358_abnormal_cell_content/0.69740284
107MP0002234_abnormal_pharynx_morphology0.65594020
108MP0000313_abnormal_cell_death0.65502302
109MP0003878_abnormal_ear_physiology0.62848234
110MP0005377_hearing/vestibular/ear_phenot0.62848234
111MP0005380_embryogenesis_phenotype0.61309772
112MP0001672_abnormal_embryogenesis/_devel0.61309772
113MP0002928_abnormal_bile_duct0.61289663
114MP0000350_abnormal_cell_proliferation0.60992950
115MP0003950_abnormal_plasma_membrane0.58174341
116MP0001697_abnormal_embryo_size0.57490087
117MP0002084_abnormal_developmental_patter0.57251062
118MP0002085_abnormal_embryonic_tissue0.56621804
119MP0009046_muscle_twitch0.56387396
120MP0001765_abnormal_ion_homeostasis0.55551593
121MP0003115_abnormal_respiratory_system0.55380967
122MP0003787_abnormal_imprinting0.54456112
123MP0003890_abnormal_embryonic-extraembry0.54015365
124MP0001986_abnormal_taste_sensitivity0.52821019
125MP0001764_abnormal_homeostasis0.49102967
126MP0003984_embryonic_growth_retardation0.46856004
127MP0003943_abnormal_hepatobiliary_system0.46799848
128MP0003011_delayed_dark_adaptation0.46130967
129MP0002080_prenatal_lethality0.45051467
130MP0003315_abnormal_perineum_morphology0.44399770
131MP0002088_abnormal_embryonic_growth/wei0.43849063
132MP0003121_genomic_imprinting0.43139969
133MP0001324_abnormal_eye_pigmentation0.43116530
134MP0002019_abnormal_tumor_incidence0.43028733
135MP0009278_abnormal_bone_marrow0.42663357
136MP0003861_abnormal_nervous_system0.41575068
137MP0002132_abnormal_respiratory_system0.41343181
138MP0000569_abnormal_digit_pigmentation0.40511153
139MP0005391_vision/eye_phenotype0.39421181
140MP0004197_abnormal_fetal_growth/weight/0.37630061
141MP0005395_other_phenotype0.37265715
142MP0001919_abnormal_reproductive_system0.37068546
143MP0006036_abnormal_mitochondrial_physio0.36609361
144MP0005174_abnormal_tail_pigmentation0.36292151
145MP0002009_preneoplasia0.36223677
146MP0002092_abnormal_eye_morphology0.35799705
147MP0005646_abnormal_pituitary_gland0.34190732
148MP0004134_abnormal_chest_morphology0.34073883
149MP0000432_abnormal_head_morphology0.33502066
150MP0004264_abnormal_extraembryonic_tissu0.33416100
151MP0005551_abnormal_eye_electrophysiolog0.32357526
152MP0001915_intracranial_hemorrhage0.31950041
153MP0003936_abnormal_reproductive_system0.31444170
154MP0005266_abnormal_metabolism0.31054916
155MP0000427_abnormal_hair_cycle0.30475055
156MP0003942_abnormal_urinary_system0.30295441
157MP0005253_abnormal_eye_physiology0.30199927
158MP0009115_abnormal_fat_cell0.30168214
159MP0002938_white_spotting0.29866372
160MP0005636_abnormal_mineral_homeostasis0.29826053
161MP0002249_abnormal_larynx_morphology0.29789784
162MP0002971_abnormal_brown_adipose0.29780539
163MP0006292_abnormal_olfactory_placode0.29412147
164MP0005075_abnormal_melanosome_morpholog0.28622105
165MP0002114_abnormal_axial_skeleton0.27700491

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.36067519
2Abnormal respiratory motile cilium morphology (HP:0005938)8.35095061
3Abnormal respiratory epithelium morphology (HP:0012253)8.35095061
4Abnormal ciliary motility (HP:0012262)7.92143629
5Rhinitis (HP:0012384)7.71379027
6Chronic bronchitis (HP:0004469)6.86846801
7Infertility (HP:0000789)5.92031361
8Nasal polyposis (HP:0100582)5.83146641
9Abnormality of the nasal mucosa (HP:0000433)4.80429927
10Nephronophthisis (HP:0000090)4.67304033
11Bronchiectasis (HP:0002110)4.65135345
12Bronchitis (HP:0012387)4.17790986
13Abnormal spermatogenesis (HP:0008669)3.87378685
14Male infertility (HP:0003251)3.78160306
15Attenuation of retinal blood vessels (HP:0007843)3.76213529
16Abnormality of the renal medulla (HP:0100957)3.61238056
17Congenital stationary night blindness (HP:0007642)3.42471757
18Type II lissencephaly (HP:0007260)3.29557200
19Azoospermia (HP:0000027)3.18685308
20Molar tooth sign on MRI (HP:0002419)3.10579926
21Abnormality of midbrain morphology (HP:0002418)3.10579926
22Hyperventilation (HP:0002883)3.08353658
23Gonadotropin excess (HP:0000837)3.06644362
24Recurrent sinusitis (HP:0011108)3.05812415
25Tubulointerstitial nephritis (HP:0001970)3.05787853
26Abnormal rod and cone electroretinograms (HP:0008323)3.04241512
27Recurrent otitis media (HP:0000403)2.93593400
28Impulsivity (HP:0100710)2.88764101
29Bony spicule pigmentary retinopathy (HP:0007737)2.78203915
30Decreased central vision (HP:0007663)2.78113367
31Medial flaring of the eyebrow (HP:0010747)2.76932343
32Inability to walk (HP:0002540)2.74682453
33Pendular nystagmus (HP:0012043)2.72464866
34Abnormality of the lower motor neuron (HP:0002366)2.72193864
35Gaze-evoked nystagmus (HP:0000640)2.70263655
36Supernumerary spleens (HP:0009799)2.67661482
37Fibular hypoplasia (HP:0003038)2.67496864
38Abolished electroretinogram (ERG) (HP:0000550)2.55700053
39Tubular atrophy (HP:0000092)2.54276777
40Postaxial foot polydactyly (HP:0001830)2.52902120
41Progressive cerebellar ataxia (HP:0002073)2.47131604
42Severe visual impairment (HP:0001141)2.46450873
43Polyuria (HP:0000103)2.45420305
44Tubulointerstitial abnormality (HP:0001969)2.45339568
45Increased corneal curvature (HP:0100692)2.43709075
46Keratoconus (HP:0000563)2.43709075
47Pancreatic fibrosis (HP:0100732)2.41186587
48Abnormality of alanine metabolism (HP:0010916)2.39701393
49Hyperalaninemia (HP:0003348)2.39701393
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39701393
51Abnormality of macular pigmentation (HP:0008002)2.39419496
52Recurrent bronchitis (HP:0002837)2.38420443
53Hypothermia (HP:0002045)2.35030100
54Febrile seizures (HP:0002373)2.33421236
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31919099
56Intestinal atresia (HP:0011100)2.30979750
57Progressive inability to walk (HP:0002505)2.30039938
58Congenital sensorineural hearing impairment (HP:0008527)2.27109893
59Large for gestational age (HP:0001520)2.23608770
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22580298
61Abnormality of the anterior horn cell (HP:0006802)2.21632914
62Degeneration of anterior horn cells (HP:0002398)2.21632914
63Congenital hepatic fibrosis (HP:0002612)2.21623410
64Renal cortical cysts (HP:0000803)2.20846015
65Lissencephaly (HP:0001339)2.18187917
66Amyotrophic lateral sclerosis (HP:0007354)2.13622418
67True hermaphroditism (HP:0010459)2.11168842
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10998715
69Optic nerve hypoplasia (HP:0000609)2.10328280
70Impaired proprioception (HP:0010831)2.10231242
71Genital tract atresia (HP:0001827)2.10129039
72Sclerocornea (HP:0000647)2.08174270
73Cerebellar dysplasia (HP:0007033)2.07613726
74Abnormal urine output (HP:0012590)2.07167836
75Hemiparesis (HP:0001269)2.07140984
76Abnormality of the renal cortex (HP:0011035)2.05015466
77Facial cleft (HP:0002006)2.03881888
78Cystic liver disease (HP:0006706)2.03320512
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.02444355
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01310899
81Fair hair (HP:0002286)2.00386284
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7328322
83Dynein arm defect of respiratory motile cilia (HP:0012255)11.2228139
84Absent/shortened dynein arms (HP:0200106)11.2228139
85Ketoacidosis (HP:0001993)1.99670482
86Polyphagia (HP:0002591)1.99591564
8711 pairs of ribs (HP:0000878)1.98731250
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.97371630
89Bile duct proliferation (HP:0001408)1.97187799
90Abnormal biliary tract physiology (HP:0012439)1.97187799
91Absent speech (HP:0001344)1.96520224
92Vaginal atresia (HP:0000148)1.96270890
93Protruding tongue (HP:0010808)1.95552809
94Oculomotor apraxia (HP:0000657)1.95264237
95Renal dysplasia (HP:0000110)1.95105271
96Stage 5 chronic kidney disease (HP:0003774)1.94310422
97Retinal dysplasia (HP:0007973)1.93896570
98Genetic anticipation (HP:0003743)1.93327804
99Optic disc pallor (HP:0000543)1.92329720
100Focal motor seizures (HP:0011153)1.92273226
101Ketosis (HP:0001946)1.89815891
102Abnormality of renal excretion (HP:0011036)1.88281363
103Anencephaly (HP:0002323)1.88172541
104Pachygyria (HP:0001302)1.87676936
105Pancreatic cysts (HP:0001737)1.87408846
106Dialeptic seizures (HP:0011146)1.86615977
107Agitation (HP:0000713)1.84530583
108Tubulointerstitial fibrosis (HP:0005576)1.83626421
109Short ribs (HP:0000773)1.83420396
110Widely spaced teeth (HP:0000687)1.82945347
111Median cleft lip (HP:0000161)1.82358177
112Chronic sinusitis (HP:0011109)1.81490935
113Methylmalonic acidemia (HP:0002912)1.80863553
114Oligodactyly (hands) (HP:0001180)1.79506230
115Acute necrotizing encephalopathy (HP:0006965)1.78284014
116Polydipsia (HP:0001959)1.77446665
117Abnormal drinking behavior (HP:0030082)1.77446665
118Broad-based gait (HP:0002136)1.77362942
119Congenital primary aphakia (HP:0007707)1.77351595
120Postaxial hand polydactyly (HP:0001162)1.76453849
121Sloping forehead (HP:0000340)1.75779449
122Aplasia/Hypoplasia of the fibula (HP:0006492)1.75122285
123Increased CSF lactate (HP:0002490)1.74823236
124J-shaped sella turcica (HP:0002680)1.72972967
125Gait imbalance (HP:0002141)1.72953810
126Abnormality of urine glucose concentration (HP:0011016)1.72008973
127Glycosuria (HP:0003076)1.72008973
128Upper motor neuron abnormality (HP:0002127)1.71872919
129Methylmalonic aciduria (HP:0012120)1.71831613
130Focal seizures (HP:0007359)1.71707148
131Microglossia (HP:0000171)1.71442134
132Nephroblastoma (Wilms tumor) (HP:0002667)1.71351685
133Retinitis pigmentosa (HP:0000510)1.69135037
134Abnormality of the labia minora (HP:0012880)1.68266318
135Type II diabetes mellitus (HP:0005978)1.67128560
136Decreased circulating renin level (HP:0003351)1.66089875
137Progressive macrocephaly (HP:0004481)1.65311011
138Heterotopia (HP:0002282)1.64575828
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64007063
140Absent epiphyses (HP:0010577)1.64007063
141Occipital encephalocele (HP:0002085)1.63100893
142Nephrogenic diabetes insipidus (HP:0009806)1.62266181
143Embryonal renal neoplasm (HP:0011794)1.59538432
144Short thorax (HP:0010306)1.55777674
145Absent frontal sinuses (HP:0002688)1.55250670
146Poor coordination (HP:0002370)1.54198957
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53460394
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.51951642
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51484054
150Ectopic kidney (HP:0000086)1.49662016
151Deformed sella turcica (HP:0002681)1.49178273
152Selective tooth agenesis (HP:0001592)1.48135639
153Breast carcinoma (HP:0003002)1.48110079
154Meckel diverticulum (HP:0002245)1.46143916
155Chromsome breakage (HP:0040012)1.45903139
156Abnormality of chromosome stability (HP:0003220)1.41507219
157Abnormality of the preputium (HP:0100587)1.39111421
158Abnormality of the ileum (HP:0001549)1.38564173
159Chronic hepatic failure (HP:0100626)1.38493666
160Male pseudohermaphroditism (HP:0000037)1.36570682
161Abnormality of the dental root (HP:0006486)1.36094928
162Taurodontia (HP:0000679)1.36094928
163Abnormality of permanent molar morphology (HP:0011071)1.36094928
164Cholecystitis (HP:0001082)1.34402844
165Abnormal gallbladder physiology (HP:0012438)1.34402844
166Abnormality of the carotid arteries (HP:0005344)1.32637890
167Abnormality of ocular smooth pursuit (HP:0000617)1.32051501
168Abnormality of molar morphology (HP:0011070)1.31937229
169Abnormality of molar (HP:0011077)1.31937229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.45177973
2PDK38.45177973
3FRK5.41614207
4PDK25.28673665
5TESK13.57401914
6MAP4K23.37249663
7ADRBK23.33721015
8PRKD33.30471117
9PNCK2.55079971
10ICK2.54562870
11NEK22.49090321
12NUAK12.38222853
13INSRR2.27663948
14GRK12.27487784
15CASK2.15083989
16CDC72.15082021
17TLK12.11758742
18PTK2B2.03222354
19TAOK31.95752630
20TTK1.85280418
21OXSR11.82322337
22WEE11.80376062
23PLK21.76865908
24WNK41.75756283
25TRIM281.75187209
26MAPK131.65814995
27PLK41.59950661
28STK391.55979164
29STK31.47247497
30DAPK21.41473065
31STK38L1.34468388
32CHEK21.33078927
33CCNB11.31053838
34STK381.28201919
35ATR1.16968540
36TNIK1.12446498
37DYRK31.11987560
38PHKG11.11327403
39PHKG21.11327403
40PRKCE1.08424297
41MARK11.06131842
42PLK11.03214905
43PRKCG1.02325975
44ADRBK11.00748033
45PASK0.98116643
46BRSK20.97712392
47CSNK1G20.97710787
48PAK30.97666780
49BCR0.96485990
50MAPK150.94994514
51TXK0.91015855
52CSNK1G10.88635740
53CHEK10.87311421
54TIE10.86979746
55CDK120.85532856
56CSNK1G30.85445707
57ACVR1B0.85407488
58MUSK0.83597990
59DYRK1B0.82900819
60BUB10.79884730
61ATM0.74906086
62TYRO30.74250100
63MAP3K40.71624921
64CSNK1A1L0.71472157
65BRAF0.70580598
66SRPK10.68006106
67PDK10.67388368
68BMPR1B0.66190142
69TEC0.66118265
70NTRK30.65093940
71STK160.65072617
72WNK10.64556825
73ERBB30.63148282
74CDK30.62794392
75IKBKB0.62764426
76PINK10.61166728
77PRKCI0.57805363
78PRKCQ0.57652099
79NLK0.56292830
80CAMK10.55580877
81FER0.54775403
82MAP3K60.54470469
83RPS6KA50.53602171
84EEF2K0.52982674
85CAMK2A0.52774864
86CDK80.51532384
87PIK3CA0.51243431
88BCKDK0.50741646
89MAPKAPK30.50427631
90IRAK10.49169085
91EPHA30.48502510
92ZAK0.48254376
93PLK30.47845354
94AURKB0.47729460
95CDK190.47208177
96CAMKK20.46577601
97MAP2K70.46421051
98PIK3CG0.45608141
99CDK70.45264500
100PKN10.44767859
101CDK40.43663484
102PRKG10.43148187
103EIF2AK30.43131676
104LATS10.42421188
105NEK60.42417862
106AURKA0.42118855
107FGFR20.41540794
108CDK90.41403008
109TNK20.41300655
110PRKACA0.41225855
111LMTK20.39427611
112STK100.37002416
113BRSK10.36655860
114SIK20.33942319
115EPHA40.33921724
116MAP2K40.33422695
117MAP2K60.33010786
118MKNK10.32739128
119CSNK1A10.32523809
120BRD40.32329251
121CAMK1G0.32059729
122PRKCZ0.31973924
123GRK50.31932575
124PRKAA20.31756743
125CHUK0.31583716
126MAP2K20.30559268
127STK110.30491000
128CDK20.29970041
129CDK10.29843711
130PRKCA0.29700261
131TRPM70.29449556
132PAK10.27468220
133PRKAA10.26307957
134MELK0.24107833
135VRK10.24081789
136MTOR0.23523037
137YES10.22071415
138RPS6KB10.22068848
139CSNK2A10.21612497
140MAPKAPK50.19348581
141STK40.17927952
142TGFBR20.16815262
143CDK60.16782297
144TGFBR10.16660516
145STK240.15851583
146CSNK2A20.14967789
147GSK3B0.13737477
148BMPR20.13158755
149EIF2AK20.12922256
150LATS20.12626628
151PRKDC0.11547864
152MOS0.11132259
153GRK70.10832698
154PIM10.10446844
155PRKACB0.07947216
156MKNK20.07738628
157DYRK20.07092568
158AKT30.06701980
159MAPK10.06172953
160WNK30.05202460
161MARK20.04673358
162CSNK1D0.04564490
163MAPK80.04465807
164MAPK140.04406350
165RPS6KA40.03085866
166PAK20.02789419
167CSNK1E0.02676944

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.36650465
2Vitamin B6 metabolism_Homo sapiens_hsa007504.31377113
3Fanconi anemia pathway_Homo sapiens_hsa034603.84695496
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21815740
5Pyruvate metabolism_Homo sapiens_hsa006203.20267350
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.09212349
7Butanoate metabolism_Homo sapiens_hsa006502.84387133
8Phototransduction_Homo sapiens_hsa047442.76482782
9RNA transport_Homo sapiens_hsa030132.60465825
10Homologous recombination_Homo sapiens_hsa034402.60221750
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.57027259
12Cell cycle_Homo sapiens_hsa041102.54146770
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48483506
14Propanoate metabolism_Homo sapiens_hsa006402.40423989
15DNA replication_Homo sapiens_hsa030302.32167099
16Pentose phosphate pathway_Homo sapiens_hsa000302.30405449
17mRNA surveillance pathway_Homo sapiens_hsa030152.28734997
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28436091
19Linoleic acid metabolism_Homo sapiens_hsa005912.26491465
20Oocyte meiosis_Homo sapiens_hsa041142.24212196
21Dorso-ventral axis formation_Homo sapiens_hsa043202.20680557
22Selenocompound metabolism_Homo sapiens_hsa004502.20526072
23Nicotine addiction_Homo sapiens_hsa050332.17784783
24Mismatch repair_Homo sapiens_hsa034302.14367088
25Nitrogen metabolism_Homo sapiens_hsa009102.11519650
26Fatty acid biosynthesis_Homo sapiens_hsa000612.09165976
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07515812
28Glucagon signaling pathway_Homo sapiens_hsa049221.89505383
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87205025
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85042930
31RNA degradation_Homo sapiens_hsa030181.83872148
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82064506
33Nucleotide excision repair_Homo sapiens_hsa034201.79837305
34Tryptophan metabolism_Homo sapiens_hsa003801.76097781
35Olfactory transduction_Homo sapiens_hsa047401.73683245
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72802646
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.71977530
38Protein export_Homo sapiens_hsa030601.68870638
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67231184
40Huntingtons disease_Homo sapiens_hsa050161.65115394
41Caffeine metabolism_Homo sapiens_hsa002321.63261126
42Purine metabolism_Homo sapiens_hsa002301.59453501
43Oxidative phosphorylation_Homo sapiens_hsa001901.58932955
44Non-homologous end-joining_Homo sapiens_hsa034501.53162379
45Taste transduction_Homo sapiens_hsa047421.49980722
46Pyrimidine metabolism_Homo sapiens_hsa002401.48608942
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45307857
48Morphine addiction_Homo sapiens_hsa050321.44896733
49Base excision repair_Homo sapiens_hsa034101.44801299
50Spliceosome_Homo sapiens_hsa030401.43588139
51Glycerolipid metabolism_Homo sapiens_hsa005611.40472873
52beta-Alanine metabolism_Homo sapiens_hsa004101.33360792
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31531700
54Peroxisome_Homo sapiens_hsa041461.30361680
55Glycerophospholipid metabolism_Homo sapiens_hsa005641.28247401
56Insulin secretion_Homo sapiens_hsa049111.26712949
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.22444920
58Circadian entrainment_Homo sapiens_hsa047131.20688387
59Parkinsons disease_Homo sapiens_hsa050121.20182143
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19843054
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18741372
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16993016
63Regulation of autophagy_Homo sapiens_hsa041401.12414551
64Ether lipid metabolism_Homo sapiens_hsa005651.10643007
65Serotonergic synapse_Homo sapiens_hsa047261.10602267
66p53 signaling pathway_Homo sapiens_hsa041151.10420609
67Antigen processing and presentation_Homo sapiens_hsa046121.06192733
68GABAergic synapse_Homo sapiens_hsa047271.05989670
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05796128
70Glycosaminoglycan degradation_Homo sapiens_hsa005311.04861850
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03134186
72Glutamatergic synapse_Homo sapiens_hsa047241.01918598
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99765313
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98749350
75Carbon metabolism_Homo sapiens_hsa012000.97847448
76Fructose and mannose metabolism_Homo sapiens_hsa000510.95164694
77Biosynthesis of amino acids_Homo sapiens_hsa012300.94302112
78Collecting duct acid secretion_Homo sapiens_hsa049660.85022649
79PPAR signaling pathway_Homo sapiens_hsa033200.83768702
80Salivary secretion_Homo sapiens_hsa049700.81057125
81Arachidonic acid metabolism_Homo sapiens_hsa005900.78625227
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77959286
83Fatty acid elongation_Homo sapiens_hsa000620.74751011
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74421459
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.73521682
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72064823
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68520653
88Sulfur metabolism_Homo sapiens_hsa009200.66508076
89Type I diabetes mellitus_Homo sapiens_hsa049400.64053754
90Alzheimers disease_Homo sapiens_hsa050100.62296970
91Glutathione metabolism_Homo sapiens_hsa004800.62257197
92N-Glycan biosynthesis_Homo sapiens_hsa005100.61810714
93Long-term depression_Homo sapiens_hsa047300.59284717
94Amphetamine addiction_Homo sapiens_hsa050310.58308272
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56540629
96Systemic lupus erythematosus_Homo sapiens_hsa053220.56506667
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56274614
98Circadian rhythm_Homo sapiens_hsa047100.55936770
99Epstein-Barr virus infection_Homo sapiens_hsa051690.55512989
100Viral carcinogenesis_Homo sapiens_hsa052030.54493068
101Proteasome_Homo sapiens_hsa030500.54488610
102Dopaminergic synapse_Homo sapiens_hsa047280.53419127
103ABC transporters_Homo sapiens_hsa020100.53341984
104Arginine and proline metabolism_Homo sapiens_hsa003300.52032572
105RNA polymerase_Homo sapiens_hsa030200.51737428
106Herpes simplex infection_Homo sapiens_hsa051680.49860804
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49667360
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49596482
109Fatty acid degradation_Homo sapiens_hsa000710.48837620
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48192964
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46620476
112Retinol metabolism_Homo sapiens_hsa008300.46346723
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45831840
114Hedgehog signaling pathway_Homo sapiens_hsa043400.45592520
115Metabolic pathways_Homo sapiens_hsa011000.45408991
116Ovarian steroidogenesis_Homo sapiens_hsa049130.44812184
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.43580182
118Fatty acid metabolism_Homo sapiens_hsa012120.43495946
119Asthma_Homo sapiens_hsa053100.43267809
120Synaptic vesicle cycle_Homo sapiens_hsa047210.42651863
121Histidine metabolism_Homo sapiens_hsa003400.42481598
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.41912066
123Renin secretion_Homo sapiens_hsa049240.41280950
124Mineral absorption_Homo sapiens_hsa049780.40362262
125cAMP signaling pathway_Homo sapiens_hsa040240.39630100
126Cardiac muscle contraction_Homo sapiens_hsa042600.39479894
127Lysine degradation_Homo sapiens_hsa003100.39235437
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39109834
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38359313
130Sulfur relay system_Homo sapiens_hsa041220.38216379
131Chemical carcinogenesis_Homo sapiens_hsa052040.37962104
132HTLV-I infection_Homo sapiens_hsa051660.36242602
133AMPK signaling pathway_Homo sapiens_hsa041520.34022289
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.34001760
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31106045
136Steroid biosynthesis_Homo sapiens_hsa001000.30580737
137Fat digestion and absorption_Homo sapiens_hsa049750.30164634
138Inositol phosphate metabolism_Homo sapiens_hsa005620.27231702
139Renin-angiotensin system_Homo sapiens_hsa046140.24828378
140Legionellosis_Homo sapiens_hsa051340.23885047
141Wnt signaling pathway_Homo sapiens_hsa043100.22620537
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21606372
143Estrogen signaling pathway_Homo sapiens_hsa049150.19017909
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18571946
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.18514300
146Influenza A_Homo sapiens_hsa051640.16272264
147Basal cell carcinoma_Homo sapiens_hsa052170.16251592
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16236995
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15923627
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15348203
151One carbon pool by folate_Homo sapiens_hsa006700.13440894
152TGF-beta signaling pathway_Homo sapiens_hsa043500.13137204
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12889995
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12363265
155Calcium signaling pathway_Homo sapiens_hsa040200.12156045
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11370607
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10672107
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09977113
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.09396867
160Sphingolipid metabolism_Homo sapiens_hsa006000.08652914

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