CCDC159

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.32650977
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.92149609
3L-phenylalanine catabolic process (GO:0006559)4.92149609
4acrosome reaction (GO:0007340)4.62755656
5L-phenylalanine metabolic process (GO:0006558)4.60187741
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.60187741
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.56562329
8fusion of sperm to egg plasma membrane (GO:0007342)4.35833176
9activated T cell proliferation (GO:0050798)4.35243593
10cell wall macromolecule catabolic process (GO:0016998)4.24974152
11cell wall macromolecule metabolic process (GO:0044036)4.24974152
12interferon-gamma production (GO:0032609)4.06841336
13negative regulation of cell killing (GO:0031342)4.00483215
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00483215
15acrosome assembly (GO:0001675)3.92133070
16positive regulation of gamma-delta T cell activation (GO:0046645)3.87839022
17aromatic amino acid family catabolic process (GO:0009074)3.84389670
18regulation of isotype switching to IgG isotypes (GO:0048302)3.75852850
19sperm-egg recognition (GO:0035036)3.69144147
20alpha-linolenic acid metabolic process (GO:0036109)3.67105741
21calcium ion-dependent exocytosis (GO:0017156)3.61014484
22regulation of cilium movement (GO:0003352)3.61013508
23regulation of B cell receptor signaling pathway (GO:0050855)3.57726354
24plasma membrane fusion (GO:0045026)3.52441386
25positive regulation of T cell mediated cytotoxicity (GO:0001916)3.52328213
26mast cell activation (GO:0045576)3.48484934
27regulation of T cell mediated cytotoxicity (GO:0001914)3.47681060
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.46978971
29negative regulation of interleukin-12 production (GO:0032695)3.46156334
30kynurenine metabolic process (GO:0070189)3.39369787
31neutrophil activation involved in immune response (GO:0002283)3.37966748
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34461419
33positive regulation of defense response to virus by host (GO:0002230)3.33603680
34positive regulation of isotype switching (GO:0045830)3.33092742
35organic cation transport (GO:0015695)3.31954330
36multicellular organism reproduction (GO:0032504)3.31333907
37cell-cell recognition (GO:0009988)3.29230360
38tryptophan catabolic process (GO:0006569)3.26887325
39indole-containing compound catabolic process (GO:0042436)3.26887325
40indolalkylamine catabolic process (GO:0046218)3.26887325
41binding of sperm to zona pellucida (GO:0007339)3.26691336
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26254085
43regulation of gamma-delta T cell activation (GO:0046643)3.24190244
44urea cycle (GO:0000050)3.24163830
45urea metabolic process (GO:0019627)3.24163830
46tryptophan metabolic process (GO:0006568)3.23344952
47tyrosine metabolic process (GO:0006570)3.21830721
48immunoglobulin mediated immune response (GO:0016064)3.21392655
49positive regulation of DNA recombination (GO:0045911)3.20418931
50bile acid biosynthetic process (GO:0006699)3.20008380
51spermatid development (GO:0007286)3.18735609
52mast cell degranulation (GO:0043303)3.16628061
53mast cell activation involved in immune response (GO:0002279)3.16628061
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14989845
55response to interferon-beta (GO:0035456)3.14131515
56high-density lipoprotein particle remodeling (GO:0034375)3.13539466
57antigen processing and presentation of endogenous antigen (GO:0019883)3.13416128
58lactate metabolic process (GO:0006089)3.11681995
59negative regulation of T cell mediated immunity (GO:0002710)3.10713351
60leukocyte aggregation (GO:0070486)3.10341197
61cellular response to interleukin-15 (GO:0071350)3.09748903
62positive regulation of B cell mediated immunity (GO:0002714)3.08634872
63positive regulation of immunoglobulin mediated immune response (GO:0002891)3.08634872
64reproduction (GO:0000003)3.06989800
65cellular ketone body metabolic process (GO:0046950)3.06530285
66regulation of germinal center formation (GO:0002634)3.03285202
67neutrophil activation (GO:0042119)3.02655458
68RNA destabilization (GO:0050779)3.02304872
69cellular response to interferon-beta (GO:0035458)3.00568264
70nitrogen cycle metabolic process (GO:0071941)3.00347113
71epithelial cilium movement (GO:0003351)2.98150942
72negative regulation of lymphocyte mediated immunity (GO:0002707)2.96986686
73sulfur amino acid catabolic process (GO:0000098)2.93190230
74DNA deamination (GO:0045006)2.92673083
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.91297043
76leukocyte degranulation (GO:0043299)2.90846035
77aromatic amino acid family metabolic process (GO:0009072)2.90560179
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89993728
79fructose metabolic process (GO:0006000)2.89500942
80defense response to protozoan (GO:0042832)2.89013808
81macroautophagy (GO:0016236)2.84663326
82complement activation, alternative pathway (GO:0006957)2.83492578
83macrophage activation involved in immune response (GO:0002281)2.82261497
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.81620621
85amino-acid betaine metabolic process (GO:0006577)2.79990864
86myeloid cell activation involved in immune response (GO:0002275)2.79984550
87protein carboxylation (GO:0018214)2.79698521
88peptidyl-glutamic acid carboxylation (GO:0017187)2.79698521
89reverse cholesterol transport (GO:0043691)2.78722270
90regulation of gamma-delta T cell differentiation (GO:0045586)2.78596276
91bile acid metabolic process (GO:0008206)2.77542655
92positive regulation of glycolytic process (GO:0045821)2.75788370
93response to interleukin-15 (GO:0070672)2.75440139
94glyoxylate metabolic process (GO:0046487)2.75413216
95protein polyglutamylation (GO:0018095)2.74225333
96positive regulation of immunoglobulin production (GO:0002639)2.74076173
97regulation of cholesterol esterification (GO:0010872)2.73110423
98regulation of microtubule-based movement (GO:0060632)2.72291070
99aspartate family amino acid catabolic process (GO:0009068)2.71307663
100sperm capacitation (GO:0048240)2.71067046
101regulation of leukocyte mediated cytotoxicity (GO:0001910)2.69825908
102negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69685895
103negative regulation of T-helper cell differentiation (GO:0045623)2.69685895
104synaptic vesicle exocytosis (GO:0016079)2.69049135
105microglial cell activation (GO:0001774)2.68803466
106regulation of regulatory T cell differentiation (GO:0045589)2.68631984
107dicarboxylic acid biosynthetic process (GO:0043650)2.68464994
108interferon-gamma-mediated signaling pathway (GO:0060333)2.68360140
109pyrimidine nucleobase catabolic process (GO:0006208)2.67871028
110lysine metabolic process (GO:0006553)2.67756718
111lysine catabolic process (GO:0006554)2.67756718
112cellular modified amino acid catabolic process (GO:0042219)2.67752943
113plasma lipoprotein particle remodeling (GO:0034369)2.67721263
114protein-lipid complex remodeling (GO:0034368)2.67721263
115macromolecular complex remodeling (GO:0034367)2.67721263
116cellular response to exogenous dsRNA (GO:0071360)2.67438905
117locomotory exploration behavior (GO:0035641)2.66962251
118granulocyte activation (GO:0036230)2.66571710
119glutamate metabolic process (GO:0006536)2.66188357
120coenzyme catabolic process (GO:0009109)2.64738001
121indolalkylamine metabolic process (GO:0006586)2.64622724
122negative regulation of interleukin-1 beta production (GO:0032691)2.64300490
123response to type I interferon (GO:0034340)2.63928629
124negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.63829972
125response to protozoan (GO:0001562)2.63366178
126ketone body metabolic process (GO:1902224)2.62779832
127regulation of T cell mediated immunity (GO:0002709)2.62723289
128leukotriene biosynthetic process (GO:0019370)2.62515465
129cellular response to type I interferon (GO:0071357)2.62225312
130type I interferon signaling pathway (GO:0060337)2.62225312
131regulation of inclusion body assembly (GO:0090083)2.62053567
132cilium or flagellum-dependent cell motility (GO:0001539)2.61846215
133alpha-amino acid catabolic process (GO:1901606)2.61019119
134tolerance induction (GO:0002507)2.60030356
135negative regulation of interleukin-1 production (GO:0032692)2.59865556
136negative regulation of fibrinolysis (GO:0051918)2.59539532
137positive regulation of antigen processing and presentation (GO:0002579)2.59481763
138positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.58691044
139axonemal dynein complex assembly (GO:0070286)2.58004227
140regulation of immunoglobulin mediated immune response (GO:0002889)2.57722427
141regulation of fibrinolysis (GO:0051917)2.57260922
142negative regulation of alpha-beta T cell activation (GO:0046636)2.56970348
143negative regulation of inclusion body assembly (GO:0090084)2.56720098
144positive regulation of calcium-mediated signaling (GO:0050850)2.56227384
145response to peptidoglycan (GO:0032494)2.56185011
146regulation of B cell mediated immunity (GO:0002712)2.55795198
147positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.54871449
148positive regulation of mast cell activation (GO:0033005)2.54301655
149regulation of defense response to virus by host (GO:0050691)2.53821098
150NAD biosynthetic process (GO:0009435)2.53391177
151regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52568238
152acylglycerol homeostasis (GO:0055090)2.52218133
153triglyceride homeostasis (GO:0070328)2.52218133
154negative regulation of sterol transport (GO:0032372)2.52160991
155negative regulation of cholesterol transport (GO:0032375)2.52160991
156antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51838790
157positive regulation of lymphocyte mediated immunity (GO:0002708)2.51345187
158regulation of mast cell activation (GO:0033003)2.50978168
159carnitine metabolic process (GO:0009437)2.50959421
160cellular amino acid catabolic process (GO:0009063)2.50909556
161regulation of isotype switching (GO:0045191)2.50848534
162platelet dense granule organization (GO:0060155)2.50687638
163regulation of cell killing (GO:0031341)2.50683411
164positive regulation of T cell mediated immunity (GO:0002711)2.49538936
165regulation of adaptive immune response based on somatic recombination of immune receptors built from2.49072805
166cilium movement (GO:0003341)2.48684594
167peptidyl-glutamic acid modification (GO:0018200)2.48288892
168regulation of antigen processing and presentation (GO:0002577)2.47958491
169regulation of lymphocyte mediated immunity (GO:0002706)2.47632509
170regulation of protein activation cascade (GO:2000257)2.47314463
171motile cilium assembly (GO:0044458)2.46462150
172response to pheromone (GO:0019236)2.46267463
173regulation of hypersensitivity (GO:0002883)2.46183314
174ether metabolic process (GO:0018904)2.45698613
175positive regulation of adaptive immune response (GO:0002821)2.44787734
176negative regulation of adaptive immune response (GO:0002820)2.44701447
177glutamate secretion (GO:0014047)2.44552052
178regulation of triglyceride catabolic process (GO:0010896)2.44161847
179positive regulation of fatty acid beta-oxidation (GO:0032000)2.44108152
180negative regulation of leukocyte mediated immunity (GO:0002704)2.43944275
181regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.43804411
182detection of bacterium (GO:0016045)2.42951709
183vocalization behavior (GO:0071625)2.41509638
184regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.41223903
185regulation of fatty acid beta-oxidation (GO:0031998)2.40473178
186base-excision repair, AP site formation (GO:0006285)2.40387845
187regulation of adaptive immune response (GO:0002819)2.40351185
188neurotransmitter-gated ion channel clustering (GO:0072578)2.39796052
189glycolytic process (GO:0006096)2.39608680
190short-chain fatty acid metabolic process (GO:0046459)2.38589656
191benzene-containing compound metabolic process (GO:0042537)2.38439020
192plasma lipoprotein particle clearance (GO:0034381)2.38212357
193regulation of synaptic vesicle exocytosis (GO:2000300)2.37764720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.08022149
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.13444490
3EZH2_22144423_ChIP-Seq_EOC_Human4.07241305
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.34462057
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05519273
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96525437
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.84703302
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81572096
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.81093183
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67093002
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66569187
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.64124048
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.58193546
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50069915
15* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46524844
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41237649
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39915670
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33211874
19REST_21632747_ChIP-Seq_MESCs_Mouse2.26948646
20RUNX_20019798_ChIP-Seq_JUKART_Human2.26442572
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18569767
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15401981
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13385408
24GBX2_23144817_ChIP-Seq_PC3_Human2.10885504
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89020755
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85872664
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81766830
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.76572254
29ZNF274_21170338_ChIP-Seq_K562_Hela1.75931799
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75711227
31GATA3_26560356_Chip-Seq_TH2_Human1.71361358
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70493915
33GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.67911581
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.67317529
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67130702
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66273365
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64694372
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.64447159
39BCL6_27268052_Chip-Seq_Bcells_Human1.61189083
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61110366
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60824947
42DROSHA_22980978_ChIP-Seq_HELA_Human1.60603833
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59458637
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56055174
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55436592
46MYB_26560356_Chip-Seq_TH2_Human1.53956665
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53528612
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50947471
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.48091338
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.47301786
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46919791
52SCL_19346495_ChIP-Seq_HPC-7_Human1.45927548
53VDR_24787735_ChIP-Seq_THP-1_Human1.44969413
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44328913
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43516319
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.39886636
57TAF15_26573619_Chip-Seq_HEK293_Human1.39816543
58SPI1_23547873_ChIP-Seq_NB4_Human1.38730249
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37162563
60GATA3_27048872_Chip-Seq_THYMUS_Human1.36258691
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33036538
62NANOG_20526341_ChIP-Seq_ESCs_Human1.31522547
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29580755
64ERA_21632823_ChIP-Seq_H3396_Human1.29560244
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28450677
66* TAF2_19829295_ChIP-Seq_ESCs_Human1.28403504
67BCOR_27268052_Chip-Seq_Bcells_Human1.28304805
68STAT1_20625510_ChIP-Seq_HELA_Human1.28184955
69E2F1_20622854_ChIP-Seq_HELA_Human1.28049006
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27832084
71SPI1_23127762_ChIP-Seq_K562_Human1.26700336
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26278122
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25730750
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.25662782
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25491188
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.23451135
77P300_27268052_Chip-Seq_Bcells_Human1.22811365
78SMAD4_21799915_ChIP-Seq_A2780_Human1.22454388
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22364164
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21853187
81VDR_22108803_ChIP-Seq_LS180_Human1.20905829
82VDR_24763502_ChIP-Seq_THP-1_Human1.20570541
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20300987
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20106459
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19312088
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17902992
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17868009
88MYC_19829295_ChIP-Seq_ESCs_Human1.17523801
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17215782
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16503977
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15723068
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14929929
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13623129
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13623129
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13475254
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13281680
97OCT4_20526341_ChIP-Seq_ESCs_Human1.13217356
98RAC3_21632823_ChIP-Seq_H3396_Human1.12140752
99MYB_26560356_Chip-Seq_TH1_Human1.10582280
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10521598
101MAF_26560356_Chip-Seq_TH1_Human1.10290064
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08840984
103CBP_20019798_ChIP-Seq_JUKART_Human1.08046525
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08046525
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07888121
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07605905
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.07194180
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06287184
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05603102
110KDM2B_26808549_Chip-Seq_REH_Human1.05238164
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05144879
112UTX_26944678_Chip-Seq_JUKART_Human1.04668901
113HTT_18923047_ChIP-ChIP_STHdh_Human1.04668310
114AR_25329375_ChIP-Seq_VCAP_Human1.04001634
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03898313
116SPI1_20517297_ChIP-Seq_HL60_Human1.03855835
117PHF8_20622854_ChIP-Seq_HELA_Human1.03716324
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03714766
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03445261
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.03358732
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01811413
122FOXH1_21741376_ChIP-Seq_ESCs_Human1.01272584
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01088322
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01071584
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.00958660
126BCAT_22108803_ChIP-Seq_LS180_Human1.00373576
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00239145
128CTCF_20526341_ChIP-Seq_ESCs_Human1.00096899
129SOX2_21211035_ChIP-Seq_LN229_Gbm1.00062671
130AR_20517297_ChIP-Seq_VCAP_Human0.99653877
131ER_23166858_ChIP-Seq_MCF-7_Human0.99429505
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98766572
133MAF_26560356_Chip-Seq_TH2_Human0.98696566
134TP53_22573176_ChIP-Seq_HFKS_Human0.98682602
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98393092
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98003331
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97212029
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97042347
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96278600
140FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96164124
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.96164124
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95853346
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95805465
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.95718547
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95599785
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.94980798
147P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.94679061
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94651554
149P300_19829295_ChIP-Seq_ESCs_Human0.93954094
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93657674
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.93598059
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92780222
153STAT3_23295773_ChIP-Seq_U87_Human0.92002018
154SMRT_27268052_Chip-Seq_Bcells_Human0.91921862
155EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91341960
156SOX2_19829295_ChIP-Seq_ESCs_Human0.91187061
157NANOG_19829295_ChIP-Seq_ESCs_Human0.91187061
158P68_20966046_ChIP-Seq_HELA_Human0.91004726
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90743345
160TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90720916
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.90627763
162VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90527015
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90173442
164* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89899146
165HOXB7_26014856_ChIP-Seq_BT474_Human0.89491617
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89276090
167NCOR_22424771_ChIP-Seq_293T_Human0.89071599
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88599398
169PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88240136
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87755733
171SMAD4_21741376_ChIP-Seq_EPCs_Human0.86823271
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.86473129
173CTCF_27219007_Chip-Seq_Bcells_Human0.86134166
174WDR5_24793694_ChIP-Seq_LNCAP_Human0.84395245
175SMAD3_21741376_ChIP-Seq_ESCs_Human0.83637117
176SMAD3_21741376_ChIP-Seq_EPCs_Human0.83510418
177TCF4_23295773_ChIP-Seq_U87_Human0.83244946
178SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82407651
179NANOG_18555785_Chip-Seq_ESCs_Mouse0.82330697
180RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82280867
181TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81835148
182EP300_21415370_ChIP-Seq_HL-1_Mouse0.81537710
183EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81518034
184SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80938195
185ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80131602
186UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79668469
187AR_19668381_ChIP-Seq_PC3_Human0.79667499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.95680511
2MP0002139_abnormal_hepatobiliary_system4.63304564
3MP0005365_abnormal_bile_salt3.69653448
4MP0005360_urolithiasis3.56477819
5MP0003724_increased_susceptibility_to3.50339781
6MP0005085_abnormal_gallbladder_physiolo3.46667475
7MP0005671_abnormal_response_to3.32688332
8MP0006082_CNS_inflammation3.32532556
9MP0003436_decreased_susceptibility_to3.16195461
10MP0008875_abnormal_xenobiotic_pharmacok2.90637162
11MP0001835_abnormal_antigen_presentation2.83662090
12MP0002837_dystrophic_cardiac_calcinosis2.82125424
13MP0009785_altered_susceptibility_to2.78028898
14MP0004859_abnormal_synaptic_plasticity2.53484538
15MP0005000_abnormal_immune_tolerance2.52596995
16MP0001800_abnormal_humoral_immune2.52194816
17MP0002132_abnormal_respiratory_system2.50807049
18MP0000685_abnormal_immune_system2.38364701
19MP0002148_abnormal_hypersensitivity_rea2.30099898
20MP0005025_abnormal_response_to2.29658181
21MP0001790_abnormal_immune_system2.28272713
22MP0005387_immune_system_phenotype2.28272713
23MP0003195_calcinosis2.26598089
24MP0010329_abnormal_lipoprotein_level2.26297964
25MP0002723_abnormal_immune_serum2.26279134
26MP0002419_abnormal_innate_immunity2.26155387
27MP0002909_abnormal_adrenal_gland2.24698524
28MP0002822_catalepsy2.14035294
29MP0000013_abnormal_adipose_tissue2.09614506
30MP0002452_abnormal_antigen_presenting2.08585871
31MP0003806_abnormal_nucleotide_metabolis2.06078456
32MP0002138_abnormal_hepatobiliary_system2.05967236
33MP0002420_abnormal_adaptive_immunity1.98052876
34MP0001819_abnormal_immune_cell1.96796276
35MP0003252_abnormal_bile_duct1.96429498
36MP0005167_abnormal_blood-brain_barrier1.94120751
37MP0009764_decreased_sensitivity_to1.92283748
38MP0004270_analgesia1.90451607
39MP0003635_abnormal_synaptic_transmissio1.89980016
40MP0003303_peritoneal_inflammation1.89705441
41MP0002405_respiratory_system_inflammati1.86307447
42MP0005670_abnormal_white_adipose1.81854939
43MP0003329_amyloid_beta_deposits1.81533879
44MP0001984_abnormal_olfaction1.76610053
45MP0010386_abnormal_urinary_bladder1.74482442
46MP0010155_abnormal_intestine_physiology1.68981766
47MP0003698_abnormal_male_reproductive1.68931243
48MP0001533_abnormal_skeleton_physiology1.67097784
49MP0001845_abnormal_inflammatory_respons1.61675691
50MP0005332_abnormal_amino_acid1.59111203
51MP0001873_stomach_inflammation1.57755008
52MP0008469_abnormal_protein_level1.55857152
53MP0009840_abnormal_foam_cell1.55580811
54MP0002063_abnormal_learning/memory/cond1.55034420
55MP0009780_abnormal_chondrocyte_physiolo1.55012379
56MP0009745_abnormal_behavioral_response1.53070000
57MP0002118_abnormal_lipid_homeostasis1.52338632
58MP0001986_abnormal_taste_sensitivity1.51651669
59MP0009046_muscle_twitch1.51506219
60MP0004043_abnormal_pH_regulation1.51000552
61MP0003283_abnormal_digestive_organ1.47665108
62MP0002064_seizures1.47414703
63MP0003880_abnormal_central_pattern1.46002394
64MP0005083_abnormal_biliary_tract1.44600550
65MP0002572_abnormal_emotion/affect_behav1.43955206
66MP0005646_abnormal_pituitary_gland1.42183848
67MP0000716_abnormal_immune_system1.41547890
68MP0003183_abnormal_peptide_metabolism1.39718289
69MP0003300_gastrointestinal_ulcer1.38917985
70MP0003763_abnormal_thymus_physiology1.38306089
71MP0001968_abnormal_touch/_nociception1.35321510
72MP0001501_abnormal_sleep_pattern1.32968092
73MP0003878_abnormal_ear_physiology1.31553801
74MP0005377_hearing/vestibular/ear_phenot1.31553801
75MP0002653_abnormal_ependyma_morphology1.29122716
76MP0005535_abnormal_body_temperature1.29106139
77MP0002277_abnormal_respiratory_mucosa1.28610162
78MP0002398_abnormal_bone_marrow1.26394128
79MP0006276_abnormal_autonomic_nervous1.26139298
80MP0001440_abnormal_grooming_behavior1.25158425
81MP0002078_abnormal_glucose_homeostasis1.24920245
82MP0005310_abnormal_salivary_gland1.24018290
83MP0001502_abnormal_circadian_rhythm1.23910667
84MP0002272_abnormal_nervous_system1.21502789
85MP0005379_endocrine/exocrine_gland_phen1.21265085
86MP0002734_abnormal_mechanical_nocicepti1.20773850
87MP0005645_abnormal_hypothalamus_physiol1.19519437
88MP0005551_abnormal_eye_electrophysiolog1.19199384
89MP0002736_abnormal_nociception_after1.19184137
90MP0004142_abnormal_muscle_tone1.18467782
91MP0000689_abnormal_spleen_morphology1.17996519
92MP0000465_gastrointestinal_hemorrhage1.16936994
93MP0001929_abnormal_gametogenesis1.16391065
94MP0003866_abnormal_defecation1.15740065
95MP0002733_abnormal_thermal_nociception1.15288261
96MP0002090_abnormal_vision1.14054031
97MP0000604_amyloidosis1.13899839
98MP0009333_abnormal_splenocyte_physiolog1.13783789
99MP0002254_reproductive_system_inflammat1.13459684
100MP0001486_abnormal_startle_reflex1.11545013
101MP0005075_abnormal_melanosome_morpholog1.10905263
102MP0004130_abnormal_muscle_cell1.10426223
103MP0009278_abnormal_bone_marrow1.10406276
104MP0000569_abnormal_digit_pigmentation1.09303916
105MP0004858_abnormal_nervous_system1.08200128
106MP0005464_abnormal_platelet_physiology1.07767970
107MP0008872_abnormal_physiological_respon1.05164970
108MP0003011_delayed_dark_adaptation1.04062116
109MP0002234_abnormal_pharynx_morphology1.03919420
110MP0003868_abnormal_feces_composition1.03032261
111MP0002429_abnormal_blood_cell1.02171806
112MP0002722_abnormal_immune_system1.01521765
113MP0009697_abnormal_copulation1.00553306
114MP0002876_abnormal_thyroid_physiology1.00466484
115MP0002735_abnormal_chemical_nociception0.99461364
116MP0001666_abnormal_nutrient_absorption0.99216073
117MP0000609_abnormal_liver_physiology0.99103362
118MP0002933_joint_inflammation0.98687594
119MP0003646_muscle_fatigue0.98440517
120MP0002557_abnormal_social/conspecific_i0.97942889
121MP0003633_abnormal_nervous_system0.97536146
122MP0005084_abnormal_gallbladder_morpholo0.97250558
123MP0004019_abnormal_vitamin_homeostasis0.96518749
124MP0001944_abnormal_pancreas_morphology0.96053600
125MP0003045_fibrosis0.93610285
126MP0003787_abnormal_imprinting0.93355868
127MP0001663_abnormal_digestive_system0.93294020
128MP0002693_abnormal_pancreas_physiology0.91555168
129MP0005584_abnormal_enzyme/coenzyme_acti0.90414649
130MP0001764_abnormal_homeostasis0.90387061
131MP0004947_skin_inflammation0.90016994
132MP0005647_abnormal_sex_gland0.88832080
133MP0002067_abnormal_sensory_capabilities0.88819119
134MP0005319_abnormal_enzyme/_coenzyme0.88087747
135MP0002161_abnormal_fertility/fecundity0.87835273
136MP0005636_abnormal_mineral_homeostasis0.86200580
137MP0001970_abnormal_pain_threshold0.85788695
138MP0003953_abnormal_hormone_level0.85648953
139MP0003172_abnormal_lysosome_physiology0.84723998
140MP0004811_abnormal_neuron_physiology0.84569736
141MP0001765_abnormal_ion_homeostasis0.84072918
142MP0004233_abnormal_muscle_weight0.83970321
143MP0006072_abnormal_retinal_apoptosis0.83688645
144MP0003122_maternal_imprinting0.83360767
145MP0003075_altered_response_to0.82701711
146MP0004883_abnormal_blood_vessel0.81786945
147MP0000955_abnormal_spinal_cord0.81727925
148MP0000230_abnormal_systemic_arterial0.81726191
149MP0004885_abnormal_endolymph0.81273838
150MP0002928_abnormal_bile_duct0.77666993
151MP0005448_abnormal_energy_balance0.77318606
152MP0000703_abnormal_thymus_morphology0.76739880
153MP0000639_abnormal_adrenal_gland0.76403909
154MP0005397_hematopoietic_system_phenotyp0.74975851
155MP0001545_abnormal_hematopoietic_system0.74975851
156MP0003879_abnormal_hair_cell0.74592172
157MP0005386_behavior/neurological_phenoty0.74325445
158MP0004924_abnormal_behavior0.74325445
159MP0002069_abnormal_eating/drinking_beha0.74289227
160MP0003638_abnormal_response/metabolism_0.74284470
161MP0004510_myositis0.73570719
162MP0002066_abnormal_motor_capabilities/c0.72997567
163MP0003631_nervous_system_phenotype0.71639745
164MP0004085_abnormal_heartbeat0.71406154
165MP0000538_abnormal_urinary_bladder0.71118127
166MP0003690_abnormal_glial_cell0.70672335
167MP0001905_abnormal_dopamine_level0.70371938
168MP0000003_abnormal_adipose_tissue0.70198284
169MP0002229_neurodegeneration0.70057040
170MP0003191_abnormal_cellular_cholesterol0.69606139
171MP0005253_abnormal_eye_physiology0.69121005
172MP0008961_abnormal_basal_metabolism0.69014184
173MP0003828_pulmonary_edema0.67637192
174MP0002998_abnormal_bone_remodeling0.67520788
175MP0005058_abnormal_lysosome_morphology0.66683114
176MP0000858_altered_metastatic_potential0.64454031

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.02453452
2Myositis (HP:0100614)4.99078833
3Absent/shortened dynein arms (HP:0200106)4.77929981
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.77929981
5Stomatitis (HP:0010280)4.76071086
6Hypoglycemic seizures (HP:0002173)4.54124834
7Prolonged partial thromboplastin time (HP:0003645)4.53606766
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.45912755
9Optic neuritis (HP:0100653)4.33517022
10Retrobulbar optic neuritis (HP:0100654)4.33517022
11Hyperinsulinemic hypoglycemia (HP:0000825)4.30836015
12Orchitis (HP:0100796)4.09044084
13Hypoglycemic coma (HP:0001325)4.04883435
14Ketosis (HP:0001946)4.00309387
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.94237286
16Intrahepatic cholestasis (HP:0001406)3.89119198
17Ketoacidosis (HP:0001993)3.85071458
18Cholecystitis (HP:0001082)3.77472767
19Abnormal gallbladder physiology (HP:0012438)3.77472767
20Deep venous thrombosis (HP:0002625)3.54524400
21Xanthomatosis (HP:0000991)3.43392517
22Abnormality of the intrinsic pathway (HP:0010989)3.33341226
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.29163588
24Symptomatic seizures (HP:0011145)3.26253250
25Neurofibrillary tangles (HP:0002185)3.20124403
26Abnormal respiratory motile cilium physiology (HP:0012261)3.11952912
27Nasal polyposis (HP:0100582)3.05618230
28Keratoconjunctivitis (HP:0001096)2.99106268
29Stomach cancer (HP:0012126)2.97445106
30Joint hemorrhage (HP:0005261)2.95533821
31Hyperlipoproteinemia (HP:0010980)2.94012822
32Cerebral inclusion bodies (HP:0100314)2.93399292
33Keratoconjunctivitis sicca (HP:0001097)2.93036843
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.89738834
35Abnormal respiratory epithelium morphology (HP:0012253)2.89309246
36Abnormal respiratory motile cilium morphology (HP:0005938)2.89309246
37Encephalitis (HP:0002383)2.87734107
38Hypochromic microcytic anemia (HP:0004840)2.85531979
39Focal motor seizures (HP:0011153)2.82409239
40Attenuation of retinal blood vessels (HP:0007843)2.81809611
41Abnormality of macrophages (HP:0004311)2.80622808
42Pheochromocytoma (HP:0002666)2.80397386
43Recurrent bacterial skin infections (HP:0005406)2.79937785
44Abnormality of T cell physiology (HP:0011840)2.76927222
45Congenital stationary night blindness (HP:0007642)2.76842663
46Recurrent fungal infections (HP:0002841)2.76057471
47Abnormal rod and cone electroretinograms (HP:0008323)2.75634433
48Late onset (HP:0003584)2.74484513
49Myokymia (HP:0002411)2.73392749
50Abnormality of the nasal mucosa (HP:0000433)2.70968072
51Recurrent abscess formation (HP:0002722)2.70965404
52Complement deficiency (HP:0004431)2.69104602
53Hypobetalipoproteinemia (HP:0003563)2.65149521
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63076312
55Chronic mucocutaneous candidiasis (HP:0002728)2.62912837
56Recurrent cutaneous fungal infections (HP:0011370)2.62912837
57Eczematoid dermatitis (HP:0000976)2.61470710
58Vacuolated lymphocytes (HP:0001922)2.60105057
59Infertility (HP:0000789)2.58739606
60Abnormality of T cells (HP:0002843)2.58717259
61Pulmonary infiltrates (HP:0002113)2.57641592
62Pancreatic cysts (HP:0001737)2.57521435
63Hemoptysis (HP:0002105)2.57023733
64Abnormal gallbladder morphology (HP:0012437)2.55939755
65Abnormal ciliary motility (HP:0012262)2.55835432
66Hyperventilation (HP:0002883)2.53488608
67Myoglobinuria (HP:0002913)2.52272624
68Hypoproteinemia (HP:0003075)2.51718596
69Epidermoid cyst (HP:0200040)2.50995842
70Epileptic encephalopathy (HP:0200134)2.48708193
71Vasculitis (HP:0002633)2.44842861
72Hypochromic anemia (HP:0001931)2.42865532
73Chronic bronchitis (HP:0004469)2.42585580
74Rhinitis (HP:0012384)2.42528644
75Hyperglycemia (HP:0003074)2.41686903
76Gout (HP:0001997)2.39950724
77Hyperammonemia (HP:0001987)2.39790353
78EEG with generalized epileptiform discharges (HP:0011198)2.39267378
79Meningitis (HP:0001287)2.38436810
80Mediastinal lymphadenopathy (HP:0100721)2.37264793
81IgG deficiency (HP:0004315)2.34899254
82Epileptiform EEG discharges (HP:0011182)2.34582222
83Recurrent skin infections (HP:0001581)2.33834723
84Hypoalphalipoproteinemia (HP:0003233)2.33717114
85Skin nodule (HP:0200036)2.33663238
86Abnormality of the common coagulation pathway (HP:0010990)2.33280545
87Hypsarrhythmia (HP:0002521)2.30482868
88Abnormality of glycolipid metabolism (HP:0010969)2.30429452
89Abnormality of liposaccharide metabolism (HP:0010968)2.30429452
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.30429452
91Neuroendocrine neoplasm (HP:0100634)2.30406607
92Abnormal drinking behavior (HP:0030082)2.29378561
93Polydipsia (HP:0001959)2.29378561
94Hypercholesterolemia (HP:0003124)2.29129646
95Hyperglycinemia (HP:0002154)2.28901590
96Pancreatic fibrosis (HP:0100732)2.27856200
97Hypolipoproteinemia (HP:0010981)2.26764385
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26339328
99Nephronophthisis (HP:0000090)2.25735903
100Panhypogammaglobulinemia (HP:0003139)2.25322546
101Supranuclear gaze palsy (HP:0000605)2.25294478
102Cholelithiasis (HP:0001081)2.23737050
103Abnormality of the renal cortex (HP:0011035)2.20620404
104Gastrointestinal infarctions (HP:0005244)2.20157283
105Severe visual impairment (HP:0001141)2.16463617
106Abnormality of the renal medulla (HP:0100957)2.15080599
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13810054
108Abolished electroretinogram (ERG) (HP:0000550)2.13687633
109Visual hallucinations (HP:0002367)2.12615363
110Keratitis (HP:0000491)2.11992030
111Conjugated hyperbilirubinemia (HP:0002908)2.11819990
112Abnormality of fatty-acid metabolism (HP:0004359)2.11389792
113Chronic obstructive pulmonary disease (HP:0006510)2.11242006
114Obstructive lung disease (HP:0006536)2.11242006
1153-Methylglutaconic aciduria (HP:0003535)2.11058331
116Abnormality of serine family amino acid metabolism (HP:0010894)2.10411686
117Abnormality of glycine metabolism (HP:0010895)2.10411686
118Abnormality of the lower motor neuron (HP:0002366)2.08481285
119Hyperglycinuria (HP:0003108)2.08139288
120Recurrent gram-negative bacterial infections (HP:0005420)2.07836071
121Status epilepticus (HP:0002133)2.07369297
122Focal seizures (HP:0007359)2.06681786
123Abnormality of T cell number (HP:0011839)2.06007032
124Pustule (HP:0200039)2.04188151
125Polyuria (HP:0000103)2.02222158
126Increased neuronal autofluorescent lipopigment (HP:0002074)2.00770888
127Severe combined immunodeficiency (HP:0004430)1.99631488
128Abnormality of midbrain morphology (HP:0002418)1.99165008
129Molar tooth sign on MRI (HP:0002419)1.99165008
130Abnormality of transition element cation homeostasis (HP:0011030)1.97986428
131Leukocytosis (HP:0001974)1.97766131
132T lymphocytopenia (HP:0005403)1.97448269
133Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96369585
134Pancreatic islet-cell hyperplasia (HP:0004510)1.95831973
135Increased cerebral lipofuscin (HP:0011813)1.95786749
136Fat malabsorption (HP:0002630)1.95466212
137Delayed CNS myelination (HP:0002188)1.95122549
138Arterial thrombosis (HP:0004420)1.94818273
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.94147331
140Generalized aminoaciduria (HP:0002909)1.93323122
141Global brain atrophy (HP:0002283)1.92885855
142Increased IgM level (HP:0003496)1.90984663
143Hemiparesis (HP:0001269)1.90367578
144Abnormality of endocrine pancreas physiology (HP:0012093)1.89857591
145Abnormality of the pancreatic islet cells (HP:0006476)1.89857591
146True hermaphroditism (HP:0010459)1.87818926
147Enlarged kidneys (HP:0000105)1.87214044
148Pulmonary embolism (HP:0002204)1.86848644
149Abnormality of the pleura (HP:0002103)1.86816801
150Abnormality of purine metabolism (HP:0004352)1.86717514
151Anorexia (HP:0002039)1.86615338
152Gangrene (HP:0100758)1.86522295
153Abnormality of the gallbladder (HP:0005264)1.86186148
154Generalized tonic-clonic seizures (HP:0002069)1.84249165
155Hyperbilirubinemia (HP:0002904)1.84219153
156Abnormality of pyrimidine metabolism (HP:0004353)1.83831918
157Type II lissencephaly (HP:0007260)1.83601153
158Cerebral hemorrhage (HP:0001342)1.83462278
159Asymmetric septal hypertrophy (HP:0001670)1.83277961
160Irritability (HP:0000737)1.82998066
161Abnormality of complement system (HP:0005339)1.82146038
162Chest pain (HP:0100749)1.81811065
163Torticollis (HP:0000473)1.80705509
164Increased serum ferritin (HP:0003281)1.80362907
165Absence seizures (HP:0002121)1.79253824
166Sensorimotor neuropathy (HP:0007141)1.78849581
167Polyneuropathy (HP:0001271)1.78681872
168Spontaneous abortion (HP:0005268)1.77433513
169Cerebral edema (HP:0002181)1.77027291
170Abnormal urine output (HP:0012590)1.76738408
171Prolonged bleeding time (HP:0003010)1.76612678
172Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75279664
173Thrombocytosis (HP:0001894)1.74799025
174Central scotoma (HP:0000603)1.74597436
175Vertigo (HP:0002321)1.74374035
176Abnormality of iron homeostasis (HP:0011031)1.74052186
177Abnormality of eosinophils (HP:0001879)1.73464558
178Decreased central vision (HP:0007663)1.73194310
179Mitochondrial inheritance (HP:0001427)1.72602696
180Episodic fever (HP:0001954)1.71473004
181Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71432177
182Parakeratosis (HP:0001036)1.70704091
183Chronic otitis media (HP:0000389)1.70468521
184Decreased circulating renin level (HP:0003351)1.70160894
185Autoimmune thrombocytopenia (HP:0001973)1.69520639
186Agitation (HP:0000713)1.69338897
187Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69040494
188Death in childhood (HP:0003819)1.68428621
189Retinal atrophy (HP:0001105)1.68314902
190Anxiety (HP:0000739)1.68294652
191Stroke (HP:0001297)1.67331121
192Tetraplegia (HP:0002445)1.67240702
193Abnormality of nucleobase metabolism (HP:0010932)1.67180863
194Insulin-resistant diabetes mellitus (HP:0000831)1.66988759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD35.03348892
2INSRR4.27210043
3PDK33.75558289
4PDK43.75558289
5TXK3.28667666
6MAP4K13.19866011
7EPHA43.10990053
8RIPK42.80133385
9TESK12.48383462
10NTRK32.44185543
11ITK2.41773659
12TNK22.38068333
13BCKDK2.25889488
14ZAP702.23497697
15FES2.22821729
16IKBKE2.21621886
17BLK2.10830435
18MAP4K22.10566290
19PDK22.08465726
20TBK12.07118575
21DAPK22.04454308
22ADRBK22.04172803
23IKBKB2.04006530
24ICK1.97937465
25TLK11.92951057
26GRK61.92201906
27IRAK41.90128754
28LMTK21.89091838
29MAPK151.86873651
30SYK1.81963530
31KIT1.77452488
32MAP3K41.74438494
33MAP3K141.66967309
34NTRK11.66093275
35MAP2K41.57088628
36JAK31.55372733
37PTK2B1.54377189
38MINK11.51680938
39CASK1.48357109
40SIK11.47307331
41BTK1.47003180
42GRK11.43271973
43MAP3K111.42551886
44TAOK31.36983284
45WNK41.36870846
46STK381.35786089
47MAP3K91.34902349
48PHKG21.34606697
49PHKG11.34606697
50MAP2K61.29945853
51CSK1.29613757
52LYN1.29330119
53TYK21.27737729
54WNK31.26428607
55DYRK1B1.23969353
56MARK11.23108888
57MATK1.22227830
58ERN11.21635600
59TEC1.18302662
60GRK71.14989768
61MAPKAPK31.14049362
62LCK1.12441621
63TRIB31.12196397
64NTRK21.09728616
65HCK1.09661030
66MAP2K71.08808277
67CAMKK11.03829028
68ACVR1B1.01733014
69DAPK11.01188312
70TESK21.00900810
71CSF1R1.00555892
72PRKCG0.97755984
73MAP2K20.96436029
74EPHA30.96262625
75IRAK10.95568691
76CDK50.95370854
77SIK20.95155242
78PAK60.94689563
79ARAF0.94618897
80TYRO30.93543235
81MAP3K20.92544871
82MAPK70.92115816
83MAP3K130.91861717
84OXSR10.90219220
85PASK0.82253119
86CHUK0.82210975
87NME10.79330052
88MARK30.78603931
89PDK10.77813941
90NUAK10.74022203
91EPHB10.73616734
92PRKCQ0.73517657
93PNCK0.73082180
94CAMK1G0.72502691
95PDPK10.72490735
96FRK0.72434337
97STK160.72023070
98PRKG20.72011394
99SGK2230.71994435
100SGK4940.71994435
101PAK30.71551742
102FER0.71217617
103CDC42BPA0.70827596
104TNIK0.70665345
105PTK60.67660412
106WNK10.67017174
107GRK50.66747059
108ZAK0.66588949
109FGFR40.65162984
110CAMK2A0.65134603
111UHMK10.64732980
112PIM10.64502356
113PIK3CG0.63641705
114JAK10.63414969
115TAOK10.62425927
116FGR0.61635820
117KSR20.60911957
118CDK180.60712810
119CAMKK20.60001295
120STK38L0.59944498
121JAK20.58381186
122MUSK0.58322041
123MAP2K30.58158494
124IRAK20.57954215
125CCNB10.57734031
126PRKCH0.57126274
127SIK30.56781296
128CDK150.56724442
129KDR0.55172720
130SGK20.55003883
131BCR0.53944894
132PRKCZ0.53300060
133MAP3K30.52705909
134PRKAA20.52554610
135KSR10.52252826
136TIE10.51759735
137BMPR1B0.51738532
138STK390.51432197
139ADRBK10.51113073
140MAP3K10.50786859
141PLK20.50014343
142BMPR20.49947645
143CDK140.49746616
144MAPK130.49581948
145PRKAA10.48592078
146PRKACG0.47644137
147CAMK2D0.47562272
148TGFBR20.46942171
149RET0.46909404
150PTK20.46618484
151CDK11A0.46426709
152RPS6KA60.46422658
153PINK10.45851672
154DYRK1A0.45023424
155CAMK10.44511357
156MAP2K10.44088670
157LATS20.40914643
158CDK190.39912899
159ABL10.37301641
160ERBB40.37047014
161CSNK1A10.35944260
162MAP3K120.35693859
163RPS6KA30.35493777
164SGK30.35322546
165MAP3K70.35034086
166PRKCE0.34903328
167MARK20.34602090
168PRKCA0.31612553
169IGF1R0.31594994
170PRKACA0.31043412
171FYN0.29774748
172STK110.29382106

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.87797776
2Allograft rejection_Homo sapiens_hsa053303.28192642
3Autoimmune thyroid disease_Homo sapiens_hsa053202.98066805
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.74869074
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.74592634
6Type I diabetes mellitus_Homo sapiens_hsa049402.71259677
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.67523321
8Asthma_Homo sapiens_hsa053102.65367126
9Staphylococcus aureus infection_Homo sapiens_hsa051502.52720363
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47748866
11Nitrogen metabolism_Homo sapiens_hsa009102.46990658
12Primary immunodeficiency_Homo sapiens_hsa053402.42444506
13Fatty acid degradation_Homo sapiens_hsa000712.41834703
14Antigen processing and presentation_Homo sapiens_hsa046122.31145290
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.31031360
16Propanoate metabolism_Homo sapiens_hsa006402.15836458
17Tryptophan metabolism_Homo sapiens_hsa003802.14276427
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08040608
19Leishmaniasis_Homo sapiens_hsa051402.05346864
20Fatty acid metabolism_Homo sapiens_hsa012122.03747010
21Arginine biosynthesis_Homo sapiens_hsa002201.95442694
22Pyruvate metabolism_Homo sapiens_hsa006201.95328292
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94696136
24Butanoate metabolism_Homo sapiens_hsa006501.93598365
25Rheumatoid arthritis_Homo sapiens_hsa053231.92951708
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87596660
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84083147
28Osteoclast differentiation_Homo sapiens_hsa043801.75711292
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75284933
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73524358
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73438366
32Synaptic vesicle cycle_Homo sapiens_hsa047211.72987716
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72613562
34PPAR signaling pathway_Homo sapiens_hsa033201.69686434
35Insulin secretion_Homo sapiens_hsa049111.66254082
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59703430
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58535127
38Hematopoietic cell lineage_Homo sapiens_hsa046401.58112024
39Sulfur metabolism_Homo sapiens_hsa009201.56469569
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51171049
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50846645
42Fatty acid biosynthesis_Homo sapiens_hsa000611.49163107
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.48549911
44Complement and coagulation cascades_Homo sapiens_hsa046101.42827090
45Bile secretion_Homo sapiens_hsa049761.39649170
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37573964
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36629344
48Histidine metabolism_Homo sapiens_hsa003401.34199450
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34099462
50Peroxisome_Homo sapiens_hsa041461.33990784
51Glucagon signaling pathway_Homo sapiens_hsa049221.32866346
52Selenocompound metabolism_Homo sapiens_hsa004501.30872287
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27488652
54Carbon metabolism_Homo sapiens_hsa012001.26774359
55Tuberculosis_Homo sapiens_hsa051521.26527641
56Phenylalanine metabolism_Homo sapiens_hsa003601.26437445
57Phototransduction_Homo sapiens_hsa047441.24778303
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23498071
59Collecting duct acid secretion_Homo sapiens_hsa049661.20684631
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20388941
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19456869
62Viral myocarditis_Homo sapiens_hsa054161.16187098
63Biosynthesis of amino acids_Homo sapiens_hsa012301.16019659
64Arachidonic acid metabolism_Homo sapiens_hsa005901.14901072
65Malaria_Homo sapiens_hsa051441.14123944
66Nicotine addiction_Homo sapiens_hsa050331.13910514
67Regulation of autophagy_Homo sapiens_hsa041401.11057367
68Amphetamine addiction_Homo sapiens_hsa050311.10191024
69T cell receptor signaling pathway_Homo sapiens_hsa046601.09717188
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09364750
71Lysosome_Homo sapiens_hsa041421.07568086
72Other glycan degradation_Homo sapiens_hsa005111.07045356
73Jak-STAT signaling pathway_Homo sapiens_hsa046301.06744689
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06237969
75Chemical carcinogenesis_Homo sapiens_hsa052041.06117627
76Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05372977
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05288130
78GABAergic synapse_Homo sapiens_hsa047271.05040684
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04539065
80Tyrosine metabolism_Homo sapiens_hsa003501.03935149
81Ether lipid metabolism_Homo sapiens_hsa005651.03174961
82Fructose and mannose metabolism_Homo sapiens_hsa000511.01550300
83Cysteine and methionine metabolism_Homo sapiens_hsa002701.00650854
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99519554
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98616697
86Vitamin B6 metabolism_Homo sapiens_hsa007500.98493824
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98036991
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97446600
89Circadian entrainment_Homo sapiens_hsa047130.96385353
90Starch and sucrose metabolism_Homo sapiens_hsa005000.95669119
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.95643316
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94933891
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94019955
94Parkinsons disease_Homo sapiens_hsa050120.89833319
95Type II diabetes mellitus_Homo sapiens_hsa049300.89348896
96ABC transporters_Homo sapiens_hsa020100.89135169
97Fatty acid elongation_Homo sapiens_hsa000620.88643322
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88089932
99African trypanosomiasis_Homo sapiens_hsa051430.87979192
100Cocaine addiction_Homo sapiens_hsa050300.85168824
101Glycerolipid metabolism_Homo sapiens_hsa005610.83446636
102Legionellosis_Homo sapiens_hsa051340.82849507
103Measles_Homo sapiens_hsa051620.82071901
104Fat digestion and absorption_Homo sapiens_hsa049750.80143028
105beta-Alanine metabolism_Homo sapiens_hsa004100.79910628
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79769432
107Herpes simplex infection_Homo sapiens_hsa051680.77596844
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77122560
109Vibrio cholerae infection_Homo sapiens_hsa051100.75560708
110Taste transduction_Homo sapiens_hsa047420.74912423
111Chemokine signaling pathway_Homo sapiens_hsa040620.74307973
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73147148
113Glutamatergic synapse_Homo sapiens_hsa047240.73034611
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72602501
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.72331822
116B cell receptor signaling pathway_Homo sapiens_hsa046620.72046035
117Dopaminergic synapse_Homo sapiens_hsa047280.71863618
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.71499605
119Pertussis_Homo sapiens_hsa051330.70805405
120Olfactory transduction_Homo sapiens_hsa047400.70530773
121Renin secretion_Homo sapiens_hsa049240.70249099
122TNF signaling pathway_Homo sapiens_hsa046680.70230409
123Toxoplasmosis_Homo sapiens_hsa051450.70051557
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69227698
125Influenza A_Homo sapiens_hsa051640.67938540
126Salivary secretion_Homo sapiens_hsa049700.67360132
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67270233
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67225794
129Cardiac muscle contraction_Homo sapiens_hsa042600.66499758
130Phagosome_Homo sapiens_hsa041450.66063259
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65704129
132Long-term potentiation_Homo sapiens_hsa047200.65138875
133Morphine addiction_Homo sapiens_hsa050320.63766184
134Retinol metabolism_Homo sapiens_hsa008300.62866159
135Steroid biosynthesis_Homo sapiens_hsa001000.62621805
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61488738
137Arginine and proline metabolism_Homo sapiens_hsa003300.56042048
138Pentose phosphate pathway_Homo sapiens_hsa000300.55961680
139RNA polymerase_Homo sapiens_hsa030200.55683754
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54872526
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.54443995
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.54347105
143Oxidative phosphorylation_Homo sapiens_hsa001900.54300392
144Ovarian steroidogenesis_Homo sapiens_hsa049130.53557773
145Galactose metabolism_Homo sapiens_hsa000520.53170360
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52910074
147Cholinergic synapse_Homo sapiens_hsa047250.52295671
148Caffeine metabolism_Homo sapiens_hsa002320.51952725
149Linoleic acid metabolism_Homo sapiens_hsa005910.51388899
150Thyroid hormone synthesis_Homo sapiens_hsa049180.51081400
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48741257
152Insulin resistance_Homo sapiens_hsa049310.44253241
153Huntingtons disease_Homo sapiens_hsa050160.44113019
154Alzheimers disease_Homo sapiens_hsa050100.42269994
155Metabolic pathways_Homo sapiens_hsa011000.40822744
156Calcium signaling pathway_Homo sapiens_hsa040200.40426984
157Lysine degradation_Homo sapiens_hsa003100.40399905
158Serotonergic synapse_Homo sapiens_hsa047260.40396171
159Platelet activation_Homo sapiens_hsa046110.40224029
160Prion diseases_Homo sapiens_hsa050200.38824707
161Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36539910
162Epstein-Barr virus infection_Homo sapiens_hsa051690.34465656
163Dorso-ventral axis formation_Homo sapiens_hsa043200.33885053
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32759669
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32680756

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