CCDC160

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.35889244
2maintenance of protein location in nucleus (GO:0051457)7.03259867
3somite rostral/caudal axis specification (GO:0032525)6.65210097
4negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.40056404
5regulation of mammary gland epithelial cell proliferation (GO:0033599)6.28665409
6regulation of response to osmotic stress (GO:0047484)6.28413268
7negative regulation of epidermis development (GO:0045683)6.16762452
8protein localization to kinetochore (GO:0034501)6.06287649
9regulation of nuclear cell cycle DNA replication (GO:0033262)5.90407079
10histone H4-K12 acetylation (GO:0043983)5.82793404
11regulation of telomere maintenance via telomerase (GO:0032210)5.80934349
12histone H4-K5 acetylation (GO:0043981)5.75863387
13histone H4-K8 acetylation (GO:0043982)5.75863387
14negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.74319747
15negative regulation of cell cycle G2/M phase transition (GO:1902750)5.69992963
16muscle organ morphogenesis (GO:0048644)5.63833969
17negative regulation of telomerase activity (GO:0051974)5.40574991
18regulation of MHC class I biosynthetic process (GO:0045343)5.34683969
19regulation of cilium movement (GO:0003352)5.27709028
20rRNA transcription (GO:0009303)5.23109508
21notochord development (GO:0030903)5.06427916
22mitotic sister chromatid segregation (GO:0000070)4.94347240
23phenol-containing compound catabolic process (GO:0019336)4.89695882
24negative regulation of epidermal cell differentiation (GO:0045605)4.80609977
25heterochromatin organization (GO:0070828)4.74408649
26cytidine deamination (GO:0009972)4.71557608
27cytidine metabolic process (GO:0046087)4.71557608
28cytidine catabolic process (GO:0006216)4.71557608
29rRNA methylation (GO:0031167)4.59637409
30response to dietary excess (GO:0002021)4.57293729
31DNA replication-dependent nucleosome assembly (GO:0006335)4.53713208
32DNA replication-dependent nucleosome organization (GO:0034723)4.53713208
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.45158571
34hormone catabolic process (GO:0042447)4.44758946
35coenzyme catabolic process (GO:0009109)4.41435746
36intraciliary transport (GO:0042073)4.40689832
37protein localization to chromosome, centromeric region (GO:0071459)4.38643179
38quinone metabolic process (GO:1901661)4.35775651
39epithelial cilium movement (GO:0003351)4.33087302
40positive regulation of DNA-dependent DNA replication (GO:2000105)4.24885216
41rRNA modification (GO:0000154)4.24303781
42nucleoside transmembrane transport (GO:1901642)4.22993418
43primitive streak formation (GO:0090009)4.22388158
44cell fate commitment involved in formation of primary germ layer (GO:0060795)4.20665310
45histone H4-K16 acetylation (GO:0043984)4.18674087
46branching involved in mammary gland duct morphogenesis (GO:0060444)4.17964323
47negative regulation of telomere maintenance (GO:0032205)4.16834264
48regulation of translation in response to stress (GO:0043555)4.14562165
49chromatin assembly (GO:0031497)4.09633324
50nuclear pore complex assembly (GO:0051292)4.05693649
51DNA double-strand break processing (GO:0000729)4.05212331
52cullin deneddylation (GO:0010388)4.05007069
53regulation of apoptotic process involved in morphogenesis (GO:1902337)4.04874775
54sister chromatid segregation (GO:0000819)4.04485303
55DNA replication checkpoint (GO:0000076)4.03219139
56cilium movement (GO:0003341)3.91493514
57maintenance of protein localization in organelle (GO:0072595)3.85162942
58chromatin remodeling at centromere (GO:0031055)3.79678784
59interferon-gamma production (GO:0032609)3.77359549
60pattern specification involved in kidney development (GO:0061004)3.76550284
61cardiovascular system development (GO:0072358)3.73871833
62axonemal dynein complex assembly (GO:0070286)3.73425981
63intestinal epithelial cell development (GO:0060576)3.70910196
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.66048007
65pre-miRNA processing (GO:0031054)3.65454622
66microtubule severing (GO:0051013)3.64805041
67regulation of posttranscriptional gene silencing (GO:0060147)3.64321052
68regulation of gene silencing by miRNA (GO:0060964)3.64321052
69regulation of gene silencing by RNA (GO:0060966)3.64321052
70nuclear pore organization (GO:0006999)3.63433770
71protein polyglutamylation (GO:0018095)3.62075948
72tachykinin receptor signaling pathway (GO:0007217)3.61175859
73regulation of microtubule-based movement (GO:0060632)3.59982041
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.57409273
75proline transport (GO:0015824)3.56477121
76icosanoid secretion (GO:0032309)3.52458616
77arachidonic acid secretion (GO:0050482)3.52458616
78protein deneddylation (GO:0000338)3.50878412
79intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.49308383
80mitochondrion distribution (GO:0048311)3.48823453
81CENP-A containing nucleosome assembly (GO:0034080)3.48806373
82cellular modified amino acid catabolic process (GO:0042219)3.47542458
83DNA damage response, detection of DNA damage (GO:0042769)3.46543951
84regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.46206516
85chaperone-mediated protein transport (GO:0072321)3.41886142
86ventricular system development (GO:0021591)3.41650841
87regulation of telomere maintenance (GO:0032204)3.41184502
88bone trabecula formation (GO:0060346)3.35583005
89regulation of telomerase activity (GO:0051972)3.32627889
90nonmotile primary cilium assembly (GO:0035058)3.30171317
91epoxygenase P450 pathway (GO:0019373)3.29758111
92detection of temperature stimulus (GO:0016048)3.28364043
93cilium or flagellum-dependent cell motility (GO:0001539)3.28195119
94limb bud formation (GO:0060174)3.28049990
95protein neddylation (GO:0045116)3.26995403
96GDP-mannose metabolic process (GO:0019673)3.25651756
97regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.25593444
98pyrimidine ribonucleoside catabolic process (GO:0046133)3.22068559
99ribosome biogenesis (GO:0042254)3.21833965
100anterior/posterior axis specification (GO:0009948)3.21564891
101replication fork processing (GO:0031297)3.21134834
102intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.20628812
103behavioral response to nicotine (GO:0035095)3.20328722
104somite development (GO:0061053)3.19812287
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18474769
106vitamin A metabolic process (GO:0006776)3.18027730
107negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.17423249
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16723240
109presynaptic membrane assembly (GO:0097105)3.13378377
110nucleoside transport (GO:0015858)3.10797241
111retinoic acid receptor signaling pathway (GO:0048384)3.09226745
112trophectodermal cell differentiation (GO:0001829)3.09154422
113mRNA stabilization (GO:0048255)3.07632005
114RNA stabilization (GO:0043489)3.07632005
115histone exchange (GO:0043486)3.07398272
116signal transduction involved in regulation of gene expression (GO:0023019)3.06440834
117cilium morphogenesis (GO:0060271)3.05612317
118embryonic axis specification (GO:0000578)3.05492244
119protein complex biogenesis (GO:0070271)3.05472866
120thyroid hormone generation (GO:0006590)3.05149366
121cilium organization (GO:0044782)3.04760549
122positive regulation of protein deacetylation (GO:0090312)3.04083607
123water-soluble vitamin biosynthetic process (GO:0042364)3.02866948
124cilium assembly (GO:0042384)3.02135814
125segment specification (GO:0007379)3.00554135
126proteasome assembly (GO:0043248)2.99322247
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.95487055
128NADH dehydrogenase complex assembly (GO:0010257)2.95487055
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95487055
130mitochondrial respiratory chain complex assembly (GO:0033108)2.93938806
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92474087
132kinetochore assembly (GO:0051382)2.91193284
133axoneme assembly (GO:0035082)2.90463376
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89809337
135DNA replication-independent nucleosome organization (GO:0034724)2.89601904
136DNA replication-independent nucleosome assembly (GO:0006336)2.89601904
137olfactory bulb development (GO:0021772)2.86998185
138protein localization to cilium (GO:0061512)2.83367337
139respiratory chain complex IV assembly (GO:0008535)2.82332489
140presynaptic membrane organization (GO:0097090)2.78186246
141platelet dense granule organization (GO:0060155)2.70580364
142protein-cofactor linkage (GO:0018065)2.70382088
143sequestering of actin monomers (GO:0042989)2.69883788
144resolution of meiotic recombination intermediates (GO:0000712)2.68826298
145kinetochore organization (GO:0051383)2.67756058
146retinal ganglion cell axon guidance (GO:0031290)2.65604871
147left/right pattern formation (GO:0060972)2.64367044
148neuron fate determination (GO:0048664)2.64252081
149neural tube formation (GO:0001841)2.62888691
150base-excision repair, AP site formation (GO:0006285)2.62267922
151energy coupled proton transport, down electrochemical gradient (GO:0015985)2.58256742
152ATP synthesis coupled proton transport (GO:0015986)2.58256742
153otic vesicle formation (GO:0030916)2.57211637
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56423528
155centriole replication (GO:0007099)2.56007151
156DNA ligation (GO:0006266)2.54967278
157cell proliferation in forebrain (GO:0021846)2.54882335
158cytochrome complex assembly (GO:0017004)2.54438219
159limb development (GO:0060173)2.52307582
160appendage development (GO:0048736)2.52307582
161recombinational repair (GO:0000725)2.51702652
162pyrimidine nucleobase catabolic process (GO:0006208)2.50416352
163negative regulation of DNA-dependent DNA replication (GO:2000104)2.50225034
164double-strand break repair via homologous recombination (GO:0000724)2.48885419
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.44885305
166detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44697753
167inner mitochondrial membrane organization (GO:0007007)2.42344708
168smoothened signaling pathway (GO:0007224)2.42040416
169response to pheromone (GO:0019236)2.41038462
170negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40478379
171RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39001809
172tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39001809
173female gonad development (GO:0008585)2.37510592
174regulation of non-canonical Wnt signaling pathway (GO:2000050)2.37101162
175regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.36383910
176photoreceptor cell maintenance (GO:0045494)2.35172033
177determination of left/right symmetry (GO:0007368)2.34439392
178regulation of helicase activity (GO:0051095)2.33549717
179positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.33320672
180reciprocal DNA recombination (GO:0035825)2.33247096
181reciprocal meiotic recombination (GO:0007131)2.33247096
182anterograde synaptic vesicle transport (GO:0048490)2.31750302
183double-strand break repair via nonhomologous end joining (GO:0006303)2.30511135
184non-recombinational repair (GO:0000726)2.30511135
185ncRNA catabolic process (GO:0034661)2.29422345
186cellular component assembly involved in morphogenesis (GO:0010927)2.29299607
187regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.28426343
188regulation of mitotic spindle checkpoint (GO:1903504)2.28426343
189negative regulation of DNA recombination (GO:0045910)2.27837106
190behavioral response to ethanol (GO:0048149)2.26964896
191histone H2A acetylation (GO:0043968)2.26584009
192daunorubicin metabolic process (GO:0044597)11.0872553
193polyketide metabolic process (GO:0030638)11.0872553
194doxorubicin metabolic process (GO:0044598)11.0872553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.93860620
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.93860620
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.93860620
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.12386338
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.15172390
6E2F7_22180533_ChIP-Seq_HELA_Human3.90913667
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.74679334
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.60188898
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.14685285
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.11963887
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.09575822
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.05289420
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.02392680
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.84994881
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.84579246
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.75088012
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.73840903
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.67063000
19ZNF274_21170338_ChIP-Seq_K562_Hela2.64210078
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61623904
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55534693
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47346459
23VDR_22108803_ChIP-Seq_LS180_Human2.46208815
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42326819
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.39357598
26IGF1R_20145208_ChIP-Seq_DFB_Human2.36486068
27FUS_26573619_Chip-Seq_HEK293_Human2.35148473
28EWS_26573619_Chip-Seq_HEK293_Human2.31080422
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27189491
30NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.26960673
31ELK1_19687146_ChIP-ChIP_HELA_Human2.21588538
32NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.17563979
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14520154
34POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05152731
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04775086
36EZH2_22144423_ChIP-Seq_EOC_Human2.03260820
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96869670
38IRF1_19129219_ChIP-ChIP_H3396_Human1.95958167
39GBX2_23144817_ChIP-Seq_PC3_Human1.94111060
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.93420845
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92377987
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.92120762
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92020963
44P300_19829295_ChIP-Seq_ESCs_Human1.92002567
45TAF15_26573619_Chip-Seq_HEK293_Human1.90537504
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87636921
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.84658914
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84358647
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82086312
50POU5F1_16518401_ChIP-PET_MESCs_Mouse1.80499417
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77298633
52TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.74951476
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74391939
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73467213
55MYC_18940864_ChIP-ChIP_HL60_Human1.71317095
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70501498
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68102148
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68030522
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65344654
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64988424
61NANOG_18692474_ChIP-Seq_MEFs_Mouse1.63238849
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.63059930
63NANOG_18692474_ChIP-Seq_MESCs_Mouse1.60683167
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57403673
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55929811
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54452627
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49663402
68POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.48885323
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.48305696
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47892535
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47782751
72E2F1_17053090_ChIP-ChIP_MCF-7_Human1.46244713
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45111306
74* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45049924
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43470906
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.42993170
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41705291
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.40633521
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40543272
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39295525
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39091036
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39063206
83VDR_23849224_ChIP-Seq_CD4+_Human1.38718392
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.38048608
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37302649
86SOX2_18692474_ChIP-Seq_MESCs_Mouse1.37137366
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.35803324
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32026242
89NANOG_16518401_ChIP-PET_MESCs_Mouse1.31136973
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30514449
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28886726
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28886726
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27827629
94BCAT_22108803_ChIP-Seq_LS180_Human1.27241980
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26796798
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26077008
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25017103
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22930177
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22299142
100CBP_20019798_ChIP-Seq_JUKART_Human1.22208906
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22208906
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21900035
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19184059
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19136332
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18915588
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.18124447
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17818024
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17751883
109SMAD4_21799915_ChIP-Seq_A2780_Human1.17685494
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.15733243
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15688669
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13915212
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13654787
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13484726
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12081023
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.11503648
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10687104
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.10153251
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.09502700
120* TCF4_22108803_ChIP-Seq_LS180_Human1.09449350
121POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09340675
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07701811
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07168836
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06757633
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06399925
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06035581
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05971711
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05479095
129ER_23166858_ChIP-Seq_MCF-7_Human1.05389143
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03002392
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02888135
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02535680
133TP53_22573176_ChIP-Seq_HFKS_Human1.01079552
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00521114
135TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99853506
136RUNX2_22187159_ChIP-Seq_PCA_Human0.99257549
137TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98983070
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97857953
139NFE2_27457419_Chip-Seq_LIVER_Mouse0.97737296
140AR_25329375_ChIP-Seq_VCAP_Human0.96458208
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96321992
142STAT3_23295773_ChIP-Seq_U87_Human0.95760838
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95712772
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95708557
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.95522894
146SOX2_19829295_ChIP-Seq_ESCs_Human0.95255795
147NANOG_19829295_ChIP-Seq_ESCs_Human0.95255795
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95069566
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94587546
150TTF2_22483619_ChIP-Seq_HELA_Human0.94201416
151EST1_17652178_ChIP-ChIP_JURKAT_Human0.89661348
152TP53_22127205_ChIP-Seq_IMR90_Human0.87299410
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.86907581
154STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86360624
155RNF2_27304074_Chip-Seq_NSC_Mouse0.85887674
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84876267
157RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83399540
158E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82002315
159KAP1_27257070_Chip-Seq_ESCs_Mouse0.81860035
160NOTCH1_21737748_ChIP-Seq_TLL_Human0.79735947
161TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79489259
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79066192
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78064466
164ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76739100
165NCOR1_26117541_ChIP-Seq_K562_Human0.75303533
166SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.73366177
167ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73037834
168KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72982085
169MYC_22102868_ChIP-Seq_BL_Human0.70728605
170YY1_22570637_ChIP-Seq_MALME-3M_Human0.68717317
171CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.68072359
172EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.67311423
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67150914
174WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.66384964
175RING1B_27294783_Chip-Seq_NPCs_Mouse0.66116979
176SMC4_20622854_ChIP-Seq_HELA_Human0.65610479
177ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.64884396
178GATA1_26923725_Chip-Seq_HPCs_Mouse0.64560878
179FOXP3_21729870_ChIP-Seq_TREG_Human0.63069151
180SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.62211283
181SOX3_22085726_ChIP-Seq_NPCs_Mouse0.62177215
182SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.61353912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.33747373
2MP0006292_abnormal_olfactory_placode4.30577045
3MP0003011_delayed_dark_adaptation4.22638913
4MP0002254_reproductive_system_inflammat3.74419937
5MP0003122_maternal_imprinting3.71778649
6MP0003890_abnormal_embryonic-extraembry3.71722812
7MP0005499_abnormal_olfactory_system3.59436075
8MP0005394_taste/olfaction_phenotype3.59436075
9MP0004858_abnormal_nervous_system3.49391959
10MP0008057_abnormal_DNA_replication3.01764911
11MP0005075_abnormal_melanosome_morpholog2.91174435
12MP0002653_abnormal_ependyma_morphology2.86844321
13MP0002332_abnormal_exercise_endurance2.83351712
14MP0004957_abnormal_blastocyst_morpholog2.80729891
15MP0003136_yellow_coat_color2.79981154
16MP0003121_genomic_imprinting2.75327355
17MP0002938_white_spotting2.74072888
18MP0002102_abnormal_ear_morphology2.53267805
19MP0006035_abnormal_mitochondrial_morpho2.36254590
20MP0003880_abnormal_central_pattern2.33698308
21MP0005257_abnormal_intraocular_pressure2.22261807
22MP0001984_abnormal_olfaction2.21524236
23MP0000566_synostosis2.15484020
24MP0000678_abnormal_parathyroid_gland2.12048757
25MP0001529_abnormal_vocalization2.03671113
26MP0008877_abnormal_DNA_methylation2.00041740
27MP0003123_paternal_imprinting1.97928880
28MP0008058_abnormal_DNA_repair1.95363910
29MP0003938_abnormal_ear_development1.93950259
30MP0003705_abnormal_hypodermis_morpholog1.92245576
31MP0000778_abnormal_nervous_system1.89195689
32MP0010352_gastrointestinal_tract_polyps1.87085786
33MP0006072_abnormal_retinal_apoptosis1.80510232
34MP0001672_abnormal_embryogenesis/_devel1.78840368
35MP0005380_embryogenesis_phenotype1.78840368
36MP0010030_abnormal_orbit_morphology1.69324782
37MP0002277_abnormal_respiratory_mucosa1.68557381
38MP0002127_abnormal_cardiovascular_syste1.68312509
39MP0004043_abnormal_pH_regulation1.66209056
40MP0002088_abnormal_embryonic_growth/wei1.65279362
41MP0000631_abnormal_neuroendocrine_gland1.64779373
42MP0001293_anophthalmia1.64721711
43MP0003984_embryonic_growth_retardation1.63331591
44MP0002234_abnormal_pharynx_morphology1.63161785
45MP0008789_abnormal_olfactory_epithelium1.52676107
46MP0008961_abnormal_basal_metabolism1.50935598
47MP0001849_ear_inflammation1.50166548
48MP0002932_abnormal_joint_morphology1.47040854
49MP0003183_abnormal_peptide_metabolism1.46994274
50MP0003878_abnormal_ear_physiology1.44928227
51MP0005377_hearing/vestibular/ear_phenot1.44928227
52MP0000372_irregular_coat_pigmentation1.44799137
53MP0001486_abnormal_startle_reflex1.42819906
54MP0000762_abnormal_tongue_morphology1.42003629
55MP0005551_abnormal_eye_electrophysiolog1.41302325
56MP0003283_abnormal_digestive_organ1.40768377
57MP0004133_heterotaxia1.39265083
58MP0005171_absent_coat_pigmentation1.38112518
59MP0000049_abnormal_middle_ear1.38060012
60MP0002092_abnormal_eye_morphology1.36880474
61MP0000350_abnormal_cell_proliferation1.36114895
62MP0003315_abnormal_perineum_morphology1.35473648
63MP0003119_abnormal_digestive_system1.33068851
64MP0001346_abnormal_lacrimal_gland1.32901836
65MP0002233_abnormal_nose_morphology1.31016029
66MP0005266_abnormal_metabolism1.29124372
67MP0002736_abnormal_nociception_after1.27908757
68MP0001348_abnormal_lacrimal_gland1.24883400
69* MP0002085_abnormal_embryonic_tissue1.24652976
70MP0003077_abnormal_cell_cycle1.22273002
71MP0002638_abnormal_pupillary_reflex1.17961286
72MP0002697_abnormal_eye_size1.17643600
73MP0002114_abnormal_axial_skeleton1.16358037
74MP0003941_abnormal_skin_development1.16325563
75MP0003718_maternal_effect1.16264612
76MP0003787_abnormal_imprinting1.15937556
77MP0002282_abnormal_trachea_morphology1.15792814
78MP0000026_abnormal_inner_ear1.15716245
79MP0001485_abnormal_pinna_reflex1.15595190
80MP0000647_abnormal_sebaceous_gland1.13757868
81* MP0002086_abnormal_extraembryonic_tissu1.11102874
82MP0006082_CNS_inflammation1.08192413
83MP0006276_abnormal_autonomic_nervous1.08082456
84MP0009046_muscle_twitch1.07889160
85MP0000383_abnormal_hair_follicle1.07636864
86MP0002837_dystrophic_cardiac_calcinosis1.06585489
87MP0003755_abnormal_palate_morphology1.06173049
88MP0005195_abnormal_posterior_eye1.06157404
89MP0000428_abnormal_craniofacial_morphol1.06022711
90MP0009379_abnormal_foot_pigmentation1.05695948
91* MP0002084_abnormal_developmental_patter1.04608577
92MP0003567_abnormal_fetal_cardiomyocyte1.04316327
93MP0001324_abnormal_eye_pigmentation1.03439359
94MP0002751_abnormal_autonomic_nervous1.03366559
95MP0000432_abnormal_head_morphology1.01770474
96MP0004147_increased_porphyrin_level0.99430716
97MP0002557_abnormal_social/conspecific_i0.98489673
98MP0001968_abnormal_touch/_nociception0.96368228
99MP0004197_abnormal_fetal_growth/weight/0.96328852
100MP0003137_abnormal_impulse_conducting0.95951586
101MP0003111_abnormal_nucleus_morphology0.95735165
102MP0003935_abnormal_craniofacial_develop0.95675563
103MP0008932_abnormal_embryonic_tissue0.95532024
104MP0001299_abnormal_eye_distance/0.95276574
105MP0005367_renal/urinary_system_phenotyp0.93686500
106MP0000516_abnormal_urinary_system0.93686500
107MP0005391_vision/eye_phenotype0.92676025
108MP0005646_abnormal_pituitary_gland0.91791066
109MP0005408_hypopigmentation0.91624861
110MP0000427_abnormal_hair_cycle0.91337716
111MP0009745_abnormal_behavioral_response0.90430503
112MP0005623_abnormal_meninges_morphology0.89566742
113MP0002970_abnormal_white_adipose0.89507868
114MP0002111_abnormal_tail_morphology0.89343552
115MP0008770_decreased_survivor_rate0.89313700
116MP0001730_embryonic_growth_arrest0.88727571
117MP0005248_abnormal_Harderian_gland0.88569868
118MP0003693_abnormal_embryo_hatching0.85702895
119MP0001697_abnormal_embryo_size0.84405603
120MP0002210_abnormal_sex_determination0.84365692
121MP0010094_abnormal_chromosome_stability0.83251500
122MP0002272_abnormal_nervous_system0.82451034
123MP0002184_abnormal_innervation0.82396634
124MP0003937_abnormal_limbs/digits/tail_de0.82046006
125MP0002152_abnormal_brain_morphology0.81823473
126MP0009703_decreased_birth_body0.81284829
127MP0001963_abnormal_hearing_physiology0.81157498
128MP0000653_abnormal_sex_gland0.79422872
129MP0008875_abnormal_xenobiotic_pharmacok0.79233559
130MP0003385_abnormal_body_wall0.77947367
131MP0001929_abnormal_gametogenesis0.77766324
132MP0002080_prenatal_lethality0.77498955
133MP0005508_abnormal_skeleton_morphology0.77398732
134MP0009697_abnormal_copulation0.76814189
135MP0002116_abnormal_craniofacial_bone0.76722105
136MP0000313_abnormal_cell_death0.75788899
137MP0001286_abnormal_eye_development0.72901424
138MP0002269_muscular_atrophy0.71143660
139MP0004381_abnormal_hair_follicle0.68087930
140MP0002081_perinatal_lethality0.67389255
141* MP0003861_abnormal_nervous_system0.66989337
142MP0000750_abnormal_muscle_regeneration0.65555176
143MP0000358_abnormal_cell_content/0.64870826
144MP0002249_abnormal_larynx_morphology0.63428098
145* MP0002925_abnormal_cardiovascular_devel0.62666906
146MP0000749_muscle_degeneration0.62007166
147MP0008872_abnormal_physiological_respon0.61665738
148MP0002752_abnormal_somatic_nervous0.60189779
149MP0004883_abnormal_blood_vessel0.59576950
150MP0003786_premature_aging0.59381251
151MP0004272_abnormal_basement_membrane0.59327165
152MP0006036_abnormal_mitochondrial_physio0.58442572
153MP0005253_abnormal_eye_physiology0.58180953
154MP0005410_abnormal_fertilization0.56695477
155MP0002909_abnormal_adrenal_gland0.55713334
156MP0000955_abnormal_spinal_cord0.55247183
157MP0002396_abnormal_hematopoietic_system0.55210740
158MP0004142_abnormal_muscle_tone0.54595524
159MP0001145_abnormal_male_reproductive0.54546358

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.65559271
2Hypochromic microcytic anemia (HP:0004840)5.84341889
3Hepatoblastoma (HP:0002884)5.36697711
4Abnormality of the lower motor neuron (HP:0002366)5.08303652
5Multiple enchondromatosis (HP:0005701)4.89717507
6Rib fusion (HP:0000902)4.78618864
7Ependymoma (HP:0002888)4.49106709
8Pancreatic fibrosis (HP:0100732)3.81299426
9Neoplasm of striated muscle (HP:0009728)3.78660666
10Nephroblastoma (Wilms tumor) (HP:0002667)3.72531695
11True hermaphroditism (HP:0010459)3.69690398
12Rectal fistula (HP:0100590)3.67231999
13Rectovaginal fistula (HP:0000143)3.67231999
14Bifid tongue (HP:0010297)3.60782871
15Molar tooth sign on MRI (HP:0002419)3.60346265
16Abnormality of midbrain morphology (HP:0002418)3.60346265
17Rhabdomyosarcoma (HP:0002859)3.59202225
18Pancreatic cysts (HP:0001737)3.55845064
19Embryonal renal neoplasm (HP:0011794)3.46534492
20Partial duplication of thumb phalanx (HP:0009944)3.38792529
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37764320
22Fused cervical vertebrae (HP:0002949)3.37154338
23Hypoplasia of the fovea (HP:0007750)3.34469575
24Aplasia/Hypoplasia of the fovea (HP:0008060)3.34469575
25Nephronophthisis (HP:0000090)3.33436884
26Abnormality of the labia minora (HP:0012880)3.31287757
27Testicular atrophy (HP:0000029)3.28281315
28Septo-optic dysplasia (HP:0100842)3.23611920
29Medial flaring of the eyebrow (HP:0010747)3.23289232
30Intestinal fistula (HP:0100819)3.22565606
31Amyotrophic lateral sclerosis (HP:0007354)3.20115493
32Abnormality of the astrocytes (HP:0100707)3.19081496
33Astrocytoma (HP:0009592)3.19081496
34Aplasia/hypoplasia of the humerus (HP:0006507)3.18333106
35Abnormality of the salivary glands (HP:0010286)3.15038925
36Vaginal fistula (HP:0004320)3.14376609
37Colon cancer (HP:0003003)3.13705697
38Short humerus (HP:0005792)3.10839741
39Abnormal ciliary motility (HP:0012262)3.03031793
40Hyperinsulinemic hypoglycemia (HP:0000825)3.01872982
41Anomalous pulmonary venous return (HP:0010772)3.01678981
42Abnormal respiratory motile cilium physiology (HP:0012261)2.98845321
43Abnormal lung lobation (HP:0002101)2.95969231
44Partial duplication of the phalanx of hand (HP:0009999)2.94868985
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.91033621
46Ragged-red muscle fibers (HP:0003200)2.90867180
47Gait imbalance (HP:0002141)2.90861819
48Abnormal respiratory epithelium morphology (HP:0012253)2.89213437
49Abnormal respiratory motile cilium morphology (HP:0005938)2.89213437
50Congenital primary aphakia (HP:0007707)2.88536164
51Horizontal nystagmus (HP:0000666)2.85679973
52Chromsome breakage (HP:0040012)2.81781373
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.77212328
54Genital tract atresia (HP:0001827)2.73392512
55Abnormality of the renal medulla (HP:0100957)2.70850276
56Generalized hypotonia (HP:0001290)2.69398874
57Vaginal atresia (HP:0000148)2.67762290
58Nephrogenic diabetes insipidus (HP:0009806)2.66446033
59Chronic hepatic failure (HP:0100626)2.65929315
60Shawl scrotum (HP:0000049)2.65303457
61Trismus (HP:0000211)2.63272164
62Acute necrotizing encephalopathy (HP:0006965)2.62252061
63Anophthalmia (HP:0000528)2.61575370
64Abnormality of the pulmonary veins (HP:0011718)2.57456687
65Intestinal atresia (HP:0011100)2.57370459
66Rhinitis (HP:0012384)2.57231989
67Hyperglycinemia (HP:0002154)2.56642922
68Oligodactyly (hands) (HP:0001180)2.55409074
69Postaxial foot polydactyly (HP:0001830)2.54491337
70Abnormal cartilage morphology (HP:0002763)2.53672029
71Abnormality of the fovea (HP:0000493)2.52855514
72Sensory axonal neuropathy (HP:0003390)2.51399695
73Sclerocornea (HP:0000647)2.50791183
74Periauricular skin pits (HP:0100277)2.49661857
75Preauricular pit (HP:0004467)2.49661857
76Supernumerary spleens (HP:0009799)2.48128019
77Hyperventilation (HP:0002883)2.47699425
78Postaxial hand polydactyly (HP:0001162)2.46399572
79Anencephaly (HP:0002323)2.43514431
80Abnormality of abdominal situs (HP:0011620)2.42539780
81Abdominal situs inversus (HP:0003363)2.42539780
82Preauricular skin tag (HP:0000384)2.41314127
83Occipital encephalocele (HP:0002085)2.41171421
84Tongue fasciculations (HP:0001308)2.40833385
85Acute encephalopathy (HP:0006846)2.40748903
86Impulsivity (HP:0100710)2.40711342
87Glioma (HP:0009733)2.40576240
88Cystic liver disease (HP:0006706)2.39267225
89Abnormality of the phalanges of the hallux (HP:0010057)2.38648676
90Preaxial hand polydactyly (HP:0001177)2.38345687
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.37875436
92Absent/shortened dynein arms (HP:0200106)2.37875436
93Volvulus (HP:0002580)2.37017541
94Large earlobe (HP:0009748)2.35425334
95Abnormality of chromosome segregation (HP:0002916)2.33619869
96Abnormality of the musculature of the hand (HP:0001421)2.33191421
97Tetraplegia (HP:0002445)2.32768424
98Optic nerve hypoplasia (HP:0000609)2.30786714
99Mitochondrial inheritance (HP:0001427)2.27836051
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.27548108
101Oligodactyly (HP:0012165)2.27249268
102Stenosis of the external auditory canal (HP:0000402)2.26440128
103Neoplasm of the heart (HP:0100544)2.23796669
104Nasolacrimal duct obstruction (HP:0000579)2.23069475
105Reduced antithrombin III activity (HP:0001976)2.22822365
106Meckel diverticulum (HP:0002245)2.22417703
107Hypopigmentation of the fundus (HP:0007894)2.22264017
108Aplasia/Hypoplasia of the macula (HP:0008059)2.21805775
109Pendular nystagmus (HP:0012043)2.21001093
110Progressive muscle weakness (HP:0003323)2.20561151
111Renal hypoplasia (HP:0000089)2.18831799
112Absent septum pellucidum (HP:0001331)2.18327084
113Abnormal mitochondria in muscle tissue (HP:0008316)2.17321128
114Progressive macrocephaly (HP:0004481)2.17053426
115Muscle fibrillation (HP:0010546)2.16958930
116Aplasia/Hypoplasia of the uvula (HP:0010293)2.16915640
117Increased CSF lactate (HP:0002490)2.15555598
118Abnormality of the pubic bones (HP:0003172)2.15488831
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14714657
120Short 5th finger (HP:0009237)2.13080737
121Hypochromic anemia (HP:0001931)2.12197134
122Malignant neoplasm of the central nervous system (HP:0100836)2.10735339
123Skin tags (HP:0010609)2.10130109
124Hand muscle atrophy (HP:0009130)2.09167014
125Hepatocellular necrosis (HP:0001404)2.08992246
126Aplasia/Hypoplasia of the sternum (HP:0006714)2.08773034
127Poor coordination (HP:0002370)2.08054518
128Abnormality of the ileum (HP:0001549)2.07232288
129Premature ovarian failure (HP:0008209)2.07167515
130Atrophy/Degeneration involving motor neurons (HP:0007373)2.06110304
131Abnormality of the distal phalanx of the thumb (HP:0009617)2.05990834
132Increased serum pyruvate (HP:0003542)2.04080153
133Abnormality of glycolysis (HP:0004366)2.04080153
134Difficulty running (HP:0009046)2.04073904
135Abnormality of small intestinal villus morphology (HP:0011472)2.02831249
136Villous atrophy (HP:0011473)2.02831249
137Gastrointestinal atresia (HP:0002589)2.02356902
138Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01911849
139Amblyopia (HP:0000646)2.01378131
140Renal duplication (HP:0000075)2.01239274
1413-Methylglutaconic aciduria (HP:0003535)2.00833030
142Resting tremor (HP:0002322)2.00783362
143Pseudobulbar signs (HP:0002200)2.00543510
144Increased hepatocellular lipid droplets (HP:0006565)2.00039334
145Progressive external ophthalmoplegia (HP:0000590)1.99849529
146Facial cleft (HP:0002006)1.99702537
147Upper motor neuron abnormality (HP:0002127)1.99192021
148Skin pits (HP:0100276)1.98566264
149Triphalangeal thumb (HP:0001199)1.98161199
150Labial hypoplasia (HP:0000066)1.97929172
151Congenital hepatic fibrosis (HP:0002612)1.97853434
152Glossoptosis (HP:0000162)1.97466870
153Median cleft lip (HP:0000161)1.96052528
154Vertebral fusion (HP:0002948)1.94846489
155Narrow forehead (HP:0000341)1.93743203
156Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93677332
157Upper limb muscle weakness (HP:0003484)1.93451480
158Increased connective tissue (HP:0009025)1.93189914
159Microvesicular hepatic steatosis (HP:0001414)1.92018558
160Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91351470
161Hemivertebrae (HP:0002937)1.91180630
162Broad foot (HP:0001769)1.91102932
163Fasciculations (HP:0002380)1.91102761
164Chorioretinal coloboma (HP:0000567)1.90410124
165Dandy-Walker malformation (HP:0001305)1.90252574
166Hypoplastic female external genitalia (HP:0012815)1.88922767
167Male pseudohermaphroditism (HP:0000037)1.88442784
168Decreased testicular size (HP:0008734)1.84095853
169Aganglionic megacolon (HP:0002251)1.83634299
170Ectopic kidney (HP:0000086)1.83156384
171Esophageal atresia (HP:0002032)1.83067226
172Short tibia (HP:0005736)1.82263815
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.81004958
174Growth hormone deficiency (HP:0000824)1.79568542
175Hyperglycinuria (HP:0003108)1.78308913
176Lipid accumulation in hepatocytes (HP:0006561)1.77257882
177Abnormality of the septum pellucidum (HP:0007375)1.76780225
178Bile duct proliferation (HP:0001408)1.76490623
179Abnormal biliary tract physiology (HP:0012439)1.76490623
180Abnormal number of erythroid precursors (HP:0012131)1.75628351
181Hypoplastic pelvis (HP:0008839)1.75423781
182Cerebral edema (HP:0002181)1.75322958
183Chronic bronchitis (HP:0004469)1.73971007
184Aplasia/Hypoplasia of the spleen (HP:0010451)1.73199398
185Hepatic necrosis (HP:0002605)1.72238982
186Abnormality of serine family amino acid metabolism (HP:0010894)1.70362320
187Abnormality of glycine metabolism (HP:0010895)1.70362320
188Tubulointerstitial nephritis (HP:0001970)1.66064138
189Abnormality of the renal cortex (HP:0011035)1.65890433
190Holoprosencephaly (HP:0001360)1.65666815
191Tubular atrophy (HP:0000092)1.65095342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.40144221
2GRK55.75490267
3GRK64.43659344
4ERN14.05926717
5ADRBK23.53965516
6GRK13.40062557
7TYRO32.79999763
8BMPR1B2.72650882
9CSF1R2.61759612
10TTK2.60796173
11EPHA42.54185950
12GRK72.52537658
13TNIK2.43911259
14MAP4K22.39615838
15TRIM282.30059818
16TGFBR22.29674006
17BCR2.28467807
18WNK12.22181619
19MAPK72.19455333
20CASK2.17459759
21MKNK12.07773239
22MATK2.06910363
23NUAK12.02521958
24MAP3K41.97792950
25ZAK1.96056081
26MOS1.95015979
27MKNK21.92134949
28MAP2K71.85445194
29STK101.83529580
30FRK1.82429732
31PLK31.76496946
32VRK21.74245891
33PLK21.69635906
34STK161.69283483
35NTRK11.67927777
36AKT31.65166014
37FGFR21.62996839
38EIF2AK31.59457243
39PLK41.56545669
40CDK71.55435477
41EPHA21.47999985
42MAP2K41.43233135
43BRSK21.42549946
44CAMK41.42442928
45MAPK131.42152043
46TAF11.40904583
47PINK11.40156520
48EPHB21.39943555
49PRKG21.39656443
50VRK11.37909785
51CDK191.37425077
52PAK41.33756112
53MARK21.30890201
54ADRBK11.22784019
55CHEK21.22339138
56CSNK1G11.21283505
57TGFBR11.20030832
58CSNK1G21.16772324
59CSNK1G31.11016411
60PLK11.10341263
61STK391.07889822
62ERBB31.06744228
63OXSR11.05136864
64LATS21.04823928
65MARK11.02184534
66PRKD30.97822296
67BCKDK0.97473987
68CSNK1A1L0.93180909
69HIPK20.91865500
70NME10.91441986
71ATR0.88192973
72ACVR1B0.87231703
73DYRK1B0.86480172
74ALK0.82892898
75MAP3K100.80510931
76FGFR30.80039051
77MAP2K60.79094645
78CHEK10.77852168
79PIM20.76300693
80CDK80.75154678
81AKT20.73336871
82WNK40.73221318
83TSSK60.73140180
84PBK0.72407189
85CDC70.71944391
86MINK10.71342882
87PNCK0.69886527
88MUSK0.67833200
89WEE10.66959252
90PRKCE0.65376828
91MAP3K90.64577744
92UHMK10.63971157
93INSRR0.62867422
94MAPK120.60511661
95EPHA30.59331428
96RPS6KA40.58907873
97BUB10.58719891
98EIF2AK20.56568287
99WNK30.55981587
100AURKA0.54704567
101PRKCI0.53276415
102BRSK10.52123782
103STK30.52071658
104CSK0.50660336
105TAOK30.50170348
106MTOR0.48043449
107MAP3K70.47155797
108CDK20.46150454
109DYRK20.45859838
110PKN10.45401475
111TIE10.45280608
112CSNK1E0.44304394
113PASK0.43594929
114CSNK1A10.43035136
115SRPK10.41411373
116RPS6KB20.41233921
117CDK30.39420733
118EIF2AK10.39204560
119FGFR10.39143383
120CAMK2A0.38954202
121CSNK2A10.38178423
122NLK0.37631078
123PIK3CA0.37508025
124PTK20.36518209
125ATM0.35810349
126IGF1R0.35808732
127PDK40.34772916
128PDK30.34772916
129NEK20.33618329
130SIK30.33526914
131PRKDC0.32758205
132MAPK100.32001876
133ERBB20.31993363
134NTRK20.31423128
135NEK10.31094444
136PAK10.30525490
137PRKCG0.28784975
138STK380.28725414
139CDK150.28588441
140CDK10.28347757
141CDK180.26698888
142PRKCD0.26157006
143PAK30.26145567
144DYRK1A0.24829250
145CDK11A0.24785337
146AURKB0.24289968
147GSK3B0.23754572
148PDK20.23081707
149CDK140.22284479
150NTRK30.21884192
151INSR0.21828480
152CDK40.21770212
153GSK3A0.20690477
154PRKACG0.19486466
155PRKACB0.19247773
156MAPK140.18761627
157ICK0.18563179
158PRKACA0.17632927
159PAK60.16786357
160MAPK10.16328104
161PDGFRA0.15356694
162ITK0.13948668
163STK38L0.13713087
164RPS6KA30.13171632
165PRKAA10.12046532
166DYRK30.11561564
167MST40.11312053
168MET0.09081964
169BRD40.08764350
170CSNK1D0.08567197
171MAPK40.08397346
172PRPF4B0.06129612

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.89480270
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.66295954
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.35328173
4Fructose and mannose metabolism_Homo sapiens_hsa000513.97098554
5Proteasome_Homo sapiens_hsa030503.17115948
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03690097
7Protein export_Homo sapiens_hsa030602.96431268
8Arachidonic acid metabolism_Homo sapiens_hsa005902.75403206
9Oxidative phosphorylation_Homo sapiens_hsa001902.69087365
10Galactose metabolism_Homo sapiens_hsa000522.53293851
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.43338466
12Linoleic acid metabolism_Homo sapiens_hsa005912.40273698
13Parkinsons disease_Homo sapiens_hsa050122.36894937
14Non-homologous end-joining_Homo sapiens_hsa034502.30538099
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27618381
16Propanoate metabolism_Homo sapiens_hsa006402.20563820
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05486727
18Huntingtons disease_Homo sapiens_hsa050162.03297844
19RNA transport_Homo sapiens_hsa030131.98013141
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72819663
21Steroid biosynthesis_Homo sapiens_hsa001001.69802159
22Base excision repair_Homo sapiens_hsa034101.61674964
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58377490
24mRNA surveillance pathway_Homo sapiens_hsa030151.51979901
25Butanoate metabolism_Homo sapiens_hsa006501.51215884
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50038371
27Phototransduction_Homo sapiens_hsa047441.48764494
28Thyroid cancer_Homo sapiens_hsa052161.48584672
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48062970
30mTOR signaling pathway_Homo sapiens_hsa041501.46540968
31Alzheimers disease_Homo sapiens_hsa050101.40245336
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38420507
33Nucleotide excision repair_Homo sapiens_hsa034201.35836092
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35577824
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33774468
36Fanconi anemia pathway_Homo sapiens_hsa034601.30271317
37Fatty acid elongation_Homo sapiens_hsa000621.25114767
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22371163
39Ether lipid metabolism_Homo sapiens_hsa005651.21752826
40Ovarian steroidogenesis_Homo sapiens_hsa049131.20400075
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19680176
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17523946
43Nitrogen metabolism_Homo sapiens_hsa009101.16712746
44Nicotine addiction_Homo sapiens_hsa050331.15021896
45Caffeine metabolism_Homo sapiens_hsa002321.14769448
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13759760
47Cell cycle_Homo sapiens_hsa041101.13682412
48Hedgehog signaling pathway_Homo sapiens_hsa043401.12792206
49Ribosome_Homo sapiens_hsa030101.12388375
50Basal cell carcinoma_Homo sapiens_hsa052171.07952879
51RNA degradation_Homo sapiens_hsa030181.07860015
52Mismatch repair_Homo sapiens_hsa034301.06400276
53Pyrimidine metabolism_Homo sapiens_hsa002401.04002994
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02470912
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01368958
56Pyruvate metabolism_Homo sapiens_hsa006200.99459186
57Peroxisome_Homo sapiens_hsa041460.98019955
58beta-Alanine metabolism_Homo sapiens_hsa004100.97647741
59Purine metabolism_Homo sapiens_hsa002300.96828337
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.96450918
61Inositol phosphate metabolism_Homo sapiens_hsa005620.95769467
62Chemical carcinogenesis_Homo sapiens_hsa052040.93991391
63One carbon pool by folate_Homo sapiens_hsa006700.92940057
64DNA replication_Homo sapiens_hsa030300.91755544
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90186586
66Homologous recombination_Homo sapiens_hsa034400.89431260
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87853658
68Spliceosome_Homo sapiens_hsa030400.86863955
69Selenocompound metabolism_Homo sapiens_hsa004500.86259195
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84773490
71Glutathione metabolism_Homo sapiens_hsa004800.82367143
72TGF-beta signaling pathway_Homo sapiens_hsa043500.81732779
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80161788
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78964667
75Taste transduction_Homo sapiens_hsa047420.77279834
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75835282
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74647992
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73224081
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.72133783
80Pathways in cancer_Homo sapiens_hsa052000.71676350
81RNA polymerase_Homo sapiens_hsa030200.71524590
82Hippo signaling pathway_Homo sapiens_hsa043900.71426378
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70960373
84Choline metabolism in cancer_Homo sapiens_hsa052310.70861650
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.70482490
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69107744
87Retinol metabolism_Homo sapiens_hsa008300.67940476
88Other glycan degradation_Homo sapiens_hsa005110.67562169
89Basal transcription factors_Homo sapiens_hsa030220.65453906
90Fatty acid metabolism_Homo sapiens_hsa012120.63029248
91Olfactory transduction_Homo sapiens_hsa047400.62394822
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62182752
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61846394
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60575503
95Serotonergic synapse_Homo sapiens_hsa047260.59944936
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59171979
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.58260165
98Rap1 signaling pathway_Homo sapiens_hsa040150.57477836
99Fatty acid degradation_Homo sapiens_hsa000710.56260236
100Carbon metabolism_Homo sapiens_hsa012000.55985697
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.55760268
102Wnt signaling pathway_Homo sapiens_hsa043100.55157693
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.53052051
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52735961
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.50363457
106Tight junction_Homo sapiens_hsa045300.50017053
107Pentose phosphate pathway_Homo sapiens_hsa000300.49453238
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48305612
109Vitamin digestion and absorption_Homo sapiens_hsa049770.47878420
110Fat digestion and absorption_Homo sapiens_hsa049750.47604276
111MicroRNAs in cancer_Homo sapiens_hsa052060.46701437
112p53 signaling pathway_Homo sapiens_hsa041150.46615525
113Regulation of autophagy_Homo sapiens_hsa041400.44265890
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44072260
115GABAergic synapse_Homo sapiens_hsa047270.43800810
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43577034
117Folate biosynthesis_Homo sapiens_hsa007900.43399570
118Arginine and proline metabolism_Homo sapiens_hsa003300.43307452
119Circadian rhythm_Homo sapiens_hsa047100.42989256
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42771186
121Axon guidance_Homo sapiens_hsa043600.41103011
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40650360
123Collecting duct acid secretion_Homo sapiens_hsa049660.40501215
124African trypanosomiasis_Homo sapiens_hsa051430.40354070
125Tryptophan metabolism_Homo sapiens_hsa003800.39639745
126Long-term depression_Homo sapiens_hsa047300.38971526
127Glutamatergic synapse_Homo sapiens_hsa047240.37227754
128Biosynthesis of amino acids_Homo sapiens_hsa012300.36893273
129Sulfur relay system_Homo sapiens_hsa041220.35343797
130Oocyte meiosis_Homo sapiens_hsa041140.33917373
131Lysine degradation_Homo sapiens_hsa003100.33742552
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.33643249
133Histidine metabolism_Homo sapiens_hsa003400.32849834
134Cardiac muscle contraction_Homo sapiens_hsa042600.31355892
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31011122
136AMPK signaling pathway_Homo sapiens_hsa041520.30428999
137Metabolic pathways_Homo sapiens_hsa011000.30031653
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29113164
139Ras signaling pathway_Homo sapiens_hsa040140.29050274
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28180269
141Bladder cancer_Homo sapiens_hsa052190.26981870
142Non-small cell lung cancer_Homo sapiens_hsa052230.23678151
143Notch signaling pathway_Homo sapiens_hsa043300.23388589
144GnRH signaling pathway_Homo sapiens_hsa049120.22996451
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22731156
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.20638854
147Acute myeloid leukemia_Homo sapiens_hsa052210.19094833
148VEGF signaling pathway_Homo sapiens_hsa043700.18487507
149Protein digestion and absorption_Homo sapiens_hsa049740.18187904
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17611023
151Calcium signaling pathway_Homo sapiens_hsa040200.17322891
152Long-term potentiation_Homo sapiens_hsa047200.17322467
153Proteoglycans in cancer_Homo sapiens_hsa052050.17250303
154Dorso-ventral axis formation_Homo sapiens_hsa043200.16314557
155Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15154911

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