ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	8.21246772
2	cilium or flagellum-dependent cell motility (GO:0001539)	7.03040945
3	piRNA metabolic process (GO:0034587)	6.60687669
4	axonemal dynein complex assembly (GO:0070286)	6.52666649
5	negative regulation of cAMP-mediated signaling (GO:0043951)	6.16591861
6	opioid receptor signaling pathway (GO:0038003)	5.98422073
7	behavioral response to ethanol (GO:0048149)	5.97603180
8	cilium movement (GO:0003341)	5.92807916
9	epithelial cilium movement (GO:0003351)	5.92194143
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.60493918
11	regulation of acrosome reaction (GO:0060046)	5.21800610
12	adult feeding behavior (GO:0008343)	5.04726144
13	sphingosine metabolic process (GO:0006670)	5.01336964
14	sphingoid metabolic process (GO:0046519)	4.94017236
15	axoneme assembly (GO:0035082)	4.88026849
16	diol metabolic process (GO:0034311)	4.76372454
17	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.73929811
18	sperm motility (GO:0030317)	4.67748226
19	motile cilium assembly (GO:0044458)	4.65173222
20	regulation of protein glycosylation (GO:0060049)	4.52828826
21	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.49829561
22	ether lipid metabolic process (GO:0046485)	4.47600467
23	left/right axis specification (GO:0070986)	4.37596216
24	positive regulation of cAMP-mediated signaling (GO:0043950)	3.96599034
25	DNA methylation involved in gamete generation (GO:0043046)	3.95631847
26	cellular ketone body metabolic process (GO:0046950)	3.86785592
27	indole-containing compound catabolic process (GO:0042436)	3.82034613
28	indolalkylamine catabolic process (GO:0046218)	3.82034613
29	tryptophan catabolic process (GO:0006569)	3.82034613
30	acrosome reaction (GO:0007340)	3.78134042
31	spermatid development (GO:0007286)	3.77435770
32	indolalkylamine metabolic process (GO:0006586)	3.69573225
33	regulation of cilium movement (GO:0003352)	3.67969619
34	regulation of translational termination (GO:0006449)	3.58483976
35	nephron tubule morphogenesis (GO:0072078)	3.55204936
36	nephron epithelium morphogenesis (GO:0072088)	3.55204936
37	photoreceptor cell maintenance (GO:0045494)	3.45938270
38	ketone body metabolic process (GO:1902224)	3.39669355
39	cornea development in camera-type eye (GO:0061303)	3.37069516
40	detection of light stimulus involved in sensory perception (GO:0050962)	3.30234840
41	detection of light stimulus involved in visual perception (GO:0050908)	3.30234840
42	cilium organization (GO:0044782)	3.22581787
43	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.21216773
44	cilium morphogenesis (GO:0060271)	3.18911966
45	regulation of meiosis I (GO:0060631)	3.18410616
46	organic cation transport (GO:0015695)	3.17773276
47	multicellular organism reproduction (GO:0032504)	3.16311215
48	centriole replication (GO:0007099)	3.12680350
49	cilium assembly (GO:0042384)	3.10275974
50	centriole assembly (GO:0098534)	3.09947024
51	protein polyglutamylation (GO:0018095)	3.06827897
52	coenzyme catabolic process (GO:0009109)	3.06325921
53	retinal cone cell development (GO:0046549)	3.03662237
54	glycerol ether metabolic process (GO:0006662)	3.01304192
55	fucose catabolic process (GO:0019317)	2.99426645
56	L-fucose metabolic process (GO:0042354)	2.99426645
57	L-fucose catabolic process (GO:0042355)	2.99426645
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98495306
59	neuronal action potential (GO:0019228)	2.98316841
60	establishment of protein localization to Golgi (GO:0072600)	2.98190037
61	tryptophan metabolic process (GO:0006568)	2.96571453
62	protein localization to Golgi apparatus (GO:0034067)	2.95429650
63	pyrimidine dimer repair (GO:0006290)	2.94734778
64	vitamin transmembrane transport (GO:0035461)	2.94134304
65	positive regulation of meiosis (GO:0045836)	2.89449612
66	regulation of microtubule-based movement (GO:0060632)	2.88053394
67	response to pheromone (GO:0019236)	2.87923099
68	glomerular epithelial cell development (GO:0072310)	2.87521779
69	aromatic amino acid family catabolic process (GO:0009074)	2.87440230
70	sperm capacitation (GO:0048240)	2.86793784
71	ether metabolic process (GO:0018904)	2.86670395
72	kynurenine metabolic process (GO:0070189)	2.85939813
73	regulation of memory T cell differentiation (GO:0043380)	2.83035464
74	behavioral response to nicotine (GO:0035095)	2.81234275
75	notochord development (GO:0030903)	2.80424007
76	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.79031221
77	exogenous drug catabolic process (GO:0042738)	2.78006166
78	gene silencing by RNA (GO:0031047)	2.77547609
79	drug catabolic process (GO:0042737)	2.75792605
80	ncRNA catabolic process (GO:0034661)	2.74174664
81	protein targeting to Golgi (GO:0000042)	2.74030799
82	glycerophospholipid catabolic process (GO:0046475)	2.73760992
83	thrombin receptor signaling pathway (GO:0070493)	2.73054748
84	positive regulation of meiotic cell cycle (GO:0051446)	2.71667393
85	thyroid hormone metabolic process (GO:0042403)	2.70796737
86	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.68152839
87	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.67142352
88	phosphatidylethanolamine metabolic process (GO:0046337)	2.67092783
89	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.66927420
90	fusion of sperm to egg plasma membrane (GO:0007342)	2.66820923
91	amine catabolic process (GO:0009310)	2.65914290
92	cellular biogenic amine catabolic process (GO:0042402)	2.65914290
93	male meiosis (GO:0007140)	2.65550798
94	indole-containing compound metabolic process (GO:0042430)	2.62630671
95	benzene-containing compound metabolic process (GO:0042537)	2.62309012
96	fertilization (GO:0009566)	2.60953051
97	renal tubule morphogenesis (GO:0061333)	2.60654283
98	regulation of glutamate receptor signaling pathway (GO:1900449)	2.60504762
99	meiotic cell cycle (GO:0051321)	2.59900094
100	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.56385851

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.30450126
2	VDR_22108803_ChIP-Seq_LS180_Human	3.23791895
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.00954227
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.90278367
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.78087360
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34284460
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31763246
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18595190
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.18595190
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.15678062
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15626390
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04626262
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.01202119
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.00798888
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98043109
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93505934
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91384909
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.87947545
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86377752
20	FUS_26573619_Chip-Seq_HEK293_Human	1.85497645
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.85093035
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.85093035
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78464659
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76675567
25	P300_19829295_ChIP-Seq_ESCs_Human	1.74799326
26	STAT3_23295773_ChIP-Seq_U87_Human	1.74619642
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.67064933
28	TCF4_23295773_ChIP-Seq_U87_Human	1.66563045
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.65299488
30	NANOG_19829295_ChIP-Seq_ESCs_Human	1.65299488
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64354950
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56964644
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56866356
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55973570
35	DROSHA_22980978_ChIP-Seq_HELA_Human	1.54693574
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.52335356
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49675781
38	AR_25329375_ChIP-Seq_VCAP_Human	1.47819336
39	RXR_22108803_ChIP-Seq_LS180_Human	1.45213376
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44138276
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44005685
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42624089
43	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40864035
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38984855
45	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.37197391
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37026470
47	EZH2_22144423_ChIP-Seq_EOC_Human	1.36411593
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35861436
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34393106
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34177842
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.33299156
52	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32267818
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32209922
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.31344922
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30717910
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29648975
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29111757
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28466003
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28466003
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26264049
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23913302
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23471724
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21881945
64	EWS_26573619_Chip-Seq_HEK293_Human	1.21634238
65	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19531671
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18529605
67	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.18489408
68	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16718532
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.15884739
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15483909
71	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14954211
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13840285
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13248245
74	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.11962514
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.11648899
76	NCOR_22424771_ChIP-Seq_293T_Human	1.11200386
77	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08806891
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07076962
79	TP53_18474530_ChIP-ChIP_U2OS_Human	1.07010142
80	AHR_22903824_ChIP-Seq_MCF-7_Human	1.06265366
81	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.05328929
82	AR_20517297_ChIP-Seq_VCAP_Human	1.05261555
83	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05153969
84	CEBPB_22108803_ChIP-Seq_LS180_Human	1.04202881
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03944132
86	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03871900
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03590193
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.03558109
89	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.03499718
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02145079
91	ETV1_20927104_ChIP-Seq_GIST48_Human	1.01967259
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01559862
93	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00805405
94	ERA_21632823_ChIP-Seq_H3396_Human	1.00061933
95	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.00018064
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.99987552
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99628896
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98781248
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98003125
100	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.97330990

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	4.91790551
2	MP0002876_abnormal_thyroid_physiology	4.48066908
3	MP0003195_calcinosis	3.39660541
4	MP0005551_abnormal_eye_electrophysiolog	2.68102485
5	MP0002837_dystrophic_cardiac_calcinosis	2.60976742
6	MP0008875_abnormal_xenobiotic_pharmacok	2.59498341
7	MP0005410_abnormal_fertilization	2.57559810
8	MP0003646_muscle_fatigue	2.48008057
9	MP0001968_abnormal_touch/_nociception	2.45552073
10	MP0005360_urolithiasis	2.45292329
11	MP0005646_abnormal_pituitary_gland	2.39587747
12	MP0001501_abnormal_sleep_pattern	2.35008155
13	MP0008877_abnormal_DNA_methylation	2.20237635
14	MP0004043_abnormal_pH_regulation	2.13108271
15	MP0003878_abnormal_ear_physiology	2.11426639
16	MP0005377_hearing/vestibular/ear_phenot	2.11426639
17	MP0009278_abnormal_bone_marrow	2.08358968
18	MP0009046_muscle_twitch	1.96908515
19	MP0002653_abnormal_ependyma_morphology	1.78395285
20	MP0003045_fibrosis	1.76655818
21	MP0005645_abnormal_hypothalamus_physiol	1.74736469
22	MP0003879_abnormal_hair_cell	1.68336827
23	MP0000678_abnormal_parathyroid_gland	1.65142243
24	MP0005670_abnormal_white_adipose	1.61217920
25	MP0003698_abnormal_male_reproductive	1.59620209
26	MP0005085_abnormal_gallbladder_physiolo	1.50550617
27	MP0001929_abnormal_gametogenesis	1.49660651
28	MP0003950_abnormal_plasma_membrane	1.47055824
29	MP0008872_abnormal_physiological_respon	1.46729982
30	MP0009745_abnormal_behavioral_response	1.45708774
31	MP0001664_abnormal_digestion	1.45572464
32	MP0010329_abnormal_lipoprotein_level	1.45097675
33	MP0002139_abnormal_hepatobiliary_system	1.44212568
34	MP0003880_abnormal_central_pattern	1.39200710
35	MP0000681_abnormal_thyroid_gland	1.38233671
36	MP0005253_abnormal_eye_physiology	1.37947746
37	MP0003136_yellow_coat_color	1.37035215
38	MP0003183_abnormal_peptide_metabolism	1.36630030
39	MP0009764_decreased_sensitivity_to	1.35390880
40	MP0005365_abnormal_bile_salt	1.33627937
41	MP0004147_increased_porphyrin_level	1.33015062
42	MP0003718_maternal_effect	1.31865888
43	MP0002272_abnormal_nervous_system	1.30759447
44	MP0006072_abnormal_retinal_apoptosis	1.29613222
45	MP0002160_abnormal_reproductive_system	1.25800064
46	MP0003633_abnormal_nervous_system	1.25174917
47	MP0001486_abnormal_startle_reflex	1.24595088
48	MP0002138_abnormal_hepatobiliary_system	1.24112930
49	MP0002168_other_aberrant_phenotype	1.21248109
50	MP0002733_abnormal_thermal_nociception	1.20665448
51	MP0001485_abnormal_pinna_reflex	1.19344867
52	MP0003941_abnormal_skin_development	1.18221328
53	MP0005389_reproductive_system_phenotype	1.15983150
54	MP0006276_abnormal_autonomic_nervous	1.14623328
55	MP0000427_abnormal_hair_cycle	1.14613664
56	MP0001984_abnormal_olfaction	1.13768500
57	MP0005167_abnormal_blood-brain_barrier	1.13366068
58	MP0000569_abnormal_digit_pigmentation	1.09892515
59	MP0005395_other_phenotype	1.08246231
60	MP0000230_abnormal_systemic_arterial	1.05423850
61	MP0000015_abnormal_ear_pigmentation	1.05101127
62	MP0001970_abnormal_pain_threshold	1.02599978
63	MP0002229_neurodegeneration	1.02406437
64	MP0000383_abnormal_hair_follicle	1.02197336
65	MP0005332_abnormal_amino_acid	1.01913041
66	MP0006035_abnormal_mitochondrial_morpho	1.01019158
67	MP0002693_abnormal_pancreas_physiology	1.00230423
68	MP0002557_abnormal_social/conspecific_i	0.97233814
69	MP0005379_endocrine/exocrine_gland_phen	0.96003312
70	MP0001324_abnormal_eye_pigmentation	0.95378965
71	MP0001765_abnormal_ion_homeostasis	0.94316822
72	MP0003252_abnormal_bile_duct	0.91804644
73	MP0001764_abnormal_homeostasis	0.91587324
74	MP0005503_abnormal_tendon_morphology	0.91563577
75	MP0002210_abnormal_sex_determination	0.91261384
76	MP0005310_abnormal_salivary_gland	0.90137493
77	MP0002735_abnormal_chemical_nociception	0.89786540
78	MP0002249_abnormal_larynx_morphology	0.88762591
79	MP0002971_abnormal_brown_adipose	0.87622660
80	MP0004133_heterotaxia	0.87176470
81	MP0001545_abnormal_hematopoietic_system	0.87166179
82	MP0005397_hematopoietic_system_phenotyp	0.87166179
83	MP0003631_nervous_system_phenotype	0.84543941
84	MP0005195_abnormal_posterior_eye	0.83866336
85	MP0001270_distended_abdomen	0.83016978
86	MP0001919_abnormal_reproductive_system	0.82867012
87	MP0005636_abnormal_mineral_homeostasis	0.81188994
88	MP0002102_abnormal_ear_morphology	0.80869671
89	MP0003959_abnormal_lean_body	0.80083338
90	MP0002909_abnormal_adrenal_gland	0.79882196
91	MP0002572_abnormal_emotion/affect_behav	0.79045106
92	MP0008775_abnormal_heart_ventricle	0.78341580
93	MP0003638_abnormal_response/metabolism_	0.77672522
94	MP0010678_abnormal_skin_adnexa	0.75771243
95	MP0004215_abnormal_myocardial_fiber	0.75431642
96	MP0001756_abnormal_urination	0.75332752
97	MP0002938_white_spotting	0.74634095
98	MP0004019_abnormal_vitamin_homeostasis	0.74265815
99	MP0001963_abnormal_hearing_physiology	0.73706245
100	MP0005647_abnormal_sex_gland	0.73527015

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	6.29373011
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.60290975
3	Absent/shortened dynein arms (HP:0200106)	5.60290975
4	Abnormal respiratory epithelium morphology (HP:0012253)	5.32963023
5	Abnormal respiratory motile cilium morphology (HP:0005938)	5.32963023
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.19595871
7	Abnormal ciliary motility (HP:0012262)	5.18203326
8	Abnormal respiratory motile cilium physiology (HP:0012261)	5.00291694
9	Rhinitis (HP:0012384)	4.36872633
10	Pancreatic cysts (HP:0001737)	3.95240983
11	Pancreatic fibrosis (HP:0100732)	3.73460699
12	Intestinal atresia (HP:0011100)	3.67374583
13	Tubular atrophy (HP:0000092)	3.66389875
14	Nephronophthisis (HP:0000090)	3.54963703
15	Abnormality of midbrain morphology (HP:0002418)	3.51815709
16	Molar tooth sign on MRI (HP:0002419)	3.51815709
17	Pancreatic islet-cell hyperplasia (HP:0004510)	3.44809157
18	True hermaphroditism (HP:0010459)	3.43891842
19	Chronic hepatic failure (HP:0100626)	3.40332512
20	Large for gestational age (HP:0001520)	3.33341791
21	Volvulus (HP:0002580)	3.30724810
22	Gaze-evoked nystagmus (HP:0000640)	3.18909836
23	Abnormality of the renal medulla (HP:0100957)	3.18508966
24	Bronchiectasis (HP:0002110)	3.17797856
25	Attenuation of retinal blood vessels (HP:0007843)	3.14434762
26	Chronic bronchitis (HP:0004469)	3.06271649
27	Abnormality of macular pigmentation (HP:0008002)	3.05829188
28	Congenital stationary night blindness (HP:0007642)	3.04748663
29	Type II lissencephaly (HP:0007260)	3.02003525
30	Cystic liver disease (HP:0006706)	2.97282916
31	Amelogenesis imperfecta (HP:0000705)	2.88682431
32	Abnormality of the renal cortex (HP:0011035)	2.88369857
33	Abnormality of the aortic arch (HP:0012303)	2.75187100
34	Cerebellar dysplasia (HP:0007033)	2.71030077
35	Severe visual impairment (HP:0001141)	2.67899253
36	Decreased circulating renin level (HP:0003351)	2.58975201
37	Decreased central vision (HP:0007663)	2.58474139
38	Abnormal drinking behavior (HP:0030082)	2.57238872
39	Polydipsia (HP:0001959)	2.57238872
40	Broad alveolar ridges (HP:0000187)	2.54073842
41	Pendular nystagmus (HP:0012043)	2.53885674
42	Focal motor seizures (HP:0011153)	2.52967416
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.52669412
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.50796345
45	Agitation (HP:0000713)	2.41674303
46	Abolished electroretinogram (ERG) (HP:0000550)	2.38159923
47	Pigmentary retinal degeneration (HP:0001146)	2.34816667
48	Keratoconus (HP:0000563)	2.33424040
49	Increased corneal curvature (HP:0100692)	2.33424040
50	Medial flaring of the eyebrow (HP:0010747)	2.21518158
51	Thickened helices (HP:0000391)	2.19329729
52	Occipital encephalocele (HP:0002085)	2.14445435
53	Tubulointerstitial nephritis (HP:0001970)	2.12397499
54	Hyperkalemia (HP:0002153)	2.11758458
55	Progressive inability to walk (HP:0002505)	2.10457394
56	Abnormality of the pancreatic islet cells (HP:0006476)	2.10035219
57	Abnormality of endocrine pancreas physiology (HP:0012093)	2.10035219
58	Hyperventilation (HP:0002883)	2.09803686
59	Poor head control (HP:0002421)	2.08444704
60	Congenital hepatic fibrosis (HP:0002612)	2.08168758
61	Sclerocornea (HP:0000647)	2.07678464
62	Dialeptic seizures (HP:0011146)	2.05266035
63	Lissencephaly (HP:0001339)	2.02768369
64	Infertility (HP:0000789)	2.02268570
65	Oligodontia (HP:0000677)	2.01643419
66	Furrowed tongue (HP:0000221)	2.01398483
67	Polyuria (HP:0000103)	2.00852918
68	Inability to walk (HP:0002540)	1.98856411
69	Abnormality of the ileum (HP:0001549)	1.98160628
70	Male pseudohermaphroditism (HP:0000037)	1.98015701
71	Postaxial foot polydactyly (HP:0001830)	1.96090981
72	Central scotoma (HP:0000603)	1.94957800
73	Congenital sensorineural hearing impairment (HP:0008527)	1.94242779
74	Gastrointestinal atresia (HP:0002589)	1.93940097
75	Mesangial abnormality (HP:0001966)	1.90653606
76	Abnormal urine output (HP:0012590)	1.90549733
77	Abnormality of the vitreous humor (HP:0004327)	1.90367307
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90124706
79	Tubulointerstitial abnormality (HP:0001969)	1.88839974
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.88541840
81	Broad-based gait (HP:0002136)	1.87132945
82	Nasal polyposis (HP:0100582)	1.87094987
83	Cone-rod dystrophy (HP:0000548)	1.85587811
84	Retinitis pigmentosa (HP:0000510)	1.84196466
85	Abnormality of renal excretion (HP:0011036)	1.82697764
86	Anencephaly (HP:0002323)	1.80008721
87	Abnormality of dental color (HP:0011073)	1.79813173
88	Bile duct proliferation (HP:0001408)	1.79623750
89	Abnormal biliary tract physiology (HP:0012439)	1.79623750
90	Ketoacidosis (HP:0001993)	1.79142663
91	Absent speech (HP:0001344)	1.76253766
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.75956232
93	Optic nerve hypoplasia (HP:0000609)	1.75578827
94	Progressive cerebellar ataxia (HP:0002073)	1.75174925
95	Facial shape deformation (HP:0011334)	1.73659488
96	Potter facies (HP:0002009)	1.73659488
97	Scotoma (HP:0000575)	1.71584851
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.70612693
99	Congenital primary aphakia (HP:0007707)	1.70508622
100	Focal seizures (HP:0007359)	1.70367219

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.04147876
2	ADRBK2	6.77091312
3	PINK1	3.64077301
4	STK38L	3.00388770
5	ACVR1B	2.88127825
6	WNK4	2.30619730
7	PNCK	2.17830949
8	LATS1	2.08799192
9	BMPR1B	2.06138129
10	ZAK	1.77924039
11	MST4	1.76335286
12	ADRBK1	1.72890149
13	GRK1	1.71786250
14	INSRR	1.71306908
15	MAPK15	1.71248197
16	PRKD3	1.66690801
17	STK38	1.50471682
18	WNK3	1.44947598
19	MAP4K2	1.38800685
20	PTK2B	1.38743867
21	STK39	1.36786430
22	STK3	1.33566537
23	PRKCE	1.33283327
24	OXSR1	1.32129102
25	PLK4	1.27378544
26	PRKCG	1.15950388
27	AKT3	1.15143435
28	DAPK2	1.13763472
29	PLK2	1.06127749
30	BRSK2	1.05069803
31	FLT3	1.03968106
32	MAPK13	0.95686051
33	IRAK1	0.93657217
34	TGFBR1	0.93256884
35	TLK1	0.91311064
36	PIK3CG	0.87230684
37	NEK2	0.86204351
38	MAPKAPK3	0.80577061
39	CAMK1G	0.79746130
40	FGFR2	0.79735090
41	TAOK3	0.78743701
42	ERN1	0.76330831
43	MAPKAPK5	0.76285422
44	MAP3K4	0.74783265
45	PRKAA2	0.74613443
46	NTRK3	0.73034301
47	TRPM7	0.72970404
48	MAPK11	0.72435994
49	MUSK	0.68806823
50	NUAK1	0.68365225
51	PRKCI	0.66077014
52	CASK	0.60738431
53	CSNK1A1L	0.60391805
54	SIK2	0.60312367
55	BRD4	0.59571539
56	TNIK	0.59083965
57	CAMK2A	0.58964627
58	MAP3K7	0.57365960
59	MAP3K2	0.55531219
60	BCR	0.54830540
61	MAP2K6	0.54563934
62	TIE1	0.53839020
63	TRIM28	0.52708068
64	DYRK3	0.52575075
65	TYRO3	0.50533429
66	EIF2AK3	0.49948340
67	ERBB2	0.48551610
68	IRAK3	0.48181202
69	OBSCN	0.46957466
70	PIK3CA	0.46422166
71	NME1	0.44731881
72	FER	0.44550371
73	CSNK1G2	0.44333841
74	PDK1	0.44044005
75	PHKG2	0.41500488
76	PHKG1	0.41500488
77	CAMK1	0.39984362
78	CSNK1G1	0.39480456
79	PRKAA1	0.39343056
80	PDPK1	0.38559019
81	MELK	0.38544265
82	CSNK1G3	0.38542519
83	SGK1	0.38221807
84	MKNK2	0.35988003
85	CSF1R	0.35947583
86	PRKACA	0.34759332
87	NLK	0.34582633
88	CSNK1A1	0.33679028
89	PRKG1	0.33555880
90	MAP2K2	0.33542738
91	CSNK1D	0.31316938
92	TXK	0.31075397
93	PRKCA	0.30081454
94	MAP2K7	0.29444748
95	NEK9	0.29400419
96	PRKCQ	0.29341626
97	MAP2K1	0.28332650
98	PAK3	0.27781802
99	WNK1	0.27637218
100	BRSK1	0.27577239

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.70029702
2	Butanoate metabolism_Homo sapiens_hsa00650	2.63317198
3	ABC transporters_Homo sapiens_hsa02010	2.54399481
4	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.52046512
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.36874584
6	Olfactory transduction_Homo sapiens_hsa04740	2.24592014
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20459139
8	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.19902835
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.19458657
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16670167
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14939899
12	Sphingolipid metabolism_Homo sapiens_hsa00600	2.11428442
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.10933828
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.06924083
15	Tryptophan metabolism_Homo sapiens_hsa00380	2.06038546
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03619414
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.94618306
18	Histidine metabolism_Homo sapiens_hsa00340	1.94383946
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88644725
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86960948
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.85427591
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.85100054
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76699628
24	Retinol metabolism_Homo sapiens_hsa00830	1.69165503
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.68609950
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.63223588
27	Taste transduction_Homo sapiens_hsa04742	1.59260223
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.52820841
29	Caffeine metabolism_Homo sapiens_hsa00232	1.52776807
30	Fatty acid degradation_Homo sapiens_hsa00071	1.45595789
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.43138669
32	Nicotine addiction_Homo sapiens_hsa05033	1.42329446
33	Morphine addiction_Homo sapiens_hsa05032	1.42235513
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40088221
35	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.39182728
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37439570
37	Glycerolipid metabolism_Homo sapiens_hsa00561	1.34358736
38	Peroxisome_Homo sapiens_hsa04146	1.33523521
39	beta-Alanine metabolism_Homo sapiens_hsa00410	1.27251622
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.24937817
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.19941333
42	Complement and coagulation cascades_Homo sapiens_hsa04610	1.19826428
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.16880893
44	Propanoate metabolism_Homo sapiens_hsa00640	1.13256481
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10274992
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08129917
47	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.04948678
48	Salivary secretion_Homo sapiens_hsa04970	0.97998677
49	Tyrosine metabolism_Homo sapiens_hsa00350	0.96032589
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.95668825
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.91516780
52	Basal transcription factors_Homo sapiens_hsa03022	0.90001026
53	Sulfur metabolism_Homo sapiens_hsa00920	0.87643917
54	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.85977247
55	Phenylalanine metabolism_Homo sapiens_hsa00360	0.84660506
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.84308213
57	Serotonergic synapse_Homo sapiens_hsa04726	0.83363901
58	Mineral absorption_Homo sapiens_hsa04978	0.79060092
59	Insulin secretion_Homo sapiens_hsa04911	0.77308990
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76482491
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.74785736
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.74397265
63	Homologous recombination_Homo sapiens_hsa03440	0.74266711
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.73336823
65	Circadian entrainment_Homo sapiens_hsa04713	0.72599454
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.71165752
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68269174
68	Metabolic pathways_Homo sapiens_hsa01100	0.66517497
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65837655
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.63506901
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62403573
72	GABAergic synapse_Homo sapiens_hsa04727	0.62328185
73	Glutathione metabolism_Homo sapiens_hsa00480	0.60745644
74	Circadian rhythm_Homo sapiens_hsa04710	0.58790647
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.58260309
76	Arginine biosynthesis_Homo sapiens_hsa00220	0.56241476
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55823476
78	Sulfur relay system_Homo sapiens_hsa04122	0.52631260
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.52131552
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51308689
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51281018
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.49076409
83	Regulation of autophagy_Homo sapiens_hsa04140	0.47931810
84	Bile secretion_Homo sapiens_hsa04976	0.44420624
85	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42542438
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.42181173
87	Purine metabolism_Homo sapiens_hsa00230	0.39141955
88	Asthma_Homo sapiens_hsa05310	0.36483255
89	Long-term depression_Homo sapiens_hsa04730	0.33729813
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30844758
91	One carbon pool by folate_Homo sapiens_hsa00670	0.30242253
92	Renin secretion_Homo sapiens_hsa04924	0.29910457
93	Huntingtons disease_Homo sapiens_hsa05016	0.28694484
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.24339070
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.23826222
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22096728
97	Pancreatic secretion_Homo sapiens_hsa04972	0.21138786
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.21051997
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.20393481
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20160963

CCDC162P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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