CCDC162P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)8.21246772
2cilium or flagellum-dependent cell motility (GO:0001539)7.03040945
3piRNA metabolic process (GO:0034587)6.60687669
4axonemal dynein complex assembly (GO:0070286)6.52666649
5negative regulation of cAMP-mediated signaling (GO:0043951)6.16591861
6opioid receptor signaling pathway (GO:0038003)5.98422073
7behavioral response to ethanol (GO:0048149)5.97603180
8cilium movement (GO:0003341)5.92807916
9epithelial cilium movement (GO:0003351)5.92194143
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.60493918
11regulation of acrosome reaction (GO:0060046)5.21800610
12adult feeding behavior (GO:0008343)5.04726144
13sphingosine metabolic process (GO:0006670)5.01336964
14sphingoid metabolic process (GO:0046519)4.94017236
15axoneme assembly (GO:0035082)4.88026849
16diol metabolic process (GO:0034311)4.76372454
17negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.73929811
18sperm motility (GO:0030317)4.67748226
19motile cilium assembly (GO:0044458)4.65173222
20regulation of protein glycosylation (GO:0060049)4.52828826
21adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.49829561
22ether lipid metabolic process (GO:0046485)4.47600467
23left/right axis specification (GO:0070986)4.37596216
24positive regulation of cAMP-mediated signaling (GO:0043950)3.96599034
25DNA methylation involved in gamete generation (GO:0043046)3.95631847
26cellular ketone body metabolic process (GO:0046950)3.86785592
27indole-containing compound catabolic process (GO:0042436)3.82034613
28indolalkylamine catabolic process (GO:0046218)3.82034613
29tryptophan catabolic process (GO:0006569)3.82034613
30acrosome reaction (GO:0007340)3.78134042
31spermatid development (GO:0007286)3.77435770
32indolalkylamine metabolic process (GO:0006586)3.69573225
33regulation of cilium movement (GO:0003352)3.67969619
34regulation of translational termination (GO:0006449)3.58483976
35nephron epithelium morphogenesis (GO:0072088)3.55204936
36nephron tubule morphogenesis (GO:0072078)3.55204936
37photoreceptor cell maintenance (GO:0045494)3.45938270
38ketone body metabolic process (GO:1902224)3.39669355
39cornea development in camera-type eye (GO:0061303)3.37069516
40detection of light stimulus involved in sensory perception (GO:0050962)3.30234840
41detection of light stimulus involved in visual perception (GO:0050908)3.30234840
42cilium organization (GO:0044782)3.22581787
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21216773
44cilium morphogenesis (GO:0060271)3.18911966
45regulation of meiosis I (GO:0060631)3.18410616
46organic cation transport (GO:0015695)3.17773276
47multicellular organism reproduction (GO:0032504)3.16311215
48centriole replication (GO:0007099)3.12680350
49cilium assembly (GO:0042384)3.10275974
50centriole assembly (GO:0098534)3.09947024
51protein polyglutamylation (GO:0018095)3.06827897
52coenzyme catabolic process (GO:0009109)3.06325921
53retinal cone cell development (GO:0046549)3.03662237
54glycerol ether metabolic process (GO:0006662)3.01304192
55fucose catabolic process (GO:0019317)2.99426645
56L-fucose metabolic process (GO:0042354)2.99426645
57L-fucose catabolic process (GO:0042355)2.99426645
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98495306
59neuronal action potential (GO:0019228)2.98316841
60establishment of protein localization to Golgi (GO:0072600)2.98190037
61tryptophan metabolic process (GO:0006568)2.96571453
62protein localization to Golgi apparatus (GO:0034067)2.95429650
63pyrimidine dimer repair (GO:0006290)2.94734778
64vitamin transmembrane transport (GO:0035461)2.94134304
65positive regulation of meiosis (GO:0045836)2.89449612
66regulation of microtubule-based movement (GO:0060632)2.88053394
67response to pheromone (GO:0019236)2.87923099
68glomerular epithelial cell development (GO:0072310)2.87521779
69aromatic amino acid family catabolic process (GO:0009074)2.87440230
70sperm capacitation (GO:0048240)2.86793784
71ether metabolic process (GO:0018904)2.86670395
72kynurenine metabolic process (GO:0070189)2.85939813
73regulation of memory T cell differentiation (GO:0043380)2.83035464
74behavioral response to nicotine (GO:0035095)2.81234275
75notochord development (GO:0030903)2.80424007
76negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79031221
77exogenous drug catabolic process (GO:0042738)2.78006166
78gene silencing by RNA (GO:0031047)2.77547609
79drug catabolic process (GO:0042737)2.75792605
80ncRNA catabolic process (GO:0034661)2.74174664
81protein targeting to Golgi (GO:0000042)2.74030799
82glycerophospholipid catabolic process (GO:0046475)2.73760992
83thrombin receptor signaling pathway (GO:0070493)2.73054748
84positive regulation of meiotic cell cycle (GO:0051446)2.71667393
85thyroid hormone metabolic process (GO:0042403)2.70796737
86detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.68152839
87phosphatidylethanolamine biosynthetic process (GO:0006646)2.67142352
88phosphatidylethanolamine metabolic process (GO:0046337)2.67092783
89negative regulation of nitric oxide biosynthetic process (GO:0045019)2.66927420
90fusion of sperm to egg plasma membrane (GO:0007342)2.66820923
91amine catabolic process (GO:0009310)2.65914290
92cellular biogenic amine catabolic process (GO:0042402)2.65914290
93male meiosis (GO:0007140)2.65550798
94indole-containing compound metabolic process (GO:0042430)2.62630671
95benzene-containing compound metabolic process (GO:0042537)2.62309012
96fertilization (GO:0009566)2.60953051
97renal tubule morphogenesis (GO:0061333)2.60654283
98regulation of glutamate receptor signaling pathway (GO:1900449)2.60504762
99meiotic cell cycle (GO:0051321)2.59900094
100regulation of calcium ion-dependent exocytosis (GO:0017158)2.56385851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.30450126
2VDR_22108803_ChIP-Seq_LS180_Human3.23791895
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.00954227
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90278367
5GBX2_23144817_ChIP-Seq_PC3_Human2.78087360
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34284460
7IGF1R_20145208_ChIP-Seq_DFB_Human2.31763246
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18595190
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.18595190
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15678062
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15626390
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.04626262
13TAF15_26573619_Chip-Seq_HEK293_Human2.01202119
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00798888
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98043109
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93505934
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91384909
18ER_23166858_ChIP-Seq_MCF-7_Human1.87947545
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86377752
20FUS_26573619_Chip-Seq_HEK293_Human1.85497645
21CBP_20019798_ChIP-Seq_JUKART_Human1.85093035
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.85093035
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78464659
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76675567
25P300_19829295_ChIP-Seq_ESCs_Human1.74799326
26STAT3_23295773_ChIP-Seq_U87_Human1.74619642
27BCAT_22108803_ChIP-Seq_LS180_Human1.67064933
28TCF4_23295773_ChIP-Seq_U87_Human1.66563045
29NANOG_19829295_ChIP-Seq_ESCs_Human1.65299488
30SOX2_19829295_ChIP-Seq_ESCs_Human1.65299488
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.64354950
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56964644
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56866356
34SMAD4_21799915_ChIP-Seq_A2780_Human1.55973570
35DROSHA_22980978_ChIP-Seq_HELA_Human1.54693574
36AR_21572438_ChIP-Seq_LNCaP_Human1.52335356
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49675781
38AR_25329375_ChIP-Seq_VCAP_Human1.47819336
39RXR_22108803_ChIP-Seq_LS180_Human1.45213376
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44138276
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44005685
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.42624089
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.40864035
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.38984855
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37197391
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.37026470
47EZH2_22144423_ChIP-Seq_EOC_Human1.36411593
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35861436
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34393106
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34177842
51CDX2_22108803_ChIP-Seq_LS180_Human1.33299156
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32267818
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32209922
54TCF4_22108803_ChIP-Seq_LS180_Human1.31344922
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30717910
56RUNX2_22187159_ChIP-Seq_PCA_Human1.29648975
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.29111757
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.28466003
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28466003
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26264049
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.23913302
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23471724
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21881945
64EWS_26573619_Chip-Seq_HEK293_Human1.21634238
65NANOG_20526341_ChIP-Seq_ESCs_Human1.19531671
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18529605
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.18489408
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16718532
69TP53_22573176_ChIP-Seq_HFKS_Human1.15884739
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.15483909
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14954211
72HOXB7_26014856_ChIP-Seq_BT474_Human1.13840285
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13248245
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11962514
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.11648899
76NCOR_22424771_ChIP-Seq_293T_Human1.11200386
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08806891
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07076962
79TP53_18474530_ChIP-ChIP_U2OS_Human1.07010142
80AHR_22903824_ChIP-Seq_MCF-7_Human1.06265366
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05328929
82AR_20517297_ChIP-Seq_VCAP_Human1.05261555
83OCT4_20526341_ChIP-Seq_ESCs_Human1.05153969
84CEBPB_22108803_ChIP-Seq_LS180_Human1.04202881
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03944132
86REST_21632747_ChIP-Seq_MESCs_Mouse1.03871900
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.03590193
88FOXH1_21741376_ChIP-Seq_ESCs_Human1.03558109
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03499718
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02145079
91ETV1_20927104_ChIP-Seq_GIST48_Human1.01967259
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.01559862
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00805405
94ERA_21632823_ChIP-Seq_H3396_Human1.00061933
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00018064
96MYC_19829295_ChIP-Seq_ESCs_Human0.99987552
97HTT_18923047_ChIP-ChIP_STHdh_Human0.99628896
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98781248
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98003125
100OCT1_27270436_Chip-Seq_PROSTATE_Human0.97330990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.91790551
2MP0002876_abnormal_thyroid_physiology4.48066908
3MP0003195_calcinosis3.39660541
4MP0005551_abnormal_eye_electrophysiolog2.68102485
5MP0002837_dystrophic_cardiac_calcinosis2.60976742
6MP0008875_abnormal_xenobiotic_pharmacok2.59498341
7MP0005410_abnormal_fertilization2.57559810
8MP0003646_muscle_fatigue2.48008057
9MP0001968_abnormal_touch/_nociception2.45552073
10MP0005360_urolithiasis2.45292329
11MP0005646_abnormal_pituitary_gland2.39587747
12MP0001501_abnormal_sleep_pattern2.35008155
13MP0008877_abnormal_DNA_methylation2.20237635
14MP0004043_abnormal_pH_regulation2.13108271
15MP0003878_abnormal_ear_physiology2.11426639
16MP0005377_hearing/vestibular/ear_phenot2.11426639
17MP0009278_abnormal_bone_marrow2.08358968
18MP0009046_muscle_twitch1.96908515
19MP0002653_abnormal_ependyma_morphology1.78395285
20MP0003045_fibrosis1.76655818
21MP0005645_abnormal_hypothalamus_physiol1.74736469
22MP0003879_abnormal_hair_cell1.68336827
23MP0000678_abnormal_parathyroid_gland1.65142243
24MP0005670_abnormal_white_adipose1.61217920
25MP0003698_abnormal_male_reproductive1.59620209
26MP0005085_abnormal_gallbladder_physiolo1.50550617
27MP0001929_abnormal_gametogenesis1.49660651
28MP0003950_abnormal_plasma_membrane1.47055824
29MP0008872_abnormal_physiological_respon1.46729982
30MP0009745_abnormal_behavioral_response1.45708774
31MP0001664_abnormal_digestion1.45572464
32MP0010329_abnormal_lipoprotein_level1.45097675
33MP0002139_abnormal_hepatobiliary_system1.44212568
34MP0003880_abnormal_central_pattern1.39200710
35MP0000681_abnormal_thyroid_gland1.38233671
36MP0005253_abnormal_eye_physiology1.37947746
37MP0003136_yellow_coat_color1.37035215
38MP0003183_abnormal_peptide_metabolism1.36630030
39MP0009764_decreased_sensitivity_to1.35390880
40MP0005365_abnormal_bile_salt1.33627937
41MP0004147_increased_porphyrin_level1.33015062
42MP0003718_maternal_effect1.31865888
43MP0002272_abnormal_nervous_system1.30759447
44MP0006072_abnormal_retinal_apoptosis1.29613222
45MP0002160_abnormal_reproductive_system1.25800064
46MP0003633_abnormal_nervous_system1.25174917
47MP0001486_abnormal_startle_reflex1.24595088
48MP0002138_abnormal_hepatobiliary_system1.24112930
49MP0002168_other_aberrant_phenotype1.21248109
50MP0002733_abnormal_thermal_nociception1.20665448
51MP0001485_abnormal_pinna_reflex1.19344867
52MP0003941_abnormal_skin_development1.18221328
53MP0005389_reproductive_system_phenotype1.15983150
54MP0006276_abnormal_autonomic_nervous1.14623328
55MP0000427_abnormal_hair_cycle1.14613664
56MP0001984_abnormal_olfaction1.13768500
57MP0005167_abnormal_blood-brain_barrier1.13366068
58MP0000569_abnormal_digit_pigmentation1.09892515
59MP0005395_other_phenotype1.08246231
60MP0000230_abnormal_systemic_arterial1.05423850
61MP0000015_abnormal_ear_pigmentation1.05101127
62MP0001970_abnormal_pain_threshold1.02599978
63MP0002229_neurodegeneration1.02406437
64MP0000383_abnormal_hair_follicle1.02197336
65MP0005332_abnormal_amino_acid1.01913041
66MP0006035_abnormal_mitochondrial_morpho1.01019158
67MP0002693_abnormal_pancreas_physiology1.00230423
68MP0002557_abnormal_social/conspecific_i0.97233814
69MP0005379_endocrine/exocrine_gland_phen0.96003312
70MP0001324_abnormal_eye_pigmentation0.95378965
71MP0001765_abnormal_ion_homeostasis0.94316822
72MP0003252_abnormal_bile_duct0.91804644
73MP0001764_abnormal_homeostasis0.91587324
74MP0005503_abnormal_tendon_morphology0.91563577
75MP0002210_abnormal_sex_determination0.91261384
76MP0005310_abnormal_salivary_gland0.90137493
77MP0002735_abnormal_chemical_nociception0.89786540
78MP0002249_abnormal_larynx_morphology0.88762591
79MP0002971_abnormal_brown_adipose0.87622660
80MP0004133_heterotaxia0.87176470
81MP0001545_abnormal_hematopoietic_system0.87166179
82MP0005397_hematopoietic_system_phenotyp0.87166179
83MP0003631_nervous_system_phenotype0.84543941
84MP0005195_abnormal_posterior_eye0.83866336
85MP0001270_distended_abdomen0.83016978
86MP0001919_abnormal_reproductive_system0.82867012
87MP0005636_abnormal_mineral_homeostasis0.81188994
88MP0002102_abnormal_ear_morphology0.80869671
89MP0003959_abnormal_lean_body0.80083338
90MP0002909_abnormal_adrenal_gland0.79882196
91MP0002572_abnormal_emotion/affect_behav0.79045106
92MP0008775_abnormal_heart_ventricle0.78341580
93MP0003638_abnormal_response/metabolism_0.77672522
94MP0010678_abnormal_skin_adnexa0.75771243
95MP0004215_abnormal_myocardial_fiber0.75431642
96MP0001756_abnormal_urination0.75332752
97MP0002938_white_spotting0.74634095
98MP0004019_abnormal_vitamin_homeostasis0.74265815
99MP0001963_abnormal_hearing_physiology0.73706245
100MP0005647_abnormal_sex_gland0.73527015

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)6.29373011
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.60290975
3Absent/shortened dynein arms (HP:0200106)5.60290975
4Abnormal respiratory epithelium morphology (HP:0012253)5.32963023
5Abnormal respiratory motile cilium morphology (HP:0005938)5.32963023
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.19595871
7Abnormal ciliary motility (HP:0012262)5.18203326
8Abnormal respiratory motile cilium physiology (HP:0012261)5.00291694
9Rhinitis (HP:0012384)4.36872633
10Pancreatic cysts (HP:0001737)3.95240983
11Pancreatic fibrosis (HP:0100732)3.73460699
12Intestinal atresia (HP:0011100)3.67374583
13Tubular atrophy (HP:0000092)3.66389875
14Nephronophthisis (HP:0000090)3.54963703
15Molar tooth sign on MRI (HP:0002419)3.51815709
16Abnormality of midbrain morphology (HP:0002418)3.51815709
17Pancreatic islet-cell hyperplasia (HP:0004510)3.44809157
18True hermaphroditism (HP:0010459)3.43891842
19Chronic hepatic failure (HP:0100626)3.40332512
20Large for gestational age (HP:0001520)3.33341791
21Volvulus (HP:0002580)3.30724810
22Gaze-evoked nystagmus (HP:0000640)3.18909836
23Abnormality of the renal medulla (HP:0100957)3.18508966
24Bronchiectasis (HP:0002110)3.17797856
25Attenuation of retinal blood vessels (HP:0007843)3.14434762
26Chronic bronchitis (HP:0004469)3.06271649
27Abnormality of macular pigmentation (HP:0008002)3.05829188
28Congenital stationary night blindness (HP:0007642)3.04748663
29Type II lissencephaly (HP:0007260)3.02003525
30Cystic liver disease (HP:0006706)2.97282916
31Amelogenesis imperfecta (HP:0000705)2.88682431
32Abnormality of the renal cortex (HP:0011035)2.88369857
33Abnormality of the aortic arch (HP:0012303)2.75187100
34Cerebellar dysplasia (HP:0007033)2.71030077
35Severe visual impairment (HP:0001141)2.67899253
36Decreased circulating renin level (HP:0003351)2.58975201
37Decreased central vision (HP:0007663)2.58474139
38Abnormal drinking behavior (HP:0030082)2.57238872
39Polydipsia (HP:0001959)2.57238872
40Broad alveolar ridges (HP:0000187)2.54073842
41Pendular nystagmus (HP:0012043)2.53885674
42Focal motor seizures (HP:0011153)2.52967416
43Bony spicule pigmentary retinopathy (HP:0007737)2.52669412
44Abnormal rod and cone electroretinograms (HP:0008323)2.50796345
45Agitation (HP:0000713)2.41674303
46Abolished electroretinogram (ERG) (HP:0000550)2.38159923
47Pigmentary retinal degeneration (HP:0001146)2.34816667
48Increased corneal curvature (HP:0100692)2.33424040
49Keratoconus (HP:0000563)2.33424040
50Medial flaring of the eyebrow (HP:0010747)2.21518158
51Thickened helices (HP:0000391)2.19329729
52Occipital encephalocele (HP:0002085)2.14445435
53Tubulointerstitial nephritis (HP:0001970)2.12397499
54Hyperkalemia (HP:0002153)2.11758458
55Progressive inability to walk (HP:0002505)2.10457394
56Abnormality of the pancreatic islet cells (HP:0006476)2.10035219
57Abnormality of endocrine pancreas physiology (HP:0012093)2.10035219
58Hyperventilation (HP:0002883)2.09803686
59Poor head control (HP:0002421)2.08444704
60Congenital hepatic fibrosis (HP:0002612)2.08168758
61Sclerocornea (HP:0000647)2.07678464
62Dialeptic seizures (HP:0011146)2.05266035
63Lissencephaly (HP:0001339)2.02768369
64Infertility (HP:0000789)2.02268570
65Oligodontia (HP:0000677)2.01643419
66Furrowed tongue (HP:0000221)2.01398483
67Polyuria (HP:0000103)2.00852918
68Inability to walk (HP:0002540)1.98856411
69Abnormality of the ileum (HP:0001549)1.98160628
70Male pseudohermaphroditism (HP:0000037)1.98015701
71Postaxial foot polydactyly (HP:0001830)1.96090981
72Central scotoma (HP:0000603)1.94957800
73Congenital sensorineural hearing impairment (HP:0008527)1.94242779
74Gastrointestinal atresia (HP:0002589)1.93940097
75Mesangial abnormality (HP:0001966)1.90653606
76Abnormal urine output (HP:0012590)1.90549733
77Abnormality of the vitreous humor (HP:0004327)1.90367307
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.90124706
79Tubulointerstitial abnormality (HP:0001969)1.88839974
80Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88541840
81Broad-based gait (HP:0002136)1.87132945
82Nasal polyposis (HP:0100582)1.87094987
83Cone-rod dystrophy (HP:0000548)1.85587811
84Retinitis pigmentosa (HP:0000510)1.84196466
85Abnormality of renal excretion (HP:0011036)1.82697764
86Anencephaly (HP:0002323)1.80008721
87Abnormality of dental color (HP:0011073)1.79813173
88Bile duct proliferation (HP:0001408)1.79623750
89Abnormal biliary tract physiology (HP:0012439)1.79623750
90Ketoacidosis (HP:0001993)1.79142663
91Absent speech (HP:0001344)1.76253766
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.75956232
93Optic nerve hypoplasia (HP:0000609)1.75578827
94Progressive cerebellar ataxia (HP:0002073)1.75174925
95Potter facies (HP:0002009)1.73659488
96Facial shape deformation (HP:0011334)1.73659488
97Scotoma (HP:0000575)1.71584851
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70612693
99Congenital primary aphakia (HP:0007707)1.70508622
100Focal seizures (HP:0007359)1.70367219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.04147876
2ADRBK26.77091312
3PINK13.64077301
4STK38L3.00388770
5ACVR1B2.88127825
6WNK42.30619730
7PNCK2.17830949
8LATS12.08799192
9BMPR1B2.06138129
10ZAK1.77924039
11MST41.76335286
12ADRBK11.72890149
13GRK11.71786250
14INSRR1.71306908
15MAPK151.71248197
16PRKD31.66690801
17STK381.50471682
18WNK31.44947598
19MAP4K21.38800685
20PTK2B1.38743867
21STK391.36786430
22STK31.33566537
23PRKCE1.33283327
24OXSR11.32129102
25PLK41.27378544
26PRKCG1.15950388
27AKT31.15143435
28DAPK21.13763472
29PLK21.06127749
30BRSK21.05069803
31FLT31.03968106
32MAPK130.95686051
33IRAK10.93657217
34TGFBR10.93256884
35TLK10.91311064
36PIK3CG0.87230684
37NEK20.86204351
38MAPKAPK30.80577061
39CAMK1G0.79746130
40FGFR20.79735090
41TAOK30.78743701
42ERN10.76330831
43MAPKAPK50.76285422
44MAP3K40.74783265
45PRKAA20.74613443
46NTRK30.73034301
47TRPM70.72970404
48MAPK110.72435994
49MUSK0.68806823
50NUAK10.68365225
51PRKCI0.66077014
52CASK0.60738431
53CSNK1A1L0.60391805
54SIK20.60312367
55BRD40.59571539
56TNIK0.59083965
57CAMK2A0.58964627
58MAP3K70.57365960
59MAP3K20.55531219
60BCR0.54830540
61MAP2K60.54563934
62TIE10.53839020
63TRIM280.52708068
64DYRK30.52575075
65TYRO30.50533429
66EIF2AK30.49948340
67ERBB20.48551610
68IRAK30.48181202
69OBSCN0.46957466
70PIK3CA0.46422166
71NME10.44731881
72FER0.44550371
73CSNK1G20.44333841
74PDK10.44044005
75PHKG10.41500488
76PHKG20.41500488
77CAMK10.39984362
78CSNK1G10.39480456
79PRKAA10.39343056
80PDPK10.38559019
81MELK0.38544265
82CSNK1G30.38542519
83SGK10.38221807
84MKNK20.35988003
85CSF1R0.35947583
86PRKACA0.34759332
87NLK0.34582633
88CSNK1A10.33679028
89PRKG10.33555880
90MAP2K20.33542738
91CSNK1D0.31316938
92TXK0.31075397
93PRKCA0.30081454
94MAP2K70.29444748
95NEK90.29400419
96PRKCQ0.29341626
97MAP2K10.28332650
98PAK30.27781802
99WNK10.27637218
100BRSK10.27577239

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.70029702
2Butanoate metabolism_Homo sapiens_hsa006502.63317198
3ABC transporters_Homo sapiens_hsa020102.54399481
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.52046512
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36874584
6Olfactory transduction_Homo sapiens_hsa047402.24592014
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20459139
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19902835
9Linoleic acid metabolism_Homo sapiens_hsa005912.19458657
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16670167
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14939899
12Sphingolipid metabolism_Homo sapiens_hsa006002.11428442
13Dorso-ventral axis formation_Homo sapiens_hsa043202.10933828
14Nitrogen metabolism_Homo sapiens_hsa009102.06924083
15Tryptophan metabolism_Homo sapiens_hsa003802.06038546
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03619414
17Chemical carcinogenesis_Homo sapiens_hsa052041.94618306
18Histidine metabolism_Homo sapiens_hsa003401.94383946
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88644725
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.86960948
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85427591
22Selenocompound metabolism_Homo sapiens_hsa004501.85100054
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76699628
24Retinol metabolism_Homo sapiens_hsa008301.69165503
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68609950
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63223588
27Taste transduction_Homo sapiens_hsa047421.59260223
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.52820841
29Caffeine metabolism_Homo sapiens_hsa002321.52776807
30Fatty acid degradation_Homo sapiens_hsa000711.45595789
31Ovarian steroidogenesis_Homo sapiens_hsa049131.43138669
32Nicotine addiction_Homo sapiens_hsa050331.42329446
33Morphine addiction_Homo sapiens_hsa050321.42235513
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40088221
35Fatty acid biosynthesis_Homo sapiens_hsa000611.39182728
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37439570
37Glycerolipid metabolism_Homo sapiens_hsa005611.34358736
38Peroxisome_Homo sapiens_hsa041461.33523521
39beta-Alanine metabolism_Homo sapiens_hsa004101.27251622
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24937817
41Ether lipid metabolism_Homo sapiens_hsa005651.19941333
42Complement and coagulation cascades_Homo sapiens_hsa046101.19826428
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16880893
44Propanoate metabolism_Homo sapiens_hsa006401.13256481
45Fanconi anemia pathway_Homo sapiens_hsa034601.10274992
46Arachidonic acid metabolism_Homo sapiens_hsa005901.08129917
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.04948678
48Salivary secretion_Homo sapiens_hsa049700.97998677
49Tyrosine metabolism_Homo sapiens_hsa003500.96032589
50Starch and sucrose metabolism_Homo sapiens_hsa005000.95668825
51Fat digestion and absorption_Homo sapiens_hsa049750.91516780
52Basal transcription factors_Homo sapiens_hsa030220.90001026
53Sulfur metabolism_Homo sapiens_hsa009200.87643917
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.85977247
55Phenylalanine metabolism_Homo sapiens_hsa003600.84660506
56Calcium signaling pathway_Homo sapiens_hsa040200.84308213
57Serotonergic synapse_Homo sapiens_hsa047260.83363901
58Mineral absorption_Homo sapiens_hsa049780.79060092
59Insulin secretion_Homo sapiens_hsa049110.77308990
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76482491
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.74785736
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.74397265
63Homologous recombination_Homo sapiens_hsa034400.74266711
64Glutamatergic synapse_Homo sapiens_hsa047240.73336823
65Circadian entrainment_Homo sapiens_hsa047130.72599454
66Vitamin digestion and absorption_Homo sapiens_hsa049770.71165752
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68269174
68Metabolic pathways_Homo sapiens_hsa011000.66517497
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65837655
70Fatty acid metabolism_Homo sapiens_hsa012120.63506901
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62403573
72GABAergic synapse_Homo sapiens_hsa047270.62328185
73Glutathione metabolism_Homo sapiens_hsa004800.60745644
74Circadian rhythm_Homo sapiens_hsa047100.58790647
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58260309
76Arginine biosynthesis_Homo sapiens_hsa002200.56241476
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55823476
78Sulfur relay system_Homo sapiens_hsa041220.52631260
79PPAR signaling pathway_Homo sapiens_hsa033200.52131552
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51308689
81Arginine and proline metabolism_Homo sapiens_hsa003300.51281018
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.49076409
83Regulation of autophagy_Homo sapiens_hsa041400.47931810
84Bile secretion_Homo sapiens_hsa049760.44420624
85Type I diabetes mellitus_Homo sapiens_hsa049400.42542438
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42181173
87Purine metabolism_Homo sapiens_hsa002300.39141955
88Asthma_Homo sapiens_hsa053100.36483255
89Long-term depression_Homo sapiens_hsa047300.33729813
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30844758
91One carbon pool by folate_Homo sapiens_hsa006700.30242253
92Renin secretion_Homo sapiens_hsa049240.29910457
93Huntingtons disease_Homo sapiens_hsa050160.28694484
94Collecting duct acid secretion_Homo sapiens_hsa049660.24339070
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23826222
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22096728
97Pancreatic secretion_Homo sapiens_hsa049720.21138786
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21051997
99Graft-versus-host disease_Homo sapiens_hsa053320.20393481
100Oxytocin signaling pathway_Homo sapiens_hsa049210.20160963

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