CCDC168

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.00577978
2chromosome condensation (GO:0030261)8.47896961
3plasma membrane fusion (GO:0045026)8.27973356
4DNA packaging (GO:0006323)8.25418505
5protein targeting to Golgi (GO:0000042)8.03555644
6establishment of protein localization to Golgi (GO:0072600)7.89960108
7response to pheromone (GO:0019236)7.88882167
8microtubule depolymerization (GO:0007019)7.86395588
9spermatid development (GO:0007286)7.63793313
10retrograde transport, vesicle recycling within Golgi (GO:0000301)7.49872004
11single strand break repair (GO:0000012)7.27803586
12microtubule polymerization or depolymerization (GO:0031109)7.24876514
13protein polyglutamylation (GO:0018095)7.13100427
14multicellular organism reproduction (GO:0032504)7.12274814
15sperm-egg recognition (GO:0035036)7.11314246
16centriole replication (GO:0007099)7.04479194
17rRNA methylation (GO:0031167)6.83610049
18spermatid nucleus differentiation (GO:0007289)6.81256232
19reproduction (GO:0000003)6.46188904
20calcium ion-dependent exocytosis (GO:0017156)6.35917544
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.30749325
22spermatogenesis (GO:0007283)6.19975608
23male gamete generation (GO:0048232)6.18076007
24binding of sperm to zona pellucida (GO:0007339)6.12895518
25centriole assembly (GO:0098534)6.04893700
26axonemal dynein complex assembly (GO:0070286)6.02363472
27cell-cell recognition (GO:0009988)5.85771477
28phosphatidylethanolamine metabolic process (GO:0046337)5.82349358
29rRNA modification (GO:0000154)5.74769164
30protein localization to Golgi apparatus (GO:0034067)5.73557308
31regulation of centriole replication (GO:0046599)5.66357713
32gamete generation (GO:0007276)5.66197504
33sexual reproduction (GO:0019953)5.59252206
34regulation of Rab GTPase activity (GO:0032313)5.50792737
35positive regulation of Rab GTPase activity (GO:0032851)5.50792737
36seminiferous tubule development (GO:0072520)5.50559427
37microtubule severing (GO:0051013)5.48522362
38negative regulation of inclusion body assembly (GO:0090084)5.40471027
39cilium or flagellum-dependent cell motility (GO:0001539)5.28676974
40single fertilization (GO:0007338)5.13533283
41regulation of cilium movement (GO:0003352)4.96430776
42motile cilium assembly (GO:0044458)4.90854556
43regulation of transcription involved in cell fate commitment (GO:0060850)4.83571099
44RNA destabilization (GO:0050779)4.70141986
45musculoskeletal movement (GO:0050881)4.53494575
46multicellular organismal movement (GO:0050879)4.53494575
47multicellular organismal reproductive process (GO:0048609)4.52446829
48fertilization (GO:0009566)4.48184436
49cell wall macromolecule metabolic process (GO:0044036)4.43399215
50germ cell development (GO:0007281)4.38243948
51cellular ketone body metabolic process (GO:0046950)4.37563338
52epithelial cilium movement (GO:0003351)4.32971645
53cell wall macromolecule catabolic process (GO:0016998)4.26945912
54cellular process involved in reproduction in multicellular organism (GO:0022412)4.23683760
55microtubule nucleation (GO:0007020)4.15343558
56glomerular visceral epithelial cell development (GO:0072015)4.01897098
57nucleus organization (GO:0006997)3.94445680
58chromatin silencing (GO:0006342)3.87247383
59cilium movement (GO:0003341)3.84397058
60Golgi to endosome transport (GO:0006895)3.83974974
61ketone body metabolic process (GO:1902224)3.83908982
62glomerular epithelial cell development (GO:0072310)3.76689141
63regulation of inclusion body assembly (GO:0090083)3.76408936
64organic cation transport (GO:0015695)3.74086896
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62890226
66response to acidic pH (GO:0010447)3.30658720
67glycerol ether metabolic process (GO:0006662)3.28010865
68regulation of microtubule-based movement (GO:0060632)3.26888457
69cellular response to pH (GO:0071467)3.24523830
70coenzyme catabolic process (GO:0009109)3.22151608
71cerebral cortex neuron differentiation (GO:0021895)3.20404884
72negative regulation of Rho protein signal transduction (GO:0035024)3.20032734
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.16066710
74histone H3-K9 demethylation (GO:0033169)3.13831787
75intra-Golgi vesicle-mediated transport (GO:0006891)3.05173035
76membrane protein intracellular domain proteolysis (GO:0031293)3.04660864
77regulation of interleukin-13 production (GO:0032656)3.04181932
78homeostasis of number of cells within a tissue (GO:0048873)3.02893832
79ether metabolic process (GO:0018904)3.01542602
80regulation of phosphoprotein phosphatase activity (GO:0043666)3.01143247
81nuclear pore complex assembly (GO:0051292)3.00006153
82peptidyl-threonine dephosphorylation (GO:0035970)2.98592938
83centrosome duplication (GO:0051298)2.98175477
84multicellular organismal development (GO:0007275)2.96416669
85protein depolymerization (GO:0051261)2.93960946
86polyamine biosynthetic process (GO:0006596)2.91380793
87positive regulation of guanylate cyclase activity (GO:0031284)2.89941924
88vesicle transport along microtubule (GO:0047496)2.85674379
89cell recognition (GO:0008037)2.83133209
90mitotic G1 DNA damage checkpoint (GO:0031571)2.82617042
91detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.81908127
92ventricular system development (GO:0021591)2.79686950
93regulation of guanylate cyclase activity (GO:0031282)2.79453316
94axoneme assembly (GO:0035082)2.77865936
95male meiosis I (GO:0007141)2.73849507
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72932633
97protein-DNA complex disassembly (GO:0032986)2.69785217
98sperm motility (GO:0030317)11.8503742
99acrosome reaction (GO:0007340)11.0697054
100fusion of sperm to egg plasma membrane (GO:0007342)10.9551580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87615679
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82299195
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.14373963
4EZH2_22144423_ChIP-Seq_EOC_Human2.63916975
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50561572
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.50561572
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42525210
8IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.32596378
9CBP_20019798_ChIP-Seq_JUKART_Human2.32596378
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32113261
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22456783
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19703447
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.08230304
14FUS_26573619_Chip-Seq_HEK293_Human2.07292926
15DROSHA_22980978_ChIP-Seq_HELA_Human2.04615066
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80012224
17RAC3_21632823_ChIP-Seq_H3396_Human1.77252342
18ER_23166858_ChIP-Seq_MCF-7_Human1.76050140
19ERA_21632823_ChIP-Seq_H3396_Human1.74797044
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73864645
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.72207859
22NANOG_20526341_ChIP-Seq_ESCs_Human1.66308581
23EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.66083402
24SMAD4_21741376_ChIP-Seq_EPCs_Human1.62614208
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.62556604
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.61559201
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60419055
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60018389
29MYC_19829295_ChIP-Seq_ESCs_Human1.56904857
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.55623453
31ZNF274_21170338_ChIP-Seq_K562_Hela1.50151349
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.49707040
33TAF2_19829295_ChIP-Seq_ESCs_Human1.49112269
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48700907
35CTCF_27219007_Chip-Seq_Bcells_Human1.48484924
36AR_21572438_ChIP-Seq_LNCaP_Human1.46690561
37AR_25329375_ChIP-Seq_VCAP_Human1.46370040
38CBX2_22325352_ChIP-Seq_293T-Rex_Human1.45014710
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44565787
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42945158
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42413180
42OCT4_20526341_ChIP-Seq_ESCs_Human1.42170298
43HNFA_21074721_ChIP-Seq_CACO-2_Human1.41490814
44P300_19829295_ChIP-Seq_ESCs_Human1.41264492
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41224818
46RBPJ_21746931_ChIP-Seq_IB4_Human1.40800132
47TP53_18474530_ChIP-ChIP_U2OS_Human1.39660278
48ETV1_20927104_ChIP-Seq_GIST48_Human1.39352598
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37680041
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36489877
51SMC4_20622854_ChIP-Seq_HELA_Human1.35464350
52SMAD3_21741376_ChIP-Seq_ESCs_Human1.35437737
53NFYB_21822215_ChIP-Seq_K562_Human1.33900059
54TAF15_26573619_Chip-Seq_HEK293_Human1.33217842
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32970072
56ERG_20517297_ChIP-Seq_VCAP_Human1.32404117
57BCL6_27268052_Chip-Seq_Bcells_Human1.32392108
58TBL1_22424771_ChIP-Seq_293T_Human1.29087252
59CEBPB_22108803_ChIP-Seq_LS180_Human1.28893348
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28507302
61CTCF_20526341_ChIP-Seq_ESCs_Human1.27550920
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25247591
63STAT3_23295773_ChIP-Seq_U87_Human1.25118022
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24982785
65E2F1_20622854_ChIP-Seq_HELA_Human1.23680198
66TP63_22573176_ChIP-Seq_HFKS_Human1.23525437
67BCOR_27268052_Chip-Seq_Bcells_Human1.22689551
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22006374
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.22000502
70PHF8_20622854_ChIP-Seq_HELA_Human1.21983398
71PHF8_20622853_ChIP-Seq_HELA_Human1.21377924
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20807123
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.19878239
74P68_20966046_ChIP-Seq_HELA_Human1.19089541
75SMAD4_21799915_ChIP-Seq_A2780_Human1.18787122
76RUNX2_22187159_ChIP-Seq_PCA_Human1.15197029
77GATA6_21074721_ChIP-Seq_CACO-2_Human1.14213655
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13824897
79P300_27268052_Chip-Seq_Bcells_Human1.13752304
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12903159
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.12122881
82NFYA_21822215_ChIP-Seq_K562_Human1.11414908
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11327565
84NANOG_19829295_ChIP-Seq_ESCs_Human1.09198432
85SOX2_19829295_ChIP-Seq_ESCs_Human1.09198432
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08705077
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.07819313
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07780259
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07724315
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07487937
91P53_21459846_ChIP-Seq_SAOS-2_Human1.07340479
92SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07255914
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.07094573
94SMRT_27268052_Chip-Seq_Bcells_Human1.05977527
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04851560
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03791562
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.02117155
98VDR_22108803_ChIP-Seq_LS180_Human1.01820424
99GBX2_23144817_ChIP-Seq_PC3_Human1.01281666
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00367595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.94564456
2MP0003878_abnormal_ear_physiology5.94564456
3MP0005670_abnormal_white_adipose4.71047059
4MP0003698_abnormal_male_reproductive4.23718175
5MP0001929_abnormal_gametogenesis3.68493119
6MP0001348_abnormal_lacrimal_gland3.53689937
7MP0002161_abnormal_fertility/fecundity2.31381299
8MP0003646_muscle_fatigue2.29321691
9MP0003718_maternal_effect2.25711618
10MP0005379_endocrine/exocrine_gland_phen2.02017575
11MP0005410_abnormal_fertilization11.6065813
12MP0000678_abnormal_parathyroid_gland1.97218539
13MP0001485_abnormal_pinna_reflex1.94827843
14MP0005451_abnormal_body_composition1.84457453
15MP0002822_catalepsy1.84376380
16MP0002132_abnormal_respiratory_system1.79588916
17MP0005310_abnormal_salivary_gland1.72170293
18MP0001486_abnormal_startle_reflex1.68281250
19MP0002210_abnormal_sex_determination1.66277183
20MP0003879_abnormal_hair_cell1.62279227
21MP0005423_abnormal_somatic_nervous1.48429753
22MP0003011_delayed_dark_adaptation1.34750889
23MP0001145_abnormal_male_reproductive1.32990831
24MP0004742_abnormal_vestibular_system1.29660520
25MP0002282_abnormal_trachea_morphology1.29182561
26MP0000653_abnormal_sex_gland1.28713403
27MP0004859_abnormal_synaptic_plasticity1.24384814
28MP0002234_abnormal_pharynx_morphology1.24145795
29MP0001968_abnormal_touch/_nociception1.21268385
30MP0002735_abnormal_chemical_nociception1.20084299
31MP0001963_abnormal_hearing_physiology1.19903178
32MP0009053_abnormal_anal_canal1.17270021
33MP0005551_abnormal_eye_electrophysiolog1.13617881
34MP0001765_abnormal_ion_homeostasis1.12875134
35MP0002138_abnormal_hepatobiliary_system1.10136624
36MP0002249_abnormal_larynx_morphology1.09918143
37MP0009697_abnormal_copulation1.04321746
38MP0009115_abnormal_fat_cell1.01280299
39MP0005395_other_phenotype0.99575597
40MP0002127_abnormal_cardiovascular_syste0.96868194
41MP0000026_abnormal_inner_ear0.96487727
42MP0005253_abnormal_eye_physiology0.96216804
43MP0004510_myositis0.93809215
44MP0002229_neurodegeneration0.91725506
45MP0000534_abnormal_ureter_morphology0.91441412
46MP0005167_abnormal_blood-brain_barrier0.90040881
47MP0008877_abnormal_DNA_methylation0.87566551
48MP0002067_abnormal_sensory_capabilities0.85815989
49MP0001984_abnormal_olfaction0.85047867
50MP0005666_abnormal_adipose_tissue0.83300223
51MP0000955_abnormal_spinal_cord0.83055472
52MP0001905_abnormal_dopamine_level0.82728147
53MP0001501_abnormal_sleep_pattern0.80206844
54MP0008569_lethality_at_weaning0.78287842
55MP0002733_abnormal_thermal_nociception0.73559469
56MP0005248_abnormal_Harderian_gland0.73144895
57MP0004085_abnormal_heartbeat0.71450174
58MP0002572_abnormal_emotion/affect_behav0.70797072
59MP0002557_abnormal_social/conspecific_i0.70183531
60MP0009745_abnormal_behavioral_response0.67759947
61MP0004036_abnormal_muscle_relaxation0.67253735
62MP0001666_abnormal_nutrient_absorption0.66665583
63MP0005375_adipose_tissue_phenotype0.62921326
64MP0000230_abnormal_systemic_arterial0.61687357
65MP0004084_abnormal_cardiac_muscle0.58651964
66MP0001440_abnormal_grooming_behavior0.58144106
67MP0005636_abnormal_mineral_homeostasis0.56825608
68MP0004233_abnormal_muscle_weight0.55725889
69MP0002272_abnormal_nervous_system0.53904050
70MP0005083_abnormal_biliary_tract0.52961814
71MP0000681_abnormal_thyroid_gland0.52722464
72MP0003950_abnormal_plasma_membrane0.52698712
73MP0001970_abnormal_pain_threshold0.52483880
74MP0005535_abnormal_body_temperature0.51804715
75MP0008961_abnormal_basal_metabolism0.51351887
76MP0004484_altered_response_of0.49849613
77MP0002734_abnormal_mechanical_nocicepti0.49843667
78MP0003631_nervous_system_phenotype0.49827616
79MP0010329_abnormal_lipoprotein_level0.48418272
80MP0003137_abnormal_impulse_conducting0.46577295
81MP0000003_abnormal_adipose_tissue0.45401693
82MP0009764_decreased_sensitivity_to0.43180172
83MP0000249_abnormal_blood_vessel0.43140849
84MP0003635_abnormal_synaptic_transmissio0.42521230
85MP0000049_abnormal_middle_ear0.42386701
86MP0003077_abnormal_cell_cycle0.41896763
87MP0003633_abnormal_nervous_system0.41260474
88MP0003632_abnormal_nervous_system0.41145846
89MP0001545_abnormal_hematopoietic_system0.40876952
90MP0005397_hematopoietic_system_phenotyp0.40876952
91MP0005595_abnormal_vascular_smooth0.39457640
92MP0001879_abnormal_lymphatic_vessel0.39430037
93MP0005391_vision/eye_phenotype0.38750589
94MP0005332_abnormal_amino_acid0.38480581
95MP0008995_early_reproductive_senescence0.34352352
96MP0000470_abnormal_stomach_morphology0.34264039
97MP0005367_renal/urinary_system_phenotyp0.33733197
98MP0000516_abnormal_urinary_system0.33733197
99MP0009046_muscle_twitch0.33672134
100MP0002928_abnormal_bile_duct0.33558132

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.14141927
2Absent/shortened dynein arms (HP:0200106)5.96208743
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.96208743
4Asymmetric septal hypertrophy (HP:0001670)5.95230232
5Tubulointerstitial nephritis (HP:0001970)5.80610996
6Chronic hepatic failure (HP:0100626)5.57564759
7Attenuation of retinal blood vessels (HP:0007843)4.80453887
8Bony spicule pigmentary retinopathy (HP:0007737)4.74398572
9Abnormal ciliary motility (HP:0012262)4.63078255
10Abnormal respiratory motile cilium physiology (HP:0012261)4.56384421
11Hyperkalemia (HP:0002153)4.48831610
12Male infertility (HP:0003251)4.47339818
13Resting tremor (HP:0002322)4.46633192
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.30958489
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20379642
16Cone-rod dystrophy (HP:0000548)4.17405327
17Abnormal respiratory motile cilium morphology (HP:0005938)4.16538152
18Abnormal respiratory epithelium morphology (HP:0012253)4.16538152
19Bell-shaped thorax (HP:0001591)4.15624818
20Abnormality of macular pigmentation (HP:0008002)4.11363067
21Infertility (HP:0000789)4.01603320
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.94848195
23Nasal polyposis (HP:0100582)3.89089105
24Impulsivity (HP:0100710)3.84533604
25Facial shape deformation (HP:0011334)3.71758763
26Potter facies (HP:0002009)3.71758763
27Hypoplastic ischia (HP:0003175)3.61962851
28Enlarged epiphyses (HP:0010580)3.61955608
29Hypoplasia of the thymus (HP:0000778)3.52925794
30Postural instability (HP:0002172)3.49907183
31Hypoalphalipoproteinemia (HP:0003233)3.33268318
32Progressive cerebellar ataxia (HP:0002073)3.32935430
33Abnormal rod and cone electroretinograms (HP:0008323)3.30553604
34Abnormality of the ischium (HP:0003174)3.26322535
35Amelogenesis imperfecta (HP:0000705)3.24544567
36Menstrual irregularities (HP:0000858)3.12416260
37Abnormality of the nasal mucosa (HP:0000433)3.10605957
38Portal hypertension (HP:0001409)3.08969555
39Nephronophthisis (HP:0000090)3.05227956
40Progressive sensorineural hearing impairment (HP:0000408)3.04006001
41Abnormality of dental color (HP:0011073)3.02327069
42Tubulointerstitial abnormality (HP:0001969)2.87399792
43Truncal obesity (HP:0001956)2.86982765
44Abnormal spermatogenesis (HP:0008669)2.84425712
45Abnormality of the hepatic vasculature (HP:0006707)2.83663454
46Renovascular hypertension (HP:0100817)2.82231141
47Stage 5 chronic kidney disease (HP:0003774)2.82170167
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72523658
49Rhinitis (HP:0012384)2.72272949
50Abnormal urine output (HP:0012590)2.69535560
51Insulin-resistant diabetes mellitus (HP:0000831)2.69362483
52Abnormality of the costochondral junction (HP:0000919)2.64585383
53Abnormality of the renal medulla (HP:0100957)2.61953778
54Abnormality of potassium homeostasis (HP:0011042)2.55381492
55Polydipsia (HP:0001959)2.51779181
56Abnormal drinking behavior (HP:0030082)2.51779181
57Generalized aminoaciduria (HP:0002909)2.47066837
58Azoospermia (HP:0000027)2.44710921
59Intellectual disability, moderate (HP:0002342)2.37625448
60Abnormality of renal excretion (HP:0011036)2.29289691
61Unilateral renal agenesis (HP:0000122)2.25598951
62Chronic bronchitis (HP:0004469)2.22175930
63Polyuria (HP:0000103)2.21474067
64Ventricular tachycardia (HP:0004756)2.21154184
65Congenital sensorineural hearing impairment (HP:0008527)2.14955315
66Widely patent fontanelles and sutures (HP:0004492)2.07427149
67Abnormality of the aortic arch (HP:0012303)2.06525932
68Hyperuricemia (HP:0002149)2.06380479
69Increased purine levels (HP:0004368)2.06380479
70Bronchiectasis (HP:0002110)2.05611115
71Epiphyseal dysplasia (HP:0002656)2.05219679
72Hypophosphatemic rickets (HP:0004912)2.04996395
73Congenital malformation of the right heart (HP:0011723)2.01239805
74Double outlet right ventricle (HP:0001719)2.01239805
75Recurrent pneumonia (HP:0006532)2.00322804
76Renal dysplasia (HP:0000110)1.99025272
77Tubular atrophy (HP:0000092)1.94688104
78Focal segmental glomerulosclerosis (HP:0000097)1.91768152
79Subcapsular cataract (HP:0000523)1.87702755
80Progressive hearing impairment (HP:0001730)1.87058078
81Decreased central vision (HP:0007663)1.86463241
82Osteomalacia (HP:0002749)1.85677494
83Sandal gap (HP:0001852)1.85531320
84Myokymia (HP:0002411)1.80903390
85Bradycardia (HP:0001662)1.78193258
86Hypolipoproteinemia (HP:0010981)1.77969812
87Hyponatremia (HP:0002902)1.77067918
88Photophobia (HP:0000613)1.76326068
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.76046225
90Abnormality of the parathyroid morphology (HP:0011766)1.75257701
91Occipital encephalocele (HP:0002085)1.74964410
92Abnormality of the pubic bones (HP:0003172)1.72689737
93Abnormality of chloride homeostasis (HP:0011422)1.72039993
94Optic nerve hypoplasia (HP:0000609)1.70274212
95Underdeveloped nasal alae (HP:0000430)1.67208472
96Absent epiphyses (HP:0010577)1.66781201
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66781201
98Mixed hearing impairment (HP:0000410)1.64766835
99Recurrent corneal erosions (HP:0000495)1.64709008
100Flattened epiphyses (HP:0003071)1.63767752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.51743255
2TESK14.76530616
3INSRR4.39467423
4DDR24.25699185
5BRD43.95054632
6PLK23.60208599
7PNCK2.84531930
8PIK3CG2.62582710
9STK382.59385574
10STK38L2.39452891
11CAMK1G2.36598426
12MAP4K22.09163182
13MAPK152.00564590
14CDK121.99987594
15PRKD31.79944981
16MST1R1.52548096
17PDK11.50973461
18PDPK11.47798313
19WNK11.45446733
20FRK1.34481306
21PTK2B1.27796151
22TYRO31.27575700
23NEK61.20643825
24CDK71.14684211
25CAMK1D0.95631182
26AKT30.94613886
27DYRK1B0.89522924
28MAP3K90.89437561
29PRKG20.85420222
30SIK20.83384970
31KSR20.78540222
32MAP3K110.67040379
33LATS20.64929183
34PRKAA20.64636341
35MUSK0.64340406
36PRKG10.63168556
37NTRK30.61999481
38RPS6KA20.61129075
39LATS10.60935452
40BRAF0.57568083
41CAMK10.56823155
42TIE10.50632484
43BMPR1B0.50485913
44ADRBK20.49126294
45MAP2K20.48227558
46RPS6KA10.47749842
47WNK40.45922630
48MARK10.44938609
49JAK30.42124614
50UHMK10.41906349
51PINK10.41656763
52STK390.40340830
53PRKCG0.39677576
54CDK30.39640417
55GSK3B0.38645819
56MAPK10.38601255
57RIPK40.38492227
58CDK20.38019628
59ROCK10.37817266
60CDK10.37278272
61CAMK40.37177360
62SGK4940.35519842
63SGK2230.35519842
64MAP3K20.35393897
65TESK20.34917034
66MTOR0.30886686
67RPS6KA60.30803327
68RPS6KC10.29614360
69RPS6KL10.29614360
70PRKCB0.27095937
71MAPK80.26481128
72ACVR1B0.26409635
73OXSR10.25885701
74MAPK110.24888291
75SGK10.24002003
76BRSK10.23999562
77BRSK20.23364690
78CHEK10.23323988
79ZAK0.23322178
80MAP3K80.22583171
81PRKCZ0.22563026
82MARK20.20799416
83MAPK140.20658891
84MAP3K10.19640135
85NUAK10.17950505
86PRKAA10.17728548
87ARAF0.16523758
88PKN10.16144659
89MARK30.15978726
90CDK40.15896644
91MAP3K40.14474136
92MAPK100.14347282
93SGK20.14177825
94PRKACB0.13779754
95AKT10.13717515
96PRKCE0.12432859
97BLK0.12323120
98RIPK10.11065312
99MAP3K70.09942479
100MET0.09939840

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.40881342
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.83002479
3Olfactory transduction_Homo sapiens_hsa047404.14100793
4Butanoate metabolism_Homo sapiens_hsa006502.26031767
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.07543992
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02340553
7Taste transduction_Homo sapiens_hsa047421.97243618
8Dorso-ventral axis formation_Homo sapiens_hsa043201.95162937
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66707873
10Fatty acid degradation_Homo sapiens_hsa000711.64642047
11Type II diabetes mellitus_Homo sapiens_hsa049301.64257584
12RNA transport_Homo sapiens_hsa030131.61131572
13Phototransduction_Homo sapiens_hsa047441.56981048
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40752597
15Fatty acid metabolism_Homo sapiens_hsa012121.37376712
16ABC transporters_Homo sapiens_hsa020101.35720066
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34627736
18Type I diabetes mellitus_Homo sapiens_hsa049401.31541940
19Phenylalanine metabolism_Homo sapiens_hsa003601.30619574
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.29030227
21Allograft rejection_Homo sapiens_hsa053301.26987144
22Morphine addiction_Homo sapiens_hsa050321.26007094
23Protein digestion and absorption_Homo sapiens_hsa049741.20457207
24Salivary secretion_Homo sapiens_hsa049701.18175687
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.17243386
26Nicotine addiction_Homo sapiens_hsa050331.16487795
27Autoimmune thyroid disease_Homo sapiens_hsa053201.16098438
28Graft-versus-host disease_Homo sapiens_hsa053321.16080451
29Calcium signaling pathway_Homo sapiens_hsa040201.12634233
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10920229
31Inositol phosphate metabolism_Homo sapiens_hsa005621.08329819
32Circadian entrainment_Homo sapiens_hsa047131.06302994
33Synaptic vesicle cycle_Homo sapiens_hsa047211.05461272
34PPAR signaling pathway_Homo sapiens_hsa033201.02249377
35Antigen processing and presentation_Homo sapiens_hsa046121.02033657
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99914068
37Glutamatergic synapse_Homo sapiens_hsa047240.96076919
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94451538
39cAMP signaling pathway_Homo sapiens_hsa040240.94119473
40Arginine biosynthesis_Homo sapiens_hsa002200.92211892
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91187615
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89444399
43Selenocompound metabolism_Homo sapiens_hsa004500.88183169
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86715885
45Nitrogen metabolism_Homo sapiens_hsa009100.85764265
46Fat digestion and absorption_Homo sapiens_hsa049750.85516710
47Endocytosis_Homo sapiens_hsa041440.83740174
48Arginine and proline metabolism_Homo sapiens_hsa003300.83525153
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81091192
50Glycerolipid metabolism_Homo sapiens_hsa005610.79272367
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78633421
52Gastric acid secretion_Homo sapiens_hsa049710.77078632
53Cardiac muscle contraction_Homo sapiens_hsa042600.74984291
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74382415
55Renin secretion_Homo sapiens_hsa049240.73652301
56Influenza A_Homo sapiens_hsa051640.72833903
57Viral myocarditis_Homo sapiens_hsa054160.72379630
58Hedgehog signaling pathway_Homo sapiens_hsa043400.71954935
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71742405
60Serotonergic synapse_Homo sapiens_hsa047260.70420875
61Renin-angiotensin system_Homo sapiens_hsa046140.69567101
62Retinol metabolism_Homo sapiens_hsa008300.67925500
63Bile secretion_Homo sapiens_hsa049760.67271189
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.66845264
65Oocyte meiosis_Homo sapiens_hsa041140.66065260
66VEGF signaling pathway_Homo sapiens_hsa043700.64215996
67GABAergic synapse_Homo sapiens_hsa047270.60636149
68Cholinergic synapse_Homo sapiens_hsa047250.59478773
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58794751
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.58443648
71Pancreatic secretion_Homo sapiens_hsa049720.57925713
72Estrogen signaling pathway_Homo sapiens_hsa049150.55151492
73Insulin secretion_Homo sapiens_hsa049110.54854604
74Tyrosine metabolism_Homo sapiens_hsa003500.54290676
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52952812
76Purine metabolism_Homo sapiens_hsa002300.51675239
77Basal transcription factors_Homo sapiens_hsa030220.48591939
78MAPK signaling pathway_Homo sapiens_hsa040100.44393775
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44346362
80Linoleic acid metabolism_Homo sapiens_hsa005910.42871333
81ECM-receptor interaction_Homo sapiens_hsa045120.42377466
82Oxytocin signaling pathway_Homo sapiens_hsa049210.42149290
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.41041585
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41030358
85Long-term potentiation_Homo sapiens_hsa047200.38939857
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34097407
87Amphetamine addiction_Homo sapiens_hsa050310.31280331
88Mineral absorption_Homo sapiens_hsa049780.31203489
89Fanconi anemia pathway_Homo sapiens_hsa034600.30857252
90Tight junction_Homo sapiens_hsa045300.28846087
91Chemical carcinogenesis_Homo sapiens_hsa052040.28709172
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28422898
93Tryptophan metabolism_Homo sapiens_hsa003800.27988660
94Acute myeloid leukemia_Homo sapiens_hsa052210.26805532
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25040908
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24691631
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24280471
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23499741
99Prolactin signaling pathway_Homo sapiens_hsa049170.22010612
100mRNA surveillance pathway_Homo sapiens_hsa030150.18763512

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