CCDC170

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.69306346
2GTP biosynthetic process (GO:0006183)9.49376109
3epithelial cilium movement (GO:0003351)9.23473379
4nucleoside diphosphate phosphorylation (GO:0006165)8.66990821
5UTP biosynthetic process (GO:0006228)8.27097755
6motile cilium assembly (GO:0044458)7.35782696
7UTP metabolic process (GO:0046051)7.28465223
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.05910212
9left/right axis specification (GO:0070986)6.88918754
10left/right pattern formation (GO:0060972)6.53806076
11guanosine-containing compound biosynthetic process (GO:1901070)6.45010805
12regulation of female receptivity (GO:0045924)6.27490590
13ventricular system development (GO:0021591)6.17546531
14intraciliary transport (GO:0042073)6.01874310
15CTP metabolic process (GO:0046036)5.97885802
16CTP biosynthetic process (GO:0006241)5.97885802
17cilium organization (GO:0044782)5.80393865
18microtubule bundle formation (GO:0001578)5.55300015
19sensory perception of smell (GO:0007608)5.45778115
20cilium assembly (GO:0042384)5.43178108
21female mating behavior (GO:0060180)5.34312331
22pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)5.31647697
23otic vesicle formation (GO:0030916)5.20946872
24primary alcohol catabolic process (GO:0034310)4.85694655
25nucleotide phosphorylation (GO:0046939)4.81130893
26pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.76138926
27pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.71493031
28response to xenobiotic stimulus (GO:0009410)4.70493430
29cilium morphogenesis (GO:0060271)4.66075434
30pyrimidine-containing compound transmembrane transport (GO:0072531)4.65975190
31cellular component assembly involved in morphogenesis (GO:0010927)4.46151956
32protein localization to cilium (GO:0061512)4.44392523
33negative regulation of T cell differentiation in thymus (GO:0033085)4.41788767
34regulation of microtubule-based movement (GO:0060632)4.40993443
35vitamin transmembrane transport (GO:0035461)4.31026796
36regulation of germinal center formation (GO:0002634)4.23339442
37ethanol metabolic process (GO:0006067)4.08461905
38daunorubicin metabolic process (GO:0044597)4.07742341
39polyketide metabolic process (GO:0030638)4.07742341
40doxorubicin metabolic process (GO:0044598)4.07742341
41regulation of pigment cell differentiation (GO:0050932)4.05342934
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.01369010
43nucleoside diphosphate metabolic process (GO:0009132)3.96941019
44tolerance induction (GO:0002507)3.92223285
45cell projection assembly (GO:0030031)3.87809359
46diterpenoid biosynthetic process (GO:0016102)3.87341148
47positive regulation of developmental pigmentation (GO:0048087)3.85906341
48phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.83673689
49regulation of mononuclear cell migration (GO:0071675)3.70403596
50ADP metabolic process (GO:0046031)3.69601243
51determination of left/right symmetry (GO:0007368)3.65067668
52microtubule-based movement (GO:0007018)3.62657901
53male meiosis I (GO:0007141)3.54903221
54cytoplasmic microtubule organization (GO:0031122)3.53735238
55brain morphogenesis (GO:0048854)3.51104248
56pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.50158852
57regulation of cilium movement (GO:0003352)3.48812937
58determination of bilateral symmetry (GO:0009855)3.46863146
59specification of symmetry (GO:0009799)3.44719024
60limb bud formation (GO:0060174)3.40744086
61lateral ventricle development (GO:0021670)3.39197687
62keratinocyte development (GO:0003334)3.37927257
63negative regulation of B cell mediated immunity (GO:0002713)3.36487538
64negative regulation of immunoglobulin mediated immune response (GO:0002890)3.36487538
65pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.35587481
66exogenous drug catabolic process (GO:0042738)3.32257893
67glomerular epithelial cell development (GO:0072310)3.30373326
68meiotic cell cycle (GO:0051321)3.27179748
69regulation of interleukin-5 production (GO:0032674)3.24201851
70lung epithelium development (GO:0060428)3.19829879
71sensory perception of chemical stimulus (GO:0007606)3.18577362
72multicellular organismal aging (GO:0010259)3.13954349
73retinoic acid metabolic process (GO:0042573)3.11212938
74deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.10529358
75centriole assembly (GO:0098534)3.02979778
76microtubule severing (GO:0051013)3.00397355
77sperm motility (GO:0030317)2.91734229
78ethanol oxidation (GO:0006069)2.91423706
79meiosis I (GO:0007127)2.91105210
80pyrimidine nucleotide biosynthetic process (GO:0006221)2.90911807
81negative regulation of T cell receptor signaling pathway (GO:0050860)2.90778102
82regulation of male gonad development (GO:2000018)2.89162195
83smoothened signaling pathway (GO:0007224)2.89019962
84pyrimidine ribonucleotide metabolic process (GO:0009218)2.88647845
85superoxide anion generation (GO:0042554)2.86525849
86intestinal epithelial cell development (GO:0060576)2.86122835
87terpenoid biosynthetic process (GO:0016114)2.85918586
88drug catabolic process (GO:0042737)2.85114194
89positive regulation of protein homooligomerization (GO:0032464)2.83116855
90retinal cone cell development (GO:0046549)2.80269966
91regulation of interleukin-13 production (GO:0032656)2.79683695
92multicellular organism reproduction (GO:0032504)2.79521829
93negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.79068683
94positive regulation of male gonad development (GO:2000020)2.78670488
95rRNA catabolic process (GO:0016075)2.76805458
96regulation of macrophage chemotaxis (GO:0010758)2.76556037
97protein-chromophore linkage (GO:0018298)2.75469277
98phenol-containing compound catabolic process (GO:0019336)2.75068590
99embryonic camera-type eye development (GO:0031076)2.74817630
100aminoglycoside antibiotic metabolic process (GO:0030647)2.73863844
101positive regulation of smoothened signaling pathway (GO:0045880)2.72724692
102pyrimidine ribonucleoside metabolic process (GO:0046131)2.71451150
103behavioral response to nicotine (GO:0035095)2.70717928
104multicellular organismal reproductive behavior (GO:0033057)2.69884892
105cornea development in camera-type eye (GO:0061303)2.68871346
106regulation of development, heterochronic (GO:0040034)2.68297250
107regulation of autophagic vacuole assembly (GO:2000785)2.67652104
108neurotransmitter metabolic process (GO:0042133)2.66187670
109cellular response to gamma radiation (GO:0071480)2.63646876
110retinol metabolic process (GO:0042572)2.63070841
111pyrimidine nucleoside biosynthetic process (GO:0046134)2.61746331
112protein polyglutamylation (GO:0018095)2.59706755
113lateral sprouting from an epithelium (GO:0060601)2.58839849
114indolalkylamine metabolic process (GO:0006586)2.58737486
115transmission of nerve impulse (GO:0019226)2.57746686
116O-glycan processing (GO:0016266)2.57672096
117positive regulation of meiosis (GO:0045836)2.55969374
118benzene-containing compound metabolic process (GO:0042537)2.55367359
119energy homeostasis (GO:0097009)2.54693085
120hydrogen peroxide biosynthetic process (GO:0050665)2.51684786
121photoreceptor cell differentiation (GO:0046530)2.51494407
122eye photoreceptor cell differentiation (GO:0001754)2.51494407
123regulation of meiosis I (GO:0060631)2.49201218
124phosphatidylcholine biosynthetic process (GO:0006656)2.48950494
125positive regulation of cellular amide metabolic process (GO:0034250)2.48630949
126glutathione derivative metabolic process (GO:1901685)2.48544661
127glutathione derivative biosynthetic process (GO:1901687)2.48544661
128positive regulation of meiotic cell cycle (GO:0051446)2.47930695
129piRNA metabolic process (GO:0034587)2.47869722
130sperm capacitation (GO:0048240)2.47314665
131negative regulation of myoblast differentiation (GO:0045662)2.46228129
132positive regulation of tolerance induction (GO:0002645)2.45897004
133adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.45315476
134pyrimidine-containing compound biosynthetic process (GO:0072528)2.43997554
135primary alcohol metabolic process (GO:0034308)2.43526352
136regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.41093015
137fucose catabolic process (GO:0019317)2.41027018
138L-fucose metabolic process (GO:0042354)2.41027018
139L-fucose catabolic process (GO:0042355)2.41027018
140negative regulation of systemic arterial blood pressure (GO:0003085)2.40495982
141one-carbon compound transport (GO:0019755)2.39169620
142regulation of cilium assembly (GO:1902017)2.39053494
143centriole replication (GO:0007099)2.38807426
144kidney morphogenesis (GO:0060993)2.38657012
145regulation of smoothened signaling pathway (GO:0008589)2.38067143
146organelle assembly (GO:0070925)2.35461680
147regulation of female gonad development (GO:2000194)2.34456613
148extracellular negative regulation of signal transduction (GO:1900116)2.33910267
149extracellular regulation of signal transduction (GO:1900115)2.33910267
150intra-S DNA damage checkpoint (GO:0031573)2.33407170
151indole-containing compound catabolic process (GO:0042436)2.33058990
152indolalkylamine catabolic process (GO:0046218)2.33058990
153tryptophan catabolic process (GO:0006569)2.33058990
154detection of calcium ion (GO:0005513)2.33025913
155regulation of mesenchymal cell apoptotic process (GO:2001053)2.32570684
156negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.31505466
157male meiosis (GO:0007140)2.30976232
158sulfation (GO:0051923)2.30572603
159relaxation of smooth muscle (GO:0044557)2.30206621
160regulation of memory T cell differentiation (GO:0043380)2.29323717
161negative regulation of humoral immune response (GO:0002921)2.29083004
162purine ribonucleoside diphosphate metabolic process (GO:0009179)2.29078894
163purine nucleoside diphosphate metabolic process (GO:0009135)2.29078894
164excretion (GO:0007588)2.28112713
165nonmotile primary cilium assembly (GO:0035058)2.27196069
166photoreceptor cell maintenance (GO:0045494)2.27177240
167negative regulation of mast cell activation (GO:0033004)2.26396250
168detection of molecule of bacterial origin (GO:0032490)2.21260623
169cilium movement (GO:0003341)14.2937012
170axonemal dynein complex assembly (GO:0070286)13.9958332
171axoneme assembly (GO:0035082)12.7212159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.94539980
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61966174
3VDR_22108803_ChIP-Seq_LS180_Human2.56569505
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55403280
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43985121
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.39069271
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.36716606
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32314948
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30975120
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.28370748
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.23768187
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.21869602
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21273362
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18774089
15RNF2_27304074_Chip-Seq_NSC_Mouse2.17702130
16SMAD4_21799915_ChIP-Seq_A2780_Human2.13646534
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.13097540
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10000732
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08687112
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.07840790
21P300_19829295_ChIP-Seq_ESCs_Human2.02500685
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00521728
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.96953695
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.96753403
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95267077
26ZNF274_21170338_ChIP-Seq_K562_Hela1.93548090
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89967039
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89967039
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87690969
30EZH2_22144423_ChIP-Seq_EOC_Human1.83805524
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83454677
32AHR_22903824_ChIP-Seq_MCF-7_Human1.82795028
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.81599869
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.79967272
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79781627
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.76979440
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72481051
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70056875
39P53_22387025_ChIP-Seq_ESCs_Mouse1.67832166
40FUS_26573619_Chip-Seq_HEK293_Human1.66539315
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.66237702
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63531454
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.63391711
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63068777
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.60992009
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.60581413
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59677200
48EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.59494704
49ZFX_18555785_Chip-Seq_ESCs_Mouse1.58538015
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58184040
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.56540704
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56295851
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.55280349
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.55156813
55STAT3_23295773_ChIP-Seq_U87_Human1.53450745
56ER_23166858_ChIP-Seq_MCF-7_Human1.52808037
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.51427673
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51015049
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50538039
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49500120
61RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45373898
62P300_18555785_Chip-Seq_ESCs_Mouse1.45001088
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44561220
64LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44103648
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43121133
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41432125
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.39976511
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37239111
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37185041
70NMYC_18555785_Chip-Seq_ESCs_Mouse1.36688848
71STAT1_20625510_ChIP-Seq_HELA_Human1.36447340
72EWS_26573619_Chip-Seq_HEK293_Human1.35393361
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32990198
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32831542
75PU1_27457419_Chip-Seq_LIVER_Mouse1.32460111
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32353720
77BCAT_22108803_ChIP-Seq_LS180_Human1.30851328
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.30740938
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30563118
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30438310
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29284738
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29196297
83TCF4_23295773_ChIP-Seq_U87_Human1.29190101
84CTCF_18555785_Chip-Seq_ESCs_Mouse1.28965896
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28089645
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.28089645
87IRF1_19129219_ChIP-ChIP_H3396_Human1.28027941
88DROSHA_22980978_ChIP-Seq_HELA_Human1.27724376
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26941541
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26359925
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25530742
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25271410
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.25085369
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24621490
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24512430
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24030730
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.23581368
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23420647
99TCF4_22108803_ChIP-Seq_LS180_Human1.23303282
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22127379
101SMRT_27268052_Chip-Seq_Bcells_Human1.22118022
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.21733097
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.21475461
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.20954571
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.20631389
106AR_21572438_ChIP-Seq_LNCaP_Human1.19996916
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19823178
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18898619
109EED_16625203_ChIP-ChIP_MESCs_Mouse1.18858584
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18277459
111RUNX2_22187159_ChIP-Seq_PCA_Human1.18256943
112JUN_21703547_ChIP-Seq_K562_Human1.18218536
113AR_20517297_ChIP-Seq_VCAP_Human1.17362455
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16243170
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15827844
116AR_25329375_ChIP-Seq_VCAP_Human1.15333846
117HOXB7_26014856_ChIP-Seq_BT474_Human1.15039429
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.14614224
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13569843
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13492675
121TP53_18474530_ChIP-ChIP_U2OS_Human1.11804133
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11072140
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09669554
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09584356
125LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09506196
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.09371080
127CBP_20019798_ChIP-Seq_JUKART_Human1.09129893
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09129893
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08510823
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08345696
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07565938
132SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06957603
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06863278
134NCOR_22424771_ChIP-Seq_293T_Human1.06861785
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.05841904
136RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04742290
137ERA_21632823_ChIP-Seq_H3396_Human1.03378691
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03306224
139ETV1_20927104_ChIP-Seq_GIST48_Human1.03046374
140SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03038798
141VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02074038
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01281524
143NANOG_19829295_ChIP-Seq_ESCs_Human1.00707579
144SOX2_19829295_ChIP-Seq_ESCs_Human1.00707579
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00483652
146TP63_23658742_ChIP-Seq_EP156T_Human1.00188123
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97421643
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97370732
149TP53_22573176_ChIP-Seq_HFKS_Human0.96104768
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.96063055
151TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94770142
152ESR2_21235772_ChIP-Seq_MCF-7_Human0.93850250
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.93165108
154TAF15_26573619_Chip-Seq_HEK293_Human0.93002560
155PHF8_20622853_ChIP-Seq_HELA_Human0.92086959
156P53_21459846_ChIP-Seq_SAOS-2_Human0.90877035
157IGF1R_20145208_ChIP-Seq_DFB_Human0.90559090
158REST_21632747_ChIP-Seq_MESCs_Mouse0.90130479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.27037054
2MP0009780_abnormal_chondrocyte_physiolo6.31160911
3MP0008875_abnormal_xenobiotic_pharmacok4.62715485
4MP0001984_abnormal_olfaction4.58829937
5MP0002653_abnormal_ependyma_morphology3.97166526
6MP0002102_abnormal_ear_morphology3.00197319
7MP0005646_abnormal_pituitary_gland2.78117602
8MP0006292_abnormal_olfactory_placode2.71066966
9MP0004885_abnormal_endolymph2.63980392
10MP0004381_abnormal_hair_follicle2.56187940
11MP0001188_hyperpigmentation2.39239899
12MP0002132_abnormal_respiratory_system2.38984373
13MP0004043_abnormal_pH_regulation2.38056087
14MP0005623_abnormal_meninges_morphology2.35808541
15MP0005075_abnormal_melanosome_morpholog2.12888057
16MP0002909_abnormal_adrenal_gland2.12758122
17MP0004782_abnormal_surfactant_physiolog2.04282880
18MP0002638_abnormal_pupillary_reflex2.00372723
19MP0003718_maternal_effect1.98235842
20MP0000372_irregular_coat_pigmentation1.92903870
21MP0002160_abnormal_reproductive_system1.92854572
22MP0003878_abnormal_ear_physiology1.91594433
23MP0005377_hearing/vestibular/ear_phenot1.91594433
24MP0002277_abnormal_respiratory_mucosa1.90669704
25MP0002876_abnormal_thyroid_physiology1.89941223
26MP0003879_abnormal_hair_cell1.89143803
27MP0001968_abnormal_touch/_nociception1.79812884
28MP0005171_absent_coat_pigmentation1.79128932
29MP0002938_white_spotting1.78331698
30MP0002928_abnormal_bile_duct1.77897419
31MP0003195_calcinosis1.74600956
32MP0000383_abnormal_hair_follicle1.73398860
33MP0008004_abnormal_stomach_pH1.72099770
34MP0002736_abnormal_nociception_after1.61162460
35MP0002249_abnormal_larynx_morphology1.56169418
36MP0009046_muscle_twitch1.53293580
37MP0008872_abnormal_physiological_respon1.53147372
38MP0003937_abnormal_limbs/digits/tail_de1.48564095
39MP0001293_anophthalmia1.47594125
40MP0008995_early_reproductive_senescence1.42921224
41MP0005389_reproductive_system_phenotype1.40884814
42MP0004133_heterotaxia1.38171438
43MP0001485_abnormal_pinna_reflex1.35369481
44MP0000566_synostosis1.33368369
45MP0001765_abnormal_ion_homeostasis1.31361703
46MP0005395_other_phenotype1.30784358
47MP0002095_abnormal_skin_pigmentation1.28542651
48MP0008789_abnormal_olfactory_epithelium1.28531452
49MP0004742_abnormal_vestibular_system1.27248547
50MP0003787_abnormal_imprinting1.26345287
51MP0005394_taste/olfaction_phenotype1.25831099
52MP0005499_abnormal_olfactory_system1.25831099
53MP0003638_abnormal_response/metabolism_1.25687112
54MP0004019_abnormal_vitamin_homeostasis1.24530544
55MP0001177_atelectasis1.19786683
56MP0001501_abnormal_sleep_pattern1.19601779
57MP0005167_abnormal_blood-brain_barrier1.19261254
58MP0003724_increased_susceptibility_to1.17979822
59MP0004130_abnormal_muscle_cell1.15906139
60MP0002734_abnormal_mechanical_nocicepti1.15174734
61MP0005397_hematopoietic_system_phenotyp1.14049370
62MP0001545_abnormal_hematopoietic_system1.14049370
63MP0005187_abnormal_penis_morphology1.13496333
64MP0005083_abnormal_biliary_tract1.12674921
65MP0005551_abnormal_eye_electrophysiolog1.11948926
66MP0002282_abnormal_trachea_morphology1.11390644
67MP0002735_abnormal_chemical_nociception1.11225773
68MP0006072_abnormal_retinal_apoptosis1.10644168
69MP0000026_abnormal_inner_ear1.10252324
70MP0006276_abnormal_autonomic_nervous1.09885690
71MP0002557_abnormal_social/conspecific_i1.08856523
72MP0001502_abnormal_circadian_rhythm1.05808966
73MP0009697_abnormal_copulation1.04958281
74MP0002210_abnormal_sex_determination1.04136288
75MP0001958_emphysema1.02732416
76MP0003938_abnormal_ear_development1.02647381
77MP0005248_abnormal_Harderian_gland1.02588371
78MP0002168_other_aberrant_phenotype1.02527180
79MP0008057_abnormal_DNA_replication0.99073086
80MP0002133_abnormal_respiratory_system0.96719817
81MP0005388_respiratory_system_phenotype0.96719817
82MP0004858_abnormal_nervous_system0.94055398
83MP0000681_abnormal_thyroid_gland0.93139726
84MP0003941_abnormal_skin_development0.91090375
85MP0001986_abnormal_taste_sensitivity0.91090226
86MP0002163_abnormal_gland_morphology0.90655722
87MP0000762_abnormal_tongue_morphology0.88970078
88MP0005636_abnormal_mineral_homeostasis0.88308560
89MP0001119_abnormal_female_reproductive0.88252242
90MP0003011_delayed_dark_adaptation0.87670832
91MP0010678_abnormal_skin_adnexa0.87447477
92MP0000631_abnormal_neuroendocrine_gland0.86681366
93MP0002233_abnormal_nose_morphology0.85657767
94MP0009250_abnormal_appendicular_skeleto0.85049008
95MP0001440_abnormal_grooming_behavior0.83701969
96MP0002109_abnormal_limb_morphology0.83159358
97MP0003698_abnormal_male_reproductive0.82800960
98MP0001929_abnormal_gametogenesis0.82302661
99MP0005410_abnormal_fertilization0.81363979
100MP0005365_abnormal_bile_salt0.81015486
101MP0003866_abnormal_defecation0.80542262
102MP0008058_abnormal_DNA_repair0.80349661
103MP0001664_abnormal_digestion0.80057398
104MP0001970_abnormal_pain_threshold0.78990470
105MP0009384_cardiac_valve_regurgitation0.78488238
106MP0000778_abnormal_nervous_system0.78451797
107MP0001286_abnormal_eye_development0.78157101
108MP0008877_abnormal_DNA_methylation0.77357230
109MP0002752_abnormal_somatic_nervous0.77284697
110MP0001919_abnormal_reproductive_system0.77158429
111MP0000049_abnormal_middle_ear0.75294726
112MP0003121_genomic_imprinting0.74906526
113MP0001486_abnormal_startle_reflex0.74763021
114MP0001963_abnormal_hearing_physiology0.74581319
115MP0002272_abnormal_nervous_system0.74482170
116MP0003646_muscle_fatigue0.74282787
117MP0002837_dystrophic_cardiac_calcinosis0.73842442
118MP0005253_abnormal_eye_physiology0.73228412
119MP0005391_vision/eye_phenotype0.72848878
120MP0005645_abnormal_hypothalamus_physiol0.72798642
121MP0008775_abnormal_heart_ventricle0.72734982
122MP0010329_abnormal_lipoprotein_level0.72571043
123MP0009765_abnormal_xenobiotic_induced0.72506558
124MP0009764_decreased_sensitivity_to0.72238477
125MP0000230_abnormal_systemic_arterial0.72008753
126MP0005670_abnormal_white_adipose0.71803728
127MP0003755_abnormal_palate_morphology0.71581404
128MP0002116_abnormal_craniofacial_bone0.70429484
129MP0005671_abnormal_response_to0.70271025
130MP0009745_abnormal_behavioral_response0.70071877
131MP0002136_abnormal_kidney_physiology0.70052958
132MP0000653_abnormal_sex_gland0.69816365
133MP0010155_abnormal_intestine_physiology0.69787402
134MP0003880_abnormal_central_pattern0.68520261
135MP0005195_abnormal_posterior_eye0.68447166
136MP0001879_abnormal_lymphatic_vessel0.68217444
137MP0002098_abnormal_vibrissa_morphology0.67888102
138MP0000432_abnormal_head_morphology0.66635881
139MP0005379_endocrine/exocrine_gland_phen0.66382138
140MP0002572_abnormal_emotion/affect_behav0.64540879
141MP0000427_abnormal_hair_cycle0.64534848
142MP0005085_abnormal_gallbladder_physiolo0.64282206
143MP0010386_abnormal_urinary_bladder0.63784422
144MP0002229_neurodegeneration0.63401840
145MP0003119_abnormal_digestive_system0.61319732
146MP0009643_abnormal_urine_homeostasis0.59086109
147MP0001790_abnormal_immune_system0.58163573
148MP0005387_immune_system_phenotype0.58163573
149MP0005503_abnormal_tendon_morphology0.58076403
150MP0002138_abnormal_hepatobiliary_system0.57709101
151MP0001324_abnormal_eye_pigmentation0.57258033

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)8.39597812
2Abnormal respiratory epithelium morphology (HP:0012253)8.03171026
3Abnormal respiratory motile cilium morphology (HP:0005938)8.03171026
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.74519086
5Absent/shortened dynein arms (HP:0200106)6.74519086
6Bronchiectasis (HP:0002110)5.50118219
7Chronic bronchitis (HP:0004469)5.11000875
8True hermaphroditism (HP:0010459)4.85548941
9Pancreatic fibrosis (HP:0100732)4.62945112
10Nasal polyposis (HP:0100582)3.91034678
11Recurrent sinusitis (HP:0011108)3.87010742
12Pancreatic cysts (HP:0001737)3.56072441
13Occipital encephalocele (HP:0002085)3.52844974
14Nephronophthisis (HP:0000090)3.26410202
15Abnormality of the nasal mucosa (HP:0000433)3.08365672
16Abnormality of midbrain morphology (HP:0002418)3.06931386
17Molar tooth sign on MRI (HP:0002419)3.06931386
18Chronic hepatic failure (HP:0100626)3.06018102
19Postaxial foot polydactyly (HP:0001830)2.96241933
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.87299833
21Cystic liver disease (HP:0006706)2.81537657
22Infertility (HP:0000789)2.78235928
23Medial flaring of the eyebrow (HP:0010747)2.70792837
24Abnormality of the renal medulla (HP:0100957)2.69776522
25Congenital hepatic fibrosis (HP:0002612)2.67964472
26Bile duct proliferation (HP:0001408)2.67132396
27Abnormal biliary tract physiology (HP:0012439)2.67132396
28Chronic sinusitis (HP:0011109)2.63165794
29Median cleft lip (HP:0000161)2.63101499
30Chronic otitis media (HP:0000389)2.59777268
31Supernumerary spleens (HP:0009799)2.55378659
32Abnormal rod and cone electroretinograms (HP:0008323)2.51846418
33Congenital primary aphakia (HP:0007707)2.49780488
34Gait imbalance (HP:0002141)2.48714096
35Male pseudohermaphroditism (HP:0000037)2.43674626
36Bronchitis (HP:0012387)2.43530542
37Nephrogenic diabetes insipidus (HP:0009806)2.41704384
38Hypochromic anemia (HP:0001931)2.41466002
39Decreased circulating renin level (HP:0003351)2.41378001
40Preaxial hand polydactyly (HP:0001177)2.33584515
41Tubulointerstitial nephritis (HP:0001970)2.29087095
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28067093
43Hyperactive renin-angiotensin system (HP:0000841)2.27223201
44Congenital stationary night blindness (HP:0007642)2.24669053
45Facial cleft (HP:0002006)2.24465406
46Fibular hypoplasia (HP:0003038)2.20452008
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20383830
48Obstructive lung disease (HP:0006536)2.19361096
49Chronic obstructive pulmonary disease (HP:0006510)2.19361096
50Concave nail (HP:0001598)2.18810557
51Chromsome breakage (HP:0040012)2.09331983
52Atelectasis (HP:0100750)2.05013578
53Abnormal ciliary motility (HP:0012262)13.0291668
54Abnormal respiratory motile cilium physiology (HP:0012261)12.1697735
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6806036
56Neonatal short-limb short stature (HP:0008921)1.99982497
57Decreased central vision (HP:0007663)1.99432968
58Recurrent otitis media (HP:0000403)1.99379974
59Poor coordination (HP:0002370)1.98334073
60Hip dysplasia (HP:0001385)1.96423649
61Abnormal drinking behavior (HP:0030082)1.91698922
62Polydipsia (HP:0001959)1.91698922
63Sclerocornea (HP:0000647)1.91429418
64Postaxial hand polydactyly (HP:0001162)1.88716548
65Recurrent bronchitis (HP:0002837)1.88387252
66Genital tract atresia (HP:0001827)1.87921681
67Anencephaly (HP:0002323)1.87661111
68Abnormality of permanent molar morphology (HP:0011071)1.80568109
69Abnormality of the dental root (HP:0006486)1.80568109
70Taurodontia (HP:0000679)1.80568109
71Abnormality of molar (HP:0011077)1.77028674
72Abnormality of molar morphology (HP:0011070)1.77028674
73Bifid tongue (HP:0010297)1.76123752
74Abnormality of macular pigmentation (HP:0008002)1.75488842
75Furrowed tongue (HP:0000221)1.72402938
76Type II lissencephaly (HP:0007260)1.71129623
77Renal salt wasting (HP:0000127)1.70986395
78Sex reversal (HP:0012245)1.70951389
79Abnormal sex determination (HP:0012244)1.70951389
80Oculomotor apraxia (HP:0000657)1.68870503
81Vaginal atresia (HP:0000148)1.67924259
82Abnormality of the dental pulp (HP:0006479)1.66467216
83Male infertility (HP:0003251)1.65223067
84Abnormality of renin-angiotensin system (HP:0000847)1.65146445
85Abolished electroretinogram (ERG) (HP:0000550)1.65027485
86Nephropathy (HP:0000112)1.63581866
87Follicular hyperkeratosis (HP:0007502)1.63565742
88Hyperaldosteronism (HP:0000859)1.57399774
89Absent frontal sinuses (HP:0002688)1.56375033
90Abnormality of abdominal situs (HP:0011620)1.56143707
91Abdominal situs inversus (HP:0003363)1.56143707
92Tubular atrophy (HP:0000092)1.55900039
93Aganglionic megacolon (HP:0002251)1.53304804
94Tubulointerstitial abnormality (HP:0001969)1.51848450
95Aplasia/Hypoplasia of the lens (HP:0008063)1.49915639
96Asplenia (HP:0001746)1.47549638
97Retinitis pigmentosa (HP:0000510)1.45323642
98Septo-optic dysplasia (HP:0100842)1.45020017
99Abnormality of the renal cortex (HP:0011035)1.44921588
10011 pairs of ribs (HP:0000878)1.44562220
101Hypodontia (HP:0000668)1.44076257
102Attenuation of retinal blood vessels (HP:0007843)1.42909942
103Natal tooth (HP:0000695)1.41920851
104Duplicated collecting system (HP:0000081)1.41146287
105Bell-shaped thorax (HP:0001591)1.41004831
106Tubulointerstitial fibrosis (HP:0005576)1.40003034
107Polyuria (HP:0000103)1.38828483
108Severe Myopia (HP:0011003)1.36631399
109Febrile seizures (HP:0002373)1.36558929
110Severe visual impairment (HP:0001141)1.35914008
111Chorioretinal coloboma (HP:0000567)1.35611100
112Sparse lateral eyebrow (HP:0005338)1.35563347
113Oligohydramnios (HP:0001562)1.35470510
114Bony spicule pigmentary retinopathy (HP:0007737)1.35426753
115Aplasia/Hypoplasia of the fibula (HP:0006492)1.33968689
116Abnormality of the renal collecting system (HP:0004742)1.33835589
117Hypokalemic alkalosis (HP:0001949)1.33017607
118Stage 5 chronic kidney disease (HP:0003774)1.33004973
119Abnormality of the fovea (HP:0000493)1.32743459
120Renal dysplasia (HP:0000110)1.31139122
121Narrow forehead (HP:0000341)1.29735400
122Cheilitis (HP:0100825)1.28418168
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.28049116
124Abnormality of the middle phalanges of the toes (HP:0010183)1.27978273
125Hyperkalemia (HP:0002153)1.27481127
126Abnormality of chloride homeostasis (HP:0011422)1.27315053
127Short femoral neck (HP:0100864)1.26676271
128Abnormality of renal excretion (HP:0011036)1.26208981
129Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.25612249
130Abnormality of the frontal sinuses (HP:0002687)1.23591285
131Cone-rod dystrophy (HP:0000548)1.23490391
132Conical tooth (HP:0000698)1.17686588
133Hemiparesis (HP:0001269)1.14860998
134Lip pit (HP:0100267)1.14617463
135Increased corneal curvature (HP:0100692)1.13138096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.13582291
2PNCK3.94605611
3STK38L3.62422432
4TLK13.22385621
5MKNK22.97015662
6CASK2.79905369
7MAPKAPK32.60939062
8ERBB32.47687207
9TAOK32.16184507
10ZAK1.92074349
11WNK41.91644812
12SIK31.87728464
13MUSK1.87416189
14MST41.86883681
15GRK11.86031586
16PINK11.85580208
17WEE11.79600527
18ADRBK21.71193252
19RPS6KA41.68893330
20TTK1.67659403
21STK161.64413835
22TNIK1.63136371
23CDK31.55794878
24SGK21.55368874
25PLK21.54206842
26MAP4K21.51253364
27MAP2K71.51236770
28MKNK11.49447616
29BMPR1B1.48418634
30LATS11.45462416
31KIT1.45103837
32MAP2K21.37182290
33MST1R1.36422678
34SRPK11.34939445
35IRAK31.33817915
36VRK11.32136219
37BMPR21.30640550
38EPHA21.26087207
39DAPK21.25762203
40STK391.23209271
41BLK1.21536539
42AKT31.20465761
43PTK2B1.20328523
44EIF2AK21.17513175
45ERBB21.16168604
46PIK3CA1.14582817
47ADRBK11.13638798
48GRK61.12949076
49TXK1.11554685
50IRAK11.10551667
51PRKCI1.10487500
52EPHA31.10150785
53CDK81.09968505
54IKBKE1.07306568
55MAP3K141.06558458
56WNK31.06155061
57CSK1.00013282
58INSRR0.96742664
59PLK30.95900584
60YES10.94226218
61CHUK0.94205915
62NEK60.92930036
63TNK20.92710337
64SGK2230.92690761
65SGK4940.92690761
66BCR0.92587467
67AURKA0.91849553
68NTRK20.91064831
69GRK70.91040204
70NUAK10.90987188
71STK30.90069491
72IKBKB0.87896001
73PDK20.87287719
74PAK30.86133590
75STK380.85160399
76MAPK130.82628859
77NLK0.81164983
78PRKCG0.81015704
79TBK10.78377771
80PRKCQ0.77215425
81PLK40.76621610
82DYRK30.76565979
83NME10.71546123
84TRPM70.70791290
85TGFBR20.70102078
86GRK50.69786909
87MAP3K120.68849034
88PRKCE0.67673028
89CAMKK20.66552495
90MAP3K40.66369379
91RPS6KA50.66156562
92PRPF4B0.65662453
93BRAF0.65085326
94MOS0.65026935
95DYRK1A0.64313693
96ACVR1B0.63678284
97FGR0.62063981
98SGK30.57804748
99CAMKK10.57719895
100NTRK30.57541130
101ITK0.57330862
102CSNK1G10.56644088
103CHEK20.55829915
104TIE10.54796342
105ABL10.54383615
106TEC0.50102792
107MAP3K20.49770096
108FRK0.48346337
109MAP2K10.48073311
110PRKCA0.46526054
111IRAK40.46053793
112EPHA40.44656697
113PLK10.43319589
114ARAF0.41977064
115PRKD20.41766232
116PRKCD0.41640896
117HIPK20.40957398
118RPS6KA20.40359107
119PRKAA20.40313730
120MAPK70.39856388
121SGK10.39598086
122LATS20.39096821
123LRRK20.38985587
124DYRK20.38929688
125RIPK40.38282868
126BRSK20.38036871
127CAMK2A0.37667245
128LYN0.37650501
129TSSK60.37238949
130MAPKAPK50.37181183
131STK100.36365444
132FER0.36070140
133LCK0.35484295
134BCKDK0.34860794
135NEK90.33965854
136OXSR10.33329412
137IGF1R0.32439368
138RPS6KC10.31523964
139RPS6KL10.31523964
140RPS6KB10.31513546
141PRKCZ0.31318857
142SYK0.31113777
143MAPK120.31077051
144CDK70.30815236
145MAP2K60.30778736
146STK240.30451357
147PRKACA0.30092161
148MAPKAPK20.29801271
149LMTK20.29732620
150CSNK1G20.27437921
151MYLK0.26640304
152CSNK1A1L0.26406965
153ROCK10.26396978
154FES0.26321601
155PRKACG0.26120770
156RPS6KA60.25231946
157CSNK1A10.24840425
158MATK0.24064632

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.29700573
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.69543946
3Chemical carcinogenesis_Homo sapiens_hsa052043.61766066
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.20866786
5Vitamin B6 metabolism_Homo sapiens_hsa007503.07629682
6Nicotine addiction_Homo sapiens_hsa050332.92755661
7Caffeine metabolism_Homo sapiens_hsa002322.84337905
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.74523534
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.62288813
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.61980699
11Linoleic acid metabolism_Homo sapiens_hsa005912.60388884
12Phenylalanine metabolism_Homo sapiens_hsa003602.51964864
13Phototransduction_Homo sapiens_hsa047442.50075786
14Circadian rhythm_Homo sapiens_hsa047102.37840694
15Fanconi anemia pathway_Homo sapiens_hsa034602.29815482
16Tyrosine metabolism_Homo sapiens_hsa003502.24808651
17Tryptophan metabolism_Homo sapiens_hsa003802.22807985
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20185627
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.98913073
20beta-Alanine metabolism_Homo sapiens_hsa004101.88121844
21Autoimmune thyroid disease_Homo sapiens_hsa053201.86542807
22Taste transduction_Homo sapiens_hsa047421.84315775
23Nitrogen metabolism_Homo sapiens_hsa009101.76621399
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73298867
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.73161754
26Huntingtons disease_Homo sapiens_hsa050161.68954389
27Allograft rejection_Homo sapiens_hsa053301.57284887
28Ovarian steroidogenesis_Homo sapiens_hsa049131.48773710
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47928392
30Homologous recombination_Homo sapiens_hsa034401.42357652
31ABC transporters_Homo sapiens_hsa020101.38284783
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37695747
33Purine metabolism_Homo sapiens_hsa002301.36344035
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34987021
35Arachidonic acid metabolism_Homo sapiens_hsa005901.31158488
36Dorso-ventral axis formation_Homo sapiens_hsa043201.30966737
37Sphingolipid metabolism_Homo sapiens_hsa006001.29883988
38Graft-versus-host disease_Homo sapiens_hsa053321.29372527
39Collecting duct acid secretion_Homo sapiens_hsa049661.29199689
40Calcium signaling pathway_Homo sapiens_hsa040201.28680658
41Rheumatoid arthritis_Homo sapiens_hsa053231.28065217
42Hedgehog signaling pathway_Homo sapiens_hsa043401.20099537
43Glutathione metabolism_Homo sapiens_hsa004801.17402580
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15226227
45Hematopoietic cell lineage_Homo sapiens_hsa046401.13284602
46Basal transcription factors_Homo sapiens_hsa030221.12737131
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12161797
48Morphine addiction_Homo sapiens_hsa050321.11819307
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11353817
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11324607
51Cell cycle_Homo sapiens_hsa041101.10674247
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10160286
53Peroxisome_Homo sapiens_hsa041461.08891877
54cAMP signaling pathway_Homo sapiens_hsa040241.08890979
55Mineral absorption_Homo sapiens_hsa049781.07368197
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.06431490
57Ether lipid metabolism_Homo sapiens_hsa005651.06150494
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05589702
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05231301
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03232933
61Histidine metabolism_Homo sapiens_hsa003401.03011245
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.02719529
63Circadian entrainment_Homo sapiens_hsa047131.02214149
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99485991
65Nucleotide excision repair_Homo sapiens_hsa034200.98732134
66Glutamatergic synapse_Homo sapiens_hsa047240.98211744
67Insulin secretion_Homo sapiens_hsa049110.91262256
68Phagosome_Homo sapiens_hsa041450.88665491
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88621796
70GABAergic synapse_Homo sapiens_hsa047270.88209453
71Vitamin digestion and absorption_Homo sapiens_hsa049770.87467432
72Sulfur metabolism_Homo sapiens_hsa009200.87131941
73Glycerolipid metabolism_Homo sapiens_hsa005610.86732722
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86652286
75Pyrimidine metabolism_Homo sapiens_hsa002400.84783249
76Butanoate metabolism_Homo sapiens_hsa006500.83510754
77Type I diabetes mellitus_Homo sapiens_hsa049400.82131994
78RNA degradation_Homo sapiens_hsa030180.81424467
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81219693
80Fatty acid degradation_Homo sapiens_hsa000710.80446341
81Malaria_Homo sapiens_hsa051440.79170861
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76972140
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75122246
84Basal cell carcinoma_Homo sapiens_hsa052170.74956957
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.73871419
86Amphetamine addiction_Homo sapiens_hsa050310.72830142
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71532073
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69256799
89Herpes simplex infection_Homo sapiens_hsa051680.69007673
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.68140375
91Renin secretion_Homo sapiens_hsa049240.67543612
92Cardiac muscle contraction_Homo sapiens_hsa042600.67113823
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66847795
94Oxidative phosphorylation_Homo sapiens_hsa001900.66703457
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66562303
96Arginine and proline metabolism_Homo sapiens_hsa003300.65203408
97Salivary secretion_Homo sapiens_hsa049700.64934349
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.64260736
99Serotonergic synapse_Homo sapiens_hsa047260.63146632
100Starch and sucrose metabolism_Homo sapiens_hsa005000.62258865
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59452784
102ECM-receptor interaction_Homo sapiens_hsa045120.57483650
103Asthma_Homo sapiens_hsa053100.54358574
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53892175
105Regulation of autophagy_Homo sapiens_hsa041400.51653432
106Hepatitis B_Homo sapiens_hsa051610.51613962
107Base excision repair_Homo sapiens_hsa034100.51238687
108Wnt signaling pathway_Homo sapiens_hsa043100.51019682
109Hippo signaling pathway_Homo sapiens_hsa043900.50990918
110African trypanosomiasis_Homo sapiens_hsa051430.50470059
111Tight junction_Homo sapiens_hsa045300.49348180
112Synaptic vesicle cycle_Homo sapiens_hsa047210.48466861
113Cocaine addiction_Homo sapiens_hsa050300.47699422
114Fatty acid biosynthesis_Homo sapiens_hsa000610.47199861
115Viral myocarditis_Homo sapiens_hsa054160.46476186
116Primary immunodeficiency_Homo sapiens_hsa053400.46202734
117Measles_Homo sapiens_hsa051620.46151897
118Ras signaling pathway_Homo sapiens_hsa040140.44759555
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.43637600
120Melanoma_Homo sapiens_hsa052180.43633972
121PPAR signaling pathway_Homo sapiens_hsa033200.43311282
122Selenocompound metabolism_Homo sapiens_hsa004500.43295388
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43142279
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42650508
125Pathways in cancer_Homo sapiens_hsa052000.42455618
126Inositol phosphate metabolism_Homo sapiens_hsa005620.42067475
127Salmonella infection_Homo sapiens_hsa051320.42063386
128Metabolic pathways_Homo sapiens_hsa011000.40665573
129Gastric acid secretion_Homo sapiens_hsa049710.39505920
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38797193
131Retinol metabolism_Homo sapiens_hsa008300.38455720
132p53 signaling pathway_Homo sapiens_hsa041150.38254138
133Antigen processing and presentation_Homo sapiens_hsa046120.36518875
134Notch signaling pathway_Homo sapiens_hsa043300.36368038
135Staphylococcus aureus infection_Homo sapiens_hsa051500.34167122
136Mismatch repair_Homo sapiens_hsa034300.33341664
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.32864479
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.32207351
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32014957
140Oxytocin signaling pathway_Homo sapiens_hsa049210.31636061
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29557313
142Alzheimers disease_Homo sapiens_hsa050100.28887979
143Complement and coagulation cascades_Homo sapiens_hsa046100.23858000
144Sulfur relay system_Homo sapiens_hsa041220.21534105
145Bile secretion_Homo sapiens_hsa049760.20441148
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18731078

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