CCDC172

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.80159391
2chromosome organization involved in meiosis (GO:0070192)7.51435605
3meiotic nuclear division (GO:0007126)7.31794055
4male meiosis I (GO:0007141)6.96490097
5regulation of meiosis I (GO:0060631)6.78698358
6cilium or flagellum-dependent cell motility (GO:0001539)6.68796929
7fusion of sperm to egg plasma membrane (GO:0007342)6.48325952
8meiosis I (GO:0007127)5.92831299
9meiotic chromosome segregation (GO:0045132)5.57347707
10acrosome assembly (GO:0001675)5.49486475
11multicellular organism reproduction (GO:0032504)5.41115059
12meiotic cell cycle process (GO:1903046)5.38054023
13sperm-egg recognition (GO:0035036)5.31888465
14binding of sperm to zona pellucida (GO:0007339)5.18677358
15gene silencing by RNA (GO:0031047)5.17074651
16sperm motility (GO:0030317)5.13435761
17plasma membrane fusion (GO:0045026)4.89004598
18spermatid development (GO:0007286)4.78338368
19DNA alkylation (GO:0006305)4.68240397
20DNA methylation (GO:0006306)4.68240397
21acrosome reaction (GO:0007340)4.68103733
22cell-cell recognition (GO:0009988)4.67296334
23meiotic cell cycle (GO:0051321)4.65267810
24microtubule depolymerization (GO:0007019)4.64538390
25histone H3-K36 demethylation (GO:0070544)4.63585621
26reciprocal DNA recombination (GO:0035825)4.57243696
27reciprocal meiotic recombination (GO:0007131)4.57243696
28oogenesis (GO:0048477)4.53075756
29negative regulation of gene silencing (GO:0060969)4.51367552
30attachment of spindle microtubules to kinetochore (GO:0008608)4.47360874
31regulation of DNA endoreduplication (GO:0032875)4.44886137
32regulation of transcription from RNA polymerase I promoter (GO:0006356)4.42065479
33axonemal dynein complex assembly (GO:0070286)4.38782004
34epithelial cilium movement (GO:0003351)4.25870807
35positive regulation of meiosis (GO:0045836)4.22393966
36resolution of meiotic recombination intermediates (GO:0000712)4.21201731
37reproduction (GO:0000003)4.20403658
38negative regulation of meiosis (GO:0045835)4.15679260
39sister chromatid cohesion (GO:0007062)4.11135584
40negative regulation of DNA-dependent DNA replication (GO:2000104)4.07225594
41positive regulation of meiotic cell cycle (GO:0051446)4.01003716
42spermatogenesis (GO:0007283)4.00575959
43male gamete generation (GO:0048232)4.00134217
44germ cell development (GO:0007281)3.99372084
45fertilization (GO:0009566)3.98688849
46regulation of histone H3-K9 methylation (GO:0051570)3.97741533
47female gamete generation (GO:0007292)3.96755491
48cell wall macromolecule catabolic process (GO:0016998)3.95172567
49cell wall macromolecule metabolic process (GO:0044036)3.95172567
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.94358860
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.94358860
52positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.93222419
53nuclear pore complex assembly (GO:0051292)3.91986430
54gamete generation (GO:0007276)3.82851187
55neurofilament cytoskeleton organization (GO:0060052)3.82175816
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.79544356
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.79544356
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.79544356
59negative regulation of sister chromatid segregation (GO:0033046)3.79544356
60oocyte maturation (GO:0001556)3.76005289
61positive regulation of translational initiation (GO:0045948)3.68511981
62nuclear pore organization (GO:0006999)3.66648463
63CENP-A containing nucleosome assembly (GO:0034080)3.66275114
64histone H3-K9 demethylation (GO:0033169)3.64418375
65mismatch repair (GO:0006298)3.63180321
66mitotic spindle assembly checkpoint (GO:0007094)3.61794485
67motile cilium assembly (GO:0044458)3.61583831
68DNA synthesis involved in DNA repair (GO:0000731)3.60753833
69mitotic spindle checkpoint (GO:0071174)3.59645092
70single fertilization (GO:0007338)3.57642695
71cilium movement (GO:0003341)3.57004607
72proteasome assembly (GO:0043248)3.56388213
73regulation of centriole replication (GO:0046599)3.56044119
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55448856
75cellular process involved in reproduction in multicellular organism (GO:0022412)3.52982400
76spindle assembly checkpoint (GO:0071173)3.52706134
77synapsis (GO:0007129)3.51389168
78regulation of mitotic sister chromatid separation (GO:0010965)3.50110572
79regulation of mitotic sister chromatid segregation (GO:0033047)3.50110572
80regulation of sister chromatid segregation (GO:0033045)3.50110572
81DNA methylation or demethylation (GO:0044728)3.49606364
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48364690
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48364690
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.46701343
85histone H2A acetylation (GO:0043968)3.45541611
86regulation of meiosis (GO:0040020)3.45476875
87gene silencing (GO:0016458)3.44564494
88histone exchange (GO:0043486)3.44557391
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.43356057
90negative regulation of inclusion body assembly (GO:0090084)3.41872228
91histone H4-K12 acetylation (GO:0043983)3.40186256
92positive regulation of cellular response to oxidative stress (GO:1900409)3.39867492
93positive regulation of response to oxidative stress (GO:1902884)3.39867492
94spindle checkpoint (GO:0031577)3.34710183
95mitotic chromosome condensation (GO:0007076)3.29304128
96regulation of chromatin silencing (GO:0031935)3.25751330
97establishment of integrated proviral latency (GO:0075713)3.20699816
98microtubule polymerization or depolymerization (GO:0031109)3.16543090
99mitotic metaphase plate congression (GO:0007080)3.15408852
100regulation of spindle checkpoint (GO:0090231)3.14307447
101regulation of cilium movement (GO:0003352)3.12237166
102regulation of translational termination (GO:0006449)3.10168867
103photoreceptor cell maintenance (GO:0045494)3.09733117
104nuclear division (GO:0000280)3.09599898
105chromatin remodeling at centromere (GO:0031055)3.07838418
106protein K6-linked ubiquitination (GO:0085020)3.06417803
107DNA replication-independent nucleosome organization (GO:0034724)3.04224094
108DNA replication-independent nucleosome assembly (GO:0006336)3.04224094
109kinetochore organization (GO:0051383)3.03927425
110DNA modification (GO:0006304)3.03572653
111DNA replication checkpoint (GO:0000076)3.03552791
112metaphase plate congression (GO:0051310)3.02405525
113DNA double-strand break processing (GO:0000729)3.01857499
114pore complex assembly (GO:0046931)3.01177550
115monoubiquitinated protein deubiquitination (GO:0035520)3.00936836
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00220211
117regulation of mitotic spindle checkpoint (GO:1903504)3.00220211
118heterochromatin organization (GO:0070828)2.95751811
119negative regulation of dendrite morphogenesis (GO:0050774)2.95382327
120oocyte development (GO:0048599)2.93782943
121protein polyglutamylation (GO:0018095)2.93721143
122DNA replication-dependent nucleosome organization (GO:0034723)2.91687202
123DNA replication-dependent nucleosome assembly (GO:0006335)2.91687202
124organelle fission (GO:0048285)2.91461064
125regulation of chromosome segregation (GO:0051983)2.91384773
126multicellular organismal reproductive process (GO:0048609)2.91270853
127sex differentiation (GO:0007548)2.89898948
128negative regulation of mitosis (GO:0045839)2.87527492
129chaperone-mediated protein complex assembly (GO:0051131)2.83633102
130chromosome organization (GO:0051276)2.82586022
131negative regulation of organelle assembly (GO:1902116)2.80578034
132negative regulation of nuclear division (GO:0051784)2.79788088
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78440064
134genitalia morphogenesis (GO:0035112)2.78249557
135telomere maintenance via semi-conservative replication (GO:0032201)2.77033341
136negative regulation of chromosome segregation (GO:0051985)2.76431626
137double-strand break repair via nonhomologous end joining (GO:0006303)2.76373046
138non-recombinational repair (GO:0000726)2.76373046
139mitotic sister chromatid cohesion (GO:0007064)2.75700611
140regulation of microtubule-based movement (GO:0060632)2.75102936
141DNA catabolic process, exonucleolytic (GO:0000738)2.74405159
142IMP biosynthetic process (GO:0006188)2.73008545
143anterior/posterior axis specification, embryo (GO:0008595)2.72991407
144protein K11-linked ubiquitination (GO:0070979)2.72454488
145embryonic body morphogenesis (GO:0010172)2.69324432
146IMP metabolic process (GO:0046040)2.61967907
147regulation of posttranscriptional gene silencing (GO:0060147)2.60267218
148regulation of gene silencing by miRNA (GO:0060964)2.60267218
149regulation of gene silencing by RNA (GO:0060966)2.60267218
150piRNA metabolic process (GO:0034587)14.1380953
151synaptonemal complex assembly (GO:0007130)10.8201428
152DNA methylation involved in gamete generation (GO:0043046)10.5264769
153synaptonemal complex organization (GO:0070193)10.4395326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.77345998
2E2F7_22180533_ChIP-Seq_HELA_Human3.76773156
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75977455
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.69984165
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.46264751
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.99841354
7EZH2_22144423_ChIP-Seq_EOC_Human2.87257558
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57118475
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49036622
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.42419913
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28365646
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25222413
13RNF2_27304074_Chip-Seq_NSC_Mouse2.23922296
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19608931
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15182081
16FUS_26573619_Chip-Seq_HEK293_Human2.12079758
17AR_21909140_ChIP-Seq_LNCAP_Human2.06564104
18ELK1_19687146_ChIP-ChIP_HELA_Human2.06438613
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.02642140
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00376226
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87718737
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.86463941
23EWS_26573619_Chip-Seq_HEK293_Human1.82182128
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.79848201
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.76792812
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74091060
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73446043
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70333495
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68455314
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68382752
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59780965
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59753744
33P300_19829295_ChIP-Seq_ESCs_Human1.57051668
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56889052
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55504599
36BCAT_22108803_ChIP-Seq_LS180_Human1.53307850
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.52882836
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.51746376
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50227207
40KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49944946
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49106373
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42798169
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.38952884
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37704360
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36020808
46ER_23166858_ChIP-Seq_MCF-7_Human1.35102441
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.33988725
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33939138
49GATA3_21867929_ChIP-Seq_TH1_Mouse1.32388937
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.32159758
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.29862254
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28692518
53FOXP3_21729870_ChIP-Seq_TREG_Human1.28207972
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24994942
55TP53_22573176_ChIP-Seq_HFKS_Human1.23657264
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23319532
57GABP_19822575_ChIP-Seq_HepG2_Human1.20333314
58TAF15_26573619_Chip-Seq_HEK293_Human1.18455353
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18373233
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17436559
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17058872
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16977528
63VDR_23849224_ChIP-Seq_CD4+_Human1.16853757
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16060007
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15735279
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14838560
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14452162
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11809585
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11551897
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.11062935
71DCP1A_22483619_ChIP-Seq_HELA_Human1.10863135
72GBX2_23144817_ChIP-Seq_PC3_Human1.10562278
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10420950
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10086332
75SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09488896
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09056548
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08844470
78MYC_18940864_ChIP-ChIP_HL60_Human1.08469307
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08358255
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.07391130
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07391130
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06690476
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06684588
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06066244
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05657961
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.03473249
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.03295303
88NANOG_19829295_ChIP-Seq_ESCs_Human1.03218709
89SOX2_19829295_ChIP-Seq_ESCs_Human1.03218709
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03041115
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01499550
92STAT1_17558387_ChIP-Seq_HELA_Human1.01400824
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00837013
94ZNF274_21170338_ChIP-Seq_K562_Hela1.00808758
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00632682
96RUNX2_22187159_ChIP-Seq_PCA_Human0.99872824
97IRF1_19129219_ChIP-ChIP_H3396_Human0.99816316
98TCF4_23295773_ChIP-Seq_U87_Human0.99776165
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99201995
100MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98769060
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98625921
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98625921
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98625921
104MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98502861
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98216457
106CBP_20019798_ChIP-Seq_JUKART_Human0.97126162
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97126162
108THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96696054
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96187899
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95655165
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95462941
112IGF1R_20145208_ChIP-Seq_DFB_Human0.95379918
113REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95197727
114ETV1_20927104_ChIP-Seq_GIST48_Human0.93799404
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.93777924
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93715794
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.93330591
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92870307
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92349283
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92204639
121TTF2_22483619_ChIP-Seq_HELA_Human0.91825387
122TCF4_22108803_ChIP-Seq_LS180_Human0.91635331
123FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91565163
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91090077
125XRN2_22483619_ChIP-Seq_HELA_Human0.90210057
126GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.90009387
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89537641
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89359853
129NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88596458
130SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87839730
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87556892
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86909848
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.86687269
134VDR_22108803_ChIP-Seq_LS180_Human0.86640133
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86075755
136CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82803105
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82150513
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81874334
139CDX2_22108803_ChIP-Seq_LS180_Human0.81438954
140STAT3_23295773_ChIP-Seq_U87_Human0.81252066
141HTT_18923047_ChIP-ChIP_STHdh_Human0.81221770
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.81148121
143YY1_21170310_ChIP-Seq_MESCs_Mouse0.80771985
144FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80737267
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80360790
146SMAD4_21799915_ChIP-Seq_A2780_Human0.80151491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.45333926
2MP0005410_abnormal_fertilization5.70661837
3MP0001929_abnormal_gametogenesis4.51188116
4MP0002210_abnormal_sex_determination4.39247581
5MP0008995_early_reproductive_senescence4.36447098
6MP0003698_abnormal_male_reproductive3.96346845
7MP0001145_abnormal_male_reproductive3.49422197
8MP0002735_abnormal_chemical_nociception3.41088448
9MP0010094_abnormal_chromosome_stability3.39617050
10MP0000653_abnormal_sex_gland3.28684162
11MP0003786_premature_aging3.09689601
12MP0003693_abnormal_embryo_hatching2.90406139
13MP0008058_abnormal_DNA_repair2.79062178
14MP0002161_abnormal_fertility/fecundity2.45745230
15MP0003011_delayed_dark_adaptation2.38687268
16MP0000383_abnormal_hair_follicle2.32463549
17MP0003941_abnormal_skin_development2.28340329
18MP0003718_maternal_effect2.27169179
19MP0008057_abnormal_DNA_replication2.19247984
20MP0003111_abnormal_nucleus_morphology2.16379349
21MP0001986_abnormal_taste_sensitivity2.11026436
22MP0004270_analgesia2.04948483
23MP0003123_paternal_imprinting2.03414745
24MP0008932_abnormal_embryonic_tissue1.98687215
25MP0003077_abnormal_cell_cycle1.98495857
26MP0002160_abnormal_reproductive_system1.95728330
27MP0002653_abnormal_ependyma_morphology1.90642384
28MP0004957_abnormal_blastocyst_morpholog1.89243478
29MP0002736_abnormal_nociception_after1.79026503
30MP0006035_abnormal_mitochondrial_morpho1.74004830
31MP0003136_yellow_coat_color1.68324566
32MP0010678_abnormal_skin_adnexa1.68122575
33MP0003646_muscle_fatigue1.65074219
34MP0008789_abnormal_olfactory_epithelium1.61504624
35MP0001119_abnormal_female_reproductive1.60662661
36MP0006276_abnormal_autonomic_nervous1.60378513
37MP0001968_abnormal_touch/_nociception1.55261034
38MP0003119_abnormal_digestive_system1.53802449
39MP0006072_abnormal_retinal_apoptosis1.53324872
40MP0002254_reproductive_system_inflammat1.46489956
41MP0005389_reproductive_system_phenotype1.45950965
42MP0001730_embryonic_growth_arrest1.45025275
43MP0006292_abnormal_olfactory_placode1.43182661
44MP0002734_abnormal_mechanical_nocicepti1.41455847
45MP0003699_abnormal_female_reproductive1.41288213
46MP0002102_abnormal_ear_morphology1.36811474
47MP0005253_abnormal_eye_physiology1.35466626
48MP0003315_abnormal_perineum_morphology1.34794890
49MP0004147_increased_porphyrin_level1.28926903
50MP0004858_abnormal_nervous_system1.28331668
51MP0002733_abnormal_thermal_nociception1.27889208
52MP0002638_abnormal_pupillary_reflex1.25075580
53MP0005174_abnormal_tail_pigmentation1.15481058
54MP0001919_abnormal_reproductive_system1.11011857
55MP0005499_abnormal_olfactory_system1.09776258
56MP0005394_taste/olfaction_phenotype1.09776258
57MP0001661_extended_life_span1.09477766
58MP0000647_abnormal_sebaceous_gland1.07125998
59MP0008007_abnormal_cellular_replicative1.06773780
60MP0009046_muscle_twitch1.05730584
61MP0005551_abnormal_eye_electrophysiolog1.05481984
62MP0008260_abnormal_autophagy1.03532439
63MP0002751_abnormal_autonomic_nervous1.01455070
64MP0001970_abnormal_pain_threshold1.00931075
65MP0003890_abnormal_embryonic-extraembry1.00719743
66MP0005647_abnormal_sex_gland1.00202156
67MP0000350_abnormal_cell_proliferation0.95900197
68MP0003121_genomic_imprinting0.95069583
69MP0004019_abnormal_vitamin_homeostasis0.94542112
70MP0001764_abnormal_homeostasis0.93094861
71MP0000955_abnormal_spinal_cord0.88793676
72MP0005365_abnormal_bile_salt0.87911345
73MP0005395_other_phenotype0.87851410
74MP0002184_abnormal_innervation0.87524419
75MP0003879_abnormal_hair_cell0.87037393
76MP0010307_abnormal_tumor_latency0.86505663
77MP0002837_dystrophic_cardiac_calcinosis0.86137586
78MP0005623_abnormal_meninges_morphology0.83839190
79MP0001697_abnormal_embryo_size0.81588025
80MP0003787_abnormal_imprinting0.81386226
81MP0001348_abnormal_lacrimal_gland0.80848941
82MP0005084_abnormal_gallbladder_morpholo0.78020912
83MP0000678_abnormal_parathyroid_gland0.75220277
84MP0002085_abnormal_embryonic_tissue0.74598533
85MP0001486_abnormal_startle_reflex0.73047147
86MP0003186_abnormal_redox_activity0.72340441
87MP0001529_abnormal_vocalization0.71774897
88MP0006036_abnormal_mitochondrial_physio0.71710890
89MP0000569_abnormal_digit_pigmentation0.70378834
90MP0001293_anophthalmia0.69998456
91MP0009697_abnormal_copulation0.68387917
92MP0001485_abnormal_pinna_reflex0.68314163
93MP0001849_ear_inflammation0.68288162
94MP0003195_calcinosis0.68129789
95MP0002084_abnormal_developmental_patter0.67865161
96MP0000313_abnormal_cell_death0.67077999
97MP0001324_abnormal_eye_pigmentation0.66400166
98MP0002938_white_spotting0.66265862
99MP0001672_abnormal_embryogenesis/_devel0.65586237
100MP0005380_embryogenesis_phenotype0.65586237
101MP0005075_abnormal_melanosome_morpholog0.65271550
102MP0004811_abnormal_neuron_physiology0.65269266
103MP0004215_abnormal_myocardial_fiber0.64651733
104MP0000013_abnormal_adipose_tissue0.63882227
105MP0005379_endocrine/exocrine_gland_phen0.62330017
106MP0002233_abnormal_nose_morphology0.61878078
107MP0003137_abnormal_impulse_conducting0.61480071
108MP0005085_abnormal_gallbladder_physiolo0.60858934
109MP0002067_abnormal_sensory_capabilities0.60612981
110MP0004133_heterotaxia0.60370890
111MP0002080_prenatal_lethality0.59990329
112MP0000631_abnormal_neuroendocrine_gland0.59680091
113MP0003943_abnormal_hepatobiliary_system0.58320854
114MP0004808_abnormal_hematopoietic_stem0.55987802
115MP0005408_hypopigmentation0.55729133
116MP0003878_abnormal_ear_physiology0.55061490
117MP0005377_hearing/vestibular/ear_phenot0.55061490
118MP0003122_maternal_imprinting0.54891312
119MP0002269_muscular_atrophy0.54693482
120MP0002229_neurodegeneration0.53536676
121MP0004036_abnormal_muscle_relaxation0.53362164
122MP0003880_abnormal_central_pattern0.52765402
123MP0002272_abnormal_nervous_system0.52470100
124MP0002019_abnormal_tumor_incidence0.52312909
125MP0000427_abnormal_hair_cycle0.52290452
126MP0003861_abnormal_nervous_system0.51187286
127MP0004859_abnormal_synaptic_plasticity0.49827784
128MP0003984_embryonic_growth_retardation0.49477231
129MP0002752_abnormal_somatic_nervous0.49271885
130MP0003936_abnormal_reproductive_system0.48599271
131MP0009672_abnormal_birth_weight0.46245727
132MP0000358_abnormal_cell_content/0.44612330
133MP0000534_abnormal_ureter_morphology0.44538946
134MP0000579_abnormal_nail_morphology0.44161756
135MP0001188_hyperpigmentation0.43132664
136MP0002088_abnormal_embryonic_growth/wei0.43104510
137MP0004145_abnormal_muscle_electrophysio0.42846404
138MP0003937_abnormal_limbs/digits/tail_de0.41147742
139MP0001963_abnormal_hearing_physiology0.39755899
140MP0003567_abnormal_fetal_cardiomyocyte0.39353384
141MP0009703_decreased_birth_body0.39126671
142MP0002882_abnormal_neuron_morphology0.38313649
143MP0001984_abnormal_olfaction0.37194756
144MP0000015_abnormal_ear_pigmentation0.36979430

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.46604408
2Azoospermia (HP:0000027)7.08489552
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.59180423
4Absent/shortened dynein arms (HP:0200106)6.59180423
5Abnormal spermatogenesis (HP:0008669)6.45704810
6Abnormal respiratory motile cilium physiology (HP:0012261)5.55043423
7Abnormality of the lower motor neuron (HP:0002366)5.28214149
8Rhinitis (HP:0012384)4.87414225
9Chronic bronchitis (HP:0004469)4.71093478
10Abnormal respiratory epithelium morphology (HP:0012253)4.63207763
11Abnormal respiratory motile cilium morphology (HP:0005938)4.63207763
12Infertility (HP:0000789)4.56298953
13Colon cancer (HP:0003003)4.54714855
14Myokymia (HP:0002411)4.36094026
15Volvulus (HP:0002580)4.29559177
16Horizontal nystagmus (HP:0000666)4.25344899
17Gonadotropin excess (HP:0000837)4.10133531
18Type I transferrin isoform profile (HP:0003642)4.07333893
19Abnormal ciliary motility (HP:0012262)4.01885301
20Ulnar claw (HP:0001178)3.70853792
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.68488626
22Abnormal protein N-linked glycosylation (HP:0012347)3.68488626
23Abnormal protein glycosylation (HP:0012346)3.68488626
24Abnormal glycosylation (HP:0012345)3.68488626
25Papillary thyroid carcinoma (HP:0002895)3.57898382
26Male infertility (HP:0003251)3.56304106
27Ependymoma (HP:0002888)3.29871576
28Impulsivity (HP:0100710)3.22104622
29Chromsome breakage (HP:0040012)3.14752114
30Supernumerary spleens (HP:0009799)3.14282523
31Degeneration of anterior horn cells (HP:0002398)3.13457131
32Abnormality of the anterior horn cell (HP:0006802)3.13457131
33Amyotrophic lateral sclerosis (HP:0007354)3.00641989
34Agnosia (HP:0010524)2.88260048
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81894145
36Thyroid carcinoma (HP:0002890)2.81372037
37Rimmed vacuoles (HP:0003805)2.81342542
38Nasal polyposis (HP:0100582)2.81135861
39Upper motor neuron abnormality (HP:0002127)2.77482913
40Facial hemangioma (HP:0000329)2.68187806
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.63718498
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.63718498
43Bronchiectasis (HP:0002110)2.58947874
44Biliary tract neoplasm (HP:0100574)2.58734672
45Embryonal renal neoplasm (HP:0011794)2.54251534
46Nephronophthisis (HP:0000090)2.47731675
47Short tibia (HP:0005736)2.46440982
48Methylmalonic aciduria (HP:0012120)2.43799032
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.42625560
50Abnormality of the labia minora (HP:0012880)2.41153288
51Carpal bone hypoplasia (HP:0001498)2.40766253
52Scotoma (HP:0000575)2.37852830
53Impaired vibration sensation in the lower limbs (HP:0002166)2.33748568
54Medial flaring of the eyebrow (HP:0010747)2.31754689
55Bronchitis (HP:0012387)2.28550906
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25631200
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.24768215
58Abnormality of the astrocytes (HP:0100707)2.21223132
59Astrocytoma (HP:0009592)2.21223132
60Acute necrotizing encephalopathy (HP:0006965)2.17890994
61Duodenal stenosis (HP:0100867)2.16192666
62Abnormal lung lobation (HP:0002101)2.15179106
63Impaired proprioception (HP:0010831)2.12202238
64Poor coordination (HP:0002370)2.07265588
65Abnormality of chromosome stability (HP:0003220)2.06768351
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.06704409
67Fibular hypoplasia (HP:0003038)2.01836323
68Glioma (HP:0009733)2.01683919
69Large hands (HP:0001176)2.01454420
70Abnormality of the nasal mucosa (HP:0000433)2.00847101
71Tongue fasciculations (HP:0001308)2.00132125
72Abnormal biliary tract physiology (HP:0012439)1.99724913
73Bile duct proliferation (HP:0001408)1.99724913
74Central scotoma (HP:0000603)1.99366053
75Microglossia (HP:0000171)1.99198100
76Neoplasm of the colon (HP:0100273)1.98777316
77Abnormality of the duodenum (HP:0002246)1.98422287
78Shoulder girdle muscle weakness (HP:0003547)1.98319790
79Capillary hemangiomas (HP:0005306)1.95660459
80Decreased motor nerve conduction velocity (HP:0003431)1.95571839
81Acute encephalopathy (HP:0006846)1.95534824
82Non-midline cleft lip (HP:0100335)1.95249915
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95078166
84Rhabdomyosarcoma (HP:0002859)1.94814435
85Abnormal hair whorl (HP:0010721)1.93002335
86Methylmalonic acidemia (HP:0002912)1.92536190
87Gait imbalance (HP:0002141)1.92277951
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.91972144
89Hyperglycinuria (HP:0003108)1.91377703
90Congenital primary aphakia (HP:0007707)1.91031627
91Meckel diverticulum (HP:0002245)1.90837413
92Action tremor (HP:0002345)1.90318518
93Muscle fibrillation (HP:0010546)1.90276657
94Genetic anticipation (HP:0003743)1.90248788
95Hyperventilation (HP:0002883)1.89384358
96Abnormality of the corticospinal tract (HP:0002492)1.89186596
97Abnormality of the vocal cords (HP:0008777)1.87359831
98Genital tract atresia (HP:0001827)1.87133123
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87009015
100Abolished electroretinogram (ERG) (HP:0000550)1.86043775
101Areflexia of lower limbs (HP:0002522)1.85572257
102Impaired vibratory sensation (HP:0002495)1.85528763
103Hyperglycinemia (HP:0002154)1.85267775
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84655091
105Abnormality of alanine metabolism (HP:0010916)1.84655091
106Hyperalaninemia (HP:0003348)1.84655091
107Abnormality of glycine metabolism (HP:0010895)1.83779814
108Abnormality of serine family amino acid metabolism (HP:0010894)1.83779814
109Gaze-evoked nystagmus (HP:0000640)1.83229224
110Premature ovarian failure (HP:0008209)1.81310483
111Abnormality of serum amino acid levels (HP:0003112)1.80474360
112Spontaneous abortion (HP:0005268)1.79101063
113Pancreatic fibrosis (HP:0100732)1.78842310
114Pancreatic cysts (HP:0001737)1.78008454
115Abnormality of the renal medulla (HP:0100957)1.77683894
116Progressive inability to walk (HP:0002505)1.77084649
117Osteomalacia (HP:0002749)1.76375444
118Absent thumb (HP:0009777)1.76337438
119Preaxial hand polydactyly (HP:0001177)1.76172687
120Abnormal mitochondria in muscle tissue (HP:0008316)1.75740757
121Delusions (HP:0000746)1.75624887
122Foot dorsiflexor weakness (HP:0009027)1.75325292
123Neoplasm of striated muscle (HP:0009728)1.75146087
124Abnormality of the ileum (HP:0001549)1.74988604
125Astigmatism (HP:0000483)1.73971683
126Urinary bladder sphincter dysfunction (HP:0002839)1.73686681
127Sandal gap (HP:0001852)1.73265444
128Abnormality of the foot musculature (HP:0001436)1.73090531
129Segmental peripheral demyelination/remyelination (HP:0003481)1.72683296
130Medulloblastoma (HP:0002885)1.72032918
131Distal sensory impairment (HP:0002936)1.71971656
132Tubulointerstitial nephritis (HP:0001970)1.71944875
133Abnormality of the epiphysis of the femoral head (HP:0010574)1.71895769
134Progressive macrocephaly (HP:0004481)1.71859805
135Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.71575574
136Heterotopia (HP:0002282)1.71348255
137Shawl scrotum (HP:0000049)1.71233568
138Progressive external ophthalmoplegia (HP:0000590)1.70959555
139Increased CSF lactate (HP:0002490)1.70541796
140Abnormal biliary tract morphology (HP:0012440)1.69703566
141Ectopic kidney (HP:0000086)1.69342239
142Urinary urgency (HP:0000012)1.68189186
143Broad foot (HP:0001769)1.67764730
144Birth length less than 3rd percentile (HP:0003561)1.67054065
145Inability to walk (HP:0002540)1.66915933
146Steppage gait (HP:0003376)1.66523683
147Breast carcinoma (HP:0003002)1.66282002
148Dysdiadochokinesis (HP:0002075)1.66087493
149Vaginal atresia (HP:0000148)1.65749365
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65046091
151Absent epiphyses (HP:0010577)1.65046091
152Oligodactyly (hands) (HP:0001180)1.64167772
153Nephroblastoma (Wilms tumor) (HP:0002667)1.63994678
154Facial cleft (HP:0002006)1.63725386
155Abnormality of the preputium (HP:0100587)1.63052060
156Breast hypoplasia (HP:0003187)1.62833321
157Myotonia (HP:0002486)1.62815398
158Abnormality of the phalanges of the hallux (HP:0010057)1.62745643
159Sloping forehead (HP:0000340)1.62166844
160Termporal pattern (HP:0011008)1.61069608
161Insidious onset (HP:0003587)1.61069608
162Fetal akinesia sequence (HP:0001989)1.60353178
163Overlapping toe (HP:0001845)1.60094486
164Nephrogenic diabetes insipidus (HP:0009806)1.59542366
165Small intestinal stenosis (HP:0012848)1.58927461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.58171312
2PDK35.58171312
3CDK194.37531158
4CDC74.00068862
5ACVR1B3.68479673
6MET3.67975784
7PDK23.25356994
8OXSR12.58675112
9PLK42.55980869
10STK38L2.33246045
11BMX2.31700900
12CAMK1G2.26226946
13PRKD32.19902935
14FGR2.16692727
15LMTK22.12621822
16NUAK12.11478365
17NEK22.06991371
18TTK2.04307542
19LATS21.94565220
20CDK121.93039726
21ZAK1.92468934
22WEE11.92047338
23NTRK31.88540156
24MAP4K21.88227625
25TSSK61.82914453
26MAP3K41.82078989
27MAPKAPK31.78914422
28TESK11.78686425
29MAP3K91.78530035
30NEK11.78191484
31LATS11.71204321
32BRSK21.67841432
33PLK11.65410199
34MINK11.63024853
35FRK1.51000576
36CSF1R1.50210615
37PNCK1.47224944
38BUB11.40231769
39BRAF1.39901728
40GRK51.39681827
41MAP2K71.38881930
42KSR21.38240167
43WNK41.34257033
44STK391.33309131
45MKNK11.32107963
46TAF11.31881875
47WNK31.28669638
48MST41.21337696
49MAPK131.18486695
50CHEK21.18115107
51MAP3K21.16549232
52EIF2AK11.13856159
53WNK11.13204591
54LIMK11.12185056
55TRIM281.12153221
56BRSK11.09350582
57VRK21.08463518
58BMPR1B1.06876690
59CHEK11.03137830
60AURKA1.02768774
61MAP3K61.02590820
62CCNB11.02429040
63NME11.01205156
64STK160.99709596
65VRK10.98831650
66STK240.98445528
67MAP2K40.97627425
68STK30.95239115
69SCYL20.92855753
70DYRK30.90835169
71PBK0.89435860
72PRKCI0.86362005
73PLK20.85654128
74CDK30.83890242
75ATM0.82445932
76NEK90.80503483
77PASK0.78855859
78CASK0.77072494
79ATR0.74922822
80TNIK0.74684806
81EGFR0.74653370
82PTK2B0.73356675
83STK380.72774128
84PLK30.72589866
85GRK10.72390141
86CDK80.71142057
87CSNK1G10.71101505
88PDGFRB0.70120956
89MUSK0.67560735
90ERBB40.66357344
91ADRBK20.66281042
92MELK0.65568993
93CSNK1G20.64805520
94CDK60.63252761
95TIE10.62681310
96PINK10.61111398
97BCR0.60862030
98NLK0.58886461
99SIK30.58239229
100AURKB0.57372968
101RET0.57215113
102SGK20.56503630
103TESK20.55417646
104PTK20.52333268
105MKNK20.51271324
106ARAF0.50836089
107CDK10.50619969
108PAK30.48406087
109CDK70.48193538
110KSR10.47553015
111EIF2AK30.46838706
112CDK20.46683976
113CSNK1E0.45898715
114YES10.45598464
115SRPK10.45383289
116MAP3K100.43174122
117CDK11A0.42763539
118NEK60.39003549
119ICK0.38658342
120PRKCE0.38190573
121CSNK2A10.37938888
122RPS6KB20.37784114
123TYRO30.37556108
124CSNK1G30.37362856
125DYRK1A0.36564966
126PDK10.35434280
127PRKDC0.34971534
128MARK30.34759365
129AKT30.30604649
130MAP2K10.30602792
131PHKG10.30571586
132PHKG20.30571586
133SGK4940.29664826
134SGK2230.29664826
135PAK60.28910724
136CAMK10.28842463
137CSNK1A1L0.28828255
138CSNK2A20.28359259
139PRKAA10.28023330
140GSK3B0.27945976
141DYRK20.27820062
142MAPK80.27311388
143FER0.27146039
144PRKACB0.26852187
145RPS6KB10.26269982
146TAOK10.26210061
147EPHA40.26122231
148STK110.26113919
149MAPK100.25664865
150BMPR20.23871302
151CAMK2A0.22621512
152PRKCG0.21399600

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.80101284
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.39482310
3Homologous recombination_Homo sapiens_hsa034403.25583144
4Proteasome_Homo sapiens_hsa030503.19464796
5Oocyte meiosis_Homo sapiens_hsa041143.19180414
6RNA transport_Homo sapiens_hsa030133.07086905
7Cell cycle_Homo sapiens_hsa041102.87423734
8Vitamin B6 metabolism_Homo sapiens_hsa007502.76490068
9Fanconi anemia pathway_Homo sapiens_hsa034602.75086966
10RNA polymerase_Homo sapiens_hsa030202.59314548
11Dorso-ventral axis formation_Homo sapiens_hsa043202.50357873
12Huntingtons disease_Homo sapiens_hsa050162.45025956
13Mismatch repair_Homo sapiens_hsa034302.35763110
14Protein export_Homo sapiens_hsa030602.20904027
15DNA replication_Homo sapiens_hsa030302.16740940
16Pyruvate metabolism_Homo sapiens_hsa006202.13026492
17mRNA surveillance pathway_Homo sapiens_hsa030152.02097837
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.97148935
19RNA degradation_Homo sapiens_hsa030181.85916951
20Non-homologous end-joining_Homo sapiens_hsa034501.81541472
21Nucleotide excision repair_Homo sapiens_hsa034201.73508409
22Selenocompound metabolism_Homo sapiens_hsa004501.68563770
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62523877
24Pyrimidine metabolism_Homo sapiens_hsa002401.59391419
25Base excision repair_Homo sapiens_hsa034101.55596305
26Parkinsons disease_Homo sapiens_hsa050121.52634828
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47480000
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41379195
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40555206
30Oxidative phosphorylation_Homo sapiens_hsa001901.37391569
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.36453706
32Spliceosome_Homo sapiens_hsa030401.36172080
33Purine metabolism_Homo sapiens_hsa002301.34617212
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.33585649
35Thyroid cancer_Homo sapiens_hsa052161.25495537
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22955759
37N-Glycan biosynthesis_Homo sapiens_hsa005101.22657682
38Epstein-Barr virus infection_Homo sapiens_hsa051691.19141945
39Phototransduction_Homo sapiens_hsa047441.15935463
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14945687
41Glucagon signaling pathway_Homo sapiens_hsa049221.12549212
42Linoleic acid metabolism_Homo sapiens_hsa005911.11523838
43beta-Alanine metabolism_Homo sapiens_hsa004101.10457638
44Cardiac muscle contraction_Homo sapiens_hsa042601.05834263
45Synaptic vesicle cycle_Homo sapiens_hsa047211.05721374
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05365261
47Fatty acid elongation_Homo sapiens_hsa000621.04579726
48Regulation of autophagy_Homo sapiens_hsa041400.97828489
49Retinol metabolism_Homo sapiens_hsa008300.95527935
50Pentose phosphate pathway_Homo sapiens_hsa000300.93712866
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92388989
52Alzheimers disease_Homo sapiens_hsa050100.89515476
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89245796
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88572507
55p53 signaling pathway_Homo sapiens_hsa041150.85186932
56Long-term potentiation_Homo sapiens_hsa047200.85036254
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84765260
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84689633
59Steroid biosynthesis_Homo sapiens_hsa001000.81890552
60Caffeine metabolism_Homo sapiens_hsa002320.81009352
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81001320
62Ether lipid metabolism_Homo sapiens_hsa005650.76253284
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.76185559
64Propanoate metabolism_Homo sapiens_hsa006400.71728927
65Glycerolipid metabolism_Homo sapiens_hsa005610.70367172
66Vitamin digestion and absorption_Homo sapiens_hsa049770.67245832
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.64951621
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63937971
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63435120
70Sphingolipid metabolism_Homo sapiens_hsa006000.59277311
71Olfactory transduction_Homo sapiens_hsa047400.57965431
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57894576
73Sulfur relay system_Homo sapiens_hsa041220.55679105
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55558888
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54234617
76Taste transduction_Homo sapiens_hsa047420.53389386
77Arginine and proline metabolism_Homo sapiens_hsa003300.53132719
78Nitrogen metabolism_Homo sapiens_hsa009100.52943161
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.52724918
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52026572
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.51721341
82Peroxisome_Homo sapiens_hsa041460.51294608
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50824924
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50319300
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49835769
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49011251
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48777864
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47854156
89Nicotine addiction_Homo sapiens_hsa050330.45838212
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45035073
91Amphetamine addiction_Homo sapiens_hsa050310.42436274
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.41872414
93Lysine degradation_Homo sapiens_hsa003100.41315807
94One carbon pool by folate_Homo sapiens_hsa006700.41146547
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.41071125
96VEGF signaling pathway_Homo sapiens_hsa043700.40295851
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.39371951
98TGF-beta signaling pathway_Homo sapiens_hsa043500.39112869
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38250375
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37241739
101Ovarian steroidogenesis_Homo sapiens_hsa049130.36842789
102Biosynthesis of amino acids_Homo sapiens_hsa012300.35976801
103Fatty acid degradation_Homo sapiens_hsa000710.35729764
104Chemical carcinogenesis_Homo sapiens_hsa052040.35616655
105Fatty acid metabolism_Homo sapiens_hsa012120.35447199
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34560728
107Hedgehog signaling pathway_Homo sapiens_hsa043400.33950523
108Dopaminergic synapse_Homo sapiens_hsa047280.33787057
109Collecting duct acid secretion_Homo sapiens_hsa049660.33267306
110Insulin signaling pathway_Homo sapiens_hsa049100.31463459
111Tryptophan metabolism_Homo sapiens_hsa003800.31233277
112Metabolic pathways_Homo sapiens_hsa011000.30867886
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27649039
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27329565
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27222285
116Viral carcinogenesis_Homo sapiens_hsa052030.27047974
117Butanoate metabolism_Homo sapiens_hsa006500.26676390
118Fatty acid biosynthesis_Homo sapiens_hsa000610.26650659
119Inositol phosphate metabolism_Homo sapiens_hsa005620.26643534
120Hippo signaling pathway_Homo sapiens_hsa043900.25950380
121GnRH signaling pathway_Homo sapiens_hsa049120.25878361
122Arachidonic acid metabolism_Homo sapiens_hsa005900.25166871
123Estrogen signaling pathway_Homo sapiens_hsa049150.24579292
124Colorectal cancer_Homo sapiens_hsa052100.22177052
125ErbB signaling pathway_Homo sapiens_hsa040120.22010122
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21807742
127FoxO signaling pathway_Homo sapiens_hsa040680.21167260
128Wnt signaling pathway_Homo sapiens_hsa043100.20744663
129Fat digestion and absorption_Homo sapiens_hsa049750.20210525
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20135300
131HTLV-I infection_Homo sapiens_hsa051660.19879063
132Influenza A_Homo sapiens_hsa051640.19795653
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19717673
134Ribosome_Homo sapiens_hsa030100.19415283
135Endocytosis_Homo sapiens_hsa041440.18619277
136Glutathione metabolism_Homo sapiens_hsa004800.18307784
137Calcium signaling pathway_Homo sapiens_hsa040200.17330123
138Circadian rhythm_Homo sapiens_hsa047100.16207100
139Carbon metabolism_Homo sapiens_hsa012000.15682615
140Endometrial cancer_Homo sapiens_hsa052130.15467116
141Herpes simplex infection_Homo sapiens_hsa051680.14913971
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14745458
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14111685
144Prolactin signaling pathway_Homo sapiens_hsa049170.13822557
145Salmonella infection_Homo sapiens_hsa051320.13573466
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12590081
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.12060695

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