CCDC177

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.97688769
2vocalization behavior (GO:0071625)5.68349410
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.61807640
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.55946162
5protein localization to synapse (GO:0035418)5.45769541
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.35215505
7pyrimidine nucleobase catabolic process (GO:0006208)5.27833772
8synaptic vesicle exocytosis (GO:0016079)5.05288610
9regulation of glutamate receptor signaling pathway (GO:1900449)4.99205914
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.92906934
11neuron recognition (GO:0008038)4.89494224
12glutamate receptor signaling pathway (GO:0007215)4.89319569
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85275907
14glutamate secretion (GO:0014047)4.56893122
15dendritic spine morphogenesis (GO:0060997)4.53779842
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.53227943
17layer formation in cerebral cortex (GO:0021819)4.52411771
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45923952
19cell proliferation in forebrain (GO:0021846)4.44708165
20axonal fasciculation (GO:0007413)4.41422245
21regulation of synaptic vesicle exocytosis (GO:2000300)4.37050773
22locomotory exploration behavior (GO:0035641)4.35225360
23presynaptic membrane assembly (GO:0097105)4.27942553
24postsynaptic membrane organization (GO:0001941)4.27296852
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.26870955
26retinal ganglion cell axon guidance (GO:0031290)4.26551878
27synaptic transmission, glutamatergic (GO:0035249)4.21404653
28neuron-neuron synaptic transmission (GO:0007270)4.18026839
29nucleobase catabolic process (GO:0046113)4.12667354
30synaptic vesicle maturation (GO:0016188)4.11986159
31neurotransmitter-gated ion channel clustering (GO:0072578)4.06710484
32gamma-aminobutyric acid signaling pathway (GO:0007214)4.06542669
33positive regulation of synapse maturation (GO:0090129)4.02046319
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00841895
35response to histamine (GO:0034776)4.00529182
36exploration behavior (GO:0035640)4.00005358
37neuronal action potential propagation (GO:0019227)3.95962661
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92244130
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.87787688
40presynaptic membrane organization (GO:0097090)3.86472479
41regulation of postsynaptic membrane potential (GO:0060078)3.84932434
42neurotransmitter secretion (GO:0007269)3.83179620
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.81205588
44regulation of synaptic vesicle transport (GO:1902803)3.80204478
45positive regulation of membrane potential (GO:0045838)3.73031789
46positive regulation of synapse assembly (GO:0051965)3.71423038
47regulation of dendritic spine morphogenesis (GO:0061001)3.71049933
48regulation of neuronal synaptic plasticity (GO:0048168)3.67537041
49cerebral cortex radially oriented cell migration (GO:0021799)3.64375566
50central nervous system projection neuron axonogenesis (GO:0021952)3.64147070
51regulation of timing of cell differentiation (GO:0048505)3.64048607
52long-term synaptic potentiation (GO:0060291)3.62842868
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.61512176
54regulation of development, heterochronic (GO:0040034)3.61216473
55olfactory bulb development (GO:0021772)3.58798277
56positive regulation of neurotransmitter secretion (GO:0001956)3.56285992
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52268868
58intraciliary transport (GO:0042073)3.50124223
59synaptic vesicle endocytosis (GO:0048488)3.49126942
60long-term memory (GO:0007616)3.47118547
61ephrin receptor signaling pathway (GO:0048013)3.46661993
62transmission of nerve impulse (GO:0019226)3.44131738
63positive regulation of neurotransmitter transport (GO:0051590)3.43287543
64negative regulation of astrocyte differentiation (GO:0048712)3.42879276
65synapse assembly (GO:0007416)3.42363174
66regulation of synapse structural plasticity (GO:0051823)3.41913966
67appendage development (GO:0048736)3.37468198
68limb development (GO:0060173)3.37468198
69membrane hyperpolarization (GO:0060081)3.36545759
70innervation (GO:0060384)3.36366776
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36326966
72neurotransmitter transport (GO:0006836)3.34359111
73regulation of respiratory system process (GO:0044065)3.34342157
74dendritic spine organization (GO:0097061)3.32721165
75regulation of vesicle fusion (GO:0031338)3.32609217
76behavioral defense response (GO:0002209)3.32379318
77behavioral fear response (GO:0001662)3.32379318
78startle response (GO:0001964)3.31782923
79chaperone-mediated protein transport (GO:0072321)3.28860443
80regulation of synaptic plasticity (GO:0048167)3.27510521
81spinal cord association neuron differentiation (GO:0021527)3.27494350
82positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27124148
83substrate-independent telencephalic tangential migration (GO:0021826)3.26920086
84substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.26920086
85regulation of dendritic spine development (GO:0060998)3.26898559
86cell migration in hindbrain (GO:0021535)3.24038157
87regulation of synapse maturation (GO:0090128)3.23173428
88positive regulation of dendritic spine development (GO:0060999)3.22588406
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.22540688
90forebrain neuron differentiation (GO:0021879)3.21466562
91axon ensheathment in central nervous system (GO:0032291)3.21312377
92central nervous system myelination (GO:0022010)3.21312377
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20451747
94righting reflex (GO:0060013)3.18564288
95social behavior (GO:0035176)3.16859263
96intraspecies interaction between organisms (GO:0051703)3.16859263
97regulation of neurotransmitter secretion (GO:0046928)3.16369061
98fear response (GO:0042596)3.14761924
99dendrite morphogenesis (GO:0048813)3.13607888
100behavioral response to nicotine (GO:0035095)3.13078946
101negative regulation of microtubule polymerization (GO:0031115)3.12664789
102cellular potassium ion homeostasis (GO:0030007)3.11681413
103regulation of synapse assembly (GO:0051963)3.10761540
104regulation of glutamate secretion (GO:0014048)3.10494402
105membrane depolarization (GO:0051899)3.10383805
106behavioral response to cocaine (GO:0048148)3.08888035
107negative regulation of oligodendrocyte differentiation (GO:0048715)3.08753660
108auditory behavior (GO:0031223)3.07583480
109positive regulation of gastrulation (GO:2000543)3.07132989
110negative regulation of glial cell differentiation (GO:0045686)3.06221366
111dendrite development (GO:0016358)3.05928606
112learning (GO:0007612)3.04439003
113synapse organization (GO:0050808)3.04435526
114mechanosensory behavior (GO:0007638)3.02798217
115cerebellar granule cell differentiation (GO:0021707)3.02204708
116adult walking behavior (GO:0007628)3.02194473
117cerebral cortex neuron differentiation (GO:0021895)2.99439667
118proline transport (GO:0015824)2.99207214
119gamma-aminobutyric acid transport (GO:0015812)2.97085460
120regulation of rhodopsin mediated signaling pathway (GO:0022400)2.96452730
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96199933
122regulation of synapse organization (GO:0050807)2.95892802
123regulation of respiratory gaseous exchange (GO:0043576)2.94311443
124regulation of neurotransmitter levels (GO:0001505)2.93780283
125cerebellar Purkinje cell differentiation (GO:0021702)2.92294382
126prepulse inhibition (GO:0060134)2.91974918
127cochlea development (GO:0090102)2.91874271
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91052399
129retinal cone cell development (GO:0046549)2.90595966
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86916018
131regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.85928653
132regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.85928653
133tongue development (GO:0043586)2.85646125
134establishment of mitochondrion localization (GO:0051654)2.83910274
135nonmotile primary cilium assembly (GO:0035058)2.78735035
136spinal cord development (GO:0021510)2.77775196
137lateral sprouting from an epithelium (GO:0060601)2.74427549
138positive regulation of neuroblast proliferation (GO:0002052)2.74392268
139hindbrain development (GO:0030902)2.73895687
140peristalsis (GO:0030432)2.70139001
141camera-type eye morphogenesis (GO:0048593)2.68936841
142axonemal dynein complex assembly (GO:0070286)2.68496712
143pituitary gland development (GO:0021983)2.66647539
144hippocampus development (GO:0021766)2.63627602
145neuron fate determination (GO:0048664)2.63278516
146membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62643181
147smoothened signaling pathway (GO:0007224)2.62205163
148body morphogenesis (GO:0010171)2.60388998
149neural precursor cell proliferation (GO:0061351)2.59405736
150neuronal stem cell maintenance (GO:0097150)2.59252514
151short-term memory (GO:0007614)2.59040009
152limb bud formation (GO:0060174)2.55465967
153regulation of cilium movement (GO:0003352)2.54218156
154cell differentiation in spinal cord (GO:0021515)2.53772622
155myelin assembly (GO:0032288)2.52679324
156establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52460944
157mitochondrion transport along microtubule (GO:0047497)2.52460944
158otic vesicle formation (GO:0030916)2.50918716
159maturation of SSU-rRNA (GO:0030490)2.49319206
160viral transcription (GO:0019083)2.48900280
161sequestering of actin monomers (GO:0042989)2.48266903
162neuron migration (GO:0001764)2.45727075
163axon extension (GO:0048675)2.45182012
164central nervous system neuron axonogenesis (GO:0021955)2.45167014
165negative regulation of gliogenesis (GO:0014014)2.44163213
166anterograde axon cargo transport (GO:0008089)2.43536886
167striatum development (GO:0021756)2.43231704
168centriole replication (GO:0007099)2.41602783
169cerebral cortex development (GO:0021987)2.40493210
170somite development (GO:0061053)2.39877090
171translational termination (GO:0006415)2.39791777
172cardiovascular system development (GO:0072358)2.39671345
173thalamus development (GO:0021794)2.39053296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25551879
2GBX2_23144817_ChIP-Seq_PC3_Human4.02464935
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20470570
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.19539009
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04524808
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99646787
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.81309283
8REST_21632747_ChIP-Seq_MESCs_Mouse2.63420657
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61860549
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61860549
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61598385
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60320330
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60172027
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.41265885
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36065259
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.33920406
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33479737
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32377130
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31095843
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24670577
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.24498791
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.23527282
23TAF15_26573619_Chip-Seq_HEK293_Human2.23251170
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23167305
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23166451
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22118449
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19860895
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13721334
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12073259
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.05295719
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02962313
32DROSHA_22980978_ChIP-Seq_HELA_Human1.99186826
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.98824992
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.95983919
35AR_21572438_ChIP-Seq_LNCaP_Human1.91515105
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81925173
37EWS_26573619_Chip-Seq_HEK293_Human1.78129425
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76597262
39IGF1R_20145208_ChIP-Seq_DFB_Human1.74244116
40P300_19829295_ChIP-Seq_ESCs_Human1.73913860
41SMAD4_21799915_ChIP-Seq_A2780_Human1.72488973
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71770042
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71308547
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71032015
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65139090
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64873956
47ZNF274_21170338_ChIP-Seq_K562_Hela1.64292969
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63445470
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61829787
50FUS_26573619_Chip-Seq_HEK293_Human1.61129879
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57040024
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.56646916
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.55340216
54RNF2_27304074_Chip-Seq_NSC_Mouse1.54238461
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50505031
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50149804
57VDR_22108803_ChIP-Seq_LS180_Human1.46996282
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.46644015
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.45207006
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37609160
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.35619572
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.33213252
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32815272
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31439708
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29437687
66AR_25329375_ChIP-Seq_VCAP_Human1.27734261
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.26783013
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.25112123
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24538190
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.23954645
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23843877
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23672835
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23095384
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22707310
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22445883
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22225804
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22225804
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21228629
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20169632
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18317479
81STAT3_23295773_ChIP-Seq_U87_Human1.16515144
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15500636
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14948948
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14759304
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13511358
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13183007
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13142305
88IRF1_19129219_ChIP-ChIP_H3396_Human1.12244130
89TCF4_23295773_ChIP-Seq_U87_Human1.10886923
90AR_19668381_ChIP-Seq_PC3_Human1.10716887
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10159044
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.10151418
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.10087943
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09819802
95ER_23166858_ChIP-Seq_MCF-7_Human1.09509286
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.08199819
97BCAT_22108803_ChIP-Seq_LS180_Human1.08161349
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08002651
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07919407
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.07766199
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06149142
102RUNX2_22187159_ChIP-Seq_PCA_Human1.06088360
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.05735206
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05533518
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.04739948
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04716102
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03603089
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02723024
109AHR_22903824_ChIP-Seq_MCF-7_Human1.02032826
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.01218076
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01136539
112JUN_21703547_ChIP-Seq_K562_Human1.00333252
113ISL1_27105846_Chip-Seq_CPCs_Mouse1.00290039
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99969695
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99534458
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98561171
117TP53_18474530_ChIP-ChIP_U2OS_Human0.98351119
118TP53_16413492_ChIP-PET_HCT116_Human0.94685997
119KDM2B_26808549_Chip-Seq_REH_Human0.94660144
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94311430
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93949608
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93335034
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93026481
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.92760373
125SOX9_26525672_Chip-Seq_HEART_Mouse0.92181357
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91154712
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90823475
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.90467183
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90064867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.31262115
2MP0004859_abnormal_synaptic_plasticity5.23427599
3MP0000566_synostosis3.87805063
4MP0003635_abnormal_synaptic_transmissio3.79932036
5MP0004270_analgesia3.42822640
6MP0002063_abnormal_learning/memory/cond3.11282139
7MP0001968_abnormal_touch/_nociception3.10164807
8MP0009745_abnormal_behavioral_response3.06223802
9MP0005423_abnormal_somatic_nervous2.98869054
10MP0002064_seizures2.80547346
11MP0002572_abnormal_emotion/affect_behav2.69429764
12MP0009046_muscle_twitch2.68771715
13MP0002653_abnormal_ependyma_morphology2.60709368
14MP0002734_abnormal_mechanical_nocicepti2.60036441
15MP0002736_abnormal_nociception_after2.51203259
16MP0001486_abnormal_startle_reflex2.49351424
17MP0000778_abnormal_nervous_system2.48095469
18MP0003136_yellow_coat_color2.44806414
19MP0002272_abnormal_nervous_system2.41250640
20MP0005551_abnormal_eye_electrophysiolog2.35291815
21MP0003123_paternal_imprinting2.32412893
22MP0006276_abnormal_autonomic_nervous2.29553781
23MP0002735_abnormal_chemical_nociception2.19527231
24MP0001440_abnormal_grooming_behavior2.13385696
25MP0000049_abnormal_middle_ear2.04510957
26MP0001501_abnormal_sleep_pattern2.04285693
27MP0002067_abnormal_sensory_capabilities1.99350341
28MP0002184_abnormal_innervation1.96783567
29MP0001293_anophthalmia1.92713205
30MP0001188_hyperpigmentation1.92705940
31MP0008877_abnormal_DNA_methylation1.85025790
32MP0002733_abnormal_thermal_nociception1.84637065
33MP0006072_abnormal_retinal_apoptosis1.81049780
34MP0001984_abnormal_olfaction1.79791587
35MP0001970_abnormal_pain_threshold1.77555464
36MP0003890_abnormal_embryonic-extraembry1.74048944
37MP0001529_abnormal_vocalization1.71646528
38MP0002557_abnormal_social/conspecific_i1.71352147
39MP0004924_abnormal_behavior1.65354260
40MP0005386_behavior/neurological_phenoty1.65354260
41MP0010030_abnormal_orbit_morphology1.65342870
42MP0002882_abnormal_neuron_morphology1.57175898
43MP0004811_abnormal_neuron_physiology1.53422362
44MP0000428_abnormal_craniofacial_morphol1.52162735
45MP0002233_abnormal_nose_morphology1.51184965
46MP0000955_abnormal_spinal_cord1.48213314
47MP0002938_white_spotting1.46664378
48MP0005253_abnormal_eye_physiology1.44685869
49MP0003879_abnormal_hair_cell1.44261420
50MP0003937_abnormal_limbs/digits/tail_de1.42934802
51MP0009780_abnormal_chondrocyte_physiolo1.41677030
52MP0002909_abnormal_adrenal_gland1.41378728
53MP0005645_abnormal_hypothalamus_physiol1.38900627
54MP0003787_abnormal_imprinting1.36401211
55MP0006292_abnormal_olfactory_placode1.35101383
56MP0003329_amyloid_beta_deposits1.35089689
57MP0002822_catalepsy1.34051126
58MP0002066_abnormal_motor_capabilities/c1.32299137
59MP0001299_abnormal_eye_distance/1.31700344
60MP0004742_abnormal_vestibular_system1.31573826
61MP0001905_abnormal_dopamine_level1.31548908
62MP0001502_abnormal_circadian_rhythm1.31183687
63MP0001286_abnormal_eye_development1.28558575
64MP0004133_heterotaxia1.27285755
65MP0003122_maternal_imprinting1.27144437
66MP0008569_lethality_at_weaning1.26782063
67MP0002152_abnormal_brain_morphology1.24311209
68MP0005394_taste/olfaction_phenotype1.21226919
69MP0005499_abnormal_olfactory_system1.21226919
70MP0003942_abnormal_urinary_system1.18869202
71MP0004885_abnormal_endolymph1.18307484
72MP0004142_abnormal_muscle_tone1.16640447
73MP0002697_abnormal_eye_size1.16546511
74MP0002752_abnormal_somatic_nervous1.15907364
75MP0005646_abnormal_pituitary_gland1.15324854
76MP0000631_abnormal_neuroendocrine_gland1.13324674
77MP0009053_abnormal_anal_canal1.12203445
78MP0002837_dystrophic_cardiac_calcinosis1.10027467
79MP0002638_abnormal_pupillary_reflex1.09639538
80MP0002229_neurodegeneration1.09095401
81MP0002102_abnormal_ear_morphology1.07749753
82MP0000751_myopathy1.07703323
83MP0005409_darkened_coat_color1.07230709
84MP0004858_abnormal_nervous_system1.03812756
85MP0003755_abnormal_palate_morphology1.03589064
86MP0010386_abnormal_urinary_bladder1.01747944
87MP0004145_abnormal_muscle_electrophysio1.01442674
88MP0001963_abnormal_hearing_physiology0.98939918
89MP0005195_abnormal_posterior_eye0.98860689
90MP0000569_abnormal_digit_pigmentation0.98555700
91MP0003567_abnormal_fetal_cardiomyocyte0.97943132
92MP0001346_abnormal_lacrimal_gland0.95901196
93MP0009379_abnormal_foot_pigmentation0.95635871
94MP0002116_abnormal_craniofacial_bone0.93199944
95MP0002092_abnormal_eye_morphology0.90474031
96MP0003011_delayed_dark_adaptation0.90141812
97MP0000026_abnormal_inner_ear0.89164883
98MP0002069_abnormal_eating/drinking_beha0.89127813
99MP0003861_abnormal_nervous_system0.88713866
100MP0002090_abnormal_vision0.86640744
101MP0008789_abnormal_olfactory_epithelium0.86125928
102MP0001485_abnormal_pinna_reflex0.83506813
103MP0002234_abnormal_pharynx_morphology0.82942801
104MP0002210_abnormal_sex_determination0.82781025
105MP0004233_abnormal_muscle_weight0.81864249
106MP0005248_abnormal_Harderian_gland0.80195759
107MP0003633_abnormal_nervous_system0.80173296
108MP0009250_abnormal_appendicular_skeleto0.79412057
109MP0000579_abnormal_nail_morphology0.78874708
110MP0003935_abnormal_craniofacial_develop0.78420991
111MP0002282_abnormal_trachea_morphology0.78109223
112MP0002081_perinatal_lethality0.76948937
113MP0003693_abnormal_embryo_hatching0.76186451
114MP0004085_abnormal_heartbeat0.76022385
115MP0000647_abnormal_sebaceous_gland0.75415422
116MP0003631_nervous_system_phenotype0.75391668
117MP0005187_abnormal_penis_morphology0.73636151
118MP0003938_abnormal_ear_development0.71679628
119MP0003283_abnormal_digestive_organ0.70205443
120MP0004215_abnormal_myocardial_fiber0.67265216
121MP0003121_genomic_imprinting0.66660341
122MP0003634_abnormal_glial_cell0.65540431
123MP0004484_altered_response_of0.63425973
124MP0002876_abnormal_thyroid_physiology0.63379752
125MP0008872_abnormal_physiological_respon0.63031727
126MP0005535_abnormal_body_temperature0.62151759
127MP0001943_abnormal_respiration0.61390406
128MP0002751_abnormal_autonomic_nervous0.60617545
129MP0008874_decreased_physiological_sensi0.57972562
130MP0003119_abnormal_digestive_system0.57839378
131MP0005391_vision/eye_phenotype0.57638336
132MP0001664_abnormal_digestion0.57305828
133MP0001177_atelectasis0.57258600

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.03129086
2Septo-optic dysplasia (HP:0100842)6.38940315
3Focal seizures (HP:0007359)5.36678128
4Congenital stationary night blindness (HP:0007642)5.09403846
5Epileptic encephalopathy (HP:0200134)4.93798849
6Visual hallucinations (HP:0002367)4.70239069
7Myokymia (HP:0002411)4.49888528
8Atonic seizures (HP:0010819)4.43236852
9Absence seizures (HP:0002121)4.40453461
10Febrile seizures (HP:0002373)4.30841832
11Intestinal atresia (HP:0011100)4.29856483
12Oligodactyly (hands) (HP:0001180)4.12752487
13Hyperventilation (HP:0002883)4.07476541
14Broad-based gait (HP:0002136)4.00116531
15Dialeptic seizures (HP:0011146)3.97066881
16Progressive cerebellar ataxia (HP:0002073)3.78901165
17Absent septum pellucidum (HP:0001331)3.77389510
18Generalized tonic-clonic seizures (HP:0002069)3.60743532
19Amblyopia (HP:0000646)3.58498269
20Oligodactyly (HP:0012165)3.56720395
21Optic nerve hypoplasia (HP:0000609)3.35014540
22Humeroradial synostosis (HP:0003041)3.34805239
23Synostosis involving the elbow (HP:0003938)3.34805239
24Drooling (HP:0002307)3.34081876
25Excessive salivation (HP:0003781)3.34081876
26Abnormality of the septum pellucidum (HP:0007375)3.29490010
27Growth hormone deficiency (HP:0000824)3.24099434
28Supranuclear gaze palsy (HP:0000605)3.01803896
29Gastrointestinal atresia (HP:0002589)3.00079619
30Gait imbalance (HP:0002141)2.88898753
31Mutism (HP:0002300)2.85933175
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.85748844
33Truncal ataxia (HP:0002078)2.85492387
34Gaze-evoked nystagmus (HP:0000640)2.83168823
35Poor eye contact (HP:0000817)2.82193931
36Epileptiform EEG discharges (HP:0011182)2.78908645
37Abnormal hair whorl (HP:0010721)2.78262146
38Anophthalmia (HP:0000528)2.71475320
39Abnormality of macular pigmentation (HP:0008002)2.70399037
40Protruding tongue (HP:0010808)2.70348268
41Nephronophthisis (HP:0000090)2.69180611
42Cerebral inclusion bodies (HP:0100314)2.69032054
43Progressive inability to walk (HP:0002505)2.67954354
44Impaired vibration sensation in the lower limbs (HP:0002166)2.66482844
45Absent speech (HP:0001344)2.65710363
46EEG with generalized epileptiform discharges (HP:0011198)2.64835557
47Central scotoma (HP:0000603)2.60796767
48Bony spicule pigmentary retinopathy (HP:0007737)2.59472814
49Esophageal atresia (HP:0002032)2.58577141
50Inability to walk (HP:0002540)2.56437805
51Decreased central vision (HP:0007663)2.56061262
52Sleep apnea (HP:0010535)2.55891809
53Chronic hepatic failure (HP:0100626)2.52082720
54Dysdiadochokinesis (HP:0002075)2.50251598
55Polyphagia (HP:0002591)2.49920968
56Maternal diabetes (HP:0009800)2.48415773
57Insidious onset (HP:0003587)2.46238840
58Termporal pattern (HP:0011008)2.46238840
59Abnormal social behavior (HP:0012433)2.44798705
60Impaired social interactions (HP:0000735)2.44798705
61Hemiparesis (HP:0001269)2.42514702
62Congenital primary aphakia (HP:0007707)2.42341169
63Abnormal eating behavior (HP:0100738)2.40407515
64Aqueductal stenosis (HP:0002410)2.40267005
65Molar tooth sign on MRI (HP:0002419)2.39717355
66Abnormality of midbrain morphology (HP:0002418)2.39717355
67Rib fusion (HP:0000902)2.39668079
68Urinary bladder sphincter dysfunction (HP:0002839)2.39323436
69Amyotrophic lateral sclerosis (HP:0007354)2.38906745
70Split foot (HP:0001839)2.36598836
71Anxiety (HP:0000739)2.34978226
72Hypoplastic pelvis (HP:0008839)2.34278935
73Hypsarrhythmia (HP:0002521)2.34091533
74Medial flaring of the eyebrow (HP:0010747)2.32894945
75Abnormality of the corticospinal tract (HP:0002492)2.32026444
76Limb dystonia (HP:0002451)2.30702594
77Stereotypic behavior (HP:0000733)2.30144203
78Action tremor (HP:0002345)2.29850963
79Fetal akinesia sequence (HP:0001989)2.29172168
80Neurofibrillary tangles (HP:0002185)2.28160789
81True hermaphroditism (HP:0010459)2.27387777
82Depression (HP:0000716)2.26953243
83Dysmetria (HP:0001310)2.26060935
84Abnormality of salivation (HP:0100755)2.25823509
85Diplopia (HP:0000651)2.25324892
86Abnormality of binocular vision (HP:0011514)2.25324892
87Genetic anticipation (HP:0003743)2.24729084
88Pancreatic fibrosis (HP:0100732)2.22996261
89Hyperthyroidism (HP:0000836)2.22620612
90Choroideremia (HP:0001139)2.22402653
91Absent/shortened dynein arms (HP:0200106)2.19470921
92Dynein arm defect of respiratory motile cilia (HP:0012255)2.19470921
93Pancreatic cysts (HP:0001737)2.19217551
94Increased hepatocellular lipid droplets (HP:0006565)2.17733483
95Abnormal rod and cone electroretinograms (HP:0008323)2.17514933
96Inappropriate behavior (HP:0000719)2.16787586
97Exotropia (HP:0000577)2.14605218
98Abnormality of the renal medulla (HP:0100957)2.13662588
99Impaired smooth pursuit (HP:0007772)2.12445876
100Ankle clonus (HP:0011448)2.12203496
101Lipid accumulation in hepatocytes (HP:0006561)2.07900986
102Specific learning disability (HP:0001328)2.06764963
103Vitreoretinal degeneration (HP:0000655)2.06613548
104Nephrogenic diabetes insipidus (HP:0009806)2.06551163
105Holoprosencephaly (HP:0001360)2.05226755
106Hepatoblastoma (HP:0002884)2.05083480
107Spastic gait (HP:0002064)2.04628918
108Anencephaly (HP:0002323)2.03867959
109Abnormality of the lower motor neuron (HP:0002366)2.02944625
110Abnormal respiratory epithelium morphology (HP:0012253)2.02939268
111Abnormal respiratory motile cilium morphology (HP:0005938)2.02939268
112Hemivertebrae (HP:0002937)2.02818013
113Esotropia (HP:0000565)2.02393700
114Urinary urgency (HP:0000012)2.02329120
115Scotoma (HP:0000575)2.00245181
116Short 4th metacarpal (HP:0010044)1.99380570
117Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99380570
118Abnormal ciliary motility (HP:0012262)1.98972948
119Attenuation of retinal blood vessels (HP:0007843)1.97564464
120Severe visual impairment (HP:0001141)1.96836480
121Vaginal atresia (HP:0000148)1.95723502
122Lower limb amyotrophy (HP:0007210)1.95299417
123Generalized myoclonic seizures (HP:0002123)1.95107080
124Genital tract atresia (HP:0001827)1.94195610
125Megalencephaly (HP:0001355)1.93590330
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93098673
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92707045
128Degeneration of the lateral corticospinal tracts (HP:0002314)1.92707045
129Status epilepticus (HP:0002133)1.91593772
130Cystic liver disease (HP:0006706)1.90194852
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90058797
132Tubulointerstitial nephritis (HP:0001970)1.89899080
133Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.89565609
134Shawl scrotum (HP:0000049)1.89248260
135Abnormality of the labia minora (HP:0012880)1.89234346
136Type II lissencephaly (HP:0007260)1.89175138
137Volvulus (HP:0002580)1.88915488
138Abnormality of ocular smooth pursuit (HP:0000617)1.88086341
139Postaxial hand polydactyly (HP:0001162)1.88020426
140Abnormality of the aortic arch (HP:0012303)1.87454103
141Hypoventilation (HP:0002791)1.87072981
142Autism (HP:0000717)1.86908179
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.86437336
144Blue irides (HP:0000635)1.85636924
145Agitation (HP:0000713)1.85191817
146Hypoplasia of the brainstem (HP:0002365)1.84285341
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84285341
148Colon cancer (HP:0003003)1.81330754
149Dyschromatopsia (HP:0007641)1.80435305
150Pendular nystagmus (HP:0012043)1.80424106
151Medulloblastoma (HP:0002885)1.80226174
152Abnormal lung lobation (HP:0002101)1.78543821
153Partial duplication of thumb phalanx (HP:0009944)1.78350505
154Sclerocornea (HP:0000647)1.76918642
155Micropenis (HP:0000054)1.76823185
156Abnormality of the 4th metacarpal (HP:0010012)1.74984150
157Reticulocytopenia (HP:0001896)1.74275052
158Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73508241
159Tubulointerstitial abnormality (HP:0001969)1.71365394
160Delayed CNS myelination (HP:0002188)1.70235547
161Abnormal number of incisors (HP:0011064)1.68909831
162Renal Fanconi syndrome (HP:0001994)1.68227455
163Optic nerve coloboma (HP:0000588)1.68186902
164Renal hypoplasia (HP:0000089)1.68006270
165Ependymoma (HP:0002888)1.67501758
166Patellar aplasia (HP:0006443)1.66693612
167Preaxial hand polydactyly (HP:0001177)1.66306776
168Symphalangism affecting the phalanges of the hand (HP:0009773)1.65941758
169Agnosia (HP:0010524)1.65922631
170Poor coordination (HP:0002370)1.64946158
171Labial hypoplasia (HP:0000066)1.63852098
172Cerebellar dysplasia (HP:0007033)1.62485605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.59989885
2MARK14.39448564
3EPHA44.32680775
4NTRK33.76454787
5CASK3.30097642
6MAP3K93.21519122
7MAP3K43.18031404
8BMPR1B2.88798877
9MAP2K72.78961112
10MAP4K22.65171386
11PNCK2.63237464
12MAP3K122.51313793
13SIK22.42488919
14MINK12.34480804
15RIPK42.29755909
16NTRK22.27879397
17DAPK22.13795451
18MAPK132.01685593
19KSR11.91871471
20MAP2K41.91764812
21PLK21.82963411
22PAK61.79206534
23CDC71.78999370
24WEE11.74206263
25VRK11.70373607
26TNIK1.59239320
27DAPK11.47791497
28NME11.46079453
29CDK51.40374928
30CDK191.36630251
31GRK51.31836917
32UHMK11.31826675
33PRPF4B1.24133122
34KSR21.21785899
35DYRK1A1.20772810
36PRKCG1.19297187
37SRPK11.18774563
38CAMK2A1.17100320
39TRIM281.16893238
40VRK21.14032328
41NEK11.12108171
42MAPK151.11183092
43NTRK11.10760396
44NEK21.10741674
45WNK41.10619668
46PLK31.10552189
47FES1.09510966
48CCNB11.08731259
49BMPR21.08016927
50MKNK21.05968140
51TGFBR11.00252965
52CAMK2B0.98108189
53CAMKK10.96548714
54PHKG10.95235989
55PHKG20.95235989
56DYRK20.94840647
57LATS20.92222068
58EPHA30.91978624
59MKNK10.90680272
60CDK180.90120052
61DYRK30.87773543
62ACVR1B0.87724164
63CDK150.87208624
64FGR0.87188546
65CDK140.85810932
66MAP3K60.85049005
67PLK40.83062710
68CSNK1G20.82637219
69CAMK1G0.82043958
70TYRO30.79115245
71PIK3CA0.78077083
72EPHB20.77211552
73CDK11A0.76535690
74ERBB30.74654905
75PTK2B0.73909173
76OXSR10.73683762
77STK110.73187742
78PINK10.72027089
79MAP3K130.71756549
80TAF10.71258339
81GRK70.70494919
82BCR0.70186378
83STK380.70173568
84ERBB20.69300457
85ADRBK20.68087477
86ARAF0.66102831
87PRKCZ0.65907917
88CAMK10.65759807
89GRK10.64840544
90CDK80.63895851
91ADRBK10.62694893
92WNK30.62349124
93SGK10.62270960
94SGK2230.61941686
95SGK4940.61941686
96PKN10.60002693
97CSNK1G10.57064959
98MAPK120.54770014
99NUAK10.54165239
100MAPKAPK50.53884627
101CAMK1D0.53286840
102PLK10.53190641
103PAK30.51824967
104ZAK0.51429961
105CAMK2D0.50691566
106FGFR20.50530105
107BRSK10.48691685
108AKT30.47567805
109PRKCE0.47367191
110RET0.46610959
111SGK20.46008114
112CDK30.44101899
113ROCK20.42801917
114CSNK1G30.42009839
115CSNK1A1L0.41980249
116MARK20.41812884
117RAF10.41536153
118PRKD30.41249778
119MAP3K100.41153787
120GRK60.39084739
121MAPK100.38812932
122RPS6KA30.38532995
123PRKACB0.37540299
124CAMK40.36961120
125PRKCB0.36932092
126WNK10.36715744
127MARK30.36099073
128TAOK10.35838427
129PRKACA0.35572714
130CSNK1E0.34977824
131FYN0.34917762
132MAP3K20.34772630
133CDK90.34453191
134PDK10.32184357
135CAMKK20.31332452
136PRKG10.29836995
137MAP2K10.29766527
138BRAF0.28510108
139DAPK30.28290551
140CAMK2G0.27965419

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41319226
2Phototransduction_Homo sapiens_hsa047443.61664065
3Synaptic vesicle cycle_Homo sapiens_hsa047213.14877199
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97975253
5Ribosome_Homo sapiens_hsa030102.79107939
6Long-term potentiation_Homo sapiens_hsa047202.71453845
7GABAergic synapse_Homo sapiens_hsa047272.69055708
8Glutamatergic synapse_Homo sapiens_hsa047242.68791189
9Circadian entrainment_Homo sapiens_hsa047132.61675042
10Morphine addiction_Homo sapiens_hsa050322.61428279
11Olfactory transduction_Homo sapiens_hsa047402.53256362
12Amphetamine addiction_Homo sapiens_hsa050312.43882783
13Dopaminergic synapse_Homo sapiens_hsa047282.29544243
14Basal cell carcinoma_Homo sapiens_hsa052172.26952715
15Salivary secretion_Homo sapiens_hsa049702.10998286
16Protein export_Homo sapiens_hsa030602.05145797
17Taste transduction_Homo sapiens_hsa047422.00192489
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97548219
19Serotonergic synapse_Homo sapiens_hsa047261.93062083
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90325843
21Renin secretion_Homo sapiens_hsa049241.86874206
22Cholinergic synapse_Homo sapiens_hsa047251.84309806
23Long-term depression_Homo sapiens_hsa047301.82427062
24Insulin secretion_Homo sapiens_hsa049111.81927466
25RNA polymerase_Homo sapiens_hsa030201.70928296
26Gastric acid secretion_Homo sapiens_hsa049711.70153515
27Oxytocin signaling pathway_Homo sapiens_hsa049211.69907569
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65454722
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63542879
30Calcium signaling pathway_Homo sapiens_hsa040201.59252967
31Collecting duct acid secretion_Homo sapiens_hsa049661.58931945
32Axon guidance_Homo sapiens_hsa043601.57983527
33Fanconi anemia pathway_Homo sapiens_hsa034601.56297619
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54782148
35Cocaine addiction_Homo sapiens_hsa050301.50697249
36Hippo signaling pathway_Homo sapiens_hsa043901.45732409
37Steroid biosynthesis_Homo sapiens_hsa001001.42544698
38Cardiac muscle contraction_Homo sapiens_hsa042601.37215118
39Gap junction_Homo sapiens_hsa045401.36935259
40GnRH signaling pathway_Homo sapiens_hsa049121.36895504
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30325818
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26105798
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25443726
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24349786
45Basal transcription factors_Homo sapiens_hsa030221.20813651
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19234666
47Mismatch repair_Homo sapiens_hsa034301.17014623
48cAMP signaling pathway_Homo sapiens_hsa040241.14410791
49Melanogenesis_Homo sapiens_hsa049161.13032020
50Oxidative phosphorylation_Homo sapiens_hsa001901.12577107
51Alzheimers disease_Homo sapiens_hsa050101.12505255
52RNA degradation_Homo sapiens_hsa030181.10477407
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09541047
54Glioma_Homo sapiens_hsa052141.03813799
55ErbB signaling pathway_Homo sapiens_hsa040121.03392871
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02942458
57Estrogen signaling pathway_Homo sapiens_hsa049151.02877615
58Vibrio cholerae infection_Homo sapiens_hsa051101.01567300
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01098721
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97119895
61Type II diabetes mellitus_Homo sapiens_hsa049300.92484404
62Oocyte meiosis_Homo sapiens_hsa041140.92244278
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.84693929
64Nitrogen metabolism_Homo sapiens_hsa009100.82708866
65Propanoate metabolism_Homo sapiens_hsa006400.82151998
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82118243
67Parkinsons disease_Homo sapiens_hsa050120.79742346
68Folate biosynthesis_Homo sapiens_hsa007900.77870119
69Butanoate metabolism_Homo sapiens_hsa006500.74964423
70Homologous recombination_Homo sapiens_hsa034400.74727902
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74480209
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73974419
73TGF-beta signaling pathway_Homo sapiens_hsa043500.72715976
74Cell cycle_Homo sapiens_hsa041100.72182383
75Lysine degradation_Homo sapiens_hsa003100.71646973
76Ether lipid metabolism_Homo sapiens_hsa005650.71157899
77MAPK signaling pathway_Homo sapiens_hsa040100.71133921
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70539922
79Pancreatic secretion_Homo sapiens_hsa049720.70372256
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.69426185
81Huntingtons disease_Homo sapiens_hsa050160.68777256
82Choline metabolism in cancer_Homo sapiens_hsa052310.68595976
83Tryptophan metabolism_Homo sapiens_hsa003800.68320247
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68029535
85Wnt signaling pathway_Homo sapiens_hsa043100.67642226
86Dilated cardiomyopathy_Homo sapiens_hsa054140.66663209
87Notch signaling pathway_Homo sapiens_hsa043300.65792651
88Ovarian steroidogenesis_Homo sapiens_hsa049130.65510162
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65023156
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.64365726
91Pyruvate metabolism_Homo sapiens_hsa006200.64221074
92VEGF signaling pathway_Homo sapiens_hsa043700.63533459
93African trypanosomiasis_Homo sapiens_hsa051430.62967695
94Spliceosome_Homo sapiens_hsa030400.62165206
95Alcoholism_Homo sapiens_hsa050340.61652852
96mRNA surveillance pathway_Homo sapiens_hsa030150.60832888
97Thyroid hormone synthesis_Homo sapiens_hsa049180.58983172
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57711917
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57629068
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54729672
101Glucagon signaling pathway_Homo sapiens_hsa049220.53245181
102RNA transport_Homo sapiens_hsa030130.53076113
103Dorso-ventral axis formation_Homo sapiens_hsa043200.52604081
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52594815
105Ras signaling pathway_Homo sapiens_hsa040140.52252459
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52012573
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48475426
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.47811518
109Renal cell carcinoma_Homo sapiens_hsa052110.45953285
110Rap1 signaling pathway_Homo sapiens_hsa040150.45817921
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.43840545
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42321697
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40713848
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40704756
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40690717
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39889648
117Bile secretion_Homo sapiens_hsa049760.39365827
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39280801
119mTOR signaling pathway_Homo sapiens_hsa041500.39196355
120Circadian rhythm_Homo sapiens_hsa047100.39101459
121Retinol metabolism_Homo sapiens_hsa008300.38806076
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.38052101
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37781665
124Purine metabolism_Homo sapiens_hsa002300.37343170
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37055956
126Colorectal cancer_Homo sapiens_hsa052100.36395553
127Non-small cell lung cancer_Homo sapiens_hsa052230.35471798
128Linoleic acid metabolism_Homo sapiens_hsa005910.35044957
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34217498
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33603979
131Endometrial cancer_Homo sapiens_hsa052130.33523574
132Inositol phosphate metabolism_Homo sapiens_hsa005620.33300626
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32895605
134Prion diseases_Homo sapiens_hsa050200.32467947
135p53 signaling pathway_Homo sapiens_hsa041150.32137361
136Melanoma_Homo sapiens_hsa052180.31134330
137Hedgehog signaling pathway_Homo sapiens_hsa043400.28750220
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28006550
139Insulin signaling pathway_Homo sapiens_hsa049100.25394545
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23821972
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23041733
142Type I diabetes mellitus_Homo sapiens_hsa049400.22163016
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21879111
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21467507
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21078750

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