CCDC178

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.97568430
2acrosome reaction (GO:0007340)9.95203044
3piRNA metabolic process (GO:0034587)9.57124637
4motile cilium assembly (GO:0044458)9.12227749
5male meiosis (GO:0007140)8.86258680
6spermatid development (GO:0007286)8.84201017
7cilium movement (GO:0003341)8.72352541
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.58556452
9single fertilization (GO:0007338)7.84738183
10synaptonemal complex organization (GO:0070193)7.74159632
11synaptonemal complex assembly (GO:0007130)7.56299726
12regulation of cilium movement (GO:0003352)7.43790480
13sperm capacitation (GO:0048240)7.19593854
14fertilization (GO:0009566)6.54597675
15DNA methylation involved in gamete generation (GO:0043046)5.98959833
16spermatogenesis (GO:0007283)5.68342780
17male gamete generation (GO:0048232)5.66289333
18positive regulation of meiosis (GO:0045836)5.56842872
19oocyte development (GO:0048599)5.51466151
20ventricular system development (GO:0021591)5.48483933
21male meiosis I (GO:0007141)5.46191775
22negative regulation of inclusion body assembly (GO:0090084)5.43769424
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.41149471
24chromosome organization involved in meiosis (GO:0070192)5.36281869
25positive regulation of meiotic cell cycle (GO:0051446)5.24278841
26gamete generation (GO:0007276)5.23338078
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.21786012
28microtubule depolymerization (GO:0007019)5.19987899
29histone lysine demethylation (GO:0070076)5.15730776
30germ cell development (GO:0007281)5.06918409
31cell recognition (GO:0008037)4.99934045
32meiotic nuclear division (GO:0007126)4.99359283
33histone demethylation (GO:0016577)4.90658939
34calcium ion-dependent exocytosis (GO:0017156)4.90285526
35organic cation transport (GO:0015695)4.81179854
36monoubiquitinated protein deubiquitination (GO:0035520)4.75759686
37microtubule severing (GO:0051013)4.66686316
38regulation of retinoic acid receptor signaling pathway (GO:0048385)4.64365205
39spermatid nucleus differentiation (GO:0007289)4.61308389
40seminiferous tubule development (GO:0072520)4.51063197
41regulation of inclusion body assembly (GO:0090083)4.49462371
42protein dealkylation (GO:0008214)4.44804263
43protein demethylation (GO:0006482)4.44804263
44meiosis I (GO:0007127)4.41798473
45regulation of histone H3-K9 methylation (GO:0051570)4.34815458
46regulation of microtubule-based movement (GO:0060632)4.34669758
47meiotic cell cycle (GO:0051321)4.19347016
48protein localization to cilium (GO:0061512)4.12845329
49multicellular organismal reproductive process (GO:0048609)4.10840361
50DNA synthesis involved in DNA repair (GO:0000731)3.98626316
51regulation of acrosome reaction (GO:0060046)3.97714778
52positive regulation of histone H3-K4 methylation (GO:0051571)3.97131866
53genitalia morphogenesis (GO:0035112)3.86843003
54retinal cone cell development (GO:0046549)3.83795961
55regulation of female gonad development (GO:2000194)3.81967408
56regulation of meiosis (GO:0040020)3.81760465
57left/right pattern formation (GO:0060972)3.81631298
58intraciliary transport (GO:0042073)3.75356124
59glycerol ether metabolic process (GO:0006662)3.67355898
60regulation of centriole replication (GO:0046599)3.61600749
61protein polyglutamylation (GO:0018095)3.60251391
62regulation of DNA methylation (GO:0044030)3.58550848
63gene silencing by RNA (GO:0031047)3.58039881
64protein targeting to Golgi (GO:0000042)3.52447701
65reciprocal meiotic recombination (GO:0007131)3.50911378
66reciprocal DNA recombination (GO:0035825)3.50911378
67establishment of protein localization to Golgi (GO:0072600)3.47912289
68regulation of meiotic cell cycle (GO:0051445)3.47234435
69lactate metabolic process (GO:0006089)3.43958522
70chaperone-mediated protein complex assembly (GO:0051131)3.42251650
71centriole replication (GO:0007099)3.42136475
72microtubule-based movement (GO:0007018)3.40907952
73centriole assembly (GO:0098534)3.40568094
74ether metabolic process (GO:0018904)3.38780148
75multicellular organismal development (GO:0007275)3.32154049
76negative regulation of organelle assembly (GO:1902116)3.31051460
77synapsis (GO:0007129)3.30853352
78axoneme assembly (GO:0035082)3.24937411
79centrosome duplication (GO:0051298)3.22164288
80retrograde transport, vesicle recycling within Golgi (GO:0000301)3.19431619
81gonadal mesoderm development (GO:0007506)3.18452748
82cilium organization (GO:0044782)3.17824260
83protein K11-linked deubiquitination (GO:0035871)3.17352421
84N-terminal protein amino acid acetylation (GO:0006474)3.16655424
85meiotic cell cycle process (GO:1903046)3.15517116
86carnitine transport (GO:0015879)3.15474817
87amino-acid betaine transport (GO:0015838)3.15474817
88female gamete generation (GO:0007292)3.14522412
89regulation of exit from mitosis (GO:0007096)3.13462745
90carnitine transmembrane transport (GO:1902603)3.12260235
91alditol metabolic process (GO:0019400)3.11011509
92histone H3-K36 demethylation (GO:0070544)3.09139374
93DNA methylation (GO:0006306)3.06516800
94DNA alkylation (GO:0006305)3.06516800
95resolution of meiotic recombination intermediates (GO:0000712)3.05944103
96protein K48-linked deubiquitination (GO:0071108)3.05181206
97cilium assembly (GO:0042384)3.03947216
98negative regulation of histone methylation (GO:0031061)3.02746170
99polyol catabolic process (GO:0046174)3.00911192
100cellular component assembly involved in morphogenesis (GO:0010927)3.00421478
101regulation of spindle checkpoint (GO:0090231)2.95247753
102cilium morphogenesis (GO:0060271)2.93353239
103nucleoside diphosphate phosphorylation (GO:0006165)2.91785914
104positive regulation of gastrulation (GO:2000543)2.91119685
105regulation of female receptivity (GO:0045924)2.89385088
106protein localization to chromosome (GO:0034502)2.88829915
107glycerol metabolic process (GO:0006071)2.83921775
108regulation of meiosis I (GO:0060631)2.82543177
109nuclear pore complex assembly (GO:0051292)2.81725011
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80812724
111protein K6-linked ubiquitination (GO:0085020)2.78128861
112single strand break repair (GO:0000012)2.77887468
113sister chromatid cohesion (GO:0007062)2.76603315
114protein refolding (GO:0042026)2.74316427
115positive regulation of histone methylation (GO:0031062)2.71871658
116left/right axis specification (GO:0070986)2.71178597
117regulation of protein polyubiquitination (GO:1902914)2.71075217
118GTP biosynthetic process (GO:0006183)2.70256294
119microtubule polymerization or depolymerization (GO:0031109)2.68182373
120histone exchange (GO:0043486)2.67106098
121chromosome condensation (GO:0030261)2.66652151
122regulation of DNA endoreduplication (GO:0032875)2.62475022
123negative regulation of reproductive process (GO:2000242)2.62363160
124glycolytic process (GO:0006096)2.56232259
125DNA packaging (GO:0006323)2.55754377
126mitotic sister chromatid cohesion (GO:0007064)2.54982751
127nucleus organization (GO:0006997)2.53690550
128gene silencing (GO:0016458)2.51889349
129peptidyl-glutamic acid modification (GO:0018200)2.50044514
130single-organism membrane fusion (GO:0044801)2.46409835
131negative regulation of DNA repair (GO:0045738)2.45733460
132UTP biosynthetic process (GO:0006228)2.39535065
133cilium or flagellum-dependent cell motility (GO:0001539)15.2169293
134fusion of sperm to egg plasma membrane (GO:0007342)14.6146465
135acrosome assembly (GO:0001675)12.3648625
136multicellular organism reproduction (GO:0032504)12.2874479
137cell wall macromolecule metabolic process (GO:0044036)12.1715444
138cell wall macromolecule catabolic process (GO:0016998)12.1715444
139histone H3-K9 demethylation (GO:0033169)11.9395268
140sperm motility (GO:0030317)11.8948690
141sperm-egg recognition (GO:0035036)11.5632067
142plasma membrane fusion (GO:0045026)11.1315471
143axonemal dynein complex assembly (GO:0070286)10.5856280
144cell-cell recognition (GO:0009988)10.3498276
145binding of sperm to zona pellucida (GO:0007339)10.2694788
146reproduction (GO:0000003)10.0487297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.13921298
2EZH2_22144423_ChIP-Seq_EOC_Human4.51107428
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.03140245
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.59045664
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49335763
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.79598335
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.71696159
8GBX2_23144817_ChIP-Seq_PC3_Human2.65001387
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59467938
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48564138
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33379103
12TOP2B_26459242_ChIP-Seq_MCF-7_Human2.10352909
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.08312918
14IGF1R_20145208_ChIP-Seq_DFB_Human2.08159574
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07405124
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03493331
17ZNF274_21170338_ChIP-Seq_K562_Hela2.03340013
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01425061
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00628159
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3373779
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.98606543
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.97023198
23SMAD4_21799915_ChIP-Seq_A2780_Human1.94902048
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.93569051
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.93291110
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90469359
27STAT3_23295773_ChIP-Seq_U87_Human1.89379157
28P300_19829295_ChIP-Seq_ESCs_Human1.89348138
29AR_25329375_ChIP-Seq_VCAP_Human1.87883688
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84763001
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.84509436
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83428340
33FUS_26573619_Chip-Seq_HEK293_Human1.82161431
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76938442
35VDR_22108803_ChIP-Seq_LS180_Human1.76752526
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.76007570
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75147328
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.74219184
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70999528
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.70846125
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69099731
42KDM2B_26808549_Chip-Seq_REH_Human1.64447484
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62615883
44STAT1_17558387_ChIP-Seq_HELA_Human1.60918379
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.60023804
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58113656
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.58058771
48TAL1_26923725_Chip-Seq_HPCs_Mouse1.57728499
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56011373
50RUNX2_22187159_ChIP-Seq_PCA_Human1.55682013
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54778042
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54245675
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51175854
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49948453
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47961359
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.44705787
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43680937
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43100603
59CBP_20019798_ChIP-Seq_JUKART_Human1.42677491
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42677491
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.41999208
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40222792
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39640535
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39329956
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.37635883
66BCAT_22108803_ChIP-Seq_LS180_Human1.37353112
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36692713
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.36482003
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.36213135
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.36063568
71CBP_21632823_ChIP-Seq_H3396_Human1.35757564
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.34346323
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34182493
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.33805539
75SMAD4_21741376_ChIP-Seq_HESCs_Human1.33264304
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.30774122
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.29546837
78P53_22387025_ChIP-Seq_ESCs_Mouse1.29309159
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28377618
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27908676
81FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27764936
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27357256
83P300_18555785_Chip-Seq_ESCs_Mouse1.26431821
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.26292376
85TCF4_22108803_ChIP-Seq_LS180_Human1.25914538
86RNF2_27304074_Chip-Seq_NSC_Mouse1.25706271
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24591513
88SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24357239
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24118373
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23578405
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.23039865
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.22945072
93GATA3_21867929_ChIP-Seq_TH1_Mouse1.21635202
94REST_21632747_ChIP-Seq_MESCs_Mouse1.21056416
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21013735
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.20586723
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20100715
98NCOR_22424771_ChIP-Seq_293T_Human1.19213514
99ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18785442
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18696360
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18423530
102LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17221982
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16059782
104RXR_22108803_ChIP-Seq_LS180_Human1.14514892
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14341865
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14225141
107TP53_22573176_ChIP-Seq_HFKS_Human1.14127624
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.12488439
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12337097
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11010694
111TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10631369
112GF1_26923725_Chip-Seq_HPCs_Mouse1.09417867
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09298102
114SOX2_19829295_ChIP-Seq_ESCs_Human1.08728898
115NANOG_19829295_ChIP-Seq_ESCs_Human1.08728898
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08554418
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08025044
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.07951825
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07544674
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07544674
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06344326
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.06008340
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.05310208
124PU1_27457419_Chip-Seq_LIVER_Mouse1.04847880
125SMRT_27268052_Chip-Seq_Bcells_Human1.04645151
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04436975
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04142007
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03991553
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03746367
130IRF1_19129219_ChIP-ChIP_H3396_Human1.03452271
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03329625
132SMAD3_21741376_ChIP-Seq_ESCs_Human1.02947452
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02654542
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.01606481
135JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00976609
136JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00678884
137P53_21459846_ChIP-Seq_SAOS-2_Human1.00359956
138CDX2_22108803_ChIP-Seq_LS180_Human1.00053849
139ZFX_18555785_Chip-Seq_ESCs_Mouse1.00008373
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99815403
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.99673995
142SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99559392
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.99244582
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98956950
145SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98658499
146AR_21572438_ChIP-Seq_LNCaP_Human0.98628528
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98532089
148NMYC_18555785_Chip-Seq_ESCs_Mouse0.98368889
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97993242
150KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97993242
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97094142
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97000439
153TAF15_26573619_Chip-Seq_HEK293_Human0.95874076
154RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95583656
155GF1B_26923725_Chip-Seq_HPCs_Mouse0.93539234
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.93334410
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93095049
158TCF4_23295773_ChIP-Seq_U87_Human0.90416752
159ERG_20517297_ChIP-Seq_VCAP_Human0.90341310
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89524976
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.88688435
162SOX9_26525672_Chip-Seq_HEART_Mouse0.88634181
163FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86831457
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86015491
165ER_23166858_ChIP-Seq_MCF-7_Human0.85958017
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85885244
167STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85606132
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85051717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.01835465
2MP0001929_abnormal_gametogenesis5.59371913
3MP0008877_abnormal_DNA_methylation5.45443764
4MP0003718_maternal_effect4.02525095
5MP0002210_abnormal_sex_determination3.86856992
6MP0006292_abnormal_olfactory_placode3.84306115
7MP0002653_abnormal_ependyma_morphology3.83142317
8MP0002161_abnormal_fertility/fecundity3.27677449
9MP0001145_abnormal_male_reproductive3.25490615
10MP0000653_abnormal_sex_gland2.89093518
11MP0000678_abnormal_parathyroid_gland2.48447455
12MP0005623_abnormal_meninges_morphology2.37393456
13MP0003693_abnormal_embryo_hatching2.14131479
14MP0003136_yellow_coat_color2.13210632
15MP0005410_abnormal_fertilization15.1095626
16MP0006276_abnormal_autonomic_nervous1.84337121
17MP0002160_abnormal_reproductive_system1.83414389
18MP0008057_abnormal_DNA_replication1.64947837
19MP0008789_abnormal_olfactory_epithelium1.64514923
20MP0005670_abnormal_white_adipose1.59551669
21MP0003283_abnormal_digestive_organ1.58460525
22MP0002822_catalepsy1.52498184
23MP0005395_other_phenotype1.52431660
24MP0005394_taste/olfaction_phenotype1.52306827
25MP0005499_abnormal_olfactory_system1.52306827
26MP0008058_abnormal_DNA_repair1.51171865
27MP0009046_muscle_twitch1.50331745
28MP0002282_abnormal_trachea_morphology1.46165225
29MP0003119_abnormal_digestive_system1.42442574
30MP0000049_abnormal_middle_ear1.41741678
31MP0002102_abnormal_ear_morphology1.38472691
32MP0001666_abnormal_nutrient_absorption1.35407331
33MP0003646_muscle_fatigue1.35243336
34MP0005379_endocrine/exocrine_gland_phen1.32337206
35MP0001502_abnormal_circadian_rhythm1.29996324
36MP0000631_abnormal_neuroendocrine_gland1.22081680
37MP0005647_abnormal_sex_gland1.20289319
38MP0001664_abnormal_digestion1.20078136
39MP0003868_abnormal_feces_composition1.15120907
40MP0004270_analgesia1.14313737
41MP0004233_abnormal_muscle_weight1.13560995
42MP0010094_abnormal_chromosome_stability1.13350041
43MP0005646_abnormal_pituitary_gland1.12797620
44MP0001765_abnormal_ion_homeostasis1.12385907
45MP0001501_abnormal_sleep_pattern1.12242565
46MP0001486_abnormal_startle_reflex1.06364121
47MP0010030_abnormal_orbit_morphology1.04591999
48MP0005423_abnormal_somatic_nervous1.04023989
49MP0004859_abnormal_synaptic_plasticity1.02180567
50MP0001984_abnormal_olfaction1.01575731
51MP0001529_abnormal_vocalization1.00808498
52MP0005389_reproductive_system_phenotype0.97409202
53MP0008995_early_reproductive_senescence0.96490008
54MP0002735_abnormal_chemical_nociception0.96309065
55MP0002249_abnormal_larynx_morphology0.95984726
56MP0002272_abnormal_nervous_system0.95609096
57MP0003121_genomic_imprinting0.94956343
58MP0002127_abnormal_cardiovascular_syste0.92247588
59MP0002138_abnormal_hepatobiliary_system0.91345629
60MP0009745_abnormal_behavioral_response0.89953013
61MP0003183_abnormal_peptide_metabolism0.88060255
62MP0003936_abnormal_reproductive_system0.86739466
63MP0001485_abnormal_pinna_reflex0.85361306
64MP0002234_abnormal_pharynx_morphology0.84068665
65MP0009780_abnormal_chondrocyte_physiolo0.83747452
66MP0005360_urolithiasis0.83063627
67MP0008004_abnormal_stomach_pH0.82953464
68MP0001963_abnormal_hearing_physiology0.82831089
69MP0005220_abnormal_exocrine_pancreas0.82267526
70MP0002734_abnormal_mechanical_nocicepti0.82128409
71MP0009379_abnormal_foot_pigmentation0.78791810
72MP0003011_delayed_dark_adaptation0.77133541
73MP0010234_abnormal_vibrissa_follicle0.75266117
74MP0002067_abnormal_sensory_capabilities0.74467747
75MP0002108_abnormal_muscle_morphology0.73538549
76MP0000569_abnormal_digit_pigmentation0.73529584
77MP0003786_premature_aging0.73249629
78MP0001944_abnormal_pancreas_morphology0.72188046
79MP0008007_abnormal_cellular_replicative0.71220394
80MP0003195_calcinosis0.69896604
81MP0003950_abnormal_plasma_membrane0.69817169
82MP0010678_abnormal_skin_adnexa0.68414960
83MP0002928_abnormal_bile_duct0.68040618
84MP0003880_abnormal_central_pattern0.67412719
85MP0010368_abnormal_lymphatic_system0.66716628
86MP0002751_abnormal_autonomic_nervous0.66556874
87MP0002837_dystrophic_cardiac_calcinosis0.64120753
88MP0003699_abnormal_female_reproductive0.63388385
89MP0000026_abnormal_inner_ear0.61139811
90MP0000230_abnormal_systemic_arterial0.60821760
91MP0000383_abnormal_hair_follicle0.60588057
92MP0003959_abnormal_lean_body0.59904548
93MP0005375_adipose_tissue_phenotype0.59749615
94MP0004085_abnormal_heartbeat0.59465192
95MP0000470_abnormal_stomach_morphology0.59399542
96MP0001119_abnormal_female_reproductive0.59059763
97MP0005636_abnormal_mineral_homeostasis0.57878865
98MP0004036_abnormal_muscle_relaxation0.57226777
99MP0003111_abnormal_nucleus_morphology0.51897625
100MP0000358_abnormal_cell_content/0.50947470
101MP0010307_abnormal_tumor_latency0.48853561
102MP0005551_abnormal_eye_electrophysiolog0.48475360
103MP0005253_abnormal_eye_physiology0.47139392
104MP0000427_abnormal_hair_cycle0.46845112
105MP0001324_abnormal_eye_pigmentation0.45544051
106MP0004019_abnormal_vitamin_homeostasis0.45027317
107MP0004808_abnormal_hematopoietic_stem0.42828129
108MP0004134_abnormal_chest_morphology0.41816360
109MP0003115_abnormal_respiratory_system0.40822332
110MP0001545_abnormal_hematopoietic_system0.39849387
111MP0005397_hematopoietic_system_phenotyp0.39849387
112MP0002971_abnormal_brown_adipose0.37516178
113MP0004133_heterotaxia0.37180505
114MP0003890_abnormal_embryonic-extraembry0.36992855
115MP0004043_abnormal_pH_regulation0.36241459
116MP0001986_abnormal_taste_sensitivity0.35228776
117MP0006072_abnormal_retinal_apoptosis0.34694442
118MP0001293_anophthalmia0.32952088
119MP0005391_vision/eye_phenotype0.32763119
120MP0001730_embryonic_growth_arrest0.32661678
121MP0008961_abnormal_basal_metabolism0.32279568
122MP0009278_abnormal_bone_marrow0.31673678
123MP0003878_abnormal_ear_physiology0.31008396
124MP0005377_hearing/vestibular/ear_phenot0.31008396
125MP0003329_amyloid_beta_deposits0.28159933
126MP0003633_abnormal_nervous_system0.27743060
127MP0002084_abnormal_developmental_patter0.27669275
128MP0002269_muscular_atrophy0.27368219
129MP0000313_abnormal_cell_death0.26987050
130MP0006036_abnormal_mitochondrial_physio0.26749722
131MP0003861_abnormal_nervous_system0.23940857
132MP0002693_abnormal_pancreas_physiology0.23526885
133MP0000432_abnormal_head_morphology0.23526647
134MP0003077_abnormal_cell_cycle0.23508196
135MP0001764_abnormal_homeostasis0.23345432
136MP0003787_abnormal_imprinting0.22840972
137MP0005666_abnormal_adipose_tissue0.22639918
138MP0002152_abnormal_brain_morphology0.21770831
139MP0009115_abnormal_fat_cell0.21730884
140MP0000015_abnormal_ear_pigmentation0.21618055
141MP0001727_abnormal_embryo_implantation0.20762876
142MP0003631_nervous_system_phenotype0.20179784
143MP0003045_fibrosis0.19594670
144MP0003879_abnormal_hair_cell0.18670595
145MP0002139_abnormal_hepatobiliary_system0.18275782
146MP0002736_abnormal_nociception_after0.16641031
147MP0004811_abnormal_neuron_physiology0.16192602
148MP0000647_abnormal_sebaceous_gland0.15674992
149MP0001919_abnormal_reproductive_system0.15655519
150MP0002229_neurodegeneration0.15288116
151MP0001851_eye_inflammation0.15211370
152MP0002169_no_abnormal_phenotype0.14730244
153MP0002873_normal_phenotype0.14684058
154MP0001672_abnormal_embryogenesis/_devel0.14027870
155MP0005380_embryogenesis_phenotype0.14027870
156MP0005365_abnormal_bile_salt0.13813344
157MP0001697_abnormal_embryo_size0.12977200
158MP0002092_abnormal_eye_morphology0.12646487
159MP0005195_abnormal_posterior_eye0.12517153
160MP0003953_abnormal_hormone_level0.11973704
161MP0000001_mammalian_phenotype0.11372444
162MP0001968_abnormal_touch/_nociception0.10912690

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.66030149
2Abnormal respiratory epithelium morphology (HP:0012253)8.86641199
3Abnormal respiratory motile cilium morphology (HP:0005938)8.86641199
4Rhinitis (HP:0012384)8.04244760
5Abnormal ciliary motility (HP:0012262)8.03052342
6Chronic bronchitis (HP:0004469)7.50364570
7Nasal polyposis (HP:0100582)6.40952750
8Infertility (HP:0000789)6.07027350
9Abnormality of the nasal mucosa (HP:0000433)5.24318178
10Oligodactyly (hands) (HP:0001180)5.03042878
11Bronchiectasis (HP:0002110)4.68420699
12Bronchitis (HP:0012387)4.58361014
13Nephronophthisis (HP:0000090)4.40235553
14Short tibia (HP:0005736)4.03088536
15Aplasia/Hypoplasia of the tibia (HP:0005772)3.98337338
16Premature ovarian failure (HP:0008209)3.89045514
17Abnormality of abdominal situs (HP:0011620)3.73845947
18Abdominal situs inversus (HP:0003363)3.73845947
19Recurrent sinusitis (HP:0011108)3.64391388
20Congenital sensorineural hearing impairment (HP:0008527)3.45707099
21Abnormality of the renal medulla (HP:0100957)3.42022072
22Male infertility (HP:0003251)3.41726883
23Recurrent otitis media (HP:0000403)3.27982408
24Oligodactyly (HP:0012165)3.25563759
25Medial flaring of the eyebrow (HP:0010747)2.99791800
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.95809583
27Tubulointerstitial nephritis (HP:0001970)2.94269387
28Abnormal spermatogenesis (HP:0008669)2.91003916
29Abnormality of the labia minora (HP:0012880)2.85220869
30Hypophosphatemic rickets (HP:0004912)2.80514379
31Osteomalacia (HP:0002749)2.78943199
32Abnormality of the lower motor neuron (HP:0002366)2.78791594
33Volvulus (HP:0002580)2.76808684
34Facial hemangioma (HP:0000329)2.73466336
35Chronic hepatic failure (HP:0100626)2.71598016
36Abnormality of midbrain morphology (HP:0002418)2.71559260
37Molar tooth sign on MRI (HP:0002419)2.71559260
38Hyperphosphatemia (HP:0002905)2.66123246
39Recurrent bronchitis (HP:0002837)2.63691976
40Bony spicule pigmentary retinopathy (HP:0007737)2.63059488
41Anterior segment dysgenesis (HP:0007700)2.62436262
42Truncal obesity (HP:0001956)2.54988735
43Tubular atrophy (HP:0000092)2.47472742
44Gonadotropin excess (HP:0000837)2.44189269
45Tubulointerstitial abnormality (HP:0001969)2.37112429
46Attenuation of retinal blood vessels (HP:0007843)2.31026625
47Abnormality of lateral ventricle (HP:0030047)2.28917113
48Congenital malformation of the right heart (HP:0011723)2.28223310
49Double outlet right ventricle (HP:0001719)2.28223310
50Metaphyseal dysplasia (HP:0100255)2.27560816
51Amyotrophic lateral sclerosis (HP:0007354)2.27459600
52Azoospermia (HP:0000027)2.26356799
53Aplasia/Hypoplasia of the earlobes (HP:0009906)2.24913302
54Fibular hypoplasia (HP:0003038)2.23673143
55Optic nerve hypoplasia (HP:0000609)2.21252508
56Tetany (HP:0001281)2.16032245
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13868613
58Chromsome breakage (HP:0040012)2.13854835
59Postaxial foot polydactyly (HP:0001830)2.10297531
60Atonic seizures (HP:0010819)2.09728077
61Ectopic kidney (HP:0000086)2.08043401
62Abnormality of chromosome stability (HP:0003220)2.07847384
63Stage 5 chronic kidney disease (HP:0003774)2.06539737
64Abnormal auditory evoked potentials (HP:0006958)2.05615764
65Preaxial hand polydactyly (HP:0001177)2.02531416
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0262428
67Dynein arm defect of respiratory motile cilia (HP:0012255)12.6974222
68Absent/shortened dynein arms (HP:0200106)12.6974222
69Impulsivity (HP:0100710)1.99936336
70Congenital hepatic fibrosis (HP:0002612)1.99096808
71Degeneration of the lateral corticospinal tracts (HP:0002314)1.98248972
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98248972
73Congenital primary aphakia (HP:0007707)1.97574720
74Impaired proprioception (HP:0010831)1.96815498
75Microglossia (HP:0000171)1.96109791
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.95707446
77Gait imbalance (HP:0002141)1.95093307
78Severe visual impairment (HP:0001141)1.94008526
79Abnormality of the renal cortex (HP:0011035)1.93497888
80Maternal diabetes (HP:0009800)1.89504163
81Menstrual irregularities (HP:0000858)1.87480330
82Facial cleft (HP:0002006)1.86237848
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84612314
84Chronic sinusitis (HP:0011109)1.84539611
85Absent frontal sinuses (HP:0002688)1.84211137
86Shoulder girdle muscle weakness (HP:0003547)1.83985323
87Abnormality of calcium-phosphate metabolism (HP:0100530)1.83512501
88Insulin-resistant diabetes mellitus (HP:0000831)1.83216532
89Pancreatic cysts (HP:0001737)1.82412650
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81384157
91Abnormal pancreas size (HP:0012094)1.81364822
92Abnormality of the corticospinal tract (HP:0002492)1.81021212
93Abnormality of the ileum (HP:0001549)1.79773175
94Fair hair (HP:0002286)1.79770263
95Occipital encephalocele (HP:0002085)1.79701601
96Tubulointerstitial fibrosis (HP:0005576)1.78389994
97Meckel diverticulum (HP:0002245)1.77672462
98Renal dysplasia (HP:0000110)1.77204944
99Bicornuate uterus (HP:0000813)1.76456362
100Cone-rod dystrophy (HP:0000548)1.76393645
101Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73380940
102Abnormality of permanent molar morphology (HP:0011071)1.73134377
103Abnormality of the dental root (HP:0006486)1.73134377
104Taurodontia (HP:0000679)1.73134377
105J-shaped sella turcica (HP:0002680)1.72553237
106Enlarged penis (HP:0000040)1.71966192
107Supernumerary spleens (HP:0009799)1.71705490
108Wrist flexion contracture (HP:0001239)1.71064464
109Postaxial hand polydactyly (HP:0001162)1.70980177
110Pancreatic fibrosis (HP:0100732)1.70245718
111Amelogenesis imperfecta (HP:0000705)1.70200558
112Short ribs (HP:0000773)1.69951272
113Hypoglycemic coma (HP:0001325)1.68708284
114Sensory axonal neuropathy (HP:0003390)1.67051016
115Nephrogenic diabetes insipidus (HP:0009806)1.67008607
116Small intestinal stenosis (HP:0012848)1.66670279
117Duodenal stenosis (HP:0100867)1.66670279
118Oculomotor apraxia (HP:0000657)1.66186198
119Abnormal drinking behavior (HP:0030082)1.66001329
120Polydipsia (HP:0001959)1.66001329
121Capillary hemangiomas (HP:0005306)1.65526638
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.64125405
123Gaze-evoked nystagmus (HP:0000640)1.63379120
124Abnormality of renal resorption (HP:0011038)1.63144560
125Abnormality of molar morphology (HP:0011070)1.63105733
126Abnormality of molar (HP:0011077)1.63105733
127Abnormality of the dental pulp (HP:0006479)1.62809356
128Spontaneous abortion (HP:0005268)1.62434035
129Median cleft lip (HP:0000161)1.58605058
130Abnormality of renal excretion (HP:0011036)1.58202174
131Abnormality of dentin (HP:0010299)1.55214942
132Upper motor neuron abnormality (HP:0002127)1.54471578
133Cystic liver disease (HP:0006706)1.51449603
134Poor coordination (HP:0002370)1.47545893
135Spastic tetraparesis (HP:0001285)1.47475225
136Heterotopia (HP:0002282)1.47262278
137Genital tract atresia (HP:0001827)1.45981643
138Abnormality of the anterior horn cell (HP:0006802)1.45821718
139Degeneration of anterior horn cells (HP:0002398)1.45821718
140Aplasia/Hypoplasia of the lens (HP:0008063)1.44573887
141Aplasia/Hypoplasia of the fibula (HP:0006492)1.43860147
142Breast carcinoma (HP:0003002)1.43268388
143Vaginal atresia (HP:0000148)1.42191816
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41154182
145Absent epiphyses (HP:0010577)1.41154182
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.39889513
147Abnormality of ocular smooth pursuit (HP:0000617)1.39887563
148Short thorax (HP:0010306)1.37829816
149Bell-shaped thorax (HP:0001591)1.36596188
150Tongue fasciculations (HP:0001308)1.35659306
151Abnormal biliary tract physiology (HP:0012439)1.33692201
152Bile duct proliferation (HP:0001408)1.33692201
153True hermaphroditism (HP:0010459)1.32470270
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.30571099
155Dyschromatopsia (HP:0007641)1.30413175
156Abnormality of saccadic eye movements (HP:0000570)1.29490645
157Decreased central vision (HP:0007663)1.29354592
158Short femoral neck (HP:0100864)1.29010637
159Nephropathy (HP:0000112)1.27905007
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.27467036
161Abnormal gallbladder physiology (HP:0012438)1.27460134
162Cholecystitis (HP:0001082)1.27460134
163Deformed sella turcica (HP:0002681)1.27447705
16411 pairs of ribs (HP:0000878)1.25000629
165Muscle fibrillation (HP:0010546)1.21673023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.43523172
2PDK39.43523172
3PDK26.11783098
4STK164.30155065
5TESK13.70230210
6PRKD33.33280077
7TNIK3.21151928
8MAP3K93.03156372
9TAOK32.82556877
10ARAF2.82323223
11ICK2.57225951
12CDK192.42561065
13WNK42.41394810
14MET2.38103266
15STK392.31749871
16PNCK2.30449811
17PTK2B2.30101289
18PLK21.78876990
19TRIM281.75775094
20NEK21.68614495
21OXSR11.57804057
22MAP3K131.45711608
23ZAK1.39796983
24NLK1.39281105
25FRK1.36905088
26MOS1.24083098
27STK381.21305462
28MAPK131.14033627
29TIE11.11086668
30LATS21.03761305
31VRK11.02253908
32INSRR1.01983910
33MAP4K21.01320168
34STK241.00979602
35CDK91.00106810
36WNK10.95529469
37TLK10.95125258
38PDK10.90796259
39CCNB10.86848338
40STK30.86840271
41MAPK150.85714712
42PASK0.85076585
43CDC70.84244535
44PLK40.83617167
45TYRO30.83337407
46CDK70.83208855
47DDR20.80198670
48IRAK10.78980196
49WEE10.77494451
50TTK0.77045856
51DYRK1B0.76706230
52LMTK20.74459148
53TEC0.74343906
54EPHA40.72285987
55CAMK1G0.70438289
56SRPK10.67776811
57CHEK20.66390065
58RAF10.63892542
59DYRK30.62815705
60CAMK10.60063734
61AURKB0.58256627
62CDK50.56732660
63STK38L0.56009709
64PRKCI0.55012390
65BMPR1B0.54541589
66MAPKAPK30.53986014
67MUSK0.53897947
68MELK0.51683470
69TGFBR10.51344271
70CHEK10.50719042
71BRD40.50457157
72CSNK1E0.49080954
73CSNK1G10.46349733
74ADRBK20.45020133
75ROCK10.44683306
76PINK10.44517116
77BRSK20.43378496
78CDK120.42614303
79ATR0.42504934
80TAOK10.41056627
81RET0.39861772
82ATM0.37874735
83MAP3K40.37778237
84MAP2K70.37764395
85SGK10.36746825
86MAPK10.36571530
87PIK3CG0.35317856
88TRPM70.34513033
89NTRK30.34044281
90TESK20.33682103
91EEF2K0.33328101
92MAP2K60.32795151
93PRKAA20.32666734
94MAPKAPK50.32611311
95PDPK10.31162146
96PLK10.30791884
97TNK20.30355768
98CAMKK10.30276564
99KSR20.29018590
100NTRK20.28692323
101NUAK10.28296660
102BRAF0.27405604
103NEK90.26913792
104PRKCE0.26090909
105MARK10.25804163
106MARK20.22396047
107PRKAA10.22106858
108PAK10.22105995
109MTOR0.21897062
110RPS6KB10.21478494
111IRAK20.20650336
112PRKCG0.19960115
113MARK30.19368074
114WNK30.18179393
115NEK60.17579386
116BRSK10.13797315
117RIPK40.10452602
118LATS10.09750021
119CSNK1D0.09003241
120PAK20.07472308
121PAK60.07222252
122ACVR1B0.07092546
123PRKG10.06925426
124OBSCN0.06529095
125CDK10.06393206
126PRKCQ0.06120774
127CSNK2A10.05899025
128PRKACG0.05701500
129GSK3B0.05640626
130CDK30.05440828
131CDK20.05023133
132PRKACB0.04464333
133PDGFRB0.03691391
134PRKDC0.03550531
135STK110.03082688
136PRKG20.02837883
137CSNK2A20.02837564
138RIPK10.02155627
139MAPK100.01856157
140CAMK2A0.01710509
141RPS6KA10.01646736
142CAMK1D0.01280349
143ZAP700.01109352
144PRKCZ0.00999070
145PKN10.00725936
146CDK18-0.0298334
147PRKACA-0.0287377
148PRKCB-0.0251697
149AURKA-0.0232597
150SCYL2-0.0231211
151RPS6KA3-0.0207376
152YES1-0.0165120
153STK10-0.0145895
154EGFR-0.0139958
155CDK15-0.0054167
156MAPK8-0.0001106

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.19914182
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.39217888
3Pyruvate metabolism_Homo sapiens_hsa006204.35979805
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.05044062
5Propanoate metabolism_Homo sapiens_hsa006403.49104855
6Basal transcription factors_Homo sapiens_hsa030223.03574657
7Glucagon signaling pathway_Homo sapiens_hsa049222.96036016
8Fatty acid biosynthesis_Homo sapiens_hsa000612.87703089
9Pentose phosphate pathway_Homo sapiens_hsa000302.70321436
10Mismatch repair_Homo sapiens_hsa034302.57850226
11Fanconi anemia pathway_Homo sapiens_hsa034602.45576761
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45485095
13Olfactory transduction_Homo sapiens_hsa047402.41612527
14Selenocompound metabolism_Homo sapiens_hsa004502.39482035
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36463385
16Dorso-ventral axis formation_Homo sapiens_hsa043202.29832584
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.29579256
18Linoleic acid metabolism_Homo sapiens_hsa005912.28688677
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.17444474
20Oocyte meiosis_Homo sapiens_hsa041142.13750024
21Huntingtons disease_Homo sapiens_hsa050161.96830956
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92470122
23Glycerolipid metabolism_Homo sapiens_hsa005611.83132911
24Circadian rhythm_Homo sapiens_hsa047101.82328055
25Phototransduction_Homo sapiens_hsa047441.77223440
26Butanoate metabolism_Homo sapiens_hsa006501.71077507
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59652821
28PPAR signaling pathway_Homo sapiens_hsa033201.52941815
29Amphetamine addiction_Homo sapiens_hsa050311.52154753
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.45185954
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40461787
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36316823
33Non-homologous end-joining_Homo sapiens_hsa034501.35455482
34Nicotine addiction_Homo sapiens_hsa050331.34249703
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33076463
36Sulfur metabolism_Homo sapiens_hsa009201.31462043
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.29325078
38Regulation of autophagy_Homo sapiens_hsa041401.28809315
39Carbon metabolism_Homo sapiens_hsa012001.28665788
40Renin secretion_Homo sapiens_hsa049241.27031719
41RNA transport_Homo sapiens_hsa030131.24084757
42mRNA surveillance pathway_Homo sapiens_hsa030151.21843571
43Folate biosynthesis_Homo sapiens_hsa007901.17938795
44Purine metabolism_Homo sapiens_hsa002301.13332823
45Tryptophan metabolism_Homo sapiens_hsa003801.12856189
46Fructose and mannose metabolism_Homo sapiens_hsa000511.12801065
47Cardiac muscle contraction_Homo sapiens_hsa042601.11066662
48Fatty acid elongation_Homo sapiens_hsa000621.09243508
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.08171612
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03746469
51Ether lipid metabolism_Homo sapiens_hsa005651.03427807
52Mineral absorption_Homo sapiens_hsa049781.00503986
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97209343
54Antigen processing and presentation_Homo sapiens_hsa046120.96575514
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96485045
56Nucleotide excision repair_Homo sapiens_hsa034200.96049468
57Morphine addiction_Homo sapiens_hsa050320.94185097
58Phenylalanine metabolism_Homo sapiens_hsa003600.91153754
59N-Glycan biosynthesis_Homo sapiens_hsa005100.87849236
60Serotonergic synapse_Homo sapiens_hsa047260.87566858
61Biosynthesis of amino acids_Homo sapiens_hsa012300.87244951
62GABAergic synapse_Homo sapiens_hsa047270.86316514
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84685715
64ABC transporters_Homo sapiens_hsa020100.82796416
65Long-term potentiation_Homo sapiens_hsa047200.82282529
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82214176
67Tyrosine metabolism_Homo sapiens_hsa003500.82099336
68Fat digestion and absorption_Homo sapiens_hsa049750.81768791
69Fatty acid degradation_Homo sapiens_hsa000710.79341274
70DNA replication_Homo sapiens_hsa030300.78906796
71Caffeine metabolism_Homo sapiens_hsa002320.77680565
72Base excision repair_Homo sapiens_hsa034100.76832315
73Fatty acid metabolism_Homo sapiens_hsa012120.76714837
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74131846
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74002541
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73410713
77Insulin secretion_Homo sapiens_hsa049110.71859148
78Type II diabetes mellitus_Homo sapiens_hsa049300.70528493
79Estrogen signaling pathway_Homo sapiens_hsa049150.69884006
80Renin-angiotensin system_Homo sapiens_hsa046140.69519310
81Taste transduction_Homo sapiens_hsa047420.68014053
82TGF-beta signaling pathway_Homo sapiens_hsa043500.66443341
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65522454
84Lysine degradation_Homo sapiens_hsa003100.64541788
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62218920
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61902757
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61343601
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61201025
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61188696
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59633016
91Calcium signaling pathway_Homo sapiens_hsa040200.59002967
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58661892
93beta-Alanine metabolism_Homo sapiens_hsa004100.58474656
94Inositol phosphate metabolism_Homo sapiens_hsa005620.57829004
95Collecting duct acid secretion_Homo sapiens_hsa049660.55223782
96Glutathione metabolism_Homo sapiens_hsa004800.53272773
97Gap junction_Homo sapiens_hsa045400.53043923
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52564304
99Homologous recombination_Homo sapiens_hsa034400.51834646
100Dopaminergic synapse_Homo sapiens_hsa047280.49695841
101Chemical carcinogenesis_Homo sapiens_hsa052040.49102211
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49093570
103Gastric acid secretion_Homo sapiens_hsa049710.48470286
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48397381
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47098472
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.46991039
107Thyroid hormone synthesis_Homo sapiens_hsa049180.45269474
108VEGF signaling pathway_Homo sapiens_hsa043700.44256285
109Alcoholism_Homo sapiens_hsa050340.42855251
110Arachidonic acid metabolism_Homo sapiens_hsa005900.42164382
111Tight junction_Homo sapiens_hsa045300.42046595
112RNA degradation_Homo sapiens_hsa030180.41612526
113Adherens junction_Homo sapiens_hsa045200.40771011
114Hippo signaling pathway_Homo sapiens_hsa043900.40622065
115Cholinergic synapse_Homo sapiens_hsa047250.40236006
116Metabolic pathways_Homo sapiens_hsa011000.40146794
117AMPK signaling pathway_Homo sapiens_hsa041520.39494744
118Cell cycle_Homo sapiens_hsa041100.39375153
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.37860796
120Synaptic vesicle cycle_Homo sapiens_hsa047210.37719417
121Arginine and proline metabolism_Homo sapiens_hsa003300.35385978
122Endocytosis_Homo sapiens_hsa041440.35257943
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34038859
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33849486
125Bile secretion_Homo sapiens_hsa049760.33617364
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.30199806
127Systemic lupus erythematosus_Homo sapiens_hsa053220.29719977
128Circadian entrainment_Homo sapiens_hsa047130.28178979
129cAMP signaling pathway_Homo sapiens_hsa040240.27885216
130Pyrimidine metabolism_Homo sapiens_hsa002400.27601454
131Hedgehog signaling pathway_Homo sapiens_hsa043400.25946526
132Legionellosis_Homo sapiens_hsa051340.25731978
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24498584
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.23517164
135Pancreatic secretion_Homo sapiens_hsa049720.22277408
136Protein digestion and absorption_Homo sapiens_hsa049740.21159118
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19609992
138B cell receptor signaling pathway_Homo sapiens_hsa046620.16637471
139Cocaine addiction_Homo sapiens_hsa050300.16513930
140Wnt signaling pathway_Homo sapiens_hsa043100.16080786
141Retinol metabolism_Homo sapiens_hsa008300.15226618
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.15007467
143Viral carcinogenesis_Homo sapiens_hsa052030.14954960
144Glutamatergic synapse_Homo sapiens_hsa047240.14333113
145Salivary secretion_Homo sapiens_hsa049700.12525394
146Ovarian steroidogenesis_Homo sapiens_hsa049130.12470630
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.11769134

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