CCDC179

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.41189341
2regulation of phosphoprotein phosphatase activity (GO:0043666)8.97578577
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)8.31679389
4multicellular organism reproduction (GO:0032504)7.99283620
5binding of sperm to zona pellucida (GO:0007339)7.93967935
6male meiosis (GO:0007140)7.64030133
7fusion of sperm to egg plasma membrane (GO:0007342)7.61838939
8motile cilium assembly (GO:0044458)7.56127649
9sperm-egg recognition (GO:0035036)7.16303728
10axonemal dynein complex assembly (GO:0070286)7.06825791
11positive regulation of catecholamine secretion (GO:0033605)6.91324881
12reproduction (GO:0000003)6.39965560
13cell-cell recognition (GO:0009988)6.15355060
14calcium ion-dependent exocytosis (GO:0017156)5.98924913
15plasma membrane fusion (GO:0045026)5.94734539
16protein-DNA complex disassembly (GO:0032986)5.92086681
17nucleosome disassembly (GO:0006337)5.92086681
18cilium or flagellum-dependent cell motility (GO:0001539)5.88746883
19epithelial cilium movement (GO:0003351)5.70223685
20single fertilization (GO:0007338)5.69025136
21organic cation transport (GO:0015695)5.57218429
22germ cell development (GO:0007281)5.48536030
23phosphatidylethanolamine biosynthetic process (GO:0006646)5.41824164
24potassium ion export (GO:0071435)5.41767480
25polyamine biosynthetic process (GO:0006596)5.27050330
26negative regulation of inclusion body assembly (GO:0090084)5.16779744
27protein targeting to Golgi (GO:0000042)5.04378194
28sperm capacitation (GO:0048240)5.02297991
29spermatid nucleus differentiation (GO:0007289)5.01496883
30coenzyme catabolic process (GO:0009109)4.97816648
31phosphatidylethanolamine metabolic process (GO:0046337)4.97176360
32microtubule depolymerization (GO:0007019)4.91173856
33regulation of oxidative stress-induced neuron death (GO:1903203)4.89931499
34establishment of protein localization to Golgi (GO:0072600)4.80084800
35cilium movement (GO:0003341)4.76456450
36spermatogenesis (GO:0007283)4.73890648
37ventricular system development (GO:0021591)4.73573760
38male gamete generation (GO:0048232)4.72740173
39male sex determination (GO:0030238)4.71195465
40chromosome condensation (GO:0030261)4.65587797
41relaxation of smooth muscle (GO:0044557)4.64044137
42retrograde transport, vesicle recycling within Golgi (GO:0000301)4.60529570
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.56435887
44response to acidic pH (GO:0010447)4.52257865
45protein polyglutamylation (GO:0018095)4.48313638
46Leydig cell differentiation (GO:0033327)4.44042134
47synapsis (GO:0007129)4.42571109
48rRNA methylation (GO:0031167)4.42243922
49regulation of oxidative phosphorylation (GO:0002082)4.41615138
50DNA packaging (GO:0006323)4.40466133
51activation of protein kinase B activity (GO:0032148)4.37778273
52gamete generation (GO:0007276)4.36940620
53fertilization (GO:0009566)4.34264626
54centriole assembly (GO:0098534)4.15751216
55positive regulation of glycolytic process (GO:0045821)4.11039871
56cGMP-mediated signaling (GO:0019934)4.09598726
57regulation of autophagic vacuole assembly (GO:2000785)3.94209918
58glutamine family amino acid catabolic process (GO:0009065)3.93177318
59single strand break repair (GO:0000012)3.92904372
60microtubule polymerization or depolymerization (GO:0031109)3.80787101
61acrosome assembly (GO:0001675)3.77921991
62mitochondrion degradation (GO:0000422)3.69534804
63protein localization to Golgi apparatus (GO:0034067)3.68023262
64cellular biogenic amine biosynthetic process (GO:0042401)3.64680765
65regulation of dopamine secretion (GO:0014059)3.64112766
66detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.62528210
67amine biosynthetic process (GO:0009309)3.59519506
68negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.57648589
69histone exchange (GO:0043486)3.57571936
70rRNA modification (GO:0000154)3.55357755
71cellular ketone body metabolic process (GO:0046950)3.54919009
72regulation of inclusion body assembly (GO:0090083)3.54599712
73androgen biosynthetic process (GO:0006702)3.53577198
74oogenesis (GO:0048477)3.53117799
75multicellular organismal reproductive process (GO:0048609)3.52530033
76protein polymerization (GO:0051258)3.47638300
77tongue development (GO:0043586)3.45698717
78regulation of phosphatase activity (GO:0010921)3.45336976
79response to pheromone (GO:0019236)3.38490233
80regulation of synaptic transmission, dopaminergic (GO:0032225)3.35481261
81cellular response to pH (GO:0071467)3.33228185
82glycogen metabolic process (GO:0005977)3.32219825
83glucan metabolic process (GO:0044042)3.29189563
84cellular glucan metabolic process (GO:0006073)3.29189563
85microtubule severing (GO:0051013)3.29102733
86positive regulation of Rab GTPase activity (GO:0032851)3.28638821
87regulation of Rab GTPase activity (GO:0032313)3.28638821
88piRNA metabolic process (GO:0034587)3.27450871
89regulation of vacuole organization (GO:0044088)3.24399123
90negative regulation of response to reactive oxygen species (GO:1901032)3.24383984
91histone H3-K9 demethylation (GO:0033169)3.23004513
92regulation of ARF GTPase activity (GO:0032312)3.22570750
93chromosome organization involved in meiosis (GO:0070192)3.21688496
94dicarboxylic acid biosynthetic process (GO:0043650)3.21389305
95epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18702032
96meiotic nuclear division (GO:0007126)3.16463286
97regulation of hydrogen peroxide-induced cell death (GO:1903205)3.15949058
98regulation of cilium movement (GO:0003352)3.14958775
99acrosome reaction (GO:0007340)11.3916471
100sperm motility (GO:0030317)10.9711750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.25338472
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.41440850
3IGF1R_20145208_ChIP-Seq_DFB_Human3.26959921
4VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.02839036
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.59581265
6FUS_26573619_Chip-Seq_HEK293_Human2.58973378
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.53431486
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.51826146
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38157249
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35851079
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33426471
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.33426471
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26585937
14ARNT_22903824_ChIP-Seq_MCF-7_Human2.21863558
15EZH2_22144423_ChIP-Seq_EOC_Human2.13908723
16CBP_20019798_ChIP-Seq_JUKART_Human2.01817731
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.01817731
18ER_23166858_ChIP-Seq_MCF-7_Human1.96667676
19NANOG_20526341_ChIP-Seq_ESCs_Human1.88107639
20AHR_22903824_ChIP-Seq_MCF-7_Human1.85661337
21GBX2_23144817_ChIP-Seq_PC3_Human1.85244898
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84371679
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73694525
24RAC3_21632823_ChIP-Seq_H3396_Human1.72022195
25ERA_21632823_ChIP-Seq_H3396_Human1.67738662
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64063187
27AR_21572438_ChIP-Seq_LNCaP_Human1.63858586
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.61872364
29CTCF_27219007_Chip-Seq_Bcells_Human1.55066091
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.54963498
31P300_19829295_ChIP-Seq_ESCs_Human1.54787845
32KLF5_20875108_ChIP-Seq_MESCs_Mouse1.50679539
33MYC_19829295_ChIP-Seq_ESCs_Human1.50275340
34TP53_18474530_ChIP-ChIP_U2OS_Human1.49259790
35TBL1_22424771_ChIP-Seq_293T_Human1.48305539
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44245363
37OCT1_27270436_Chip-Seq_PROSTATE_Human1.41376352
38OCT4_20526341_ChIP-Seq_ESCs_Human1.40356013
39EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.36734280
40RUNX2_22187159_ChIP-Seq_PCA_Human1.35522751
41SMAD4_21799915_ChIP-Seq_A2780_Human1.34989258
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.34465036
43AR_25329375_ChIP-Seq_VCAP_Human1.30447659
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30377207
45ERG_20517297_ChIP-Seq_VCAP_Human1.30211884
46SMC4_20622854_ChIP-Seq_HELA_Human1.29147289
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27383900
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25869864
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25465067
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20853414
51VDR_22108803_ChIP-Seq_LS180_Human1.18588391
52CTCF_20526341_ChIP-Seq_ESCs_Human1.15743896
53BCAT_22108803_ChIP-Seq_LS180_Human1.14318519
54NANOG_19829295_ChIP-Seq_ESCs_Human1.13688536
55SOX2_19829295_ChIP-Seq_ESCs_Human1.13688536
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13311099
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12874534
58STAT3_23295773_ChIP-Seq_U87_Human1.12843247
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.12316821
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11291083
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.09878052
62NFYB_21822215_ChIP-Seq_K562_Human1.09753310
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07761472
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06849675
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.06001370
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04476999
67P300_27268052_Chip-Seq_Bcells_Human1.03910641
68PHF8_20622853_ChIP-Seq_HELA_Human1.03870610
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03713991
70HOXB7_26014856_ChIP-Seq_BT474_Human1.03464906
71ZNF274_21170338_ChIP-Seq_K562_Hela1.02956990
72CJUN_26792858_Chip-Seq_BT549_Human1.01787947
73RBPJ_21746931_ChIP-Seq_IB4_Human1.01599813
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97571674
75ETV1_20927104_ChIP-Seq_GIST48_Human0.96955775
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96462224
77PHF8_20622854_ChIP-Seq_HELA_Human0.96103567
78TP63_22573176_ChIP-Seq_HFKS_Human0.93624578
79SMAD3_21741376_ChIP-Seq_ESCs_Human0.93179859
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92505991
81ELF1_20517297_ChIP-Seq_JURKAT_Human0.92063347
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92019337
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.91626368
84RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91570198
85TP63_23658742_ChIP-Seq_EP156T_Human0.90383913
86NFYA_21822215_ChIP-Seq_K562_Human0.90196177
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90154016
88E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89876943
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.88501634
90RXR_22108803_ChIP-Seq_LS180_Human0.88096851
91SPI1_20517297_ChIP-Seq_HL60_Human0.85996790
92STAT1_17558387_ChIP-Seq_HELA_Human0.85516251
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85436281
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84689231
95GF1_26923725_Chip-Seq_HPCs_Mouse0.83929043
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83400977
97E2F1_20622854_ChIP-Seq_HELA_Human0.82406000
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.82315298
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82301691
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82258094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.19932434
2MP0003315_abnormal_perineum_morphology5.09618952
3MP0003698_abnormal_male_reproductive4.00425026
4MP0001929_abnormal_gametogenesis3.51701579
5MP0002160_abnormal_reproductive_system2.71014027
6MP0002132_abnormal_respiratory_system2.70181683
7MP0005360_urolithiasis2.66346799
8MP0005377_hearing/vestibular/ear_phenot2.54871500
9MP0003878_abnormal_ear_physiology2.54871500
10MP0003045_fibrosis2.23304766
11MP0001984_abnormal_olfaction2.14690864
12MP0002161_abnormal_fertility/fecundity2.07164792
13MP0005410_abnormal_fertilization11.5393065
14MP0003136_yellow_coat_color1.94412639
15MP0002210_abnormal_sex_determination1.77099934
16MP0010386_abnormal_urinary_bladder1.76576241
17MP0005058_abnormal_lysosome_morphology1.68843141
18MP0005394_taste/olfaction_phenotype1.61448611
19MP0005499_abnormal_olfactory_system1.61448611
20MP0005647_abnormal_sex_gland1.58997215
21MP0001664_abnormal_digestion1.58129795
22MP0001145_abnormal_male_reproductive1.56123615
23MP0005670_abnormal_white_adipose1.52560933
24MP0001905_abnormal_dopamine_level1.51475812
25MP0003718_maternal_effect1.49612046
26MP0010368_abnormal_lymphatic_system1.49285832
27MP0005248_abnormal_Harderian_gland1.43326783
28MP0000653_abnormal_sex_gland1.40465134
29MP0006072_abnormal_retinal_apoptosis1.40197560
30MP0000678_abnormal_parathyroid_gland1.31225698
31MP0005187_abnormal_penis_morphology1.29611358
32MP0009697_abnormal_copulation1.29314165
33MP0002127_abnormal_cardiovascular_syste1.27842271
34MP0000538_abnormal_urinary_bladder1.27477450
35MP0002249_abnormal_larynx_morphology1.25824788
36MP0005389_reproductive_system_phenotype1.21759281
37MP0005395_other_phenotype1.16555277
38MP0003632_abnormal_nervous_system1.13948970
39MP0004084_abnormal_cardiac_muscle1.13489451
40MP0008995_early_reproductive_senescence1.13432516
41MP0000537_abnormal_urethra_morphology1.12849606
42MP0005646_abnormal_pituitary_gland1.10412479
43MP0003879_abnormal_hair_cell1.09890329
44MP0001501_abnormal_sleep_pattern1.03994753
45MP0001485_abnormal_pinna_reflex1.03392279
46MP0005253_abnormal_eye_physiology1.02549068
47MP0001486_abnormal_startle_reflex0.99497616
48MP0001188_hyperpigmentation0.95347190
49MP0002168_other_aberrant_phenotype0.95322302
50MP0003631_nervous_system_phenotype0.92905948
51MP0004085_abnormal_heartbeat0.91125116
52MP0001348_abnormal_lacrimal_gland0.90840580
53MP0004859_abnormal_synaptic_plasticity0.90100987
54MP0006036_abnormal_mitochondrial_physio0.84518789
55MP0003936_abnormal_reproductive_system0.84174258
56MP0004036_abnormal_muscle_relaxation0.83300770
57MP0005379_endocrine/exocrine_gland_phen0.82684773
58MP0001849_ear_inflammation0.81947463
59MP0001270_distended_abdomen0.79604234
60MP0003633_abnormal_nervous_system0.77858323
61MP0002282_abnormal_trachea_morphology0.75017889
62MP0010234_abnormal_vibrissa_follicle0.74856667
63MP0001968_abnormal_touch/_nociception0.73990829
64MP0000470_abnormal_stomach_morphology0.73877354
65MP0000465_gastrointestinal_hemorrhage0.73378526
66MP0002138_abnormal_hepatobiliary_system0.73109214
67MP0008789_abnormal_olfactory_epithelium0.72365417
68MP0005551_abnormal_eye_electrophysiolog0.71377603
69MP0005595_abnormal_vascular_smooth0.69880267
70MP0004272_abnormal_basement_membrane0.69808760
71MP0001963_abnormal_hearing_physiology0.69579756
72MP0000230_abnormal_systemic_arterial0.68267017
73MP0002272_abnormal_nervous_system0.67403111
74MP0000681_abnormal_thyroid_gland0.65887030
75MP0000026_abnormal_inner_ear0.63599382
76MP0009046_muscle_twitch0.63408762
77MP0001529_abnormal_vocalization0.60139447
78MP0004381_abnormal_hair_follicle0.58788494
79MP0001756_abnormal_urination0.58678834
80MP0008877_abnormal_DNA_methylation0.58335770
81MP0005167_abnormal_blood-brain_barrier0.58179775
82MP0001765_abnormal_ion_homeostasis0.57187628
83MP0004484_altered_response_of0.57101944
84MP0000631_abnormal_neuroendocrine_gland0.55776547
85MP0001919_abnormal_reproductive_system0.55495673
86MP0002229_neurodegeneration0.54861717
87MP0002102_abnormal_ear_morphology0.52141249
88MP0003646_muscle_fatigue0.51908260
89MP0000343_altered_response_to0.51388553
90MP0000049_abnormal_middle_ear0.51293395
91MP0005166_decreased_susceptibility_to0.51102805
92MP0003385_abnormal_body_wall0.51052016
93MP0004782_abnormal_surfactant_physiolog0.50390871
94MP0002067_abnormal_sensory_capabilities0.47705177
95MP0003635_abnormal_synaptic_transmissio0.46838397
96MP0002115_abnormal_skeleton_extremities0.46615083
97MP0002837_dystrophic_cardiac_calcinosis0.46098252
98MP0005391_vision/eye_phenotype0.45506290
99MP0005423_abnormal_somatic_nervous0.44627525
100MP0005174_abnormal_tail_pigmentation0.41958474

Predicted human phenotypes

RankGene SetZ-score
1Resting tremor (HP:0002322)6.91674635
2Absent/shortened dynein arms (HP:0200106)6.77573454
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.77573454
4Sex reversal (HP:0012245)6.72265340
5Abnormal sex determination (HP:0012244)6.72265340
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.11360932
7Abnormal respiratory motile cilium physiology (HP:0012261)5.97268206
8Abnormal ciliary motility (HP:0012262)5.95016459
9Abnormal respiratory epithelium morphology (HP:0012253)4.97267228
10Abnormal respiratory motile cilium morphology (HP:0005938)4.97267228
11Hypoplasia of the uterus (HP:0000013)4.93286781
12Infertility (HP:0000789)4.79455926
13Postural instability (HP:0002172)4.41790278
14Gonadal dysgenesis (HP:0000133)4.38514661
15Abnormality of the columella (HP:0009929)4.32174189
16Aplasia/hypoplasia of the uterus (HP:0008684)3.95271979
17Tubulointerstitial nephritis (HP:0001970)3.93216991
18Nasal polyposis (HP:0100582)3.92666799
19Reduced antithrombin III activity (HP:0001976)3.79868097
20Colitis (HP:0002583)3.77695806
21Male pseudohermaphroditism (HP:0000037)3.75601467
22Severe visual impairment (HP:0001141)3.64873596
23Ventricular fibrillation (HP:0001663)3.57211680
24Congenital sensorineural hearing impairment (HP:0008527)3.47233728
25Rhinitis (HP:0012384)3.45576894
26Cerebellar dysplasia (HP:0007033)3.38916962
27Abnormality of the nasal mucosa (HP:0000433)3.38312689
28Atonic seizures (HP:0010819)3.29509015
29Bony spicule pigmentary retinopathy (HP:0007737)3.17301336
30Chronic hepatic failure (HP:0100626)3.14977478
31Facial hemangioma (HP:0000329)3.14129330
32Germ cell neoplasia (HP:0100728)3.10377888
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.06736410
34Thoracolumbar scoliosis (HP:0002944)3.06627527
35Attenuation of retinal blood vessels (HP:0007843)2.92363088
36Sensory axonal neuropathy (HP:0003390)2.91333514
37Inflammation of the large intestine (HP:0002037)2.91306456
38Type II lissencephaly (HP:0007260)2.88787334
39Abnormality of macular pigmentation (HP:0008002)2.87998540
40Abnormal rod and cone electroretinograms (HP:0008323)2.85597419
41Bronchiectasis (HP:0002110)2.64798092
42Gastrointestinal inflammation (HP:0004386)2.61832642
43Thoracic kyphosis (HP:0002942)2.55418678
44Self-mutilation (HP:0000742)2.55148196
45Retinal atrophy (HP:0001105)2.54123875
46Occipital encephalocele (HP:0002085)2.53872329
47Chronic bronchitis (HP:0004469)2.48768073
48Retinal dysplasia (HP:0007973)2.44886935
49Asymmetric septal hypertrophy (HP:0001670)2.41102998
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.40000896
51Renal dysplasia (HP:0000110)2.31153990
52Abnormal drinking behavior (HP:0030082)2.28005374
53Polydipsia (HP:0001959)2.28005374
54Abnormality of dental color (HP:0011073)2.19656510
55Abnormality of the intrinsic pathway (HP:0010989)2.17042732
56Urinary urgency (HP:0000012)2.16916100
57Prolonged QT interval (HP:0001657)2.15164999
58Capillary hemangiomas (HP:0005306)2.08522525
59Atrial fibrillation (HP:0005110)2.07637145
60Male infertility (HP:0003251)2.03703292
61Inability to walk (HP:0002540)2.01247464
62Anterior segment dysgenesis (HP:0007700)1.99417851
63Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99171952
64Syncope (HP:0001279)1.98876970
65Flattened epiphyses (HP:0003071)1.98660239
66Primary atrial arrhythmia (HP:0001692)1.97786439
67Progressive cerebellar ataxia (HP:0002073)1.96791002
68Hypothermia (HP:0002045)1.94143800
69Buphthalmos (HP:0000557)1.93125830
70Protruding tongue (HP:0010808)1.92919961
71Optic nerve hypoplasia (HP:0000609)1.92521107
72Abnormality of the lumbar spine (HP:0100712)1.92391609
73Azoospermia (HP:0000027)1.89264419
74Abnormality of the frontal sinuses (HP:0002687)1.88546917
75Median cleft lip (HP:0000161)1.87223452
76Abnormal EKG (HP:0003115)1.84196468
77Supraventricular tachycardia (HP:0004755)1.83874022
78Absent thumb (HP:0009777)1.82473044
79Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.81307443
80Impulsivity (HP:0100710)1.79600290
81Chronic sinusitis (HP:0011109)1.78661359
82Supraventricular arrhythmia (HP:0005115)1.76923222
83Abnormal urine output (HP:0012590)1.76512852
84Hyperkalemia (HP:0002153)1.75341738
85Nephronophthisis (HP:0000090)1.75321384
86Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74448011
87Unsteady gait (HP:0002317)1.67992749
88Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67492761
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67492761
90Recurrent corneal erosions (HP:0000495)1.65940037
91Spinal rigidity (HP:0003306)1.63146446
92Stage 5 chronic kidney disease (HP:0003774)1.62131686
93Polyuria (HP:0000103)1.61649579
94Photophobia (HP:0000613)1.59855550
95Abnormality of renal excretion (HP:0011036)1.59475205
96Facial diplegia (HP:0001349)1.57998152
97Cystic liver disease (HP:0006706)1.57603510
98Polyneuropathy (HP:0001271)1.57438965
99Hypoalphalipoproteinemia (HP:0003233)1.56895747
100Type II diabetes mellitus (HP:0005978)1.56868961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.52607169
2PLK43.50337551
3ZAK3.34469311
4TLK13.28819190
5MYLK2.75153689
6STK382.53156647
7STK38L2.41326968
8RPS6KA52.35174125
9NEK22.21891858
10LATS12.17273119
11PINK110.0079605
12FRK1.92230303
13INSRR1.82345356
14BRD41.60742365
15MAP2K71.53298586
16MAP4K21.46382460
17MAPK151.45254581
18MAP3K91.43769274
19MST1R1.32092667
20CDK31.24713553
21DDR21.23576321
22SGK4941.23498079
23SGK2231.23498079
24LATS21.16082207
25PLK21.13791954
26DYRK31.12071444
27TESK11.11092414
28FGFR21.07625100
29BMPR1B1.05763041
30NLK0.95842719
31PDPK10.93121932
32PDK10.90381563
33PIK3CG0.86778245
34PRKG20.85769037
35TIE10.85049155
36CSNK1A1L0.84610992
37CSNK1G30.84239935
38PRKD30.84038522
39ARAF0.83687591
40CSNK1G10.83649265
41PTK2B0.82303240
42PRKCQ0.79364271
43MAP3K10.75468420
44OBSCN0.72635073
45MAP3K130.67628320
46CAMK1G0.58797658
47CSNK1G20.58459558
48PNCK0.56962717
49CDK120.55893626
50CDK140.55102240
51KSR20.54995567
52PRKG10.53351226
53WNK10.52456894
54ROCK10.51656995
55CDC42BPA0.51480615
56VRK10.51333881
57SGK20.47732757
58MAP3K20.47338446
59CAMK10.41262598
60PAK10.40710979
61PKN10.38902625
62PAK20.36239706
63GRK10.35584303
64MOS0.34939572
65ADRBK20.34540209
66TGFBR10.33850440
67CDK50.33623579
68RPS6KA10.33158479
69RET0.32709337
70CSNK1A10.31899389
71EGFR0.30433552
72MELK0.30217765
73WNK30.29496628
74DYRK20.29319522
75RPS6KB10.28379914
76FGR0.27163921
77BRAF0.27124376
78DAPK30.26108304
79ATM0.25807056
80MTOR0.24614327
81GRK60.24184897
82STK30.23817307
83TYRO30.23427363
84MAPK10.22543718
85IRAK20.22292230
86CDK80.21992965
87NEK60.21892484
88TNIK0.21193772
89FGFR30.20159583
90MAP3K100.19713068
91TRPM70.16832705
92CAMK40.16661750
93AKT20.16494654
94RPS6KA30.14168239
95RPS6KA20.12678426
96MAP3K80.12527840
97GSK3B0.11776486
98SGK30.11536338
99CSNK1D0.11113143
100MAP3K50.10955238

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051306.24447201
2Gap junction_Homo sapiens_hsa045404.36838478
3Olfactory transduction_Homo sapiens_hsa047403.50710259
4Nitrogen metabolism_Homo sapiens_hsa009103.36694710
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28821173
6Hedgehog signaling pathway_Homo sapiens_hsa043403.00118720
7Arginine biosynthesis_Homo sapiens_hsa002202.98079444
8Butanoate metabolism_Homo sapiens_hsa006502.62378064
9Systemic lupus erythematosus_Homo sapiens_hsa053222.54002223
10Fatty acid biosynthesis_Homo sapiens_hsa000612.48895304
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.40950805
12Phagosome_Homo sapiens_hsa041452.30689714
13Apoptosis_Homo sapiens_hsa042102.16644283
14Alcoholism_Homo sapiens_hsa050342.08241131
15Dorso-ventral axis formation_Homo sapiens_hsa043202.06405428
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.98035835
17Taste transduction_Homo sapiens_hsa047421.51621637
18Propanoate metabolism_Homo sapiens_hsa006401.43702132
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31982927
20Phenylalanine metabolism_Homo sapiens_hsa003601.28236181
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.27278331
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.23557663
23Renin secretion_Homo sapiens_hsa049241.22789070
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05754866
25Oocyte meiosis_Homo sapiens_hsa041141.03373718
26Glucagon signaling pathway_Homo sapiens_hsa049221.02265508
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01922502
28Glycerophospholipid metabolism_Homo sapiens_hsa005640.99226751
29Chemical carcinogenesis_Homo sapiens_hsa052040.99020165
30Glutathione metabolism_Homo sapiens_hsa004800.96259223
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87896653
32PPAR signaling pathway_Homo sapiens_hsa033200.87145763
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86930829
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85663349
35Oxytocin signaling pathway_Homo sapiens_hsa049210.83955039
36Circadian rhythm_Homo sapiens_hsa047100.81848014
37Phototransduction_Homo sapiens_hsa047440.81669003
38Fatty acid degradation_Homo sapiens_hsa000710.79319524
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77922550
40Gastric acid secretion_Homo sapiens_hsa049710.76027650
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75552748
42Circadian entrainment_Homo sapiens_hsa047130.75047017
43Calcium signaling pathway_Homo sapiens_hsa040200.75002963
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73567807
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67002238
46Salivary secretion_Homo sapiens_hsa049700.64886552
47Pyruvate metabolism_Homo sapiens_hsa006200.62480826
48Amphetamine addiction_Homo sapiens_hsa050310.62225977
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62092772
50Tyrosine metabolism_Homo sapiens_hsa003500.61699051
51mRNA surveillance pathway_Homo sapiens_hsa030150.60517621
52Synaptic vesicle cycle_Homo sapiens_hsa047210.57434965
53Purine metabolism_Homo sapiens_hsa002300.57004897
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55960915
55Type II diabetes mellitus_Homo sapiens_hsa049300.55699583
56Long-term potentiation_Homo sapiens_hsa047200.54869965
57RNA transport_Homo sapiens_hsa030130.52951865
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52908119
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52572769
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51846047
61Basal transcription factors_Homo sapiens_hsa030220.51718954
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51200932
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47417784
64Tryptophan metabolism_Homo sapiens_hsa003800.46121093
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45849956
66Retinol metabolism_Homo sapiens_hsa008300.45484527
67Estrogen signaling pathway_Homo sapiens_hsa049150.43889181
68beta-Alanine metabolism_Homo sapiens_hsa004100.43027849
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42854802
70cAMP signaling pathway_Homo sapiens_hsa040240.40840217
71Fatty acid metabolism_Homo sapiens_hsa012120.39228981
72Type I diabetes mellitus_Homo sapiens_hsa049400.37689337
73GABAergic synapse_Homo sapiens_hsa047270.35239148
74TGF-beta signaling pathway_Homo sapiens_hsa043500.34916966
75Protein digestion and absorption_Homo sapiens_hsa049740.34226838
76MAPK signaling pathway_Homo sapiens_hsa040100.32013235
77Insulin secretion_Homo sapiens_hsa049110.31509304
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31028861
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30320684
80Fanconi anemia pathway_Homo sapiens_hsa034600.29971207
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.28923502
82Wnt signaling pathway_Homo sapiens_hsa043100.28245027
83Glutamatergic synapse_Homo sapiens_hsa047240.26627606
84Endometrial cancer_Homo sapiens_hsa052130.25481558
85ABC transporters_Homo sapiens_hsa020100.25393169
86Arginine and proline metabolism_Homo sapiens_hsa003300.23269680
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.23253049
88Metabolic pathways_Homo sapiens_hsa011000.21892894
89T cell receptor signaling pathway_Homo sapiens_hsa046600.21793667
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20797553
91Choline metabolism in cancer_Homo sapiens_hsa052310.19943456
92Inositol phosphate metabolism_Homo sapiens_hsa005620.19358946
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19172037
94Prostate cancer_Homo sapiens_hsa052150.19088388
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18624653
96B cell receptor signaling pathway_Homo sapiens_hsa046620.18431064
97VEGF signaling pathway_Homo sapiens_hsa043700.18023715
98Glycerolipid metabolism_Homo sapiens_hsa005610.17564514
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16350889
100Selenocompound metabolism_Homo sapiens_hsa004500.16259244

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