CCDC180

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a coiled-coil domain. Alternative splicing results in multiple transcript variants encoding different isoforms. A single nucleotide polymorphism (SNP) in this gene has been associated with increased susceptibility to Behcet's Disease (PMID: 19442274). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.85869401
2ventricular system development (GO:0021591)8.77154260
3positive regulation of synaptic transmission, dopaminergic (GO:0032226)8.64322567
4regulation of phosphoprotein phosphatase activity (GO:0043666)8.50671500
5GTP biosynthetic process (GO:0006183)8.40874960
6positive regulation of catecholamine secretion (GO:0033605)8.26988774
7regulation of cilium movement (GO:0003352)8.26654538
8sperm motility (GO:0030317)8.12560505
9nucleoside diphosphate phosphorylation (GO:0006165)7.68139035
10multicellular organism reproduction (GO:0032504)7.49036619
11UTP biosynthetic process (GO:0006228)7.49008066
12piRNA metabolic process (GO:0034587)7.33814262
13acrosome assembly (GO:0001675)7.18564151
14sperm-egg recognition (GO:0035036)6.98533425
15UTP metabolic process (GO:0046051)6.72368312
16plasma membrane fusion (GO:0045026)6.66635156
17spermatid development (GO:0007286)6.52524607
18left/right axis specification (GO:0070986)6.50825833
19binding of sperm to zona pellucida (GO:0007339)6.38486504
20cell-cell recognition (GO:0009988)6.24615437
21acrosome reaction (GO:0007340)6.14458298
22male meiosis (GO:0007140)6.06254669
23reproduction (GO:0000003)5.94615203
24guanosine-containing compound biosynthetic process (GO:1901070)5.77337785
25regulation of oxidative stress-induced neuron death (GO:1903203)5.74950718
26cell wall macromolecule catabolic process (GO:0016998)5.74725161
27cell wall macromolecule metabolic process (GO:0044036)5.74725161
28intraciliary transport (GO:0042073)5.74211716
29CTP biosynthetic process (GO:0006241)5.72781160
30CTP metabolic process (GO:0046036)5.72781160
31single fertilization (GO:0007338)5.63786174
32relaxation of smooth muscle (GO:0044557)5.38319070
33synaptonemal complex organization (GO:0070193)5.33548841
34pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)5.23285025
35potassium ion export (GO:0071435)5.21736318
36cilium organization (GO:0044782)5.17050429
37male meiosis I (GO:0007141)5.14173147
38negative regulation of inclusion body assembly (GO:0090084)5.13512731
39regulation of oxidative phosphorylation (GO:0002082)5.11613551
40microtubule severing (GO:0051013)4.94094315
41protein-DNA complex disassembly (GO:0032986)4.89841871
42nucleosome disassembly (GO:0006337)4.89841871
43synapsis (GO:0007129)4.89453661
44fertilization (GO:0009566)4.86424406
45regulation of microtubule-based movement (GO:0060632)4.82657665
46pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.79912899
47cilium assembly (GO:0042384)4.77386017
48microtubule bundle formation (GO:0001578)4.77074637
49meiotic cell cycle (GO:0051321)4.64965097
50microtubule-based movement (GO:0007018)4.62215256
51regulation of autophagic vacuole assembly (GO:2000785)4.57554465
52pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.54255402
53activation of protein kinase B activity (GO:0032148)4.51714293
54male sex determination (GO:0030238)4.51329441
55Leydig cell differentiation (GO:0033327)4.49664768
56DNA methylation involved in gamete generation (GO:0043046)4.49256164
57synaptonemal complex assembly (GO:0007130)4.41901674
58cGMP-mediated signaling (GO:0019934)4.38997418
59androgen biosynthetic process (GO:0006702)4.38569522
60cellular component assembly involved in morphogenesis (GO:0010927)4.31535759
61regulation of inclusion body assembly (GO:0090083)4.30076072
62spermatogenesis (GO:0007283)4.29975716
63male gamete generation (GO:0048232)4.27866102
64cilium morphogenesis (GO:0060271)4.27414384
65regulation of dopamine secretion (GO:0014059)4.27243489
66protein localization to cilium (GO:0061512)4.26523138
67nucleotide phosphorylation (GO:0046939)4.26309549
68sperm capacitation (GO:0048240)4.21470136
69positive regulation of glycolytic process (GO:0045821)4.13963375
70polyamine biosynthetic process (GO:0006596)4.10629736
71coenzyme catabolic process (GO:0009109)4.06724188
72meiosis I (GO:0007127)4.03734792
73tongue development (GO:0043586)4.03197600
74negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.97647205
75gamete generation (GO:0007276)3.93989351
76centriole replication (GO:0007099)3.93774721
77pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.90992364
78left/right pattern formation (GO:0060972)3.85904702
79tryptophan catabolic process (GO:0006569)3.81921368
80indole-containing compound catabolic process (GO:0042436)3.81921368
81indolalkylamine catabolic process (GO:0046218)3.81921368
82mitochondrion degradation (GO:0000422)3.78970325
83regulation of vacuole organization (GO:0044088)3.78010519
84TOR signaling (GO:0031929)3.74911012
85nucleoside diphosphate metabolic process (GO:0009132)3.72102193
86centriole assembly (GO:0098534)3.72079861
87glutamine family amino acid catabolic process (GO:0009065)3.69457026
88protein polymerization (GO:0051258)3.68241526
89regulation of hydrogen peroxide-induced cell death (GO:1903205)3.67708806
90germ cell development (GO:0007281)3.65611689
91phosphatidylethanolamine biosynthetic process (GO:0006646)3.62964159
92negative regulation of response to reactive oxygen species (GO:1901032)3.59705167
93membrane repolarization during action potential (GO:0086011)3.59538936
94regulation of synaptic transmission, dopaminergic (GO:0032225)3.58179211
95organic cation transport (GO:0015695)3.56642947
96spermatid nucleus differentiation (GO:0007289)3.55864414
97otic vesicle formation (GO:0030916)3.55271552
98meiotic nuclear division (GO:0007126)3.54591622
99negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.51549375
100cellular process involved in reproduction in multicellular organism (GO:0022412)3.50610084
101positive regulation of amine transport (GO:0051954)3.40826765
102phosphatidylethanolamine metabolic process (GO:0046337)3.36503535
103cell projection assembly (GO:0030031)3.34513721
104response to acidic pH (GO:0010447)3.32920886
105glycogen metabolic process (GO:0005977)3.32408253
106cellular glucan metabolic process (GO:0006073)3.28657221
107glucan metabolic process (GO:0044042)3.28657221
108oogenesis (GO:0048477)3.26193777
109regulation of phosphatase activity (GO:0010921)3.25937565
110cellular response to toxic substance (GO:0097237)3.24449847
111protein polyglutamylation (GO:0018095)3.24221143
112determination of left/right symmetry (GO:0007368)3.24180441
113regulation of cellular respiration (GO:0043457)3.23711193
114chromosome organization involved in meiosis (GO:0070192)3.22388663
115oligosaccharide biosynthetic process (GO:0009312)3.21712089
116DNA double-strand break processing (GO:0000729)3.18904332
117cellular biogenic amine biosynthetic process (GO:0042401)3.16979964
118amine biosynthetic process (GO:0009309)3.15670809
119pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.12615012
120negative regulation of JNK cascade (GO:0046329)3.11462597
121regulation of macrophage chemotaxis (GO:0010758)3.10985859
122aspartate family amino acid catabolic process (GO:0009068)3.10711559
123multicellular organismal reproductive process (GO:0048609)3.09173503
124determination of bilateral symmetry (GO:0009855)3.08955223
125deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.08633418
126membrane repolarization (GO:0086009)3.06611138
127histone exchange (GO:0043486)3.04546617
128specification of symmetry (GO:0009799)3.00046957
129cell recognition (GO:0008037)2.99566970
130genitalia morphogenesis (GO:0035112)2.97531745
131glutathione derivative biosynthetic process (GO:1901687)2.96420043
132glutathione derivative metabolic process (GO:1901685)2.96420043
133pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.94739677
134detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.93660938
135diacylglycerol metabolic process (GO:0046339)2.93085658
136retinal cone cell development (GO:0046549)2.92450668
137tryptophan metabolic process (GO:0006568)2.91796532
138negative regulation of reactive oxygen species metabolic process (GO:2000378)2.91459431
139brain morphogenesis (GO:0048854)2.88399783
140protein refolding (GO:0042026)2.83276064
141photoreceptor cell differentiation (GO:0046530)2.82449911
142eye photoreceptor cell differentiation (GO:0001754)2.82449911
143purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75459726
144regulation of meiosis I (GO:0060631)2.75124440
145regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70978504
146regulation of mononuclear cell migration (GO:0071675)2.70374809
147intra-S DNA damage checkpoint (GO:0031573)2.65493388
148pyrimidine ribonucleotide metabolic process (GO:0009218)2.65384986
149purine nucleoside triphosphate biosynthetic process (GO:0009145)2.65245444
150microtubule depolymerization (GO:0007019)2.64593353
151calcium ion-dependent exocytosis (GO:0017156)2.59360250
152microtubule-based process (GO:0007017)2.58444895
153regulation of RNA export from nucleus (GO:0046831)2.54629287
154cilium or flagellum-dependent cell motility (GO:0001539)18.2178316
155axonemal dynein complex assembly (GO:0070286)16.4915598
156cilium movement (GO:0003341)15.2944363
157epithelial cilium movement (GO:0003351)12.4129927
158motile cilium assembly (GO:0044458)10.9252968
159epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.6024872
160axoneme assembly (GO:0035082)10.5437709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.37529935
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.13757036
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.72338833
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.44181577
5IGF1R_20145208_ChIP-Seq_DFB_Human4.34285708
6EZH2_22144423_ChIP-Seq_EOC_Human4.02080597
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.63981037
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60920742
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.12287318
10GBX2_23144817_ChIP-Seq_PC3_Human2.62970247
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.58039989
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54492446
13VDR_22108803_ChIP-Seq_LS180_Human2.50600299
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.45434275
15FUS_26573619_Chip-Seq_HEK293_Human2.29984195
16AR_21572438_ChIP-Seq_LNCaP_Human2.29008976
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.19681393
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.19327757
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.18158238
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14242811
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10866696
22ARNT_22903824_ChIP-Seq_MCF-7_Human2.03847112
23AHR_22903824_ChIP-Seq_MCF-7_Human2.03053850
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98612100
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94590292
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89070773
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.81148926
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74328756
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61290281
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.60243600
31P300_19829295_ChIP-Seq_ESCs_Human1.60233724
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59905732
33STAT1_17558387_ChIP-Seq_HELA_Human1.57867599
34ZNF274_21170338_ChIP-Seq_K562_Hela1.56236837
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.55855583
36RNF2_27304074_Chip-Seq_NSC_Mouse1.55659908
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54475860
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52674232
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51354983
40TAL1_26923725_Chip-Seq_HPCs_Mouse1.49897604
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.48346261
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46247136
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.45071898
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42912536
45CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42780320
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.42754532
47OCT1_27270436_Chip-Seq_PROSTATE_Human1.40441547
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.40354146
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39947691
50RUNX2_22187159_ChIP-Seq_PCA_Human1.39522480
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37545114
52SMAD4_21799915_ChIP-Seq_A2780_Human1.37426263
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36844280
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36754641
55STAT3_23295773_ChIP-Seq_U87_Human1.36391098
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35612782
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35611822
58TP53_18474530_ChIP-ChIP_U2OS_Human1.33917209
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.32370485
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32225270
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31515311
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30995310
63AR_25329375_ChIP-Seq_VCAP_Human1.30974236
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29412161
65CBP_20019798_ChIP-Seq_JUKART_Human1.29412161
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.27196522
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26540605
68ERA_21632823_ChIP-Seq_H3396_Human1.26140863
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.25604181
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.25015898
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.24532332
72ERG_20517297_ChIP-Seq_VCAP_Human1.24168771
73ER_23166858_ChIP-Seq_MCF-7_Human1.24020278
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23686892
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22891299
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22891299
77OCT4_20526341_ChIP-Seq_ESCs_Human1.22380577
78P53_22387025_ChIP-Seq_ESCs_Mouse1.20757322
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20677214
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20592961
81MYC_19829295_ChIP-Seq_ESCs_Human1.19798172
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19411919
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18434319
84SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16751763
85NANOG_19829295_ChIP-Seq_ESCs_Human1.15907326
86SOX2_19829295_ChIP-Seq_ESCs_Human1.15907326
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15433991
88GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15260414
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15198527
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.14771999
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13907369
92GF1_26923725_Chip-Seq_HPCs_Mouse1.13788187
93ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13204757
94BCAT_22108803_ChIP-Seq_LS180_Human1.13088583
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13023379
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.13023379
97RXR_22108803_ChIP-Seq_LS180_Human1.12998474
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10853797
99PU1_27457419_Chip-Seq_LIVER_Mouse1.10547804
100P300_18555785_Chip-Seq_ESCs_Mouse1.10449895
101KDM2B_26808549_Chip-Seq_REH_Human1.09790658
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09742929
103RAC3_21632823_ChIP-Seq_H3396_Human1.09374760
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09188719
105P53_21459846_ChIP-Seq_SAOS-2_Human1.09117721
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08755691
107EWS_26573619_Chip-Seq_HEK293_Human1.08613929
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08467607
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07407264
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.07322964
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07299877
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05750337
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.05629405
114TBL1_22424771_ChIP-Seq_293T_Human1.05619114
115POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05189782
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04647122
117CTCF_27219007_Chip-Seq_Bcells_Human1.04186176
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.04174199
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.03698568
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02795320
121DROSHA_22980978_ChIP-Seq_HELA_Human1.02594430
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02203043
123TCF4_22108803_ChIP-Seq_LS180_Human1.02056227
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02039772
125LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01584590
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.01217229
127TCF4_23295773_ChIP-Seq_U87_Human1.00037346
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.99659975
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99564489
130SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98940913
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98912258
132GATA3_21867929_ChIP-Seq_CD8_Mouse0.97785760
133HOXB7_26014856_ChIP-Seq_BT474_Human0.97354202
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97258815
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96645827
136NFYB_21822215_ChIP-Seq_K562_Human0.96316889
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96222875
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96101447
139PHF8_20622853_ChIP-Seq_HELA_Human0.95324544
140GATA3_21867929_ChIP-Seq_TH1_Mouse0.94835999
141CDX2_22108803_ChIP-Seq_LS180_Human0.94207988
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93392685
143SMRT_27268052_Chip-Seq_Bcells_Human0.92660670
144CTCF_18555785_Chip-Seq_ESCs_Mouse0.92287948
145LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92245948
146CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91624222
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91618662
148RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91596051
149NANOG_20526341_ChIP-Seq_ESCs_Human0.91110538
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90717814
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90711992
152SMC4_20622854_ChIP-Seq_HELA_Human0.90558130
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.90532934
154FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90364879
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89806766
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89176732
157EED_16625203_ChIP-ChIP_MESCs_Mouse0.88934982
158TP63_23658742_ChIP-Seq_EP156T_Human0.88748453
159ETV1_20927104_ChIP-Seq_GIST48_Human0.88476557
160TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87826265
161TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87580980
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.87450903
163GATA3_21878914_ChIP-Seq_MCF-7_Human0.86961773
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.86279701
165EZH2_27294783_Chip-Seq_ESCs_Mouse0.86128882
166HNFA_21074721_ChIP-Seq_CACO-2_Human0.86033191
167NFYA_21822215_ChIP-Seq_K562_Human0.85194397
168CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84406113
169RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84312002
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83439092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.84971905
2MP0003315_abnormal_perineum_morphology5.41939458
3MP0003136_yellow_coat_color4.78159968
4MP0003698_abnormal_male_reproductive4.26672807
5MP0001929_abnormal_gametogenesis4.00513427
6MP0002653_abnormal_ependyma_morphology3.82838074
7MP0008877_abnormal_DNA_methylation3.34565514
8MP0005623_abnormal_meninges_morphology3.09101141
9MP0005551_abnormal_eye_electrophysiolog3.03776355
10MP0005360_urolithiasis2.92028073
11MP0001986_abnormal_taste_sensitivity2.90838225
12MP0002210_abnormal_sex_determination2.77228749
13MP0003950_abnormal_plasma_membrane2.62290596
14MP0002132_abnormal_respiratory_system2.60914792
15MP0003011_delayed_dark_adaptation2.53022234
16MP0005253_abnormal_eye_physiology2.50201546
17MP0002160_abnormal_reproductive_system2.35947909
18MP0002102_abnormal_ear_morphology2.34570710
19MP0005499_abnormal_olfactory_system2.27080150
20MP0005394_taste/olfaction_phenotype2.27080150
21MP0002161_abnormal_fertility/fecundity2.24585510
22MP0001145_abnormal_male_reproductive2.18867844
23MP0006072_abnormal_retinal_apoptosis2.16956283
24MP0010386_abnormal_urinary_bladder2.08061301
25MP0000653_abnormal_sex_gland2.02740245
26MP0001664_abnormal_digestion1.92351105
27MP0002928_abnormal_bile_duct1.85514347
28MP0008004_abnormal_stomach_pH1.80335525
29MP0002282_abnormal_trachea_morphology1.78974060
30MP0000537_abnormal_urethra_morphology1.75223728
31MP0001984_abnormal_olfaction1.74039460
32MP0001188_hyperpigmentation1.71984296
33MP0005187_abnormal_penis_morphology1.71750621
34MP0004381_abnormal_hair_follicle1.63318748
35MP0003724_increased_susceptibility_to1.61237135
36MP0008995_early_reproductive_senescence1.58823025
37MP0005423_abnormal_somatic_nervous1.51103204
38MP0001905_abnormal_dopamine_level1.50236625
39MP0008789_abnormal_olfactory_epithelium1.48435585
40MP0001501_abnormal_sleep_pattern1.46195444
41MP0009046_muscle_twitch1.43651898
42MP0005647_abnormal_sex_gland1.42474613
43MP0005389_reproductive_system_phenotype1.41897659
44MP0002405_respiratory_system_inflammati1.39840385
45MP0000538_abnormal_urinary_bladder1.39816825
46MP0005391_vision/eye_phenotype1.38629772
47MP0000631_abnormal_neuroendocrine_gland1.35992625
48MP0003878_abnormal_ear_physiology1.33726313
49MP0005377_hearing/vestibular/ear_phenot1.33726313
50MP0002277_abnormal_respiratory_mucosa1.31367868
51MP0005670_abnormal_white_adipose1.29335351
52MP0008875_abnormal_xenobiotic_pharmacok1.28199971
53MP0001851_eye_inflammation1.26417094
54MP0005058_abnormal_lysosome_morphology1.25191820
55MP0008057_abnormal_DNA_replication1.19946544
56MP0004133_heterotaxia1.19732959
57MP0005248_abnormal_Harderian_gland1.18644564
58MP0001765_abnormal_ion_homeostasis1.16785116
59MP0001485_abnormal_pinna_reflex1.15090180
60MP0002272_abnormal_nervous_system1.11449302
61MP0001968_abnormal_touch/_nociception1.11097813
62MP0003303_peritoneal_inflammation1.11010515
63MP0005195_abnormal_posterior_eye1.10425543
64MP0005397_hematopoietic_system_phenotyp1.09510349
65MP0001545_abnormal_hematopoietic_system1.09510349
66MP0005395_other_phenotype1.09118593
67MP0003646_muscle_fatigue1.06037709
68MP0003632_abnormal_nervous_system1.05102041
69MP0000465_gastrointestinal_hemorrhage1.04979912
70MP0004085_abnormal_heartbeat1.02880060
71MP0003718_maternal_effect1.02607715
72MP0005646_abnormal_pituitary_gland1.02037913
73MP0001486_abnormal_startle_reflex0.98275036
74MP0002638_abnormal_pupillary_reflex0.95805434
75MP0002233_abnormal_nose_morphology0.94195194
76MP0008058_abnormal_DNA_repair0.92636564
77MP0003936_abnormal_reproductive_system0.90963199
78MP0003631_nervous_system_phenotype0.90533453
79MP0009745_abnormal_behavioral_response0.89981018
80MP0005167_abnormal_blood-brain_barrier0.89384380
81MP0005075_abnormal_melanosome_morpholog0.87927389
82MP0004808_abnormal_hematopoietic_stem0.85835222
83MP0004084_abnormal_cardiac_muscle0.84491699
84MP0003635_abnormal_synaptic_transmissio0.84017734
85MP0005388_respiratory_system_phenotype0.82073016
86MP0002133_abnormal_respiratory_system0.82073016
87MP0003633_abnormal_nervous_system0.82042102
88MP0009697_abnormal_copulation0.81760083
89MP0000470_abnormal_stomach_morphology0.80470125
90MP0001849_ear_inflammation0.79496390
91MP0001529_abnormal_vocalization0.78267728
92MP0004885_abnormal_endolymph0.77710694
93MP0001879_abnormal_lymphatic_vessel0.76452512
94MP0006276_abnormal_autonomic_nervous0.76235086
95MP0000026_abnormal_inner_ear0.76095193
96MP0000230_abnormal_systemic_arterial0.75441894
97MP0002064_seizures0.72439968
98MP0006036_abnormal_mitochondrial_physio0.71927581
99MP0000049_abnormal_middle_ear0.71897819
100MP0001963_abnormal_hearing_physiology0.71444202
101MP0005174_abnormal_tail_pigmentation0.71279204
102MP0003879_abnormal_hair_cell0.70112313
103MP0002148_abnormal_hypersensitivity_rea0.68765888
104MP0003690_abnormal_glial_cell0.68293414
105MP0001790_abnormal_immune_system0.67559985
106MP0005387_immune_system_phenotype0.67559985
107MP0002572_abnormal_emotion/affect_behav0.66954998
108MP0002735_abnormal_chemical_nociception0.66773230
109MP0001958_emphysema0.66293419
110MP0002295_abnormal_pulmonary_circulatio0.66226095
111MP0002249_abnormal_larynx_morphology0.64634731
112MP0000566_synostosis0.64337787
113MP0001324_abnormal_eye_pigmentation0.63793558
114MP0001502_abnormal_circadian_rhythm0.63369195
115MP0002557_abnormal_social/conspecific_i0.62358101
116MP0003634_abnormal_glial_cell0.61922074
117MP0003763_abnormal_thymus_physiology0.61100919
118MP0001756_abnormal_urination0.60749033
119MP0003436_decreased_susceptibility_to0.60677489
120MP0003938_abnormal_ear_development0.60234631
121MP0002332_abnormal_exercise_endurance0.60216258
122MP0001440_abnormal_grooming_behavior0.59768620
123MP0001835_abnormal_antigen_presentation0.59749415
124MP0001727_abnormal_embryo_implantation0.59114247
125MP0004036_abnormal_muscle_relaxation0.58267088
126MP0002168_other_aberrant_phenotype0.58063948
127MP0002067_abnormal_sensory_capabilities0.56870718
128MP0004782_abnormal_surfactant_physiolog0.55812655
129MP0002837_dystrophic_cardiac_calcinosis0.55339550
130MP0001970_abnormal_pain_threshold0.55071678
131MP0002419_abnormal_innate_immunity0.54467761
132MP0004043_abnormal_pH_regulation0.53726392
133MP0002095_abnormal_skin_pigmentation0.53312970
134MP0002229_neurodegeneration0.52579771
135MP0002127_abnormal_cardiovascular_syste0.52471685
136MP0002752_abnormal_somatic_nervous0.52343220
137MP0005025_abnormal_response_to0.51429427
138MP0005000_abnormal_immune_tolerance0.50273027
139MP0002234_abnormal_pharynx_morphology0.48218017
140MP0004134_abnormal_chest_morphology0.47850388
141MP0002089_abnormal_postnatal_growth/wei0.47675982
142MP0005595_abnormal_vascular_smooth0.46659478
143MP0001853_heart_inflammation0.42710878
144MP0001919_abnormal_reproductive_system0.41922357
145MP0001270_distended_abdomen0.40921131
146MP0005636_abnormal_mineral_homeostasis0.40322939
147MP0000685_abnormal_immune_system0.39981213
148MP0005310_abnormal_salivary_gland0.39715963
149MP0010368_abnormal_lymphatic_system0.39602427
150MP0001119_abnormal_female_reproductive0.38711921
151MP0002723_abnormal_immune_serum0.38401159
152MP0003937_abnormal_limbs/digits/tail_de0.38375538
153MP0009785_altered_susceptibility_to0.38012804
154MP0009250_abnormal_appendicular_skeleto0.37964589
155MP0005379_endocrine/exocrine_gland_phen0.37628913
156MP0005165_increased_susceptibility_to0.37325877
157MP0004145_abnormal_muscle_electrophysio0.37162291
158MP0003045_fibrosis0.36802690
159MP0001764_abnormal_homeostasis0.36097206
160MP0003786_premature_aging0.35771267

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.66315574
2Chronic bronchitis (HP:0004469)7.03365264
3Bronchiectasis (HP:0002110)6.11715764
4Nasal polyposis (HP:0100582)5.97545120
5Abnormality of the nasal mucosa (HP:0000433)5.13832066
6Infertility (HP:0000789)4.88212459
7Hypoplasia of the uterus (HP:0000013)4.72448114
8Recurrent sinusitis (HP:0011108)4.48227956
9Bronchitis (HP:0012387)4.22264163
10Resting tremor (HP:0002322)4.07813378
11Chronic sinusitis (HP:0011109)3.70433787
12Aplasia/hypoplasia of the uterus (HP:0008684)3.64886570
13Nephronophthisis (HP:0000090)3.60696237
14Abnormality of the columella (HP:0009929)3.55993139
15True hermaphroditism (HP:0010459)3.47649924
16Gonadal dysgenesis (HP:0000133)3.45262179
17Congenital stationary night blindness (HP:0007642)3.37914052
18Cerebellar dysplasia (HP:0007033)3.23720317
19Recurrent otitis media (HP:0000403)3.20419631
20Ventricular fibrillation (HP:0001663)3.16927454
21Male infertility (HP:0003251)3.11708652
22Reduced antithrombin III activity (HP:0001976)3.10120940
23Pancreatic fibrosis (HP:0100732)3.09251906
24Type II lissencephaly (HP:0007260)3.07550400
25Postural instability (HP:0002172)3.02694551
26Facial hemangioma (HP:0000329)2.87816305
27Medial flaring of the eyebrow (HP:0010747)2.83985753
28Abnormality of the renal medulla (HP:0100957)2.77618085
29Tubulointerstitial nephritis (HP:0001970)2.72550971
30Colitis (HP:0002583)2.64473717
31Supernumerary spleens (HP:0009799)2.59042923
32Molar tooth sign on MRI (HP:0002419)2.57709966
33Abnormality of midbrain morphology (HP:0002418)2.57709966
34Germ cell neoplasia (HP:0100728)2.51261861
35Protruding tongue (HP:0010808)2.49273017
36Congenital primary aphakia (HP:0007707)2.40985540
37Gait imbalance (HP:0002141)2.39593034
38Urinary urgency (HP:0000012)2.36824504
39Recurrent bronchitis (HP:0002837)2.34863429
40Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.29327942
41Congenital hepatic fibrosis (HP:0002612)2.28975103
42Retinal dysplasia (HP:0007973)2.26791645
43Occipital encephalocele (HP:0002085)2.22657507
44Self-mutilation (HP:0000742)2.22477286
45Thoracic kyphosis (HP:0002942)2.21145625
46Atonic seizures (HP:0010819)2.20618289
47Congenital sensorineural hearing impairment (HP:0008527)2.19795744
48Postaxial foot polydactyly (HP:0001830)2.18824378
49Abnormality of permanent molar morphology (HP:0011071)2.13929197
50Abnormality of the dental root (HP:0006486)2.13929197
51Taurodontia (HP:0000679)2.13929197
52Median cleft lip (HP:0000161)2.12474333
53Absent speech (HP:0001344)2.11972311
54Abnormality of dentin (HP:0010299)2.10764283
55Cystic liver disease (HP:0006706)2.09259043
56Fibular hypoplasia (HP:0003038)2.08234274
57Nephrogenic diabetes insipidus (HP:0009806)2.07581978
58Retinal atrophy (HP:0001105)2.05541406
59Abnormal biliary tract physiology (HP:0012439)2.04253418
60Bile duct proliferation (HP:0001408)2.04253418
61Abnormality of molar (HP:0011077)2.00542078
62Abnormality of molar morphology (HP:0011070)2.00542078
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9832005
64Abnormal respiratory motile cilium physiology (HP:0012261)12.3678961
65Abnormal ciliary motility (HP:0012262)11.8576171
66Dynein arm defect of respiratory motile cilia (HP:0012255)10.3344945
67Absent/shortened dynein arms (HP:0200106)10.3344945
68Abnormal respiratory motile cilium morphology (HP:0005938)10.0935534
69Abnormal respiratory epithelium morphology (HP:0012253)10.0935534
70Pancreatic cysts (HP:0001737)1.99871242
71Abnormality of the dental pulp (HP:0006479)1.96875801
7211 pairs of ribs (HP:0000878)1.94758215
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.92868634
74Tubulointerstitial abnormality (HP:0001969)1.92702645
75Inability to walk (HP:0002540)1.90625702
76Abnormality of the frontal sinuses (HP:0002687)1.90003418
77Thoracolumbar scoliosis (HP:0002944)1.89724637
78Bony spicule pigmentary retinopathy (HP:0007737)1.89161501
79Hypothermia (HP:0002045)1.87708667
80Stage 5 chronic kidney disease (HP:0003774)1.87157869
81Renal dysplasia (HP:0000110)1.81445681
82Tubular atrophy (HP:0000092)1.81124758
83Decreased central vision (HP:0007663)1.79218992
84Genital tract atresia (HP:0001827)1.77538044
85Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77278538
86Prolonged QT interval (HP:0001657)1.76854823
87Capillary hemangiomas (HP:0005306)1.75479230
88Poor coordination (HP:0002370)1.75076877
89Optic nerve hypoplasia (HP:0000609)1.73085969
90Vaginal atresia (HP:0000148)1.72255659
91Male pseudohermaphroditism (HP:0000037)1.69604575
92Furrowed tongue (HP:0000221)1.69575346
93Anterior segment dysgenesis (HP:0007700)1.65358921
94Abnormality of the intrinsic pathway (HP:0010989)1.64441360
95Facial cleft (HP:0002006)1.63578889
96Oculomotor apraxia (HP:0000657)1.63057057
97Inflammation of the large intestine (HP:0002037)1.62765957
98Chronic hepatic failure (HP:0100626)1.61268603
99Syncope (HP:0001279)1.60397071
100Absent thumb (HP:0009777)1.59004394
101Postaxial hand polydactyly (HP:0001162)1.57444758
102Febrile seizures (HP:0002373)1.56828561
103Buphthalmos (HP:0000557)1.56738614
104Abnormal sex determination (HP:0012244)1.54700839
105Sex reversal (HP:0012245)1.54700839
106Attenuation of retinal blood vessels (HP:0007843)1.53918018
107Sensory axonal neuropathy (HP:0003390)1.53429620
108Progressive cerebellar ataxia (HP:0002073)1.52596812
109Aplasia/Hypoplasia of the lens (HP:0008063)1.50539239
110Abnormal spermatogenesis (HP:0008669)1.50374554
111Abnormality of the lumbar spine (HP:0100712)1.50209817
112Preaxial hand polydactyly (HP:0001177)1.50103365
113Abnormality of male internal genitalia (HP:0000022)1.49347551
114Chronic obstructive pulmonary disease (HP:0006510)1.48082812
115Obstructive lung disease (HP:0006536)1.48082812
116Retinitis pigmentosa (HP:0000510)1.46831369
117Chronic otitis media (HP:0000389)1.45983388
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.43274511
119Gastrointestinal inflammation (HP:0004386)1.40385797
120Nephropathy (HP:0000112)1.38299807
121Polyuria (HP:0000103)1.36790826
122Enlarged kidneys (HP:0000105)1.36634095
123Esophageal neoplasm (HP:0100751)1.34596069
124Neoplasm of head and neck (HP:0012288)1.34596069
125Anencephaly (HP:0002323)1.33521328
126Tubulointerstitial fibrosis (HP:0005576)1.33179077
127Abdominal situs inversus (HP:0003363)1.32099375
128Abnormality of abdominal situs (HP:0011620)1.32099375
129Atelectasis (HP:0100750)1.30639314
130Short nail (HP:0001799)1.28305746
131Azoospermia (HP:0000027)1.27759105
132Abnormal rod and cone electroretinograms (HP:0008323)1.26609162
133Abnormality of the renal cortex (HP:0011035)1.24736647
134Polydipsia (HP:0001959)1.22790967
135Abnormal drinking behavior (HP:0030082)1.22790967
136Pigmentary retinal degeneration (HP:0001146)1.21826638
137Abnormality of macular pigmentation (HP:0008002)1.19382796
138Sclerocornea (HP:0000647)1.18067673
139Hypodontia (HP:0000668)1.16573645
140Aplasia/Hypoplasia of the fibula (HP:0006492)1.16449938
141Hypotelorism (HP:0000601)1.12666767
142Asplenia (HP:0001746)1.10372991
143Broad distal phalanx of finger (HP:0009836)1.10192343
144Short ribs (HP:0000773)1.09378386
145Type II diabetes mellitus (HP:0005978)1.09276341
146Dyschromatopsia (HP:0007641)1.07298445
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.04811845
148Recurrent gram-negative bacterial infections (HP:0005420)1.04230746
149Polycystic ovaries (HP:0000147)1.03881739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.21332189
2PDK36.21332189
3MAPK155.84798628
4MARK35.50680642
5PNCK5.43911798
6TLK13.91221666
7PDK23.78981262
8ZAK3.78950780
9TESK13.02228932
10FRK3.00326500
11PTK2B2.37502425
12GRK12.34349127
13LATS12.17416147
14ICK2.15236833
15PINK110.9236679
16CCNB11.95394739
17PRKD31.94930745
18STK38L1.76230487
19BLK1.63106022
20WEE11.61019124
21BMPR1B1.50079576
22STK101.44726760
23MUSK1.42946684
24WNK41.31570786
25NEK21.29130396
26SGK2231.27509313
27SGK4941.27509313
28VRK11.25120696
29IRAK11.24840958
30NTRK21.20265651
31STK391.12701329
32MST41.12656133
33CDK31.11380796
34PBK1.09917749
35STK31.08663872
36EEF2K1.04139542
37MAPKAPK51.02652074
38PAK20.96917037
39FGFR20.96149017
40RPS6KA40.93554628
41MYLK0.92615731
42CSNK1A1L0.92590338
43MAP2K60.86549449
44CSK0.84679305
45OBSCN0.81074791
46DYRK30.80007610
47IRAK20.76382281
48SRPK10.75710525
49MAP3K120.75472713
50ZAP700.74303971
51SGK20.71205865
52CSNK1G30.70811872
53CAMK1G0.70436752
54CDC42BPA0.69862204
55MAP4K10.68013901
56WNK30.67804134
57PIM20.66487485
58TTK0.65586617
59TIE10.65315339
60MKNK20.64505219
61INSRR0.64270347
62WNK10.63911771
63STK380.63792731
64DAPK20.63759381
65TEC0.62973314
66CSNK1G20.61637943
67CSNK1G10.61141120
68DYRK20.61075278
69TAOK30.60163486
70TXK0.59678688
71PKN10.56968859
72FES0.56314906
73PIK3CG0.56207784
74KIT0.53424237
75TGFBR10.53190103
76MAPK130.52947583
77MELK0.51268342
78YES10.51067711
79RPS6KA20.50027573
80RPS6KA50.49326226
81MAP4K20.48473308
82BTK0.47779940
83STK160.47648128
84MAP2K20.47147036
85LMTK20.45865124
86LATS20.45586558
87PRKCG0.44403524
88ROCK10.43855239
89MAP3K40.41123590
90ATM0.40858781
91CDK50.40608974
92RIPK40.40607219
93PRKG20.40530025
94MAP3K60.40481935
95MOS0.40218771
96MAP3K90.39694454
97FGR0.39245129
98GRK50.38297850
99EGFR0.38123570
100RPS6KB10.37477331
101TRPM70.37417133
102ITK0.36553718
103ADRBK10.36272910
104CASK0.35317045
105NEK90.34791106
106CHEK20.34664692
107PRKCQ0.34200258
108CDK140.33731546
109TNIK0.32988162
110MAP3K50.32285738
111RET0.32012993
112NLK0.31893977
113AURKA0.31481152
114OXSR10.30858681
115PDK10.30629966
116PAK30.30404006
117MAP3K10.30237146
118PRKCZ0.30186592
119AKT30.28649054
120EIF2AK30.28635148
121MAP3K130.28349721
122CSNK1A10.28039871
123RPS6KB20.27317270
124LRRK20.26735511
125CDC70.26654326
126CLK10.26251897
127MAPK70.26185430
128ADRBK20.25355416
129MAP2K70.25174359
130DAPK30.24896878
131PRKACG0.24439046
132PASK0.24302127
133DYRK1B0.23748936
134PDPK10.23541272
135ABL10.23454051
136MAPKAPK30.23297150
137SGK30.22892989
138MAPK40.22728311
139RPS6KA30.22318455
140PLK40.22160219
141MET0.21682293
142CAMK10.21194233
143CAMK2A0.20812458
144AKT20.19630775
145NEK60.19462291
146MST1R0.19408919
147PRKG10.19096017
148PRKAA10.18925367
149RPS6KL10.18885001
150RPS6KC10.18885001
151PAK10.18717456
152GSK3A0.18558467
153NTRK30.18167528
154SGK10.18026112
155LYN0.17730651
156MAPKAPK20.17568539
157PRKAA20.17466177
158PRKACA0.17332397
159MAP3K20.16947267
160GRK60.16264041
161CDK80.15015769
162EPHA40.14934427
163CSNK1D0.14856546
164MAPK10.13333658
165STK110.12456410

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.95145506
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051306.09662603
3Vitamin B6 metabolism_Homo sapiens_hsa007505.16656327
4Gap junction_Homo sapiens_hsa045404.45369206
5Nitrogen metabolism_Homo sapiens_hsa009103.68925572
6Hedgehog signaling pathway_Homo sapiens_hsa043403.22871224
7Huntingtons disease_Homo sapiens_hsa050163.06012847
8Pyruvate metabolism_Homo sapiens_hsa006202.33147221
9Dorso-ventral axis formation_Homo sapiens_hsa043202.32615351
10Butanoate metabolism_Homo sapiens_hsa006502.26709555
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.15158305
12Apoptosis_Homo sapiens_hsa042102.10315527
13Antigen processing and presentation_Homo sapiens_hsa046122.05610538
14Chemical carcinogenesis_Homo sapiens_hsa052042.01534242
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95718531
16Alcoholism_Homo sapiens_hsa050341.94112158
17Fanconi anemia pathway_Homo sapiens_hsa034601.85886434
18Arginine biosynthesis_Homo sapiens_hsa002201.81817490
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.78143227
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.70765353
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60239162
22Basal transcription factors_Homo sapiens_hsa030221.57314375
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56324364
24Fatty acid biosynthesis_Homo sapiens_hsa000611.52153665
25Olfactory transduction_Homo sapiens_hsa047401.44186921
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41891307
27Propanoate metabolism_Homo sapiens_hsa006401.36602988
28Purine metabolism_Homo sapiens_hsa002301.31844925
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31628846
30Glucagon signaling pathway_Homo sapiens_hsa049221.29674080
31Linoleic acid metabolism_Homo sapiens_hsa005911.27564046
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26403278
33beta-Alanine metabolism_Homo sapiens_hsa004101.21652586
34Pentose phosphate pathway_Homo sapiens_hsa000301.21114185
35Phenylalanine metabolism_Homo sapiens_hsa003601.20961873
36Amphetamine addiction_Homo sapiens_hsa050311.19166764
37Tryptophan metabolism_Homo sapiens_hsa003801.16456862
38Renin secretion_Homo sapiens_hsa049241.15071431
39PPAR signaling pathway_Homo sapiens_hsa033201.09727695
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09555125
41Circadian rhythm_Homo sapiens_hsa047101.07011310
42Glycerolipid metabolism_Homo sapiens_hsa005611.05189413
43Ether lipid metabolism_Homo sapiens_hsa005651.04042597
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03307024
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00614053
46Retinol metabolism_Homo sapiens_hsa008300.98825977
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98102641
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98014995
49Arachidonic acid metabolism_Homo sapiens_hsa005900.93215708
50Caffeine metabolism_Homo sapiens_hsa002320.92900114
51Oxytocin signaling pathway_Homo sapiens_hsa049210.91104848
52Glutathione metabolism_Homo sapiens_hsa004800.90274571
53Calcium signaling pathway_Homo sapiens_hsa040200.89513842
54Tyrosine metabolism_Homo sapiens_hsa003500.87545133
55Ovarian steroidogenesis_Homo sapiens_hsa049130.87312646
56Graft-versus-host disease_Homo sapiens_hsa053320.86360354
57Estrogen signaling pathway_Homo sapiens_hsa049150.81791699
58Taste transduction_Homo sapiens_hsa047420.79563705
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76139755
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74882223
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71265451
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.70135425
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69913242
64Oocyte meiosis_Homo sapiens_hsa041140.69899979
65Fatty acid degradation_Homo sapiens_hsa000710.69203897
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68927614
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66175208
68cAMP signaling pathway_Homo sapiens_hsa040240.65288291
69Staphylococcus aureus infection_Homo sapiens_hsa051500.65043243
70Systemic lupus erythematosus_Homo sapiens_hsa053220.64790051
71B cell receptor signaling pathway_Homo sapiens_hsa046620.63627842
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62464979
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62254367
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62156113
75Asthma_Homo sapiens_hsa053100.60231926
76Homologous recombination_Homo sapiens_hsa034400.59705650
77Other glycan degradation_Homo sapiens_hsa005110.58874313
78Nucleotide excision repair_Homo sapiens_hsa034200.58680618
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57629323
80Allograft rejection_Homo sapiens_hsa053300.57425377
81Cardiac muscle contraction_Homo sapiens_hsa042600.57413894
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.57332125
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56654403
84Pyrimidine metabolism_Homo sapiens_hsa002400.55844404
85Collecting duct acid secretion_Homo sapiens_hsa049660.55703706
86ABC transporters_Homo sapiens_hsa020100.55187124
87Hematopoietic cell lineage_Homo sapiens_hsa046400.54441327
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.53960050
89Mineral absorption_Homo sapiens_hsa049780.53541147
90Circadian entrainment_Homo sapiens_hsa047130.53537240
91Fructose and mannose metabolism_Homo sapiens_hsa000510.53331153
92Phagosome_Homo sapiens_hsa041450.52527491
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51049047
94Cocaine addiction_Homo sapiens_hsa050300.49964630
95Peroxisome_Homo sapiens_hsa041460.49579854
96GABAergic synapse_Homo sapiens_hsa047270.49430033
97Osteoclast differentiation_Homo sapiens_hsa043800.49117386
98Gastric acid secretion_Homo sapiens_hsa049710.49091062
99Thyroid hormone synthesis_Homo sapiens_hsa049180.48433491
100TGF-beta signaling pathway_Homo sapiens_hsa043500.48325566
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47803316
102Salmonella infection_Homo sapiens_hsa051320.46384289
103Salivary secretion_Homo sapiens_hsa049700.45706540
104Sphingolipid metabolism_Homo sapiens_hsa006000.44980831
105Regulation of autophagy_Homo sapiens_hsa041400.43700696
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.43120831
107Synaptic vesicle cycle_Homo sapiens_hsa047210.43042935
108Nicotine addiction_Homo sapiens_hsa050330.42143804
109Malaria_Homo sapiens_hsa051440.41151836
110Rheumatoid arthritis_Homo sapiens_hsa053230.41110354
111Insulin secretion_Homo sapiens_hsa049110.40986214
112Glutamatergic synapse_Homo sapiens_hsa047240.40983258
113Choline metabolism in cancer_Homo sapiens_hsa052310.40820135
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40000337
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39274146
116Morphine addiction_Homo sapiens_hsa050320.38735666
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.38613877
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38383352
119Wnt signaling pathway_Homo sapiens_hsa043100.38047589
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.37497981
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36188157
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35910127
123Vitamin digestion and absorption_Homo sapiens_hsa049770.34509004
124Serotonergic synapse_Homo sapiens_hsa047260.33893808
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33366957
126Leishmaniasis_Homo sapiens_hsa051400.32999598
127Histidine metabolism_Homo sapiens_hsa003400.32403098
128mRNA surveillance pathway_Homo sapiens_hsa030150.31999123
129Alzheimers disease_Homo sapiens_hsa050100.31980208
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31373497
131Measles_Homo sapiens_hsa051620.31112564
132Inositol phosphate metabolism_Homo sapiens_hsa005620.30488421
133Viral myocarditis_Homo sapiens_hsa054160.29373799
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28767284
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28733728
136Autoimmune thyroid disease_Homo sapiens_hsa053200.28379434
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26874299
138Metabolic pathways_Homo sapiens_hsa011000.26583206
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25921660
140Selenocompound metabolism_Homo sapiens_hsa004500.24550829
141MAPK signaling pathway_Homo sapiens_hsa040100.24230156
142Dopaminergic synapse_Homo sapiens_hsa047280.23703758
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23428003
144Tight junction_Homo sapiens_hsa045300.21839552
145RNA degradation_Homo sapiens_hsa030180.21171788
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20281793

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