ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	spermatid development (GO:0007286)	9.65541637
2	axonemal dynein complex assembly (GO:0070286)	9.62995481
3	reproduction (GO:0000003)	9.57433053
4	motile cilium assembly (GO:0044458)	9.23371157
5	cilium or flagellum-dependent cell motility (GO:0001539)	8.15028300
6	cilium movement (GO:0003341)	7.99444812
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.57386753
8	regulation of cilium movement (GO:0003352)	7.55015346
9	single fertilization (GO:0007338)	7.33568579
10	synaptonemal complex organization (GO:0070193)	7.20406779
11	synaptonemal complex assembly (GO:0007130)	7.19107432
12	male meiosis (GO:0007140)	6.99751273
13	sperm capacitation (GO:0048240)	6.77474298
14	piRNA metabolic process (GO:0034587)	6.63345730
15	spermatogenesis (GO:0007283)	6.62849596
16	male gamete generation (GO:0048232)	6.60392999
17	negative regulation of inclusion body assembly (GO:0090084)	6.54037884
18	organic cation transport (GO:0015695)	6.39311817
19	microtubule depolymerization (GO:0007019)	6.26426437
20	fertilization (GO:0009566)	6.22301298
21	gamete generation (GO:0007276)	6.06515388
22	spermatid nucleus differentiation (GO:0007289)	5.84720543
23	regulation of inclusion body assembly (GO:0090083)	5.65366737
24	calcium ion-dependent exocytosis (GO:0017156)	5.44378146
25	germ cell development (GO:0007281)	5.36768185
26	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.35971781
27	chromosome condensation (GO:0030261)	5.10880219
28	single strand break repair (GO:0000012)	5.08246051
29	cell recognition (GO:0008037)	5.06827671
30	glycerol ether metabolic process (GO:0006662)	5.02593757
31	sexual reproduction (GO:0019953)	5.00502582
32	chromosome organization involved in meiosis (GO:0070192)	4.91347835
33	DNA packaging (GO:0006323)	4.83479969
34	ventricular system development (GO:0021591)	4.82393634
35	microtubule severing (GO:0051013)	4.80169216
36	multicellular organismal reproductive process (GO:0048609)	4.74993133
37	sequestering of actin monomers (GO:0042989)	4.72921748
38	seminiferous tubule development (GO:0072520)	4.71092489
39	ether metabolic process (GO:0018904)	4.64161735
40	DNA methylation involved in gamete generation (GO:0043046)	4.50093515
41	male meiosis I (GO:0007141)	4.41780018
42	regulation of microtubule-based movement (GO:0060632)	4.40522899
43	protein K11-linked deubiquitination (GO:0035871)	4.25491337
44	meiotic nuclear division (GO:0007126)	4.17029889
45	chaperone-mediated protein complex assembly (GO:0051131)	4.09571748
46	left/right pattern formation (GO:0060972)	3.98587232
47	multicellular organismal development (GO:0007275)	3.90545905
48	genitalia morphogenesis (GO:0035112)	3.80948261
49	monoubiquitinated protein deubiquitination (GO:0035520)	3.76249901
50	meiosis I (GO:0007127)	3.49081351
51	GTP biosynthetic process (GO:0006183)	3.31380468
52	microtubule polymerization or depolymerization (GO:0031109)	3.23468949
53	glycolytic process (GO:0006096)	3.18383354
54	protein polyglutamylation (GO:0018095)	3.16875372
55	meiotic cell cycle (GO:0051321)	3.16583898
56	regulation of spindle checkpoint (GO:0090231)	3.16177922
57	nucleoside diphosphate phosphorylation (GO:0006165)	3.15515052
58	polyol catabolic process (GO:0046174)	3.07088601
59	protein refolding (GO:0042026)	3.06369344
60	positive regulation of macrophage activation (GO:0043032)	3.05753863
61	carnitine transport (GO:0015879)	3.03048940
62	amino-acid betaine transport (GO:0015838)	3.03048940
63	alditol metabolic process (GO:0019400)	3.02280656
64	nucleus organization (GO:0006997)	3.02118750
65	lactate metabolic process (GO:0006089)	3.01659888
66	interferon-gamma secretion (GO:0072643)	3.00505785
67	protein localization to cilium (GO:0061512)	2.99347530
68	UTP biosynthetic process (GO:0006228)	2.95654257
69	mitotic sister chromatid cohesion (GO:0007064)	2.95256454
70	chromatin silencing (GO:0006342)	2.84347911
71	protein-DNA complex disassembly (GO:0032986)	2.84165223
72	nucleosome disassembly (GO:0006337)	2.84165223
73	carnitine transmembrane transport (GO:1902603)	2.82137495
74	synapsis (GO:0007129)	2.81283008
75	cilium organization (GO:0044782)	2.81059869
76	intraciliary transport (GO:0042073)	2.75293395
77	meiotic cell cycle process (GO:1903046)	2.72777813
78	cellular component assembly involved in morphogenesis (GO:0010927)	2.72611412
79	UTP metabolic process (GO:0046051)	2.69071775
80	cilium morphogenesis (GO:0060271)	2.68736916
81	cilium assembly (GO:0042384)	2.68676100
82	microtubule-based movement (GO:0007018)	2.61995283
83	axoneme assembly (GO:0035082)	2.60280079
84	RNA localization (GO:0006403)	2.59911716
85	glycerol metabolic process (GO:0006071)	2.59197175
86	negative regulation of organelle assembly (GO:1902116)	2.53122437
87	regulation of cilium assembly (GO:1902017)	2.50204191
88	centriole assembly (GO:0098534)	2.47643776
89	cell wall macromolecule metabolic process (GO:0044036)	14.5178024
90	cell wall macromolecule catabolic process (GO:0016998)	14.5178024
91	sperm motility (GO:0030317)	13.7127315
92	fusion of sperm to egg plasma membrane (GO:0007342)	13.6325971
93	acrosome assembly (GO:0001675)	12.4672860
94	acrosome reaction (GO:0007340)	11.7815991
95	sperm-egg recognition (GO:0035036)	11.7416782
96	binding of sperm to zona pellucida (GO:0007339)	10.9109671
97	multicellular organism reproduction (GO:0032504)	10.8798461
98	cell-cell recognition (GO:0009988)	10.5015861
99	plasma membrane fusion (GO:0045026)	10.3734352
100	epithelial cilium movement (GO:0003351)	10.0544820

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.02220151
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.00336509
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.28578191
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.04156787
5	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.00486473
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.82612300
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.44412076
8	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.27145305
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27062548
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18724721
11	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.08559460
12	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.04853318
13	VDR_22108803_ChIP-Seq_LS180_Human	2.02328960
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	10.1896983
15	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.95260276
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.85185658
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.85009463
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84458791
19	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.75252578
20	STAT1_17558387_ChIP-Seq_HELA_Human	1.71224224
21	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.69220378
22	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.67264958
23	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.66228012
24	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.61229771
25	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61075282
26	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.59257658
27	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.57462014
28	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.56911543
29	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.54576186
30	KDM2B_26808549_Chip-Seq_REH_Human	1.49212963
31	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.48848809
32	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.48163521
33	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.37530679
34	P53_21459846_ChIP-Seq_SAOS-2_Human	1.37258722
35	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.36173141
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35514934
37	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.32665586
38	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.31058082
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.30126984
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30126984
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29812799
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29724872
43	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.25762328
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24928726
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24452850
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.22247171
47	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20868461
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20121298
49	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.18560184
50	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15977351
51	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.15646273
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15261901
53	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.13860733
54	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13572062
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12116638
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11645427
57	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.11284275
58	GF1_26923725_Chip-Seq_HPCs_Mouse	1.11067263
59	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10380043
60	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.09179559
61	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09160221
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08291925
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08291925
64	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.08173848
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07036961
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06694057
67	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06334608
68	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.06133263
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05853159
70	ERG_20517297_ChIP-Seq_VCAP_Human	1.04066275
71	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03748135
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03169785
73	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.02621873
74	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.01141103
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00661281
76	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.99327178
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98883294
78	SOX9_26525672_Chip-Seq_HEART_Mouse	0.98543322
79	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.98510097
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.98147706
81	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.98015685
82	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98002187
83	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97800958
84	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.96183249
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96169536
86	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.95948962
87	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.95034895
88	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.94648343
89	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.93939673
90	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.93302886
91	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.92383106
92	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.91542929
93	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.91447509
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.89987985
95	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.87901188
96	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.86126516
97	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.86074311
98	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.85923124
99	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83791578
100	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.83769528

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.07780456
2	MP0001929_abnormal_gametogenesis	5.61675891
3	MP0008877_abnormal_DNA_methylation	3.92541428
4	MP0002210_abnormal_sex_determination	3.46213683
5	MP0002161_abnormal_fertility/fecundity	3.29796626
6	MP0001145_abnormal_male_reproductive	2.96932470
7	MP0000653_abnormal_sex_gland	2.55744446
8	MP0005670_abnormal_white_adipose	2.47596711
9	MP0002653_abnormal_ependyma_morphology	2.21235292
10	MP0005410_abnormal_fertilization	16.3979915
11	MP0002160_abnormal_reproductive_system	1.89399988
12	MP0004233_abnormal_muscle_weight	1.56789738
13	MP0003646_muscle_fatigue	1.39560300
14	MP0001765_abnormal_ion_homeostasis	1.22178606
15	MP0002282_abnormal_trachea_morphology	1.21820033
16	MP0005623_abnormal_meninges_morphology	1.15037258
17	MP0008058_abnormal_DNA_repair	1.10078030
18	MP0005647_abnormal_sex_gland	1.00642137
19	MP0005389_reproductive_system_phenotype	0.94254781
20	MP0003011_delayed_dark_adaptation	0.92145250
21	MP0002234_abnormal_pharynx_morphology	0.84099089
22	MP0001984_abnormal_olfaction	0.79170251
23	MP0005636_abnormal_mineral_homeostasis	0.73956549
24	MP0003115_abnormal_respiratory_system	0.72903791
25	MP0008995_early_reproductive_senescence	0.71964076
26	MP0001293_anophthalmia	0.59976642
27	MP0004036_abnormal_muscle_relaxation	0.56750626
28	MP0001324_abnormal_eye_pigmentation	0.56727895
29	MP0004043_abnormal_pH_regulation	0.55546930
30	MP0010094_abnormal_chromosome_stability	0.55461406
31	MP0000534_abnormal_ureter_morphology	0.55357252
32	MP0005253_abnormal_eye_physiology	0.55160001
33	MP0005377_hearing/vestibular/ear_phenot	0.54308791
34	MP0003878_abnormal_ear_physiology	0.54308791
35	MP0006036_abnormal_mitochondrial_physio	0.52361141
36	MP0002736_abnormal_nociception_after	0.50632172
37	MP0004019_abnormal_vitamin_homeostasis	0.50387949
38	MP0008057_abnormal_DNA_replication	0.49091994
39	MP0003942_abnormal_urinary_system	0.48993189
40	MP0005666_abnormal_adipose_tissue	0.48462600
41	MP0000358_abnormal_cell_content/	0.46429981
42	MP0009046_muscle_twitch	0.45924502
43	MP0002269_muscular_atrophy	0.45023567
44	MP0005551_abnormal_eye_electrophysiolog	0.44719390
45	MP0003699_abnormal_female_reproductive	0.43453523
46	MP0005391_vision/eye_phenotype	0.43318284
47	MP0002102_abnormal_ear_morphology	0.41467165
48	MP0004133_heterotaxia	0.41334996
49	MP0004145_abnormal_muscle_electrophysio	0.40316982
50	MP0006072_abnormal_retinal_apoptosis	0.39699067
51	MP0003111_abnormal_nucleus_morphology	0.39618575
52	MP0001764_abnormal_homeostasis	0.39445606
53	MP0002928_abnormal_bile_duct	0.35938462
54	MP0009250_abnormal_appendicular_skeleto	0.35880614
55	MP0003861_abnormal_nervous_system	0.35600762
56	MP0008007_abnormal_cellular_replicative	0.35580110
57	MP0001730_embryonic_growth_arrest	0.33669831
58	MP0003950_abnormal_plasma_membrane	0.33220159
59	MP0001119_abnormal_female_reproductive	0.31656203
60	MP0000049_abnormal_middle_ear	0.30698151
61	MP0003329_amyloid_beta_deposits	0.29373111
62	MP0003315_abnormal_perineum_morphology	0.28449062
63	MP0003786_premature_aging	0.28240677
64	MP0002152_abnormal_brain_morphology	0.28137380
65	MP0001968_abnormal_touch/_nociception	0.26861743
66	MP0002092_abnormal_eye_morphology	0.26124858
67	MP0002084_abnormal_developmental_patter	0.26121219
68	MP0002169_no_abnormal_phenotype	0.25185640
69	MP0001849_ear_inflammation	0.24978543
70	MP0003385_abnormal_body_wall	0.24845974
71	MP0002873_normal_phenotype	0.24796030
72	MP0009672_abnormal_birth_weight	0.24575069
73	MP0006035_abnormal_mitochondrial_morpho	0.24245653
74	MP0004811_abnormal_neuron_physiology	0.23698211
75	MP0009115_abnormal_fat_cell	0.23478290
76	MP0001270_distended_abdomen	0.23219849
77	MP0001348_abnormal_lacrimal_gland	0.23083161
78	MP0005195_abnormal_posterior_eye	0.22776592
79	MP0008961_abnormal_basal_metabolism	0.22687300
80	MP0005257_abnormal_intraocular_pressure	0.22528791
81	MP0000313_abnormal_cell_death	0.22354538
82	MP0005397_hematopoietic_system_phenotyp	0.22031389
83	MP0001545_abnormal_hematopoietic_system	0.22031389
84	MP0009278_abnormal_bone_marrow	0.21897896
85	MP0003948_abnormal_gas_homeostasis	0.21841590
86	MP0001697_abnormal_embryo_size	0.19967996
87	MP0002932_abnormal_joint_morphology	0.19079687
88	MP0010307_abnormal_tumor_latency	0.18356432
89	MP0001672_abnormal_embryogenesis/_devel	0.18350226
90	MP0005380_embryogenesis_phenotype	0.18350226
91	MP0001727_abnormal_embryo_implantation	0.17839149
92	MP0002085_abnormal_embryonic_tissue	0.17748565
93	MP0002971_abnormal_brown_adipose	0.17662185
94	MP0002109_abnormal_limb_morphology	0.17520758
95	MP0000751_myopathy	0.17496644
96	MP0003959_abnormal_lean_body	0.17345253
97	MP0005360_urolithiasis	0.16654808
98	MP0004742_abnormal_vestibular_system	0.16605220
99	MP0003936_abnormal_reproductive_system	0.16534455
100	MP0003077_abnormal_cell_cycle	0.16350397

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.56444116
2	Abnormal respiratory epithelium morphology (HP:0012253)	9.48024108
3	Abnormal respiratory motile cilium morphology (HP:0005938)	9.48024108
4	Chronic bronchitis (HP:0004469)	8.03064882
5	Abnormal ciliary motility (HP:0012262)	7.66859528
6	Rhinitis (HP:0012384)	7.54049999
7	Infertility (HP:0000789)	6.68763715
8	Nasal polyposis (HP:0100582)	6.22337906
9	Abnormality of the nasal mucosa (HP:0000433)	5.10914355
10	Bronchitis (HP:0012387)	4.47595998
11	Bronchiectasis (HP:0002110)	4.35155848
12	Nephronophthisis (HP:0000090)	4.32664071
13	Male infertility (HP:0003251)	4.17358501
14	Recurrent sinusitis (HP:0011108)	3.47833405
15	Abnormality of the renal medulla (HP:0100957)	3.32253257
16	Abnormal spermatogenesis (HP:0008669)	3.19483809
17	Recurrent otitis media (HP:0000403)	3.14992900
18	Tubulointerstitial nephritis (HP:0001970)	2.86696280
19	Tubular atrophy (HP:0000092)	2.73365572
20	Molar tooth sign on MRI (HP:0002419)	2.71954482
21	Abnormality of midbrain morphology (HP:0002418)	2.71954482
22	Medial flaring of the eyebrow (HP:0010747)	2.59295265
23	Tubulointerstitial abnormality (HP:0001969)	2.42350279
24	Impulsivity (HP:0100710)	2.15199698
25	Recurrent bronchitis (HP:0002837)	2.10616741
26	Cholecystitis (HP:0001082)	2.08358240
27	Abnormal gallbladder physiology (HP:0012438)	2.08358240
28	Gonadotropin excess (HP:0000837)	2.06626396
29	Absent/shortened dynein arms (HP:0200106)	13.7724532
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.7724532
31	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.1453372
32	Azoospermia (HP:0000027)	1.99370277
33	Polydipsia (HP:0001959)	1.96721029
34	Abnormal drinking behavior (HP:0030082)	1.96721029
35	Stage 5 chronic kidney disease (HP:0003774)	1.95036854
36	Abnormality of renal excretion (HP:0011036)	1.94093288
37	Dyschromatopsia (HP:0007641)	1.92702111
38	Tubulointerstitial fibrosis (HP:0005576)	1.92008949
39	Postaxial foot polydactyly (HP:0001830)	1.80447209
40	Double outlet right ventricle (HP:0001719)	1.79165640
41	Congenital malformation of the right heart (HP:0011723)	1.79165640
42	Congenital hepatic fibrosis (HP:0002612)	1.78773048
43	Abnormality of the renal cortex (HP:0011035)	1.75921236
44	Fibular hypoplasia (HP:0003038)	1.63705434
45	Abnormality of the dental root (HP:0006486)	1.62964176
46	Taurodontia (HP:0000679)	1.62964176
47	Abnormality of permanent molar morphology (HP:0011071)	1.62964176
48	Decreased central vision (HP:0007663)	1.61308782
49	Oculomotor apraxia (HP:0000657)	1.58735162
50	Abnormal urine output (HP:0012590)	1.56916549
51	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.55798918
52	Choroideremia (HP:0001139)	1.53616274
53	Asymmetric septal hypertrophy (HP:0001670)	1.51189952
54	Abnormality of the dental pulp (HP:0006479)	1.50372437
55	Abnormality of molar morphology (HP:0011070)	1.48802526
56	Abnormality of molar (HP:0011077)	1.48802526
57	Renal dysplasia (HP:0000110)	1.48741412
58	Aplasia/Hypoplasia of the lens (HP:0008063)	1.48129058
59	Hemorrhage of the eye (HP:0011885)	1.46293938
60	Postaxial hand polydactyly (HP:0001162)	1.43591162
61	Short ribs (HP:0000773)	1.43494996
62	Facial cleft (HP:0002006)	1.43267351
63	Spastic tetraparesis (HP:0001285)	1.42403380
64	Cystic liver disease (HP:0006706)	1.41960670
65	Bile duct proliferation (HP:0001408)	1.40655033
66	Abnormal biliary tract physiology (HP:0012439)	1.40655033
67	Polyuria (HP:0000103)	1.38016396
68	Heterotopia (HP:0002282)	1.36501543
69	Constricted visual fields (HP:0001133)	1.36340706
70	Abnormality of dentin (HP:0010299)	1.35594480
71	Exercise-induced myalgia (HP:0003738)	1.31668575
72	Abnormality of the lower motor neuron (HP:0002366)	1.31539284
73	Vascular calcification (HP:0004934)	1.30868704
74	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.30761667
75	Congenital primary aphakia (HP:0007707)	1.28652003
76	Gait imbalance (HP:0002141)	1.28501753
77	Chronic sinusitis (HP:0011109)	1.27786811
78	Bundle branch block (HP:0011710)	1.27151494
79	Pancreatic fibrosis (HP:0100732)	1.25914863
80	Bell-shaped thorax (HP:0001591)	1.25096077
81	Myoglobinuria (HP:0002913)	1.24289661
82	Supernumerary spleens (HP:0009799)	1.21102530
83	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.20406915
84	Absent epiphyses (HP:0010577)	1.20406915
85	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.20265733
86	Broad distal phalanx of finger (HP:0009836)	1.19885446
87	True hermaphroditism (HP:0010459)	1.19680657
88	Cerebellar dysplasia (HP:0007033)	1.18225306
89	Nephropathy (HP:0000112)	1.17041194
90	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.16550378
91	Cardiovascular calcification (HP:0011915)	1.15702735
92	Sensory axonal neuropathy (HP:0003390)	1.13853523
93	Abnormality of saccadic eye movements (HP:0000570)	1.13454129
94	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.11294900
95	Breast carcinoma (HP:0003002)	1.11048141
96	Pancreatic cysts (HP:0001737)	1.10689123
97	Nephrogenic diabetes insipidus (HP:0009806)	1.10317851
98	Abnormality of renal resorption (HP:0011038)	1.10303750
99	Vaginal atresia (HP:0000148)	1.10258856
100	Neurofibrillary tangles (HP:0002185)	1.09848767

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.95605225
2	PDK4	8.95605225
3	PDK2	5.78690404
4	TESK1	5.63949167
5	PRKD3	3.91088637
6	ICK	3.77220557
7	WNK4	2.07315703
8	PTK2B	1.99594397
9	STK39	1.86664987
10	STK38	1.63470327
11	NEK2	1.59789223
12	PNCK	1.40391357
13	DYRK1B	1.31910768
14	TLK1	1.21096941
15	PDK1	1.13537595
16	IRAK1	0.93489432
17	MAPK15	0.88093605
18	DYRK3	0.86434189
19	PASK	0.77322594
20	WNK1	0.72456832
21	TESK2	0.70883707
22	PINK1	0.70368122
23	TYRO3	0.68709003
24	PDPK1	0.62971538
25	CHEK2	0.59050003
26	IRAK2	0.57134927
27	STK38L	0.55913619
28	MAP3K10	0.54886067
29	LMTK2	0.52676883
30	CCNB1	0.51338383
31	EEF2K	0.51257346
32	TTK	0.50576341
33	MAP2K6	0.45460949
34	STK3	0.45361426
35	PAK1	0.37641027
36	WNK3	0.37272393
37	CHEK1	0.34565595
38	RIPK4	0.34226423
39	PRKCG	0.32300360
40	MUSK	0.31169043
41	NTRK2	0.28011822
42	ATM	0.24491533
43	PAK2	0.24348617
44	CDC7	0.23756996
45	ATR	0.23483881
46	PLK4	0.23024159
47	CAMK1G	0.20065302
48	MTOR	0.18823075
49	PLK1	0.17812967
50	PRKCZ	0.16489625
51	BRAF	0.16102468
52	MARK3	0.15555859
53	PRKAA1	0.14715556
54	MARK2	0.14326856
55	CDK15	0.13459579
56	CAMKK1	0.13263061
57	PKN1	0.13100735
58	CDK11A	0.11930125
59	RPS6KB1	0.11923524
60	WEE1	0.11705406
61	CDK18	0.11029945
62	SRPK1	0.10034289
63	CSNK2A1	0.09964797
64	INSRR	0.09677459
65	PRKCQ	0.09455028
66	NEK6	0.09184912
67	CDK14	0.09140485
68	CLK1	0.09057321
69	MAPKAPK5	0.08812790
70	BRSK2	0.07465330
71	PRKG2	0.06643500
72	RPS6KA1	0.06174954
73	PAK4	0.05774939
74	PRKACG	0.04951305
75	CDK2	0.04849962
76	AURKA	0.04230391
77	PRKG1	0.03730393
78	PIM1	0.03397655
79	CSNK2A2	0.02933291
80	CDK1	0.02780956
81	EPHB2	0.02716062
82	PRKCD	0.02414716
83	GSK3B	0.02309313
84	BRSK1	0.02221638
85	STK10	0.02081543
86	DAPK3	0.01725400
87	MAPK8	0.00396028
88	TRIB3	0.00379818
89	CDK4	-0.0342184
90	PRKACA	-0.0327306
91	OXSR1	-0.0324779
92	EIF2AK1	-0.0271704
93	PRKDC	-0.0236327
94	GSK3A	-0.0189646
95	CSNK1E	-0.0172843
96	CAMK2A	-0.0108622
97	PRKCB	-0.0087570
98	STK11	-0.0063610
99	PRKCA	-0.0063401
100	CSNK1D	-0.0012647

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.59773200
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.26159471
3	Pyruvate metabolism_Homo sapiens_hsa00620	3.97836177
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.82091806
5	Propanoate metabolism_Homo sapiens_hsa00640	3.11132053
6	Glucagon signaling pathway_Homo sapiens_hsa04922	2.76647061
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.72183796
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.67146465
9	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.53346083
10	Basal transcription factors_Homo sapiens_hsa03022	2.46254547
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.44366931
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.13267933
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.00179215
14	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.95817501
15	Oocyte meiosis_Homo sapiens_hsa04114	1.85931625
16	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.82195026
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.77454611
18	Glycerolipid metabolism_Homo sapiens_hsa00561	1.76348636
19	Pentose phosphate pathway_Homo sapiens_hsa00030	1.75039627
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71928319
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.66001342
22	Carbon metabolism_Homo sapiens_hsa01200	1.53412420
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49902039
24	Amphetamine addiction_Homo sapiens_hsa05031	1.45745294
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45516618
26	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.45112639
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.39205927
28	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.35073803
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34948663
30	Mineral absorption_Homo sapiens_hsa04978	1.32330983
31	Huntingtons disease_Homo sapiens_hsa05016	1.32019867
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.29708872
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.29088016
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.21932498
35	Fatty acid degradation_Homo sapiens_hsa00071	1.19771174
36	Glutathione metabolism_Homo sapiens_hsa00480	1.18032960
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.17453458
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.15405476
39	mRNA surveillance pathway_Homo sapiens_hsa03015	1.15332242
40	Purine metabolism_Homo sapiens_hsa00230	1.11606920
41	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.09884466
42	Renin secretion_Homo sapiens_hsa04924	1.06100373
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.05325014
44	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02123631
45	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.95626919
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.95047429
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.94151833
48	RNA transport_Homo sapiens_hsa03013	0.90824434
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90312150
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83728878
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.83457543
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75904920
53	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.74358177
54	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72096785
55	Long-term potentiation_Homo sapiens_hsa04720	0.71726012
56	Insulin secretion_Homo sapiens_hsa04911	0.70520355
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69439940
58	Bile secretion_Homo sapiens_hsa04976	0.67147790
59	Alcoholism_Homo sapiens_hsa05034	0.66838965
60	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65585562
61	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62813135
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.62094399
63	Estrogen signaling pathway_Homo sapiens_hsa04915	0.59469999
64	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.57131835
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53432554
66	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.51049709
67	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.49697638
68	Sulfur metabolism_Homo sapiens_hsa00920	0.49405228
69	Metabolic pathways_Homo sapiens_hsa01100	0.46962204
70	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.42613892
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.42532042
72	Legionellosis_Homo sapiens_hsa05134	0.41972122
73	VEGF signaling pathway_Homo sapiens_hsa04370	0.41151107
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.40816599
75	Basal cell carcinoma_Homo sapiens_hsa05217	0.39244345
76	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39174381
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.37916039
78	Pancreatic secretion_Homo sapiens_hsa04972	0.35414650
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.34539269
80	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33554302
81	Renin-angiotensin system_Homo sapiens_hsa04614	0.32855412
82	DNA replication_Homo sapiens_hsa03030	0.32510216
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31707843
84	Endocytosis_Homo sapiens_hsa04144	0.29006733
85	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.28521558
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28201448
87	ABC transporters_Homo sapiens_hsa02010	0.26521697
88	Salivary secretion_Homo sapiens_hsa04970	0.24189997
89	Oxidative phosphorylation_Homo sapiens_hsa00190	0.23879836
90	Sulfur relay system_Homo sapiens_hsa04122	0.23878418
91	Gastric acid secretion_Homo sapiens_hsa04971	0.23178099
92	Cell cycle_Homo sapiens_hsa04110	0.18450129
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.17534938
94	Parkinsons disease_Homo sapiens_hsa05012	0.17514447
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.17468364
96	Viral carcinogenesis_Homo sapiens_hsa05203	0.16361578
97	Alzheimers disease_Homo sapiens_hsa05010	0.15570630
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.15203179
99	Circadian entrainment_Homo sapiens_hsa04713	0.13749081
100	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.11730574

CCDC182

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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