CCDC183

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.72330392
2spermatid development (GO:0007286)9.52282037
3motile cilium assembly (GO:0044458)9.52205329
4regulation of cilium movement (GO:0003352)9.13841088
5cilium movement (GO:0003341)8.41574261
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.87625170
7single fertilization (GO:0007338)7.65096351
8piRNA metabolic process (GO:0034587)7.43292664
9sperm capacitation (GO:0048240)7.36626512
10male meiosis (GO:0007140)7.30552526
11plasma lipoprotein particle assembly (GO:0034377)7.26855288
12very-low-density lipoprotein particle assembly (GO:0034379)7.21646623
13synaptonemal complex organization (GO:0070193)6.97845361
14synaptonemal complex assembly (GO:0007130)6.72677841
15protein-lipid complex assembly (GO:0065005)6.52532827
16fertilization (GO:0009566)6.35819279
17microtubule depolymerization (GO:0007019)6.35295349
18spermatogenesis (GO:0007283)6.32777415
19male gamete generation (GO:0048232)6.30226065
20negative regulation of inclusion body assembly (GO:0090084)6.25499179
21negative regulation of fibrinolysis (GO:0051918)6.15953089
22peptidyl-glutamic acid carboxylation (GO:0017187)6.14463732
23protein carboxylation (GO:0018214)6.14463732
24organic cation transport (GO:0015695)6.05427503
25gamete generation (GO:0007276)5.79271779
26calcium ion-dependent exocytosis (GO:0017156)5.72501838
27lung epithelium development (GO:0060428)5.55598796
28intestinal cholesterol absorption (GO:0030299)5.43209387
29ventricular system development (GO:0021591)5.42638948
30regulation of microtubule-based movement (GO:0060632)5.40981022
31regulation of inclusion body assembly (GO:0090083)5.36917618
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.33202634
33regulation of cholesterol esterification (GO:0010872)5.31469979
34germ cell development (GO:0007281)5.30225368
35low-density lipoprotein particle remodeling (GO:0034374)5.22514681
36plasma lipoprotein particle organization (GO:0071827)5.18921822
37cholesterol efflux (GO:0033344)5.18418508
38high-density lipoprotein particle remodeling (GO:0034375)5.18224497
39regulation of cholesterol homeostasis (GO:2000188)5.14712989
40regulation of fibrinolysis (GO:0051917)5.10148839
41cell recognition (GO:0008037)5.08422580
42plasma lipoprotein particle remodeling (GO:0034369)5.06593825
43protein-lipid complex remodeling (GO:0034368)5.06593825
44macromolecular complex remodeling (GO:0034367)5.06593825
45spermatid nucleus differentiation (GO:0007289)4.94083377
46microtubule severing (GO:0051013)4.93508427
47male meiosis I (GO:0007141)4.92171485
48protein-lipid complex subunit organization (GO:0071825)4.90984326
49DNA methylation involved in gamete generation (GO:0043046)4.81864683
50reverse cholesterol transport (GO:0043691)4.74361983
51glycerol ether metabolic process (GO:0006662)4.67708828
52regulation of protein activation cascade (GO:2000257)4.62271408
53chromosome organization involved in meiosis (GO:0070192)4.61230837
54multicellular organismal reproductive process (GO:0048609)4.55694514
55regulation of apoptotic cell clearance (GO:2000425)4.55002971
56regulation of complement activation (GO:0030449)4.50495878
57seminiferous tubule development (GO:0072520)4.42176014
58plasma lipoprotein particle clearance (GO:0034381)4.40381947
59left/right pattern formation (GO:0060972)4.33104281
60ether metabolic process (GO:0018904)4.31920062
61meiotic nuclear division (GO:0007126)4.29192381
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.24560877
63phospholipid efflux (GO:0033700)4.17403521
64regulation of plasminogen activation (GO:0010755)4.10835523
65regulation of cholesterol biosynthetic process (GO:0045540)4.08822392
66diacylglycerol metabolic process (GO:0046339)4.05260971
67positive regulation of hormone metabolic process (GO:0032352)3.95814670
68chromosome condensation (GO:0030261)3.91711521
69meiosis I (GO:0007127)3.90013585
70negative regulation of sterol transport (GO:0032372)3.88583858
71negative regulation of cholesterol transport (GO:0032375)3.88583858
72regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.85250162
73intestinal absorption (GO:0050892)3.84778297
74chaperone-mediated protein complex assembly (GO:0051131)3.76724062
75DNA packaging (GO:0006323)3.75661121
76protein polyglutamylation (GO:0018095)3.73418730
77blood coagulation, intrinsic pathway (GO:0007597)3.69369320
78multicellular organismal development (GO:0007275)3.68173626
79proline metabolic process (GO:0006560)3.67454366
80embryonic retina morphogenesis in camera-type eye (GO:0060059)3.64774616
81protein localization to cilium (GO:0061512)3.63784376
82regulation of bile acid biosynthetic process (GO:0070857)3.60642169
83monoubiquitinated protein deubiquitination (GO:0035520)3.56706686
84genitalia morphogenesis (GO:0035112)3.55251603
85positive regulation of hormone biosynthetic process (GO:0046886)3.54456860
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.50928747
87L-phenylalanine catabolic process (GO:0006559)3.50928747
88positive regulation of steroid metabolic process (GO:0045940)3.49299560
89low-density lipoprotein particle clearance (GO:0034383)3.49279080
90cellular zinc ion homeostasis (GO:0006882)3.48843316
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.45434120
92L-phenylalanine metabolic process (GO:0006558)3.45434120
93lipoprotein metabolic process (GO:0042157)3.41516698
94single strand break repair (GO:0000012)3.41162804
95sexual reproduction (GO:0019953)3.40343596
96meiotic cell cycle (GO:0051321)3.32500362
97cholesterol homeostasis (GO:0042632)3.32007682
98protein K11-linked deubiquitination (GO:0035871)3.28600790
99sterol homeostasis (GO:0055092)3.28394472
100polyol catabolic process (GO:0046174)3.28293486
1014-hydroxyproline metabolic process (GO:0019471)3.23541217
102intraciliary transport (GO:0042073)3.22419006
103proline biosynthetic process (GO:0006561)3.20778632
104receptor catabolic process (GO:0032801)3.20611542
105positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.20306951
106regulation of cholesterol metabolic process (GO:0090181)3.20152438
107desmosome organization (GO:0002934)3.20110762
108lactate metabolic process (GO:0006089)3.18180562
109microtubule polymerization or depolymerization (GO:0031109)3.18130293
110basement membrane organization (GO:0071711)3.15590536
111cilium organization (GO:0044782)3.14184401
112negative regulation of sodium ion transport (GO:0010766)3.13032840
113positive regulation of lipoprotein lipase activity (GO:0051006)3.12295466
114positive regulation of triglyceride lipase activity (GO:0061365)3.12295466
115cholesterol transport (GO:0030301)3.12131537
116sterol transport (GO:0015918)3.12131537
117nephron tubule morphogenesis (GO:0072078)3.11565463
118nephron epithelium morphogenesis (GO:0072088)3.11565463
119microtubule-based movement (GO:0007018)3.08709032
120nucleoside diphosphate phosphorylation (GO:0006165)3.08423792
121protein refolding (GO:0042026)3.06981451
122cell-cell junction maintenance (GO:0045217)3.06833462
123glycolytic process (GO:0006096)3.06569937
124negative regulation of protein activation cascade (GO:2000258)3.05247677
125amino-acid betaine transport (GO:0015838)3.05219381
126carnitine transport (GO:0015879)3.05219381
127cilium morphogenesis (GO:0060271)3.04383123
128negative regulation of organelle assembly (GO:1902116)3.04267471
129cilium assembly (GO:0042384)3.03825875
130alditol metabolic process (GO:0019400)3.02652325
131sequestering of actin monomers (GO:0042989)3.02108234
132negative regulation of lipase activity (GO:0060192)2.99845879
133histone H3-K9 demethylation (GO:0033169)2.97777695
134positive regulation of extracellular matrix organization (GO:1903055)2.97117544
135regulation of spindle checkpoint (GO:0090231)2.96006058
136response to vitamin A (GO:0033189)2.95733005
137trivalent inorganic anion homeostasis (GO:0072506)2.93056375
138phosphate ion homeostasis (GO:0055062)2.93056375
139carnitine transmembrane transport (GO:1902603)2.91396085
140cellular component assembly involved in morphogenesis (GO:0010927)2.89359178
141glutamate metabolic process (GO:0006536)2.88916532
142axoneme assembly (GO:0035082)2.88177056
143cell junction maintenance (GO:0034331)2.87197255
144GTP biosynthetic process (GO:0006183)2.86192623
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.82908278
146synapsis (GO:0007129)2.82823942
147complement activation, alternative pathway (GO:0006957)2.80981998
148regulation of glycogen (starch) synthase activity (GO:2000465)2.80216897
149nucleus organization (GO:0006997)2.80057877
150positive regulation of insulin receptor signaling pathway (GO:0046628)2.78884244
151lipid homeostasis (GO:0055088)2.78657314
152negative regulation of fatty acid biosynthetic process (GO:0045717)2.78586087
153transepithelial transport (GO:0070633)2.78338077
154phosphatidylethanolamine biosynthetic process (GO:0006646)2.78247749
155regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.78002257
156positive regulation of synapse maturation (GO:0090129)2.77801296
157regulation of fatty acid biosynthetic process (GO:0042304)2.77155374
158modified amino acid transport (GO:0072337)2.75506094
159glucose 6-phosphate metabolic process (GO:0051156)2.73475238
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.71193098
161meiotic cell cycle process (GO:1903046)2.69877612
162acute-phase response (GO:0006953)2.68923274
163endocardial cushion development (GO:0003197)2.68486967
164protein retention in ER lumen (GO:0006621)2.68283015
165regulation of extracellular matrix organization (GO:1903053)2.68083284
166dicarboxylic acid biosynthetic process (GO:0043650)2.67983468
167cellular anion homeostasis (GO:0030002)2.66965947
168triglyceride homeostasis (GO:0070328)2.66638855
169acylglycerol homeostasis (GO:0055090)2.66638855
170renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.66575563
171bundle of His cell to Purkinje myocyte communication (GO:0086069)2.64973446
172glycerol metabolic process (GO:0006071)2.60877422
173peptidyl-glutamic acid modification (GO:0018200)2.60871048
174regulation of cholesterol storage (GO:0010885)2.59745652
175regulation of cilium assembly (GO:1902017)2.59632891
176cell proliferation involved in metanephros development (GO:0072203)2.59466705
177gene silencing by RNA (GO:0031047)2.54892608
178centriole assembly (GO:0098534)2.54483071
179positive regulation of macrophage activation (GO:0043032)2.53233972
180mitotic sister chromatid cohesion (GO:0007064)2.52318743
181UTP biosynthetic process (GO:0006228)2.50584560
182interferon-gamma secretion (GO:0072643)2.47346230
183calcium ion import (GO:0070509)2.46571832
184cell redox homeostasis (GO:0045454)2.43059325
185RNA destabilization (GO:0050779)2.37568768
186fusion of sperm to egg plasma membrane (GO:0007342)14.2259259
187sperm motility (GO:0030317)13.4162873
188cell wall macromolecule metabolic process (GO:0044036)12.7088645
189cell wall macromolecule catabolic process (GO:0016998)12.7088645
190acrosome reaction (GO:0007340)11.7746740
191acrosome assembly (GO:0001675)11.5340885
192multicellular organism reproduction (GO:0032504)11.5289804
193sperm-egg recognition (GO:0035036)11.5149296
194cilium or flagellum-dependent cell motility (GO:0001539)11.0422405
195plasma membrane fusion (GO:0045026)10.8866545
196cell-cell recognition (GO:0009988)10.3001261
197binding of sperm to zona pellucida (GO:0007339)10.2648130
198axonemal dynein complex assembly (GO:0070286)10.2640978
199epithelial cilium movement (GO:0003351)10.0660028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.06836118
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.11585635
3EZH2_22144423_ChIP-Seq_EOC_Human4.70439282
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.27339841
5FOXA2_19822575_ChIP-Seq_HepG2_Human3.20612358
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.15146376
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03989106
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.01760867
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94874808
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90486668
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.85622054
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.78149453
13ZNF263_19887448_ChIP-Seq_K562_Human2.73095843
14LXR_22292898_ChIP-Seq_THP-1_Human2.71692846
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69492445
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.65426999
17VDR_22108803_ChIP-Seq_LS180_Human2.56862367
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.45842381
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.41941640
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27602005
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26772784
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19445391
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18811219
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16741917
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12037026
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.09365369
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.08085720
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07359306
29HNF4A_19822575_ChIP-Seq_HepG2_Human2.06949781
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02789117
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00714064
32ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00492671
33RACK7_27058665_Chip-Seq_MCF-7_Human2.00079873
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98024921
35ZNF274_21170338_ChIP-Seq_K562_Hela1.94950794
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94299108
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91758201
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90120127
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86716841
40KDM2B_26808549_Chip-Seq_K562_Human1.84229694
41SMC4_20622854_ChIP-Seq_HELA_Human1.84186550
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.83020252
43P68_20966046_ChIP-Seq_HELA_Human1.81896603
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.80765755
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.80659521
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.78452054
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.75098870
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.74214326
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71400617
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69210642
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.69190035
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68556131
53STAT1_17558387_ChIP-Seq_HELA_Human1.67871107
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.67745952
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.67183608
56TCF7_22412390_ChIP-Seq_EML_Mouse1.59965874
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59720782
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58898448
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.58062599
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.56523275
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56030749
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56012351
63KDM2B_26808549_Chip-Seq_REH_Human1.54062974
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54005147
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.53407445
66FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53087409
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.52960239
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51851977
69REST_21632747_ChIP-Seq_MESCs_Mouse1.51283457
70CBP_20019798_ChIP-Seq_JUKART_Human1.49538061
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49538061
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47702458
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45850299
74TAF15_26573619_Chip-Seq_HEK293_Human1.45791087
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45679867
76GATA6_25053715_ChIP-Seq_YYC3_Human1.45377650
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.43972784
78SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42793682
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42640126
80CLOCK_20551151_ChIP-Seq_293T_Human1.41883831
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41537229
82CREB1_26743006_Chip-Seq_LNCaP_Human1.41519283
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39575705
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36811608
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36390738
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.36102988
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.36028726
88CTCF_27219007_Chip-Seq_Bcells_Human1.35993917
89TP53_22127205_ChIP-Seq_IMR90_Human1.34739389
90KDM2B_26808549_Chip-Seq_DND41_Human1.32797248
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.32477078
92MYC_22102868_ChIP-Seq_BL_Human1.31496106
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30695699
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30520874
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29785079
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.29063557
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28705702
98VDR_21846776_ChIP-Seq_THP-1_Human1.28471560
99LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26503440
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26031814
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.25985780
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.25463820
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25271669
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24972879
105DROSHA_22980978_ChIP-Seq_HELA_Human1.24859401
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24712599
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24275255
108P53_21459846_ChIP-Seq_SAOS-2_Human1.23864561
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21597620
110GATA4_25053715_ChIP-Seq_YYC3_Human1.21499166
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20040903
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19917217
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18707570
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.18036936
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.17755594
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.17606690
117BCOR_27268052_Chip-Seq_Bcells_Human1.17482086
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17286496
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.17268817
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17058765
121FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16737154
122AR_21572438_ChIP-Seq_LNCaP_Human1.16672182
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15336413
124GF1_26923725_Chip-Seq_HPCs_Mouse1.15288590
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15285476
126RNF2_27304074_Chip-Seq_NSC_Mouse1.14916617
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14444692
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14434045
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14434045
130CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13085153
131RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13062694
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12808972
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11312659
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09649562
135SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09535674
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09013883
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08914170
138RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08807708
139PHF8_20622854_ChIP-Seq_HELA_Human1.08532617
140CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08507517
141P53_22387025_ChIP-Seq_ESCs_Mouse1.08348876
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07826482
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07787983
144ATF3_27146783_Chip-Seq_COLON_Human1.07402692
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06830673
146TP63_22573176_ChIP-Seq_HFKS_Human1.06728885
147RARB_24833708_ChIP-Seq_LIVER_Mouse1.05846848
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05818166
149OCT4_18555785_Chip-Seq_ESCs_Mouse1.05356821
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04265843
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03454597
152ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03122547
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03122186
154E2F1_20622854_ChIP-Seq_HELA_Human1.03107626
155CMYC_18555785_Chip-Seq_ESCs_Mouse1.02992425
156GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02786137
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02725077
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02326017
159SA1_27219007_Chip-Seq_ERYTHROID_Human1.01007881
160EZH2_27294783_Chip-Seq_NPCs_Mouse1.00674713
161P300_18555785_Chip-Seq_ESCs_Mouse0.99683866
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99420494
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98939224
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.98714925
165ELF1_20517297_ChIP-Seq_JURKAT_Human0.98706912
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98400873
167RAC3_21632823_ChIP-Seq_H3396_Human0.98122386
168ERG_20517297_ChIP-Seq_VCAP_Human0.97995647
169JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97662625
170SPI1_26923725_Chip-Seq_HPCs_Mouse0.97636191
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96941015
172SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96547477
173ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96072300
174PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95747737
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.95501196
176SOX9_26525672_Chip-Seq_HEART_Mouse0.94813351
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94363014
178UBF1/2_26484160_Chip-Seq_HMECs_Human0.94342080
179YY1_22570637_ChIP-Seq_MALME-3M_Human0.93418759
180EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93228713
181NFYB_21822215_ChIP-Seq_K562_Human0.93027925
182KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92648930
183PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92192077
184ESET_19884257_ChIP-Seq_ESCs_Mouse0.91152056
185STAT3_18555785_Chip-Seq_ESCs_Mouse0.90904139
186CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90843528
187RARA_24833708_ChIP-Seq_LIVER_Mouse0.90312154
188SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90238445
189SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89861894
190GF1B_26923725_Chip-Seq_HPCs_Mouse0.88626905
191SMAD4_21741376_ChIP-Seq_EPCs_Human0.88259241
192PU1_27457419_Chip-Seq_LIVER_Mouse0.86837098
193RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85619475
194LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85482716
195SOX2_18555785_Chip-Seq_ESCs_Mouse0.85289982
196CTCF_18555785_Chip-Seq_ESCs_Mouse0.85109577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.00195311
2MP0001929_abnormal_gametogenesis5.38809276
3MP0003122_maternal_imprinting5.20936362
4MP0005360_urolithiasis4.52653883
5MP0008877_abnormal_DNA_methylation4.31491122
6MP0000566_synostosis3.68192330
7MP0003123_paternal_imprinting3.52132917
8MP0004264_abnormal_extraembryonic_tissu3.38125290
9MP0002210_abnormal_sex_determination3.36591079
10MP0002161_abnormal_fertility/fecundity3.25506426
11MP0010329_abnormal_lipoprotein_level2.96503285
12MP0001666_abnormal_nutrient_absorption2.93563977
13MP0001145_abnormal_male_reproductive2.85758633
14MP0005058_abnormal_lysosome_morphology2.74869156
15MP0005451_abnormal_body_composition2.71053013
16MP0003172_abnormal_lysosome_physiology2.70020834
17MP0009840_abnormal_foam_cell2.69341770
18MP0005670_abnormal_white_adipose2.61067624
19MP0002653_abnormal_ependyma_morphology2.57362760
20MP0000653_abnormal_sex_gland2.49572114
21MP0002089_abnormal_postnatal_growth/wei2.45876711
22MP0005409_darkened_coat_color2.41479919
23MP0005085_abnormal_gallbladder_physiolo2.12944442
24MP0005076_abnormal_cell_differentiation2.11423070
25MP0003195_calcinosis2.02891416
26MP0005410_abnormal_fertilization15.9951399
27MP0002132_abnormal_respiratory_system1.93971903
28MP0003315_abnormal_perineum_morphology1.90551427
29MP0005623_abnormal_meninges_morphology1.74093224
30MP0002160_abnormal_reproductive_system1.72766460
31MP0008875_abnormal_xenobiotic_pharmacok1.71377053
32MP0002249_abnormal_larynx_morphology1.67464630
33MP0003567_abnormal_fetal_cardiomyocyte1.67069793
34MP0001984_abnormal_olfaction1.59256888
35MP0009046_muscle_twitch1.58740544
36MP0000678_abnormal_parathyroid_gland1.49629277
37MP0009384_cardiac_valve_regurgitation1.49611016
38MP0004233_abnormal_muscle_weight1.45102490
39MP0003121_genomic_imprinting1.42973042
40MP0001915_intracranial_hemorrhage1.33849213
41MP0004272_abnormal_basement_membrane1.33793836
42MP0009780_abnormal_chondrocyte_physiolo1.30267116
43MP0005646_abnormal_pituitary_gland1.29733984
44MP0000639_abnormal_adrenal_gland1.29450289
45MP0003868_abnormal_feces_composition1.28939870
46MP0002118_abnormal_lipid_homeostasis1.28843729
47MP0001765_abnormal_ion_homeostasis1.26706154
48MP0003646_muscle_fatigue1.26071880
49MP0000609_abnormal_liver_physiology1.24011105
50MP0005257_abnormal_intraocular_pressure1.23143148
51MP0002282_abnormal_trachea_morphology1.17308931
52MP0003385_abnormal_body_wall1.16467041
53MP0005408_hypopigmentation1.11371659
54MP0010368_abnormal_lymphatic_system1.07689149
55MP0000537_abnormal_urethra_morphology1.06263179
56MP0000003_abnormal_adipose_tissue1.03524604
57MP0001270_distended_abdomen1.00753150
58MP0005647_abnormal_sex_gland0.95035947
59MP0010234_abnormal_vibrissa_follicle0.94924435
60MP0005220_abnormal_exocrine_pancreas0.94120554
61MP0002102_abnormal_ear_morphology0.93937333
62MP0005332_abnormal_amino_acid0.93770376
63MP0003632_abnormal_nervous_system0.92591875
64MP0010630_abnormal_cardiac_muscle0.91778687
65MP0008058_abnormal_DNA_repair0.89568045
66MP0005389_reproductive_system_phenotype0.88336067
67MP0001849_ear_inflammation0.86912862
68MP0001348_abnormal_lacrimal_gland0.85890220
69MP0005330_cardiomyopathy0.85854582
70MP0002092_abnormal_eye_morphology0.81393475
71MP0004858_abnormal_nervous_system0.81216782
72MP0002086_abnormal_extraembryonic_tissu0.79223232
73MP0002933_joint_inflammation0.78613414
74MP0000598_abnormal_liver_morphology0.77911259
75MP0002234_abnormal_pharynx_morphology0.76162500
76MP0001346_abnormal_lacrimal_gland0.76129380
77MP0008995_early_reproductive_senescence0.75389858
78MP0005551_abnormal_eye_electrophysiolog0.74377363
79MP0002928_abnormal_bile_duct0.73705571
80MP0001756_abnormal_urination0.72368543
81MP0004185_abnormal_adipocyte_glucose0.72080611
82MP0003943_abnormal_hepatobiliary_system0.71975998
83MP0005375_adipose_tissue_phenotype0.70587703
84MP0003329_amyloid_beta_deposits0.70015144
85MP0005636_abnormal_mineral_homeostasis0.69364526
86MP0003566_abnormal_cell_adhesion0.68703165
87MP0003252_abnormal_bile_duct0.68373721
88MP0003705_abnormal_hypodermis_morpholog0.67396023
89MP0001324_abnormal_eye_pigmentation0.66250783
90MP0005083_abnormal_biliary_tract0.65978935
91MP0002736_abnormal_nociception_after0.64201910
92MP0005248_abnormal_Harderian_gland0.63004643
93MP0002078_abnormal_glucose_homeostasis0.62227526
94MP0003011_delayed_dark_adaptation0.60948638
95MP0002822_catalepsy0.60499756
96MP0003984_embryonic_growth_retardation0.59765089
97MP0003941_abnormal_skin_development0.59538862
98MP0002098_abnormal_vibrissa_morphology0.59091418
99MP0003115_abnormal_respiratory_system0.58892382
100MP0009643_abnormal_urine_homeostasis0.58821626
101MP0000358_abnormal_cell_content/0.58317724
102MP0009642_abnormal_blood_homeostasis0.57779204
103MP0004270_analgesia0.57370987
104MP0005448_abnormal_energy_balance0.57200595
105MP0008260_abnormal_autophagy0.57200420
106MP0002116_abnormal_craniofacial_bone0.56627999
107MP0002088_abnormal_embryonic_growth/wei0.56463550
108MP0003191_abnormal_cellular_cholesterol0.55996129
109MP0003283_abnormal_digestive_organ0.55930256
110MP0003935_abnormal_craniofacial_develop0.55837088
111MP0003879_abnormal_hair_cell0.54958696
112MP0002269_muscular_atrophy0.51434479
113MP0005645_abnormal_hypothalamus_physiol0.51216425
114MP0001968_abnormal_touch/_nociception0.50680910
115MP0005253_abnormal_eye_physiology0.46788155
116MP0003878_abnormal_ear_physiology0.45645891
117MP0005377_hearing/vestibular/ear_phenot0.45645891
118MP0001727_abnormal_embryo_implantation0.45163563
119MP0004036_abnormal_muscle_relaxation0.44466774
120MP0002909_abnormal_adrenal_gland0.44417603
121MP0003699_abnormal_female_reproductive0.44207533
122MP0003635_abnormal_synaptic_transmissio0.44173703
123MP0002139_abnormal_hepatobiliary_system0.43355159
124MP0004811_abnormal_neuron_physiology0.43236911
125MP0001764_abnormal_homeostasis0.41504661
126MP0004859_abnormal_synaptic_plasticity0.40533654
127MP0004043_abnormal_pH_regulation0.40319797
128MP0002572_abnormal_emotion/affect_behav0.40226681
129MP0008569_lethality_at_weaning0.39176488
130MP0005666_abnormal_adipose_tissue0.38640777
131MP0003633_abnormal_nervous_system0.38309850
132MP0001440_abnormal_grooming_behavior0.37536342
133MP0002693_abnormal_pancreas_physiology0.37505562
134MP0002971_abnormal_brown_adipose0.36952539
135MP0006036_abnormal_mitochondrial_physio0.36781395
136MP0002063_abnormal_learning/memory/cond0.36206177
137MP0001293_anophthalmia0.35143699
138MP0000751_myopathy0.34769966
139MP0002229_neurodegeneration0.34389232
140MP0003786_premature_aging0.34265025
141MP0002152_abnormal_brain_morphology0.33799025
142MP0010094_abnormal_chromosome_stability0.33036879
143MP0004742_abnormal_vestibular_system0.32174329
144MP0006072_abnormal_retinal_apoptosis0.31631027
145MP0000569_abnormal_digit_pigmentation0.31029557
146MP0002272_abnormal_nervous_system0.30804870
147MP0006035_abnormal_mitochondrial_morpho0.30058745
148MP0003787_abnormal_imprinting0.29754180
149MP0008961_abnormal_basal_metabolism0.29714952
150MP0009115_abnormal_fat_cell0.28547142
151MP0005391_vision/eye_phenotype0.28498432
152MP0005174_abnormal_tail_pigmentation0.28473639
153MP0003183_abnormal_peptide_metabolism0.28161114
154MP0003861_abnormal_nervous_system0.27711537
155MP0005365_abnormal_bile_salt0.27659315
156MP0003631_nervous_system_phenotype0.27614940
157MP0002067_abnormal_sensory_capabilities0.27248077
158MP0002796_impaired_skin_barrier0.27181935
159MP0003942_abnormal_urinary_system0.26807190
160MP0001119_abnormal_female_reproductive0.25706948
161MP0009745_abnormal_behavioral_response0.25060153
162MP0004019_abnormal_vitamin_homeostasis0.24950622
163MP0002064_seizures0.24664737
164MP0005535_abnormal_body_temperature0.24594362
165MP0003959_abnormal_lean_body0.24278204
166MP0002557_abnormal_social/conspecific_i0.24186081
167MP0003950_abnormal_plasma_membrane0.24168970
168MP0000534_abnormal_ureter_morphology0.23106320
169MP0000604_amyloidosis0.22382961
170MP0001661_extended_life_span0.22199447
171MP0002882_abnormal_neuron_morphology0.22118396
172MP0003953_abnormal_hormone_level0.20909727
173MP0001986_abnormal_taste_sensitivity0.20707005
174MP0002169_no_abnormal_phenotype0.20678363
175MP0005423_abnormal_somatic_nervous0.20552406
176MP0005195_abnormal_posterior_eye0.20460774

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.37567956
2Abnormal respiratory motile cilium morphology (HP:0005938)9.26049637
3Abnormal respiratory epithelium morphology (HP:0012253)9.26049637
4Deep venous thrombosis (HP:0002625)8.55149437
5Abnormal ciliary motility (HP:0012262)7.64035993
6Rhinitis (HP:0012384)7.56294864
7Chronic bronchitis (HP:0004469)7.21233879
8Infertility (HP:0000789)6.59588920
9Nasal polyposis (HP:0100582)6.22435054
10Prolonged partial thromboplastin time (HP:0003645)5.80946500
11Joint hemorrhage (HP:0005261)5.11949701
12Abnormality of the nasal mucosa (HP:0000433)5.07741457
13Bronchitis (HP:0012387)4.48776502
14Bronchiectasis (HP:0002110)4.40725493
15Male infertility (HP:0003251)4.36443709
16Nephronophthisis (HP:0000090)4.34292300
17Abnormality of the common coagulation pathway (HP:0010990)4.16766295
18Asymmetry of the thorax (HP:0001555)4.14785954
19Flat acetabular roof (HP:0003180)4.11348563
20Hypobetalipoproteinemia (HP:0003563)4.07437599
21Abnormal tarsal ossification (HP:0008369)3.97005770
22Hypercholesterolemia (HP:0003124)3.75475597
23Abnormality of carpal bone ossification (HP:0006257)3.64105389
24Complement deficiency (HP:0004431)3.45209199
25Abnormal spermatogenesis (HP:0008669)3.41784967
26Small epiphyses (HP:0010585)3.41050095
27Recurrent sinusitis (HP:0011108)3.39509221
28Abnormality of the renal medulla (HP:0100957)3.26577738
29Broad alveolar ridges (HP:0000187)3.20864338
30Recurrent otitis media (HP:0000403)3.19995277
31Menorrhagia (HP:0000132)3.17462736
32Broad palm (HP:0001169)3.15514060
33Epiphyseal dysplasia (HP:0002656)3.15107579
34Xanthomatosis (HP:0000991)3.14784493
35Hypolipoproteinemia (HP:0010981)3.08709298
36Glomerulonephritis (HP:0000099)3.06332628
37Abnormality of the lumbar spine (HP:0100712)3.02361734
38Acanthocytosis (HP:0001927)3.00723382
39Spontaneous abortion (HP:0005268)3.00647768
40Tubulointerstitial nephritis (HP:0001970)2.94591630
41Abnormal ossification of hand bones (HP:0005921)2.91927390
42Medial flaring of the eyebrow (HP:0010747)2.89928351
43Abnormality of midbrain morphology (HP:0002418)2.87934586
44Molar tooth sign on MRI (HP:0002419)2.87934586
45Vaginal fistula (HP:0004320)2.78683139
46Abnormality of the nasal septum (HP:0000419)2.76906852
47Abnormal hand bone ossification (HP:0010660)2.76772954
48Recurrent bronchitis (HP:0002837)2.67138250
49Abnormal foot bone ossification (HP:0010675)2.53227522
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49954803
51Hepatoblastoma (HP:0002884)2.48110666
52Abnormality of complement system (HP:0005339)2.47283672
53Enlarged kidneys (HP:0000105)2.47196532
54Hypophosphatemic rickets (HP:0004912)2.46808888
55Hypoalphalipoproteinemia (HP:0003233)2.46533815
56Tubular atrophy (HP:0000092)2.45409607
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43228698
58Gonadotropin excess (HP:0000837)2.37629671
59Tubulointerstitial abnormality (HP:0001969)2.35256711
60Right ventricular cardiomyopathy (HP:0011663)2.34801429
61Impulsivity (HP:0100710)2.30478684
62Alacrima (HP:0000522)2.26635027
63Widely patent fontanelles and sutures (HP:0004492)2.24335140
64Cupped ribs (HP:0000887)2.20466287
65Delayed epiphyseal ossification (HP:0002663)2.19640559
66Pigmentary retinal degeneration (HP:0001146)2.19638689
67Limited elbow extension (HP:0001377)2.19012631
68Irregular epiphyses (HP:0010582)2.18798312
69Abnormality of the lacrimal duct (HP:0011481)2.17419487
70Azoospermia (HP:0000027)2.15630999
71Retinal atrophy (HP:0001105)2.14886515
72Vitreoretinal degeneration (HP:0000655)2.12370860
73Flared iliac wings (HP:0002869)2.11453900
74Abnormality of the pubic bones (HP:0003172)2.10319678
75Neonatal short-limb short stature (HP:0008921)2.09953576
76Vascular calcification (HP:0004934)2.09354603
77Abnormal gallbladder physiology (HP:0012438)2.08341654
78Cholecystitis (HP:0001082)2.08341654
79Midline defect of the nose (HP:0004122)2.06966373
80Intrahepatic cholestasis (HP:0001406)2.05662740
81Bronchomalacia (HP:0002780)2.05503603
82Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02655821
83Diastasis recti (HP:0001540)2.00230138
84Dynein arm defect of respiratory motile cilia (HP:0012255)13.4211738
85Absent/shortened dynein arms (HP:0200106)13.4211738
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1915540
87Postaxial foot polydactyly (HP:0001830)1.99617087
88Abnormality of the acetabulum (HP:0003170)1.98822316
89Myelomeningocele (HP:0002475)1.97931685
90Intestinal fistula (HP:0100819)1.97739111
91Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95279514
92Thin bony cortex (HP:0002753)1.94490479
93Cerebral aneurysm (HP:0004944)1.94396235
94Pancreatic islet-cell hyperplasia (HP:0004510)1.93712059
95Anal stenosis (HP:0002025)1.93372718
96Abnormality of the intrinsic pathway (HP:0010989)1.93042830
97Osteomalacia (HP:0002749)1.92378026
98Congenital primary aphakia (HP:0007707)1.90155213
99Gait imbalance (HP:0002141)1.90070510
100Systemic lupus erythematosus (HP:0002725)1.89801368
101Gingival bleeding (HP:0000225)1.89300635
102Dyschromatopsia (HP:0007641)1.88540506
103Flattened epiphyses (HP:0003071)1.88502986
104Facial hemangioma (HP:0000329)1.88404482
105Purpura (HP:0000979)1.86471494
106Partial duplication of thumb phalanx (HP:0009944)1.86412499
107Choanal stenosis (HP:0000452)1.85570936
108Bifid scrotum (HP:0000048)1.85029190
109Abnormality of the wing of the ilium (HP:0011867)1.84496617
110Neonatal death (HP:0003811)1.82633596
111Testicular neoplasm (HP:0010788)1.82472648
112Impaired pain sensation (HP:0007328)1.82439105
113Abnormality of pain sensation (HP:0010832)1.82439105
114Stage 5 chronic kidney disease (HP:0003774)1.82227856
115Congenital hepatic fibrosis (HP:0002612)1.81264663
116Protrusio acetabuli (HP:0003179)1.80725957
117Rectal prolapse (HP:0002035)1.80153532
118Wide nose (HP:0000445)1.79942554
119Mitral stenosis (HP:0001718)1.79881152
120Abnormality of the fingertips (HP:0001211)1.78759539
121Potter facies (HP:0002009)1.78120025
122Facial shape deformation (HP:0011334)1.78120025
123Ulnar bowing (HP:0003031)1.78011020
124Cervical subluxation (HP:0003308)1.77609238
125Mucopolysacchariduria (HP:0008155)1.77335614
126Urinary glycosaminoglycan excretion (HP:0003541)1.77335614
127Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.77023800
128Advanced eruption of teeth (HP:0006288)1.77013259
129Spastic tetraparesis (HP:0001285)1.77008607
130Decreased central vision (HP:0007663)1.76839928
131Abnormality of the vitreous humor (HP:0004327)1.75808847
132Tubulointerstitial fibrosis (HP:0005576)1.75261855
133Cardiovascular calcification (HP:0011915)1.75053340
134Abnormality of the nasolacrimal system (HP:0000614)1.74458170
135Abnormality of the lower motor neuron (HP:0002366)1.74322371
136Oculomotor apraxia (HP:0000657)1.74184227
137Renal duplication (HP:0000075)1.73746376
138Short femoral neck (HP:0100864)1.71781094
139Abnormality of the renal cortex (HP:0011035)1.66425617
140Polydipsia (HP:0001959)1.65849614
141Abnormal drinking behavior (HP:0030082)1.65849614
142Aplasia/Hypoplasia of the lens (HP:0008063)1.65047246
143Heterotopia (HP:0002282)1.64295591
144Postaxial hand polydactyly (HP:0001162)1.62937488
145Nephrogenic diabetes insipidus (HP:0009806)1.62083679
146Choroideremia (HP:0001139)1.61714000
147Taurodontia (HP:0000679)1.60589669
148Abnormality of permanent molar morphology (HP:0011071)1.60589669
149Abnormality of the dental root (HP:0006486)1.60589669
150Microglossia (HP:0000171)1.59672695
151Pancreatic fibrosis (HP:0100732)1.59457814
152Bell-shaped thorax (HP:0001591)1.57610580
153Short ribs (HP:0000773)1.57398925
154Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57264177
155Cystic liver disease (HP:0006706)1.52311660
156Abnormality of molar (HP:0011077)1.52021067
157Abnormality of molar morphology (HP:0011070)1.52021067
158Fibular hypoplasia (HP:0003038)1.51174019
159Cerebellar dysplasia (HP:0007033)1.50987516
160Chronic sinusitis (HP:0011109)1.50057400
161Abnormality of dentin (HP:0010299)1.49274492
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.48603353
163Abnormality of the dental pulp (HP:0006479)1.47061845
164Abnormality of renal excretion (HP:0011036)1.46923274
165Abnormality of ocular smooth pursuit (HP:0000617)1.46092441
166Bile duct proliferation (HP:0001408)1.46021296
167Abnormal biliary tract physiology (HP:0012439)1.46021296
168Genital tract atresia (HP:0001827)1.45907959
169Vaginal atresia (HP:0000148)1.45207879
170True hermaphroditism (HP:0010459)1.44265103
171J-shaped sella turcica (HP:0002680)1.43239052
172Abnormality of saccadic eye movements (HP:0000570)1.43182732
173Facial cleft (HP:0002006)1.41753431
174Neurofibrillary tangles (HP:0002185)1.41259168
175Renal dysplasia (HP:0000110)1.39808798
176Amyotrophic lateral sclerosis (HP:0007354)1.39636649
177Poor coordination (HP:0002370)1.36464733
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.35998961
179Sensory axonal neuropathy (HP:0003390)1.34914006
180Hemiparesis (HP:0001269)1.34868071
181Deformed sella turcica (HP:0002681)1.31682041
182Broad distal phalanx of finger (HP:0009836)1.30237468
183Retinal dysplasia (HP:0007973)1.29738878
184Hemorrhage of the eye (HP:0011885)1.28914931
185Nephropathy (HP:0000112)1.26506915
186Asymmetric septal hypertrophy (HP:0001670)1.26444799
187Absent frontal sinuses (HP:0002688)1.26130971
188Bundle branch block (HP:0011710)1.25493368
189Median cleft lip (HP:0000161)1.23870055
190Impaired smooth pursuit (HP:0007772)1.23718715
191Glucose intolerance (HP:0000833)1.21239348
192Short thorax (HP:0010306)1.21038784
193Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.20821684
194Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.19804225
195Absent epiphyses (HP:0010577)1.19804225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.41458363
2PDK38.41458363
3TESK15.65956483
4PDK25.35406360
5PRKD35.18301591
6FGFR44.66132931
7TRIB33.90294233
8ICK3.83745446
9PKN23.83540215
10CDK123.08749174
11FGFR33.08468236
12PTK2B2.38848190
13PNCK2.29406958
14EPHA22.28876549
15LATS12.28244285
16WNK42.19023336
17FGFR22.07935400
18ERN12.05972781
19SIK12.05106160
20AKT32.04426664
21PDGFRA2.00033999
22STK391.88609362
23RIPK11.86673875
24SIK21.69332876
25STK381.65590915
26RET1.53996759
27PIK3CA1.53793481
28LATS21.53468446
29DDR21.51766752
30FGFR11.48439942
31CAMK1D1.45323282
32SMG11.42214796
33DYRK1B1.41713922
34FLT31.25764189
35NEK21.21929710
36MAPK151.17877213
37MAPK111.17023544
38SGK2231.15610858
39SGK4941.15610858
40PRKAA21.13747708
41MST1R1.12501743
42MAP3K71.08519675
43PDK11.08281318
44PASK1.03253030
45CDC42BPA0.97577582
46CCNB10.94513724
47BRD40.90091067
48MAP3K20.89338849
49CAMK1G0.84065602
50IRAK30.80202517
51TYRO30.78887250
52WNK10.78805544
53RIPK40.78786607
54IRAK10.75955431
55NME10.75746445
56MET0.74216273
57DYRK30.73194327
58CDK70.73185980
59SGK30.72824618
60LMTK20.71112528
61MAP2K60.70321679
62PRKD20.69395297
63ERBB20.69076460
64NTRK20.68160621
65TNK20.62729710
66MAP2K30.61879532
67CHEK20.60649724
68SGK20.60559584
69MAPKAPK30.59729537
70PTK60.56429710
71PDPK10.55931571
72TESK20.55769947
73EEF2K0.55069977
74STK38L0.54077826
75PINK10.53694665
76FGR0.50381491
77TTK0.49986197
78RPS6KA20.48133915
79PDGFRB0.47015258
80MUSK0.46550145
81GRK60.44358426
82SGK10.44146450
83STK30.43833244
84CAMK40.41504992
85KSR20.39712200
86CAMKK10.39451292
87IRAK20.39058832
88WEE10.36276721
89PAK10.35425962
90PRKCG0.34686776
91CHEK10.33615602
92NEK60.33529531
93MAP2K20.33429940
94TAOK10.33357601
95BRSK20.32253752
96RPS6KB20.32026501
97PTK20.31789015
98CSF1R0.30327886
99PAK20.29649684
100CDK80.28854470
101MAPK10.28557317
102MAPK100.28163317
103RPS6KL10.27702289
104RPS6KC10.27702289
105CSNK1E0.27628957
106PBK0.26935223
107CDK40.26173885
108MELK0.25813397
109MARK20.25503593
110CDK90.24915578
111RPS6KA10.24849711
112MAPKAPK50.24795510
113ATM0.24457610
114MAP2K70.24235942
115NTRK30.23500536
116MTOR0.23463977
117OBSCN0.23200355
118BRSK10.23056237
119MAP3K60.22168094
120CSNK1A1L0.21993854
121INSRR0.19485686
122ATR0.19102294
123EPHA40.18720635
124PRKCZ0.17517762
125MINK10.17103571
126PAK60.16427626
127CDK150.16103374
128MAP3K40.16009702
129BRAF0.15507873
130PRKAA10.15084162
131RPS6KB10.14013631
132CDK180.13816848
133CAMK2A0.13346838
134CDK11A0.11986251
135CDK140.11175033
136STK110.11156210
137PKN10.09557873
138CDC70.08922907
139MAP2K40.07982022
140MAP3K100.07890886
141PLK10.07538373
142CAMK10.07339056
143MAP3K10.06899952
144PRKCQ0.06242952
145PAK40.06198116
146PRKG10.05659964
147MAP3K50.05647472
148GSK3B0.05340543
149MARK10.05080307
150PLK40.04727051
151PRKACG0.04517320
152CAMKK20.04380385
153PRKCB0.04030135
154CSNK2A10.03592990
155CDK50.03378252
156PRKCA0.03003913
157CSNK1D0.02847692
158CDK30.02117183
159MAPK80.01986883
160PRKACA0.01650288
161PRKDC0.01627573
162DAPK20.01117483
163CDK10.00551638
164FER0.00089832
165RPS6KA3-0.0150995
166CDK2-0.0139022
167CSNK2A2-0.0095656
168EGFR-0.0046928

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.31306743
2Complement and coagulation cascades_Homo sapiens_hsa046104.11273501
3Fatty acid biosynthesis_Homo sapiens_hsa000614.08584910
4Vitamin B6 metabolism_Homo sapiens_hsa007503.61062906
5Pyruvate metabolism_Homo sapiens_hsa006203.55688062
6Other glycan degradation_Homo sapiens_hsa005113.03780859
7Propanoate metabolism_Homo sapiens_hsa006402.80401809
8Glucagon signaling pathway_Homo sapiens_hsa049222.65986393
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57146568
10Linoleic acid metabolism_Homo sapiens_hsa005912.44778641
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41846431
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.37091085
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26582301
14Steroid biosynthesis_Homo sapiens_hsa001002.24295302
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13228058
16Arginine biosynthesis_Homo sapiens_hsa002202.12419467
17Vitamin digestion and absorption_Homo sapiens_hsa049772.08077391
18Basal transcription factors_Homo sapiens_hsa030222.06066101
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98027412
20Glycerolipid metabolism_Homo sapiens_hsa005611.95811136
21Selenocompound metabolism_Homo sapiens_hsa004501.94206664
22Amphetamine addiction_Homo sapiens_hsa050311.86453477
23Pentose phosphate pathway_Homo sapiens_hsa000301.84526333
24Oocyte meiosis_Homo sapiens_hsa041141.76942469
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.76221281
26PPAR signaling pathway_Homo sapiens_hsa033201.72185070
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62826584
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55258582
29Fructose and mannose metabolism_Homo sapiens_hsa000511.52048414
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.49516923
31Dorso-ventral axis formation_Homo sapiens_hsa043201.48608561
32Collecting duct acid secretion_Homo sapiens_hsa049661.46882214
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42006643
34Galactose metabolism_Homo sapiens_hsa000521.40481927
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.39794192
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38401121
37Renin secretion_Homo sapiens_hsa049241.38146033
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.37069675
39Carbon metabolism_Homo sapiens_hsa012001.36464646
40Phenylalanine metabolism_Homo sapiens_hsa003601.34494415
41Lysine degradation_Homo sapiens_hsa003101.33532723
42Cardiac muscle contraction_Homo sapiens_hsa042601.30289045
43Fatty acid metabolism_Homo sapiens_hsa012121.27816654
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27064274
45Huntingtons disease_Homo sapiens_hsa050161.26565598
46Insulin secretion_Homo sapiens_hsa049111.23890748
47Fatty acid degradation_Homo sapiens_hsa000711.22788763
48Fanconi anemia pathway_Homo sapiens_hsa034601.22682341
49Mineral absorption_Homo sapiens_hsa049781.22068653
50Arginine and proline metabolism_Homo sapiens_hsa003301.21462409
51Long-term potentiation_Homo sapiens_hsa047201.19110021
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16676464
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.16367669
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16088818
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13165060
56Insulin resistance_Homo sapiens_hsa049311.12335418
57Synaptic vesicle cycle_Homo sapiens_hsa047211.11410718
58Ether lipid metabolism_Homo sapiens_hsa005651.11409704
59Starch and sucrose metabolism_Homo sapiens_hsa005001.08181501
60Histidine metabolism_Homo sapiens_hsa003401.08055002
61Fat digestion and absorption_Homo sapiens_hsa049751.02243600
62Non-small cell lung cancer_Homo sapiens_hsa052231.01215921
63Insulin signaling pathway_Homo sapiens_hsa049100.98850740
64mTOR signaling pathway_Homo sapiens_hsa041500.98634366
65Taste transduction_Homo sapiens_hsa047420.97950818
66Purine metabolism_Homo sapiens_hsa002300.93152950
67Biosynthesis of amino acids_Homo sapiens_hsa012300.90533105
68Endometrial cancer_Homo sapiens_hsa052130.85883701
69Circadian entrainment_Homo sapiens_hsa047130.81400361
70Choline metabolism in cancer_Homo sapiens_hsa052310.81068937
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80871085
72Tyrosine metabolism_Homo sapiens_hsa003500.80189698
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79701943
74mRNA surveillance pathway_Homo sapiens_hsa030150.79030196
75Sphingolipid metabolism_Homo sapiens_hsa006000.78166808
76ECM-receptor interaction_Homo sapiens_hsa045120.77339115
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77088324
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76254709
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75965175
80Calcium signaling pathway_Homo sapiens_hsa040200.75886855
81Estrogen signaling pathway_Homo sapiens_hsa049150.72719252
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72709776
83Antigen processing and presentation_Homo sapiens_hsa046120.72386026
84Salivary secretion_Homo sapiens_hsa049700.72352087
85Renin-angiotensin system_Homo sapiens_hsa046140.72051685
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71761383
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70601023
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70002313
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69874940
90Sulfur relay system_Homo sapiens_hsa041220.69013486
91Thyroid hormone synthesis_Homo sapiens_hsa049180.67561883
92Pancreatic secretion_Homo sapiens_hsa049720.65286542
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.64582355
94HIF-1 signaling pathway_Homo sapiens_hsa040660.64565550
95Butanoate metabolism_Homo sapiens_hsa006500.63856709
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63297032
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.62991061
98Prion diseases_Homo sapiens_hsa050200.62647057
99Sulfur metabolism_Homo sapiens_hsa009200.62347917
100Basal cell carcinoma_Homo sapiens_hsa052170.62299891
101Olfactory transduction_Homo sapiens_hsa047400.61960923
102Inositol phosphate metabolism_Homo sapiens_hsa005620.61016047
103Gastric acid secretion_Homo sapiens_hsa049710.55937136
104Staphylococcus aureus infection_Homo sapiens_hsa051500.55509672
105Bladder cancer_Homo sapiens_hsa052190.55392981
106Glutathione metabolism_Homo sapiens_hsa004800.55353500
107RNA transport_Homo sapiens_hsa030130.55163262
108Hedgehog signaling pathway_Homo sapiens_hsa043400.54853427
109Arachidonic acid metabolism_Homo sapiens_hsa005900.54678445
110Chemical carcinogenesis_Homo sapiens_hsa052040.54636548
111Peroxisome_Homo sapiens_hsa041460.54314351
112Glutamatergic synapse_Homo sapiens_hsa047240.53579362
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53235500
114N-Glycan biosynthesis_Homo sapiens_hsa005100.52787091
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.52209550
116Bile secretion_Homo sapiens_hsa049760.51620880
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51105719
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.50751977
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49995946
120Adherens junction_Homo sapiens_hsa045200.49753449
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49752038
122Thyroid cancer_Homo sapiens_hsa052160.48241196
123Notch signaling pathway_Homo sapiens_hsa043300.46847338
124ABC transporters_Homo sapiens_hsa020100.46563176
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45783595
126Hippo signaling pathway_Homo sapiens_hsa043900.45359528
127Dopaminergic synapse_Homo sapiens_hsa047280.45148251
128Wnt signaling pathway_Homo sapiens_hsa043100.44502812
129Small cell lung cancer_Homo sapiens_hsa052220.44086954
130Cocaine addiction_Homo sapiens_hsa050300.43872213
131Proteoglycans in cancer_Homo sapiens_hsa052050.43407926
132Metabolic pathways_Homo sapiens_hsa011000.42651032
133cAMP signaling pathway_Homo sapiens_hsa040240.42640280
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.41954773
135Endocytosis_Homo sapiens_hsa041440.41942814
136Nicotine addiction_Homo sapiens_hsa050330.41913723
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41589658
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40942257
139Alcoholism_Homo sapiens_hsa050340.40741342
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40608333
141VEGF signaling pathway_Homo sapiens_hsa043700.40562911
142AMPK signaling pathway_Homo sapiens_hsa041520.40216983
143ErbB signaling pathway_Homo sapiens_hsa040120.39831813
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.39351732
145Chronic myeloid leukemia_Homo sapiens_hsa052200.38803889
146GnRH signaling pathway_Homo sapiens_hsa049120.38652320
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38041294
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38001775
149Legionellosis_Homo sapiens_hsa051340.36499089
150Focal adhesion_Homo sapiens_hsa045100.36105236
151Circadian rhythm_Homo sapiens_hsa047100.36013822
152Vibrio cholerae infection_Homo sapiens_hsa051100.35409611
153Protein digestion and absorption_Homo sapiens_hsa049740.34768418
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32564497
155Systemic lupus erythematosus_Homo sapiens_hsa053220.32379087
156Morphine addiction_Homo sapiens_hsa050320.29579897
157Type II diabetes mellitus_Homo sapiens_hsa049300.23572606
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23356640
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22261808

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