CCDC185

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.90771507
2axonemal dynein complex assembly (GO:0070286)9.88676022
3cilium or flagellum-dependent cell motility (GO:0001539)9.70792635
4spermatid development (GO:0007286)9.67820352
5reproduction (GO:0000003)9.65999597
6epithelial cilium movement (GO:0003351)9.62107937
7response to pheromone (GO:0019236)9.53364491
8regulation of cilium movement (GO:0003352)8.69009783
9cilium movement (GO:0003341)7.79088340
10single fertilization (GO:0007338)7.52955115
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.44749380
12sperm capacitation (GO:0048240)7.12234614
13negative regulation of inclusion body assembly (GO:0090084)7.02564108
14piRNA metabolic process (GO:0034587)7.00743639
15rRNA methylation (GO:0031167)6.80882593
16synaptonemal complex organization (GO:0070193)6.78895409
17microtubule depolymerization (GO:0007019)6.78713074
18male meiosis (GO:0007140)6.74483945
19spermatogenesis (GO:0007283)6.65648967
20organic cation transport (GO:0015695)6.64694778
21male gamete generation (GO:0048232)6.63159338
22synaptonemal complex assembly (GO:0007130)6.57381274
23cellular ketone body metabolic process (GO:0046950)6.40989010
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.34912917
25fertilization (GO:0009566)6.32796910
26gamete generation (GO:0007276)6.09855701
27regulation of inclusion body assembly (GO:0090083)5.86270189
28phosphatidylethanolamine metabolic process (GO:0046337)5.85783974
29rRNA modification (GO:0000154)5.74173937
30calcium ion-dependent exocytosis (GO:0017156)5.73188068
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68663479
32ketone body metabolic process (GO:1902224)5.65940967
33protein targeting to Golgi (GO:0000042)5.52699877
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.37972179
35germ cell development (GO:0007281)5.36872725
36establishment of protein localization to Golgi (GO:0072600)5.31400714
37retrograde transport, vesicle recycling within Golgi (GO:0000301)5.13587169
38cell recognition (GO:0008037)5.12986417
39regulation of microtubule-based movement (GO:0060632)5.11242361
40regulation of Rab GTPase activity (GO:0032313)5.05216464
41positive regulation of Rab GTPase activity (GO:0032851)5.05216464
42ventricular system development (GO:0021591)5.05014504
43chromosome condensation (GO:0030261)5.03311524
44spermatid nucleus differentiation (GO:0007289)4.91248809
45chromatin silencing (GO:0006342)4.83779164
46glycerol ether metabolic process (GO:0006662)4.83453346
47multicellular organismal reproductive process (GO:0048609)4.80476357
48DNA packaging (GO:0006323)4.79368469
49male meiosis I (GO:0007141)4.72350413
50microtubule severing (GO:0051013)4.57620852
51chromosome organization involved in meiosis (GO:0070192)4.49725320
52DNA methylation involved in gamete generation (GO:0043046)4.49561155
53centriole replication (GO:0007099)4.49385565
54ether metabolic process (GO:0018904)4.46775323
55regulation of transcription involved in cell fate commitment (GO:0060850)4.45886795
56seminiferous tubule development (GO:0072520)4.39637854
57left/right pattern formation (GO:0060972)4.33679561
58coenzyme catabolic process (GO:0009109)4.23059045
59chaperone-mediated protein complex assembly (GO:0051131)4.18676980
60meiotic nuclear division (GO:0007126)4.09917386
61protein localization to Golgi apparatus (GO:0034067)3.96978233
62multicellular organismal development (GO:0007275)3.87613814
63single strand break repair (GO:0000012)3.79247798
64meiosis I (GO:0007127)3.74904816
65regulation of centriole replication (GO:0046599)3.71403613
66negative regulation of Rho protein signal transduction (GO:0035024)3.70065385
67sexual reproduction (GO:0019953)3.69584047
68response to acidic pH (GO:0010447)3.64508080
69nucleosome disassembly (GO:0006337)3.60376149
70protein-DNA complex disassembly (GO:0032986)3.60376149
71microtubule polymerization or depolymerization (GO:0031109)3.54306580
72cellular response to pH (GO:0071467)3.53909000
73mesenchymal cell differentiation involved in kidney development (GO:0072161)3.46325331
74mesenchymal cell differentiation involved in renal system development (GO:2001012)3.46325331
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.40711369
76regulation of spindle checkpoint (GO:0090231)3.37594899
77protein polyglutamylation (GO:0018095)3.36199385
78genitalia morphogenesis (GO:0035112)3.34507374
79protein localization to cilium (GO:0061512)3.32403284
80multicellular organismal movement (GO:0050879)3.31012789
81musculoskeletal movement (GO:0050881)3.31012789
82membrane protein intracellular domain proteolysis (GO:0031293)3.30114232
83sequestering of actin monomers (GO:0042989)3.29581408
84negative regulation of gene expression, epigenetic (GO:0045814)3.29302253
85meiotic cell cycle (GO:0051321)3.26011277
86protein depolymerization (GO:0051261)3.25516178
87protein K11-linked deubiquitination (GO:0035871)3.24054085
88amino-acid betaine transport (GO:0015838)3.23739918
89carnitine transport (GO:0015879)3.23739918
90cerebral cortex neuron differentiation (GO:0021895)3.23712100
91NAD biosynthetic process (GO:0009435)3.19337494
92protein refolding (GO:0042026)3.19059658
93cell differentiation involved in metanephros development (GO:0072202)3.17292451
94regulation of interleukin-13 production (GO:0032656)3.16254357
95glomerular visceral epithelial cell development (GO:0072015)3.09868297
96polyol catabolic process (GO:0046174)3.09463383
97monoubiquitinated protein deubiquitination (GO:0035520)3.09437705
98cranial nerve morphogenesis (GO:0021602)3.05515917
99regulation of T-helper 2 cell differentiation (GO:0045628)3.05493240
100carnitine transmembrane transport (GO:1902603)3.05176274
101histone H3-K9 demethylation (GO:0033169)3.03397723
102glomerular epithelial cell development (GO:0072310)3.03343994
103interferon-gamma secretion (GO:0072643)3.01935172
104nucleus organization (GO:0006997)3.01776057
105homeostasis of number of cells within a tissue (GO:0048873)3.01248425
106alditol metabolic process (GO:0019400)2.99185543
107DNA conformation change (GO:0071103)2.94255968
108positive regulation of macrophage activation (GO:0043032)2.94168559
109glycolytic process (GO:0006096)2.94005493
110RNA localization (GO:0006403)2.93696173
111RNA destabilization (GO:0050779)2.92297475
112mitotic sister chromatid cohesion (GO:0007064)2.92126781
113negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.87821810
114nucleoside diphosphate phosphorylation (GO:0006165)2.86014706
115peptidyl-proline hydroxylation (GO:0019511)2.84392933
116cilium organization (GO:0044782)2.80771891
117tooth mineralization (GO:0034505)2.77479191
118positive regulation of skeletal muscle tissue development (GO:0048643)2.77211825
119cilium morphogenesis (GO:0060271)2.77019832
120microtubule-based movement (GO:0007018)2.72390021
121positive regulation of endothelial cell differentiation (GO:0045603)2.71717835
122cilium assembly (GO:0042384)2.71623438
123regulation of cilium assembly (GO:1902017)2.71447963
124regulation of somitogenesis (GO:0014807)2.70900284
125centriole assembly (GO:0098534)2.70465654
126polyamine biosynthetic process (GO:0006596)2.69189672
127cellular component assembly involved in morphogenesis (GO:0010927)2.67453457
128synapsis (GO:0007129)2.67093658
129axoneme assembly (GO:0035082)2.66835878
130meiotic cell cycle process (GO:1903046)2.63750771
131intraciliary transport (GO:0042073)2.61840276
132gene silencing by RNA (GO:0031047)2.55085063
133glycerol metabolic process (GO:0006071)2.52627403
134GTP biosynthetic process (GO:0006183)2.52201206
135peptidyl-glutamic acid modification (GO:0018200)2.51596832
136lactate metabolic process (GO:0006089)2.44485208
137negative regulation of organelle assembly (GO:1902116)2.43212364
138peptidyl-threonine dephosphorylation (GO:0035970)2.38823448
139fusion of sperm to egg plasma membrane (GO:0007342)14.1253839
140cell wall macromolecule metabolic process (GO:0044036)14.0124702
141cell wall macromolecule catabolic process (GO:0016998)14.0124702
142sperm motility (GO:0030317)13.5514956
143acrosome reaction (GO:0007340)12.3350315
144sperm-egg recognition (GO:0035036)11.7704043
145acrosome assembly (GO:0001675)11.4540880
146multicellular organism reproduction (GO:0032504)11.3640404
147plasma membrane fusion (GO:0045026)10.7656142
148cell-cell recognition (GO:0009988)10.5268585
149binding of sperm to zona pellucida (GO:0007339)10.4726743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.49044963
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.69587183
3EZH2_22144423_ChIP-Seq_EOC_Human3.86769103
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.73548210
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.72777284
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.62914992
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54047506
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12027983
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90705068
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.70946186
11VDR_22108803_ChIP-Seq_LS180_Human2.39421598
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18713194
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.13439497
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.09839234
15ZNF274_21170338_ChIP-Seq_K562_Hela2.05950351
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04783421
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00732893
18ERA_21632823_ChIP-Seq_H3396_Human1.99534937
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93775542
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.93282197
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92179156
22RAC3_21632823_ChIP-Seq_H3396_Human1.91626253
23CTCF_27219007_Chip-Seq_Bcells_Human1.89781421
24DROSHA_22980978_ChIP-Seq_HELA_Human1.89643098
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.87411912
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.87357332
27NANOG_20526341_ChIP-Seq_ESCs_Human1.85464692
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80765521
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79478068
30E2F1_20622854_ChIP-Seq_HELA_Human1.75838349
31BCL6_27268052_Chip-Seq_Bcells_Human1.75614972
32MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75401837
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74478871
34STAT1_17558387_ChIP-Seq_HELA_Human1.74438659
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72633716
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68854287
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66014350
38FUS_26573619_Chip-Seq_HEK293_Human1.64264258
39SMC4_20622854_ChIP-Seq_HELA_Human1.63457861
40P68_20966046_ChIP-Seq_HELA_Human1.63262405
41TAF2_19829295_ChIP-Seq_ESCs_Human1.62775237
42BCOR_27268052_Chip-Seq_Bcells_Human1.62417370
43PHF8_20622854_ChIP-Seq_HELA_Human1.62183993
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58809880
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.58186734
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56737415
47MYC_19829295_ChIP-Seq_ESCs_Human1.56498620
48GATA3_21867929_ChIP-Seq_CD8_Mouse1.55852557
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55703895
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55472074
51TP63_22573176_ChIP-Seq_HFKS_Human1.54847089
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54079543
53LXR_22292898_ChIP-Seq_THP-1_Human1.53902033
54KDM2B_26808549_Chip-Seq_REH_Human1.51078816
55OCT4_20526341_ChIP-Seq_ESCs_Human1.50053207
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49668482
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.49614854
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.48384421
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.47948881
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.45521470
61ER_23166858_ChIP-Seq_MCF-7_Human1.44732812
62P300_27268052_Chip-Seq_Bcells_Human1.42756021
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41924543
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41598607
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40828493
66CBP_20019798_ChIP-Seq_JUKART_Human1.39616338
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39616338
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39057233
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38828745
70LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37817473
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37243722
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37227753
73AR_25329375_ChIP-Seq_VCAP_Human1.37077619
74TP53_18474530_ChIP-ChIP_U2OS_Human1.34219235
75REST_21632747_ChIP-Seq_MESCs_Mouse1.32908968
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32712311
77P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.32552715
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.32287291
79P53_21459846_ChIP-Seq_SAOS-2_Human1.32116694
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.30424422
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29350716
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28694059
83CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28241489
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.28021190
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.26863557
86RBPJ_21746931_ChIP-Seq_IB4_Human1.26732698
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26195232
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.25554345
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25470325
90GF1_26923725_Chip-Seq_HPCs_Mouse1.24870739
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.24095350
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22847291
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21838550
94RUNX_20019798_ChIP-Seq_JUKART_Human1.20679683
95ETV1_20927104_ChIP-Seq_GIST48_Human1.20495787
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20154997
97RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19195235
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19145402
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17611146
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.17278891
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.16895565
102CEBPB_22108803_ChIP-Seq_LS180_Human1.16858508
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.15569198
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15173577
105SA1_27219007_Chip-Seq_Bcells_Human1.15091545
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14964451
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14345272
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.14101386
109SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13772444
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.13607666
111P300_19829295_ChIP-Seq_ESCs_Human1.13039049
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12159623
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11438677
114RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11283046
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10968756
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09965809
117SPI1_26923725_Chip-Seq_HPCs_Mouse1.09725753
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08850478
119SMRT_27268052_Chip-Seq_Bcells_Human1.07729233
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07715807
121TBL1_22424771_ChIP-Seq_293T_Human1.07684922
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07120412
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07082934
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06654783
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06412469
126CSB_26484114_Chip-Seq_FIBROBLAST_Human1.05043189
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.04946598
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03881336
129NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03847840
130GATA6_21074721_ChIP-Seq_CACO-2_Human1.03612510
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03408673
132ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03403760
133OCT1_27270436_Chip-Seq_PROSTATE_Human1.03350468
134PHF8_20622853_ChIP-Seq_HELA_Human1.03048044
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03028111
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03028111
137MYC_27129775_Chip-Seq_CORNEA_Mouse1.02786124
138SA1_27219007_Chip-Seq_ERYTHROID_Human1.02757147
139HOXB7_26014856_ChIP-Seq_BT474_Human1.01286832
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01195328
141GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00973888
142NANOG_19829295_ChIP-Seq_ESCs_Human1.00325734
143SOX2_19829295_ChIP-Seq_ESCs_Human1.00325734
144ESET_19884257_ChIP-Seq_ESCs_Mouse1.00004657
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.99945607
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.99331150
147JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99329572
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98491006
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.98407323
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98152081
151TET1_21451524_ChIP-Seq_MESCs_Mouse0.98148232
152TAF15_26573619_Chip-Seq_HEK293_Human0.97928035
153RUNX2_22187159_ChIP-Seq_PCA_Human0.97180200
154P53_22387025_ChIP-Seq_ESCs_Mouse0.95994015
155ERG_20517297_ChIP-Seq_VCAP_Human0.95683876
156E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95430737
157SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94927044
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.94164620
159NFYB_21822215_ChIP-Seq_K562_Human0.93959653
160CTCF_20526341_ChIP-Seq_ESCs_Human0.93375301
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.93279274
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93066370
163CMYC_18555785_Chip-Seq_ESCs_Mouse0.92187088
164KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91645297
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91486949
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91403249
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.91321256
168KLF4_18555785_Chip-Seq_ESCs_Mouse0.91277435
169EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91195281
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.90060033
171SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89022012
172STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88920448
173NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88800699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04546020
2MP0001929_abnormal_gametogenesis5.47639220
3MP0008877_abnormal_DNA_methylation3.96650014
4MP0001348_abnormal_lacrimal_gland3.41851497
5MP0002210_abnormal_sex_determination3.32142023
6MP0002161_abnormal_fertility/fecundity3.29431309
7MP0005670_abnormal_white_adipose3.05878036
8MP0001145_abnormal_male_reproductive2.82292707
9MP0000678_abnormal_parathyroid_gland2.69460975
10MP0000653_abnormal_sex_gland2.45776348
11MP0002653_abnormal_ependyma_morphology2.44780615
12MP0002132_abnormal_respiratory_system2.12174313
13MP0003718_maternal_effect2.06088824
14MP0005410_abnormal_fertilization16.5752587
15MP0004233_abnormal_muscle_weight1.78386728
16MP0002249_abnormal_larynx_morphology1.72522925
17MP0004510_myositis1.58207195
18MP0002160_abnormal_reproductive_system1.56795332
19MP0005379_endocrine/exocrine_gland_phen1.55745709
20MP0009053_abnormal_anal_canal1.54112713
21MP0003646_muscle_fatigue1.44813403
22MP0001486_abnormal_startle_reflex1.37331697
23MP0005623_abnormal_meninges_morphology1.35609581
24MP0001485_abnormal_pinna_reflex1.25176545
25MP0002735_abnormal_chemical_nociception1.23837761
26MP0002138_abnormal_hepatobiliary_system1.23369929
27MP0001984_abnormal_olfaction1.16761524
28MP0002282_abnormal_trachea_morphology1.16461963
29MP0005310_abnormal_salivary_gland1.15677329
30MP0002234_abnormal_pharynx_morphology1.15490721
31MP0004859_abnormal_synaptic_plasticity1.14283302
32MP0001765_abnormal_ion_homeostasis1.11525946
33MP0002127_abnormal_cardiovascular_syste1.09193336
34MP0002822_catalepsy1.06820945
35MP0001963_abnormal_hearing_physiology1.05322048
36MP0005248_abnormal_Harderian_gland1.02707704
37MP0000026_abnormal_inner_ear0.99321905
38MP0005647_abnormal_sex_gland0.92487133
39MP0005083_abnormal_biliary_tract0.92165225
40MP0005395_other_phenotype0.91730673
41MP0008995_early_reproductive_senescence0.89609227
42MP0000681_abnormal_thyroid_gland0.87768818
43MP0009046_muscle_twitch0.87490202
44MP0000049_abnormal_middle_ear0.86692624
45MP0000955_abnormal_spinal_cord0.80027088
46MP0002733_abnormal_thermal_nociception0.77313653
47MP0005389_reproductive_system_phenotype0.76761363
48MP0003115_abnormal_respiratory_system0.75371743
49MP0003011_delayed_dark_adaptation0.73647992
50MP0008058_abnormal_DNA_repair0.73507967
51MP0002067_abnormal_sensory_capabilities0.72199985
52MP0001879_abnormal_lymphatic_vessel0.70889847
53MP0003119_abnormal_digestive_system0.69593993
54MP0001666_abnormal_nutrient_absorption0.67930543
55MP0004085_abnormal_heartbeat0.67923262
56MP0003878_abnormal_ear_physiology0.66033819
57MP0005377_hearing/vestibular/ear_phenot0.66033819
58MP0002557_abnormal_social/conspecific_i0.65568679
59MP0002102_abnormal_ear_morphology0.64357275
60MP0000516_abnormal_urinary_system0.64218316
61MP0005367_renal/urinary_system_phenotyp0.64218316
62MP0000470_abnormal_stomach_morphology0.62012809
63MP0001905_abnormal_dopamine_level0.60630512
64MP0005636_abnormal_mineral_homeostasis0.59907362
65MP0005666_abnormal_adipose_tissue0.59240979
66MP0002572_abnormal_emotion/affect_behav0.56811044
67MP0003283_abnormal_digestive_organ0.56116814
68MP0003172_abnormal_lysosome_physiology0.54608907
69MP0001970_abnormal_pain_threshold0.52669905
70MP0005451_abnormal_body_composition0.52199730
71MP0002269_muscular_atrophy0.51792665
72MP0001324_abnormal_eye_pigmentation0.51133287
73MP0002272_abnormal_nervous_system0.50561887
74MP0002734_abnormal_mechanical_nocicepti0.50083067
75MP0005084_abnormal_gallbladder_morpholo0.49864742
76MP0006292_abnormal_olfactory_placode0.49860707
77MP0000003_abnormal_adipose_tissue0.48617029
78MP0004484_altered_response_of0.48325178
79MP0009697_abnormal_copulation0.47640831
80MP0001440_abnormal_grooming_behavior0.46595577
81MP0002928_abnormal_bile_duct0.45448938
82MP0005551_abnormal_eye_electrophysiolog0.45334537
83MP0003699_abnormal_female_reproductive0.45285962
84MP0005167_abnormal_blood-brain_barrier0.45177096
85MP0003329_amyloid_beta_deposits0.44617062
86MP0003880_abnormal_central_pattern0.44548262
87MP0000566_synostosis0.44160390
88MP0001764_abnormal_homeostasis0.43878257
89MP0009745_abnormal_behavioral_response0.43783859
90MP0001293_anophthalmia0.43126462
91MP0000358_abnormal_cell_content/0.42714348
92MP0001501_abnormal_sleep_pattern0.42125223
93MP0003137_abnormal_impulse_conducting0.40612533
94MP0001270_distended_abdomen0.39755717
95MP0000534_abnormal_ureter_morphology0.39727633
96MP0003950_abnormal_plasma_membrane0.39625223
97MP0004036_abnormal_muscle_relaxation0.39612670
98MP0000249_abnormal_blood_vessel0.39533903
99MP0005253_abnormal_eye_physiology0.39373911
100MP0010094_abnormal_chromosome_stability0.39304258
101MP0005408_hypopigmentation0.39048203
102MP0003077_abnormal_cell_cycle0.38757649
103MP0002736_abnormal_nociception_after0.38448759
104MP0003936_abnormal_reproductive_system0.37779215
105MP0006036_abnormal_mitochondrial_physio0.37340031
106MP0009115_abnormal_fat_cell0.37064661
107MP0000467_abnormal_esophagus_morphology0.35326424
108MP0009278_abnormal_bone_marrow0.35079449
109MP0003879_abnormal_hair_cell0.34283606
110MP0002971_abnormal_brown_adipose0.33980058
111MP0001661_extended_life_span0.33902648
112MP0000613_abnormal_salivary_gland0.33440675
113MP0005397_hematopoietic_system_phenotyp0.33338595
114MP0001545_abnormal_hematopoietic_system0.33338595
115MP0003942_abnormal_urinary_system0.30761611
116MP0005391_vision/eye_phenotype0.29964127
117MP0004811_abnormal_neuron_physiology0.29007007
118MP0004133_heterotaxia0.27912997
119MP0003633_abnormal_nervous_system0.26505043
120MP0001119_abnormal_female_reproductive0.26381608
121MP0008961_abnormal_basal_metabolism0.26337439
122MP0003111_abnormal_nucleus_morphology0.26292776
123MP0003786_premature_aging0.25771968
124MP0000569_abnormal_digit_pigmentation0.24700518
125MP0003861_abnormal_nervous_system0.24686502
126MP0002139_abnormal_hepatobiliary_system0.23602661
127MP0001968_abnormal_touch/_nociception0.23235270
128MP0002152_abnormal_brain_morphology0.23142721
129MP0004742_abnormal_vestibular_system0.21937928
130MP0004019_abnormal_vitamin_homeostasis0.21885539
131MP0000604_amyloidosis0.21026072
132MP0000462_abnormal_digestive_system0.20934823
133MP0003631_nervous_system_phenotype0.19925828
134MP0006035_abnormal_mitochondrial_morpho0.19852766
135MP0003948_abnormal_gas_homeostasis0.19740691
136MP0002295_abnormal_pulmonary_circulatio0.18757438
137MP0001730_embryonic_growth_arrest0.18477540
138MP0002169_no_abnormal_phenotype0.18440879
139MP0002873_normal_phenotype0.18190054
140MP0005535_abnormal_body_temperature0.17757010
141MP0003959_abnormal_lean_body0.17594954
142MP0005423_abnormal_somatic_nervous0.16263912
143MP0001849_ear_inflammation0.16139798
144MP0005365_abnormal_bile_salt0.15625434
145MP0001986_abnormal_taste_sensitivity0.15218138
146MP0002229_neurodegeneration0.15211409
147MP0002092_abnormal_eye_morphology0.15190090
148MP0004808_abnormal_hematopoietic_stem0.14415842
149MP0008875_abnormal_xenobiotic_pharmacok0.14359156
150MP0005375_adipose_tissue_phenotype0.13891439
151MP0005195_abnormal_posterior_eye0.13426830
152MP0008569_lethality_at_weaning0.13020035
153MP0010307_abnormal_tumor_latency0.12865637
154MP0005319_abnormal_enzyme/_coenzyme0.12813326
155MP0002118_abnormal_lipid_homeostasis0.12499855
156MP0000001_mammalian_phenotype0.12469300
157MP0002405_respiratory_system_inflammati0.12304965
158MP0005174_abnormal_tail_pigmentation0.12044456
159MP0000751_myopathy0.11904791
160MP0002752_abnormal_somatic_nervous0.11266332

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.40494838
2Abnormal respiratory epithelium morphology (HP:0012253)9.40494838
3Abnormal respiratory motile cilium physiology (HP:0012261)9.21401605
4Severe visual impairment (HP:0001141)8.92499165
5Rhinitis (HP:0012384)7.53768574
6Chronic bronchitis (HP:0004469)7.24052420
7Abnormal ciliary motility (HP:0012262)7.21405108
8Infertility (HP:0000789)6.87975242
9Nasal polyposis (HP:0100582)6.47625593
10Attenuation of retinal blood vessels (HP:0007843)5.55322696
11Bony spicule pigmentary retinopathy (HP:0007737)5.48674159
12Abnormality of the nasal mucosa (HP:0000433)5.33030563
13Male infertility (HP:0003251)4.60924210
14Abnormal rod and cone electroretinograms (HP:0008323)4.58658591
15Bronchitis (HP:0012387)4.57694019
16Bronchiectasis (HP:0002110)4.45299488
17Resting tremor (HP:0002322)4.44048716
18Hypoplastic ischia (HP:0003175)4.33532348
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.21114058
20Enlarged epiphyses (HP:0010580)4.19908491
21Hyperkalemia (HP:0002153)4.19251343
22Abnormality of macular pigmentation (HP:0008002)4.03924290
23Nephronophthisis (HP:0000090)3.99740969
24Facial shape deformation (HP:0011334)3.97926690
25Potter facies (HP:0002009)3.97926690
26Chronic hepatic failure (HP:0100626)3.88599380
27Abnormality of the ischium (HP:0003174)3.82371406
28Abnormal spermatogenesis (HP:0008669)3.69947203
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.54106395
30Unilateral renal agenesis (HP:0000122)3.47569265
31Cone-rod dystrophy (HP:0000548)3.45089150
32Recurrent otitis media (HP:0000403)3.26017157
33Recurrent sinusitis (HP:0011108)3.24337428
34Aplasia/Hypoplasia of the earlobes (HP:0009906)3.17177016
35Abnormality of the renal medulla (HP:0100957)3.01292429
36Impulsivity (HP:0100710)2.95032622
37Generalized aminoaciduria (HP:0002909)2.94611271
38Hypoplasia of the thymus (HP:0000778)2.89494508
39Abnormality of the aortic arch (HP:0012303)2.80982166
40Postural instability (HP:0002172)2.80654944
41Recurrent bronchitis (HP:0002837)2.80121751
42Medial flaring of the eyebrow (HP:0010747)2.76520481
43Tubulointerstitial nephritis (HP:0001970)2.69281064
44Progressive sensorineural hearing impairment (HP:0000408)2.68592731
45Flattened epiphyses (HP:0003071)2.61666487
46Epiphyseal dysplasia (HP:0002656)2.55204130
47Gonadotropin excess (HP:0000837)2.51809758
48Abnormality of potassium homeostasis (HP:0011042)2.47639015
49Tubular atrophy (HP:0000092)2.46652983
50Azoospermia (HP:0000027)2.45400772
51Abnormality of midbrain morphology (HP:0002418)2.41878373
52Molar tooth sign on MRI (HP:0002419)2.41878373
53Hypoalphalipoproteinemia (HP:0003233)2.37352261
54Cholecystitis (HP:0001082)2.36109429
55Abnormal gallbladder physiology (HP:0012438)2.36109429
56Abnormality of the epiphysis of the femoral head (HP:0010574)2.35554367
57Tubulointerstitial abnormality (HP:0001969)2.28983632
58Truncal obesity (HP:0001956)2.28259442
59Abnormality of the parathyroid morphology (HP:0011766)2.25874499
60Abnormality of the costochondral junction (HP:0000919)2.21719960
61Abnormality of the pubic bones (HP:0003172)2.21632138
62Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.20126991
63Abnormality of femoral epiphyses (HP:0006499)2.20126991
64Renovascular hypertension (HP:0100817)2.19005220
65Abnormality of dental color (HP:0011073)2.17704846
66Polyuria (HP:0000103)2.17443021
67Portal hypertension (HP:0001409)2.13915993
68Amelogenesis imperfecta (HP:0000705)2.13854596
69Progressive cerebellar ataxia (HP:0002073)2.12123618
70Abnormality of the femoral head (HP:0003368)2.10313645
71Insulin-resistant diabetes mellitus (HP:0000831)2.09475858
72Tetany (HP:0001281)2.09388387
73Flat capital femoral epiphysis (HP:0003370)2.08492011
74Dyschromatopsia (HP:0007641)2.04771478
75Spastic tetraparesis (HP:0001285)2.04387904
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03868271
77Osteomalacia (HP:0002749)2.03743667
78Ventricular tachycardia (HP:0004756)2.03604629
79Hyponatremia (HP:0002902)2.01942094
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.4628045
81Absent/shortened dynein arms (HP:0200106)13.4628045
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9270139
83Widely patent fontanelles and sutures (HP:0004492)1.98052149
84Choroideremia (HP:0001139)1.94491398
85Abnormality of the hepatic vasculature (HP:0006707)1.94193375
86Mixed hearing impairment (HP:0000410)1.90883345
87Optic nerve hypoplasia (HP:0000609)1.90811440
88Peripheral hypomyelination (HP:0007182)1.90753023
89Transposition of the great arteries (HP:0001669)1.88552654
90Abnormal connection of the cardiac segments (HP:0011545)1.88552654
91Abnormal ventriculo-arterial connection (HP:0011563)1.88552654
92Recurrent pneumonia (HP:0006532)1.88391153
93Decreased central vision (HP:0007663)1.87502257
94Focal segmental glomerulosclerosis (HP:0000097)1.87226295
95Heterotopia (HP:0002282)1.86830385
96Menstrual irregularities (HP:0000858)1.84664797
97Protuberant abdomen (HP:0001538)1.84312142
98Tubulointerstitial fibrosis (HP:0005576)1.83905227
99Pendular nystagmus (HP:0012043)1.82674353
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82567074
101Hyperthyroidism (HP:0000836)1.81934958
102Hypoparathyroidism (HP:0000829)1.78753241
103Congenital primary aphakia (HP:0007707)1.77944447
104Gait imbalance (HP:0002141)1.77943250
105Hypophosphatemic rickets (HP:0004912)1.76672749
106Aplasia/Hypoplasia of the lens (HP:0008063)1.76062848
107Postaxial foot polydactyly (HP:0001830)1.72663582
108Stage 5 chronic kidney disease (HP:0003774)1.69997531
109Polydipsia (HP:0001959)1.66900393
110Abnormal drinking behavior (HP:0030082)1.66900393
111Hemorrhage of the eye (HP:0011885)1.64838537
112Chronic sinusitis (HP:0011109)1.64552114
113Congenital hepatic fibrosis (HP:0002612)1.60267971
114Short ribs (HP:0000773)1.58191932
115Neurofibrillary tangles (HP:0002185)1.57231095
116Abnormality of renal excretion (HP:0011036)1.53888577
117Renal dysplasia (HP:0000110)1.51906748
118Abnormal biliary tract physiology (HP:0012439)1.51715445
119Bile duct proliferation (HP:0001408)1.51715445
120Nephrogenic diabetes insipidus (HP:0009806)1.50241745
121Easy fatigability (HP:0003388)1.50141682
122Abnormality of the renal cortex (HP:0011035)1.49311322
123Bell-shaped thorax (HP:0001591)1.49054341
124Postaxial hand polydactyly (HP:0001162)1.48975482
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.46991601
126Double outlet right ventricle (HP:0001719)1.46491422
127Congenital malformation of the right heart (HP:0011723)1.46491422
128Cerebellar dysplasia (HP:0007033)1.45594202
129Fatigable weakness (HP:0003473)1.43702407
130Abnormality of the neuromuscular junction (HP:0003398)1.43702407
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.43533791
132Absent epiphyses (HP:0010577)1.43533791
133Sensory axonal neuropathy (HP:0003390)1.42645042
134Facial cleft (HP:0002006)1.41806972
135Hemiparesis (HP:0001269)1.40030109
136Oculomotor apraxia (HP:0000657)1.39779987
137Vaginal atresia (HP:0000148)1.37949582
138Abnormality of permanent molar morphology (HP:0011071)1.37055391
139Abnormality of the dental root (HP:0006486)1.37055391
140Taurodontia (HP:0000679)1.37055391
141Asymmetric septal hypertrophy (HP:0001670)1.36339327
142Genital tract atresia (HP:0001827)1.33460047
143Fibular hypoplasia (HP:0003038)1.32311962
144Poor coordination (HP:0002370)1.31746381
145Bundle branch block (HP:0011710)1.31169977
146Abnormality of dentin (HP:0010299)1.30172490
147Cerebral inclusion bodies (HP:0100314)1.30172000
148Deformed sella turcica (HP:0002681)1.28457464
149Abnormality of saccadic eye movements (HP:0000570)1.27980999
150Abnormal urine output (HP:0012590)1.27347550
151Abnormality of molar morphology (HP:0011070)1.27172787
152Abnormality of molar (HP:0011077)1.27172787
153Abnormality of the dental pulp (HP:0006479)1.26985363
154Loss of speech (HP:0002371)1.26294778
155Retinal dysplasia (HP:0007973)1.26042126
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23886294
157Cystic liver disease (HP:0006706)1.21808735
158Abnormality of ocular smooth pursuit (HP:0000617)1.20901857
159Hypercholesterolemia (HP:0003124)1.20885810
160Type 2 muscle fiber atrophy (HP:0003554)1.18120574
161Supernumerary spleens (HP:0009799)1.17369365
162Short femoral neck (HP:0100864)1.16905520
163Type II lissencephaly (HP:0007260)1.15732185
164Generalized muscle weakness (HP:0003324)1.15494813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.72935206
2PDK47.72935206
3TESK16.78899379
4DDR25.74996434
5PRKD35.68722855
6PDK24.98402287
7ICK4.80880527
8INSRR4.48381930
9MAP4K24.37030251
10PLK22.56429751
11BRD42.40026756
12PTK2B2.18048893
13WNK42.10945144
14STK392.07024544
15MST1R1.99382820
16PNCK1.95024917
17STK381.92925519
18DYRK1B1.68378104
19NEK21.59863320
20MAP3K91.39263164
21CDK71.33934591
22PIK3CG1.33797699
23KSR21.20333302
24PDK11.18897336
25RPS6KA20.93383646
26TYRO30.93179859
27TESK20.89364004
28MAPK150.87892949
29UHMK10.85306278
30IRAK10.84567538
31DYRK30.84363076
32MAP3K110.84157966
33WNK10.83005487
34MAP3K20.78700677
35PASK0.76395394
36LATS20.76196330
37PDPK10.76063027
38CAMK1D0.73839883
39RIPK40.73664680
40MAP2K20.72178577
41PRKAA20.68037727
42CHEK20.67989220
43AKT30.67330747
44CCNB10.66850849
45STK30.66591923
46MAP3K80.66584659
47CAMK1G0.65860638
48ROCK10.60186271
49EEF2K0.58911350
50SIK20.57377169
51TTK0.55375212
52LMTK20.53809555
53RPS6KC10.52594641
54RPS6KL10.52594641
55MAP2K60.52509022
56PINK10.52267336
57RPS6KA60.51907975
58CDK30.51342220
59CAMK10.51183311
60PLK40.48090077
61MUSK0.45456790
62IRAK20.42844469
63PAK10.41923306
64STK38L0.41318624
65BMPR1B0.40676092
66NTRK20.39033400
67CHEK10.36725754
68CDK120.36711024
69ARAF0.36523229
70LATS10.36303148
71MAPK10.36137545
72SGK2230.33771173
73SGK4940.33771173
74CAMK40.33318412
75PRKCG0.33011093
76PAK20.32640876
77MET0.30849281
78MARK10.28075600
79ATM0.27080092
80MTOR0.27055270
81CAMKK10.26936187
82WEE10.26919503
83MAPKAPK50.26571240
84MARK20.26005816
85BRSK20.25280020
86PAK40.24140480
87NTRK30.24055543
88MAP3K100.23541932
89MAPK100.22355734
90MAPK140.22064455
91PKN10.21660717
92ATR0.21476353
93PRKAA10.20828884
94BLK0.20238442
95SGK10.19344535
96AKT10.18500821
97IKBKB0.17218673
98NEK60.17014485
99ABL20.16943430
100OXSR10.16623441
101PRKCZ0.15573298
102CDK150.14737554
103MAPK110.13566791
104MAP3K130.12899515
105CHUK0.12253045
106CDK180.11948518
107PRKCQ0.11946417
108MAP3K40.11885237
109BRSK10.11323313
110MAP3K70.11202413
111PLK10.10854984
112MINK10.10653599
113CDK11A0.10575264
114FER0.10451686
115RPS6KB10.09832116
116TIE10.09588662
117PRKACA0.08893681
118RPS6KA10.08651756
119PRKG20.08591597
120MARK30.08507131
121YES10.08455251
122BRAF0.07659378
123CDK60.07462163
124PRKG10.07226349
125CDK140.07204615
126MAPK90.07197256
127RIPK10.07163888
128FRK0.06278013
129ROCK20.06256549
130CSNK2A10.06122837
131GSK3B0.05746172
132CSNK1D0.05271186
133STK110.04987951
134CDC70.04855424
135PRKACG0.03447889
136CLK10.02989999
137CAMK2A0.02867336
138EGFR0.02759470
139CSF1R0.02443051
140STK100.02347368
141MAP3K10.01823565
142EPHB10.01805388
143PRKCB0.01371619
144CSNK2A20.01082696
145PRKCD0.00969465
146CDK40.00515900
147PRKCA0.00452385
148CDK20.00443014
149PAK6-0.0350661
150RPS6KA3-0.0338861
151AURKA-0.0330589
152MAP3K5-0.0278900
153ZAP70-0.0183609
154MAPK8-0.0041068
155CDK1-0.0039973
156PDGFRB-0.0030923
157PIM1-0.0020771

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.67949527
2Fatty acid biosynthesis_Homo sapiens_hsa000614.71910935
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34796736
4Olfactory transduction_Homo sapiens_hsa047403.43518187
5Vitamin B6 metabolism_Homo sapiens_hsa007503.36130892
6Pyruvate metabolism_Homo sapiens_hsa006203.32222590
7Butanoate metabolism_Homo sapiens_hsa006503.20980572
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.06187767
9Linoleic acid metabolism_Homo sapiens_hsa005912.97072655
10Propanoate metabolism_Homo sapiens_hsa006402.71280883
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.67027985
12Glucagon signaling pathway_Homo sapiens_hsa049222.51577579
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.41840137
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33121717
15Basal transcription factors_Homo sapiens_hsa030222.32146159
16Selenocompound metabolism_Homo sapiens_hsa004502.17126714
17Glycerolipid metabolism_Homo sapiens_hsa005612.07275432
18PPAR signaling pathway_Homo sapiens_hsa033201.99383503
19Allograft rejection_Homo sapiens_hsa053301.96386682
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94629494
21Type I diabetes mellitus_Homo sapiens_hsa049401.91581084
22Autoimmune thyroid disease_Homo sapiens_hsa053201.90065392
23Graft-versus-host disease_Homo sapiens_hsa053321.83213769
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69361379
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.68134852
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.66746828
27Pentose phosphate pathway_Homo sapiens_hsa000301.65673589
28Oocyte meiosis_Homo sapiens_hsa041141.62933971
29Fructose and mannose metabolism_Homo sapiens_hsa000511.59153802
30Dorso-ventral axis formation_Homo sapiens_hsa043201.58661240
31Type II diabetes mellitus_Homo sapiens_hsa049301.58651177
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57125869
33Mineral absorption_Homo sapiens_hsa049781.53103005
34Amphetamine addiction_Homo sapiens_hsa050311.52036551
35Phenylalanine metabolism_Homo sapiens_hsa003601.49577917
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46427491
37Fat digestion and absorption_Homo sapiens_hsa049751.43106686
38Fatty acid metabolism_Homo sapiens_hsa012121.41003156
39Ether lipid metabolism_Homo sapiens_hsa005651.39733826
40Fatty acid degradation_Homo sapiens_hsa000711.38618204
41Viral myocarditis_Homo sapiens_hsa054161.38318865
42Carbon metabolism_Homo sapiens_hsa012001.28768611
43Cardiac muscle contraction_Homo sapiens_hsa042601.28719055
44Arginine and proline metabolism_Homo sapiens_hsa003301.27596543
45Fanconi anemia pathway_Homo sapiens_hsa034601.26330166
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19328773
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14730050
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.09186766
49Renin secretion_Homo sapiens_hsa049241.06675813
50Antigen processing and presentation_Homo sapiens_hsa046121.05411398
51Huntingtons disease_Homo sapiens_hsa050161.03778981
52Collecting duct acid secretion_Homo sapiens_hsa049661.02778698
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.02168910
54Hedgehog signaling pathway_Homo sapiens_hsa043401.01175431
55Glutathione metabolism_Homo sapiens_hsa004801.00552675
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99878327
57Phototransduction_Homo sapiens_hsa047440.99738943
58Purine metabolism_Homo sapiens_hsa002300.98414216
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97907778
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93891274
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88935707
62mRNA surveillance pathway_Homo sapiens_hsa030150.87662866
63Arginine biosynthesis_Homo sapiens_hsa002200.84981078
64Morphine addiction_Homo sapiens_hsa050320.83336187
65Insulin secretion_Homo sapiens_hsa049110.82821782
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.81942378
67Chemical carcinogenesis_Homo sapiens_hsa052040.79961016
68RNA transport_Homo sapiens_hsa030130.79293712
69Arachidonic acid metabolism_Homo sapiens_hsa005900.75529575
70Influenza A_Homo sapiens_hsa051640.74136514
71Bile secretion_Homo sapiens_hsa049760.73635419
72Estrogen signaling pathway_Homo sapiens_hsa049150.72961831
73Biosynthesis of amino acids_Homo sapiens_hsa012300.72385271
74Long-term potentiation_Homo sapiens_hsa047200.71734800
75Thyroid hormone synthesis_Homo sapiens_hsa049180.69007090
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68028146
77Systemic lupus erythematosus_Homo sapiens_hsa053220.66959157
78Nicotine addiction_Homo sapiens_hsa050330.66811198
79Tyrosine metabolism_Homo sapiens_hsa003500.65392860
80Retinol metabolism_Homo sapiens_hsa008300.64575047
81Renin-angiotensin system_Homo sapiens_hsa046140.62324718
82ABC transporters_Homo sapiens_hsa020100.59800819
83Legionellosis_Homo sapiens_hsa051340.59649642
84Synaptic vesicle cycle_Homo sapiens_hsa047210.58191396
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56620076
86Protein digestion and absorption_Homo sapiens_hsa049740.55499167
87Pancreatic secretion_Homo sapiens_hsa049720.54165730
88Calcium signaling pathway_Homo sapiens_hsa040200.53745102
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.52026735
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50403755
91Salivary secretion_Homo sapiens_hsa049700.49935179
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48376797
93Inositol phosphate metabolism_Homo sapiens_hsa005620.45359064
94MAPK signaling pathway_Homo sapiens_hsa040100.44209828
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44058267
96Endocytosis_Homo sapiens_hsa041440.43802673
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.42563282
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42215140
99AMPK signaling pathway_Homo sapiens_hsa041520.41864244
100Glutamatergic synapse_Homo sapiens_hsa047240.41718774
101Gastric acid secretion_Homo sapiens_hsa049710.40495487
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40168286
103Taste transduction_Homo sapiens_hsa047420.39377688
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.39230188
105Tight junction_Homo sapiens_hsa045300.38844887
106Metabolic pathways_Homo sapiens_hsa011000.38605769
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38506083
108Cholinergic synapse_Homo sapiens_hsa047250.38146877
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37836886
110cAMP signaling pathway_Homo sapiens_hsa040240.37789517
111Nitrogen metabolism_Homo sapiens_hsa009100.37713148
112N-Glycan biosynthesis_Homo sapiens_hsa005100.36999983
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33789386
114Acute myeloid leukemia_Homo sapiens_hsa052210.33495486
115Serotonergic synapse_Homo sapiens_hsa047260.32555246
116Alcoholism_Homo sapiens_hsa050340.30348117
117VEGF signaling pathway_Homo sapiens_hsa043700.29475163
118Circadian entrainment_Homo sapiens_hsa047130.27979367
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27938254
120Viral carcinogenesis_Homo sapiens_hsa052030.27440435
121GABAergic synapse_Homo sapiens_hsa047270.24917837
122Cocaine addiction_Homo sapiens_hsa050300.24502383
123Oxytocin signaling pathway_Homo sapiens_hsa049210.24180873
124Pyrimidine metabolism_Homo sapiens_hsa002400.24136981
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.22496547
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.19330902
127Sulfur metabolism_Homo sapiens_hsa009200.18371344
128Basal cell carcinoma_Homo sapiens_hsa052170.18205235
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15878614
130Prolactin signaling pathway_Homo sapiens_hsa049170.15694032
131ECM-receptor interaction_Homo sapiens_hsa045120.15340599
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15100735
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14573547
134Herpes simplex infection_Homo sapiens_hsa051680.14192095
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14055816
136B cell receptor signaling pathway_Homo sapiens_hsa046620.13797954
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12004401
138Toxoplasmosis_Homo sapiens_hsa051450.11504938
139Wnt signaling pathway_Homo sapiens_hsa043100.10680372
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10191262
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07419749
142Salmonella infection_Homo sapiens_hsa051320.06467181
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06244116

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