CCDC187

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.59434354
2binding of sperm to zona pellucida (GO:0007339)9.55459326
3cell-cell recognition (GO:0009988)9.31128250
4epithelial cilium movement (GO:0003351)9.27056570
5spermatid development (GO:0007286)9.12784796
6axonemal dynein complex assembly (GO:0070286)8.97745855
7regulation of cilium movement (GO:0003352)8.95628537
8plasma membrane fusion (GO:0045026)8.91073005
9motile cilium assembly (GO:0044458)8.80891398
10cilium or flagellum-dependent cell motility (GO:0001539)8.34860716
11reproduction (GO:0000003)8.29888366
12cilium movement (GO:0003341)7.80222340
13negative regulation of inclusion body assembly (GO:0090084)7.12010160
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.81173287
15sperm capacitation (GO:0048240)6.67935039
16single fertilization (GO:0007338)6.60742840
17synaptonemal complex organization (GO:0070193)6.50505231
18organic cation transport (GO:0015695)6.42705142
19spermatogenesis (GO:0007283)6.38954086
20male gamete generation (GO:0048232)6.36317438
21synaptonemal complex assembly (GO:0007130)6.32208489
22male meiosis (GO:0007140)6.09263630
23piRNA metabolic process (GO:0034587)6.04425013
24left/right axis specification (GO:0070986)5.99422706
25calcium ion-dependent exocytosis (GO:0017156)5.93270243
26centriole assembly (GO:0098534)5.88093762
27gamete generation (GO:0007276)5.85272852
28microtubule bundle formation (GO:0001578)5.78821082
29fertilization (GO:0009566)5.78519739
30regulation of inclusion body assembly (GO:0090083)5.75801678
31microtubule depolymerization (GO:0007019)5.73007291
32regulation of microtubule-based movement (GO:0060632)5.31756145
33ventricular system development (GO:0021591)5.23576353
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.04534104
35germ cell development (GO:0007281)5.03821289
36phosphatidylethanolamine biosynthetic process (GO:0006646)5.01722698
37cell recognition (GO:0008037)4.84831017
38primary alcohol catabolic process (GO:0034310)4.81497754
39regulation of interleukin-13 production (GO:0032656)4.77762978
40multicellular organismal reproductive process (GO:0048609)4.65489194
41left/right pattern formation (GO:0060972)4.64979051
42regulation of interleukin-5 production (GO:0032674)4.63975717
43chromosome condensation (GO:0030261)4.62717308
44glomerular epithelial cell development (GO:0072310)4.61596635
45establishment of apical/basal cell polarity (GO:0035089)4.60515880
46microtubule severing (GO:0051013)4.58849199
47phosphatidylethanolamine metabolic process (GO:0046337)4.57201192
48lung epithelium development (GO:0060428)4.54724716
49ethanol metabolic process (GO:0006067)4.53917366
50DNA packaging (GO:0006323)4.51452459
51centriole replication (GO:0007099)4.45589307
52vitamin transmembrane transport (GO:0035461)4.44888235
53glycerol ether metabolic process (GO:0006662)4.19748950
54spermatid nucleus differentiation (GO:0007289)4.14628680
55one-carbon compound transport (GO:0019755)4.14505315
56seminiferous tubule development (GO:0072520)4.06457334
57male meiosis I (GO:0007141)4.05600282
58chromosome organization involved in meiosis (GO:0070192)3.99441652
59establishment or maintenance of monopolar cell polarity (GO:0061339)3.90309059
60establishment of monopolar cell polarity (GO:0061162)3.90309059
61protein polyglutamylation (GO:0018095)3.89010732
62ether metabolic process (GO:0018904)3.86298753
63sexual reproduction (GO:0019953)3.76477407
64DNA methylation involved in gamete generation (GO:0043046)3.74716729
65response to xenobiotic stimulus (GO:0009410)3.73396138
66multicellular organismal development (GO:0007275)3.72271639
67response to pheromone (GO:0019236)3.69965037
68diterpenoid biosynthetic process (GO:0016102)3.68513782
69cell projection assembly (GO:0030031)3.66814652
70negative regulation of T cell differentiation in thymus (GO:0033085)3.65152579
71RNA localization (GO:0006403)3.63442686
72ethanol oxidation (GO:0006069)3.52414300
73meiotic nuclear division (GO:0007126)3.47849806
74tolerance induction (GO:0002507)3.43913590
75sequestering of actin monomers (GO:0042989)3.36311270
76genitalia morphogenesis (GO:0035112)3.35592333
77chaperone-mediated protein complex assembly (GO:0051131)3.35074819
78lateral ventricle development (GO:0021670)3.32524848
79protein localization to cilium (GO:0061512)3.32371085
80protein K11-linked deubiquitination (GO:0035871)3.29695202
81establishment of tissue polarity (GO:0007164)3.24049090
82establishment of planar polarity (GO:0001736)3.24049090
83cytoplasmic microtubule organization (GO:0031122)3.20893905
84protein targeting to Golgi (GO:0000042)3.19688601
85establishment of protein localization to Golgi (GO:0072600)3.19420489
86pyrimidine-containing compound transmembrane transport (GO:0072531)3.19039393
87negative regulation of immunoglobulin mediated immune response (GO:0002890)3.16402386
88negative regulation of B cell mediated immunity (GO:0002713)3.16402386
89meiosis I (GO:0007127)3.15786199
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.14065932
91retrograde transport, vesicle recycling within Golgi (GO:0000301)3.13425773
92single strand break repair (GO:0000012)3.09188217
93positive regulation of Rab GTPase activity (GO:0032851)3.06816575
94regulation of Rab GTPase activity (GO:0032313)3.06816575
95negative regulation of humoral immune response (GO:0002921)3.05043692
96protein depolymerization (GO:0051261)3.04848463
97protein refolding (GO:0042026)3.00402532
98RNA destabilization (GO:0050779)3.00171350
99glycolytic process (GO:0006096)2.99331957
100interferon-gamma secretion (GO:0072643)2.95325803
101cellular ketone body metabolic process (GO:0046950)2.95257476
102microtubule-based movement (GO:0007018)2.94372483
103negative regulation of organelle assembly (GO:1902116)2.93590392
104regulation of protein kinase A signaling (GO:0010738)2.93437529
105axoneme assembly (GO:0035082)2.93154312
106cilium organization (GO:0044782)2.91991292
107regulation of spindle checkpoint (GO:0090231)2.91680848
108microtubule polymerization or depolymerization (GO:0031109)2.91257709
109intraciliary transport (GO:0042073)2.88533266
110cilium assembly (GO:0042384)2.84850505
111positive regulation of tolerance induction (GO:0002645)2.84645911
112calcium ion import (GO:0070509)2.82271953
113cellular response to pH (GO:0071467)2.80242765
114phosphatidylcholine biosynthetic process (GO:0006656)2.78054760
115regulation of cilium assembly (GO:1902017)2.77130692
116membrane depolarization during action potential (GO:0086010)2.77008630
117rRNA methylation (GO:0031167)2.76549883
118polyol catabolic process (GO:0046174)2.76008585
119cilium morphogenesis (GO:0060271)2.75451895
120nucleus organization (GO:0006997)2.73603744
121cellular component assembly involved in morphogenesis (GO:0010927)2.72393471
122spinal cord motor neuron differentiation (GO:0021522)2.71174426
123lactate metabolic process (GO:0006089)2.70654190
124musculoskeletal movement (GO:0050881)2.70359880
125multicellular organismal movement (GO:0050879)2.70359880
126meiotic cell cycle (GO:0051321)2.69721947
127carnitine transport (GO:0015879)2.68285441
128amino-acid betaine transport (GO:0015838)2.68285441
129regulation of transcription involved in cell fate commitment (GO:0060850)2.67770592
130positive regulation of smoothened signaling pathway (GO:0045880)2.67690487
131nucleosome disassembly (GO:0006337)2.67521446
132protein-DNA complex disassembly (GO:0032986)2.67521446
133regulation of germinal center formation (GO:0002634)2.66469644
134mitotic sister chromatid cohesion (GO:0007064)2.61553239
135carnitine transmembrane transport (GO:1902603)2.51581378
136nucleoside diphosphate phosphorylation (GO:0006165)2.50349404
137peptidyl-glutamic acid modification (GO:0018200)2.47913232
138polyamine biosynthetic process (GO:0006596)2.46622153
139regulation of protein kinase C signaling (GO:0090036)2.43648699
140negative regulation of skeletal muscle tissue development (GO:0048642)2.42393799
141regulation of acrosome reaction (GO:0060046)2.41970690
142positive regulation of macrophage activation (GO:0043032)2.41110570
143regulation of chromatin binding (GO:0035561)2.41094803
144sperm motility (GO:0030317)13.4366687
145acrosome reaction (GO:0007340)12.1580864
146fusion of sperm to egg plasma membrane (GO:0007342)11.6325272
147cell wall macromolecule metabolic process (GO:0044036)10.9824379
148cell wall macromolecule catabolic process (GO:0016998)10.9824379
149sperm-egg recognition (GO:0035036)10.4402761
150acrosome assembly (GO:0001675)10.0053814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.84057846
2EZH2_22144423_ChIP-Seq_EOC_Human5.49231606
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.25052073
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.51351180
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23915003
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70583227
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.66317614
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35845730
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.22468786
10SMC4_20622854_ChIP-Seq_HELA_Human2.21607759
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13774481
12ELF1_20517297_ChIP-Seq_JURKAT_Human1.94508257
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92700841
14ZNF274_21170338_ChIP-Seq_K562_Hela1.85990674
15REST_21632747_ChIP-Seq_MESCs_Mouse1.80418609
16ARNT_22903824_ChIP-Seq_MCF-7_Human1.80343755
17TP63_22573176_ChIP-Seq_HFKS_Human1.77342598
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76866094
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76177642
20TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74576811
21RUNX1_27514584_Chip-Seq_MCF-7_Human1.74436457
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71992831
23P68_20966046_ChIP-Seq_HELA_Human1.71123433
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70223841
25LXR_22292898_ChIP-Seq_THP-1_Human1.68545196
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62203064
27TAF15_26573619_Chip-Seq_HEK293_Human1.60084001
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59711243
29VDR_22108803_ChIP-Seq_LS180_Human1.58008504
30AHR_22903824_ChIP-Seq_MCF-7_Human1.57465534
31PHF8_20622854_ChIP-Seq_HELA_Human1.57361638
32SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.55760858
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54706187
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52660172
35KLF5_25053715_ChIP-Seq_YYC3_Human1.52262430
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52091732
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51725419
38E2F1_20622854_ChIP-Seq_HELA_Human1.50711454
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50233770
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.49036613
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.45890171
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44725978
43STAT1_17558387_ChIP-Seq_HELA_Human1.44301703
44FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43780233
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41790670
46STAT1_20625510_ChIP-Seq_HELA_Human1.41151999
47BCOR_27268052_Chip-Seq_Bcells_Human1.41003010
48KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40051316
49BCL6_27268052_Chip-Seq_Bcells_Human1.39098217
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38733835
51P300_27268052_Chip-Seq_Bcells_Human1.38514787
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35941342
53CBP_20019798_ChIP-Seq_JUKART_Human1.35941342
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34862544
55ERA_21632823_ChIP-Seq_H3396_Human1.34500068
56TP53_18474530_ChIP-ChIP_U2OS_Human1.31937108
57KDM2B_26808549_Chip-Seq_REH_Human1.31469610
58SMRT_27268052_Chip-Seq_Bcells_Human1.30898318
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30673046
60HNFA_21074721_ChIP-Seq_CACO-2_Human1.29970872
61OCT4_20526341_ChIP-Seq_ESCs_Human1.29880022
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29423250
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29083079
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.29067163
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28912443
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28886520
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.28262843
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.28207409
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27964739
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27762068
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27427975
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27427975
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.27066514
74PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26362012
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25794016
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23992185
77TP63_23658742_ChIP-Seq_EP156T_Human1.23627055
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22753767
79CEBPB_22108803_ChIP-Seq_LS180_Human1.22233382
80GF1_26923725_Chip-Seq_HPCs_Mouse1.21867015
81DROSHA_22980978_ChIP-Seq_HELA_Human1.21762283
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20065760
83RBPJ_21746931_ChIP-Seq_IB4_Human1.19957049
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.19426589
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18457559
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18430236
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.18268970
88CBX2_22325352_ChIP-Seq_293T-Rex_Human1.17798855
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17568069
90MYC_19829295_ChIP-Seq_ESCs_Human1.17464440
91MYC_27129775_Chip-Seq_CORNEA_Mouse1.17254783
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17063985
93FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17052209
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16685685
95GATA1_19941826_ChIP-Seq_K562_Human1.16509274
96PHF8_20622853_ChIP-Seq_HELA_Human1.15544558
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14833478
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14770003
99LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.14634068
100AR_21572438_ChIP-Seq_LNCaP_Human1.13401479
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.12594741
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12371909
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11413726
104NANOG_20526341_ChIP-Seq_ESCs_Human1.10382901
105NFYB_21822215_ChIP-Seq_K562_Human1.08843786
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.08823995
107RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08508777
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.07581001
109PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07460984
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07232427
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06357017
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05956708
113SMAD3_21741376_ChIP-Seq_ESCs_Human1.05886836
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.05516862
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05387388
116NFYA_21822215_ChIP-Seq_K562_Human1.04999898
117GATA6_21074721_ChIP-Seq_CACO-2_Human1.04207571
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.03436007
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03356829
120SA1_27219007_Chip-Seq_Bcells_Human1.03115601
121P53_21459846_ChIP-Seq_SAOS-2_Human1.02652966
122CTCF_27219007_Chip-Seq_Bcells_Human1.02596595
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02160076
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.02019007
125SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01124436
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00062948
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99713682
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.99594979
129RAC3_21632823_ChIP-Seq_H3396_Human0.99033279
130OCT4_19829295_ChIP-Seq_ESCs_Human0.98943967
131SOX9_26525672_Chip-Seq_HEART_Mouse0.98487616
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98108510
133TAF2_19829295_ChIP-Seq_ESCs_Human0.98089817
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.98062422
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.97400529
136GATA3_21867929_ChIP-Seq_TH1_Mouse0.95703252
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95625882
138ER_23166858_ChIP-Seq_MCF-7_Human0.95395320
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95203542
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94658810
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94022204
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93976638
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.93366439
144CTCF_20526341_ChIP-Seq_ESCs_Human0.93085603
145RNF2_27304074_Chip-Seq_NSC_Mouse0.92717523
146JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92313658
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92141410
148GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91205803
149TBL1_22424771_ChIP-Seq_293T_Human0.90133978
150ERG_20517297_ChIP-Seq_VCAP_Human0.89136822
151OCT1_27270436_Chip-Seq_PROSTATE_Human0.88889807
152SMAD4_21799915_ChIP-Seq_A2780_Human0.88759690
153RNF2_27304074_Chip-Seq_ESCs_Mouse0.87728256
154P53_22387025_ChIP-Seq_ESCs_Mouse0.86776448
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86378352
156KLF4_19829295_ChIP-Seq_ESCs_Human0.86189996
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.85928088
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85582794
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85351565
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85319975
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84581370
162TET1_21451524_ChIP-Seq_MESCs_Mouse0.83999599
163ETV1_20927104_ChIP-Seq_GIST48_Human0.83475173
164SPI1_26923725_Chip-Seq_HPCs_Mouse0.83273362
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82802415
166TCF4_23295773_ChIP-Seq_U87_Human0.82587604
167OCT4_18555785_Chip-Seq_ESCs_Mouse0.81754704
168CMYC_18555785_Chip-Seq_ESCs_Mouse0.81687699
169EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81548163
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.81440485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.45201868
2MP0002132_abnormal_respiratory_system4.84444775
3MP0001929_abnormal_gametogenesis4.74741757
4MP0008877_abnormal_DNA_methylation3.61603029
5MP0005670_abnormal_white_adipose3.00066552
6MP0002161_abnormal_fertility/fecundity2.97034837
7MP0002210_abnormal_sex_determination2.78293096
8MP0000678_abnormal_parathyroid_gland2.77631119
9MP0002249_abnormal_larynx_morphology2.58181640
10MP0002822_catalepsy2.52126426
11MP0001145_abnormal_male_reproductive2.35883317
12MP0009780_abnormal_chondrocyte_physiolo2.34838045
13MP0001348_abnormal_lacrimal_gland2.09157522
14MP0000653_abnormal_sex_gland2.05092709
15MP0005410_abnormal_fertilization15.1907895
16MP0002653_abnormal_ependyma_morphology1.96961253
17MP0002277_abnormal_respiratory_mucosa1.93548427
18MP0001485_abnormal_pinna_reflex1.84411504
19MP0000681_abnormal_thyroid_gland1.71737820
20MP0002168_other_aberrant_phenotype1.69486556
21MP0002160_abnormal_reproductive_system1.65873643
22MP0001984_abnormal_olfaction1.61935672
23MP0002735_abnormal_chemical_nociception1.60365819
24MP0000566_synostosis1.52608212
25MP0004859_abnormal_synaptic_plasticity1.50144314
26MP0005395_other_phenotype1.50045702
27MP0005083_abnormal_biliary_tract1.41956941
28MP0000383_abnormal_hair_follicle1.37153345
29MP0009046_muscle_twitch1.32690102
30MP0005394_taste/olfaction_phenotype1.31490136
31MP0005499_abnormal_olfactory_system1.31490136
32MP0004270_analgesia1.29869543
33MP0005623_abnormal_meninges_morphology1.27628105
34MP0003718_maternal_effect1.25884131
35MP0004233_abnormal_muscle_weight1.24668245
36MP0008789_abnormal_olfactory_epithelium1.23221192
37MP0003635_abnormal_synaptic_transmissio1.21165660
38MP0003787_abnormal_imprinting1.16829250
39MP0005310_abnormal_salivary_gland1.13600292
40MP0002063_abnormal_learning/memory/cond1.10913264
41MP0004019_abnormal_vitamin_homeostasis1.09993493
42MP0003646_muscle_fatigue1.08715309
43MP0002909_abnormal_adrenal_gland1.08379272
44MP0002234_abnormal_pharynx_morphology1.07826872
45MP0010678_abnormal_skin_adnexa1.06923459
46MP0010030_abnormal_orbit_morphology1.06710177
47MP0001765_abnormal_ion_homeostasis1.02971584
48MP0005248_abnormal_Harderian_gland1.01772450
49MP0009745_abnormal_behavioral_response1.01707513
50MP0000026_abnormal_inner_ear1.00496686
51MP0001963_abnormal_hearing_physiology0.99780176
52MP0005646_abnormal_pituitary_gland0.99345534
53MP0002282_abnormal_trachea_morphology0.97950171
54MP0003880_abnormal_central_pattern0.97086052
55MP0005423_abnormal_somatic_nervous0.93630451
56MP0002272_abnormal_nervous_system0.91975382
57MP0002572_abnormal_emotion/affect_behav0.90742288
58MP0000534_abnormal_ureter_morphology0.89114042
59MP0005645_abnormal_hypothalamus_physiol0.84571605
60MP0003656_abnormal_erythrocyte_physiolo0.84088745
61MP0004811_abnormal_neuron_physiology0.83928072
62MP0005551_abnormal_eye_electrophysiolog0.80418316
63MP0001486_abnormal_startle_reflex0.78610475
64MP0009053_abnormal_anal_canal0.76173828
65MP0008995_early_reproductive_senescence0.75111850
66MP0002557_abnormal_social/conspecific_i0.74805760
67MP0002064_seizures0.73960149
68MP0005389_reproductive_system_phenotype0.73118155
69MP0003115_abnormal_respiratory_system0.71053833
70MP0008569_lethality_at_weaning0.67221040
71MP0001944_abnormal_pancreas_morphology0.67162398
72MP0001968_abnormal_touch/_nociception0.67050639
73MP0000955_abnormal_spinal_cord0.66846198
74MP0001970_abnormal_pain_threshold0.66698942
75MP0003045_fibrosis0.66682053
76MP0003633_abnormal_nervous_system0.65084429
77MP0003879_abnormal_hair_cell0.64076956
78MP0002136_abnormal_kidney_physiology0.63259700
79MP0008872_abnormal_physiological_respon0.61886273
80MP0005220_abnormal_exocrine_pancreas0.61226596
81MP0001666_abnormal_nutrient_absorption0.61068089
82MP0001529_abnormal_vocalization0.60602986
83MP0002152_abnormal_brain_morphology0.59816755
84MP0002928_abnormal_bile_duct0.58962145
85MP0003329_amyloid_beta_deposits0.58320250
86MP0005666_abnormal_adipose_tissue0.57568154
87MP0001346_abnormal_lacrimal_gland0.57324188
88MP0005377_hearing/vestibular/ear_phenot0.56910592
89MP0003878_abnormal_ear_physiology0.56910592
90MP0001324_abnormal_eye_pigmentation0.56387656
91MP0001849_ear_inflammation0.55539676
92MP0001501_abnormal_sleep_pattern0.55108291
93MP0005253_abnormal_eye_physiology0.55014266
94MP0001879_abnormal_lymphatic_vessel0.53629697
95MP0009643_abnormal_urine_homeostasis0.53505515
96MP0008961_abnormal_basal_metabolism0.53489664
97MP0000569_abnormal_digit_pigmentation0.52886044
98MP0005375_adipose_tissue_phenotype0.51472414
99MP0001177_atelectasis0.51204156
100MP0003861_abnormal_nervous_system0.51155098
101MP0002733_abnormal_thermal_nociception0.51140689
102MP0000049_abnormal_middle_ear0.50080621
103MP0002882_abnormal_neuron_morphology0.50024977
104MP0001905_abnormal_dopamine_level0.49816169
105MP0001188_hyperpigmentation0.49496051
106MP0002734_abnormal_mechanical_nocicepti0.49352399
107MP0002736_abnormal_nociception_after0.48454480
108MP0003942_abnormal_urinary_system0.46735433
109MP0000467_abnormal_esophagus_morphology0.46620163
110MP0003283_abnormal_digestive_organ0.45989686
111MP0001440_abnormal_grooming_behavior0.45739068
112MP0001293_anophthalmia0.45689949
113MP0009765_abnormal_xenobiotic_induced0.44999703
114MP0001502_abnormal_circadian_rhythm0.44558858
115MP0004264_abnormal_extraembryonic_tissu0.44343588
116MP0003631_nervous_system_phenotype0.43547617
117MP0005647_abnormal_sex_gland0.43367758
118MP0005164_abnormal_response_to0.43011550
119MP0002098_abnormal_vibrissa_morphology0.41934863
120MP0004133_heterotaxia0.41382189
121MP0000631_abnormal_neuroendocrine_gland0.40530688
122MP0000470_abnormal_stomach_morphology0.39295745
123MP0002066_abnormal_motor_capabilities/c0.39239322
124MP0004085_abnormal_heartbeat0.39109141
125MP0000778_abnormal_nervous_system0.39019269
126MP0003699_abnormal_female_reproductive0.38684724
127MP0003890_abnormal_embryonic-extraembry0.37931789
128MP0002067_abnormal_sensory_capabilities0.37898394
129MP0003948_abnormal_gas_homeostasis0.37744025
130MP0009115_abnormal_fat_cell0.37606475
131MP0005636_abnormal_mineral_homeostasis0.36681933
132MP0000003_abnormal_adipose_tissue0.36534919
133MP0002295_abnormal_pulmonary_circulatio0.36510813
134MP0009278_abnormal_bone_marrow0.36243228
135MP0005409_darkened_coat_color0.36013902
136MP0002229_neurodegeneration0.35852648
137MP0002876_abnormal_thyroid_physiology0.35767463
138MP0005391_vision/eye_phenotype0.34462549
139MP0005167_abnormal_blood-brain_barrier0.33691046
140MP0008875_abnormal_xenobiotic_pharmacok0.33652072
141MP0004043_abnormal_pH_regulation0.33393080
142MP0004742_abnormal_vestibular_system0.33024349
143MP0002133_abnormal_respiratory_system0.32194906
144MP0005388_respiratory_system_phenotype0.32194906
145MP0006072_abnormal_retinal_apoptosis0.32128457
146MP0004885_abnormal_endolymph0.31677847
147MP0002184_abnormal_innervation0.31414689
148MP0001270_distended_abdomen0.31276752

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.71466614
2Abnormal respiratory motile cilium morphology (HP:0005938)8.71466614
3Abnormal respiratory motile cilium physiology (HP:0012261)8.57362683
4Rhinitis (HP:0012384)6.93580373
5Chronic bronchitis (HP:0004469)6.83813387
6Abnormal ciliary motility (HP:0012262)6.81671795
7Infertility (HP:0000789)6.80744818
8Nasal polyposis (HP:0100582)5.37259326
9Male infertility (HP:0003251)5.33627773
10Nephronophthisis (HP:0000090)4.45288041
11Abnormality of the nasal mucosa (HP:0000433)4.43948036
12Bronchitis (HP:0012387)4.12896817
13Bronchiectasis (HP:0002110)4.09568062
14Chronic hepatic failure (HP:0100626)3.51731598
15Abnormality of the renal medulla (HP:0100957)3.30469621
16Occipital encephalocele (HP:0002085)3.20788113
17Atelectasis (HP:0100750)3.19666083
18Abnormal spermatogenesis (HP:0008669)3.18806082
19Recurrent otitis media (HP:0000403)2.90076053
20Hyperactive renin-angiotensin system (HP:0000841)2.88086139
21Abnormality of midbrain morphology (HP:0002418)2.75029478
22Molar tooth sign on MRI (HP:0002419)2.75029478
23Choroideremia (HP:0001139)2.57786306
24Abnormal gallbladder physiology (HP:0012438)2.54242553
25Cholecystitis (HP:0001082)2.54242553
26Recurrent sinusitis (HP:0011108)2.53431606
27Severe visual impairment (HP:0001141)2.52690750
28Tubulointerstitial nephritis (HP:0001970)2.50777219
29Spastic tetraparesis (HP:0001285)2.42106301
30Decreased central vision (HP:0007663)2.39774534
31Dyschromatopsia (HP:0007641)2.39537012
32Medial flaring of the eyebrow (HP:0010747)2.36586442
33Impulsivity (HP:0100710)2.33522487
34Chronic otitis media (HP:0000389)2.32453431
35Recurrent bronchitis (HP:0002837)2.32285771
36Tubular atrophy (HP:0000092)2.32018051
37Pancreatic cysts (HP:0001737)2.25867207
38Tubulointerstitial abnormality (HP:0001969)2.19748624
39Cone-rod dystrophy (HP:0000548)2.07638732
40Gonadotropin excess (HP:0000837)2.06091139
41Dynein arm defect of respiratory motile cilia (HP:0012255)12.3917074
42Absent/shortened dynein arms (HP:0200106)12.3917074
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5428575
44Azoospermia (HP:0000027)1.97842165
45Hemorrhage of the eye (HP:0011885)1.88406622
46Heterotopia (HP:0002282)1.85856121
47Stage 5 chronic kidney disease (HP:0003774)1.85565358
48Tubulointerstitial fibrosis (HP:0005576)1.85492402
49Polydipsia (HP:0001959)1.82436378
50Abnormal drinking behavior (HP:0030082)1.82436378
51Bell-shaped thorax (HP:0001591)1.78170009
52Anencephaly (HP:0002323)1.77691247
53Hemiparesis (HP:0001269)1.75320748
54Abnormality of renal excretion (HP:0011036)1.74027642
55Bony spicule pigmentary retinopathy (HP:0007737)1.73269273
56Abnormality of chloride homeostasis (HP:0011422)1.72167740
57Abnormality of the lower motor neuron (HP:0002366)1.71946474
58Postaxial foot polydactyly (HP:0001830)1.71382396
59Neurofibrillary tangles (HP:0002185)1.70921695
60Renal salt wasting (HP:0000127)1.70355183
61Myokymia (HP:0002411)1.68340580
62Abnormality of dentin (HP:0010299)1.67383423
63Abnormality of permanent molar morphology (HP:0011071)1.67124152
64Abnormality of the dental root (HP:0006486)1.67124152
65Taurodontia (HP:0000679)1.67124152
66Abnormality of macular pigmentation (HP:0008002)1.66739647
67Decreased circulating renin level (HP:0003351)1.64719489
68Sclerocornea (HP:0000647)1.63798745
69Oculomotor apraxia (HP:0000657)1.63458179
70Abnormal rod and cone electroretinograms (HP:0008323)1.63195893
71Bundle branch block (HP:0011710)1.60531609
72Median cleft lip (HP:0000161)1.59126134
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.58576976
74Bile duct proliferation (HP:0001408)1.58251624
75Abnormal biliary tract physiology (HP:0012439)1.58251624
76Hyponatremia (HP:0002902)1.57924281
77Congenital hepatic fibrosis (HP:0002612)1.56293476
78Hyperkalemia (HP:0002153)1.55508597
79Postaxial hand polydactyly (HP:0001162)1.55246732
80Abnormality of molar (HP:0011077)1.54517953
81Abnormality of molar morphology (HP:0011070)1.54517953
82Broad distal phalanx of finger (HP:0009836)1.54452668
83Hyperaldosteronism (HP:0000859)1.54039125
84Abnormality of the dental pulp (HP:0006479)1.51776266
85Aplasia/Hypoplasia of the lens (HP:0008063)1.51726084
86Male pseudohermaphroditism (HP:0000037)1.51418847
87Abnormal urine output (HP:0012590)1.50811064
88Short ribs (HP:0000773)1.50015746
89Renal dysplasia (HP:0000110)1.48807410
90Progressive sensorineural hearing impairment (HP:0000408)1.47574099
91Absent frontal sinuses (HP:0002688)1.45601707
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44307211
93Neoplasm of the heart (HP:0100544)1.43674458
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.42678481
95Short nail (HP:0001799)1.42573275
96Cerebral inclusion bodies (HP:0100314)1.40562247
97Impaired vibration sensation in the lower limbs (HP:0002166)1.39866395
98Abnormality of the renal cortex (HP:0011035)1.39422628
99Abnormality of saccadic eye movements (HP:0000570)1.39257138
100Cystic liver disease (HP:0006706)1.38943823
101Nephropathy (HP:0000112)1.37545505
102Gait imbalance (HP:0002141)1.36227395
103Genetic anticipation (HP:0003743)1.35520053
104Exercise-induced myalgia (HP:0003738)1.34849393
105Abnormality of renin-angiotensin system (HP:0000847)1.33356062
106Asymmetric septal hypertrophy (HP:0001670)1.33197688
107Pancreatic fibrosis (HP:0100732)1.33086508
108Portal hypertension (HP:0001409)1.32916675
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.32889044
110Abnormality of ocular smooth pursuit (HP:0000617)1.32188657
111Congenital primary aphakia (HP:0007707)1.32181851
112Deformed sella turcica (HP:0002681)1.30429230
113Ankle clonus (HP:0011448)1.28715103
114Polyuria (HP:0000103)1.27552097
115Progressive cerebellar ataxia (HP:0002073)1.27278686
116Hand muscle atrophy (HP:0009130)1.25903230
117True hermaphroditism (HP:0010459)1.25585063
118Vascular calcification (HP:0004934)1.25170482
119Fibular hypoplasia (HP:0003038)1.24876154
120Chronic sinusitis (HP:0011109)1.24233289
121Supranuclear gaze palsy (HP:0000605)1.23806780
122EMG: neuropathic changes (HP:0003445)1.23595602
123Congenital malformation of the right heart (HP:0011723)1.23020782
124Double outlet right ventricle (HP:0001719)1.23020782
125Nephrogenic diabetes insipidus (HP:0009806)1.23004357
126Facial cleft (HP:0002006)1.22923647
127Abnormality of the hepatic vasculature (HP:0006707)1.20534763
128Recurrent pneumonia (HP:0006532)1.20462184
129Short thorax (HP:0010306)1.20337257
130Obstructive sleep apnea (HP:0002870)1.19829332
131Abnormality of potassium homeostasis (HP:0011042)1.19647599
132Glucose intolerance (HP:0000833)1.17484387
133Truncal obesity (HP:0001956)1.17402811
134Fetal akinesia sequence (HP:0001989)1.17236313
135Abnormality of sodium homeostasis (HP:0010931)1.15727843
136Hypoplastic ischia (HP:0003175)1.14594281
137Asplenia (HP:0001746)1.14452330
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.14449552
139Polycystic kidney dysplasia (HP:0000113)1.13486865
140Lip pit (HP:0100267)1.11720019
141Down-sloping shoulders (HP:0200021)1.11567367
142Menstrual irregularities (HP:0000858)1.10818300
143Preaxial hand polydactyly (HP:0001177)1.10571307
144Furrowed tongue (HP:0000221)1.10444267
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.09863685
146Epiphyseal dysplasia (HP:0002656)1.09571461
147Self-mutilation (HP:0000742)1.09439321
148Insulin-resistant diabetes mellitus (HP:0000831)1.08829397
149Postural instability (HP:0002172)1.08827939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.91608877
2TESK16.90148414
3PDK46.49875857
4PDK36.49875857
5PRKD36.34498531
6ICK4.66119989
7PDK24.50580855
8PLK43.86175466
9EPHA23.38132135
10MST43.09230234
11STK382.47731285
12MST1R2.45070651
13PTK2B2.38064421
14DDR21.95249919
15STK391.87330620
16WNK41.82260679
17PNCK1.74105230
18DYRK1B1.66451039
19NME11.57800273
20CDK121.49662739
21EPHA41.49266305
22BRD41.41835091
23WNK11.30799028
24TYRO31.29536009
25PDK11.24778629
26SMG11.24759350
27TRIB31.21476938
28NEK21.14459956
29LMTK21.12725338
30NTRK21.03737728
31RIPK11.02564690
32RIPK40.99141033
33PDPK10.97623666
34MAP3K70.95828955
35MAPK150.95307384
36MAPKAPK30.88474002
37PLK20.83843530
38MAP4K20.83610569
39CSK0.80592869
40TAOK10.76980022
41MARK20.74331419
42CAMKK10.72866014
43TESK20.71735867
44CAMK1G0.67185596
45MAP3K40.65506362
46PRKAA20.63393354
47CAMK1D0.63154059
48PINK10.62035739
49NTRK30.60297308
50FRK0.60199544
51EEF2K0.59987013
52LATS10.58185712
53MAP3K20.57841180
54GRK10.57126046
55MARK10.57035145
56NEK60.52901076
57SGK10.50716734
58TLK10.50277674
59STK38L0.49631399
60MAP2K20.49584781
61PRKCG0.49208789
62MINK10.48512521
63MET0.48188048
64IRAK20.48147830
65TRPM70.47847739
66MAP2K70.46354163
67STK100.46232666
68MAPKAPK50.45685636
69ERBB20.44906952
70STK240.43863642
71CDK70.43578247
72DAPK20.42104354
73MAP3K100.40735569
74PAK60.38491015
75EPHB10.37906629
76TTK0.37757524
77IRAK10.36119708
78DYRK30.35827040
79MTOR0.34411616
80PAK10.34165298
81PRKCZ0.33468117
82ROCK10.33171112
83STK30.32539550
84LRRK20.31829994
85PASK0.31072259
86MAP2K60.30996133
87MAP3K90.30580970
88FGFR20.30274664
89BMPR20.30250624
90SGK2230.29776266
91SGK4940.29776266
92KSR20.29389733
93MAP3K80.29270017
94RPS6KA20.29110033
95MAPK110.29016778
96SIK20.27332167
97CDK50.26923757
98RPS6KB10.25806382
99PAK20.25654706
100PRKCD0.25527200
101SGK20.25258794
102CDC42BPA0.24929604
103STK110.24362687
104CCNB10.24320726
105ERBB30.24311389
106CDK20.24257523
107MUSK0.23881060
108TBK10.23790494
109CHEK10.22987182
110CHEK20.22808269
111CAMK2A0.22717081
112MAPK10.22182445
113RPS6KA10.22032591
114PRKCI0.21650324
115CDK150.21512494
116SGK30.21473492
117CAMK40.21436178
118BCR0.21198496
119FGFR30.20679680
120GSK3B0.20643160
121MAPK100.20542689
122CAMK10.20249558
123PRKAA10.20139721
124CDK180.20003902
125FER0.19943599
126DMPK0.19498575
127DAPK10.18878528
128MAP3K30.18717666
129PAK40.18032985
130CDK10.17724338
131NTRK10.17697561
132MAP3K10.17201372
133AURKA0.16836523
134PRKCH0.15911657
135RPS6KA60.15675814
136RPS6KA30.15672782
137PIK3CG0.15642484
138RPS6KL10.15344476
139RPS6KC10.15344476
140CHUK0.15324089
141MAPK80.14849903
142CSNK1D0.13882629
143CDK11A0.13793770
144MAP2K40.13145329
145CDK140.13096692
146PRKCB0.11810888
147ATM0.11775140
148PRKCQ0.09946193
149TNK20.09067083
150PRKCA0.08903578
151FES0.08202012
152PAK30.08125068
153PRKG10.06551472
154UHMK10.06323845

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.51151739
2Fatty acid biosynthesis_Homo sapiens_hsa000613.88302728
3Histidine metabolism_Homo sapiens_hsa003403.43188446
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33386806
5Tyrosine metabolism_Homo sapiens_hsa003503.16740686
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.15092954
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.61537284
8Amphetamine addiction_Homo sapiens_hsa050312.43481418
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.37528581
10Vitamin B6 metabolism_Homo sapiens_hsa007502.30834217
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27043917
12beta-Alanine metabolism_Homo sapiens_hsa004102.25913950
13Glucagon signaling pathway_Homo sapiens_hsa049222.20411363
14Linoleic acid metabolism_Homo sapiens_hsa005912.16224593
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06837147
16Pyruvate metabolism_Homo sapiens_hsa006202.04491480
17Olfactory transduction_Homo sapiens_hsa047401.91184892
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83165945
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.82611190
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73517354
21Retinol metabolism_Homo sapiens_hsa008301.72732847
22Circadian entrainment_Homo sapiens_hsa047131.71667407
23Synaptic vesicle cycle_Homo sapiens_hsa047211.70449020
24Glycerolipid metabolism_Homo sapiens_hsa005611.66657458
25Renin secretion_Homo sapiens_hsa049241.63787705
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.62286364
27Dorso-ventral axis formation_Homo sapiens_hsa043201.55036310
28Long-term potentiation_Homo sapiens_hsa047201.54051915
29Mineral absorption_Homo sapiens_hsa049781.52512728
30PPAR signaling pathway_Homo sapiens_hsa033201.50248463
31Insulin secretion_Homo sapiens_hsa049111.50103933
32Sphingolipid metabolism_Homo sapiens_hsa006001.47640246
33Tight junction_Homo sapiens_hsa045301.44481862
34Oocyte meiosis_Homo sapiens_hsa041141.43493421
35Cocaine addiction_Homo sapiens_hsa050301.42714268
36Propanoate metabolism_Homo sapiens_hsa006401.39553566
37Caffeine metabolism_Homo sapiens_hsa002321.35417100
38Salivary secretion_Homo sapiens_hsa049701.29996757
39Ether lipid metabolism_Homo sapiens_hsa005651.28692104
40Glutamatergic synapse_Homo sapiens_hsa047241.23031256
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19443984
42Dopaminergic synapse_Homo sapiens_hsa047281.19016748
43Gastric acid secretion_Homo sapiens_hsa049711.18604074
44Estrogen signaling pathway_Homo sapiens_hsa049151.17082219
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16887398
46Cardiac muscle contraction_Homo sapiens_hsa042601.16666231
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14636950
48Hedgehog signaling pathway_Homo sapiens_hsa043401.14584007
49Morphine addiction_Homo sapiens_hsa050321.13584240
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11379364
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10365551
52Taste transduction_Homo sapiens_hsa047421.09799223
53Notch signaling pathway_Homo sapiens_hsa043301.09138618
54Calcium signaling pathway_Homo sapiens_hsa040201.08003040
55Type I diabetes mellitus_Homo sapiens_hsa049401.07599832
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02559726
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02520519
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.02432810
59Butanoate metabolism_Homo sapiens_hsa006501.01424354
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.00993529
61Nicotine addiction_Homo sapiens_hsa050330.98733639
62Fatty acid metabolism_Homo sapiens_hsa012120.97032808
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96236159
64cAMP signaling pathway_Homo sapiens_hsa040240.96137180
65Thyroid hormone synthesis_Homo sapiens_hsa049180.96111827
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93269342
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92924008
68Collecting duct acid secretion_Homo sapiens_hsa049660.92736040
69Glutathione metabolism_Homo sapiens_hsa004800.90355528
70Bile secretion_Homo sapiens_hsa049760.90053224
71Pancreatic secretion_Homo sapiens_hsa049720.88902079
72Fat digestion and absorption_Homo sapiens_hsa049750.88813711
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87695537
74Chemical carcinogenesis_Homo sapiens_hsa052040.86771420
75Cholinergic synapse_Homo sapiens_hsa047250.85871670
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85429448
77Alcoholism_Homo sapiens_hsa050340.84520725
78Basal transcription factors_Homo sapiens_hsa030220.82271869
79mRNA surveillance pathway_Homo sapiens_hsa030150.82251138
80GABAergic synapse_Homo sapiens_hsa047270.82165036
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81678813
82Circadian rhythm_Homo sapiens_hsa047100.80918072
83Choline metabolism in cancer_Homo sapiens_hsa052310.80601458
84Fructose and mannose metabolism_Homo sapiens_hsa000510.79764103
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.78084577
86Type II diabetes mellitus_Homo sapiens_hsa049300.77607926
87Autoimmune thyroid disease_Homo sapiens_hsa053200.72888247
88Oxytocin signaling pathway_Homo sapiens_hsa049210.72432356
89Fatty acid degradation_Homo sapiens_hsa000710.71561164
90Adherens junction_Homo sapiens_hsa045200.69423828
91Selenocompound metabolism_Homo sapiens_hsa004500.66231388
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.66215462
93Allograft rejection_Homo sapiens_hsa053300.65688930
94Arginine biosynthesis_Homo sapiens_hsa002200.64183313
95Endocytosis_Homo sapiens_hsa041440.61374138
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.60899621
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59485546
98Peroxisome_Homo sapiens_hsa041460.58739192
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.58492837
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58467553
101Phototransduction_Homo sapiens_hsa047440.58236840
102Graft-versus-host disease_Homo sapiens_hsa053320.58019367
103VEGF signaling pathway_Homo sapiens_hsa043700.57766750
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56945600
105Arginine and proline metabolism_Homo sapiens_hsa003300.55942539
106ABC transporters_Homo sapiens_hsa020100.55278305
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54732036
108Starch and sucrose metabolism_Homo sapiens_hsa005000.53607522
109Axon guidance_Homo sapiens_hsa043600.51052099
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50340823
111AMPK signaling pathway_Homo sapiens_hsa041520.50030057
112Antigen processing and presentation_Homo sapiens_hsa046120.48475326
113Purine metabolism_Homo sapiens_hsa002300.46485478
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46306935
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44373528
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.42574265
117Inositol phosphate metabolism_Homo sapiens_hsa005620.42479315
118Gap junction_Homo sapiens_hsa045400.41502423
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41241817
120Arachidonic acid metabolism_Homo sapiens_hsa005900.40761547
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39333828
122Huntingtons disease_Homo sapiens_hsa050160.38970729
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.38935608
124Carbon metabolism_Homo sapiens_hsa012000.37514614
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.36248387
126Wnt signaling pathway_Homo sapiens_hsa043100.36129538
127Prostate cancer_Homo sapiens_hsa052150.36059850
128MAPK signaling pathway_Homo sapiens_hsa040100.35442495
129Insulin resistance_Homo sapiens_hsa049310.35032508
130Basal cell carcinoma_Homo sapiens_hsa052170.33003764
131Pentose phosphate pathway_Homo sapiens_hsa000300.32865033
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.30893953
133Serotonergic synapse_Homo sapiens_hsa047260.30854149
134Protein digestion and absorption_Homo sapiens_hsa049740.30457409
135Melanogenesis_Homo sapiens_hsa049160.28795622
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28398980
137Influenza A_Homo sapiens_hsa051640.28022988
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.26849951
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.25912550
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.19819913

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