CCDC188

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.90155699
2plasma membrane fusion (GO:0045026)9.78785477
3epithelial cilium movement (GO:0003351)9.45210042
4axonemal dynein complex assembly (GO:0070286)9.20396665
5reproduction (GO:0000003)9.17179705
6motile cilium assembly (GO:0044458)9.13633470
7regulation of cilium movement (GO:0003352)8.65446557
8response to pheromone (GO:0019236)8.23092891
9negative regulation of inclusion body assembly (GO:0090084)7.90014911
10cilium or flagellum-dependent cell motility (GO:0001539)7.66302194
11cilium movement (GO:0003341)7.50979715
12sperm capacitation (GO:0048240)7.07416343
13single fertilization (GO:0007338)7.06199480
14spermatogenesis (GO:0007283)6.94989048
15male gamete generation (GO:0048232)6.92318442
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.91743232
17organic cation transport (GO:0015695)6.86859474
18synaptonemal complex organization (GO:0070193)6.86597324
19synaptonemal complex assembly (GO:0007130)6.75609102
20rRNA methylation (GO:0031167)6.69145013
21male meiosis (GO:0007140)6.48117685
22regulation of inclusion body assembly (GO:0090083)6.47101895
23piRNA metabolic process (GO:0034587)6.44109825
24protein targeting to Golgi (GO:0000042)6.35908855
25gamete generation (GO:0007276)6.35830739
26microtubule depolymerization (GO:0007019)6.34959173
27phosphatidylethanolamine biosynthetic process (GO:0006646)6.26116613
28calcium ion-dependent exocytosis (GO:0017156)6.08683880
29fertilization (GO:0009566)6.08410048
30establishment of protein localization to Golgi (GO:0072600)6.05573509
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.97813191
32chromosome condensation (GO:0030261)5.81713232
33phosphatidylethanolamine metabolic process (GO:0046337)5.70737842
34spermatid nucleus differentiation (GO:0007289)5.49120557
35DNA packaging (GO:0006323)5.49000369
36germ cell development (GO:0007281)5.46315400
37rRNA modification (GO:0000154)5.43762813
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.36109538
39glycerol ether metabolic process (GO:0006662)5.26727546
40sexual reproduction (GO:0019953)5.16579935
41regulation of Rab GTPase activity (GO:0032313)5.11472339
42positive regulation of Rab GTPase activity (GO:0032851)5.11472339
43cell recognition (GO:0008037)5.11108125
44regulation of microtubule-based movement (GO:0060632)5.09087380
45multicellular organismal reproductive process (GO:0048609)5.00744359
46ventricular system development (GO:0021591)4.93179116
47microtubule severing (GO:0051013)4.91379102
48centriole replication (GO:0007099)4.87826658
49ether metabolic process (GO:0018904)4.86217463
50centriole assembly (GO:0098534)4.79565084
51protein localization to Golgi apparatus (GO:0034067)4.67638076
52single strand break repair (GO:0000012)4.66259244
53chromosome organization involved in meiosis (GO:0070192)4.52303490
54cellular ketone body metabolic process (GO:0046950)4.51747727
55seminiferous tubule development (GO:0072520)4.46435062
56male meiosis I (GO:0007141)4.37159893
57left/right pattern formation (GO:0060972)4.30374012
58DNA methylation involved in gamete generation (GO:0043046)4.28866926
59regulation of transcription involved in cell fate commitment (GO:0060850)4.24620690
60cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.10919358
61sequestering of actin monomers (GO:0042989)4.05953556
62multicellular organismal development (GO:0007275)4.02310816
63chaperone-mediated protein complex assembly (GO:0051131)3.98569684
64ketone body metabolic process (GO:1902224)3.94035056
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88383282
66regulation of centriole replication (GO:0046599)3.82832232
67meiotic nuclear division (GO:0007126)3.79150288
68glomerular visceral epithelial cell development (GO:0072015)3.76375850
69histone H3-K9 demethylation (GO:0033169)3.66980778
70glomerular epithelial cell development (GO:0072310)3.65460499
71regulation of ARF GTPase activity (GO:0032312)3.64412005
72negative regulation of Rho protein signal transduction (GO:0035024)3.63889362
73response to acidic pH (GO:0010447)3.57193602
74musculoskeletal movement (GO:0050881)3.52694343
75multicellular organismal movement (GO:0050879)3.52694343
76microtubule nucleation (GO:0007020)3.50886679
77protein K11-linked deubiquitination (GO:0035871)3.50208910
78protein polyglutamylation (GO:0018095)3.45924881
79cellular response to pH (GO:0071467)3.45084087
80glycolytic process (GO:0006096)3.42212073
81genitalia morphogenesis (GO:0035112)3.41859834
82meiosis I (GO:0007127)3.40996994
83protein refolding (GO:0042026)3.40840687
84protein depolymerization (GO:0051261)3.40186325
85cranial nerve morphogenesis (GO:0021602)3.35607216
86cell differentiation involved in metanephros development (GO:0072202)3.28645500
87cerebral cortex neuron differentiation (GO:0021895)3.28040423
88microtubule polymerization or depolymerization (GO:0031109)3.27326205
89coenzyme catabolic process (GO:0009109)3.21827990
90nucleus organization (GO:0006997)3.20269383
91regulation of spindle checkpoint (GO:0090231)3.17754636
92peptidyl-threonine dephosphorylation (GO:0035970)3.15940149
93interferon-gamma secretion (GO:0072643)3.13126926
94polyamine biosynthetic process (GO:0006596)3.09964749
95mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09369195
96mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09369195
97RNA localization (GO:0006403)3.09250982
98positive regulation of macrophage activation (GO:0043032)3.05533928
99RNA destabilization (GO:0050779)3.04962336
100regulation of interleukin-13 production (GO:0032656)3.03787599
101carnitine transport (GO:0015879)3.03004905
102amino-acid betaine transport (GO:0015838)3.03004905
103polyol catabolic process (GO:0046174)3.02548749
104regulation of T-helper 2 cell differentiation (GO:0045628)3.02422298
105receptor recycling (GO:0001881)3.02361672
106meiotic cell cycle (GO:0051321)3.01900593
107chromatin silencing (GO:0006342)2.99011766
108homeostasis of number of cells within a tissue (GO:0048873)2.98111443
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.97653707
110protein localization to cilium (GO:0061512)2.96363131
111mitotic sister chromatid cohesion (GO:0007064)2.93974986
112regulation of histone H3-K27 methylation (GO:0061085)2.93865314
113negative regulation of gene expression, epigenetic (GO:0045814)2.93653583
114nucleoside diphosphate phosphorylation (GO:0006165)2.88313455
115mitotic G1 DNA damage checkpoint (GO:0031571)2.87719139
116carnitine transmembrane transport (GO:1902603)2.84883507
117regulation of somitogenesis (GO:0014807)2.82924667
118actin cytoskeleton reorganization (GO:0031532)2.82711842
119Golgi to endosome transport (GO:0006895)2.81713659
120histone H4 deacetylation (GO:0070933)2.81120897
121monoubiquitinated protein deubiquitination (GO:0035520)2.77391853
122alditol metabolic process (GO:0019400)2.74273388
123regulation of cilium assembly (GO:1902017)2.72958970
124negative regulation of organelle assembly (GO:1902116)2.69181796
125microtubule-based movement (GO:0007018)2.66573857
126synapsis (GO:0007129)2.66547504
127cilium organization (GO:0044782)2.64735400
128GTP biosynthetic process (GO:0006183)2.58833360
129mitochondrion degradation (GO:0000422)2.58759962
130cellular component assembly involved in morphogenesis (GO:0010927)2.56938816
131cilium assembly (GO:0042384)2.54724362
132meiotic cell cycle process (GO:1903046)2.53318738
133cilium morphogenesis (GO:0060271)2.49837426
134nucleosome disassembly (GO:0006337)2.45901337
135protein-DNA complex disassembly (GO:0032986)2.45901337
136calcium ion import (GO:0070509)2.43600257
137membrane protein intracellular domain proteolysis (GO:0031293)2.42442533
138lactate metabolic process (GO:0006089)2.42311833
139peptidyl-glutamic acid modification (GO:0018200)2.40725088
140sperm motility (GO:0030317)14.5209365
141cell wall macromolecule catabolic process (GO:0016998)13.1707256
142cell wall macromolecule metabolic process (GO:0044036)13.1707256
143acrosome reaction (GO:0007340)12.9478358
144fusion of sperm to egg plasma membrane (GO:0007342)12.6527658
145sperm-egg recognition (GO:0035036)11.4615067
146acrosome assembly (GO:0001675)11.4287224
147binding of sperm to zona pellucida (GO:0007339)10.5000394
148multicellular organism reproduction (GO:0032504)10.3163678
149cell-cell recognition (GO:0009988)10.3115654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.07943004
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.74337519
3EZH2_22144423_ChIP-Seq_EOC_Human4.49758798
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.55413429
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53640875
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34404240
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.05836827
8VDR_22108803_ChIP-Seq_LS180_Human2.58012639
9LXR_22292898_ChIP-Seq_THP-1_Human2.54447675
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54045042
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45780330
12DROSHA_22980978_ChIP-Seq_HELA_Human2.31815561
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.23237768
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17539362
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17488936
16SMC4_20622854_ChIP-Seq_HELA_Human2.11192335
17P68_20966046_ChIP-Seq_HELA_Human2.09851063
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04225455
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02814256
20BCL6_27268052_Chip-Seq_Bcells_Human1.99881975
21ZNF274_21170338_ChIP-Seq_K562_Hela1.94206800
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.93420710
23ERA_21632823_ChIP-Seq_H3396_Human1.86662296
24E2F1_20622854_ChIP-Seq_HELA_Human1.83158735
25RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82387677
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.79877662
27RAC3_21632823_ChIP-Seq_H3396_Human1.79316277
28TP63_22573176_ChIP-Seq_HFKS_Human1.79280720
29PHF8_20622854_ChIP-Seq_HELA_Human1.77950204
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73132633
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72156548
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71643562
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70909522
34SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.65970897
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.65040009
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63786721
37STAT1_17558387_ChIP-Seq_HELA_Human1.63472847
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61570936
39REST_21632747_ChIP-Seq_MESCs_Mouse1.61385936
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55811986
41GATA3_21867929_ChIP-Seq_CD8_Mouse1.53059096
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50787616
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50414941
44NANOG_20526341_ChIP-Seq_ESCs_Human1.49436486
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.49431728
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.48674888
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48135914
48KDM2B_26808549_Chip-Seq_REH_Human1.47591889
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47198976
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47135740
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44801363
52OCT4_20526341_ChIP-Seq_ESCs_Human1.41290343
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39602023
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39268478
55P300_27268052_Chip-Seq_Bcells_Human1.39180681
56MYC_19829295_ChIP-Seq_ESCs_Human1.37383457
57CBP_20019798_ChIP-Seq_JUKART_Human1.37354473
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37354473
59TAF2_19829295_ChIP-Seq_ESCs_Human1.36809583
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36473400
61SA1_27219007_Chip-Seq_Bcells_Human1.34205075
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.33594608
63P53_21459846_ChIP-Seq_SAOS-2_Human1.33200309
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32757492
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.32435711
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31590481
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31455660
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30096261
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28021564
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26915578
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26524884
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25807683
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25089242
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25089242
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24913067
76GF1_26923725_Chip-Seq_HPCs_Mouse1.24237428
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23346996
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.23145711
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.22022010
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.21681312
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20592335
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.20021681
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.19760830
84CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19573714
85TAF15_26573619_Chip-Seq_HEK293_Human1.18722025
86CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18129243
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17574471
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17094912
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16723518
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.16584654
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16239997
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15892466
93OCT4_19829295_ChIP-Seq_ESCs_Human1.15097190
94KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14682637
95MYC_27129775_Chip-Seq_CORNEA_Mouse1.13286491
96KLF4_19829295_ChIP-Seq_ESCs_Human1.13281722
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11908096
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11878579
99TP53_18474530_ChIP-ChIP_U2OS_Human1.11554449
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11147848
101KDM2B_26808549_Chip-Seq_K562_Human1.11101601
102KLF5_25053715_ChIP-Seq_YYC3_Human1.10189332
103TP53_22127205_ChIP-Seq_IMR90_Human1.09227049
104CTCF_21964334_Chip-Seq_Bcells_Human1.09199680
105ERG_20517297_ChIP-Seq_VCAP_Human1.09115399
106GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09086092
107RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08445296
108SPI1_26923725_Chip-Seq_HPCs_Mouse1.07574278
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.07259372
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.06748219
111KDM2B_26808549_Chip-Seq_DND41_Human1.05998982
112CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05669027
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05388115
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04655607
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04190865
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04056143
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03723529
118CTCF_20526341_ChIP-Seq_ESCs_Human1.03684048
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03496432
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.02681377
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02294200
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02144559
123P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02093276
124SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01848068
125TCF7_22412390_ChIP-Seq_EML_Mouse1.01551018
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01473161
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00889920
128ESET_19884257_ChIP-Seq_ESCs_Mouse1.00058182
129CSB_26484114_Chip-Seq_FIBROBLAST_Human1.00028503
130RUNX_20019798_ChIP-Seq_JUKART_Human0.99964296
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.99937206
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99760074
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99628884
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98612059
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.98385378
136YY1_22570637_ChIP-Seq_MALME-3M_Human0.97864424
137GATA1_19941826_ChIP-Seq_K562_Human0.96961640
138NFYB_21822215_ChIP-Seq_K562_Human0.96577126
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.96439980
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95684617
141CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95599884
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.95397661
143CEBPB_22108803_ChIP-Seq_LS180_Human0.95266218
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95265710
145GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95239421
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.94889556
147KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94531563
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94475078
149TBL1_22424771_ChIP-Seq_293T_Human0.94243007
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93726345
151JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93367631
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93274664
153BCOR_27268052_Chip-Seq_Bcells_Human0.93264640
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93212205
155FOXP1_21924763_ChIP-Seq_HESCs_Human0.92759449
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91329344
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90612420
158SOX11_22085726_ChIP-Seq_ESNs_Mouse0.90591172
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.90390246
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90036023
161CTCF_27219007_Chip-Seq_Bcells_Human0.89629998
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89354637
163ELF1_20517297_ChIP-Seq_JURKAT_Human0.88977681
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.88717192
165PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88519437
166P53_22387025_ChIP-Seq_ESCs_Mouse0.88030525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.99969045
2MP0001929_abnormal_gametogenesis5.37780253
3MP0008877_abnormal_DNA_methylation3.62175483
4MP0002161_abnormal_fertility/fecundity3.26888354
5MP0005670_abnormal_white_adipose3.14235953
6MP0002210_abnormal_sex_determination3.10893594
7MP0000678_abnormal_parathyroid_gland2.67165192
8MP0001145_abnormal_male_reproductive2.63478963
9MP0000653_abnormal_sex_gland2.26530164
10MP0005410_abnormal_fertilization16.6145255
11MP0002249_abnormal_larynx_morphology1.91382079
12MP0004233_abnormal_muscle_weight1.75350460
13MP0002653_abnormal_ependyma_morphology1.74613662
14MP0003646_muscle_fatigue1.73576085
15MP0004510_myositis1.62586708
16MP0002132_abnormal_respiratory_system1.62098359
17MP0005451_abnormal_body_composition1.56460981
18MP0005310_abnormal_salivary_gland1.44652621
19MP0005379_endocrine/exocrine_gland_phen1.40475965
20MP0003172_abnormal_lysosome_physiology1.35115343
21MP0002160_abnormal_reproductive_system1.34745036
22MP0000003_abnormal_adipose_tissue1.31436610
23MP0001984_abnormal_olfaction1.30496478
24MP0003718_maternal_effect1.28027838
25MP0009053_abnormal_anal_canal1.22338634
26MP0002234_abnormal_pharynx_morphology1.20798944
27MP0005623_abnormal_meninges_morphology1.14913488
28MP0009046_muscle_twitch1.12367566
29MP0001485_abnormal_pinna_reflex1.10953436
30MP0001765_abnormal_ion_homeostasis1.10688683
31MP0003091_abnormal_cell_migration1.04588302
32MP0002127_abnormal_cardiovascular_syste0.98284031
33MP0001963_abnormal_hearing_physiology0.96350255
34MP0002735_abnormal_chemical_nociception0.94961475
35MP0000681_abnormal_thyroid_gland0.92222007
36MP0002282_abnormal_trachea_morphology0.86203414
37MP0002138_abnormal_hepatobiliary_system0.86123065
38MP0003329_amyloid_beta_deposits0.85723714
39MP0010368_abnormal_lymphatic_system0.85458312
40MP0000026_abnormal_inner_ear0.85408819
41MP0009384_cardiac_valve_regurgitation0.84838946
42MP0001879_abnormal_lymphatic_vessel0.84333616
43MP0000955_abnormal_spinal_cord0.77269569
44MP0000049_abnormal_middle_ear0.76439495
45MP0002733_abnormal_thermal_nociception0.75366188
46MP0003279_aneurysm0.74401990
47MP0005647_abnormal_sex_gland0.74297180
48MP0004036_abnormal_muscle_relaxation0.74052952
49MP0010386_abnormal_urinary_bladder0.73098611
50MP0002736_abnormal_nociception_after0.72202007
51MP0004085_abnormal_heartbeat0.71490791
52MP0005595_abnormal_vascular_smooth0.71477590
53MP0005535_abnormal_body_temperature0.71039892
54MP0005666_abnormal_adipose_tissue0.68738787
55MP0001270_distended_abdomen0.68364786
56MP0003283_abnormal_digestive_organ0.68004051
57MP0005395_other_phenotype0.67749353
58MP0004859_abnormal_synaptic_plasticity0.65960514
59MP0003705_abnormal_hypodermis_morpholog0.65707777
60MP0000733_abnormal_muscle_development0.63713585
61MP0001970_abnormal_pain_threshold0.62725076
62MP0005551_abnormal_eye_electrophysiolog0.62480586
63MP0003115_abnormal_respiratory_system0.60914737
64MP0002933_joint_inflammation0.59790089
65MP0005389_reproductive_system_phenotype0.58857741
66MP0000569_abnormal_digit_pigmentation0.58849720
67MP0005248_abnormal_Harderian_gland0.58600271
68MP0003879_abnormal_hair_cell0.58598576
69MP0004270_analgesia0.58125122
70MP0002557_abnormal_social/conspecific_i0.57320871
71MP0002932_abnormal_joint_morphology0.55725887
72MP0005367_renal/urinary_system_phenotyp0.55537923
73MP0000516_abnormal_urinary_system0.55537923
74MP0001968_abnormal_touch/_nociception0.55151378
75MP0002269_muscular_atrophy0.55106594
76MP0003635_abnormal_synaptic_transmissio0.54277581
77MP0001614_abnormal_blood_vessel0.54074360
78MP0001905_abnormal_dopamine_level0.54071230
79MP0000249_abnormal_blood_vessel0.53950704
80MP0004811_abnormal_neuron_physiology0.53746069
81MP0005167_abnormal_blood-brain_barrier0.52641950
82MP0005423_abnormal_somatic_nervous0.52553293
83MP0008569_lethality_at_weaning0.51809084
84MP0002909_abnormal_adrenal_gland0.51314877
85MP0003878_abnormal_ear_physiology0.50894494
86MP0005377_hearing/vestibular/ear_phenot0.50894494
87MP0001299_abnormal_eye_distance/0.50287312
88MP0005636_abnormal_mineral_homeostasis0.50233634
89MP0001324_abnormal_eye_pigmentation0.49844556
90MP0005409_darkened_coat_color0.49679051
91MP0001958_emphysema0.49317488
92MP0000604_amyloidosis0.48455528
93MP0000013_abnormal_adipose_tissue0.47511825
94MP0000230_abnormal_systemic_arterial0.44875897
95MP0002822_catalepsy0.44867599
96MP0000534_abnormal_ureter_morphology0.44614752
97MP0002063_abnormal_learning/memory/cond0.44509108
98MP0003633_abnormal_nervous_system0.44092524
99MP0008058_abnormal_DNA_repair0.43757942
100MP0005503_abnormal_tendon_morphology0.43634523
101MP0002734_abnormal_mechanical_nocicepti0.43591790
102MP0009115_abnormal_fat_cell0.43411265
103MP0008995_early_reproductive_senescence0.41883238
104MP0003699_abnormal_female_reproductive0.41586271
105MP0000467_abnormal_esophagus_morphology0.41417915
106MP0002272_abnormal_nervous_system0.41313589
107MP0001764_abnormal_homeostasis0.40633326
108MP0005083_abnormal_biliary_tract0.40562335
109MP0003959_abnormal_lean_body0.40296376
110MP0008874_decreased_physiological_sensi0.39867950
111MP0002115_abnormal_skeleton_extremities0.39109334
112MP0004084_abnormal_cardiac_muscle0.38893805
113MP0003137_abnormal_impulse_conducting0.37793026
114MP0000163_abnormal_cartilage_morphology0.36989940
115MP0000358_abnormal_cell_content/0.36948923
116MP0000751_myopathy0.36598657
117MP0005253_abnormal_eye_physiology0.36436163
118MP0002572_abnormal_emotion/affect_behav0.36417402
119MP0001440_abnormal_grooming_behavior0.36038936
120MP0004742_abnormal_vestibular_system0.35513576
121MP0003631_nervous_system_phenotype0.33849124
122MP0003011_delayed_dark_adaptation0.32592192
123MP0002152_abnormal_brain_morphology0.31672770
124MP0002229_neurodegeneration0.31208155
125MP0001293_anophthalmia0.29975455
126MP0003787_abnormal_imprinting0.29559698
127MP0002971_abnormal_brown_adipose0.29502945
128MP0002169_no_abnormal_phenotype0.28622266
129MP0003948_abnormal_gas_homeostasis0.28513219
130MP0002873_normal_phenotype0.28493784
131MP0002067_abnormal_sensory_capabilities0.28091883
132MP0003183_abnormal_peptide_metabolism0.27845106
133MP0005375_adipose_tissue_phenotype0.27383066
134MP0005397_hematopoietic_system_phenotyp0.27079563
135MP0001545_abnormal_hematopoietic_system0.27079563
136MP0002102_abnormal_ear_morphology0.26364036
137MP0009745_abnormal_behavioral_response0.26337060
138MP0009278_abnormal_bone_marrow0.26301765
139MP0002928_abnormal_bile_duct0.26167977
140MP0006036_abnormal_mitochondrial_physio0.26127255
141MP0003942_abnormal_urinary_system0.25480363
142MP0001486_abnormal_startle_reflex0.25313513
143MP0003861_abnormal_nervous_system0.25163223
144MP0008961_abnormal_basal_metabolism0.24291528
145MP0002064_seizures0.22523412
146MP0002295_abnormal_pulmonary_circulatio0.22352202
147MP0002882_abnormal_neuron_morphology0.22085248
148MP0002405_respiratory_system_inflammati0.21986973
149MP0001348_abnormal_lacrimal_gland0.21272292
150MP0005391_vision/eye_phenotype0.20525366
151MP0001502_abnormal_circadian_rhythm0.19864457
152MP0002693_abnormal_pancreas_physiology0.19698971
153MP0000920_abnormal_myelination0.19495115
154MP0001835_abnormal_antigen_presentation0.19218949
155MP0005195_abnormal_posterior_eye0.19086238
156MP0001849_ear_inflammation0.18652720
157MP0002066_abnormal_motor_capabilities/c0.17489489
158MP0000685_abnormal_immune_system0.17039553
159MP0004087_abnormal_muscle_fiber0.16785461
160MP0004145_abnormal_muscle_electrophysio0.16692573

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.19389698
2Abnormal respiratory motile cilium morphology (HP:0005938)9.19389698
3Abnormal respiratory motile cilium physiology (HP:0012261)9.08526815
4Severe visual impairment (HP:0001141)7.67145939
5Chronic bronchitis (HP:0004469)7.16107004
6Rhinitis (HP:0012384)7.15354631
7Abnormal ciliary motility (HP:0012262)7.08569055
8Infertility (HP:0000789)7.08446659
9Nasal polyposis (HP:0100582)6.24770545
10Abnormality of the nasal mucosa (HP:0000433)5.12298441
11Male infertility (HP:0003251)5.07146101
12Bronchitis (HP:0012387)4.41886257
13Bony spicule pigmentary retinopathy (HP:0007737)4.39212974
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.34154314
15Chronic hepatic failure (HP:0100626)4.30459641
16Attenuation of retinal blood vessels (HP:0007843)4.21800065
17Bronchiectasis (HP:0002110)4.17783562
18Hypoplastic ischia (HP:0003175)4.14637210
19Hyperkalemia (HP:0002153)4.12254564
20Nephronophthisis (HP:0000090)4.12146574
21Resting tremor (HP:0002322)3.93200605
22Abnormality of the ischium (HP:0003174)3.69774821
23Abnormal spermatogenesis (HP:0008669)3.60323754
24Cone-rod dystrophy (HP:0000548)3.57867151
25Enlarged epiphyses (HP:0010580)3.54000281
26Abnormality of macular pigmentation (HP:0008002)3.52429885
27Hypoalphalipoproteinemia (HP:0003233)3.33476194
28Potter facies (HP:0002009)3.30657700
29Facial shape deformation (HP:0011334)3.30657700
30Recurrent otitis media (HP:0000403)3.17265213
31Progressive sensorineural hearing impairment (HP:0000408)3.15258477
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.14814385
33Recurrent sinusitis (HP:0011108)3.14155947
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.07702037
35Abnormality of the renal medulla (HP:0100957)3.02710780
36Hypoplasia of the thymus (HP:0000778)3.01620534
37Abnormal rod and cone electroretinograms (HP:0008323)2.99592961
38Renovascular hypertension (HP:0100817)2.90123089
39Abnormality of the aortic arch (HP:0012303)2.74044911
40Abnormal gallbladder physiology (HP:0012438)2.72539856
41Cholecystitis (HP:0001082)2.72539856
42Tubulointerstitial nephritis (HP:0001970)2.67561216
43Broad face (HP:0000283)2.65641245
44Flattened epiphyses (HP:0003071)2.64758226
45Insulin-resistant diabetes mellitus (HP:0000831)2.60305856
46Postural instability (HP:0002172)2.59259331
47Recurrent bronchitis (HP:0002837)2.59072425
48Abnormality of midbrain morphology (HP:0002418)2.59031613
49Molar tooth sign on MRI (HP:0002419)2.59031613
50Truncal obesity (HP:0001956)2.56947729
51Impulsivity (HP:0100710)2.50806811
52Portal hypertension (HP:0001409)2.49898413
53Tubular atrophy (HP:0000092)2.45460802
54Abnormality of the costochondral junction (HP:0000919)2.45230788
55Unilateral renal agenesis (HP:0000122)2.45022167
56Atelectasis (HP:0100750)2.41717613
57Medial flaring of the eyebrow (HP:0010747)2.40267827
58Abnormality of the hepatic vasculature (HP:0006707)2.38383355
59Double outlet right ventricle (HP:0001719)2.37738988
60Congenital malformation of the right heart (HP:0011723)2.37738988
61Menstrual irregularities (HP:0000858)2.34039287
62Bradycardia (HP:0001662)2.32330986
63Focal segmental glomerulosclerosis (HP:0000097)2.28227964
64Tubulointerstitial abnormality (HP:0001969)2.28150166
65Dyschromatopsia (HP:0007641)2.27898215
66Choroideremia (HP:0001139)2.21467081
67Epiphyseal dysplasia (HP:0002656)2.21382932
68Amelogenesis imperfecta (HP:0000705)2.20511963
69Progressive hearing impairment (HP:0001730)2.19726121
70Heterotopia (HP:0002282)2.19439008
71Flat capital femoral epiphysis (HP:0003370)2.14592261
72Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13786343
73Absent epiphyses (HP:0010577)2.13786343
74Abnormality of the femoral head (HP:0003368)2.12780194
75Abnormality of dental color (HP:0011073)2.11105527
76Azoospermia (HP:0000027)2.10688631
77Abnormality of potassium homeostasis (HP:0011042)2.10575797
78Ventricular tachycardia (HP:0004756)2.10211200
79Cerebellar dysplasia (HP:0007033)2.09034265
80Hand muscle atrophy (HP:0009130)2.08871855
81Widely patent fontanelles and sutures (HP:0004492)2.08804007
82Gonadotropin excess (HP:0000837)2.05849811
83Abnormality of the epiphysis of the femoral head (HP:0010574)2.04281691
84Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.04061331
85Abnormality of femoral epiphyses (HP:0006499)2.04061331
86Protuberant abdomen (HP:0001538)2.02827688
87Atrophic scars (HP:0001075)2.00249746
88Dynein arm defect of respiratory motile cilia (HP:0012255)13.5236974
89Absent/shortened dynein arms (HP:0200106)13.5236974
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4527041
91Decreased central vision (HP:0007663)1.97986858
92Hypophosphatemic rickets (HP:0004912)1.97589848
93Upper limb amyotrophy (HP:0009129)1.97233136
94Distal upper limb amyotrophy (HP:0007149)1.97233136
95Cervical subluxation (HP:0003308)1.95386482
96Occipital encephalocele (HP:0002085)1.93941585
97Insulin resistance (HP:0000855)1.93625516
98Vertebral clefting (HP:0008428)1.92726639
99Hyperthyroidism (HP:0000836)1.91746834
100Neurofibrillary tangles (HP:0002185)1.88070638
101Spastic tetraparesis (HP:0001285)1.87774701
102Intellectual disability, moderate (HP:0002342)1.86972062
103Amblyopia (HP:0000646)1.84211523
104Tubulointerstitial fibrosis (HP:0005576)1.84096796
105Upper limb muscle weakness (HP:0003484)1.83380953
106Abnormality of the parathyroid morphology (HP:0011766)1.82986423
107Thin bony cortex (HP:0002753)1.78554350
108Acanthosis nigricans (HP:0000956)1.77231039
109Hemorrhage of the eye (HP:0011885)1.76236825
110Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74664500
111Polydipsia (HP:0001959)1.74614127
112Abnormal drinking behavior (HP:0030082)1.74614127
113Exercise-induced myalgia (HP:0003738)1.72970722
114Peripheral hypomyelination (HP:0007182)1.72867578
115Ectopia lentis (HP:0001083)1.72214088
116Glomerulosclerosis (HP:0000096)1.70970315
117Asymmetric septal hypertrophy (HP:0001670)1.68315850
118Bundle branch block (HP:0011710)1.66459692
119Stage 5 chronic kidney disease (HP:0003774)1.65203776
120Postaxial foot polydactyly (HP:0001830)1.62709156
121Congenital hepatic fibrosis (HP:0002612)1.60102345
122Constricted visual fields (HP:0001133)1.58093708
123Abnormality of renal excretion (HP:0011036)1.55881139
124Cerebral inclusion bodies (HP:0100314)1.54781783
125Aplasia/Hypoplasia of the lens (HP:0008063)1.53633147
126Myoglobinuria (HP:0002913)1.52921102
127Oculomotor apraxia (HP:0000657)1.50260558
128Abnormal biliary tract physiology (HP:0012439)1.48780972
129Bile duct proliferation (HP:0001408)1.48780972
130Abnormality of the renal cortex (HP:0011035)1.45675368
131Hemiparesis (HP:0001269)1.41024814
132Loss of speech (HP:0002371)1.40651458
133Dysmetric saccades (HP:0000641)1.40478556
134Bell-shaped thorax (HP:0001591)1.39303547
135Easy fatigability (HP:0003388)1.36656444
136Fatigable weakness (HP:0003473)1.36590643
137Abnormality of the neuromuscular junction (HP:0003398)1.36590643
138Short ribs (HP:0000773)1.36523702
139Postaxial hand polydactyly (HP:0001162)1.34625478
140Broad distal phalanx of finger (HP:0009836)1.34335462
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.34334620
142Progressive cerebellar ataxia (HP:0002073)1.32781695
143Abnormal urine output (HP:0012590)1.32224766
144Abnormality of saccadic eye movements (HP:0000570)1.31689354
145Abnormality of the dental root (HP:0006486)1.31373645
146Taurodontia (HP:0000679)1.31373645
147Abnormality of permanent molar morphology (HP:0011071)1.31373645
148Deformed sella turcica (HP:0002681)1.30818088
149Cystic liver disease (HP:0006706)1.30377329
150Abnormality of dentin (HP:0010299)1.30139344
151Lissencephaly (HP:0001339)1.29727023
152Exercise-induced muscle cramps (HP:0003710)1.29070040
153Polymicrogyria (HP:0002126)1.27186815
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.25453871
155Neoplasm of the heart (HP:0100544)1.25311076
156Abnormality of the lower motor neuron (HP:0002366)1.24256606
157Abnormal ventriculo-arterial connection (HP:0011563)1.24002732
158Transposition of the great arteries (HP:0001669)1.24002732
159Abnormal connection of the cardiac segments (HP:0011545)1.24002732
160Abnormality of ocular smooth pursuit (HP:0000617)1.22437215
161Abnormality of the dental pulp (HP:0006479)1.22408912
162Sensory axonal neuropathy (HP:0003390)1.21344533
163Hypercholesterolemia (HP:0003124)1.19987894
164Abnormality of molar (HP:0011077)1.19302854
165Abnormality of molar morphology (HP:0011070)1.19302854
166Renal dysplasia (HP:0000110)1.17439453
167Gait imbalance (HP:0002141)1.17436130
168Rhabdomyolysis (HP:0003201)1.17051110
169Congenital primary aphakia (HP:0007707)1.13922422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.79873746
2PDK37.79873746
3PLK47.27737565
4TESK16.64527580
5PRKD35.74202577
6PDK24.97351890
7DDR24.76678087
8ICK4.71144568
9INSRR4.22023726
10BRD42.81115434
11PLK22.39363163
12MAP4K22.27320734
13PTK2B2.16041367
14STK382.08693090
15WNK41.83136049
16PBK1.76018992
17STK391.74329887
18DYRK1B1.71431206
19PIK3CG1.69772180
20MST1R1.68332604
21CDK121.53080094
22PNCK1.45420430
23PDK11.40006394
24NEK21.37092662
25MAP2K31.17658732
26RPS6KA21.14046336
27TIE11.07898325
28CDK71.05494032
29MAP3K111.04748903
30FLT31.00300467
31CAMK1D0.97494179
32SIK20.97355369
33RIPK40.90055584
34PDPK10.87194444
35TYRO30.85047019
36MET0.84555497
37NTRK10.82089245
38MAP3K20.80818382
39ERN10.78218343
40MAP3K70.75064227
41AKT30.74398039
42WNK10.72948599
43EEF2K0.72846352
44MAPK150.72743633
45PDGFRA0.71712746
46IRAK10.71454712
47MAP2K20.67275073
48DYRK30.67085125
49ROCK10.66869334
50RPS6KL10.66399137
51RPS6KC10.66399137
52UHMK10.64040547
53MAP3K100.62200910
54MAP3K130.61951071
55LATS20.60248334
56PRKAA20.60123844
57CCNB10.59072079
58RPS6KA60.58530614
59NTRK20.57327635
60JAK30.57176358
61MAP2K60.57026613
62LMTK20.52809174
63PINK10.50645229
64TNK20.50619179
65CHEK20.48817531
66CAMK1G0.48532225
67PASK0.48078705
68MAPK10.47508829
69PAK60.43342965
70NTRK30.43185570
71MAPKAPK50.42726408
72IRAK20.41711181
73PRKCG0.41201117
74MAP2K40.41081222
75CAMKK10.40782175
76MAP3K80.40583218
77PAK10.40329334
78KIT0.40010022
79STK38L0.39497249
80CDK40.38846201
81CDK20.37048928
82MUSK0.36260641
83TTN0.35212901
84MARK20.34699619
85TTK0.33762732
86STK30.32233316
87TESK20.32211250
88ZAP700.31832048
89PRKD20.31489660
90MAPK110.30885073
91CDK10.30300155
92PAK20.28322962
93CAMK40.27516007
94SGK4940.27313733
95SGK2230.27313733
96PRKCH0.26326686
97CHEK10.25277980
98MAPK100.24843251
99CDK150.24370173
100PTK20.23922561
101PRKAA10.23711251
102SIK10.23238765
103PRKCZ0.22393366
104EPHA40.21831135
105FRK0.21783602
106CDK180.21380180
107MAP3K60.21021554
108ATM0.20328654
109MTOR0.20282607
110AKT10.19490864
111MAPK140.19145516
112MINK10.18355807
113PRKG20.18328755
114DYRK1A0.18275612
115CDK11A0.18121152
116PKN20.18076317
117MARK10.17046276
118CDK140.16996070
119PRKCQ0.16526781
120BLK0.16109463
121STK110.15622562
122RIPK10.14118776
123STK100.13135389
124MAP3K10.13119420
125MAP3K90.10928294
126NEK60.10566229
127ATR0.10066339
128MAP3K40.09785508
129PAK40.09114421
130CAMK2A0.08761953
131RPS6KB10.08372203
132RPS6KA10.08079175
133DAPK20.07955642
134GSK3B0.07193633
135GRK50.06985346
136MAPK80.06945419
137PKN10.06926087
138PRKCD0.06509147
139PRKG10.05845133
140PRKCB0.05759693
141PTK60.05509243
142CDK30.04665226
143PRKACG0.04418550
144CSF1R0.04291107
145PRKCA0.04166117
146BRSK10.03904338
147BRAF0.03541427
148BMPR20.02517297
149CDK50.02381294
150MAP4K10.02014776
151CAMK10.01948656
152RPS6KA30.01818313
153PRKACB-0.0235431
154PRKACA-0.0201177
155EGFR-0.0198456
156CSNK1D-0.0196495
157SRC-0.0172338
158EPHB1-0.0110541
159TRIB3-0.0104709
160KSR2-0.0102464

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.41160732
2Fatty acid biosynthesis_Homo sapiens_hsa000614.66181508
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34045272
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.14237639
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.96585388
6Pyruvate metabolism_Homo sapiens_hsa006202.87089064
7Linoleic acid metabolism_Homo sapiens_hsa005912.84791045
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.76852947
9Vitamin B6 metabolism_Homo sapiens_hsa007502.69318612
10Glucagon signaling pathway_Homo sapiens_hsa049222.48637939
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06464323
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99601501
13Propanoate metabolism_Homo sapiens_hsa006401.99433801
14Glycerolipid metabolism_Homo sapiens_hsa005611.91663604
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84578102
16Amphetamine addiction_Homo sapiens_hsa050311.80633644
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.77009263
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76768346
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.74204936
20PPAR signaling pathway_Homo sapiens_hsa033201.64857782
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63412435
22Fructose and mannose metabolism_Homo sapiens_hsa000511.53859085
23Selenocompound metabolism_Homo sapiens_hsa004501.50845698
24Dorso-ventral axis formation_Homo sapiens_hsa043201.50737993
25Mineral absorption_Homo sapiens_hsa049781.48032901
26Cardiac muscle contraction_Homo sapiens_hsa042601.45378680
27Oocyte meiosis_Homo sapiens_hsa041141.45211638
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.42852121
29Renin secretion_Homo sapiens_hsa049241.40716505
30Basal transcription factors_Homo sapiens_hsa030221.39644326
31Butanoate metabolism_Homo sapiens_hsa006501.39566676
32Insulin secretion_Homo sapiens_hsa049111.36129743
33Fat digestion and absorption_Homo sapiens_hsa049751.34757838
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32018355
35Ether lipid metabolism_Homo sapiens_hsa005651.31732605
36Fatty acid metabolism_Homo sapiens_hsa012121.27028763
37Pentose phosphate pathway_Homo sapiens_hsa000301.23124898
38Fatty acid degradation_Homo sapiens_hsa000711.17928798
39Salivary secretion_Homo sapiens_hsa049701.15876973
40Long-term potentiation_Homo sapiens_hsa047201.15427626
41Synaptic vesicle cycle_Homo sapiens_hsa047211.14105769
42Carbon metabolism_Homo sapiens_hsa012001.13611614
43ECM-receptor interaction_Homo sapiens_hsa045121.11260497
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07674760
45Acute myeloid leukemia_Homo sapiens_hsa052211.05014715
46Antigen processing and presentation_Homo sapiens_hsa046121.00894797
47Type I diabetes mellitus_Homo sapiens_hsa049401.00826615
48Other glycan degradation_Homo sapiens_hsa005110.99865159
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98507700
50Estrogen signaling pathway_Homo sapiens_hsa049150.96539262
51Phenylalanine metabolism_Homo sapiens_hsa003600.95936909
52Collecting duct acid secretion_Homo sapiens_hsa049660.93171252
53Influenza A_Homo sapiens_hsa051640.92195845
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90527782
55mTOR signaling pathway_Homo sapiens_hsa041500.90197905
56Prolactin signaling pathway_Homo sapiens_hsa049170.89957048
57Hedgehog signaling pathway_Homo sapiens_hsa043400.89651639
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.89412073
59Notch signaling pathway_Homo sapiens_hsa043300.87660345
60Circadian entrainment_Homo sapiens_hsa047130.87457403
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.84311447
62MAPK signaling pathway_Homo sapiens_hsa040100.83602291
63Thyroid hormone synthesis_Homo sapiens_hsa049180.83134760
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83062525
65Gastric acid secretion_Homo sapiens_hsa049710.82455253
66Biosynthesis of amino acids_Homo sapiens_hsa012300.82227503
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.82201230
68Pancreatic secretion_Homo sapiens_hsa049720.81510621
69Focal adhesion_Homo sapiens_hsa045100.80513079
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79873705
71Calcium signaling pathway_Homo sapiens_hsa040200.78536835
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78022757
73RNA transport_Homo sapiens_hsa030130.77019308
74Olfactory transduction_Homo sapiens_hsa047400.76248949
75Allograft rejection_Homo sapiens_hsa053300.76131477
76Bile secretion_Homo sapiens_hsa049760.75961626
77Cholinergic synapse_Homo sapiens_hsa047250.75646320
78Taste transduction_Homo sapiens_hsa047420.75049175
79Purine metabolism_Homo sapiens_hsa002300.73700326
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.73473170
81Viral myocarditis_Homo sapiens_hsa054160.72860232
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72559845
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72101330
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69118942
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.66877556
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65218163
87Autoimmune thyroid disease_Homo sapiens_hsa053200.65019840
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63870091
89Legionellosis_Homo sapiens_hsa051340.62523960
90Endocytosis_Homo sapiens_hsa041440.61935526
91Glutamatergic synapse_Homo sapiens_hsa047240.61628826
92Arachidonic acid metabolism_Homo sapiens_hsa005900.61462710
93cAMP signaling pathway_Homo sapiens_hsa040240.61391463
94Inositol phosphate metabolism_Homo sapiens_hsa005620.60307914
95VEGF signaling pathway_Homo sapiens_hsa043700.59402806
96Choline metabolism in cancer_Homo sapiens_hsa052310.58532767
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57425510
98Fanconi anemia pathway_Homo sapiens_hsa034600.57385816
99Toxoplasmosis_Homo sapiens_hsa051450.55970352
100Graft-versus-host disease_Homo sapiens_hsa053320.55275197
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55092764
102Glutathione metabolism_Homo sapiens_hsa004800.54212298
103mRNA surveillance pathway_Homo sapiens_hsa030150.53085447
104Arginine biosynthesis_Homo sapiens_hsa002200.52875536
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52576813
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50674103
107Nicotine addiction_Homo sapiens_hsa050330.50076627
108Type II diabetes mellitus_Homo sapiens_hsa049300.49572829
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48951823
110Non-small cell lung cancer_Homo sapiens_hsa052230.47592902
111Alcoholism_Homo sapiens_hsa050340.47524463
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46874127
113Glioma_Homo sapiens_hsa052140.46682796
114Protein digestion and absorption_Homo sapiens_hsa049740.46509603
115Tight junction_Homo sapiens_hsa045300.44754538
116Insulin resistance_Homo sapiens_hsa049310.44596030
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.44486724
118Systemic lupus erythematosus_Homo sapiens_hsa053220.44250434
119Insulin signaling pathway_Homo sapiens_hsa049100.43230954
120Cocaine addiction_Homo sapiens_hsa050300.42799632
121Huntingtons disease_Homo sapiens_hsa050160.41141252
122B cell receptor signaling pathway_Homo sapiens_hsa046620.41040128
123Arginine and proline metabolism_Homo sapiens_hsa003300.40015056
124Chemical carcinogenesis_Homo sapiens_hsa052040.39409755
125Platelet activation_Homo sapiens_hsa046110.39026278
126AMPK signaling pathway_Homo sapiens_hsa041520.38554676
127Sulfur relay system_Homo sapiens_hsa041220.38213526
128ABC transporters_Homo sapiens_hsa020100.38128643
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37895331
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37222377
131Dopaminergic synapse_Homo sapiens_hsa047280.36919106
132Prostate cancer_Homo sapiens_hsa052150.36260352
133Serotonergic synapse_Homo sapiens_hsa047260.35949369
134ErbB signaling pathway_Homo sapiens_hsa040120.35466692
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34667532
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33435523
137Morphine addiction_Homo sapiens_hsa050320.32461187
138Oxytocin signaling pathway_Homo sapiens_hsa049210.29833591
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28834157
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27991659
141Salmonella infection_Homo sapiens_hsa051320.27578357
142HIF-1 signaling pathway_Homo sapiens_hsa040660.25036940
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24621318
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19145054
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16911148
146Renin-angiotensin system_Homo sapiens_hsa046140.16733962
147Metabolic pathways_Homo sapiens_hsa011000.15377411

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