CCDC190

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.07482175
2primary alcohol catabolic process (GO:0034310)8.19828985
3regulation of cilium movement (GO:0003352)7.80984516
4left/right axis specification (GO:0070986)7.22713264
5vitamin transmembrane transport (GO:0035461)6.78369123
6ventricular system development (GO:0021591)6.75153728
7diterpenoid biosynthetic process (GO:0016102)6.69445714
8ethanol metabolic process (GO:0006067)6.57359275
9microtubule bundle formation (GO:0001578)6.40778480
10intraciliary transport (GO:0042073)6.31369833
11cilium organization (GO:0044782)6.05600592
12cilium assembly (GO:0042384)5.87581990
13pyrimidine-containing compound transmembrane transport (GO:0072531)5.44664383
14locomotory exploration behavior (GO:0035641)5.44560993
15L-amino acid import (GO:0043092)5.14445128
16ethanol oxidation (GO:0006069)5.11978503
17response to xenobiotic stimulus (GO:0009410)5.07598740
18one-carbon compound transport (GO:0019755)5.04517011
19cellular potassium ion homeostasis (GO:0030007)5.02070689
20centriole assembly (GO:0098534)4.94541590
21glomerular epithelial cell development (GO:0072310)4.91154349
22tolerance induction (GO:0002507)4.85931251
23lung epithelium development (GO:0060428)4.85243523
24amino acid import (GO:0043090)4.84096839
25neurotransmitter-gated ion channel clustering (GO:0072578)4.79599081
26sodium ion export (GO:0071436)4.77520488
27microtubule-based movement (GO:0007018)4.74483418
28protein localization to cilium (GO:0061512)4.73900160
29negative regulation of T cell differentiation in thymus (GO:0033085)4.71887938
30negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.70046509
31cellular component assembly involved in morphogenesis (GO:0010927)4.66544190
32terpenoid biosynthetic process (GO:0016114)4.63715017
33retinoic acid metabolic process (GO:0042573)4.61087826
34cell communication by electrical coupling (GO:0010644)4.55108202
35regulation of microtubule-based movement (GO:0060632)4.53978526
36establishment of apical/basal cell polarity (GO:0035089)4.49788768
37regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49256707
38negative regulation of astrocyte differentiation (GO:0048712)4.48283922
39sperm capacitation (GO:0048240)4.48075557
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42554301
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.42334983
42synaptic vesicle maturation (GO:0016188)4.40323985
43negative regulation of humoral immune response (GO:0002921)4.37746620
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37574178
45negative regulation of B cell mediated immunity (GO:0002713)4.37557728
46negative regulation of immunoglobulin mediated immune response (GO:0002890)4.37557728
47cilium morphogenesis (GO:0060271)4.34716637
48vocalization behavior (GO:0071625)4.30909972
49cell projection assembly (GO:0030031)4.26537394
50regulation of interleukin-5 production (GO:0032674)4.25032616
51gamma-aminobutyric acid transport (GO:0015812)4.22175488
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.14065050
53glutamate secretion (GO:0014047)4.07154524
54neuron cell-cell adhesion (GO:0007158)4.05481465
55layer formation in cerebral cortex (GO:0021819)4.03813617
56positive regulation of tolerance induction (GO:0002645)4.01818589
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.00603417
58regulation of glutamate receptor signaling pathway (GO:1900449)3.98444736
59regulation of germinal center formation (GO:0002634)3.96148103
60establishment or maintenance of monopolar cell polarity (GO:0061339)3.95985679
61establishment of monopolar cell polarity (GO:0061162)3.95985679
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.94121891
63synaptic vesicle exocytosis (GO:0016079)3.92557249
64C4-dicarboxylate transport (GO:0015740)3.90147897
65potassium ion import (GO:0010107)3.82889202
66neuronal action potential propagation (GO:0019227)3.81989319
67glial cell proliferation (GO:0014009)3.81041107
68nucleoside diphosphate phosphorylation (GO:0006165)3.81020425
69regulation of interleukin-13 production (GO:0032656)3.80776718
70cytoplasmic microtubule organization (GO:0031122)3.79979612
71alanine transport (GO:0032328)3.79865648
72postsynaptic membrane organization (GO:0001941)3.75841036
73protein localization to synapse (GO:0035418)3.74170287
74regulation of synaptic vesicle exocytosis (GO:2000300)3.73762738
75glutamate receptor signaling pathway (GO:0007215)3.70998144
76response to auditory stimulus (GO:0010996)3.70553042
77negative regulation of inclusion body assembly (GO:0090084)3.68213930
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.67427669
79exploration behavior (GO:0035640)3.67141193
80retinol metabolic process (GO:0042572)3.66362299
81negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66213317
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.66015669
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61671435
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60729084
85lateral ventricle development (GO:0021670)3.59795207
86regulation of beta-amyloid formation (GO:1902003)3.58974582
87neurotransmitter secretion (GO:0007269)3.57088844
88microtubule depolymerization (GO:0007019)3.54613518
89primary alcohol metabolic process (GO:0034308)3.53519789
90synaptic transmission, glutamatergic (GO:0035249)3.51575321
91regulation of neuronal synaptic plasticity (GO:0048168)3.51100460
92establishment of planar polarity (GO:0001736)3.50705812
93establishment of tissue polarity (GO:0007164)3.50705812
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50611546
95regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49342980
96O-glycan processing (GO:0016266)3.49240237
97cellular sodium ion homeostasis (GO:0006883)3.48902532
98proline transport (GO:0015824)3.46946909
99glutathione derivative metabolic process (GO:1901685)3.44560278
100glutathione derivative biosynthetic process (GO:1901687)3.44560278
101glycine transport (GO:0015816)3.43338732
102cerebellar granule cell differentiation (GO:0021707)3.41821213
103long-term synaptic potentiation (GO:0060291)3.41371433
104microtubule polymerization or depolymerization (GO:0031109)3.40349170
105long-term memory (GO:0007616)3.40089796
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39045483
107potassium ion homeostasis (GO:0055075)3.38058977
108positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38012260
109regulation of synaptic vesicle transport (GO:1902803)3.37374386
110regulation of synapse structural plasticity (GO:0051823)3.36675138
111positive regulation of smoothened signaling pathway (GO:0045880)3.36094491
112exogenous drug catabolic process (GO:0042738)3.35727723
113response to histamine (GO:0034776)3.34264816
114regulation of synaptic transmission, glutamatergic (GO:0051966)3.34124212
115adenine nucleotide transport (GO:0051503)3.33722645
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29103522
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28760062
118synaptic vesicle docking involved in exocytosis (GO:0016081)3.27450712
119ovulation cycle (GO:0042698)3.26914763
120atrial cardiac muscle cell action potential (GO:0086014)3.26405956
121presynaptic membrane assembly (GO:0097105)3.25417486
122dendritic spine morphogenesis (GO:0060997)3.25154925
123dendrite morphogenesis (GO:0048813)3.21164116
124cellular response to cholesterol (GO:0071397)3.17572364
125neurotransmitter uptake (GO:0001504)3.16837491
126central nervous system myelination (GO:0022010)3.16752411
127axon ensheathment in central nervous system (GO:0032291)3.16752411
128acidic amino acid transport (GO:0015800)3.16006288
129regulation of astrocyte differentiation (GO:0048710)3.14650095
130negative regulation of sodium ion transport (GO:0010766)3.12284131
131neurotransmitter transport (GO:0006836)3.05238787
132neuron-neuron synaptic transmission (GO:0007270)3.04940853
133hydrogen peroxide biosynthetic process (GO:0050665)3.04783715
134auditory behavior (GO:0031223)3.04075866
135regulation of amyloid precursor protein catabolic process (GO:1902991)3.03623794
136regulation of microtubule depolymerization (GO:0031114)3.00582528
137axonemal dynein complex assembly (GO:0070286)21.6394005
138innervation (GO:0060384)2.98955897
139lateral sprouting from an epithelium (GO:0060601)2.98445415
140regulation of tolerance induction (GO:0002643)2.94261467
141multicellular organismal water homeostasis (GO:0050891)2.91435987
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.91377390
143transmission of nerve impulse (GO:0019226)2.90985960
144L-glutamate transport (GO:0015813)2.88786659
145presynaptic membrane organization (GO:0097090)2.88244414
146regulation of synaptic plasticity (GO:0048167)2.88118099
147determination of left/right symmetry (GO:0007368)2.87854898
148progesterone metabolic process (GO:0042448)2.87158222
149regulation of neurotransmitter levels (GO:0001505)2.85505352
150synapse assembly (GO:0007416)2.85122059
151purine nucleotide transport (GO:0015865)2.83141794
152neuromuscular process controlling balance (GO:0050885)2.82874956
153chondroitin sulfate catabolic process (GO:0030207)2.81546540
154prepulse inhibition (GO:0060134)2.80041330
155microtubule-based process (GO:0007017)2.79931815
156aldehyde catabolic process (GO:0046185)2.79699359
157regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79624511
158negative regulation of glial cell differentiation (GO:0045686)2.79465085
159membrane repolarization (GO:0086009)2.79003882
160positive regulation of membrane potential (GO:0045838)2.77816526
161sperm motility (GO:0030317)2.76728512
162determination of bilateral symmetry (GO:0009855)2.76262377
163carnitine metabolic process (GO:0009437)2.76132138
164smoothened signaling pathway (GO:0007224)2.75808222
165cerebral cortex radially oriented cell migration (GO:0021799)2.75052630
166positive regulation of dendritic spine development (GO:0060999)2.73696026
167positive regulation of synaptic transmission (GO:0050806)2.73470440
168peripheral nervous system axon ensheathment (GO:0032292)2.72789554
169myelination in peripheral nervous system (GO:0022011)2.72789554
170specification of symmetry (GO:0009799)2.72589203
171dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71369849
172female mating behavior (GO:0060180)2.71335243
173excretion (GO:0007588)2.70111752
174centriole replication (GO:0007099)2.69043927
175reactive oxygen species biosynthetic process (GO:1903409)2.68383311
176apical protein localization (GO:0045176)2.66063440
177hypotonic response (GO:0006971)2.65810732
178phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.65639990
179organelle assembly (GO:0070925)2.63927473
180retinal rod cell development (GO:0046548)2.62818662
181drug catabolic process (GO:0042737)2.61343951
182regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.60091109
183oligosaccharide biosynthetic process (GO:0009312)2.59915995
184protein O-linked glycosylation (GO:0006493)2.50819243
185regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.50775926
186hydrogen peroxide catabolic process (GO:0042744)2.49335289
187regulation of response to osmotic stress (GO:0047484)2.49138147
188iron ion import (GO:0097286)2.48945322
189phosphatidylcholine biosynthetic process (GO:0006656)2.48192928
190water homeostasis (GO:0030104)2.47003283
191negative regulation of microtubule depolymerization (GO:0007026)2.43838016
192heart looping (GO:0001947)2.41744023
193calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.40772311
194regulation of autophagic vacuole assembly (GO:2000785)2.39414409
195cilium or flagellum-dependent cell motility (GO:0001539)18.6785232
196cilium movement (GO:0003341)16.0363630
197motile cilium assembly (GO:0044458)14.8115077
198epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.3660400
199epithelial cilium movement (GO:0003351)13.6510141
200axoneme assembly (GO:0035082)10.1501828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.85724798
2EZH2_22144423_ChIP-Seq_EOC_Human4.64803727
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.13224043
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.53019359
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.22263403
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17684428
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10631546
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.96670801
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.87301539
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85560235
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80838752
12GBX2_23144817_ChIP-Seq_PC3_Human2.80388780
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74654312
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68825807
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68825807
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65723045
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62563789
18DROSHA_22980978_ChIP-Seq_HELA_Human2.60305463
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.60105159
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57633330
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50050623
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.49123271
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38058687
24AR_21572438_ChIP-Seq_LNCaP_Human2.37059652
25ESR1_20079471_ChIP-ChIP_T-47D_Human2.36062448
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.34306825
27REST_21632747_ChIP-Seq_MESCs_Mouse2.30863626
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.19713773
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18747190
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11693892
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06670364
32RARB_27405468_Chip-Seq_BRAIN_Mouse2.04005040
33ESR1_21235772_ChIP-Seq_MCF-7_Human2.01419282
34VDR_22108803_ChIP-Seq_LS180_Human1.98814571
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.96651650
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.89983128
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.84568426
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.84559715
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82893730
40TP63_23658742_ChIP-Seq_EP156T_Human1.82529900
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.81785925
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.75804940
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.72223984
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71530720
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69001816
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65644168
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.61991766
48STAT1_20625510_ChIP-Seq_HELA_Human1.60629639
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59031642
50KLF5_25053715_ChIP-Seq_YYC3_Human1.58518583
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.58333546
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56486920
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.54950635
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54063008
55SMC4_20622854_ChIP-Seq_HELA_Human1.53770870
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53628463
57SOX2_20726797_ChIP-Seq_SW620_Human1.52906192
58SMAD4_21799915_ChIP-Seq_A2780_Human1.50986247
59RXR_22108803_ChIP-Seq_LS180_Human1.47088859
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45713758
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44812940
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43392228
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42995055
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41750675
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41101773
66TP63_22573176_ChIP-Seq_HFKS_Human1.41003201
67ETV1_20927104_ChIP-Seq_GIST48_Human1.40490742
68P300_19829295_ChIP-Seq_ESCs_Human1.39167750
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.38902690
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38413419
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.37975282
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.37636128
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37441457
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.36373862
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.36346513
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35861221
77RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35221623
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34828268
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33944623
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33790002
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33483706
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33015859
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32658357
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32282832
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.31186602
86SMRT_27268052_Chip-Seq_Bcells_Human1.30015086
87HNFA_21074721_ChIP-Seq_CACO-2_Human1.28794678
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28344658
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26902642
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26748032
91AR_25329375_ChIP-Seq_VCAP_Human1.26303891
92PHF8_20622853_ChIP-Seq_HELA_Human1.25705002
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25596010
94GATA1_19941826_ChIP-Seq_K562_Human1.24828439
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24688226
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24185131
97GATA4_25053715_ChIP-Seq_YYC3_Human1.24030044
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.22905039
99AR_19668381_ChIP-Seq_PC3_Human1.21922483
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.21610697
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21250132
102TP53_16413492_ChIP-PET_HCT116_Human1.20757542
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20573648
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.20022563
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19565745
106GATA3_24758297_ChIP-Seq_MCF-7_Human1.16966529
107BCAT_22108803_ChIP-Seq_LS180_Human1.16719585
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15770150
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15477112
110STAT3_23295773_ChIP-Seq_U87_Human1.15203996
111RBPJ_21746931_ChIP-Seq_IB4_Human1.14457548
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12494118
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11849340
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11476993
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11213780
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.10960563
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10706725
118NFYA_21822215_ChIP-Seq_K562_Human1.10156163
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.09895392
120CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09243881
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.08852817
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.08201945
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08200995
124FOXA2_19822575_ChIP-Seq_HepG2_Human1.07641160
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06957379
126CEBPB_22108803_ChIP-Seq_LS180_Human1.05346731
127TP53_18474530_ChIP-ChIP_U2OS_Human1.05018317
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04879585
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04702965
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04566000
131GATA6_21074721_ChIP-Seq_CACO-2_Human1.03414861
132RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03139767
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02753798
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02589460
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01980786
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01912379
137NFYB_21822215_ChIP-Seq_K562_Human1.00847138
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00098386
139GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99115350
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.98697889
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.98350984
142CTCF_20526341_ChIP-Seq_ESCs_Human0.98196261
143ZNF274_21170338_ChIP-Seq_K562_Hela0.97922679
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97483845
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97217462
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97085629
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96603686
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96582966
149AHR_22903824_ChIP-Seq_MCF-7_Human0.96054199
150TBL1_22424771_ChIP-Seq_293T_Human0.95686254
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95024756
152TCF4_23295773_ChIP-Seq_U87_Human0.94357054
153CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92814935
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.91271092
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91139517
156TP63_17297297_ChIP-ChIP_HaCaT_Human0.90967490
157RUNX2_22187159_ChIP-Seq_PCA_Human0.90630572
158EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90325826
159EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90064057
160TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89641261
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88662825
162TCF4_22108803_ChIP-Seq_LS180_Human0.87471438
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87411017
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.87074260
165CREB1_26743006_Chip-Seq_LNCaP_Human0.86734523
166TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86468900
167RACK7_27058665_Chip-Seq_MCF-7_Human0.86145590
168TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86144994
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85781219
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85781219
171GATA2_19941826_ChIP-Seq_K562_Human0.84903540
172CTCF_27219007_Chip-Seq_Bcells_Human0.84687171
173ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84224569
174P68_20966046_ChIP-Seq_HELA_Human0.84075383
175PHF8_20622854_ChIP-Seq_HELA_Human0.83442026
176P300_27268052_Chip-Seq_Bcells_Human0.83127475
177FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83094967
178FOXA1_25329375_ChIP-Seq_VCAP_Human0.83094967
179RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83047686
180SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82518503
181SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82002071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.63135636
2MP0002132_abnormal_respiratory_system5.33974886
3MP0004859_abnormal_synaptic_plasticity5.12662128
4MP0004043_abnormal_pH_regulation4.10963517
5MP0003880_abnormal_central_pattern3.79952835
6MP0003635_abnormal_synaptic_transmissio3.48144849
7MP0005646_abnormal_pituitary_gland3.45108185
8MP0002277_abnormal_respiratory_mucosa3.42694286
9MP0004133_heterotaxia3.40140332
10MP0004858_abnormal_nervous_system3.21618567
11MP0003690_abnormal_glial_cell3.06841274
12MP0009780_abnormal_chondrocyte_physiolo3.06225266
13MP0008789_abnormal_olfactory_epithelium2.89834288
14MP0009046_muscle_twitch2.87329451
15MP0002064_seizures2.79393819
16MP0009745_abnormal_behavioral_response2.77153986
17MP0002063_abnormal_learning/memory/cond2.66642944
18MP0001486_abnormal_startle_reflex2.64047331
19MP0000383_abnormal_hair_follicle2.63492689
20MP0004270_analgesia2.55649061
21MP0003329_amyloid_beta_deposits2.52326802
22MP0003136_yellow_coat_color2.47002216
23MP0001440_abnormal_grooming_behavior2.44872893
24MP0004885_abnormal_endolymph2.40843656
25MP0002572_abnormal_emotion/affect_behav2.37432532
26MP0010678_abnormal_skin_adnexa2.32768155
27MP0002168_other_aberrant_phenotype2.23765953
28MP0002282_abnormal_trachea_morphology2.22437985
29MP0005423_abnormal_somatic_nervous2.18811518
30MP0001968_abnormal_touch/_nociception2.18508779
31MP0002272_abnormal_nervous_system2.16290049
32MP0004019_abnormal_vitamin_homeostasis2.11392186
33MP0008569_lethality_at_weaning2.09646295
34MP0003656_abnormal_erythrocyte_physiolo1.99944134
35MP0001501_abnormal_sleep_pattern1.99581951
36MP0000778_abnormal_nervous_system1.94059905
37MP0002734_abnormal_mechanical_nocicepti1.90790069
38MP0002160_abnormal_reproductive_system1.89099537
39MP0002254_reproductive_system_inflammat1.88445092
40MP0002736_abnormal_nociception_after1.85413466
41MP0002557_abnormal_social/conspecific_i1.82825580
42MP0000678_abnormal_parathyroid_gland1.79974582
43MP0005083_abnormal_biliary_tract1.79176836
44MP0002067_abnormal_sensory_capabilities1.79098047
45MP0001502_abnormal_circadian_rhythm1.78563919
46MP0003634_abnormal_glial_cell1.72159276
47MP0009384_cardiac_valve_regurgitation1.71826689
48MP0001346_abnormal_lacrimal_gland1.64445499
49MP0003950_abnormal_plasma_membrane1.64060156
50MP0005394_taste/olfaction_phenotype1.64010611
51MP0005499_abnormal_olfactory_system1.64010611
52MP0001765_abnormal_ion_homeostasis1.63194389
53MP0002733_abnormal_thermal_nociception1.56757844
54MP0005165_increased_susceptibility_to1.55558194
55MP0010234_abnormal_vibrissa_follicle1.51418835
56MP0001984_abnormal_olfaction1.48912223
57MP0002909_abnormal_adrenal_gland1.46747212
58MP0005395_other_phenotype1.46409915
59MP0000955_abnormal_spinal_cord1.45086290
60MP0005645_abnormal_hypothalamus_physiol1.44914316
61MP0003633_abnormal_nervous_system1.42069788
62MP0004142_abnormal_muscle_tone1.41233403
63MP0005386_behavior/neurological_phenoty1.39585942
64MP0004924_abnormal_behavior1.39585942
65MP0001970_abnormal_pain_threshold1.38841868
66MP0010030_abnormal_orbit_morphology1.38581055
67MP0002653_abnormal_ependyma_morphology1.38280151
68MP0002882_abnormal_neuron_morphology1.37965565
69MP0005408_hypopigmentation1.35455343
70MP0003075_altered_response_to1.32939171
71MP0001485_abnormal_pinna_reflex1.32023965
72MP0003632_abnormal_nervous_system1.31500828
73MP0003631_nervous_system_phenotype1.28988750
74MP0002184_abnormal_innervation1.24930684
75MP0004811_abnormal_neuron_physiology1.24823071
76MP0000566_synostosis1.22138768
77MP0000604_amyloidosis1.22057966
78MP0002066_abnormal_motor_capabilities/c1.20480893
79MP0002152_abnormal_brain_morphology1.20249044
80MP0000465_gastrointestinal_hemorrhage1.17180418
81MP0010155_abnormal_intestine_physiology1.16651626
82MP0004215_abnormal_myocardial_fiber1.15209648
83MP0000920_abnormal_myelination1.14625391
84MP0002638_abnormal_pupillary_reflex1.11764981
85MP0002735_abnormal_chemical_nociception1.09857021
86MP0005167_abnormal_blood-brain_barrier1.09494851
87MP0005248_abnormal_Harderian_gland1.09327499
88MP0005551_abnormal_eye_electrophysiolog1.08763215
89MP0000631_abnormal_neuroendocrine_gland1.07942244
90MP0003279_aneurysm1.07820598
91MP0005623_abnormal_meninges_morphology1.06790076
92MP0005636_abnormal_mineral_homeostasis1.04855278
93MP0004742_abnormal_vestibular_system1.03362593
94MP0003806_abnormal_nucleotide_metabolis1.03147936
95MP0003137_abnormal_impulse_conducting1.02832463
96MP0002233_abnormal_nose_morphology0.99216347
97MP0002822_catalepsy0.97260755
98MP0003938_abnormal_ear_development0.96923102
99MP0001177_atelectasis0.95910247
100MP0000681_abnormal_thyroid_gland0.95234042
101MP0005164_abnormal_response_to0.94371646
102MP0003879_abnormal_hair_cell0.93069135
103MP0002876_abnormal_thyroid_physiology0.92764574
104MP0006072_abnormal_retinal_apoptosis0.92725930
105MP0001963_abnormal_hearing_physiology0.91647820
106MP0002090_abnormal_vision0.91555327
107MP0001879_abnormal_lymphatic_vessel0.90603400
108MP0002229_neurodegeneration0.88588329
109MP0005253_abnormal_eye_physiology0.88286882
110MP0002098_abnormal_vibrissa_morphology0.87195446
111MP0000049_abnormal_middle_ear0.86829623
112MP0005503_abnormal_tendon_morphology0.86243848
113MP0000026_abnormal_inner_ear0.85773820
114MP0006276_abnormal_autonomic_nervous0.83396541
115MP0001905_abnormal_dopamine_level0.83187479
116MP0003183_abnormal_peptide_metabolism0.82825988
117MP0005389_reproductive_system_phenotype0.81255524
118MP0004130_abnormal_muscle_cell0.80714197
119MP0001299_abnormal_eye_distance/0.79855108
120MP0004264_abnormal_extraembryonic_tissu0.79840072
121MP0003122_maternal_imprinting0.79079590
122MP0002136_abnormal_kidney_physiology0.78406566
123MP0002249_abnormal_larynx_morphology0.78386330
124MP0003453_abnormal_keratinocyte_physiol0.78001457
125MP0009643_abnormal_urine_homeostasis0.77824751
126MP0004883_abnormal_blood_vessel0.77565709
127MP0001849_ear_inflammation0.77500032
128MP0002752_abnormal_somatic_nervous0.75889909
129MP0006292_abnormal_olfactory_placode0.75400768
130MP0005310_abnormal_salivary_gland0.72143189
131MP0000751_myopathy0.71980508
132MP0005365_abnormal_bile_salt0.71399282
133MP0000467_abnormal_esophagus_morphology0.71263732
134MP0002069_abnormal_eating/drinking_beha0.71080953
135MP0001324_abnormal_eye_pigmentation0.70790517
136MP0005377_hearing/vestibular/ear_phenot0.70520369
137MP0003878_abnormal_ear_physiology0.70520369
138MP0001929_abnormal_gametogenesis0.70175698
139MP0005085_abnormal_gallbladder_physiolo0.69982759
140MP0001270_distended_abdomen0.67760980
141MP0003861_abnormal_nervous_system0.67127148
142MP0003698_abnormal_male_reproductive0.66869515
143MP0001529_abnormal_vocalization0.66657856
144MP0000858_altered_metastatic_potential0.66602681
145MP0005220_abnormal_exocrine_pancreas0.65541530
146MP0003011_delayed_dark_adaptation0.65208294
147MP0005023_abnormal_wound_healing0.65115267
148MP0002896_abnormal_bone_mineralization0.64862762
149MP0001293_anophthalmia0.63668647
150MP0002405_respiratory_system_inflammati0.63323434
151MP0002089_abnormal_postnatal_growth/wei0.63108360
152MP0004085_abnormal_heartbeat0.63107250
153MP0003566_abnormal_cell_adhesion0.62766334
154MP0004145_abnormal_muscle_electrophysio0.62730693
155MP0005595_abnormal_vascular_smooth0.62372411
156MP0008872_abnormal_physiological_respon0.62093816
157MP0004233_abnormal_muscle_weight0.61475472
158MP0000428_abnormal_craniofacial_morphol0.60699196
159MP0003942_abnormal_urinary_system0.60150147
160MP0009765_abnormal_xenobiotic_induced0.59170939
161MP0009703_decreased_birth_body0.57175261
162MP0003937_abnormal_limbs/digits/tail_de0.55113096
163MP0005388_respiratory_system_phenotype0.54532856
164MP0002133_abnormal_respiratory_system0.54532856
165MP0003303_peritoneal_inflammation0.54224603
166MP0009763_increased_sensitivity_to0.53966641
167MP0002116_abnormal_craniofacial_bone0.53017381
168MP0001664_abnormal_digestion0.51814548
169MP0010368_abnormal_lymphatic_system0.50928361
170MP0009053_abnormal_anal_canal0.47800056
171MP0002084_abnormal_developmental_patter0.46715011
172MP0003941_abnormal_skin_development0.45962638
173MP0005195_abnormal_posterior_eye0.43366086
174MP0002796_impaired_skin_barrier0.41310204
175MP0003045_fibrosis0.41000109
176MP0003890_abnormal_embryonic-extraembry0.40944010
177MP0005391_vision/eye_phenotype0.40675891
178MP0001663_abnormal_digestive_system0.40250783

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.90276356
2Bronchiectasis (HP:0002110)7.42739665
3Nasal polyposis (HP:0100582)6.76717418
4Aplasia involving bones of the upper limbs (HP:0009823)6.32513743
5Aplasia of the phalanges of the hand (HP:0009802)6.32513743
6Aplasia involving bones of the extremities (HP:0009825)6.32513743
7Abnormality of the nasal mucosa (HP:0000433)5.68291020
8Megalencephaly (HP:0001355)5.07960589
9Focal motor seizures (HP:0011153)4.90674572
10Myokymia (HP:0002411)4.52093474
11Bronchitis (HP:0012387)4.38266354
12Recurrent sinusitis (HP:0011108)4.32138588
13Infertility (HP:0000789)4.14543990
14Chronic sinusitis (HP:0011109)4.09933183
15Male infertility (HP:0003251)3.95894729
16Recurrent otitis media (HP:0000403)3.87139797
17Neurofibrillary tangles (HP:0002185)3.80857411
18Action tremor (HP:0002345)3.67380561
19Occipital encephalocele (HP:0002085)3.64373684
20Focal seizures (HP:0007359)3.61608041
21Progressive cerebellar ataxia (HP:0002073)3.49014851
22Abnormality of binocular vision (HP:0011514)3.39550534
23Diplopia (HP:0000651)3.39550534
24Epileptic encephalopathy (HP:0200134)3.31854707
25Visual hallucinations (HP:0002367)3.31818324
26Hemiparesis (HP:0001269)3.20911558
27Humeroradial synostosis (HP:0003041)3.14651297
28Synostosis involving the elbow (HP:0003938)3.14651297
29Long nose (HP:0003189)3.09109730
30Chronic otitis media (HP:0000389)3.08052553
31Supranuclear gaze palsy (HP:0000605)3.05913868
32Dysdiadochokinesis (HP:0002075)3.05268423
33Hyperactive renin-angiotensin system (HP:0000841)3.01350559
34Cerebral inclusion bodies (HP:0100314)2.97567248
35Abnormal ciliary motility (HP:0012262)2.97401966
36Abnormality of the middle phalanges of the toes (HP:0010183)2.97257634
37Cystic liver disease (HP:0006706)2.88426534
38Atelectasis (HP:0100750)2.88384662
39Abnormality of midbrain morphology (HP:0002418)2.86897757
40Molar tooth sign on MRI (HP:0002419)2.86897757
41Abnormal respiratory motile cilium physiology (HP:0012261)2.82663687
42Pancreatic cysts (HP:0001737)2.82313426
43Hemiplegia (HP:0002301)2.79555778
44Postural instability (HP:0002172)2.77588338
45Short hallux (HP:0010109)2.76197045
46Hypoplastic left heart (HP:0004383)2.74647109
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.67922741
48Nephronophthisis (HP:0000090)2.66288135
49Aplasia/Hypoplasia of the hallux (HP:0008362)2.66269622
50Abnormal eating behavior (HP:0100738)2.64322020
51Ankle clonus (HP:0011448)2.56419912
52Intention tremor (HP:0002080)2.50024270
53Postaxial foot polydactyly (HP:0001830)2.45938385
54Depression (HP:0000716)2.43063859
55Chronic hepatic failure (HP:0100626)2.43000354
56Bronchomalacia (HP:0002780)2.39230551
57Generalized tonic-clonic seizures (HP:0002069)2.37725421
58Genetic anticipation (HP:0003743)2.37006714
59Narrow nasal bridge (HP:0000446)2.36561463
60Dysmetria (HP:0001310)2.30190752
61True hermaphroditism (HP:0010459)2.28111766
62Atonic seizures (HP:0010819)2.25315531
63Absence seizures (HP:0002121)2.24002959
64Tubulointerstitial nephritis (HP:0001970)2.23902595
65Mixed hearing impairment (HP:0000410)2.23270409
66Clumsiness (HP:0002312)2.23062695
67Dialeptic seizures (HP:0011146)2.22199065
68Status epilepticus (HP:0002133)2.21932359
69Maternal diabetes (HP:0009800)2.21854903
70Anxiety (HP:0000739)2.21170230
71Febrile seizures (HP:0002373)2.20296522
72Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.18087164
73Rhinitis (HP:0012384)2.16385346
74Truncal ataxia (HP:0002078)2.16362091
75Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.15821892
76Abnormality of the proximal phalanges of the hand (HP:0009834)2.14646233
77Absent/shortened dynein arms (HP:0200106)2.13301144
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.13301144
79Bell-shaped thorax (HP:0001591)2.13072919
80Broad alveolar ridges (HP:0000187)2.11914686
81Cutaneous syndactyly (HP:0012725)2.11831339
82Abnormal respiratory motile cilium morphology (HP:0005938)2.10818529
83Abnormal respiratory epithelium morphology (HP:0012253)2.10818529
84Hyperventilation (HP:0002883)2.09442073
85Congenital hepatic fibrosis (HP:0002612)2.09400562
86Abnormality of the renal medulla (HP:0100957)2.07584037
87Lower limb muscle weakness (HP:0007340)2.07342966
88Scanning speech (HP:0002168)2.05977996
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.05414833
90Impaired vibration sensation in the lower limbs (HP:0002166)2.01816783
91Absent frontal sinuses (HP:0002688)2.01138834
92Abnormality of the dental pulp (HP:0006479)2.00130832
93Hypoplastic heart (HP:0001961)1.98628583
94Adactyly (HP:0009776)1.97693211
95Abnormality of the phalanges of the 5th finger (HP:0004213)1.96583728
96Recurrent bronchitis (HP:0002837)1.96259477
97Anencephaly (HP:0002323)1.95442608
98Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93987258
99Urinary urgency (HP:0000012)1.92510859
100Short middle phalanx of the 5th finger (HP:0004220)1.91584114
101Urinary bladder sphincter dysfunction (HP:0002839)1.90910132
102Medial flaring of the eyebrow (HP:0010747)1.88840553
103Split foot (HP:0001839)1.88003004
104Gaze-evoked nystagmus (HP:0000640)1.87406173
105Broad-based gait (HP:0002136)1.86926740
106Male pseudohermaphroditism (HP:0000037)1.86568484
107Abnormality of the columella (HP:0009929)1.86111408
108Atrioventricular block (HP:0001678)1.84109543
109Median cleft lip (HP:0000161)1.81411647
110Abnormality of permanent molar morphology (HP:0011071)1.80187655
111Abnormality of the dental root (HP:0006486)1.80187655
112Taurodontia (HP:0000679)1.80187655
113Peripheral hypomyelination (HP:0007182)1.79991583
114Symphalangism affecting the phalanges of the hand (HP:0009773)1.79960189
115Neonatal short-limb short stature (HP:0008921)1.79497419
116Renal salt wasting (HP:0000127)1.79290206
117Decreased circulating renin level (HP:0003351)1.78603848
118Bradykinesia (HP:0002067)1.77520296
119Impaired smooth pursuit (HP:0007772)1.76973986
120Furrowed tongue (HP:0000221)1.75742193
121Increased circulating renin level (HP:0000848)1.75198272
122Pancreatic fibrosis (HP:0100732)1.73798594
123Congenital primary aphakia (HP:0007707)1.73169311
124Polyphagia (HP:0002591)1.72988824
125Tetraparesis (HP:0002273)1.72235807
126Morphological abnormality of the inner ear (HP:0011390)1.71972684
127Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70908242
128Confusion (HP:0001289)1.70573093
129Hyperkalemia (HP:0002153)1.69903397
130Pheochromocytoma (HP:0002666)1.69529155
131Gait imbalance (HP:0002141)1.69485661
132Sclerocornea (HP:0000647)1.68575151
133Heart block (HP:0012722)1.68113187
134Postural tremor (HP:0002174)1.67974515
135Abnormality of ocular smooth pursuit (HP:0000617)1.67673561
136Oculomotor apraxia (HP:0000657)1.67437983
137Tubular atrophy (HP:0000092)1.67417746
138Abnormality of the middle phalanges of the hand (HP:0009833)1.67048550
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.66054797
140Abnormality of chromosome segregation (HP:0002916)1.65543716
141Abnormality of molar (HP:0011077)1.65510664
142Asplenia (HP:0001746)1.65433445
143Nephropathy (HP:0000112)1.58326484
144Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.55597710
145Postaxial hand polydactyly (HP:0001162)1.52737132
146Short nail (HP:0001799)1.50556102
147Hyperaldosteronism (HP:0000859)1.47806488
148Nephrogenic diabetes insipidus (HP:0009806)1.47555852
149Glucose intolerance (HP:0000833)1.39824986
150Abnormality of chloride homeostasis (HP:0011422)1.35462681
151Abnormality of the distal phalanges of the toes (HP:0010182)1.32164205
152Preaxial hand polydactyly (HP:0001177)1.32083671
153Short thorax (HP:0010306)1.31178675
154Abnormality of renin-angiotensin system (HP:0000847)1.30237362
155Absent rod-and cone-mediated responses on ERG (HP:0007688)1.26771439
156Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.25817399
157Decreased central vision (HP:0007663)1.25623236
158Hand muscle atrophy (HP:0009130)1.25576492
159Tubulointerstitial abnormality (HP:0001969)1.24306153
160Abnormality of the frontal sinuses (HP:0002687)1.22603380
161Cone-rod dystrophy (HP:0000548)1.21419236
162Hypokalemic alkalosis (HP:0001949)1.20878572
163Bifid scrotum (HP:0000048)1.17146156
164Poor coordination (HP:0002370)1.17009264
165Abnormality of molar morphology (HP:0011070)1.16071573
166Stage 5 chronic kidney disease (HP:0003774)1.15393468
167Lip pit (HP:0100267)1.13889325
168Genital tract atresia (HP:0001827)1.12977075
169Vaginal atresia (HP:0000148)1.12759893
170Spinal cord compression (HP:0002176)1.12111390
171Short femoral neck (HP:0100864)1.09801925
172Hyponatremia (HP:0002902)1.08738516
173Abnormality of dentin (HP:0010299)1.08449835
174Abnormality of monocarboxylic acid metabolism (HP:0010996)1.06842417
175Vascular calcification (HP:0004934)1.06814756
176Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.04363827
177Supernumerary spleens (HP:0009799)1.02321980
178Spinal muscular atrophy (HP:0007269)1.02241516
179Broad distal phalanx of finger (HP:0009836)1.02169137
180Flat acetabular roof (HP:0003180)0.99100277
181Cardiovascular calcification (HP:0011915)0.97912419
182Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.97818708
183Limb-girdle muscle atrophy (HP:0003797)0.97532841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.58140789
2EPHA25.48202095
3EPHA44.12300856
4NTRK23.80028123
5NTRK33.21017188
6LMTK23.16440949
7MAPKAPK32.80197400
8PHKG22.71703046
9PHKG12.71703046
10TNIK2.56983035
11MAP3K42.30583163
12PRKD32.29854231
13SMG12.27723415
14CASK2.21729777
15MARK12.21597480
16MAP3K92.14079240
17MAP2K72.11897525
18STK242.04822312
19NTRK12.00158642
20MINK11.99163986
21TTK1.86705456
22PNCK1.75338927
23PAK61.75172967
24MAP3K31.73836739
25SGK21.73089662
26EEF2K1.69369955
27NEK61.65839595
28SGK2231.64842978
29SGK4941.64842978
30SIK11.60802189
31CAMKK11.55556563
32KSR11.54852224
33TYRO31.54037971
34DAPK21.53854911
35SGK31.48208209
36PRKCG1.45220271
37BCR1.43842284
38CSK1.42943334
39MST1R1.42883447
40MAPK131.41626113
41TRPM71.33872704
42PRPF4B1.29028100
43CDK51.28273371
44TRIB31.26425772
45STK101.25071624
46MAP2K41.24410787
47TESK11.24038609
48KSR21.20308185
49CAMKK21.15055446
50PINK11.13666597
51EPHB11.12614685
52UHMK11.10247932
53STK381.08585999
54PBK1.08002318
55MAPK121.05085901
56LRRK20.96516094
57PAK30.95880707
58FGFR20.93597240
59ROCK20.93289066
60ERBB30.92949041
61MAP3K20.92778602
62MAP3K70.92069154
63TLK10.88781127
64CDK180.86088583
65MAPK150.84958037
66FRK0.84941473
67CDK150.83936838
68DYRK1A0.83509886
69MAPK70.83289848
70CAMK2A0.82859426
71ROCK10.81713694
72BRSK20.81663593
73SIK30.79299397
74STK110.79068682
75FES0.78887083
76LATS20.78855193
77MAP3K120.78709469
78PRKCH0.78034953
79CAMK2B0.77972202
80PLK20.76697751
81PRKCI0.76566055
82CDK140.73212467
83SGK10.72518119
84ICK0.72414493
85SIK20.71505642
86CDK11A0.71118095
87TBK10.71023724
88FGR0.69619799
89IRAK10.69433134
90GRK50.69421738
91EPHA30.68565741
92NEK90.65341413
93PRKCE0.64557507
94BMX0.63763519
95CAMK1G0.63561496
96CDK190.58620875
97CAMK10.57744503
98RPS6KB20.57217790
99CAMK2G0.56094107
100MET0.55930079
101LIMK10.55506569
102MAP3K130.55195263
103MUSK0.55007453
104ACVR1B0.54187155
105RPS6KA30.53934431
106CDK30.51906880
107AURKA0.51897924
108RET0.50244539
109PRKAA20.49429450
110PTK2B0.48886307
111DAPK10.48372218
112ALK0.48208813
113DMPK0.47656014
114CDC42BPA0.47399239
115BRSK10.46035833
116NME10.44915308
117STK38L0.44368567
118MARK20.44086147
119RIPK40.43659523
120IRAK20.42891079
121FER0.42635603
122CAMK2D0.42566463
123PRKCZ0.42143884
124GRK10.41236851
125FYN0.41114321
126PKN10.41061224
127MAPK100.40645190
128PRKCD0.39268394
129WNK10.38272411
130PDPK10.38253616
131ERBB20.37452804
132SRC0.37435738
133PDK10.36810559
134PRKCA0.35778463
135PRKACG0.34833197
136RIPK10.34819504
137ERBB40.34586916
138ADRBK10.34573227
139OXSR10.34103730
140DDR20.33901477
141PRKCQ0.33098513
142LATS10.32921676
143MELK0.32320706
144MAPKAPK50.31924892
145HIPK20.31501036
146NLK0.29431081
147MYLK0.27751092
148ABL10.26414365
149STK160.26019509
150PAK40.25199894
151MAP2K10.24151869
152CHEK20.23111474
153PTK20.22932678
154PAK10.22779999
155BMPR1B0.22626980
156PLK10.22123326
157CDK60.21829339
158TSSK60.20823393
159FGFR30.19233029
160GRK60.17409390
161STK390.15873378
162PRKACA0.15668818
163AKT20.13041860
164EGFR0.12731896
165CDK90.12657446
166ILK0.12161194
167TGFBR10.11091607
168ZAP700.10967409
169TYK20.10522338

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.82431441
2Phenylalanine metabolism_Homo sapiens_hsa003605.00968369
3Histidine metabolism_Homo sapiens_hsa003404.94370825
4Nitrogen metabolism_Homo sapiens_hsa009104.93440656
5Chemical carcinogenesis_Homo sapiens_hsa052044.74536209
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.49556245
7Tyrosine metabolism_Homo sapiens_hsa003504.10877624
8beta-Alanine metabolism_Homo sapiens_hsa004103.28440425
9Nicotine addiction_Homo sapiens_hsa050333.18749869
10Glutathione metabolism_Homo sapiens_hsa004802.82016825
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.75455321
12GABAergic synapse_Homo sapiens_hsa047272.52729521
13Huntingtons disease_Homo sapiens_hsa050162.51276924
14Glutamatergic synapse_Homo sapiens_hsa047242.49527494
15Retinol metabolism_Homo sapiens_hsa008302.40220883
16Synaptic vesicle cycle_Homo sapiens_hsa047212.23614170
17Fatty acid biosynthesis_Homo sapiens_hsa000612.23600226
18Circadian entrainment_Homo sapiens_hsa047132.21448989
19Caffeine metabolism_Homo sapiens_hsa002322.17826702
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06412531
21Gastric acid secretion_Homo sapiens_hsa049712.04003636
22Olfactory transduction_Homo sapiens_hsa047402.03921294
23Salivary secretion_Homo sapiens_hsa049702.01563254
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94697716
25Morphine addiction_Homo sapiens_hsa050321.93868117
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.89933012
27Insulin secretion_Homo sapiens_hsa049111.89752892
28Long-term potentiation_Homo sapiens_hsa047201.86559367
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80658725
30Amphetamine addiction_Homo sapiens_hsa050311.77429781
31Linoleic acid metabolism_Homo sapiens_hsa005911.65992171
32ABC transporters_Homo sapiens_hsa020101.58942286
33Cocaine addiction_Homo sapiens_hsa050301.56764955
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.50760969
35Dopaminergic synapse_Homo sapiens_hsa047281.43912163
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43225278
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37298492
38Tight junction_Homo sapiens_hsa045301.35426041
39Cholinergic synapse_Homo sapiens_hsa047251.34521743
40Calcium signaling pathway_Homo sapiens_hsa040201.33601001
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33291202
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31898601
43Dorso-ventral axis formation_Homo sapiens_hsa043201.31044765
44Long-term depression_Homo sapiens_hsa047301.30177509
45Renin secretion_Homo sapiens_hsa049241.24338556
46Circadian rhythm_Homo sapiens_hsa047101.24296773
47Taste transduction_Homo sapiens_hsa047421.24087332
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22426261
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18433585
50cAMP signaling pathway_Homo sapiens_hsa040241.17989779
51Gap junction_Homo sapiens_hsa045401.17371869
52Serotonergic synapse_Homo sapiens_hsa047261.16901115
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15375747
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09237550
55Oxytocin signaling pathway_Homo sapiens_hsa049211.07662707
56Bile secretion_Homo sapiens_hsa049761.02770427
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99656016
58Peroxisome_Homo sapiens_hsa041460.98971428
59GnRH signaling pathway_Homo sapiens_hsa049120.98602891
60Melanogenesis_Homo sapiens_hsa049160.97141018
61Arachidonic acid metabolism_Homo sapiens_hsa005900.95939608
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94856847
63Estrogen signaling pathway_Homo sapiens_hsa049150.92678325
64Fatty acid metabolism_Homo sapiens_hsa012120.92479969
65Starch and sucrose metabolism_Homo sapiens_hsa005000.91604701
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.91100690
67Axon guidance_Homo sapiens_hsa043600.89381479
68Butanoate metabolism_Homo sapiens_hsa006500.87505969
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86250800
70Cardiac muscle contraction_Homo sapiens_hsa042600.84980245
71Pancreatic secretion_Homo sapiens_hsa049720.84672239
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83445690
73Thyroid hormone synthesis_Homo sapiens_hsa049180.81564341
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80803275
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.80731633
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80621359
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76702763
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76456761
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76432764
80Glioma_Homo sapiens_hsa052140.74978259
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73831291
82Mineral absorption_Homo sapiens_hsa049780.73559538
83Adherens junction_Homo sapiens_hsa045200.73470035
84ErbB signaling pathway_Homo sapiens_hsa040120.73115090
85Type II diabetes mellitus_Homo sapiens_hsa049300.72861967
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72079448
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67074127
88Collecting duct acid secretion_Homo sapiens_hsa049660.66465635
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65037928
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.64871099
91Dilated cardiomyopathy_Homo sapiens_hsa054140.61777498
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.61518111
93Glucagon signaling pathway_Homo sapiens_hsa049220.59299987
94Choline metabolism in cancer_Homo sapiens_hsa052310.58614941
95Hepatitis C_Homo sapiens_hsa051600.57720813
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57639178
97Arginine biosynthesis_Homo sapiens_hsa002200.57327997
98Notch signaling pathway_Homo sapiens_hsa043300.55993619
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54941350
100PPAR signaling pathway_Homo sapiens_hsa033200.53246701
101Prion diseases_Homo sapiens_hsa050200.53201901
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51504511
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.50298804
104Basal cell carcinoma_Homo sapiens_hsa052170.49315396
105Wnt signaling pathway_Homo sapiens_hsa043100.48646257
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47815394
107MAPK signaling pathway_Homo sapiens_hsa040100.46947248
108Phototransduction_Homo sapiens_hsa047440.46712789
109Fatty acid degradation_Homo sapiens_hsa000710.46246958
110Rap1 signaling pathway_Homo sapiens_hsa040150.44983709
111Complement and coagulation cascades_Homo sapiens_hsa046100.44787925
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.44642188
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44282048
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43670361
115Ras signaling pathway_Homo sapiens_hsa040140.40525718
116Hedgehog signaling pathway_Homo sapiens_hsa043400.40241743
117Vibrio cholerae infection_Homo sapiens_hsa051100.39250559
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.38417155
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37969084
120African trypanosomiasis_Homo sapiens_hsa051430.37717216
121Amoebiasis_Homo sapiens_hsa051460.37445880
122Vitamin B6 metabolism_Homo sapiens_hsa007500.36673273
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.36475678
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36387640
125Propanoate metabolism_Homo sapiens_hsa006400.35464597
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.34512187
127Inositol phosphate metabolism_Homo sapiens_hsa005620.34491398
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34306176
129Hematopoietic cell lineage_Homo sapiens_hsa046400.34201439
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33532065
131Insulin signaling pathway_Homo sapiens_hsa049100.33399901
132Glycerolipid metabolism_Homo sapiens_hsa005610.32783533
133Sphingolipid metabolism_Homo sapiens_hsa006000.32236154
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31966436
135Type I diabetes mellitus_Homo sapiens_hsa049400.31923794
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.31402495
137Hippo signaling pathway_Homo sapiens_hsa043900.29734229
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29584726
139Lysosome_Homo sapiens_hsa041420.29027204
140Arginine and proline metabolism_Homo sapiens_hsa003300.28066620
141Metabolic pathways_Homo sapiens_hsa011000.27741564
142Oocyte meiosis_Homo sapiens_hsa041140.27247855
143Tryptophan metabolism_Homo sapiens_hsa003800.26668621
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24694522
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19072005
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.19060119
147Insulin resistance_Homo sapiens_hsa049310.16625152
148Ovarian steroidogenesis_Homo sapiens_hsa049130.13029908
149Pyruvate metabolism_Homo sapiens_hsa006200.11729135
150Endocytosis_Homo sapiens_hsa041440.11691734
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.10567462
152ECM-receptor interaction_Homo sapiens_hsa045120.08992908
153N-Glycan biosynthesis_Homo sapiens_hsa005100.08911472
154Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.07610996
155Prostate cancer_Homo sapiens_hsa052150.06890867
156Proteoglycans in cancer_Homo sapiens_hsa052050.04266613
157Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03428057
158p53 signaling pathway_Homo sapiens_hsa041150.03142999
159Vitamin digestion and absorption_Homo sapiens_hsa049770.02903666

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »