ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.37504768
2	male meiosis (GO:0007140)	4.86545901
3	positive regulation of catecholamine secretion (GO:0033605)	4.85494619
4	multicellular organism reproduction (GO:0032504)	4.81381105
5	acrosome reaction (GO:0007340)	4.68475123
6	regulation of posttranscriptional gene silencing (GO:0060147)	4.67621118
7	regulation of gene silencing by miRNA (GO:0060964)	4.67621118
8	regulation of gene silencing by RNA (GO:0060966)	4.67621118
9	epithelial cilium movement (GO:0003351)	4.51700892
10	spermatid development (GO:0007286)	4.46500996
11	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.42810962
12	sperm motility (GO:0030317)	4.40730273
13	piRNA metabolic process (GO:0034587)	4.24011993
14	motile cilium assembly (GO:0044458)	4.19339219
15	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.95043274
16	cilium or flagellum-dependent cell motility (GO:0001539)	3.93550460
17	ubiquinone biosynthetic process (GO:0006744)	3.91633266
18	response to pheromone (GO:0019236)	3.85637218
19	amino acid salvage (GO:0043102)	3.83082046
20	L-methionine salvage (GO:0071267)	3.83082046
21	L-methionine biosynthetic process (GO:0071265)	3.83082046
22	activation of protein kinase B activity (GO:0032148)	3.72307127
23	sperm-egg recognition (GO:0035036)	3.69866345
24	tryptophan catabolic process (GO:0006569)	3.69368442
25	indole-containing compound catabolic process (GO:0042436)	3.69368442
26	indolalkylamine catabolic process (GO:0046218)	3.69368442
27	negative regulation of gene silencing (GO:0060969)	3.66015572
28	fatty acid elongation (GO:0030497)	3.65730405
29	organic cation transport (GO:0015695)	3.63389765
30	binding of sperm to zona pellucida (GO:0007339)	3.58249129
31	intra-S DNA damage checkpoint (GO:0031573)	3.54927401
32	cilium movement (GO:0003341)	3.54064026
33	relaxation of smooth muscle (GO:0044557)	3.52234149
34	base-excision repair, AP site formation (GO:0006285)	3.49477091
35	DNA damage response, detection of DNA damage (GO:0042769)	3.49378402
36	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.48838423
37	ubiquinone metabolic process (GO:0006743)	3.47213449
38	preassembly of GPI anchor in ER membrane (GO:0016254)	3.46353352
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.36190950
40	regulation of dopamine secretion (GO:0014059)	3.35600656
41	axonemal dynein complex assembly (GO:0070286)	3.30778675
42	single fertilization (GO:0007338)	3.28025612
43	cell-cell recognition (GO:0009988)	3.27266100
44	DNA double-strand break processing (GO:0000729)	3.25025312
45	L-fucose catabolic process (GO:0042355)	3.23312804
46	fucose catabolic process (GO:0019317)	3.23312804
47	L-fucose metabolic process (GO:0042354)	3.23312804
48	histone H4-K12 acetylation (GO:0043983)	3.22389219
49	DNA integration (GO:0015074)	3.19380865
50	quinone biosynthetic process (GO:1901663)	3.19376526
51	response to nitrosative stress (GO:0051409)	3.15922390
52	reproduction (GO:0000003)	3.15797532
53	intraciliary transport (GO:0042073)	3.14455218
54	regulation of protein kinase A signaling (GO:0010738)	3.12919291
55	mannosylation (GO:0097502)	3.12163004
56	cilium morphogenesis (GO:0060271)	3.10060248
57	cellular ketone body metabolic process (GO:0046950)	3.09658277
58	zinc ion homeostasis (GO:0055069)	3.08036500
59	seminiferous tubule development (GO:0072520)	3.03199167
60	coenzyme catabolic process (GO:0009109)	3.00335936
61	protein polyglutamylation (GO:0018095)	2.97756710
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.96791919
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.96791919
64	serine family amino acid catabolic process (GO:0009071)	2.92757131
65	methionine biosynthetic process (GO:0009086)	2.88178266
66	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.86241802
67	indolalkylamine metabolic process (GO:0006586)	2.82606915
68	gene silencing by RNA (GO:0031047)	2.82301052
69	cellular biogenic amine catabolic process (GO:0042402)	2.82160326
70	amine catabolic process (GO:0009310)	2.82160326
71	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.81433435
72	platelet dense granule organization (GO:0060155)	2.80981222
73	male meiosis I (GO:0007141)	2.78605061
74	cellular zinc ion homeostasis (GO:0006882)	2.77760020
75	synapsis (GO:0007129)	2.74072298
76	regulation of cellular respiration (GO:0043457)	2.74061858
77	androgen biosynthetic process (GO:0006702)	2.72611254
78	regulation of oxidative stress-induced neuron death (GO:1903203)	2.72320918
79	proteasome assembly (GO:0043248)	2.71302056
80	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.70997528
81	membrane tubulation (GO:0097320)	2.69999227
82	ketone body metabolic process (GO:1902224)	2.69633820
83	tongue development (GO:0043586)	2.67378201
84	GPI anchor metabolic process (GO:0006505)	2.65636253
85	regulation of autophagic vacuole assembly (GO:2000785)	2.65278539
86	mitochondrion morphogenesis (GO:0070584)	2.63519479
87	cellular response to zinc ion (GO:0071294)	2.63396649
88	kidney morphogenesis (GO:0060993)	2.62956498
89	tryptophan metabolic process (GO:0006568)	2.62236883
90	rhodopsin mediated signaling pathway (GO:0016056)	2.61877366
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.57853578
92	cilium organization (GO:0044782)	2.57588626
93	myoblast migration (GO:0051451)	2.56852965
94	sulfation (GO:0051923)	2.56787151
95	DNA methylation involved in gamete generation (GO:0043046)	2.56668703
96	estrogen biosynthetic process (GO:0006703)	2.52912103
97	methionine metabolic process (GO:0006555)	2.51069605
98	cilium assembly (GO:0042384)	2.49423104
99	neuromuscular synaptic transmission (GO:0007274)	2.48314505
100	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.48057671

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.43297602
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95839579
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.93699115
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.75958463
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.67429481
6	VDR_22108803_ChIP-Seq_LS180_Human	3.52607036
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.46532496
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.25437158
9	FUS_26573619_Chip-Seq_HEK293_Human	2.80813147
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.53068207
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.48110540
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.42703783
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35912625
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.28846169
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16092029
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.06988629
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05343549
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02719886
19	P300_19829295_ChIP-Seq_ESCs_Human	1.96513275
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.96223578
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79134624
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.75749792
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.69295871
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69295871
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60225254
26	EWS_26573619_Chip-Seq_HEK293_Human	1.58793811
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55397315
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55309748
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.53468526
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46778309
31	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.44765700
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42819128
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41690340
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41690340
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.41383424
36	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40064244
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39881304
38	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.38964125
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36124296
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.34673923
41	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.34438368
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.33080556
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.30241512
44	AR_20517297_ChIP-Seq_VCAP_Human	1.29479750
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28438501
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27903110
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27903110
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26473450
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25405335
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24271691
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24123222
52	AR_25329375_ChIP-Seq_VCAP_Human	1.23333998
53	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22611510
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21125558
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.20673244
56	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.20221189
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18993989
58	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18929331
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18405293
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14292441
61	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.13686170
62	ERA_21632823_ChIP-Seq_H3396_Human	1.13403071
63	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11893950
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10375942
65	STAT3_23295773_ChIP-Seq_U87_Human	1.10240968
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10157536
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.09954615
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09434612
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08399446
70	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.08132615
71	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07225582
72	NCOR_22424771_ChIP-Seq_293T_Human	1.06789150
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06742719
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05385171
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.03678031
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02632143
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02433908
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02420856
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.00877911
80	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00545446
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00398705
82	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99116268
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.98136408
84	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.97726111
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97003659
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96095988
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95155236
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95124128
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94185514
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92510465
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92240988
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92240988
93	RAC3_21632823_ChIP-Seq_H3396_Human	0.91267033
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90979332
95	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.89670312
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.88888835
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.88808255
98	TCF4_23295773_ChIP-Seq_U87_Human	0.88243280
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87891798
100	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87777791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.81782842
2	MP0002102_abnormal_ear_morphology	3.95821187
3	MP0005646_abnormal_pituitary_gland	3.29978874
4	MP0003950_abnormal_plasma_membrane	3.19388597
5	MP0008004_abnormal_stomach_pH	3.01224870
6	MP0003315_abnormal_perineum_morphology	2.96041447
7	MP0005499_abnormal_olfactory_system	2.59641475
8	MP0005394_taste/olfaction_phenotype	2.59641475
9	MP0008789_abnormal_olfactory_epithelium	2.50153762
10	MP0001968_abnormal_touch/_nociception	2.44455377
11	MP0006072_abnormal_retinal_apoptosis	2.34739896
12	MP0010030_abnormal_orbit_morphology	2.13495489
13	MP0002160_abnormal_reproductive_system	2.05028914
14	MP0005551_abnormal_eye_electrophysiolog	2.02212283
15	MP0002736_abnormal_nociception_after	2.00627567
16	MP0001984_abnormal_olfaction	2.00616491
17	MP0001929_abnormal_gametogenesis	1.94817478
18	MP0003698_abnormal_male_reproductive	1.84527339
19	MP0002653_abnormal_ependyma_morphology	1.80158996
20	MP0005253_abnormal_eye_physiology	1.79052287
21	MP0010368_abnormal_lymphatic_system	1.77525212
22	MP0008877_abnormal_DNA_methylation	1.76866148
23	MP0003718_maternal_effect	1.74846571
24	MP0008875_abnormal_xenobiotic_pharmacok	1.73173337
25	MP0009697_abnormal_copulation	1.73110593
26	MP0005248_abnormal_Harderian_gland	1.68970986
27	MP0000631_abnormal_neuroendocrine_gland	1.63464685
28	MP0003880_abnormal_central_pattern	1.62820794
29	MP0002837_dystrophic_cardiac_calcinosis	1.60090080
30	MP0001905_abnormal_dopamine_level	1.51634883
31	MP0001661_extended_life_span	1.48116929
32	MP0000049_abnormal_middle_ear	1.48086127
33	MP0008995_early_reproductive_senescence	1.47207977
34	MP0001764_abnormal_homeostasis	1.42166541
35	MP0006276_abnormal_autonomic_nervous	1.38247026
36	MP0001188_hyperpigmentation	1.36728629
37	MP0002234_abnormal_pharynx_morphology	1.34559857
38	MP0000750_abnormal_muscle_regeneration	1.34188685
39	MP0004885_abnormal_endolymph	1.28969025
40	MP0002735_abnormal_chemical_nociception	1.27733003
41	MP0008872_abnormal_physiological_respon	1.23218327
42	MP0005075_abnormal_melanosome_morpholog	1.20635966
43	MP0005360_urolithiasis	1.20377782
44	MP0002210_abnormal_sex_determination	1.19836403
45	MP0002272_abnormal_nervous_system	1.18858449
46	MP0009745_abnormal_behavioral_response	1.18852944
47	MP0001986_abnormal_taste_sensitivity	1.14872452
48	MP0003567_abnormal_fetal_cardiomyocyte	1.12811081
49	MP0000653_abnormal_sex_gland	1.12575585
50	MP0000026_abnormal_inner_ear	1.11966423
51	MP0004147_increased_porphyrin_level	1.11612634
52	MP0001501_abnormal_sleep_pattern	1.11464826
53	MP0005187_abnormal_penis_morphology	1.11263028
54	MP0002295_abnormal_pulmonary_circulatio	1.09186187
55	MP0006036_abnormal_mitochondrial_physio	1.09164595
56	MP0008058_abnormal_DNA_repair	1.08808328
57	MP0005389_reproductive_system_phenotype	1.08793638
58	MP0009046_muscle_twitch	1.07970201
59	MP0010386_abnormal_urinary_bladder	1.07275599
60	MP0003136_yellow_coat_color	1.06025018
61	MP0002127_abnormal_cardiovascular_syste	1.05466811
62	MP0001145_abnormal_male_reproductive	1.05354631
63	MP0001664_abnormal_digestion	1.04951338
64	MP0002138_abnormal_hepatobiliary_system	1.01360819
65	MP0003195_calcinosis	0.99422479
66	MP0002938_white_spotting	0.97889858
67	MP0005174_abnormal_tail_pigmentation	0.97714972
68	MP0003011_delayed_dark_adaptation	0.97559119
69	MP0001485_abnormal_pinna_reflex	0.96166560
70	MP0002638_abnormal_pupillary_reflex	0.95743811
71	MP0001963_abnormal_hearing_physiology	0.94584899
72	MP0002161_abnormal_fertility/fecundity	0.92905662
73	MP0000749_muscle_degeneration	0.90860616
74	MP0001486_abnormal_startle_reflex	0.90503142
75	MP0004145_abnormal_muscle_electrophysio	0.89165530
76	MP0002751_abnormal_autonomic_nervous	0.87590399
77	MP0001529_abnormal_vocalization	0.86903001
78	MP0006292_abnormal_olfactory_placode	0.86292307
79	MP0005391_vision/eye_phenotype	0.86287484
80	MP0005195_abnormal_posterior_eye	0.85610058
81	MP0002233_abnormal_nose_morphology	0.85255991
82	MP0000566_synostosis	0.84243157
83	MP0002752_abnormal_somatic_nervous	0.83991562
84	MP0005647_abnormal_sex_gland	0.83278469
85	MP0002733_abnormal_thermal_nociception	0.80885498
86	MP0003936_abnormal_reproductive_system	0.80199470
87	MP0005084_abnormal_gallbladder_morpholo	0.79494490
88	MP0002064_seizures	0.78010976
89	MP0005379_endocrine/exocrine_gland_phen	0.76039603
90	MP0003252_abnormal_bile_duct	0.76019002
91	MP0002572_abnormal_emotion/affect_behav	0.75217126
92	MP0003938_abnormal_ear_development	0.75034703
93	MP0001970_abnormal_pain_threshold	0.74656243
94	MP0003806_abnormal_nucleotide_metabolis	0.73497319
95	MP0004484_altered_response_of	0.72810223
96	MP0001119_abnormal_female_reproductive	0.72577783
97	MP0002067_abnormal_sensory_capabilities	0.70862707
98	MP0004142_abnormal_muscle_tone	0.68912126
99	MP0004084_abnormal_cardiac_muscle	0.68309937
100	MP0000230_abnormal_systemic_arterial	0.68175779

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.63605913
2	Pancreatic fibrosis (HP:0100732)	4.39131174
3	Pancreatic cysts (HP:0001737)	3.92047991
4	3-Methylglutaconic aciduria (HP:0003535)	3.75304896
5	Aplasia/hypoplasia of the uterus (HP:0008684)	3.62174995
6	Duplicated collecting system (HP:0000081)	3.48196469
7	Large for gestational age (HP:0001520)	3.42704457
8	Abnormality of the renal collecting system (HP:0004742)	3.35659085
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.21150858
10	Molar tooth sign on MRI (HP:0002419)	3.16263938
11	Abnormality of midbrain morphology (HP:0002418)	3.16263938
12	Male pseudohermaphroditism (HP:0000037)	3.11337595
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.10588383
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.10588383
15	Cystic liver disease (HP:0006706)	2.95448723
16	Sex reversal (HP:0012245)	2.94623776
17	Abnormal sex determination (HP:0012244)	2.94623776
18	Congenital stationary night blindness (HP:0007642)	2.91893183
19	Hepatocellular necrosis (HP:0001404)	2.90815578
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.88386430
21	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.86400456
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.83858743
23	Hypoplasia of the uterus (HP:0000013)	2.79280598
24	Cerebral hypomyelination (HP:0006808)	2.76939888
25	Absent/shortened dynein arms (HP:0200106)	2.70537711
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.70537711
27	Reduced antithrombin III activity (HP:0001976)	2.66816149
28	Nephronophthisis (HP:0000090)	2.66429327
29	Atonic seizures (HP:0010819)	2.59618031
30	Hepatic necrosis (HP:0002605)	2.59221257
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.57361083
32	Abnormality of alanine metabolism (HP:0010916)	2.57361083
33	Hyperalaninemia (HP:0003348)	2.57361083
34	Inability to walk (HP:0002540)	2.57207550
35	Chronic hepatic failure (HP:0100626)	2.55426642
36	Dyschromatopsia (HP:0007641)	2.55103743
37	Retinal dysplasia (HP:0007973)	2.52259235
38	Abnormal respiratory motile cilium physiology (HP:0012261)	2.49041968
39	Attenuation of retinal blood vessels (HP:0007843)	2.48811312
40	Abnormal ciliary motility (HP:0012262)	2.48433397
41	Abolished electroretinogram (ERG) (HP:0000550)	2.44537144
42	Anencephaly (HP:0002323)	2.41634017
43	Type II lissencephaly (HP:0007260)	2.40487725
44	Decreased central vision (HP:0007663)	2.39502703
45	Sclerocornea (HP:0000647)	2.38932736
46	B lymphocytopenia (HP:0010976)	2.38193793
47	Abnormality of B cell number (HP:0010975)	2.35601593
48	Severe visual impairment (HP:0001141)	2.34641963
49	Adactyly (HP:0009776)	2.33999447
50	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.33503301
51	Mitochondrial inheritance (HP:0001427)	2.31914244
52	Lipid accumulation in hepatocytes (HP:0006561)	2.29968510
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.29251247
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.29251247
55	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.28457665
56	Abnormal protein N-linked glycosylation (HP:0012347)	2.28457665
57	Abnormal protein glycosylation (HP:0012346)	2.28457665
58	Abnormal glycosylation (HP:0012345)	2.28457665
59	Unsteady gait (HP:0002317)	2.25697792
60	Cerebellar dysplasia (HP:0007033)	2.25219661
61	Scotoma (HP:0000575)	2.24896695
62	Abnormality of the pons (HP:0007361)	2.24402963
63	Protruding tongue (HP:0010808)	2.21256361
64	Abnormality of the renal medulla (HP:0100957)	2.19325449
65	Gonadal dysgenesis (HP:0000133)	2.18237253
66	Renal cortical cysts (HP:0000803)	2.15976830
67	Increased CSF lactate (HP:0002490)	2.15780699
68	Congenital hepatic fibrosis (HP:0002612)	2.14940195
69	Occipital encephalocele (HP:0002085)	2.14781387
70	Bile duct proliferation (HP:0001408)	2.14356184
71	Abnormal biliary tract physiology (HP:0012439)	2.14356184
72	Postnatal microcephaly (HP:0005484)	2.11329553
73	Optic nerve hypoplasia (HP:0000609)	2.10268281
74	Abnormality of macular pigmentation (HP:0008002)	2.10092127
75	Furrowed tongue (HP:0000221)	2.07938921
76	Central scotoma (HP:0000603)	2.05383804
77	Exercise-induced muscle cramps (HP:0003710)	2.02738376
78	Type 2 muscle fiber atrophy (HP:0003554)	1.95551902
79	Abnormality of the renal cortex (HP:0011035)	1.95285245
80	Absent speech (HP:0001344)	1.94464351
81	Increased serum lactate (HP:0002151)	1.94262517
82	Hyperglycinuria (HP:0003108)	1.92547342
83	Widely spaced teeth (HP:0000687)	1.90862782
84	Gaze-evoked nystagmus (HP:0000640)	1.89253325
85	Exercise-induced myalgia (HP:0003738)	1.89237793
86	Hyperglycinemia (HP:0002154)	1.88583906
87	Postaxial foot polydactyly (HP:0001830)	1.88180846
88	Medial flaring of the eyebrow (HP:0010747)	1.87518075
89	Severe muscular hypotonia (HP:0006829)	1.86453741
90	Abnormality of the columella (HP:0009929)	1.83770828
91	Pendular nystagmus (HP:0012043)	1.83515814
92	Aplastic anemia (HP:0001915)	1.81216148
93	Progressive microcephaly (HP:0000253)	1.80757851
94	CNS demyelination (HP:0007305)	1.80221913
95	Congenital primary aphakia (HP:0007707)	1.76264618
96	Optic disc pallor (HP:0000543)	1.74957150
97	Febrile seizures (HP:0002373)	1.74064126
98	Gait imbalance (HP:0002141)	1.71592141
99	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.70706643
100	Pachygyria (HP:0001302)	1.70513134

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.84922855
2	ZAK	3.45656006
3	MARK3	3.29751864
4	TLK1	3.28033726
5	BCKDK	2.90698810
6	ADRBK2	2.39704707
7	AKT3	2.38176126
8	MAP4K2	2.04312365
9	GRK1	2.00624787
10	MAP2K7	2.00590036
11	LATS1	1.89709359
12	VRK1	1.77023444
13	CSNK1G1	1.74525015
14	OBSCN	1.71861509
15	BMPR1B	1.65865780
16	CSNK1G3	1.64717002
17	FRK	1.62722117
18	INSRR	1.61632023
19	CSNK1A1L	1.55184446
20	CDK19	1.40864090
21	RPS6KA5	1.40283097
22	MYLK	1.37522453
23	CSNK1G2	1.25576358
24	NUAK1	1.23800448
25	CCNB1	1.20841292
26	TRIM28	1.19289051
27	PRKCQ	1.18282425
28	CASK	1.16837944
29	VRK2	1.11187753
30	TAF1	1.08983865
31	SGK494	1.05432750
32	SGK223	1.05432750
33	SGK2	0.99469631
34	MAP3K9	0.97160524
35	MAP3K4	0.95847298
36	PTK2B	0.95523639
37	EIF2AK3	0.94159510
38	ERBB3	0.93788140
39	BCR	0.93636641
40	ILK	0.92536734
41	KSR1	0.92497853
42	RPS6KA4	0.89507295
43	IRAK4	0.86089332
44	NEK2	0.85493248
45	PIK3CG	0.79050871
46	WNK3	0.77827031
47	BRAF	0.75828501
48	STK38L	0.75475771
49	FLT3	0.73154368
50	STK39	0.73074571
51	PAK3	0.72829205
52	ARAF	0.71644669
53	STK38	0.68539137
54	DYRK2	0.67571362
55	MAPK13	0.66337318
56	TIE1	0.64507449
57	DAPK1	0.63718300
58	PRKCI	0.62765797
59	TGFBR1	0.62496148
60	KIT	0.60870598
61	CDK8	0.59772140
62	CDK3	0.55817791
63	NTRK2	0.55478216
64	CSNK1A1	0.53716496
65	WNK4	0.53443219
66	OXSR1	0.52163214
67	ADRBK1	0.50611468
68	DAPK2	0.50429827
69	PIK3CA	0.49237193
70	PRKCE	0.48340397
71	NLK	0.47838388
72	PRKD2	0.46364275
73	MAPKAPK3	0.44047332
74	TNK2	0.41334354
75	PHKG2	0.37811238
76	PHKG1	0.37811238
77	SYK	0.37093170
78	PLK2	0.37092885
79	MKNK1	0.36592495
80	CAMK2A	0.36038859
81	PAK1	0.35415651
82	MAP3K5	0.35046010
83	TXK	0.34939224
84	PRKG1	0.34869168
85	MAP3K1	0.30758636
86	DYRK3	0.30694455
87	MAP2K4	0.30622586
88	MAP2K6	0.30440965
89	CDC7	0.28817117
90	SRPK1	0.28680570
91	TAOK3	0.26849614
92	PRKCG	0.26766612
93	RAF1	0.26174616
94	SGK3	0.26160738
95	CAMK2B	0.25602199
96	MAPK15	0.25546985
97	MINK1	0.25454998
98	PAK6	0.25452103
99	MUSK	0.24234416
100	CSNK1D	0.23474470

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.44307650
2	Phototransduction_Homo sapiens_hsa04744	3.00542315
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.91981431
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.82847834
5	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.45844831
6	Butanoate metabolism_Homo sapiens_hsa00650	2.44989863
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.39588263
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37366463
9	Parkinsons disease_Homo sapiens_hsa05012	2.19873013
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.18858567
11	Olfactory transduction_Homo sapiens_hsa04740	2.18530943
12	Basal transcription factors_Homo sapiens_hsa03022	2.08145867
13	Propanoate metabolism_Homo sapiens_hsa00640	2.03155763
14	Regulation of autophagy_Homo sapiens_hsa04140	1.96259365
15	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.82157481
16	Proteasome_Homo sapiens_hsa03050	1.79072856
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74224082
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.71736122
19	Peroxisome_Homo sapiens_hsa04146	1.59483585
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.58329408
21	Ribosome_Homo sapiens_hsa03010	1.57474522
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52177278
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.50289581
24	RNA polymerase_Homo sapiens_hsa03020	1.44636740
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41788829
26	Fatty acid elongation_Homo sapiens_hsa00062	1.41128428
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.38632985
28	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.36757921
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.34931547
30	Base excision repair_Homo sapiens_hsa03410	1.34005881
31	Gap junction_Homo sapiens_hsa04540	1.33462009
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30298711
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28031530
34	Caffeine metabolism_Homo sapiens_hsa00232	1.27693616
35	Alzheimers disease_Homo sapiens_hsa05010	1.23603905
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.23540299
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23388602
38	Purine metabolism_Homo sapiens_hsa00230	1.22080610
39	Huntingtons disease_Homo sapiens_hsa05016	1.21284002
40	Nicotine addiction_Homo sapiens_hsa05033	1.19545211
41	Taste transduction_Homo sapiens_hsa04742	1.16267530
42	Homologous recombination_Homo sapiens_hsa03440	1.15513098
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14857533
44	RNA degradation_Homo sapiens_hsa03018	1.13135329
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10231159
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.07527524
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01152710
48	Protein export_Homo sapiens_hsa03060	1.00900017
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96821879
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.96721112
51	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94234873
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91266111
53	Glutathione metabolism_Homo sapiens_hsa00480	0.86622250
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.86183310
55	Alcoholism_Homo sapiens_hsa05034	0.84859741
56	Metabolic pathways_Homo sapiens_hsa01100	0.82146795
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81594178
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80183183
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80098930
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76958341
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76035704
62	Retinol metabolism_Homo sapiens_hsa00830	0.75183674
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.74776063
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74480045
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72861504
66	Oocyte meiosis_Homo sapiens_hsa04114	0.67210741
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65486018
68	Circadian rhythm_Homo sapiens_hsa04710	0.65139304
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63068128
70	One carbon pool by folate_Homo sapiens_hsa00670	0.61840193
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61687419
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.61506433
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60616916
74	Mineral absorption_Homo sapiens_hsa04978	0.57270674
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56876347
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.55243828
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55082556
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54093226
79	Phagosome_Homo sapiens_hsa04145	0.53649524
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52101494
81	Circadian entrainment_Homo sapiens_hsa04713	0.52044270
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51302804
83	Fatty acid degradation_Homo sapiens_hsa00071	0.50433092
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47892487
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.46632338
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46160551
87	RNA transport_Homo sapiens_hsa03013	0.44604898
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44008814
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.43439280
90	GABAergic synapse_Homo sapiens_hsa04727	0.41226398
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.40976962
92	Arginine biosynthesis_Homo sapiens_hsa00220	0.40731388
93	Apoptosis_Homo sapiens_hsa04210	0.40614556
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37211337
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32767799
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32663731
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32488045
98	Spliceosome_Homo sapiens_hsa03040	0.31046337
99	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.30367453
100	Salivary secretion_Homo sapiens_hsa04970	0.28500377

CCDC192

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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