CCDC22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.57382679
2DNA strand elongation (GO:0022616)5.24244552
3DNA unwinding involved in DNA replication (GO:0006268)5.24068419
4telomere maintenance via semi-conservative replication (GO:0032201)5.21877814
5positive regulation of gamma-delta T cell activation (GO:0046645)5.04343045
6DNA replication initiation (GO:0006270)4.77958862
7ribosomal small subunit assembly (GO:0000028)4.68817986
8formation of translation preinitiation complex (GO:0001731)4.64193122
9DNA deamination (GO:0045006)4.48324689
10neutrophil activation involved in immune response (GO:0002283)4.47475806
11telomere maintenance via recombination (GO:0000722)4.37422420
12nucleobase biosynthetic process (GO:0046112)4.27310420
13IMP biosynthetic process (GO:0006188)4.26997910
14response to peptidoglycan (GO:0032494)4.23383725
15positive regulation of B cell differentiation (GO:0045579)4.21486997
16antigen processing and presentation of endogenous antigen (GO:0019883)4.19496772
17negative regulation of erythrocyte differentiation (GO:0045647)4.10567554
18maturation of SSU-rRNA (GO:0030490)3.99139800
19mitotic recombination (GO:0006312)3.98968831
20negative regulation of cell killing (GO:0031342)3.93487418
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.93487418
22detection of bacterium (GO:0016045)3.92906630
23IMP metabolic process (GO:0046040)3.91483818
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90805670
25regulation of translational fidelity (GO:0006450)3.89495035
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.85834146
27protein localization to kinetochore (GO:0034501)3.81116564
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.80718872
29detection of other organism (GO:0098543)3.80411373
30purine nucleobase biosynthetic process (GO:0009113)3.78396769
31telomere maintenance via telomere lengthening (GO:0010833)3.73507190
32viral transcription (GO:0019083)3.72704698
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70020729
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.70020729
35modulation by symbiont of host immune response (GO:0052553)3.70020729
36positive regulation by symbiont of host defense response (GO:0052509)3.70020729
37modulation by symbiont of host defense response (GO:0052031)3.70020729
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70020729
39immunoglobulin mediated immune response (GO:0016064)3.65392984
40folic acid-containing compound biosynthetic process (GO:0009396)3.65099267
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63989939
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.63543093
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59663495
44translational termination (GO:0006415)3.59460846
45purine nucleotide salvage (GO:0032261)3.59433535
46translational elongation (GO:0006414)3.57171728
47NIK/NF-kappaB signaling (GO:0038061)3.55680155
48positive thymic T cell selection (GO:0045059)3.53468680
49pseudouridine synthesis (GO:0001522)3.51432853
50regulation of gamma-delta T cell activation (GO:0046643)3.50366253
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49680466
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41955993
53leukocyte aggregation (GO:0070486)3.38118752
54pentose-phosphate shunt (GO:0006098)3.36054678
55regulation of gamma-delta T cell differentiation (GO:0045586)3.27485184
56mitotic G1 DNA damage checkpoint (GO:0031571)3.27435474
57translational initiation (GO:0006413)3.27250050
58regulation of B cell differentiation (GO:0045577)3.26866802
59mucosal-associated lymphoid tissue development (GO:0048537)3.26516177
60Peyers patch development (GO:0048541)3.26516177
61mitotic nuclear envelope disassembly (GO:0007077)3.24234277
62regulation of B cell receptor signaling pathway (GO:0050855)3.23302365
63regulation of protein heterodimerization activity (GO:0043497)3.21784727
64DNA duplex unwinding (GO:0032508)3.21570136
65regulation of superoxide anion generation (GO:0032928)3.21365118
66DNA geometric change (GO:0032392)3.20680457
67negative regulation of interleukin-12 production (GO:0032695)3.16333185
68viral mRNA export from host cell nucleus (GO:0046784)3.15456447
69negative regulation of RNA splicing (GO:0033119)3.14820336
70Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14510244
71negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.09975251
72DNA replication-dependent nucleosome organization (GO:0034723)3.07710341
73DNA replication-dependent nucleosome assembly (GO:0006335)3.07710341
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05541649
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05329233
76macrophage activation involved in immune response (GO:0002281)3.04796755
77pinocytosis (GO:0006907)3.01970859
78ribosomal small subunit biogenesis (GO:0042274)3.01372978
79thymic T cell selection (GO:0045061)3.01197202
80base-excision repair (GO:0006284)3.00110110
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99271434
82regulation of mast cell degranulation (GO:0043304)2.98692188
83regulation of antigen processing and presentation (GO:0002577)2.98123024
84viral life cycle (GO:0019058)2.97947158
85negative thymic T cell selection (GO:0045060)2.97598231
86nuclear envelope disassembly (GO:0051081)2.97555225
87membrane disassembly (GO:0030397)2.97555225
88spliceosomal snRNP assembly (GO:0000387)2.97121770
89nucleotide salvage (GO:0043173)2.96380697
90response to muramyl dipeptide (GO:0032495)2.96367432
91mitochondrial RNA metabolic process (GO:0000959)2.94852166
92ribosome biogenesis (GO:0042254)2.93196235
93B cell receptor signaling pathway (GO:0050853)2.91487200
94mitotic sister chromatid segregation (GO:0000070)2.91269203
95cotranslational protein targeting to membrane (GO:0006613)2.89470727
96NADPH regeneration (GO:0006740)2.89093349
97DNA replication checkpoint (GO:0000076)2.89019121
98protein targeting to ER (GO:0045047)2.88212285
99negative regulation of necroptotic process (GO:0060546)2.87052646
100G1/S transition of mitotic cell cycle (GO:0000082)2.85871558
101cell cycle G1/S phase transition (GO:0044843)2.85871558
102peptidyl-arginine omega-N-methylation (GO:0035247)2.84921593
103neutrophil activation (GO:0042119)2.84284764
104tRNA aminoacylation for protein translation (GO:0006418)2.83953764
105cellular protein complex disassembly (GO:0043624)2.83528868
106ncRNA 3-end processing (GO:0043628)2.83447483
107protein localization to chromosome, centromeric region (GO:0071459)2.82483952
108pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.81892042
109response to host immune response (GO:0052572)2.81262926
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81262926
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81120104
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80928791
113rRNA processing (GO:0006364)2.80558095
114T cell selection (GO:0045058)2.80367504
115tRNA aminoacylation (GO:0043039)2.80364134
116amino acid activation (GO:0043038)2.80364134
117negative regulation of mRNA processing (GO:0050686)2.80142197
118L-serine metabolic process (GO:0006563)2.79849575
119spliceosomal tri-snRNP complex assembly (GO:0000244)2.79489912
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.79474445
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79474445
122regulation of myeloid leukocyte mediated immunity (GO:0002886)2.78230841
123purine-containing compound salvage (GO:0043101)2.77960543
124ribonucleoprotein complex biogenesis (GO:0022613)2.77837827
125negative T cell selection (GO:0043383)2.77587689
126respiratory burst (GO:0045730)2.77205848
127detection of external biotic stimulus (GO:0098581)2.76485974
128regulation of leukocyte degranulation (GO:0043300)2.76227040
129phosphatidylglycerol biosynthetic process (GO:0006655)2.75707384
130folic acid metabolic process (GO:0046655)2.75120307
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75006327
132mRNA splicing, via spliceosome (GO:0000398)2.75006327
133myeloid cell activation involved in immune response (GO:0002275)2.74765976
134type I interferon signaling pathway (GO:0060337)2.74198000
135cellular response to type I interferon (GO:0071357)2.74198000
136B cell mediated immunity (GO:0019724)2.72843762
137telomere organization (GO:0032200)2.72798118
138histone H2A acetylation (GO:0043968)2.72198987
139protein localization to endoplasmic reticulum (GO:0070972)2.71654824
140RNA splicing, via transesterification reactions (GO:0000375)2.71167838
141response to type I interferon (GO:0034340)2.70365138
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70118111
143establishment of protein localization to endoplasmic reticulum (GO:0072599)2.69723153
144granulocyte activation (GO:0036230)2.69618190
145mature B cell differentiation involved in immune response (GO:0002313)2.69257359
146telomere maintenance (GO:0000723)2.69031915
147translesion synthesis (GO:0019985)2.68830220
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68758228
149rRNA metabolic process (GO:0016072)2.68283811
150pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.68161433
151positive regulation of antigen processing and presentation (GO:0002579)2.68114555
152negative regulation of histone acetylation (GO:0035067)2.68042279
153protein complex disassembly (GO:0043241)2.66442072
154response to host (GO:0075136)2.65901118
155response to host defenses (GO:0052200)2.65901118
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65901118
157negative regulation of ligase activity (GO:0051352)2.63185558
158negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63185558
159mitotic chromosome condensation (GO:0007076)2.62690187
160negative regulation of innate immune response (GO:0045824)2.62411099
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62286733
162mitotic G1/S transition checkpoint (GO:0044819)2.62132537
163regulation of necroptotic process (GO:0060544)2.61524744
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61128628
165regulation of necrotic cell death (GO:0010939)2.60133894
166positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59590514
1673-UTR-mediated mRNA stabilization (GO:0070935)2.59292527
168histone arginine methylation (GO:0034969)2.59279476
169G1 DNA damage checkpoint (GO:0044783)2.58820057
170L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57955047
171establishment of integrated proviral latency (GO:0075713)2.57216016
172detection of biotic stimulus (GO:0009595)2.56815245
173postreplication repair (GO:0006301)2.56268475
174regulation of mast cell activation involved in immune response (GO:0033006)2.56129759
175nucleobase-containing small molecule interconversion (GO:0015949)2.55080718
176natural killer cell differentiation (GO:0001779)2.54950017
177sulfur amino acid catabolic process (GO:0000098)2.54372553
178mannose metabolic process (GO:0006013)2.53455303
179negative regulation of leukocyte mediated immunity (GO:0002704)2.52280402
180modulation by virus of host process (GO:0019054)2.52150024
181regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.52051294
182regulation of T cell tolerance induction (GO:0002664)2.51483289
183glycosphingolipid catabolic process (GO:0046479)2.51183448
184T cell migration (GO:0072678)2.50592526
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50526792
186negative regulation of B cell apoptotic process (GO:0002903)2.50438077
187negative regulation of phagocytosis (GO:0050765)2.48310828
188cellular response to interleukin-4 (GO:0071353)2.46635125
189regulation of interferon-beta biosynthetic process (GO:0045357)2.45856005
190amino sugar catabolic process (GO:0046348)2.45637654
191positive T cell selection (GO:0043368)2.45615924
192regulation of interleukin-2 biosynthetic process (GO:0045076)2.43859899
193interferon-gamma-mediated signaling pathway (GO:0060333)2.43000880
194negative regulation of lymphocyte mediated immunity (GO:0002707)2.42509328
195regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42458394
196response to thyroid hormone (GO:0097066)2.42252070
197myeloid dendritic cell activation (GO:0001773)2.40173265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31082944
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.30582298
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.58481207
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.75824204
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74193563
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67519966
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64442956
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54885354
9MYC_22102868_ChIP-Seq_BL_Human2.52219543
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48271165
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43582099
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.37210833
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36625493
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.34098802
15VDR_21846776_ChIP-Seq_THP-1_Human2.33762065
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.33359374
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32429735
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15064408
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14062339
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10059199
21XRN2_22483619_ChIP-Seq_HELA_Human2.09689594
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02270929
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.00087481
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98574968
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98481760
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.96899329
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96744366
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95243326
29CIITA_25753668_ChIP-Seq_RAJI_Human1.91240958
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81506822
31VDR_23849224_ChIP-Seq_CD4+_Human1.79008734
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78184096
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77329682
34GABP_19822575_ChIP-Seq_HepG2_Human1.71254899
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71203513
36MAF_26560356_Chip-Seq_TH2_Human1.70461239
37DCP1A_22483619_ChIP-Seq_HELA_Human1.69509225
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.68675345
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66568046
40FOXP3_21729870_ChIP-Seq_TREG_Human1.64340694
41SCL_19346495_ChIP-Seq_HPC-7_Human1.61600940
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61090427
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61080540
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60836785
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59483473
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59400452
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.57467262
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56335481
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56185648
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55945124
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54249798
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53795293
53TTF2_22483619_ChIP-Seq_HELA_Human1.52135644
54KDM2B_26808549_Chip-Seq_DND41_Human1.51501364
55RACK7_27058665_Chip-Seq_MCF-7_Human1.50992327
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48199155
57P68_20966046_ChIP-Seq_HELA_Human1.47658003
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46933353
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45524833
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45389479
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45045541
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44900669
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43384428
64KDM5A_27292631_Chip-Seq_BREAST_Human1.43268127
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.42545810
66TFEB_21752829_ChIP-Seq_HELA_Human1.42048879
67BCOR_27268052_Chip-Seq_Bcells_Human1.39286302
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39168072
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38616182
70* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38392483
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38045398
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37786552
73NCOR1_26117541_ChIP-Seq_K562_Human1.37321946
74SPI1_23127762_ChIP-Seq_K562_Human1.36991230
75* SPI1_23547873_ChIP-Seq_NB4_Human1.36975101
76BCL6_27268052_Chip-Seq_Bcells_Human1.36621175
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35874288
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.35383166
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30447663
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.30062261
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29857690
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29549444
83MYB_26560356_Chip-Seq_TH2_Human1.29053837
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.25762781
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24558438
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24160706
87ZNF263_19887448_ChIP-Seq_K562_Human1.24077975
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23198822
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22704335
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22447691
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21919422
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.20411947
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20260864
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.20162672
95AR_21909140_ChIP-Seq_LNCAP_Human1.20141909
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19307385
97MYB_26560356_Chip-Seq_TH1_Human1.18967577
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18641095
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.18139537
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17655894
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15781757
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15291569
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15014574
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13692205
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.12156434
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11546301
107UTX_26944678_Chip-Seq_JUKART_Human1.11417101
108MAF_26560356_Chip-Seq_TH1_Human1.11117064
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.10973694
110VDR_24763502_ChIP-Seq_THP-1_Human1.10858116
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10766282
112* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09611374
113IRF8_21731497_ChIP-ChIP_J774_Mouse1.09524841
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08406196
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08099337
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07064247
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06999230
118* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06903748
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05834320
120* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05737286
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05703692
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04212901
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04209047
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03319989
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03288247
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03045953
127TCF7_22412390_ChIP-Seq_EML_Mouse1.03014079
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02686273
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02548060
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01706498
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01596915
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01136761
133ETS1_21867929_ChIP-Seq_TH2_Mouse1.00965479
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.00751024
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98278335
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97982524
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97711166
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95696616
139LXR_22292898_ChIP-Seq_THP-1_Human0.95410383
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95239999
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94296234
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93260830
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.92894338
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92022918
145PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91040108
146ELK1_19687146_ChIP-ChIP_HELA_Human0.89562497
147ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88340657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.95272076
2MP0002396_abnormal_hematopoietic_system3.72027130
3MP0010094_abnormal_chromosome_stability3.66524896
4MP0003111_abnormal_nucleus_morphology3.43372735
5MP0004957_abnormal_blastocyst_morpholog3.40610707
6MP0003077_abnormal_cell_cycle3.22254291
7MP0003172_abnormal_lysosome_physiology2.97277102
8MP0008057_abnormal_DNA_replication2.85572241
9MP0005451_abnormal_body_composition2.69321716
10MP0005058_abnormal_lysosome_morphology2.69129812
11MP0008007_abnormal_cellular_replicative2.65224462
12MP0003724_increased_susceptibility_to2.65017307
13MP0008058_abnormal_DNA_repair2.33020668
14MP0008260_abnormal_autophagy2.31880280
15MP0005387_immune_system_phenotype2.26064163
16MP0001790_abnormal_immune_system2.26064163
17MP0010352_gastrointestinal_tract_polyps2.22105529
18MP0000490_abnormal_crypts_of2.19599892
19MP0002132_abnormal_respiratory_system2.12831467
20MP0003303_peritoneal_inflammation2.12648427
21MP0004808_abnormal_hematopoietic_stem2.11219654
22MP0003656_abnormal_erythrocyte_physiolo2.07290876
23MP0005397_hematopoietic_system_phenotyp2.02458575
24MP0001545_abnormal_hematopoietic_system2.02458575
25MP0003806_abnormal_nucleotide_metabolis1.99266705
26MP0003300_gastrointestinal_ulcer1.97313971
27MP0003436_decreased_susceptibility_to1.96098848
28MP0001730_embryonic_growth_arrest1.95494505
29MP0009333_abnormal_splenocyte_physiolog1.93014372
30MP0006082_CNS_inflammation1.88422703
31MP0000689_abnormal_spleen_morphology1.85603646
32MP0002398_abnormal_bone_marrow1.83227885
33MP0005464_abnormal_platelet_physiology1.82487773
34MP0008932_abnormal_embryonic_tissue1.80838274
35MP0000350_abnormal_cell_proliferation1.80109152
36MP0002722_abnormal_immune_system1.76659817
37MP0010307_abnormal_tumor_latency1.71618970
38MP0000465_gastrointestinal_hemorrhage1.65595617
39MP0001835_abnormal_antigen_presentation1.64733564
40MP0004947_skin_inflammation1.64028240
41MP0003123_paternal_imprinting1.63152799
42MP0001533_abnormal_skeleton_physiology1.59427036
43MP0002019_abnormal_tumor_incidence1.59411551
44MP0002429_abnormal_blood_cell1.53830426
45MP0000313_abnormal_cell_death1.53249870
46MP0000703_abnormal_thymus_morphology1.52725074
47MP0003221_abnormal_cardiomyocyte_apopto1.52146679
48MP0009278_abnormal_bone_marrow1.49389757
49MP0002080_prenatal_lethality1.43821203
50MP0003183_abnormal_peptide_metabolism1.43419644
51MP0001853_heart_inflammation1.42288700
52MP0005075_abnormal_melanosome_morpholog1.41901791
53MP0001800_abnormal_humoral_immune1.40505684
54MP0000716_abnormal_immune_system1.39793311
55MP0002452_abnormal_antigen_presenting1.38957937
56MP0002420_abnormal_adaptive_immunity1.37943626
57MP0000358_abnormal_cell_content/1.36696810
58MP0001819_abnormal_immune_cell1.36695656
59MP0001697_abnormal_embryo_size1.34992584
60MP0005360_urolithiasis1.34899556
61MP0003075_altered_response_to1.33983358
62MP0005174_abnormal_tail_pigmentation1.33013241
63MP0002419_abnormal_innate_immunity1.32632253
64MP0000685_abnormal_immune_system1.30526972
65MP0002877_abnormal_melanocyte_morpholog1.28760826
66MP0006036_abnormal_mitochondrial_physio1.26236011
67MP0005025_abnormal_response_to1.22852263
68MP0002723_abnormal_immune_serum1.22013515
69MP0004185_abnormal_adipocyte_glucose1.19092361
70MP0003191_abnormal_cellular_cholesterol1.18598060
71MP0003984_embryonic_growth_retardation1.18360361
72MP0005380_embryogenesis_phenotype1.18049946
73MP0001672_abnormal_embryogenesis/_devel1.18049946
74MP0002088_abnormal_embryonic_growth/wei1.16170995
75MP0004147_increased_porphyrin_level1.15146425
76MP0009840_abnormal_foam_cell1.15044125
77MP0003763_abnormal_thymus_physiology1.14637723
78MP0002405_respiratory_system_inflammati1.14626036
79MP0005670_abnormal_white_adipose1.11754891
80MP0000678_abnormal_parathyroid_gland1.10327060
81MP0004133_heterotaxia1.10280072
82MP0006035_abnormal_mitochondrial_morpho1.09172188
83MP0005000_abnormal_immune_tolerance1.08885816
84MP0002086_abnormal_extraembryonic_tissu1.08643479
85MP0003566_abnormal_cell_adhesion1.07102807
86MP0003186_abnormal_redox_activity1.06712037
87MP0003786_premature_aging1.03123979
88MP0005166_decreased_susceptibility_to1.02057217
89MP0003866_abnormal_defecation1.00550122
90MP0005384_cellular_phenotype1.00317720
91MP0001851_eye_inflammation0.98451071
92MP0000343_altered_response_to0.97515967
93MP0005076_abnormal_cell_differentiation0.96546958
94MP0001873_stomach_inflammation0.95763098
95MP0005621_abnormal_cell_physiology0.95666772
96MP0005266_abnormal_metabolism0.95515195
97MP0001849_ear_inflammation0.94645068
98MP0003705_abnormal_hypodermis_morpholog0.94627719
99MP0009764_decreased_sensitivity_to0.94218006
100MP0002269_muscular_atrophy0.93470411
101MP0000015_abnormal_ear_pigmentation0.92162113
102MP0008995_early_reproductive_senescence0.91657117
103MP0005310_abnormal_salivary_gland0.91272949
104MP0000604_amyloidosis0.90961870
105MP0000598_abnormal_liver_morphology0.90433744
106MP0004197_abnormal_fetal_growth/weight/0.90413375
107MP0000858_altered_metastatic_potential0.89379194
108MP0000371_diluted_coat_color0.89290824
109MP0002148_abnormal_hypersensitivity_rea0.87359561
110MP0002085_abnormal_embryonic_tissue0.87324179
111MP0005671_abnormal_response_to0.86875668
112MP0002084_abnormal_developmental_patter0.86476587
113MP0002998_abnormal_bone_remodeling0.86366422
114MP0008873_increased_physiological_sensi0.86064711
115MP0009785_altered_susceptibility_to0.85915365
116MP0002138_abnormal_hepatobiliary_system0.85637253
117MP0000681_abnormal_thyroid_gland0.85081859
118MP0002089_abnormal_postnatal_growth/wei0.83801076
119MP0004510_myositis0.82789683
120MP0003567_abnormal_fetal_cardiomyocyte0.81389329
121MP0005023_abnormal_wound_healing0.80105056
122MP0006054_spinal_hemorrhage0.79691139
123MP0008770_decreased_survivor_rate0.78052300
124MP0001845_abnormal_inflammatory_respons0.76787498
125MP0003828_pulmonary_edema0.76603994
126MP0002166_altered_tumor_susceptibility0.76343015
127MP0003121_genomic_imprinting0.76285815
128MP0010155_abnormal_intestine_physiology0.76175015
129MP0008469_abnormal_protein_level0.76015521
130MP0001915_intracranial_hemorrhage0.75650473
131MP0003453_abnormal_keratinocyte_physiol0.74072809
132MP0009763_increased_sensitivity_to0.73728119
133MP0001661_extended_life_span0.73336130
134MP0005390_skeleton_phenotype0.71815029
135MP0000747_muscle_weakness0.71197556
136MP0005584_abnormal_enzyme/coenzyme_acti0.71017156
137MP0005319_abnormal_enzyme/_coenzyme0.70536966
138MP0001764_abnormal_homeostasis0.68315786
139MP0001663_abnormal_digestive_system0.67825432
140MP0003795_abnormal_bone_structure0.67492169
141MP0005666_abnormal_adipose_tissue0.65939039
142MP0009931_abnormal_skin_appearance0.65802555
143MP0008874_decreased_physiological_sensi0.64319729
144MP0002277_abnormal_respiratory_mucosa0.64148429
145MP0003448_altered_tumor_morphology0.63764371

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.02252195
2Abnormality of macrophages (HP:0004311)3.98593748
3Reticulocytopenia (HP:0001896)3.75643558
4Agnosia (HP:0010524)3.73063449
5Thrombocytosis (HP:0001894)3.69889082
6Abnormal number of erythroid precursors (HP:0012131)3.66660996
7Chronic obstructive pulmonary disease (HP:0006510)3.62501135
8Obstructive lung disease (HP:0006536)3.62501135
9Abnormality of cells of the erythroid lineage (HP:0012130)3.60993742
10Spontaneous hematomas (HP:0007420)3.58432985
11Myositis (HP:0100614)3.39370442
12Birth length less than 3rd percentile (HP:0003561)3.39032086
13Hypertensive crisis (HP:0100735)3.24338999
14Abnormality of liposaccharide metabolism (HP:0010968)3.23679339
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.23679339
16Abnormality of glycolipid metabolism (HP:0010969)3.23679339
17Ependymoma (HP:0002888)3.06629184
18Meningitis (HP:0001287)3.03671112
19Fatigue (HP:0012378)2.93500352
20Urticaria (HP:0001025)2.91993367
21Elevated erythrocyte sedimentation rate (HP:0003565)2.88613848
22Recurrent skin infections (HP:0001581)2.88459423
23Loss of speech (HP:0002371)2.85956588
24Agammaglobulinemia (HP:0004432)2.82470428
25Recurrent fungal infections (HP:0002841)2.80788394
26Increased IgE level (HP:0003212)2.79602832
27Petechiae (HP:0000967)2.76183281
28IgM deficiency (HP:0002850)2.75742184
29Recurrent gram-negative bacterial infections (HP:0005420)2.73218376
30Multiple enchondromatosis (HP:0005701)2.64947596
31Colitis (HP:0002583)2.63919355
32Gastrointestinal inflammation (HP:0004386)2.63089347
33Pallor (HP:0000980)2.61528473
34Vacuolated lymphocytes (HP:0001922)2.61000278
35Granulocytopenia (HP:0001913)2.59622541
36Purpura (HP:0000979)2.59398834
37Cholecystitis (HP:0001082)2.58262377
38Abnormal gallbladder physiology (HP:0012438)2.58262377
39Anorexia (HP:0002039)2.56688779
40Polygenic inheritance (HP:0010982)2.56311842
41Increased cerebral lipofuscin (HP:0011813)2.56230034
42Basal cell carcinoma (HP:0002671)2.55019909
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.54984597
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.52179547
45Gastrointestinal infarctions (HP:0005244)2.50314029
46Recurrent abscess formation (HP:0002722)2.49477544
47Abnormality of reticulocytes (HP:0004312)2.47694646
48Inflammation of the large intestine (HP:0002037)2.47354339
49Pustule (HP:0200039)2.47328204
50Hypergammaglobulinemia (HP:0010702)2.47066680
51Cerebral hypomyelination (HP:0006808)2.46969300
52Increased IgM level (HP:0003496)2.45505297
53Hepatosplenomegaly (HP:0001433)2.44589082
54Medulloblastoma (HP:0002885)2.44568325
55Aplastic anemia (HP:0001915)2.43880606
56Epistaxis (HP:0000421)2.39735310
57Selective tooth agenesis (HP:0001592)2.38973074
58Oral leukoplakia (HP:0002745)2.37818771
59Degeneration of anterior horn cells (HP:0002398)2.37470392
60Abnormality of the anterior horn cell (HP:0006802)2.37470392
61Colon cancer (HP:0003003)2.35624185
62Macrocytic anemia (HP:0001972)2.35241356
63Spastic diplegia (HP:0001264)2.32624215
64Myopathic facies (HP:0002058)2.31440600
65Autoimmune hemolytic anemia (HP:0001890)2.30985652
66Poikiloderma (HP:0001029)2.30340242
67Stomatitis (HP:0010280)2.28224431
68Dysostosis multiplex (HP:0000943)2.28135755
69Myocardial infarction (HP:0001658)2.27903497
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25727748
71Orchitis (HP:0100796)2.25678712
72Gastrointestinal dysmotility (HP:0002579)2.25425488
73Panhypogammaglobulinemia (HP:0003139)2.25173430
74Rough bone trabeculation (HP:0100670)2.24703060
75Vasculitis (HP:0002633)2.23998105
76Microretrognathia (HP:0000308)2.23212148
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.21161591
78Personality changes (HP:0000751)2.20821261
79Cutaneous melanoma (HP:0012056)2.20723826
80Recurrent viral infections (HP:0004429)2.19895642
81Recurrent cutaneous fungal infections (HP:0011370)2.19286749
82Chronic mucocutaneous candidiasis (HP:0002728)2.19286749
83Encephalitis (HP:0002383)2.15788593
84Autoimmune thrombocytopenia (HP:0001973)2.15226106
85Slow saccadic eye movements (HP:0000514)2.12530591
86Abnormal platelet function (HP:0011869)2.11581128
87Impaired platelet aggregation (HP:0003540)2.11581128
88Abnormality of glycolysis (HP:0004366)2.11338605
89Increased serum pyruvate (HP:0003542)2.11338605
90Systemic lupus erythematosus (HP:0002725)2.10449675
91Poor head control (HP:0002421)2.09631022
92Urinary glycosaminoglycan excretion (HP:0003541)2.09386233
93Mucopolysacchariduria (HP:0008155)2.09386233
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08966824
95Bone marrow hypocellularity (HP:0005528)2.08550257
96Cellular immunodeficiency (HP:0005374)2.08053048
97Myelodysplasia (HP:0002863)2.07143886
98Arterial thrombosis (HP:0004420)2.04738710
99Megaloblastic anemia (HP:0001889)2.04496795
100Abnormality of pyrimidine metabolism (HP:0004353)2.04461968
101Pancytopenia (HP:0001876)2.04149819
102Chest pain (HP:0100749)2.04090800
103Squamous cell carcinoma (HP:0002860)2.03559657
104Recurrent bacterial skin infections (HP:0005406)2.02918555
105Esophageal varix (HP:0002040)2.01738733
106Sepsis (HP:0100806)2.01348621
107Pulmonary embolism (HP:0002204)2.01015074
108Esophageal neoplasm (HP:0100751)2.00723315
109Neoplasm of head and neck (HP:0012288)2.00723315
110Astrocytoma (HP:0009592)2.00338483
111Abnormality of the astrocytes (HP:0100707)2.00338483
112Amyloidosis (HP:0011034)2.00002870
113Seborrheic dermatitis (HP:0001051)1.99801088
114Prolonged bleeding time (HP:0003010)1.99712235
115Gastrointestinal stroma tumor (HP:0100723)1.98602730
116Increased density of long bones (HP:0006392)1.98326403
117Vertebral compression fractures (HP:0002953)1.97502516
118Ragged-red muscle fibers (HP:0003200)1.97092064
119Abnormality of the motor neurons (HP:0002450)1.96740558
120Abnormal neuron morphology (HP:0012757)1.96740558
121Abnormality of T cell physiology (HP:0011840)1.96637225
122Distal lower limb amyotrophy (HP:0008944)1.95607027
123Hypokinesia (HP:0002375)1.95333692
124Progressive neurologic deterioration (HP:0002344)1.94901110
125Proximal placement of thumb (HP:0009623)1.94492065
126Neurodegeneration (HP:0002180)1.94139175
127Acute lymphatic leukemia (HP:0006721)1.92604620
128Abnormality of the thoracic spine (HP:0100711)1.92119227
129Hemoptysis (HP:0002105)1.92016188
130Gingivitis (HP:0000230)1.91883356
131Lymphopenia (HP:0001888)1.91328240
132Optic neuritis (HP:0100653)1.91279862
133Retrobulbar optic neuritis (HP:0100654)1.91279862
134Ileus (HP:0002595)1.90543057
135Chronic otitis media (HP:0000389)1.90292087
136Adenoma sebaceum (HP:0009720)1.90273429
137Angiofibromas (HP:0010615)1.90273429
138Cellulitis (HP:0100658)1.89886217
139Increased serum lactate (HP:0002151)1.88469852
140Premature graying of hair (HP:0002216)1.88343355
141Breast hypoplasia (HP:0003187)1.88118216
142Verrucae (HP:0200043)1.88102805
143Papilloma (HP:0012740)1.88102805
144Reduced antithrombin III activity (HP:0001976)1.88057706
145Hypertriglyceridemia (HP:0002155)1.87940485
146Gingival bleeding (HP:0000225)1.87634222
147Thoracic kyphosis (HP:0002942)1.87512499
148Type I transferrin isoform profile (HP:0003642)1.86525003
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.84784426
150Mediastinal lymphadenopathy (HP:0100721)1.83963201
151Slender long bone (HP:0003100)1.83825379
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.81509470
153Deviation of the thumb (HP:0009603)1.80654160
154Increased serum ferritin (HP:0003281)1.80086383
155Spinal muscular atrophy (HP:0007269)1.79663714
156Prolonged neonatal jaundice (HP:0006579)1.79487362
157Upper motor neuron abnormality (HP:0002127)1.77626348
158Distal lower limb muscle weakness (HP:0009053)1.77427814
159Pulmonary infiltrates (HP:0002113)1.77137016
160Reticulocytosis (HP:0001923)1.75723383
161Abnormality of polysaccharide metabolism (HP:0011012)1.75042544
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75042544
163Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75042544
164Osteomyelitis (HP:0002754)1.74754745
165Abnormality of T cells (HP:0002843)1.74663658
166Diminished motivation (HP:0000745)1.73254162
167Skin ulcer (HP:0200042)1.73108848
168Emotional lability (HP:0000712)1.72966060
169Opisthotonus (HP:0002179)1.72575103
170Hyperacusis (HP:0010780)1.72196823
171Neoplasm of the pancreas (HP:0002894)1.72039799
172Atrophy/Degeneration involving motor neurons (HP:0007373)1.71242244
173Hypermelanotic macule (HP:0001034)1.69447694
174Joint stiffness (HP:0001387)1.69062479
175High pitched voice (HP:0001620)1.68854115
176Lymphoma (HP:0002665)1.67826258
177Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65821947
178Severe visual impairment (HP:0001141)1.65732197
179Postnatal microcephaly (HP:0005484)1.65415400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.27887145
2EEF2K3.16053271
3SMG13.01336885
4WEE12.77224462
5PRPF4B2.76802152
6RIPK42.70553559
7SCYL22.61070471
8NEK12.45596431
9MAP3K32.41534146
10CDC72.37894017
11IRAK32.29212252
12MAP4K12.23114583
13EIF2AK12.22982169
14TSSK62.12546688
15NME22.00077336
16PKN21.93737966
17NEK21.93104373
18JAK31.89485429
19MAP3K111.85154974
20KIT1.85061643
21TRIB31.82677361
22STK161.81304496
23GRK61.73249957
24BCKDK1.70570372
25TGFBR11.69397198
26DAPK11.68678584
27PAK41.67243186
28VRK11.59222119
29EIF2AK31.57365914
30ACVR1B1.48997529
31RPS6KB21.48947185
32TESK11.47486945
33ERN11.46835967
34SIK21.43390603
35TNK21.43046288
36CCNB11.41354879
37CDK71.41022430
38CSF1R1.40558857
39MAP3K101.37912222
40SIK11.37490296
41CDK81.36997319
42VRK21.28226463
43TESK21.28110489
44ICK1.27456787
45RPS6KA41.27201211
46PIM21.27143832
47FES1.27010993
48MAP3K141.26973651
49CSK1.24097064
50MAP2K31.23896752
51BLK1.22804343
52FGR1.22502593
53ATR1.21827843
54DYRK31.21265838
55CDK91.20045657
56IRAK21.17964287
57FLT31.17875647
58ZAP701.16465844
59PLK11.12812094
60MAP3K131.12127773
61MAP3K81.11720247
62BTK1.10994383
63IKBKE1.07737574
64MATK1.07725156
65TYK21.06892475
66PASK1.02856382
67ARAF0.98607818
68MAP3K120.98019315
69STK100.96850899
70IKBKB0.93654342
71STK40.91629822
72TTK0.91614094
73MAPKAPK30.91394499
74TAOK20.89111126
75PTK60.88917481
76MAP3K10.87638849
77CDK190.86650447
78SYK0.85711764
79CDK40.85710317
80PIM10.85080950
81PRKD20.84777677
82CAMKK20.84701568
83AURKB0.83921140
84TBK10.82895154
85YES10.81717903
86MAP3K60.80480381
87TTN0.79957805
88BRSK20.79400999
89RPS6KA60.76832852
90LRRK20.75972943
91RPS6KL10.75176362
92RPS6KC10.75176362
93BRSK10.72877293
94TAOK10.72038730
95JAK20.71804534
96CHEK10.71705048
97KDR0.69643613
98CHEK20.69430506
99ALK0.66153466
100CDK120.64331494
101TEC0.63674632
102TLK10.62505991
103EPHB10.62385127
104ITK0.62340762
105MAPKAPK20.59420501
106LYN0.58947315
107TGFBR20.58467605
108CAMK40.57958840
109SRPK10.57940888
110MAPK110.57734297
111CDK20.57671986
112AURKA0.57569118
113MAPK120.57497433
114PDPK10.55578886
115PAK10.54450563
116LMTK20.54264863
117MARK20.52206888
118DYRK1B0.51807386
119HIPK20.51520114
120CAMKK10.51375615
121RPS6KA20.51373123
122CSNK2A20.51156488
123LCK0.50815765
124SIK30.48511059
125PDK10.48498291
126KSR20.47689257
127PLK30.45839775
128TXK0.43856101
129MAP2K20.43567788
130IRAK40.42279397
131DAPK30.39951641
132CLK10.39085367
133ILK0.38709342
134HCK0.38093871
135BMX0.37255149
136MAPK40.37151128
137CSNK2A10.36947735
138CDK60.36128547
139MKNK10.35933439
140PRKG20.33245851
141MAP3K70.33223048
142JAK10.31427800
143RAF10.30832521

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.70239161
2Mismatch repair_Homo sapiens_hsa034304.45564403
3Base excision repair_Homo sapiens_hsa034103.34048386
4Ribosome_Homo sapiens_hsa030103.01550327
5Proteasome_Homo sapiens_hsa030502.98003234
6Spliceosome_Homo sapiens_hsa030402.94317540
7One carbon pool by folate_Homo sapiens_hsa006702.81413973
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81158583
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50579930
10Sulfur relay system_Homo sapiens_hsa041222.39601642
11Nucleotide excision repair_Homo sapiens_hsa034202.33496528
12Homologous recombination_Homo sapiens_hsa034402.33119578
13RNA transport_Homo sapiens_hsa030132.30374388
14Allograft rejection_Homo sapiens_hsa053302.30342306
15Graft-versus-host disease_Homo sapiens_hsa053322.15175438
16Autoimmune thyroid disease_Homo sapiens_hsa053202.10084816
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98104192
18Staphylococcus aureus infection_Homo sapiens_hsa051501.97488224
19Pyrimidine metabolism_Homo sapiens_hsa002401.96145548
20Cell cycle_Homo sapiens_hsa041101.92811109
21Biosynthesis of amino acids_Homo sapiens_hsa012301.78604224
22Non-homologous end-joining_Homo sapiens_hsa034501.69016389
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68734836
24Asthma_Homo sapiens_hsa053101.65916809
25RNA polymerase_Homo sapiens_hsa030201.64576219
26Pentose phosphate pathway_Homo sapiens_hsa000301.58333698
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.55087480
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.52133002
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51487906
30Viral myocarditis_Homo sapiens_hsa054161.49413735
31Rheumatoid arthritis_Homo sapiens_hsa053231.48264491
32Type I diabetes mellitus_Homo sapiens_hsa049401.42952747
33Other glycan degradation_Homo sapiens_hsa005111.35917946
34Carbon metabolism_Homo sapiens_hsa012001.34499948
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32567617
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.32094485
37Hematopoietic cell lineage_Homo sapiens_hsa046401.27861888
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.27144833
39Fructose and mannose metabolism_Homo sapiens_hsa000511.24466012
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22607689
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21507813
42Fanconi anemia pathway_Homo sapiens_hsa034601.16056055
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08897685
44Pancreatic cancer_Homo sapiens_hsa052121.08576246
45Collecting duct acid secretion_Homo sapiens_hsa049661.08484203
46Systemic lupus erythematosus_Homo sapiens_hsa053221.07652881
47TNF signaling pathway_Homo sapiens_hsa046681.06819155
48Epstein-Barr virus infection_Homo sapiens_hsa051691.06014843
49Bladder cancer_Homo sapiens_hsa052191.05821805
50Vibrio cholerae infection_Homo sapiens_hsa051101.01383257
51Galactose metabolism_Homo sapiens_hsa000521.01064164
52T cell receptor signaling pathway_Homo sapiens_hsa046601.00710356
53N-Glycan biosynthesis_Homo sapiens_hsa005101.00045428
54RNA degradation_Homo sapiens_hsa030180.99773960
55Malaria_Homo sapiens_hsa051440.98513910
56Legionellosis_Homo sapiens_hsa051340.96402065
57Antigen processing and presentation_Homo sapiens_hsa046120.95831407
58Sulfur metabolism_Homo sapiens_hsa009200.95407861
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94944718
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94657987
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.94065857
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93727615
63Salmonella infection_Homo sapiens_hsa051320.87480480
64Viral carcinogenesis_Homo sapiens_hsa052030.86740277
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85438358
66p53 signaling pathway_Homo sapiens_hsa041150.85344831
67Leishmaniasis_Homo sapiens_hsa051400.83250489
68Folate biosynthesis_Homo sapiens_hsa007900.82921517
69B cell receptor signaling pathway_Homo sapiens_hsa046620.82797088
70Chemokine signaling pathway_Homo sapiens_hsa040620.81599937
71mRNA surveillance pathway_Homo sapiens_hsa030150.80663713
72Hepatitis C_Homo sapiens_hsa051600.80560930
73Lysosome_Homo sapiens_hsa041420.77504758
74Purine metabolism_Homo sapiens_hsa002300.76785862
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.76607034
76VEGF signaling pathway_Homo sapiens_hsa043700.73858877
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72048127
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69755965
79Herpes simplex infection_Homo sapiens_hsa051680.69297024
80Apoptosis_Homo sapiens_hsa042100.68494216
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67901831
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.65749843
83Selenocompound metabolism_Homo sapiens_hsa004500.65701977
84Shigellosis_Homo sapiens_hsa051310.63908367
85Chronic myeloid leukemia_Homo sapiens_hsa052200.61725839
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59898784
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59848412
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59352011
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59127827
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59080632
91HTLV-I infection_Homo sapiens_hsa051660.58898563
92African trypanosomiasis_Homo sapiens_hsa051430.55797740
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54530823
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.53744610
95Primary immunodeficiency_Homo sapiens_hsa053400.53606838
96Hepatitis B_Homo sapiens_hsa051610.52903764
97Measles_Homo sapiens_hsa051620.52758818
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52628463
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.52373175
100HIF-1 signaling pathway_Homo sapiens_hsa040660.50685556
101Acute myeloid leukemia_Homo sapiens_hsa052210.49195438
102Pyruvate metabolism_Homo sapiens_hsa006200.48131412
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47977678
104Osteoclast differentiation_Homo sapiens_hsa043800.46828849
105Endocytosis_Homo sapiens_hsa041440.46651569
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44558019
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44412010
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43824513
109Prion diseases_Homo sapiens_hsa050200.42740322
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42564060
111Colorectal cancer_Homo sapiens_hsa052100.42560223
112mTOR signaling pathway_Homo sapiens_hsa041500.42389533
113Non-small cell lung cancer_Homo sapiens_hsa052230.41982626
114Lysine degradation_Homo sapiens_hsa003100.41661927
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40856295
116Influenza A_Homo sapiens_hsa051640.39323270
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37739671
118Alcoholism_Homo sapiens_hsa050340.36269979
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36020745
120Oocyte meiosis_Homo sapiens_hsa041140.35597785
121Pertussis_Homo sapiens_hsa051330.35544330
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35091694
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34675123
124Platelet activation_Homo sapiens_hsa046110.34613695
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.34330294
126Tuberculosis_Homo sapiens_hsa051520.34279146
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.32542246
128Small cell lung cancer_Homo sapiens_hsa052220.32225405
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31669399
130Glutathione metabolism_Homo sapiens_hsa004800.30868784
131Renin-angiotensin system_Homo sapiens_hsa046140.30741585
132Phagosome_Homo sapiens_hsa041450.28635459
133Thyroid cancer_Homo sapiens_hsa052160.26235748
134Parkinsons disease_Homo sapiens_hsa050120.24663609
135Notch signaling pathway_Homo sapiens_hsa043300.21856041
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20499101
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20069134
138Toxoplasmosis_Homo sapiens_hsa051450.19087815

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