CCDC28B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.55436553
2central nervous system myelination (GO:0022010)8.55436553
3fatty acid elongation (GO:0030497)6.24546857
4long-chain fatty acid biosynthetic process (GO:0042759)5.21177059
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.00412154
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.88209741
7myelination (GO:0042552)4.82653871
8axon ensheathment (GO:0008366)4.77400424
9ensheathment of neurons (GO:0007272)4.77400424
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.71879684
11ATP synthesis coupled proton transport (GO:0015986)4.71879684
12pyrimidine nucleobase catabolic process (GO:0006208)4.66506525
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.64142254
14neuron cell-cell adhesion (GO:0007158)4.63070176
15behavioral response to nicotine (GO:0035095)4.59720123
16presynaptic membrane assembly (GO:0097105)4.52623903
17presynaptic membrane organization (GO:0097090)4.51190255
18establishment of mitochondrion localization (GO:0051654)4.42740807
19cholesterol biosynthetic process (GO:0006695)4.40503376
20sequestering of actin monomers (GO:0042989)4.36731703
21platelet dense granule organization (GO:0060155)4.00606788
22protein neddylation (GO:0045116)3.99952959
23negative regulation of neurotransmitter transport (GO:0051589)3.99184495
24chaperone-mediated protein transport (GO:0072321)3.92587639
25sterol biosynthetic process (GO:0016126)3.87817678
26substantia nigra development (GO:0021762)3.82509042
27respiratory electron transport chain (GO:0022904)3.76783940
28regulation of collateral sprouting (GO:0048670)3.73259376
29electron transport chain (GO:0022900)3.66536691
30DNA strand renaturation (GO:0000733)3.63580721
31ubiquinone biosynthetic process (GO:0006744)3.62193884
32isoprenoid biosynthetic process (GO:0008299)3.61563837
33negative regulation of neurotransmitter secretion (GO:0046929)3.58719937
34ubiquinone metabolic process (GO:0006743)3.51976098
35nucleobase catabolic process (GO:0046113)3.51298589
36photoreceptor cell differentiation (GO:0046530)3.44858027
37eye photoreceptor cell differentiation (GO:0001754)3.44858027
38GPI anchor biosynthetic process (GO:0006506)3.37987388
39negative regulation of protein localization to cell surface (GO:2000009)3.36277984
40oligodendrocyte differentiation (GO:0048709)3.35762927
41transmission of nerve impulse (GO:0019226)3.34186931
42proteasome assembly (GO:0043248)3.32832529
43protein-cofactor linkage (GO:0018065)3.21642709
44ATP biosynthetic process (GO:0006754)3.20578675
45GPI anchor metabolic process (GO:0006505)3.19745691
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19274703
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19274703
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19226140
49neuron recognition (GO:0008038)3.18846685
50metallo-sulfur cluster assembly (GO:0031163)3.16989057
51iron-sulfur cluster assembly (GO:0016226)3.16989057
52DNA damage response, detection of DNA damage (GO:0042769)3.13446604
53neurotransmitter uptake (GO:0001504)3.11429674
54limb bud formation (GO:0060174)3.09193142
55DNA deamination (GO:0045006)3.08825046
56positive regulation of oligodendrocyte differentiation (GO:0048714)3.08029364
57mannosylation (GO:0097502)3.07723687
58glycerophospholipid catabolic process (GO:0046475)3.06632893
59neuronal action potential propagation (GO:0019227)3.05196743
60positive regulation of synapse assembly (GO:0051965)3.04822702
61ribosomal small subunit assembly (GO:0000028)3.03453281
62hydrogen ion transmembrane transport (GO:1902600)3.02624002
63regulation of dopamine metabolic process (GO:0042053)3.01454271
64regulation of catecholamine metabolic process (GO:0042069)3.01454271
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00343258
66positive regulation of action potential (GO:0045760)3.00328802
67dendritic spine morphogenesis (GO:0060997)2.98116734
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98116560
69respiratory chain complex IV assembly (GO:0008535)2.96649034
70regulation of feeding behavior (GO:0060259)2.96520504
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94809934
72preassembly of GPI anchor in ER membrane (GO:0016254)2.94314386
73long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.93784277
74apical protein localization (GO:0045176)2.92033702
75cytochrome complex assembly (GO:0017004)2.91802999
76anterograde synaptic vesicle transport (GO:0048490)2.90877483
77negative regulation of telomere maintenance (GO:0032205)2.89396362
78long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.87942794
79amyloid precursor protein metabolic process (GO:0042982)2.87850340
80neural nucleus development (GO:0048857)2.87500585
81cerebral cortex radially oriented cell migration (GO:0021799)2.87035802
82cell proliferation in forebrain (GO:0021846)2.85775169
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85461479
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.85461479
85NADH dehydrogenase complex assembly (GO:0010257)2.85461479
86regulation of mitochondrial translation (GO:0070129)2.85255080
87protein complex biogenesis (GO:0070271)2.83549173
88proton transport (GO:0015992)2.82567282
89pyrimidine nucleotide catabolic process (GO:0006244)2.81832259
90nonmotile primary cilium assembly (GO:0035058)2.79521941
91response to methylmercury (GO:0051597)2.79260705
92viral transcription (GO:0019083)2.78911524
93adult walking behavior (GO:0007628)2.78789999
94quinone biosynthetic process (GO:1901663)2.77885825
95dopamine biosynthetic process (GO:0042416)2.77778924
96hydrogen transport (GO:0006818)2.77205077
97protein localization to synapse (GO:0035418)2.75109818
98negative regulation of axonogenesis (GO:0050771)2.74215488
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74160257
100astrocyte development (GO:0014002)2.74108170
101protein polyglutamylation (GO:0018095)2.73697763
102inner mitochondrial membrane organization (GO:0007007)2.73095845
103translational termination (GO:0006415)2.72765659
104negative regulation of microtubule polymerization (GO:0031115)2.72413056
105protein palmitoylation (GO:0018345)2.71537299
106postsynaptic membrane organization (GO:0001941)2.70948287
107asymmetric protein localization (GO:0008105)2.70195890
108synaptic transmission, cholinergic (GO:0007271)2.69195331
109magnesium ion transport (GO:0015693)2.68986044
110cranial nerve development (GO:0021545)2.68231653
111intracellular protein transmembrane import (GO:0044743)2.67743538
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67724992
113oxidative phosphorylation (GO:0006119)2.67320452
114axonal fasciculation (GO:0007413)2.67136580
115response to redox state (GO:0051775)2.67123505
116positive regulation of mitochondrial fission (GO:0090141)2.66114849
117negative regulation of axon extension (GO:0030517)2.66104232
118mechanosensory behavior (GO:0007638)2.64853267
119mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.64454335
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62348050
121L-amino acid import (GO:0043092)2.62215784
122axon development (GO:0061564)2.62101508
123myelin maintenance (GO:0043217)2.61526066
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.61524448
125establishment of protein localization to mitochondrion (GO:0072655)2.61118453
126cornea development in camera-type eye (GO:0061303)2.60666236
127neural tube formation (GO:0001841)2.60347649
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.60150487
129mitochondrion transport along microtubule (GO:0047497)2.60150487
130ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59944488
131dendrite development (GO:0016358)2.59434191
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59109837
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58507838
134base-excision repair, AP site formation (GO:0006285)2.58353561
135epithelial cilium movement (GO:0003351)2.58040134
136synaptic vesicle exocytosis (GO:0016079)2.57997184
137glutamate receptor signaling pathway (GO:0007215)2.57872075
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54934703
139ionotropic glutamate receptor signaling pathway (GO:0035235)2.54855982
140nucleotide transmembrane transport (GO:1901679)2.54588539
141protein targeting to mitochondrion (GO:0006626)2.54367126
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54240301
143translational elongation (GO:0006414)2.54183387
144rRNA modification (GO:0000154)2.53469688
145termination of RNA polymerase III transcription (GO:0006386)2.51987485
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.51987485
147mitochondrial respiratory chain complex assembly (GO:0033108)2.50974335
148water-soluble vitamin biosynthetic process (GO:0042364)2.50073184
149cellular component biogenesis (GO:0044085)2.49737792
150negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.49003901
151ceramide biosynthetic process (GO:0046513)2.48873060
152neuron remodeling (GO:0016322)2.47854274
153protein localization to mitochondrion (GO:0070585)2.47579741
154regulation of cilium movement (GO:0003352)2.47478943
155regulation of action potential (GO:0098900)2.47325563
156C-terminal protein lipidation (GO:0006501)2.46406416
157glycolipid biosynthetic process (GO:0009247)2.46325831
158membrane assembly (GO:0071709)2.46117897
159retinal ganglion cell axon guidance (GO:0031290)2.46007224
160fatty-acyl-CoA metabolic process (GO:0035337)2.45870996
161membrane hyperpolarization (GO:0060081)2.45404922
162positive regulation of protein homodimerization activity (GO:0090073)2.44883448
163SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44294656
164intraciliary transport (GO:0042073)2.44247079
165cotranslational protein targeting to membrane (GO:0006613)2.43623536
166neuron fate determination (GO:0048664)2.43280659
167startle response (GO:0001964)2.43270697
168cerebellar granule cell differentiation (GO:0021707)2.42368385
169positive regulation of cellular amine metabolic process (GO:0033240)2.40572442
170negative regulation of execution phase of apoptosis (GO:1900118)2.40456816
171pyrimidine-containing compound catabolic process (GO:0072529)2.38318699
172protein targeting to ER (GO:0045047)2.37720336
173protein localization to cilium (GO:0061512)2.36738299
174GTP biosynthetic process (GO:0006183)2.36264436
175peptidyl-histidine modification (GO:0018202)2.35732240
176mitochondrial transport (GO:0006839)2.35007596
177negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34104994
178nucleoside triphosphate biosynthetic process (GO:0009142)2.33766185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45879033
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.96300880
3GBX2_23144817_ChIP-Seq_PC3_Human3.66439365
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.28835112
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21014192
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.99031445
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78801702
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.67005871
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62064457
10TAF15_26573619_Chip-Seq_HEK293_Human2.58338801
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49492940
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46523779
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.46034479
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39378305
15VDR_22108803_ChIP-Seq_LS180_Human2.33817483
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23550423
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22572788
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.20713116
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19485807
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19318280
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.17918838
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14442908
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14442908
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14430021
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12720129
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.10905154
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10092906
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.09513427
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08488546
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06023082
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03600658
32MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02796884
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98473948
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96995534
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95856253
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89955781
37VDR_23849224_ChIP-Seq_CD4+_Human1.86916596
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84879703
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.82477818
40FUS_26573619_Chip-Seq_HEK293_Human1.80638639
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.79716884
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78034100
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75134505
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74744139
45ER_23166858_ChIP-Seq_MCF-7_Human1.74639177
46MYC_18940864_ChIP-ChIP_HL60_Human1.72559000
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71237409
48REST_21632747_ChIP-Seq_MESCs_Mouse1.70194097
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63902325
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63616330
51IGF1R_20145208_ChIP-Seq_DFB_Human1.62752661
52RNF2_27304074_Chip-Seq_NSC_Mouse1.61467905
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.59705743
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58530798
55P300_19829295_ChIP-Seq_ESCs_Human1.57745720
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55898933
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50567420
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49685157
59AR_21572438_ChIP-Seq_LNCaP_Human1.49500332
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46360443
61ELK1_19687146_ChIP-ChIP_HELA_Human1.45051234
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44761393
63FOXP3_21729870_ChIP-Seq_TREG_Human1.44356374
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.39625768
65TP53_22573176_ChIP-Seq_HFKS_Human1.39448173
66* GABP_19822575_ChIP-Seq_HepG2_Human1.36301758
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35121916
68DROSHA_22980978_ChIP-Seq_HELA_Human1.34789799
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.34093655
70IRF1_19129219_ChIP-ChIP_H3396_Human1.34084931
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32733857
72CIITA_25753668_ChIP-Seq_RAJI_Human1.31301197
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28528212
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28398987
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28187611
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25791463
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24212534
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.22949834
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.22288268
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21512177
81EWS_26573619_Chip-Seq_HEK293_Human1.21459487
82TTF2_22483619_ChIP-Seq_HELA_Human1.19682267
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17446822
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15986638
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15909085
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15728644
87XRN2_22483619_ChIP-Seq_HELA_Human1.14153182
88ZNF274_21170338_ChIP-Seq_K562_Hela1.13509133
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13153091
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13097100
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.12035493
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11022813
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10156135
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09984483
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07925546
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.07450409
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07200202
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06970128
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06607807
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.04590420
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04485429
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04327176
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04218617
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.04083831
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03974638
106SMAD4_21799915_ChIP-Seq_A2780_Human1.01975091
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01711050
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01559750
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01466177
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01466177
111NCOR_22424771_ChIP-Seq_293T_Human1.01343002
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01204412
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.00219593
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.00076708
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99205124
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.97979589
117RARB_27405468_Chip-Seq_BRAIN_Mouse0.97969810
118KDM2B_26808549_Chip-Seq_REH_Human0.97150541
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.96825320
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95697558
121JUN_21703547_ChIP-Seq_K562_Human0.95426658
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95396851
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95093637
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94767348
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.93901790
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93670226
127HTT_18923047_ChIP-ChIP_STHdh_Human0.93084182
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92416888
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92082059
130CBP_20019798_ChIP-Seq_JUKART_Human0.92082059
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.91121745
132RUNX2_22187159_ChIP-Seq_PCA_Human0.91011681
133* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90901638
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90852335
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90617336
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89538096
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89359930
138NANOG_19829295_ChIP-Seq_ESCs_Human0.88996330
139SOX2_19829295_ChIP-Seq_ESCs_Human0.88996330
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88736625
141NANOG_20526341_ChIP-Seq_ESCs_Human0.88581809
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.87885524
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87523576
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86763585
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86497725
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86463838
147RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85762548
148DCP1A_22483619_ChIP-Seq_HELA_Human0.85006759
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84733623
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82520850
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82363090
152ERA_21632823_ChIP-Seq_H3396_Human0.82022100
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81816256
154MYC_19829295_ChIP-Seq_ESCs_Human0.81481772
155TAF2_19829295_ChIP-Seq_ESCs_Human0.81066452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.45814652
2MP0001529_abnormal_vocalization3.55777021
3MP0000920_abnormal_myelination3.36218299
4MP0005423_abnormal_somatic_nervous3.19575962
5MP0002822_catalepsy2.99129007
6MP0004270_analgesia2.86099331
7MP0001905_abnormal_dopamine_level2.74843574
8MP0003646_muscle_fatigue2.67286795
9MP0002272_abnormal_nervous_system2.66650887
10MP0001486_abnormal_startle_reflex2.56451703
11MP0005409_darkened_coat_color2.52674327
12MP0003787_abnormal_imprinting2.50814848
13MP0004742_abnormal_vestibular_system2.42004092
14MP0000778_abnormal_nervous_system2.41908910
15MP0003635_abnormal_synaptic_transmissio2.33008738
16MP0004859_abnormal_synaptic_plasticity2.28128522
17MP0002064_seizures2.22371936
18MP0002734_abnormal_mechanical_nocicepti2.20385248
19MP0006276_abnormal_autonomic_nervous2.13269101
20MP0004142_abnormal_muscle_tone2.11108999
21MP0009745_abnormal_behavioral_response2.08680283
22MP0005551_abnormal_eye_electrophysiolog2.06556673
23MP0009046_muscle_twitch2.00297378
24MP0009379_abnormal_foot_pigmentation2.00041118
25MP0003136_yellow_coat_color1.99552332
26MP0001485_abnormal_pinna_reflex1.98283091
27MP0008877_abnormal_DNA_methylation1.98000558
28MP0002572_abnormal_emotion/affect_behav1.97926015
29MP0001968_abnormal_touch/_nociception1.89011813
30MP0002063_abnormal_learning/memory/cond1.85040923
31MP0001986_abnormal_taste_sensitivity1.83728158
32MP0002653_abnormal_ependyma_morphology1.82115031
33MP0001984_abnormal_olfaction1.74694215
34MP0002736_abnormal_nociception_after1.71540002
35MP0006072_abnormal_retinal_apoptosis1.70385794
36MP0005084_abnormal_gallbladder_morpholo1.69920580
37MP0003634_abnormal_glial_cell1.69615970
38MP0002837_dystrophic_cardiac_calcinosis1.68660157
39MP0003690_abnormal_glial_cell1.68588807
40MP0002184_abnormal_innervation1.64675118
41MP0004885_abnormal_endolymph1.63465109
42MP0008995_early_reproductive_senescence1.62024281
43MP0001440_abnormal_grooming_behavior1.61397235
44MP0002067_abnormal_sensory_capabilities1.61152454
45MP0002229_neurodegeneration1.59882846
46MP0003329_amyloid_beta_deposits1.58689781
47MP0001970_abnormal_pain_threshold1.55892119
48MP0003950_abnormal_plasma_membrane1.54637202
49MP0002882_abnormal_neuron_morphology1.53349413
50MP0003121_genomic_imprinting1.52772753
51MP0002735_abnormal_chemical_nociception1.52277682
52MP0002733_abnormal_thermal_nociception1.50234935
53MP0001188_hyperpigmentation1.49183573
54MP0005645_abnormal_hypothalamus_physiol1.46174260
55MP0005386_behavior/neurological_phenoty1.45251575
56MP0004924_abnormal_behavior1.45251575
57MP0000955_abnormal_spinal_cord1.42790305
58MP0005171_absent_coat_pigmentation1.42244094
59MP0002752_abnormal_somatic_nervous1.40190698
60MP0002557_abnormal_social/conspecific_i1.36846858
61MP0006036_abnormal_mitochondrial_physio1.36088939
62MP0001963_abnormal_hearing_physiology1.33587127
63MP0000631_abnormal_neuroendocrine_gland1.30031767
64MP0002066_abnormal_motor_capabilities/c1.28913378
65MP0008569_lethality_at_weaning1.28068672
66MP0002638_abnormal_pupillary_reflex1.26122783
67MP0005253_abnormal_eye_physiology1.24555350
68MP0002234_abnormal_pharynx_morphology1.24340592
69MP0008058_abnormal_DNA_repair1.23241029
70MP0005195_abnormal_posterior_eye1.21501205
71MP0002102_abnormal_ear_morphology1.19023631
72MP0005410_abnormal_fertilization1.17272384
73MP0000372_irregular_coat_pigmentation1.17126582
74MP0000026_abnormal_inner_ear1.17062090
75MP0006035_abnormal_mitochondrial_morpho1.14338698
76MP0003632_abnormal_nervous_system1.13137674
77MP0003878_abnormal_ear_physiology1.11986486
78MP0005377_hearing/vestibular/ear_phenot1.11986486
79MP0001502_abnormal_circadian_rhythm1.10017530
80MP0002152_abnormal_brain_morphology1.07159553
81MP0000749_muscle_degeneration1.07123919
82MP0004134_abnormal_chest_morphology1.04844991
83MP0004381_abnormal_hair_follicle1.04297885
84MP0002938_white_spotting1.04192209
85MP0003938_abnormal_ear_development1.04147043
86MP0001501_abnormal_sleep_pattern1.03144958
87MP0000462_abnormal_digestive_system1.02935811
88MP0004147_increased_porphyrin_level0.97548002
89MP0005266_abnormal_metabolism0.94408789
90MP0001661_extended_life_span0.93777558
91MP0008789_abnormal_olfactory_epithelium0.93637722
92MP0004133_heterotaxia0.92784500
93MP0000566_synostosis0.92408015
94MP0004145_abnormal_muscle_electrophysio0.92083157
95MP0003631_nervous_system_phenotype0.91319645
96MP0005379_endocrine/exocrine_gland_phen0.91112636
97MP0003011_delayed_dark_adaptation0.90818066
98MP0002332_abnormal_exercise_endurance0.90407758
99MP0008872_abnormal_physiological_respon0.89028664
100MP0003137_abnormal_impulse_conducting0.86946979
101MP0005646_abnormal_pituitary_gland0.86297232
102MP0003122_maternal_imprinting0.86251575
103MP0002106_abnormal_muscle_physiology0.85296238
104MP0003186_abnormal_redox_activity0.84246658
105MP0004811_abnormal_neuron_physiology0.83207232
106MP0006292_abnormal_olfactory_placode0.82017163
107MP0002751_abnormal_autonomic_nervous0.81961849
108MP0001348_abnormal_lacrimal_gland0.81836247
109MP0000750_abnormal_muscle_regeneration0.78045132
110MP0005499_abnormal_olfactory_system0.77643634
111MP0005394_taste/olfaction_phenotype0.77643634
112MP0002090_abnormal_vision0.77596571
113MP0002928_abnormal_bile_duct0.77086501
114MP0000751_myopathy0.75398620
115MP0000013_abnormal_adipose_tissue0.74859483
116MP0003718_maternal_effect0.74432378
117MP0003633_abnormal_nervous_system0.73859871
118MP0003786_premature_aging0.73471680
119MP0002876_abnormal_thyroid_physiology0.72575264
120MP0003861_abnormal_nervous_system0.72167347
121MP0002095_abnormal_skin_pigmentation0.71896998
122MP0001299_abnormal_eye_distance/0.71275171
123MP0000015_abnormal_ear_pigmentation0.70283291
124MP0002163_abnormal_gland_morphology0.67485313
125MP0000049_abnormal_middle_ear0.64204334
126MP0004085_abnormal_heartbeat0.60305979
127MP0001346_abnormal_lacrimal_gland0.57995403
128MP0004043_abnormal_pH_regulation0.57736797

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.01236975
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.84279843
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.84279843
4Acute necrotizing encephalopathy (HP:0006965)4.40050533
5Neurofibrillary tangles (HP:0002185)4.36283741
6Abnormality of glycolysis (HP:0004366)3.87708580
7Increased serum pyruvate (HP:0003542)3.87708580
8Mitochondrial inheritance (HP:0001427)3.80917170
9Abnormal mitochondria in muscle tissue (HP:0008316)3.79865564
10Abnormality of the corticospinal tract (HP:0002492)3.72300623
11Progressive macrocephaly (HP:0004481)3.72075213
12Renal Fanconi syndrome (HP:0001994)3.62154545
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.57358950
14Acute encephalopathy (HP:0006846)3.41573703
15Retinal dysplasia (HP:0007973)3.35127256
163-Methylglutaconic aciduria (HP:0003535)3.33668523
17Increased hepatocellular lipid droplets (HP:0006565)3.33391655
18Myokymia (HP:0002411)3.33256314
19Leukodystrophy (HP:0002415)3.26558128
20Hepatocellular necrosis (HP:0001404)3.20135722
21Sensory axonal neuropathy (HP:0003390)3.19269677
22Molar tooth sign on MRI (HP:0002419)3.13014640
23Abnormality of midbrain morphology (HP:0002418)3.13014640
24Cerebral inclusion bodies (HP:0100314)3.02025328
25Spastic gait (HP:0002064)2.92736207
26Focal motor seizures (HP:0011153)2.85772012
27Supranuclear gaze palsy (HP:0000605)2.84788357
28Increased CSF lactate (HP:0002490)2.83936229
29Lipid accumulation in hepatocytes (HP:0006561)2.83662292
30Abnormal number of erythroid precursors (HP:0012131)2.81983676
31Pancreatic cysts (HP:0001737)2.81190883
32Pancreatic fibrosis (HP:0100732)2.80891885
33Peripheral hypomyelination (HP:0007182)2.77783491
34Optic disc pallor (HP:0000543)2.73869671
35Muscle fiber atrophy (HP:0100295)2.72834733
36True hermaphroditism (HP:0010459)2.72063288
37Hypoplastic pelvis (HP:0008839)2.69762934
38Nephronophthisis (HP:0000090)2.66985094
39Abnormality of the labia minora (HP:0012880)2.63241828
40Lactic acidosis (HP:0003128)2.62659871
41Gait imbalance (HP:0002141)2.57148106
42Ankle clonus (HP:0011448)2.54736339
43Increased muscle lipid content (HP:0009058)2.53325451
44Medial flaring of the eyebrow (HP:0010747)2.51972457
45Muscle fiber inclusion bodies (HP:0100299)2.51782456
46Abnormality of cells of the erythroid lineage (HP:0012130)2.50695736
47Congenital ichthyosiform erythroderma (HP:0007431)2.49033410
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47451925
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47451925
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47398875
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47279862
52Increased serum lactate (HP:0002151)2.46960324
53Akinesia (HP:0002304)2.46893060
54Atonic seizures (HP:0010819)2.46238952
55Epileptic encephalopathy (HP:0200134)2.44116544
56Limb dystonia (HP:0002451)2.43497183
57Lissencephaly (HP:0001339)2.37497674
58Nemaline bodies (HP:0003798)2.35561355
59Anteriorly placed anus (HP:0001545)2.35282925
60Chronic sinusitis (HP:0011109)2.31206521
61Vaginal atresia (HP:0000148)2.30165407
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29764269
63Colon cancer (HP:0003003)2.29216347
64Exercise-induced muscle cramps (HP:0003710)2.26221677
65Rib fusion (HP:0000902)2.26132780
66Cerebral hypomyelination (HP:0006808)2.25843798
67Genital tract atresia (HP:0001827)2.24699303
68Abnormality of renal resorption (HP:0011038)2.24360344
69Hepatic necrosis (HP:0002605)2.23575854
70Absent septum pellucidum (HP:0001331)2.23476925
71Chronic otitis media (HP:0000389)2.22982475
72Absent/shortened dynein arms (HP:0200106)2.21493796
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.21493796
74Patellar aplasia (HP:0006443)2.19063025
75Congenital primary aphakia (HP:0007707)2.17637259
76Pheochromocytoma (HP:0002666)2.17206062
77Hypoplastic left heart (HP:0004383)2.17054466
78Dysmetria (HP:0001310)2.16245814
79Respiratory difficulties (HP:0002880)2.14327369
80Hyperventilation (HP:0002883)2.13898500
81Abnormality of the renal medulla (HP:0100957)2.13145865
82Increased intramyocellular lipid droplets (HP:0012240)2.12114719
83Aplasia/Hypoplasia of the patella (HP:0006498)2.11751901
84Pachygyria (HP:0001302)2.11275699
85Nephrogenic diabetes insipidus (HP:0009806)2.08521984
86Rimmed vacuoles (HP:0003805)2.05442454
87Scanning speech (HP:0002168)2.04869304
88Neuroendocrine neoplasm (HP:0100634)2.04451705
89X-linked dominant inheritance (HP:0001423)2.03568639
90Focal seizures (HP:0007359)2.02746717
91Abnormality of the septum pellucidum (HP:0007375)2.02451800
92Broad-based gait (HP:0002136)2.02213844
93Respiratory failure (HP:0002878)2.02162613
94Chronic hepatic failure (HP:0100626)2.02152949
95Progressive inability to walk (HP:0002505)2.02137735
96Exertional dyspnea (HP:0002875)2.00993880
97Muscle hypertrophy of the lower extremities (HP:0008968)2.00482117
98Termporal pattern (HP:0011008)2.00170668
99Insidious onset (HP:0003587)2.00170668
100Abnormal respiratory epithelium morphology (HP:0012253)1.98324984
101Abnormal respiratory motile cilium morphology (HP:0005938)1.98324984
102Methylmalonic acidemia (HP:0002912)1.97469646
103Congenital stationary night blindness (HP:0007642)1.97421245
104Sclerocornea (HP:0000647)1.96953585
105Adrenal hypoplasia (HP:0000835)1.93712293
106Dicarboxylic aciduria (HP:0003215)1.92926304
107Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92926304
108Renal cortical cysts (HP:0000803)1.92800113
109Cerebral hemorrhage (HP:0001342)1.92699338
110Myelomeningocele (HP:0002475)1.92153257
111Alacrima (HP:0000522)1.92120304
112Anencephaly (HP:0002323)1.91978517
113Methylmalonic aciduria (HP:0012120)1.91752310
114Abolished electroretinogram (ERG) (HP:0000550)1.91400664
115Hypothermia (HP:0002045)1.91131476
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91113114
117Hyperglycinemia (HP:0002154)1.91105849
118Severe muscular hypotonia (HP:0006829)1.90486708
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89358156
120Hypoplasia of the brainstem (HP:0002365)1.89358156
121Progressive cerebellar ataxia (HP:0002073)1.89293953
122Intention tremor (HP:0002080)1.88833266
123Morphological abnormality of the inner ear (HP:0011390)1.88057035
124Abnormal ciliary motility (HP:0012262)1.87340351
125Dialeptic seizures (HP:0011146)1.86625124
126Exercise intolerance (HP:0003546)1.86225968
127Abnormality of the renal cortex (HP:0011035)1.85254629
128Cerebral edema (HP:0002181)1.84855307
129Distal arthrogryposis (HP:0005684)1.84248243
130Abnormality of macular pigmentation (HP:0008002)1.84247311
131Anomalous pulmonary venous return (HP:0010772)1.83790213
132Lethargy (HP:0001254)1.82914921
133Calf muscle hypertrophy (HP:0008981)1.82429535
134Split foot (HP:0001839)1.81968143
135Onion bulb formation (HP:0003383)1.81074456
136Increased corneal curvature (HP:0100692)1.80834055
137Keratoconus (HP:0000563)1.80834055
138Type II lissencephaly (HP:0007260)1.80632583
139Cupped ear (HP:0000378)1.79822803
140Synostosis involving the elbow (HP:0003938)1.79668554
141Humeroradial synostosis (HP:0003041)1.79668554
142Partial agenesis of the corpus callosum (HP:0001338)1.79432924
143Hemiparesis (HP:0001269)1.77858725
144Reticulocytopenia (HP:0001896)1.77235370
145Septo-optic dysplasia (HP:0100842)1.76718804
146Thickened helices (HP:0000391)1.75048464
147Emotional lability (HP:0000712)1.74776949
148Myotonia (HP:0002486)1.74694477
149Polyphagia (HP:0002591)1.74689074
150Growth hormone deficiency (HP:0000824)1.72994930
151Abnormality of urine glucose concentration (HP:0011016)1.72455855
152Glycosuria (HP:0003076)1.72455855
153Optic nerve hypoplasia (HP:0000609)1.72103545
154Progressive microcephaly (HP:0000253)1.71681460
155Hypoplastic heart (HP:0001961)1.71411600
156Large for gestational age (HP:0001520)1.70000983
157Poor suck (HP:0002033)1.69910222
158Optic nerve coloboma (HP:0000588)1.69905144
159Type 2 muscle fiber atrophy (HP:0003554)1.67512832
160Aplasia/hypoplasia of the uterus (HP:0008684)1.66933864
161Elevated erythrocyte sedimentation rate (HP:0003565)1.64974963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.24744327
2OXSR13.34905954
3VRK23.18603536
4TNIK3.18165320
5BCKDK2.87054384
6CASK2.72804201
7MARK12.71294944
8CDK192.55612324
9BCR2.52780173
10MAP4K22.44405172
11UHMK12.35281404
12PNCK2.27312662
13EPHB12.19191209
14ZAK2.18494383
15MAPKAPK52.11713790
16PINK12.10334773
17NUAK12.09733305
18MAPK132.09278996
19STK162.08303834
20CSNK1G32.06418686
21DYRK21.98026507
22PKN11.95591924
23CSNK1A1L1.69784450
24WNK41.69270860
25FGR1.68485078
26NTRK21.64548598
27PBK1.63139620
28CSNK1G21.57619973
29LIMK11.53958083
30CSNK1G11.51656881
31MAP2K71.44179810
32CAMK2B1.43523613
33DYRK31.40204142
34NME11.32717178
35FGFR21.29815102
36MUSK1.27335039
37BMPR1B1.26851829
38SRPK11.25631231
39TRIM281.22440270
40PHKG11.20874411
41PHKG21.20874411
42MAP2K41.19667994
43FRK1.18328926
44INSRR1.14846699
45MAP3K41.13789112
46ROCK21.08348455
47TAF11.05552714
48GRK71.05428940
49CAMK2D1.04301028
50CAMK2A1.02883229
51NTRK31.01921119
52PRPF4B1.01775769
53ARAF1.01754306
54CDK50.99049063
55NEK60.96407910
56EPHA40.95702804
57CLK10.94339005
58CDK140.94155866
59CDC70.93232979
60MARK20.91659056
61MKNK10.91348908
62WNK30.91240741
63AURKA0.89374332
64MAPK150.88999708
65WNK10.88601099
66DYRK1A0.88214214
67FES0.85789633
68CDK150.85380007
69GRK50.85188053
70CDK180.84158845
71PRKCE0.83983873
72SGK4940.83723880
73SGK2230.83723880
74PIM20.79876263
75CDK11A0.79418717
76TESK20.79124376
77KDR0.78220608
78CCNB10.77600497
79NTRK10.76485707
80YES10.76342315
81TYRO30.76014791
82TAOK30.75417121
83CAMK2G0.74499728
84MST40.73804524
85GRK10.72126771
86PAK60.69806659
87SIK20.68969914
88MET0.67590142
89MINK10.66332086
90ADRBK20.66306545
91EPHB20.65129587
92DYRK1B0.63441121
93ICK0.63365863
94VRK10.62183620
95MAP3K120.61621638
96PAK30.61355532
97PASK0.57244883
98RPS6KA50.56872089
99PRKCQ0.55811672
100PLK40.55801928
101ADRBK10.55637874
102PRKCG0.55354774
103BMPR20.53518712
104IRAK20.53387076
105PRKG10.51607314
106PIK3CG0.51441154
107BRSK10.50623858
108MAP3K110.50044077
109FYN0.48604705
110DAPK30.47809951
111MAPK40.47106817
112PRKACA0.47031342
113ATR0.46783054
114TIE10.46422707
115KIT0.46140552
116MAPK120.46092593
117SYK0.44473304
118CDK30.43752704
119PLK10.41771339
120CSNK2A10.41216434
121CSNK2A20.39313392
122OBSCN0.38985052
123PRKACB0.38973192
124BUB10.38251099
125NEK10.37942751
126MAP3K60.37723898
127HIPK20.36920096
128PLK30.36440855
129DAPK20.35678973
130PRKCZ0.35586816
131MARK30.35577531
132CSNK1A10.34196191
133ERBB30.33507782
134CSNK1E0.33362341
135TNK20.32993663
136PLK20.32193278
137CAMK1G0.30233990
138MYLK0.30143676
139CDK80.29228523
140CSNK1D0.28764624
141TLK10.27746070

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.45626203
2Oxidative phosphorylation_Homo sapiens_hsa001904.08950844
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.63885073
4Steroid biosynthesis_Homo sapiens_hsa001003.56883901
5Parkinsons disease_Homo sapiens_hsa050123.41654467
6Fatty acid elongation_Homo sapiens_hsa000623.07605479
7Alzheimers disease_Homo sapiens_hsa050102.89732408
8Protein export_Homo sapiens_hsa030602.85871522
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54272857
10Ether lipid metabolism_Homo sapiens_hsa005652.27802352
11Huntingtons disease_Homo sapiens_hsa050162.19262077
12Nicotine addiction_Homo sapiens_hsa050332.09745680
13Ribosome_Homo sapiens_hsa030101.96640859
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94328062
15Phototransduction_Homo sapiens_hsa047441.89573803
16GABAergic synapse_Homo sapiens_hsa047271.80374517
17Cardiac muscle contraction_Homo sapiens_hsa042601.79050707
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79001378
19Serotonergic synapse_Homo sapiens_hsa047261.78310451
20Glutamatergic synapse_Homo sapiens_hsa047241.74674965
21Homologous recombination_Homo sapiens_hsa034401.60074991
22Base excision repair_Homo sapiens_hsa034101.55540287
23Sphingolipid metabolism_Homo sapiens_hsa006001.49926675
24Fanconi anemia pathway_Homo sapiens_hsa034601.49409821
25Morphine addiction_Homo sapiens_hsa050321.48371283
26Axon guidance_Homo sapiens_hsa043601.46369832
27Primary immunodeficiency_Homo sapiens_hsa053401.46003053
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41766028
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40063924
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35254342
31Sulfur metabolism_Homo sapiens_hsa009201.33478296
32Collecting duct acid secretion_Homo sapiens_hsa049661.32422515
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31057524
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30931286
35Circadian entrainment_Homo sapiens_hsa047131.24874290
36Proteasome_Homo sapiens_hsa030501.22103406
37RNA polymerase_Homo sapiens_hsa030201.21977707
38Taste transduction_Homo sapiens_hsa047421.21925410
39Sulfur relay system_Homo sapiens_hsa041221.19275205
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19060281
41Mismatch repair_Homo sapiens_hsa034301.16344958
42Synaptic vesicle cycle_Homo sapiens_hsa047211.16138147
43Peroxisome_Homo sapiens_hsa041461.15978604
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15572752
45Butanoate metabolism_Homo sapiens_hsa006501.15041652
46Pyrimidine metabolism_Homo sapiens_hsa002401.14100082
47Dopaminergic synapse_Homo sapiens_hsa047281.13504925
48Long-term depression_Homo sapiens_hsa047301.11870708
49Vibrio cholerae infection_Homo sapiens_hsa051101.10915017
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09516993
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06051002
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.02312643
53DNA replication_Homo sapiens_hsa030301.01898413
54Linoleic acid metabolism_Homo sapiens_hsa005911.01532673
55Cocaine addiction_Homo sapiens_hsa050301.00314862
56Cholinergic synapse_Homo sapiens_hsa047250.99032365
57Olfactory transduction_Homo sapiens_hsa047400.93482119
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93463878
59Nucleotide excision repair_Homo sapiens_hsa034200.92466163
60RNA degradation_Homo sapiens_hsa030180.91357410
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89209133
62Spliceosome_Homo sapiens_hsa030400.86385869
63Systemic lupus erythematosus_Homo sapiens_hsa053220.83027034
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.81524551
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80314933
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78490227
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78242288
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77170313
69Amphetamine addiction_Homo sapiens_hsa050310.75965630
70Salivary secretion_Homo sapiens_hsa049700.74044062
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.73702591
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73433836
73beta-Alanine metabolism_Homo sapiens_hsa004100.70104229
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69650856
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.68082886
76Rheumatoid arthritis_Homo sapiens_hsa053230.67736572
77Alcoholism_Homo sapiens_hsa050340.67458004
78Long-term potentiation_Homo sapiens_hsa047200.66210125
79Nitrogen metabolism_Homo sapiens_hsa009100.65711363
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.65253904
81Tryptophan metabolism_Homo sapiens_hsa003800.65106881
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64299938
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63659446
84Renin secretion_Homo sapiens_hsa049240.62548172
85Renal cell carcinoma_Homo sapiens_hsa052110.62157706
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57112321
87Gastric acid secretion_Homo sapiens_hsa049710.56597567
88Histidine metabolism_Homo sapiens_hsa003400.56488342
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55616027
90Arachidonic acid metabolism_Homo sapiens_hsa005900.55016997
91Ras signaling pathway_Homo sapiens_hsa040140.54776074
92Calcium signaling pathway_Homo sapiens_hsa040200.54667099
93One carbon pool by folate_Homo sapiens_hsa006700.54121386
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53086272
95Insulin secretion_Homo sapiens_hsa049110.52699102
96Gap junction_Homo sapiens_hsa045400.51996997
97Metabolic pathways_Homo sapiens_hsa011000.50290278
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.49897890
99Type I diabetes mellitus_Homo sapiens_hsa049400.49389034
100Allograft rejection_Homo sapiens_hsa053300.48516889
101Dilated cardiomyopathy_Homo sapiens_hsa054140.48365484
102Phagosome_Homo sapiens_hsa041450.48306924
103Fatty acid metabolism_Homo sapiens_hsa012120.47357170
104Asthma_Homo sapiens_hsa053100.46660206
105Ovarian steroidogenesis_Homo sapiens_hsa049130.44227118
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42792533
107Oxytocin signaling pathway_Homo sapiens_hsa049210.41234082
108Basal transcription factors_Homo sapiens_hsa030220.40793924
109RNA transport_Homo sapiens_hsa030130.40028892
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40000238
111Autoimmune thyroid disease_Homo sapiens_hsa053200.39701889
112Carbon metabolism_Homo sapiens_hsa012000.39111368
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37253750
114Pancreatic secretion_Homo sapiens_hsa049720.36263354
115Biosynthesis of amino acids_Homo sapiens_hsa012300.35421174
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.35393048
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35179913
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34165190
119Melanogenesis_Homo sapiens_hsa049160.33799984
120Fatty acid degradation_Homo sapiens_hsa000710.33601601
121cAMP signaling pathway_Homo sapiens_hsa040240.33398403
122Hedgehog signaling pathway_Homo sapiens_hsa043400.33195300
123ErbB signaling pathway_Homo sapiens_hsa040120.32524506
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32443117
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.32346926
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31513993
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31054417
128Folate biosynthesis_Homo sapiens_hsa007900.30754962
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29340258
130Wnt signaling pathway_Homo sapiens_hsa043100.25867325
131Regulation of autophagy_Homo sapiens_hsa041400.25863237
132Tight junction_Homo sapiens_hsa045300.25226861
133Glutathione metabolism_Homo sapiens_hsa004800.25181457
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22361960
135Propanoate metabolism_Homo sapiens_hsa006400.22318493
136GnRH signaling pathway_Homo sapiens_hsa049120.22232083
137Endocytosis_Homo sapiens_hsa041440.21843390
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.21830632
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21322423
140Arginine and proline metabolism_Homo sapiens_hsa003300.20647001
141N-Glycan biosynthesis_Homo sapiens_hsa005100.18926672
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18576953
143Purine metabolism_Homo sapiens_hsa002300.17585593
144Pyruvate metabolism_Homo sapiens_hsa006200.16824927
145MAPK signaling pathway_Homo sapiens_hsa040100.16344563
146Non-homologous end-joining_Homo sapiens_hsa034500.16182129

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