CCDC36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.69383927
2establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)5.42803226
3proteasome assembly (GO:0043248)5.06623721
4fucose catabolic process (GO:0019317)4.93634891
5L-fucose metabolic process (GO:0042354)4.93634891
6L-fucose catabolic process (GO:0042355)4.93634891
7DNA damage response, detection of DNA damage (GO:0042769)4.60725657
8maturation of SSU-rRNA (GO:0030490)4.55383202
9ribosomal small subunit assembly (GO:0000028)4.54454395
10regulation of nuclear cell cycle DNA replication (GO:0033262)4.45182168
11centriole assembly (GO:0098534)4.39790108
12response to pheromone (GO:0019236)4.35930604
13peptidyl-arginine omega-N-methylation (GO:0035247)4.23522887
14DNA methylation involved in gamete generation (GO:0043046)4.22763171
15regulation of posttranscriptional gene silencing (GO:0060147)4.22640064
16regulation of gene silencing by miRNA (GO:0060964)4.22640064
17regulation of gene silencing by RNA (GO:0060966)4.22640064
18ribosomal small subunit biogenesis (GO:0042274)4.22534189
19regulation of cilium assembly (GO:1902017)4.21854324
20histone arginine methylation (GO:0034969)4.20911922
21kinetochore organization (GO:0051383)4.19446062
22DNA replication initiation (GO:0006270)4.17066550
23positive regulation of protein kinase C signaling (GO:0090037)4.06964512
24tRNA modification (GO:0006400)4.02386505
25interkinetic nuclear migration (GO:0022027)3.98339429
26diterpenoid biosynthetic process (GO:0016102)3.98259731
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.88386889
28kinetochore assembly (GO:0051382)3.85291416
29face development (GO:0060324)3.78529392
30DNA deamination (GO:0045006)3.73284755
31reflex (GO:0060004)3.72034386
32response to peptidoglycan (GO:0032494)3.69289365
33kynurenine metabolic process (GO:0070189)3.69149329
34superoxide anion generation (GO:0042554)3.68568660
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.67299312
36motile cilium assembly (GO:0044458)3.65449427
37regulation of protein heterodimerization activity (GO:0043497)3.61191838
38peptidyl-arginine N-methylation (GO:0035246)3.57618098
39peptidyl-arginine methylation (GO:0018216)3.57618098
40regulation of gene expression by genetic imprinting (GO:0006349)3.55516901
41negative regulation of telomere maintenance (GO:0032205)3.54971712
42indole-containing compound catabolic process (GO:0042436)3.54683541
43indolalkylamine catabolic process (GO:0046218)3.54683541
44tryptophan catabolic process (GO:0006569)3.54683541
45sulfation (GO:0051923)3.52772968
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44891149
47ubiquinone biosynthetic process (GO:0006744)3.42933094
48amine catabolic process (GO:0009310)3.41743632
49cellular biogenic amine catabolic process (GO:0042402)3.41743632
50meiotic chromosome segregation (GO:0045132)3.40498815
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40282236
52sequestering of actin monomers (GO:0042989)3.31028127
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30781536
54gamma-aminobutyric acid transport (GO:0015812)3.30263709
55detection of light stimulus involved in sensory perception (GO:0050962)3.29455403
56detection of light stimulus involved in visual perception (GO:0050908)3.29455403
57establishment or maintenance of bipolar cell polarity (GO:0061245)3.28995119
58establishment or maintenance of apical/basal cell polarity (GO:0035088)3.28995119
59activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.28016960
60indolalkylamine metabolic process (GO:0006586)3.24805728
61neuronal action potential (GO:0019228)3.24474617
62ubiquinone metabolic process (GO:0006743)3.23624403
63telomere maintenance via semi-conservative replication (GO:0032201)3.22949260
64omega-hydroxylase P450 pathway (GO:0097267)3.21233859
65negative regulation of DNA-dependent DNA replication (GO:2000104)3.19053669
66platelet dense granule organization (GO:0060155)3.18652658
67regulation of neurotransmitter uptake (GO:0051580)3.16867545
68nephron tubule morphogenesis (GO:0072078)3.16442532
69nephron epithelium morphogenesis (GO:0072088)3.16442532
70termination of RNA polymerase III transcription (GO:0006386)3.15671168
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.15671168
72regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.14972617
73regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.14972617
74polyketide metabolic process (GO:0030638)3.14144865
75doxorubicin metabolic process (GO:0044598)3.14144865
76daunorubicin metabolic process (GO:0044597)3.14144865
77tryptophan metabolic process (GO:0006568)3.13034171
78anterior/posterior axis specification, embryo (GO:0008595)3.12659783
79telomere maintenance via recombination (GO:0000722)3.12579975
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10384662
81primary amino compound metabolic process (GO:1901160)3.09661846
82cellular ketone body metabolic process (GO:0046950)3.09104735
83artery development (GO:0060840)3.05154958
84negative regulation of mast cell activation (GO:0033004)3.04497204
85mature B cell differentiation (GO:0002335)3.03558062
86dendritic cell chemotaxis (GO:0002407)3.03017642
87mature B cell differentiation involved in immune response (GO:0002313)3.02938361
88replication fork processing (GO:0031297)3.02456559
89ribosome biogenesis (GO:0042254)3.01057957
90protein polyglutamylation (GO:0018095)3.00384460
91rRNA modification (GO:0000154)2.99217333
92regulation of action potential (GO:0098900)2.98869388
93multicellular organism reproduction (GO:0032504)2.98253775
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.96808299
95NADH dehydrogenase complex assembly (GO:0010257)2.96808299
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96808299
97pituitary gland development (GO:0021983)2.96471027
98protein-cofactor linkage (GO:0018065)2.95537997
99regulation of stem cell maintenance (GO:2000036)2.94897305
100hypothalamus development (GO:0021854)2.92095394
101positive regulation of DNA-dependent DNA replication (GO:2000105)2.91399019
102positive regulation of cell cycle G2/M phase transition (GO:1902751)2.90778991
103positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.90778991
104mitotic cell cycle arrest (GO:0071850)2.90218558
105endoderm formation (GO:0001706)2.89016764
106secondary metabolite biosynthetic process (GO:0044550)2.87830224
107chromatin remodeling at centromere (GO:0031055)2.87425223
108indole-containing compound metabolic process (GO:0042430)2.86634344
109auditory receptor cell stereocilium organization (GO:0060088)2.85627201
110phosphatidylinositol acyl-chain remodeling (GO:0036149)2.85056630
111melanin biosynthetic process (GO:0042438)2.83787003
112trophoblast giant cell differentiation (GO:0060707)2.81258489
113cytochrome complex assembly (GO:0017004)2.80171288
114terpenoid biosynthetic process (GO:0016114)2.79673041
115sister chromatid cohesion (GO:0007062)2.78687401
116melanin metabolic process (GO:0006582)2.78445166
117behavioral response to ethanol (GO:0048149)2.78410962
118telomere maintenance via telomerase (GO:0007004)2.77501347
119mitotic recombination (GO:0006312)2.77245146
120ketone body metabolic process (GO:1902224)2.76962779
121telomere maintenance via telomere lengthening (GO:0010833)2.75710027
122protein complex biogenesis (GO:0070271)2.74885945
123neutrophil activation (GO:0042119)2.74682118
124ribonucleoprotein complex biogenesis (GO:0022613)2.74377633
125histone H4-K12 acetylation (GO:0043983)2.74160620
126serotonin metabolic process (GO:0042428)2.73572303
127regulation of double-strand break repair via homologous recombination (GO:0010569)2.73374278
128natural killer cell activation involved in immune response (GO:0002323)2.73354548
129presynaptic membrane assembly (GO:0097105)2.70819024
130protein K6-linked ubiquitination (GO:0085020)2.70284001
131dopamine transport (GO:0015872)2.69980843
132synapsis (GO:0007129)2.69245150
133protein import into peroxisome matrix (GO:0016558)2.69081293
134nonmotile primary cilium assembly (GO:0035058)2.68662832
135kidney morphogenesis (GO:0060993)2.67817967
136righting reflex (GO:0060013)2.67696948
137retinal cone cell development (GO:0046549)2.67575548
138rRNA catabolic process (GO:0016075)2.66871121
139quinone biosynthetic process (GO:1901663)2.66103441
140rhodopsin mediated signaling pathway (GO:0016056)2.65846675
141male meiosis I (GO:0007141)2.65694843
142positive regulation of action potential (GO:0045760)2.65260126
143neuronal stem cell maintenance (GO:0097150)2.64909756
144preassembly of GPI anchor in ER membrane (GO:0016254)2.63826819
145RNA-dependent DNA replication (GO:0006278)2.63577125
146cAMP catabolic process (GO:0006198)2.63410187
147viral transcription (GO:0019083)2.63344575
148piRNA metabolic process (GO:0034587)2.62627362
149notochord development (GO:0030903)2.62452916
150regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.61742111
151epithelial cilium movement (GO:0003351)2.61454056
152regulation of protein kinase A signaling (GO:0010738)2.61030746
153water-soluble vitamin biosynthetic process (GO:0042364)2.60299152
154spliceosomal snRNP assembly (GO:0000387)2.59678208
155dendritic cell migration (GO:0036336)2.59522357
156positive regulation of cellular amide metabolic process (GO:0034250)2.59485964
157negative regulation of reactive oxygen species metabolic process (GO:2000378)2.58936440
158positive regulation of fatty acid transport (GO:2000193)2.58894745
159regulation of glucokinase activity (GO:0033131)2.58627108
160regulation of hexokinase activity (GO:1903299)2.58627108
161granulocyte activation (GO:0036230)2.58599156
162rRNA processing (GO:0006364)2.58574669
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58296737
164RNA modification (GO:0009451)2.57024574
165DNA replication checkpoint (GO:0000076)2.56580144
166translational termination (GO:0006415)2.55341711
167inner ear receptor stereocilium organization (GO:0060122)2.55333369
168postsynaptic membrane organization (GO:0001941)2.55255069
169regulation of mesoderm development (GO:2000380)2.54631364
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53082976
171startle response (GO:0001964)2.52481509
172protein localization to cilium (GO:0061512)2.52220337
173mitochondrial respiratory chain complex assembly (GO:0033108)2.51770749
174cellular response to ATP (GO:0071318)2.51242913
175G-protein coupled receptor internalization (GO:0002031)2.50873976
176regulation of hippo signaling (GO:0035330)2.50187672
177renal tubule morphogenesis (GO:0061333)2.49993340
178respiratory chain complex IV assembly (GO:0008535)2.49471359
179negative regulation of sodium ion transport (GO:0010766)2.48689946
180parturition (GO:0007567)2.48382163
181fucosylation (GO:0036065)2.48084555
182cilium morphogenesis (GO:0060271)2.47777998
183synaptic transmission, cholinergic (GO:0007271)2.47298376
184negative regulation of interleukin-1 production (GO:0032692)2.45377803
185male meiosis (GO:0007140)2.43889206
186positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42836364
187adaptation of signaling pathway (GO:0023058)2.41049587
188organic cation transport (GO:0015695)2.40652949
189mannosylation (GO:0097502)2.40557137
190tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38689521
191RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.38689521
192cilium organization (GO:0044782)2.38402726
193energy coupled proton transport, down electrochemical gradient (GO:0015985)2.38122969
194ATP synthesis coupled proton transport (GO:0015986)2.38122969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28037457
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.11073836
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.11073836
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.11073836
5ZNF274_21170338_ChIP-Seq_K562_Hela4.35343795
6VDR_22108803_ChIP-Seq_LS180_Human3.74174129
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.63463991
8EZH2_22144423_ChIP-Seq_EOC_Human3.58951665
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.85483162
10IRF1_19129219_ChIP-ChIP_H3396_Human2.84210994
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80109368
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.73390643
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.70919981
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61176493
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42837723
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31682768
17IGF1R_20145208_ChIP-Seq_DFB_Human2.30201623
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24917483
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10866904
20POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.10479742
21NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.99376852
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98879960
23NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97778791
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93011292
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.91373679
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90387421
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85728849
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83406297
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.82217076
30ER_23166858_ChIP-Seq_MCF-7_Human1.79160931
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.77937029
32P300_19829295_ChIP-Seq_ESCs_Human1.76675118
33EWS_26573619_Chip-Seq_HEK293_Human1.76095683
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75422307
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74529256
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74476822
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73911058
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73727414
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71274857
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69175878
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.66632118
42TAF15_26573619_Chip-Seq_HEK293_Human1.65341246
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62514645
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61663205
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.61324741
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60955038
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60392205
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60163797
49BCAT_22108803_ChIP-Seq_LS180_Human1.58348945
50TP53_22573176_ChIP-Seq_HFKS_Human1.57818813
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54143859
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.53692167
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50602575
54* GATA3_21878914_ChIP-Seq_MCF-7_Human1.47042752
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46461019
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45905711
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45655051
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44950116
59REST_21632747_ChIP-Seq_MESCs_Mouse1.44746147
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44090991
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44090991
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.42878469
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42878469
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42417940
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42133572
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41762987
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41760918
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40129903
69AR_21572438_ChIP-Seq_LNCaP_Human1.40074811
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38237646
71AR_25329375_ChIP-Seq_VCAP_Human1.38223169
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37995247
73STAT3_23295773_ChIP-Seq_U87_Human1.36740318
74SOX2_19829295_ChIP-Seq_ESCs_Human1.36018425
75NANOG_19829295_ChIP-Seq_ESCs_Human1.36018425
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.35502315
77* TCF4_23295773_ChIP-Seq_U87_Human1.35483383
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34921777
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33063340
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32740947
81GATA1_22025678_ChIP-Seq_K562_Human1.32450417
82CBP_20019798_ChIP-Seq_JUKART_Human1.31791095
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31791095
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31286954
85GBX2_23144817_ChIP-Seq_PC3_Human1.31097752
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30252351
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29038278
88RNF2_27304074_Chip-Seq_NSC_Mouse1.29001369
89ELK1_19687146_ChIP-ChIP_HELA_Human1.28102219
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27126513
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27104411
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.27095317
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.26618917
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.26416808
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25861862
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25624008
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.25301088
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25105098
99SMAD4_21799915_ChIP-Seq_A2780_Human1.23845225
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23654145
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.23230085
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22839168
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22322381
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.21879313
105* HOXB7_26014856_ChIP-Seq_BT474_Human1.20692199
106RUNX2_22187159_ChIP-Seq_PCA_Human1.20453347
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20403397
108DCP1A_22483619_ChIP-Seq_HELA_Human1.19920349
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.19895245
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19842273
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18866534
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17360155
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17122130
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.16355417
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.15748715
116NCOR_22424771_ChIP-Seq_293T_Human1.15088636
117AR_20517297_ChIP-Seq_VCAP_Human1.14812203
118TCF4_22108803_ChIP-Seq_LS180_Human1.14572337
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14495068
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14285875
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14027621
122KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13744768
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.13736684
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13606838
125KAP1_27257070_Chip-Seq_ESCs_Mouse1.13356882
126EZH2_27294783_Chip-Seq_ESCs_Mouse1.13295014
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11650886
128DROSHA_22980978_ChIP-Seq_HELA_Human1.10879604
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10603924
130NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10551721
131PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09546499
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08610956
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08574568
134POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07105445
135YY1_21170310_ChIP-Seq_MESCs_Mouse1.06163961
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06085360
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05875638
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05830640
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05134379
140STAT3_18555785_ChIP-Seq_MESCs_Mouse1.04978629
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.04834693
142SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04396211
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04107003
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.03562274
145VDR_23849224_ChIP-Seq_CD4+_Human1.03339254
146NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03293294
147JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03283711
148* ERA_21632823_ChIP-Seq_H3396_Human1.02798892
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.02342305
150FOXH1_21741376_ChIP-Seq_EPCs_Human1.01841793
151FOXM1_23109430_ChIP-Seq_U2OS_Human1.00842590
152E2F1_18555785_Chip-Seq_ESCs_Mouse1.00405421
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00188099
154TAF2_19829295_ChIP-Seq_ESCs_Human1.00158223
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00065798
156XRN2_22483619_ChIP-Seq_HELA_Human1.00021376
157EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99616878
158* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99476937
159FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99431914
160NANOG_20526341_ChIP-Seq_ESCs_Human0.99259875
161P53_22387025_ChIP-Seq_ESCs_Mouse0.98476933
162GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97541495
163SRF_21415370_ChIP-Seq_HL-1_Mouse0.97513658
164SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97171799
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97153312
166KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96467654
167MYC_19829295_ChIP-Seq_ESCs_Human0.96369046
168BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96093049
169FUS_26573619_Chip-Seq_HEK293_Human0.95794620
170MYC_18940864_ChIP-ChIP_HL60_Human0.95710948
171MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95062328
172CRX_20693478_ChIP-Seq_RETINA_Mouse0.94878955
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94769984
174GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93534120
175TP63_19390658_ChIP-ChIP_HaCaT_Human0.93017074
176NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91862353
177P300_18555785_Chip-Seq_ESCs_Mouse0.90952288
178SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90839874
179SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90406672
180THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89268118
181GABP_17652178_ChIP-ChIP_JURKAT_Human0.88362771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color9.02490852
2MP0001188_hyperpigmentation5.60805319
3MP0005409_darkened_coat_color5.54511768
4MP0006292_abnormal_olfactory_placode3.75822974
5MP0005670_abnormal_white_adipose3.43292687
6MP0008877_abnormal_DNA_methylation3.27898893
7MP0003195_calcinosis3.25019681
8MP0005174_abnormal_tail_pigmentation3.18897393
9MP0000015_abnormal_ear_pigmentation3.02298722
10MP0000569_abnormal_digit_pigmentation2.80374926
11MP0009046_muscle_twitch2.72784097
12MP0002102_abnormal_ear_morphology2.68746299
13MP0009379_abnormal_foot_pigmentation2.66767530
14MP0008875_abnormal_xenobiotic_pharmacok2.56461912
15MP0005551_abnormal_eye_electrophysiolog2.47615742
16MP0001986_abnormal_taste_sensitivity2.46034293
17MP0002277_abnormal_respiratory_mucosa2.38717804
18MP0008872_abnormal_physiological_respon2.26300322
19MP0003646_muscle_fatigue2.22579939
20MP0003011_delayed_dark_adaptation2.13075779
21MP0005171_absent_coat_pigmentation2.12345005
22MP0001348_abnormal_lacrimal_gland2.12238228
23MP0009745_abnormal_behavioral_response2.11073280
24MP0008057_abnormal_DNA_replication2.08922451
25MP0006072_abnormal_retinal_apoptosis2.08043125
26MP0004885_abnormal_endolymph2.01834210
27MP0003283_abnormal_digestive_organ2.00163296
28MP0004381_abnormal_hair_follicle1.92919059
29MP0004147_increased_porphyrin_level1.92027497
30MP0002837_dystrophic_cardiac_calcinosis1.89440524
31MP0003693_abnormal_embryo_hatching1.87159821
32MP0002272_abnormal_nervous_system1.80227103
33MP0010094_abnormal_chromosome_stability1.74964988
34MP0001486_abnormal_startle_reflex1.74167169
35MP0005646_abnormal_pituitary_gland1.73277503
36MP0002876_abnormal_thyroid_physiology1.71793447
37MP0000858_altered_metastatic_potential1.71265530
38MP0008007_abnormal_cellular_replicative1.69638708
39MP0005423_abnormal_somatic_nervous1.66898286
40MP0004043_abnormal_pH_regulation1.65515001
41MP0004742_abnormal_vestibular_system1.65037997
42MP0004142_abnormal_muscle_tone1.64344153
43MP0005253_abnormal_eye_physiology1.62508202
44MP0002160_abnormal_reproductive_system1.62328032
45MP0001501_abnormal_sleep_pattern1.59258324
46MP0005645_abnormal_hypothalamus_physiol1.58893709
47MP0003941_abnormal_skin_development1.58024456
48MP0002733_abnormal_thermal_nociception1.55980525
49MP0003123_paternal_imprinting1.53622052
50MP0008058_abnormal_DNA_repair1.52826019
51MP0004145_abnormal_muscle_electrophysio1.50815305
52MP0000372_irregular_coat_pigmentation1.50024584
53MP0003111_abnormal_nucleus_morphology1.49753836
54MP0000516_abnormal_urinary_system1.49618721
55MP0005367_renal/urinary_system_phenotyp1.49618721
56MP0006276_abnormal_autonomic_nervous1.49185046
57MP0002572_abnormal_emotion/affect_behav1.45250218
58MP0001968_abnormal_touch/_nociception1.44394439
59MP0001970_abnormal_pain_threshold1.44283549
60MP0001835_abnormal_antigen_presentation1.37057124
61MP0002067_abnormal_sensory_capabilities1.36354288
62MP0003880_abnormal_central_pattern1.33834591
63MP0000427_abnormal_hair_cycle1.33741956
64MP0002064_seizures1.31669136
65MP0005410_abnormal_fertilization1.30635066
66MP0001485_abnormal_pinna_reflex1.29372307
67MP0009785_altered_susceptibility_to1.28540189
68MP0002148_abnormal_hypersensitivity_rea1.27541380
69MP0001905_abnormal_dopamine_level1.27364176
70MP0002938_white_spotting1.25627929
71MP0003077_abnormal_cell_cycle1.23098911
72MP0000230_abnormal_systemic_arterial1.22738237
73MP0002638_abnormal_pupillary_reflex1.20115047
74MP0005167_abnormal_blood-brain_barrier1.20033996
75MP0002557_abnormal_social/conspecific_i1.18251873
76MP0004782_abnormal_surfactant_physiolog1.18112216
77MP0002653_abnormal_ependyma_morphology1.14368694
78MP0002063_abnormal_learning/memory/cond1.14263731
79MP0003436_decreased_susceptibility_to1.13731519
80MP0004957_abnormal_blastocyst_morpholog1.12217304
81MP0005386_behavior/neurological_phenoty1.11651450
82MP0004924_abnormal_behavior1.11651450
83MP0004510_myositis1.10963254
84MP0008775_abnormal_heart_ventricle1.10634410
85MP0004130_abnormal_muscle_cell1.10108313
86MP0004215_abnormal_myocardial_fiber1.10008436
87MP0002249_abnormal_larynx_morphology1.09680108
88MP0000490_abnormal_crypts_of1.09402370
89MP0000631_abnormal_neuroendocrine_gland1.08655655
90MP0008995_early_reproductive_senescence1.07477511
91MP0002177_abnormal_outer_ear1.07217485
92MP0002928_abnormal_bile_duct1.06760797
93MP0003119_abnormal_digestive_system1.06167175
94MP0001440_abnormal_grooming_behavior1.06136263
95MP0001186_pigmentation_phenotype1.05347156
96MP0002735_abnormal_chemical_nociception1.04131369
97MP0002210_abnormal_sex_determination1.03622244
98MP0002734_abnormal_mechanical_nocicepti1.01318253
99MP0008789_abnormal_olfactory_epithelium1.01184434
100MP0001853_heart_inflammation1.00825247
101MP0003635_abnormal_synaptic_transmissio1.00404281
102MP0005248_abnormal_Harderian_gland0.99992705
103MP0003137_abnormal_impulse_conducting0.99316450
104MP0000371_diluted_coat_color0.98664381
105MP0002075_abnormal_coat/hair_pigmentati0.97457519
106MP0005000_abnormal_immune_tolerance0.96461172
107MP0002095_abnormal_skin_pigmentation0.94704432
108MP0009333_abnormal_splenocyte_physiolog0.94032702
109MP0002419_abnormal_innate_immunity0.93535458
110MP0003786_premature_aging0.92786151
111MP0005389_reproductive_system_phenotype0.92428489
112MP0005195_abnormal_posterior_eye0.92036048
113MP0010386_abnormal_urinary_bladder0.91865430
114MP0001119_abnormal_female_reproductive0.91771427
115MP0000026_abnormal_inner_ear0.89772538
116MP0001145_abnormal_male_reproductive0.87623777
117MP0001502_abnormal_circadian_rhythm0.87214106
118MP0005464_abnormal_platelet_physiology0.86327770
119MP0000049_abnormal_middle_ear0.86316342
120MP0002751_abnormal_autonomic_nervous0.86305738
121MP0002736_abnormal_nociception_after0.85858604
122MP0009697_abnormal_copulation0.85629792
123MP0005332_abnormal_amino_acid0.85495069
124MP0001984_abnormal_olfaction0.85370124
125MP0003878_abnormal_ear_physiology0.84578723
126MP0005377_hearing/vestibular/ear_phenot0.84578723
127MP0005379_endocrine/exocrine_gland_phen0.83327341
128MP0001756_abnormal_urination0.82528723
129MP0008932_abnormal_embryonic_tissue0.81569899
130MP0005394_taste/olfaction_phenotype0.80986745
131MP0005499_abnormal_olfactory_system0.80986745
132MP0002234_abnormal_pharynx_morphology0.78849659
133MP0003718_maternal_effect0.78602161
134MP0004133_heterotaxia0.78218406
135MP0002752_abnormal_somatic_nervous0.78096345
136MP0001324_abnormal_eye_pigmentation0.76891375
137MP0001529_abnormal_vocalization0.76853449
138MP0003252_abnormal_bile_duct0.74567084
139MP0009764_decreased_sensitivity_to0.73986065
140MP0002452_abnormal_antigen_presenting0.73954892
141MP0005025_abnormal_response_to0.73849262
142MP0000566_synostosis0.73276339
143MP0005671_abnormal_response_to0.72168823
144MP0001929_abnormal_gametogenesis0.71300440
145MP0001963_abnormal_hearing_physiology0.70914093
146MP0000383_abnormal_hair_follicle0.70880280
147MP0002693_abnormal_pancreas_physiology0.70704146
148MP0001919_abnormal_reproductive_system0.70688745
149MP0000613_abnormal_salivary_gland0.70389056
150MP0002138_abnormal_hepatobiliary_system0.70331529
151MP0010329_abnormal_lipoprotein_level0.68959929
152MP0002398_abnormal_bone_marrow0.68292963
153MP0005084_abnormal_gallbladder_morpholo0.66998926
154MP0003724_increased_susceptibility_to0.66900442
155MP0003787_abnormal_imprinting0.65826046
156MP0003186_abnormal_redox_activity0.65803828
157MP0003698_abnormal_male_reproductive0.65328316
158MP0002723_abnormal_immune_serum0.65305927
159MP0000653_abnormal_sex_gland0.65162305
160MP0002233_abnormal_nose_morphology0.63674520
161MP0001819_abnormal_immune_cell0.63014841
162MP0002420_abnormal_adaptive_immunity0.61841450
163MP0001286_abnormal_eye_development0.61434232
164MP0006082_CNS_inflammation0.60412671
165MP0003937_abnormal_limbs/digits/tail_de0.59702452
166MP0003448_altered_tumor_morphology0.58372868
167MP0004883_abnormal_blood_vessel0.58287936
168MP0001800_abnormal_humoral_immune0.58250927
169MP0000681_abnormal_thyroid_gland0.56861358
170MP0003936_abnormal_reproductive_system0.56395232
171MP0003828_pulmonary_edema0.54514027
172MP0000716_abnormal_immune_system0.54335666
173MP0001293_anophthalmia0.54198448
174MP0009765_abnormal_xenobiotic_induced0.53525648
175MP0002163_abnormal_gland_morphology0.53124547
176MP0005408_hypopigmentation0.52309621
177MP0002722_abnormal_immune_system0.49627222

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)6.06499930
2Sex reversal (HP:0012245)6.06499930
3Pancreatic cysts (HP:0001737)4.76982750
4Septo-optic dysplasia (HP:0100842)4.71899275
5Pancreatic fibrosis (HP:0100732)4.50499377
6Abnormality of midbrain morphology (HP:0002418)4.39279084
7Molar tooth sign on MRI (HP:0002419)4.39279084
8True hermaphroditism (HP:0010459)4.25961139
9Optic nerve hypoplasia (HP:0000609)4.18881408
10Congenital stationary night blindness (HP:0007642)4.16131761
11Rib fusion (HP:0000902)3.96998909
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.95888646
13Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.92614674
14Nephronophthisis (HP:0000090)3.87959374
15Missing ribs (HP:0000921)3.87138664
16Abnormality of the axillary hair (HP:0100134)3.82204298
17Abnormality of secondary sexual hair (HP:0009888)3.82204298
18Type II lissencephaly (HP:0007260)3.60761013
19Meckel diverticulum (HP:0002245)3.55831118
20Congenital, generalized hypertrichosis (HP:0004540)3.55254193
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38874932
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.38796768
23Abnormality of the preputium (HP:0100587)3.34278469
24Generalized myoclonic seizures (HP:0002123)3.33154281
25Hyperventilation (HP:0002883)3.32762867
26Maternal diabetes (HP:0009800)3.31885689
27Abnormality of the ileum (HP:0001549)3.31226374
28Abnormality of the renal medulla (HP:0100957)3.29080859
29Abnormality of alanine metabolism (HP:0010916)3.19594190
30Hyperalaninemia (HP:0003348)3.19594190
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19594190
32Chromsome breakage (HP:0040012)3.17090518
33Inability to walk (HP:0002540)3.09956298
34Reduced antithrombin III activity (HP:0001976)3.09305222
35Abnormality of chromosome stability (HP:0003220)3.08520002
36Supernumerary bones of the axial skeleton (HP:0009144)3.06108357
37Cystic liver disease (HP:0006706)3.05348776
38Stomatitis (HP:0010280)3.04754632
39Attenuation of retinal blood vessels (HP:0007843)3.03778169
40Abnormal drinking behavior (HP:0030082)3.02800522
41Polydipsia (HP:0001959)3.02800522
42Large for gestational age (HP:0001520)3.00213359
43Type I transferrin isoform profile (HP:0003642)2.97430967
44Keratoconus (HP:0000563)2.97100054
45Increased corneal curvature (HP:0100692)2.97100054
46Focal motor seizures (HP:0011153)2.95729155
47Nonprogressive disorder (HP:0003680)2.95597032
48Pendular nystagmus (HP:0012043)2.95230406
49Abnormality of the renal cortex (HP:0011035)2.94009313
50Retrobulbar optic neuritis (HP:0100654)2.93319825
51Optic neuritis (HP:0100653)2.93319825
52Supernumerary ribs (HP:0005815)2.90012208
53Absent septum pellucidum (HP:0001331)2.86840255
54Decreased circulating renin level (HP:0003351)2.86262166
55Concave nail (HP:0001598)2.83278118
56Medial flaring of the eyebrow (HP:0010747)2.79231195
57Furrowed tongue (HP:0000221)2.78845449
58Abolished electroretinogram (ERG) (HP:0000550)2.74458340
59Recurrent abscess formation (HP:0002722)2.71494180
60Short middle phalanx of the 5th finger (HP:0004220)2.71003427
61Clumsiness (HP:0002312)2.68427189
62Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.67993243
63Abnormality of the septum pellucidum (HP:0007375)2.67620143
64Decreased central vision (HP:0007663)2.66869344
65Clubbing of toes (HP:0100760)2.66564287
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.65370945
67Hypoplasia of the fovea (HP:0007750)2.65370945
68Cerebellar dysplasia (HP:0007033)2.65215532
69Sclerocornea (HP:0000647)2.64109662
70Tubular atrophy (HP:0000092)2.63063325
71Abnormality of the labia minora (HP:0012880)2.53904904
72Supernumerary spleens (HP:0009799)2.52836514
73Adrenal hypoplasia (HP:0000835)2.52713998
74Hypoplasia of the radius (HP:0002984)2.52153936
75Mediastinal lymphadenopathy (HP:0100721)2.51213580
76Tracheoesophageal fistula (HP:0002575)2.51116297
77Myelodysplasia (HP:0002863)2.50181217
78Abnormal rod and cone electroretinograms (HP:0008323)2.49547585
79Polyuria (HP:0000103)2.46035704
80Mesangial abnormality (HP:0001966)2.44346679
81Gonadal dysgenesis (HP:0000133)2.42518340
82Progressive inability to walk (HP:0002505)2.40498909
83Distal lower limb muscle weakness (HP:0009053)2.40112447
84Chronic hepatic failure (HP:0100626)2.40096226
85Birth length less than 3rd percentile (HP:0003561)2.40058491
86Genetic anticipation (HP:0003743)2.39908741
87Impulsivity (HP:0100710)2.39558799
88Stomach cancer (HP:0012126)2.39221809
89Gait imbalance (HP:0002141)2.38865090
90Progressive cerebellar ataxia (HP:0002073)2.36387116
91Prolonged neonatal jaundice (HP:0006579)2.34534435
92Aplastic anemia (HP:0001915)2.33660871
93Severe muscular hypotonia (HP:0006829)2.33277323
94Congenital hepatic fibrosis (HP:0002612)2.29605069
95Eczematoid dermatitis (HP:0000976)2.28934419
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.28271844
97Broad-based gait (HP:0002136)2.27720214
98Gaze-evoked nystagmus (HP:0000640)2.27325481
99Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27137632
100Anencephaly (HP:0002323)2.26261975
101Absent thumb (HP:0009777)2.26177095
102Chorioretinal atrophy (HP:0000533)2.25810772
103Protruding tongue (HP:0010808)2.24532187
104Recurrent gram-negative bacterial infections (HP:0005420)2.23446819
105Duodenal stenosis (HP:0100867)2.23178634
106Small intestinal stenosis (HP:0012848)2.23178634
107Congenital primary aphakia (HP:0007707)2.22191558
108Abdominal situs inversus (HP:0003363)2.19443158
109Abnormality of abdominal situs (HP:0011620)2.19443158
110Recurrent bacterial skin infections (HP:0005406)2.19186248
111Breast hypoplasia (HP:0003187)2.16207219
112Obstructive sleep apnea (HP:0002870)2.13715791
113Spinal cord lesions (HP:0100561)2.13248838
114Syringomyelia (HP:0003396)2.13248838
115Reticulocytopenia (HP:0001896)2.13043560
116Male pseudohermaphroditism (HP:0000037)2.11445419
117Bone marrow hypocellularity (HP:0005528)2.10474052
118Orchitis (HP:0100796)2.10049780
119Lissencephaly (HP:0001339)2.09622373
120Aplasia/Hypoplasia of the patella (HP:0006498)2.08870142
121Renal cortical cysts (HP:0000803)2.08805376
122Nephrogenic diabetes insipidus (HP:0009806)2.07076276
123Aplasia/Hypoplasia of the tibia (HP:0005772)2.06206598
124Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05597457
125Abnormality of macrophages (HP:0004311)2.00510123
126Prostate neoplasm (HP:0100787)2.00376678
127Generalized hypopigmentation of hair (HP:0011358)1.99792217
128Basal ganglia calcification (HP:0002135)1.99419765
129Abnormal urine output (HP:0012590)1.99124569
130Abnormality of the pons (HP:0007361)1.98706971
131Amaurosis fugax (HP:0100576)1.97990524
132Abnormality of the carotid arteries (HP:0005344)1.96741917
133Partial agenesis of the corpus callosum (HP:0001338)1.96315126
134Absent radius (HP:0003974)1.96177199
135Triphalangeal thumb (HP:0001199)1.95662617
136Esophageal atresia (HP:0002032)1.94514351
137Conical tooth (HP:0000698)1.91179144
138Postaxial foot polydactyly (HP:0001830)1.90688547
139Absent/shortened dynein arms (HP:0200106)1.88151015
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.88151015
141Abnormality of the vertebral endplates (HP:0005106)1.87865752
142Tachypnea (HP:0002789)1.87524550
143Hypoplasia of the pons (HP:0012110)1.87123724
144Breast aplasia (HP:0100783)1.86020326
145Absent forearm bone (HP:0003953)1.84517108
146Aplasia involving forearm bones (HP:0009822)1.84517108
147Hemivertebrae (HP:0002937)1.83862973
148Abnormality of the clitoris (HP:0000056)1.83670971
149Abnormal biliary tract physiology (HP:0012439)1.83536205
150Bile duct proliferation (HP:0001408)1.83536205
151Poor head control (HP:0002421)1.82932325
152Febrile seizures (HP:0002373)1.82374043
153Granulocytopenia (HP:0001913)1.81897745
154Abnormality of renin-angiotensin system (HP:0000847)1.81510147
155Abnormality of the duodenum (HP:0002246)1.80262191
156Hypopigmented skin patches (HP:0001053)1.80253134
157Optic disc pallor (HP:0000543)1.79522022
158Asplenia (HP:0001746)1.79348070
159Bony spicule pigmentary retinopathy (HP:0007737)1.79095347
160Abnormality of the fovea (HP:0000493)1.79049664
161Prominent supraorbital ridges (HP:0000336)1.78582292
162Capillary hemangiomas (HP:0005306)1.76767485
163Hypogonadotrophic hypogonadism (HP:0000044)1.76658763
164Occipital encephalocele (HP:0002085)1.76100420
165Aplasia/hypoplasia of the uterus (HP:0008684)1.75967360
166Anterior segment dysgenesis (HP:0007700)1.74863741
167Hemiparesis (HP:0001269)1.74209275
168Forearm undergrowth (HP:0009821)1.73551708
169Abnormal respiratory motile cilium morphology (HP:0005938)1.73451420
170Abnormal respiratory epithelium morphology (HP:0012253)1.73451420
171Vertebral fusion (HP:0002948)1.72978054
172Abnormality of renal excretion (HP:0011036)1.72609393
173Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72579358
174Retinal dysplasia (HP:0007973)1.72352057
175Agnosia (HP:0010524)1.71756865
176Duplicated collecting system (HP:0000081)1.71601056
177Patellar aplasia (HP:0006443)1.71392051
178Gastrointestinal atresia (HP:0002589)1.71365113
179Ulnar claw (HP:0001178)1.70307466
180Hypothermia (HP:0002045)1.70085761
181Acute necrotizing encephalopathy (HP:0006965)1.69947823
182Abnormality of the renal collecting system (HP:0004742)1.69203273
183Increased CSF lactate (HP:0002490)1.67972142
184Genital tract atresia (HP:0001827)1.67729294
185Irregular vertebral endplates (HP:0003301)1.67445353
186Fair hair (HP:0002286)1.67031818
187Obstructive lung disease (HP:0006536)1.66878725
188Chronic obstructive pulmonary disease (HP:0006510)1.66878725
189Dysmetria (HP:0001310)1.66655768
190Aplasia/Hypoplasia involving the musculature (HP:0001460)1.66630962
191Mitochondrial inheritance (HP:0001427)1.66544119
192Pachygyria (HP:0001302)1.66469446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.21342529
2CASK3.34962799
3ACVR1B3.24767006
4GRK13.19836182
5WNK43.07840053
6STK162.85850665
7TAOK32.77197036
8NME22.71881210
9AKT32.53909057
10MAP4K22.38174642
11BCKDK2.28474947
12NUAK12.25639817
13CLK112.5285991
14WNK31.93326852
15MAP3K141.75492582
16DAPK21.71090664
17OXSR11.70031613
18BMPR21.66467181
19TGFBR11.64495274
20IRAK31.64178629
21RPS6KB21.59923005
22PNCK1.52320039
23MKNK21.47462326
24IRAK41.45805992
25YES11.45146483
26SRPK11.42580967
27VRK11.40567098
28STK391.38090378
29EPHA21.37330291
30ADRBK11.34131038
31RIPK41.27374784
32WEE11.26282689
33PLK41.23760876
34MAP3K41.22437026
35PIK3CA1.16397692
36PAK31.15397755
37TXK1.13756796
38PHKG11.12916158
39PHKG21.12916158
40MAPK151.08694577
41MKNK11.07374742
42MARK11.05245157
43MAP2K21.00195102
44STK380.95703991
45MAPKAPK30.92804136
46WNK10.92515639
47BUB10.89967206
48PTK2B0.87490579
49EIF2AK20.86956036
50MAP4K10.86386040
51MUSK0.84375979
52PRKCG0.82540941
53MAP2K10.80469459
54PRKCE0.80089292
55IKBKB0.78395753
56ZAK0.75589501
57ERBB30.74475583
58MAPKAPK50.72426688
59CDK70.71922506
60PRKD20.71490516
61GRK70.71148430
62PRPF4B0.70336527
63CAMKK20.67914712
64BRSK20.67118194
65KDR0.67028811
66CSNK1G20.66863525
67PIM10.66607606
68ITK0.65228645
69OBSCN0.63979674
70TRPM70.61079567
71NEK20.60999597
72CDC70.60567611
73STK110.60060154
74PRKCQ0.59575701
75BMX0.59267265
76PLK20.58224956
77PINK10.57936334
78EIF2AK30.56251415
79UHMK10.55904601
80PAK60.55624543
81STK38L0.54965348
82MAP2K60.54728549
83PKN10.54504053
84TEC0.54400512
85PLK30.54314842
86PLK10.53750093
87MAP3K10.53680488
88TNIK0.53436026
89BRD40.50811918
90CSNK1G30.50405907
91ADRBK20.47644809
92NTRK30.47015993
93TTK0.46979673
94RPS6KA60.46318680
95SIK30.46288542
96LYN0.46118492
97CHUK0.45845041
98MAP2K70.44737267
99PRKACA0.44646762
100CSNK1G10.44496293
101EPHB20.43569630
102RPS6KA40.42948379
103INSRR0.42783559
104TLK10.41215108
105ALK0.40447657
106NEK60.39887576
107GRK60.39407231
108NTRK20.38061774
109BTK0.37159946
110TIE10.36699130
111TNK20.36393068
112GRK50.36217072
113KIT0.36130477
114CSNK1A1L0.35772223
115JAK30.35611814
116ATR0.35207220
117SGK20.34842363
118DYRK20.34835334
119FLT30.34572929
120ABL10.34091127
121PRKCD0.33932699
122PRKG20.33119154
123DYRK30.32891788
124MAPK130.32796029
125PRKG10.32653323
126CSNK1D0.32287752
127EIF2AK10.32255794
128PRKAA10.31274317
129MAP3K110.30969589
130PRKCA0.30764033
131EPHA40.29869144
132PRKAA20.29649179
133PRKCI0.28740646
134NLK0.28486907
135MET0.28413984
136SGK30.28329251
137CSK0.27934683
138BMPR1B0.27712103
139CSNK2A10.27489131
140AURKB0.27485028
141CAMK10.27425093
142LCK0.27068727
143CAMK2B0.26363616
144CAMKK10.25926577
145CAMK2A0.25469445
146BLK0.24908467
147NME10.24737721
148SIK20.24710279
149CSNK2A20.24401452
150MAP3K120.24038527
151SYK0.23682228
152AKT10.22590074
153ABL20.22286129
154PDK20.22150679
155PIM20.21386598
156BCR0.21080565
157FES0.20177737
158IRAK10.19418933
159RPS6KA50.19308847
160IKBKE0.19025170
161ATM0.18963413
162STK240.17956382
163ERBB40.17647233
164JAK20.17380801
165LATS20.16238034

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01019192
2Ribosome_Homo sapiens_hsa030103.96428552
3Homologous recombination_Homo sapiens_hsa034403.53921124
4RNA polymerase_Homo sapiens_hsa030203.34740253
5Fanconi anemia pathway_Homo sapiens_hsa034603.14540650
6Phototransduction_Homo sapiens_hsa047443.11158008
7Spliceosome_Homo sapiens_hsa030402.97162428
8DNA replication_Homo sapiens_hsa030302.94356837
9One carbon pool by folate_Homo sapiens_hsa006702.83322599
10Nitrogen metabolism_Homo sapiens_hsa009102.82634133
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.70342113
12Mismatch repair_Homo sapiens_hsa034302.57330464
13RNA transport_Homo sapiens_hsa030132.14139860
14Caffeine metabolism_Homo sapiens_hsa002322.11723337
15Pyrimidine metabolism_Homo sapiens_hsa002402.07820810
16Graft-versus-host disease_Homo sapiens_hsa053322.02633113
17Butanoate metabolism_Homo sapiens_hsa006501.97721794
18Protein export_Homo sapiens_hsa030601.91850566
19RNA degradation_Homo sapiens_hsa030181.82143528
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.81136565
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74792686
22Cell cycle_Homo sapiens_hsa041101.67494230
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67458691
24Type I diabetes mellitus_Homo sapiens_hsa049401.67101211
25Base excision repair_Homo sapiens_hsa034101.65989812
26Tryptophan metabolism_Homo sapiens_hsa003801.59503430
27Parkinsons disease_Homo sapiens_hsa050121.58179711
28Thyroid cancer_Homo sapiens_hsa052161.55139347
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55024515
30Arachidonic acid metabolism_Homo sapiens_hsa005901.50676558
31Basal transcription factors_Homo sapiens_hsa030221.50362854
32Cardiac muscle contraction_Homo sapiens_hsa042601.48820290
33Allograft rejection_Homo sapiens_hsa053301.43980717
34Olfactory transduction_Homo sapiens_hsa047401.39185660
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38239188
36Phenylalanine metabolism_Homo sapiens_hsa003601.35866612
37Nicotine addiction_Homo sapiens_hsa050331.35713433
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33099893
39Peroxisome_Homo sapiens_hsa041461.30491762
40Leishmaniasis_Homo sapiens_hsa051401.28766216
41Rheumatoid arthritis_Homo sapiens_hsa053231.28562535
42ABC transporters_Homo sapiens_hsa020101.25945136
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.25814732
44Purine metabolism_Homo sapiens_hsa002301.20938170
45Linoleic acid metabolism_Homo sapiens_hsa005911.20656775
46Ether lipid metabolism_Homo sapiens_hsa005651.19878675
47Nucleotide excision repair_Homo sapiens_hsa034201.18684791
48Ovarian steroidogenesis_Homo sapiens_hsa049131.18237014
49p53 signaling pathway_Homo sapiens_hsa041151.16900440
50Non-homologous end-joining_Homo sapiens_hsa034501.16459731
51Proteasome_Homo sapiens_hsa030501.10637658
52Fat digestion and absorption_Homo sapiens_hsa049751.09284362
53Vitamin digestion and absorption_Homo sapiens_hsa049771.08003216
54Regulation of autophagy_Homo sapiens_hsa041401.07663282
55Serotonergic synapse_Homo sapiens_hsa047261.07364280
56Circadian entrainment_Homo sapiens_hsa047131.07246384
57Chemical carcinogenesis_Homo sapiens_hsa052041.03436404
58Glutamatergic synapse_Homo sapiens_hsa047241.02071457
59GABAergic synapse_Homo sapiens_hsa047271.01508883
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00975961
61Insulin secretion_Homo sapiens_hsa049111.00240428
62mRNA surveillance pathway_Homo sapiens_hsa030150.98422656
63Alzheimers disease_Homo sapiens_hsa050100.96167991
64Measles_Homo sapiens_hsa051620.95191779
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.93643294
66Propanoate metabolism_Homo sapiens_hsa006400.91479910
67Phagosome_Homo sapiens_hsa041450.89662076
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89596919
69Histidine metabolism_Homo sapiens_hsa003400.88582282
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87572373
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87421250
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87330842
73Primary immunodeficiency_Homo sapiens_hsa053400.87320709
74Wnt signaling pathway_Homo sapiens_hsa043100.86547846
75Herpes simplex infection_Homo sapiens_hsa051680.85513323
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.82965197
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81166806
78Glycerolipid metabolism_Homo sapiens_hsa005610.79794596
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.78366865
80Epstein-Barr virus infection_Homo sapiens_hsa051690.77469193
81Collecting duct acid secretion_Homo sapiens_hsa049660.77393113
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76814059
83Huntingtons disease_Homo sapiens_hsa050160.76288008
84Salivary secretion_Homo sapiens_hsa049700.75380364
85Retinol metabolism_Homo sapiens_hsa008300.73814133
86Sulfur metabolism_Homo sapiens_hsa009200.73169655
87Calcium signaling pathway_Homo sapiens_hsa040200.72746761
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72444889
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71910620
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71870393
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71398944
92Vibrio cholerae infection_Homo sapiens_hsa051100.70481545
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69907675
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.68896964
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68741187
96Mineral absorption_Homo sapiens_hsa049780.68007547
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67771590
98African trypanosomiasis_Homo sapiens_hsa051430.66325594
99beta-Alanine metabolism_Homo sapiens_hsa004100.65564553
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65297188
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63992485
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63615888
103Oxidative phosphorylation_Homo sapiens_hsa001900.63583537
104TNF signaling pathway_Homo sapiens_hsa046680.62117711
105Hematopoietic cell lineage_Homo sapiens_hsa046400.61390980
106Legionellosis_Homo sapiens_hsa051340.60910596
107Arginine biosynthesis_Homo sapiens_hsa002200.59366287
108Autoimmune thyroid disease_Homo sapiens_hsa053200.56624622
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53958755
110Asthma_Homo sapiens_hsa053100.53447785
111Sulfur relay system_Homo sapiens_hsa041220.52538759
112Gastric acid secretion_Homo sapiens_hsa049710.51642634
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51429486
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.50570499
115Circadian rhythm_Homo sapiens_hsa047100.50327432
116Hepatitis B_Homo sapiens_hsa051610.49224326
117Dopaminergic synapse_Homo sapiens_hsa047280.49058565
118Tyrosine metabolism_Homo sapiens_hsa003500.48310868
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.46940363
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46503190
121Tuberculosis_Homo sapiens_hsa051520.45989513
122Long-term depression_Homo sapiens_hsa047300.45839997
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44080001
124Metabolic pathways_Homo sapiens_hsa011000.44035333
125Synaptic vesicle cycle_Homo sapiens_hsa047210.43196614
126Cholinergic synapse_Homo sapiens_hsa047250.43134883
127Cocaine addiction_Homo sapiens_hsa050300.42356896
128cAMP signaling pathway_Homo sapiens_hsa040240.42235243
129Staphylococcus aureus infection_Homo sapiens_hsa051500.41793884
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41413164
131Oxytocin signaling pathway_Homo sapiens_hsa049210.40967518
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40413721
133Malaria_Homo sapiens_hsa051440.39877868
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38182432
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36636218
136Pertussis_Homo sapiens_hsa051330.35946584
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35163348
138Influenza A_Homo sapiens_hsa051640.34999032
139Bile secretion_Homo sapiens_hsa049760.34453448
140MicroRNAs in cancer_Homo sapiens_hsa052060.34116300
141Apoptosis_Homo sapiens_hsa042100.33873128
142Other glycan degradation_Homo sapiens_hsa005110.32804526
143Morphine addiction_Homo sapiens_hsa050320.30182259
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29911594
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26538075
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.25909042
147Taste transduction_Homo sapiens_hsa047420.25793834
148Viral carcinogenesis_Homo sapiens_hsa052030.25057707
149Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22839624
150Amphetamine addiction_Homo sapiens_hsa050310.22749682
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22676377
152Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22473200
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21486010
154Osteoclast differentiation_Homo sapiens_hsa043800.21189035
155Selenocompound metabolism_Homo sapiens_hsa004500.19816528

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