CCDC39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cilium movement (GO:0003341)9.44051610
2motile cilium assembly (GO:0044458)8.70428423
3* epithelial cilium movement (GO:0003351)8.53940468
4fusion of sperm to egg plasma membrane (GO:0007342)7.86384982
5piRNA metabolic process (GO:0034587)7.55098917
6* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.43703359
7sperm motility (GO:0030317)7.27878215
8acrosome assembly (GO:0001675)6.69468833
9multicellular organism reproduction (GO:0032504)6.66982787
10male meiosis (GO:0007140)6.62385893
11acrosome reaction (GO:0007340)6.41380358
12plasma membrane fusion (GO:0045026)6.27206607
13ventricular system development (GO:0021591)6.15911379
14regulation of cilium movement (GO:0003352)6.05745340
15sperm-egg recognition (GO:0035036)6.05038059
16axoneme assembly (GO:0035082)5.96148882
17synaptonemal complex organization (GO:0070193)5.78032062
18spermatid development (GO:0007286)5.73428776
19binding of sperm to zona pellucida (GO:0007339)5.38917568
20intraciliary transport (GO:0042073)5.32967460
21cell-cell recognition (GO:0009988)5.32879915
22protein localization to cilium (GO:0061512)5.18268689
23reproduction (GO:0000003)5.17299873
24cell wall macromolecule catabolic process (GO:0016998)5.11901459
25cell wall macromolecule metabolic process (GO:0044036)5.11901459
26male meiosis I (GO:0007141)5.06598589
27retinal rod cell development (GO:0046548)5.06044631
28synaptonemal complex assembly (GO:0007130)5.05024758
29DNA methylation involved in gamete generation (GO:0043046)4.89182199
30retinal cone cell development (GO:0046549)4.88146957
31negative regulation of inclusion body assembly (GO:0090084)4.85424148
32single fertilization (GO:0007338)4.75701794
33calcium ion-dependent exocytosis (GO:0017156)4.31950030
34cilium organization (GO:0044782)4.29546559
35sperm capacitation (GO:0048240)4.23247247
36cilium assembly (GO:0042384)4.18280172
37fertilization (GO:0009566)4.12103560
38primary alcohol catabolic process (GO:0034310)3.97599530
39meiosis I (GO:0007127)3.97502466
40left/right axis specification (GO:0070986)3.96186003
41vitamin transmembrane transport (GO:0035461)3.94616672
42* microtubule-based movement (GO:0007018)3.87294604
43regulation of microtubule-based movement (GO:0060632)3.86550475
44centriole assembly (GO:0098534)3.86525852
45left/right pattern formation (GO:0060972)3.74882704
46nucleoside diphosphate phosphorylation (GO:0006165)3.74646446
47one-carbon compound transport (GO:0019755)3.72722756
48regulation of germinal center formation (GO:0002634)3.72587106
49pyrimidine-containing compound transmembrane transport (GO:0072531)3.66131036
50cilium morphogenesis (GO:0060271)3.65970711
51cellular component assembly involved in morphogenesis (GO:0010927)3.64647714
52diterpenoid biosynthetic process (GO:0016102)3.64349082
53GTP biosynthetic process (GO:0006183)3.59474794
54lateral ventricle development (GO:0021670)3.56468689
55regulation of inclusion body assembly (GO:0090083)3.55691156
56microtubule polymerization or depolymerization (GO:0031109)3.53567703
57meiotic nuclear division (GO:0007126)3.53163199
58spermatogenesis (GO:0007283)3.52525419
59male gamete generation (GO:0048232)3.50713875
60cell recognition (GO:0008037)3.47471856
61protein polyglutamylation (GO:0018095)3.46322669
62negative regulation of B cell mediated immunity (GO:0002713)3.45827025
63negative regulation of immunoglobulin mediated immune response (GO:0002890)3.45827025
64ethanol metabolic process (GO:0006067)3.40390314
65chromosome organization involved in meiosis (GO:0070192)3.39984212
66germ cell development (GO:0007281)3.33772001
67centriole replication (GO:0007099)3.32789105
68neuron cell-cell adhesion (GO:0007158)3.30626564
69microtubule severing (GO:0051013)3.30198646
70microtubule bundle formation (GO:0001578)3.27971983
71cellular process involved in reproduction in multicellular organism (GO:0022412)3.26151928
72neural tube formation (GO:0001841)3.25967651
73interkinetic nuclear migration (GO:0022027)3.24161567
74gamete generation (GO:0007276)3.23105283
75smoothened signaling pathway (GO:0007224)3.17910643
76vocalization behavior (GO:0071625)3.15348308
77spermatid nucleus differentiation (GO:0007289)3.13236405
78meiotic cell cycle (GO:0051321)3.12730595
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11792199
80tolerance induction (GO:0002507)3.10085107
81protein localization to synapse (GO:0035418)3.09860369
82photoreceptor cell maintenance (GO:0045494)3.07381723
83seminiferous tubule development (GO:0072520)3.07379281
84response to xenobiotic stimulus (GO:0009410)3.04022917
85UTP biosynthetic process (GO:0006228)3.00926158
86cytoplasmic microtubule organization (GO:0031122)3.00802839
87* determination of left/right symmetry (GO:0007368)2.96458144
88negative regulation of humoral immune response (GO:0002921)2.95906789
89negative regulation of organelle assembly (GO:1902116)2.92348331
90membrane depolarization during action potential (GO:0086010)2.92232986
91synaptic vesicle exocytosis (GO:0016079)2.91845987
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.91375728
93regulation of meiosis I (GO:0060631)2.91235791
94epithelial cell differentiation involved in kidney development (GO:0035850)2.90253650
95regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89920094
96glomerular epithelial cell development (GO:0072310)2.88737350
97negative regulation of T cell differentiation in thymus (GO:0033085)2.88648418
98regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86451639
99* determination of bilateral symmetry (GO:0009855)2.85613335
100lung epithelium development (GO:0060428)2.84962987
101organelle assembly (GO:0070925)2.84411427
102regulation of interleukin-5 production (GO:0032674)2.84383566
103positive regulation of tolerance induction (GO:0002645)2.79900409
104positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78958530
105presynaptic membrane assembly (GO:0097105)2.78311183
106* specification of symmetry (GO:0009799)2.77208579
107nucleus localization (GO:0051647)2.74444349
108cell projection assembly (GO:0030031)2.74263269
109nonmotile primary cilium assembly (GO:0035058)2.74023357
110regulation of collateral sprouting (GO:0048670)2.72013855
111neuronal action potential propagation (GO:0019227)2.69706436
112microtubule depolymerization (GO:0007019)2.67966342
113* microtubule-based process (GO:0007017)2.67848745
114calcium ion import (GO:0070509)2.66033209
115establishment of planar polarity (GO:0001736)2.65085089
116establishment of tissue polarity (GO:0007164)2.65085089
117regulation of glutamate receptor signaling pathway (GO:1900449)2.64839368
118retinoic acid metabolic process (GO:0042573)2.63891183
119glutamate receptor signaling pathway (GO:0007215)2.63278910
120synaptic transmission, glutamatergic (GO:0035249)2.63255587
121lactate metabolic process (GO:0006089)2.62083931
122ethanol oxidation (GO:0006069)2.61771705
123central nervous system myelination (GO:0022010)2.61739801
124axon ensheathment in central nervous system (GO:0032291)2.61739801
125UTP metabolic process (GO:0046051)2.61237360
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59825751
127lateral sprouting from an epithelium (GO:0060601)2.59241960
128genitalia morphogenesis (GO:0035112)2.56543181
129glutamate secretion (GO:0014047)2.56494500
130regulation of centriole replication (GO:0046599)2.53697881
131neuron fate determination (GO:0048664)2.53371773
132multicellular organismal reproductive process (GO:0048609)2.52967121
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51107517
134presynaptic membrane organization (GO:0097090)2.49480046
135locomotory exploration behavior (GO:0035641)2.49358375
136neuron-neuron synaptic transmission (GO:0007270)2.49019757
137regulation of synaptic vesicle exocytosis (GO:2000300)2.46707902
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45613927
139histone H3-K9 demethylation (GO:0033169)2.43944907
140intra-S DNA damage checkpoint (GO:0031573)2.40012742
141neuronal stem cell maintenance (GO:0097150)2.37728961
142spinal cord motor neuron differentiation (GO:0021522)2.35775665
143exogenous drug catabolic process (GO:0042738)2.32106470
144regulation of smoothened signaling pathway (GO:0008589)2.30570253
145regulation of interleukin-13 production (GO:0032656)2.30083898
146limb development (GO:0060173)2.29957825
147appendage development (GO:0048736)2.29957825
148polyol transport (GO:0015791)2.27799086
149otic vesicle formation (GO:0030916)2.27385950
150* heart looping (GO:0001947)2.24660777
151brain morphogenesis (GO:0048854)2.24652562
152negative regulation of JUN kinase activity (GO:0043508)2.23436756
153positive regulation of smoothened signaling pathway (GO:0045880)2.23157804
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.21617010
155regulation of female gonad development (GO:2000194)2.20824315
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.19744023
157hydrogen peroxide biosynthetic process (GO:0050665)2.18833270
158terpenoid biosynthetic process (GO:0016114)2.18565145
159regulation of secondary heart field cardioblast proliferation (GO:0003266)2.17017844
160regulation of cardioblast proliferation (GO:0003264)2.17017844
161establishment of monopolar cell polarity (GO:0061162)2.16484296
162establishment or maintenance of monopolar cell polarity (GO:0061339)2.16484296
163establishment of nucleus localization (GO:0040023)2.15684895
164* cilium or flagellum-dependent cell motility (GO:0001539)13.9745403
165* axonemal dynein complex assembly (GO:0070286)10.2804118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45700372
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.26291647
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37559151
4GBX2_23144817_ChIP-Seq_PC3_Human2.72941440
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37819662
6TAF15_26573619_Chip-Seq_HEK293_Human2.28381056
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.18337393
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15772965
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12553852
10REST_21632747_ChIP-Seq_MESCs_Mouse2.06570088
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06505067
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.04048466
13AR_21572438_ChIP-Seq_LNCaP_Human2.03835495
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00127320
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99468575
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94258657
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94186904
18IGF1R_20145208_ChIP-Seq_DFB_Human1.86165092
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85746056
20ZNF274_21170338_ChIP-Seq_K562_Hela1.85412577
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80153063
22FOXM1_26456572_ChIP-Seq_MCF-7_Human1.78198530
23RNF2_27304074_Chip-Seq_NSC_Mouse1.76472091
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.76298010
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73138091
26SMAD4_21799915_ChIP-Seq_A2780_Human1.72178713
27EWS_26573619_Chip-Seq_HEK293_Human1.67422085
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65913982
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65826968
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65753022
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63104527
32TP53_16413492_ChIP-PET_HCT116_Human1.61939918
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61657006
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57319802
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.56900771
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55188233
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.54519311
38DROSHA_22980978_ChIP-Seq_HELA_Human1.53981959
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.52568583
40FUS_26573619_Chip-Seq_HEK293_Human1.52099867
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51173594
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50255592
43P300_19829295_ChIP-Seq_ESCs_Human1.49889625
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49251422
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49120123
46AHR_22903824_ChIP-Seq_MCF-7_Human1.47711677
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46672598
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45229432
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.44747507
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44525113
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.43948131
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.41999533
53ER_23166858_ChIP-Seq_MCF-7_Human1.41804934
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41269248
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41240623
56TP53_18474530_ChIP-ChIP_U2OS_Human1.40393777
57VDR_22108803_ChIP-Seq_LS180_Human1.40230163
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39441811
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39441811
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.38649765
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37583756
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37018919
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36824436
64* TCF4_23295773_ChIP-Seq_U87_Human1.36052500
65TCF4_22108803_ChIP-Seq_LS180_Human1.32354647
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31190058
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30752383
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30599401
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30599401
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30095641
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29956933
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29882447
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28702157
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.28136739
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27780596
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.27663851
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27142508
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.26681003
79STAT3_23295773_ChIP-Seq_U87_Human1.26653521
80* PRDM14_20953172_ChIP-Seq_ESCs_Human1.25494534
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25365972
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25298875
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25283931
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.23871925
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23548052
86KDM2B_26808549_Chip-Seq_REH_Human1.23100985
87BCAT_22108803_ChIP-Seq_LS180_Human1.22636195
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22379697
89ELK4_26923725_Chip-Seq_MESODERM_Mouse1.21675765
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21512035
91CBP_20019798_ChIP-Seq_JUKART_Human1.21512035
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20906256
93TP63_23658742_ChIP-Seq_EP156T_Human1.20547563
94P53_22387025_ChIP-Seq_ESCs_Mouse1.19608619
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19202165
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18915005
97SMRT_27268052_Chip-Seq_Bcells_Human1.18492421
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18378749
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.18207461
100RARB_27405468_Chip-Seq_BRAIN_Mouse1.17414281
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.17000152
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.16314454
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15719718
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15437727
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15333821
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15145873
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.14039715
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13318614
109TBL1_22424771_ChIP-Seq_293T_Human1.12349200
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12247204
111AR_25329375_ChIP-Seq_VCAP_Human1.11851974
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11681014
113ETV1_20927104_ChIP-Seq_GIST48_Human1.11584656
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11003122
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.09998679
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09448651
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09025085
118P300_18555785_Chip-Seq_ESCs_Mouse1.08715542
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.08658812
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08526451
121NANOG_19829295_ChIP-Seq_ESCs_Human1.08500682
122SOX2_19829295_ChIP-Seq_ESCs_Human1.08500682
123* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08312252
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.08272605
125RUNX2_22187159_ChIP-Seq_PCA_Human1.06450721
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.06041141
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.05965230
128CDX2_22108803_ChIP-Seq_LS180_Human1.05599282
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05244711
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.05011921
131CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04444838
132WDR5_24793694_ChIP-Seq_LNCAP_Human1.03873929
133RXR_22108803_ChIP-Seq_LS180_Human1.02910192
134* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02378431
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01224847
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00902642
137NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00343177
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00343177
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99999456
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99030113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.16818038
2MP0008877_abnormal_DNA_methylation3.76651521
3MP0008875_abnormal_xenobiotic_pharmacok3.53181679
4MP0003880_abnormal_central_pattern3.52709738
5MP0009046_muscle_twitch3.50739430
6MP0004859_abnormal_synaptic_plasticity3.39619425
7MP0002277_abnormal_respiratory_mucosa3.37652214
8MP0003698_abnormal_male_reproductive3.34741015
9MP0008789_abnormal_olfactory_epithelium3.26842703
10MP0002132_abnormal_respiratory_system3.21358641
11MP0001929_abnormal_gametogenesis2.82223390
12MP0002653_abnormal_ependyma_morphology2.71262936
13MP0004270_analgesia2.71069873
14MP0003635_abnormal_synaptic_transmissio2.68266570
15MP0004043_abnormal_pH_regulation2.61989773
16MP0001984_abnormal_olfaction2.49088443
17MP0009745_abnormal_behavioral_response2.41836035
18MP0005623_abnormal_meninges_morphology2.36026280
19MP0000566_synostosis2.35203561
20MP0001968_abnormal_touch/_nociception2.30369117
21MP0002064_seizures2.25913044
22MP0002063_abnormal_learning/memory/cond2.14526324
23MP0002572_abnormal_emotion/affect_behav2.13852310
24MP0001486_abnormal_startle_reflex2.08929215
25MP0002736_abnormal_nociception_after2.07211529
26MP0002210_abnormal_sex_determination2.05191951
27MP0002272_abnormal_nervous_system2.01031040
28MP0001440_abnormal_grooming_behavior1.96912418
29MP0005423_abnormal_somatic_nervous1.95881479
30MP0002734_abnormal_mechanical_nocicepti1.91858408
31MP0000383_abnormal_hair_follicle1.91207847
32MP0000778_abnormal_nervous_system1.81738632
33MP0002161_abnormal_fertility/fecundity1.76865374
34MP0002928_abnormal_bile_duct1.76265406
35MP0005646_abnormal_pituitary_gland1.71733488
36MP0002735_abnormal_chemical_nociception1.68138909
37MP0003890_abnormal_embryonic-extraembry1.66817920
38MP0003787_abnormal_imprinting1.65956279
39MP0005551_abnormal_eye_electrophysiolog1.63242347
40MP0001145_abnormal_male_reproductive1.63197085
41MP0010678_abnormal_skin_adnexa1.62880355
42MP0003646_muscle_fatigue1.61096251
43MP0001501_abnormal_sleep_pattern1.59208770
44MP0002067_abnormal_sensory_capabilities1.59145685
45MP0001293_anophthalmia1.56736946
46MP0002557_abnormal_social/conspecific_i1.56372735
47MP0006292_abnormal_olfactory_placode1.55104997
48MP0002160_abnormal_reproductive_system1.53393809
49MP0006276_abnormal_autonomic_nervous1.51695955
50MP0003718_maternal_effect1.51179770
51MP0008057_abnormal_DNA_replication1.48157017
52MP0000653_abnormal_sex_gland1.46609432
53MP0005645_abnormal_hypothalamus_physiol1.43424477
54MP0003195_calcinosis1.36596316
55MP0002102_abnormal_ear_morphology1.33577037
56MP0003183_abnormal_peptide_metabolism1.30942906
57MP0005395_other_phenotype1.28483419
58MP0008569_lethality_at_weaning1.25443406
59MP0002184_abnormal_innervation1.25168245
60MP0000955_abnormal_spinal_cord1.23328225
61MP0003879_abnormal_hair_cell1.23100921
62MP0003656_abnormal_erythrocyte_physiolo1.23031148
63MP0002168_other_aberrant_phenotype1.21604438
64MP0002882_abnormal_neuron_morphology1.18580175
65MP0001970_abnormal_pain_threshold1.17782542
66MP0004133_heterotaxia1.17401356
67MP0004742_abnormal_vestibular_system1.17215830
68MP0009780_abnormal_chondrocyte_physiolo1.16945109
69MP0002733_abnormal_thermal_nociception1.16283869
70MP0005248_abnormal_Harderian_gland1.13675204
71MP0002822_catalepsy1.13351772
72MP0004924_abnormal_behavior1.13188890
73MP0005386_behavior/neurological_phenoty1.13188890
74MP0002249_abnormal_larynx_morphology1.12641990
75MP0001529_abnormal_vocalization1.12087904
76MP0004811_abnormal_neuron_physiology1.10128221
77MP0002152_abnormal_brain_morphology1.07110077
78MP0004142_abnormal_muscle_tone1.04748725
79MP0006072_abnormal_retinal_apoptosis1.03422044
80MP0004215_abnormal_myocardial_fiber1.02680605
81MP0005499_abnormal_olfactory_system1.00749267
82MP0005394_taste/olfaction_phenotype1.00749267
83MP0003136_yellow_coat_color1.00706487
84MP0003634_abnormal_glial_cell0.98978923
85MP0002229_neurodegeneration0.97456791
86MP0000631_abnormal_neuroendocrine_gland0.97244404
87MP0002066_abnormal_motor_capabilities/c0.96846528
88MP0005253_abnormal_eye_physiology0.96584536
89MP0001963_abnormal_hearing_physiology0.96235560
90MP0003329_amyloid_beta_deposits0.96206395
91MP0002752_abnormal_somatic_nervous0.95875685
92MP0001905_abnormal_dopamine_level0.94027761
93MP0005409_darkened_coat_color0.93762166
94MP0001502_abnormal_circadian_rhythm0.93586260
95MP0002282_abnormal_trachea_morphology0.92736029
96MP0003122_maternal_imprinting0.91958332
97MP0002233_abnormal_nose_morphology0.91870627
98MP0003633_abnormal_nervous_system0.91370988
99MP0000427_abnormal_hair_cycle0.90114172
100MP0004019_abnormal_vitamin_homeostasis0.87953563
101MP0005389_reproductive_system_phenotype0.87939881
102MP0005391_vision/eye_phenotype0.87084258
103MP0001188_hyperpigmentation0.85709428
104MP0001485_abnormal_pinna_reflex0.85279176
105MP0000026_abnormal_inner_ear0.84015129
106MP0002009_preneoplasia0.83922845
107MP0004885_abnormal_endolymph0.81522871
108MP0008995_early_reproductive_senescence0.80517195
109MP0003937_abnormal_limbs/digits/tail_de0.79362749
110MP0003690_abnormal_glial_cell0.79341786
111MP0003631_nervous_system_phenotype0.78237273
112MP0000751_myopathy0.78152845
113MP0003861_abnormal_nervous_system0.78014909
114MP0001986_abnormal_taste_sensitivity0.76693740
115MP0004084_abnormal_cardiac_muscle0.75171758
116MP0002108_abnormal_muscle_morphology0.74454913
117MP0004134_abnormal_chest_morphology0.73037660
118MP0002638_abnormal_pupillary_reflex0.71984998
119MP0004233_abnormal_muscle_weight0.71978531
120MP0005171_absent_coat_pigmentation0.71947127
121MP0004145_abnormal_muscle_electrophysio0.71571453
122MP0003950_abnormal_plasma_membrane0.71164387
123MP0001765_abnormal_ion_homeostasis0.71151395
124MP0000569_abnormal_digit_pigmentation0.70775131
125MP0005195_abnormal_posterior_eye0.69753890
126MP0000920_abnormal_myelination0.69436236
127MP0001664_abnormal_digestion0.69172134
128MP0001177_atelectasis0.68188477
129MP0002234_abnormal_pharynx_morphology0.68154982
130MP0004883_abnormal_blood_vessel0.67953570
131MP0005377_hearing/vestibular/ear_phenot0.67570969
132MP0003878_abnormal_ear_physiology0.67570969
133MP0004858_abnormal_nervous_system0.67544172
134MP0004484_altered_response_of0.62742094
135MP0004036_abnormal_muscle_relaxation0.62495751
136MP0003938_abnormal_ear_development0.59480640
137MP0008961_abnormal_basal_metabolism0.59440404
138MP0002837_dystrophic_cardiac_calcinosis0.58668163
139MP0000049_abnormal_middle_ear0.58109875
140MP0002133_abnormal_respiratory_system0.58083976
141MP0005388_respiratory_system_phenotype0.58083976
142MP0002876_abnormal_thyroid_physiology0.57575956
143MP0001270_distended_abdomen0.57139391
144MP0003943_abnormal_hepatobiliary_system0.57079126
145MP0001286_abnormal_eye_development0.55651423

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal respiratory motile cilium physiology (HP:0012261)9.44175452
2* Absent/shortened dynein arms (HP:0200106)8.95284394
3* Dynein arm defect of respiratory motile cilia (HP:0012255)8.95284394
4Rhinitis (HP:0012384)8.36947368
5* Abnormal ciliary motility (HP:0012262)8.22241820
6* Abnormal respiratory epithelium morphology (HP:0012253)7.67948638
7* Abnormal respiratory motile cilium morphology (HP:0005938)7.67948638
8Chronic bronchitis (HP:0004469)6.36724844
9Nasal polyposis (HP:0100582)4.35627008
10Nephronophthisis (HP:0000090)4.35063686
11* Bronchiectasis (HP:0002110)4.25968791
12* Infertility (HP:0000789)4.11272554
13Medial flaring of the eyebrow (HP:0010747)3.66756707
14Abnormality of the nasal mucosa (HP:0000433)3.46806573
15Abnormality of the renal medulla (HP:0100957)3.43213635
16Abnormality of midbrain morphology (HP:0002418)3.33439392
17Molar tooth sign on MRI (HP:0002419)3.33439392
18Bronchitis (HP:0012387)3.30813070
19Tubulointerstitial nephritis (HP:0001970)3.29462379
20Gait imbalance (HP:0002141)3.24822412
21Pancreatic fibrosis (HP:0100732)3.17047702
22Abnormality of the lower motor neuron (HP:0002366)3.13215519
23Congenital primary aphakia (HP:0007707)3.09522867
24Focal motor seizures (HP:0011153)2.95419216
25Chronic otitis media (HP:0000389)2.81762343
26Nephrogenic diabetes insipidus (HP:0009806)2.81591599
27True hermaphroditism (HP:0010459)2.81312436
28Recurrent sinusitis (HP:0011108)2.76591813
29Fibular hypoplasia (HP:0003038)2.70440633
30Postaxial foot polydactyly (HP:0001830)2.57492083
31Median cleft lip (HP:0000161)2.56770174
32Recurrent otitis media (HP:0000403)2.54788862
33Genital tract atresia (HP:0001827)2.49714792
34Gaze-evoked nystagmus (HP:0000640)2.44362430
35Congenital hepatic fibrosis (HP:0002612)2.43009170
36Vaginal atresia (HP:0000148)2.42062021
37Poor coordination (HP:0002370)2.37261514
38Amyotrophic lateral sclerosis (HP:0007354)2.32622169
39Epileptic encephalopathy (HP:0200134)2.30067520
40Postaxial hand polydactyly (HP:0001162)2.27013687
41Focal seizures (HP:0007359)2.24357772
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21805064
43Hyperactive renin-angiotensin system (HP:0000841)2.21343203
44Occipital encephalocele (HP:0002085)2.19906408
45Abnormality of dentin (HP:0010299)2.19273888
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.18644350
47Recurrent bronchitis (HP:0002837)2.18471727
48Oculomotor apraxia (HP:0000657)2.16793599
49Progressive cerebellar ataxia (HP:0002073)2.16289742
50Chronic hepatic failure (HP:0100626)2.15700666
51Atonic seizures (HP:0010819)2.15422777
52Abnormality of the dental root (HP:0006486)2.10700410
53Taurodontia (HP:0000679)2.10700410
54Abnormality of permanent molar morphology (HP:0011071)2.10700410
55Pancreatic cysts (HP:0001737)2.09388098
56Tubulointerstitial abnormality (HP:0001969)2.08633714
57Cystic liver disease (HP:0006706)2.08563047
58Stage 5 chronic kidney disease (HP:0003774)2.07370310
59Hyperkalemia (HP:0002153)2.05140225
60Abnormality of molar (HP:0011077)2.00051067
61Abnormality of molar morphology (HP:0011070)2.00051067
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3022612
63Aplasia/Hypoplasia of the lens (HP:0008063)1.99321974
64Tubular atrophy (HP:0000092)1.94999629
65Abnormality of the dental pulp (HP:0006479)1.92952483
66Furrowed tongue (HP:0000221)1.90014833
67Gonadotropin excess (HP:0000837)1.86655661
68Febrile seizures (HP:0002373)1.82978105
69Myokymia (HP:0002411)1.81242258
70Facial cleft (HP:0002006)1.80599609
71Hyperventilation (HP:0002883)1.79927114
72Specific learning disability (HP:0001328)1.78778348
73Retinal dysplasia (HP:0007973)1.77714688
74Aplasia/Hypoplasia of the fibula (HP:0006492)1.76351728
75Abnormality of ocular smooth pursuit (HP:0000617)1.74655321
76Hemiparesis (HP:0001269)1.71332704
77Decreased circulating renin level (HP:0003351)1.70546284
78Bell-shaped thorax (HP:0001591)1.67328574
79Abnormal rod and cone electroretinograms (HP:0008323)1.66945519
80Decreased central vision (HP:0007663)1.66912355
81Dyschromatopsia (HP:0007641)1.62852133
82Male infertility (HP:0003251)1.62131892
83Microglossia (HP:0000171)1.60187069
84Widely spaced teeth (HP:0000687)1.58459061
85Short ribs (HP:0000773)1.58054231
86Preaxial hand polydactyly (HP:0001177)1.57635909
87Asplenia (HP:0001746)1.55813299
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.52436041
89Anencephaly (HP:0002323)1.52384382
90Absence seizures (HP:0002121)1.51719699
91Visual hallucinations (HP:0002367)1.50569730
92Impaired proprioception (HP:0010831)1.50183231
93Sclerocornea (HP:0000647)1.49986665
94Renal dysplasia (HP:0000110)1.49044115
95Central scotoma (HP:0000603)1.47893404
96Atelectasis (HP:0100750)1.47859043
97Cone-rod dystrophy (HP:0000548)1.47136462
98Bile duct proliferation (HP:0001408)1.45455974
99Abnormal biliary tract physiology (HP:0012439)1.45455974
100Abnormality of the renal cortex (HP:0011035)1.44847225
101Male pseudohermaphroditism (HP:0000037)1.44723159
102Abnormal drinking behavior (HP:0030082)1.44430780
103Polydipsia (HP:0001959)1.44430780
104* Chronic sinusitis (HP:0011109)1.43509462
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42388203
106Absent frontal sinuses (HP:0002688)1.40081797
107Dialeptic seizures (HP:0011146)1.40036510
108Fetal akinesia sequence (HP:0001989)1.40031572
109Nephropathy (HP:0000112)1.39799022
110Large eyes (HP:0001090)1.39604246
111J-shaped sella turcica (HP:0002680)1.39256913
112Abnormality of saccadic eye movements (HP:0000570)1.38130420
113Broad-based gait (HP:0002136)1.37869124
114Supranuclear gaze palsy (HP:0000605)1.37791711
115Abnormality of macular pigmentation (HP:0008002)1.37632192
116Ventricular fibrillation (HP:0001663)1.37056435
117Narrow forehead (HP:0000341)1.36446166
118Bony spicule pigmentary retinopathy (HP:0007737)1.33644943
119Popliteal pterygium (HP:0009756)1.32949406
120Prominent nasal bridge (HP:0000426)1.28221366
121Hyperaldosteronism (HP:0000859)1.25993075
122Highly arched eyebrow (HP:0002553)1.24621773
123Hypokalemic alkalosis (HP:0001949)1.23029831
124Tubulointerstitial fibrosis (HP:0005576)1.22694180
125Retinitis pigmentosa (HP:0000510)1.22686800
126Renal salt wasting (HP:0000127)1.18895750
127Broad foot (HP:0001769)1.17853987
128Multicystic kidney dysplasia (HP:0000003)1.14923595
129Abnormality of the frontal sinuses (HP:0002687)1.13509942
130Aganglionic megacolon (HP:0002251)1.13263934
131Abnormality of renin-angiotensin system (HP:0000847)1.11941327
132Left ventricular hypertrophy (HP:0001712)1.09787961
133Short thorax (HP:0010306)1.08791456
134Septo-optic dysplasia (HP:0100842)1.08711042
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.08524221
136Hip dysplasia (HP:0001385)1.08339061
137Absent speech (HP:0001344)1.06973983
138Anophthalmia (HP:0000528)1.05398446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.16082854
2PDK46.16082854
3PNCK4.53327562
4PDK23.84433133
5FRK3.51200621
6CASK2.71646582
7MAPK152.63990164
8OBSCN2.40965142
9EPHA42.34133778
10NTRK32.29776750
11STK392.25863287
12PTK2B2.15722967
13MAP2K72.10770031
14MAP3K42.06682210
15PRKD32.03990398
16MARK11.92132073
17NTRK21.87856238
18WNK41.87427860
19TNIK1.80630855
20MST41.80369889
21TSSK61.74380908
22ICK1.65817730
23INSRR1.63342644
24MAP3K71.37873694
25ACVR1B1.37223829
26CAMKK21.34021754
27DAPK21.33825861
28MINK11.32161920
29BRSK21.31022172
30MAPK131.26167476
31TESK11.23656368
32PLK21.23342850
33MAP3K121.21743592
34STK241.21121809
35TAOK31.16945540
36WNK11.12526804
37MAP2K41.11583140
38FGFR21.07275150
39OXSR11.06527988
40WEE11.06198115
41PAK61.00828078
42NEK61.00615300
43FGFR30.97196977
44STK380.95646089
45MAPKAPK30.94865586
46TYRO30.94597830
47MAP3K130.93223251
48NLK0.93066767
49PRKCG0.92774280
50BRD40.90180438
51GRK50.89494616
52CCNB10.87801628
53CSK0.86483162
54NEK90.85649888
55CAMK1G0.85367287
56TRPM70.83130873
57LMTK20.82135335
58CAMK2A0.81001819
59TTK0.80184592
60SIK20.79964575
61CAMK2B0.78303080
62CDK50.78036799
63TEC0.74149179
64CDK30.74124592
65ARAF0.73932283
66PLK40.73722217
67RIPK40.72034310
68CDK190.71753309
69MAP3K90.71640359
70CDK120.71228262
71GRK70.70646779
72LATS10.69114572
73PASK0.68824404
74SGK4940.68581724
75SGK2230.68581724
76IRAK10.66784633
77AKT30.65592383
78NME10.65123550
79MUSK0.64225303
80PHKG10.63553798
81PHKG20.63553798
82SGK20.61990270
83PAK30.60763693
84TYK20.58297272
85MAP3K60.57716173
86DAPK10.57652580
87WNK30.57428219
88DYRK1A0.56396496
89EPHA30.55806491
90UHMK10.55586922
91PRKCQ0.55166917
92STK38L0.55011293
93PRKAA20.54000801
94TGFBR10.52382934
95PIK3CG0.52057154
96PRPF4B0.51986191
97PDK10.51591518
98MARK20.50810335
99ERBB30.49893467
100ERBB20.49819826
101ADRBK20.49779631
102MAPKAPK50.49708305
103CAMK2D0.49677323
104PRKCE0.49179679
105CAMKK10.47899173
106KSR10.46627943
107MKNK20.46302919
108BMPR1B0.45357389
109IRAK20.45148877
110PINK10.45114625
111BMPR20.43156423
112FES0.43149499
113STK110.43104271
114PKN10.42377184
115GRK10.42356905
116PRKG10.41580155
117BCR0.41499252
118KSR20.40776913
119CAMK2G0.40070432
120CSNK1G20.39215850
121CAMK10.39086395
122CDK180.38648648
123DYRK30.38567788
124DMPK0.38519958
125VRK10.38354275
126MAP3K20.38318980
127RAF10.37940541
128RPS6KB10.37712066
129CDK150.37355903
130MAPK120.35822017
131SGK10.35156883
132CDK140.34832427
133DYRK1B0.34779146
134MAP4K20.34774205
135BRAF0.33164686
136ADRBK10.32414015
137NTRK10.31786710
138YES10.31781762
139PRKCZ0.31604910
140LRRK20.30737770
141ABL10.30650536
142IKBKE0.30592314
143MELK0.30454983
144RPS6KA20.30113825
145MAPK100.29082475
146PRKACA0.28994720
147RPS6KA30.28665902
148CDK11A0.28612869
149ROCK20.28130667
150SGK30.28126475
151PRKACB0.28021061
152CDK90.26469685
153PLK10.26236158
154TNK20.26235123
155TAF10.24648626

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82142205
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.43770065
3Chemical carcinogenesis_Homo sapiens_hsa052042.97208501
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.92212916
5Synaptic vesicle cycle_Homo sapiens_hsa047212.73875335
6Histidine metabolism_Homo sapiens_hsa003402.67236157
7Olfactory transduction_Homo sapiens_hsa047402.64416936
8Amphetamine addiction_Homo sapiens_hsa050312.57453201
9Circadian entrainment_Homo sapiens_hsa047132.46264144
10Glutamatergic synapse_Homo sapiens_hsa047242.46053049
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43464075
12Morphine addiction_Homo sapiens_hsa050322.41614149
13GABAergic synapse_Homo sapiens_hsa047272.32634611
14ABC transporters_Homo sapiens_hsa020102.23408481
15Taste transduction_Homo sapiens_hsa047422.19094800
16Long-term potentiation_Homo sapiens_hsa047202.18233614
17Renin secretion_Homo sapiens_hsa049242.09447487
18Phenylalanine metabolism_Homo sapiens_hsa003601.96248073
19Caffeine metabolism_Homo sapiens_hsa002321.95639252
20Huntingtons disease_Homo sapiens_hsa050161.92538629
21Vitamin B6 metabolism_Homo sapiens_hsa007501.90209760
22Collecting duct acid secretion_Homo sapiens_hsa049661.88050761
23Dorso-ventral axis formation_Homo sapiens_hsa043201.87896750
24Salivary secretion_Homo sapiens_hsa049701.87019277
25Insulin secretion_Homo sapiens_hsa049111.80709434
26Phototransduction_Homo sapiens_hsa047441.79776841
27Dopaminergic synapse_Homo sapiens_hsa047281.78374792
28Calcium signaling pathway_Homo sapiens_hsa040201.76091506
29beta-Alanine metabolism_Homo sapiens_hsa004101.75548707
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69471200
31Retinol metabolism_Homo sapiens_hsa008301.68004133
32Serotonergic synapse_Homo sapiens_hsa047261.63947020
33Tyrosine metabolism_Homo sapiens_hsa003501.62932674
34Pyruvate metabolism_Homo sapiens_hsa006201.62055020
35Gastric acid secretion_Homo sapiens_hsa049711.58333274
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49545585
37Cardiac muscle contraction_Homo sapiens_hsa042601.47187612
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44000389
39Cocaine addiction_Homo sapiens_hsa050301.41767641
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36210311
41Glucagon signaling pathway_Homo sapiens_hsa049221.36144742
42Oxytocin signaling pathway_Homo sapiens_hsa049211.30741304
43Cholinergic synapse_Homo sapiens_hsa047251.24804707
44Oocyte meiosis_Homo sapiens_hsa041141.24476625
45Long-term depression_Homo sapiens_hsa047301.24453880
46Axon guidance_Homo sapiens_hsa043601.21709584
47cAMP signaling pathway_Homo sapiens_hsa040241.20212581
48Selenocompound metabolism_Homo sapiens_hsa004501.17549279
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16600714
50Fatty acid biosynthesis_Homo sapiens_hsa000611.16127751
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15131482
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11931849
53Estrogen signaling pathway_Homo sapiens_hsa049151.10769027
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08631580
55Basal transcription factors_Homo sapiens_hsa030221.05806412
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00822084
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.00780010
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00724639
59Oxidative phosphorylation_Homo sapiens_hsa001901.00656487
60Notch signaling pathway_Homo sapiens_hsa043301.00098695
61Ether lipid metabolism_Homo sapiens_hsa005650.98684158
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.96591246
63Alzheimers disease_Homo sapiens_hsa050100.96450915
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95956428
65Nitrogen metabolism_Homo sapiens_hsa009100.94322976
66Tight junction_Homo sapiens_hsa045300.94181069
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90376967
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89972775
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88671131
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87107967
71Starch and sucrose metabolism_Homo sapiens_hsa005000.86338289
72Peroxisome_Homo sapiens_hsa041460.85914543
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83916765
74Gap junction_Homo sapiens_hsa045400.80433219
75GnRH signaling pathway_Homo sapiens_hsa049120.80224788
76Mineral absorption_Homo sapiens_hsa049780.79801549
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79344260
78Vibrio cholerae infection_Homo sapiens_hsa051100.79094948
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.77917549
80Glutathione metabolism_Homo sapiens_hsa004800.74384348
81Melanogenesis_Homo sapiens_hsa049160.73809578
82Pancreatic secretion_Homo sapiens_hsa049720.71716165
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71356443
84Fanconi anemia pathway_Homo sapiens_hsa034600.70991972
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70895125
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.70816550
87Glycerolipid metabolism_Homo sapiens_hsa005610.70682744
88Wnt signaling pathway_Homo sapiens_hsa043100.70447206
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69258071
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69187294
91Basal cell carcinoma_Homo sapiens_hsa052170.69060271
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.68992424
93Thyroid hormone synthesis_Homo sapiens_hsa049180.67882343
94Propanoate metabolism_Homo sapiens_hsa006400.64769964
95Butanoate metabolism_Homo sapiens_hsa006500.64581152
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.64289583
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63660548
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63635066
99Inositol phosphate metabolism_Homo sapiens_hsa005620.63549085
100Type II diabetes mellitus_Homo sapiens_hsa049300.62454628
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61740436
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60852545
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60761920
104Parkinsons disease_Homo sapiens_hsa050120.60324084
105MAPK signaling pathway_Homo sapiens_hsa040100.60088198
106Arachidonic acid metabolism_Homo sapiens_hsa005900.60061086
107Linoleic acid metabolism_Homo sapiens_hsa005910.58913985
108FoxO signaling pathway_Homo sapiens_hsa040680.57728875
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56800958
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56408949
111Ovarian steroidogenesis_Homo sapiens_hsa049130.56364282
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55554314
113Adherens junction_Homo sapiens_hsa045200.54132175
114ErbB signaling pathway_Homo sapiens_hsa040120.52384100
115Hedgehog signaling pathway_Homo sapiens_hsa043400.51830821
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50952525
117TGF-beta signaling pathway_Homo sapiens_hsa043500.49189489
118Ras signaling pathway_Homo sapiens_hsa040140.48683147
119Alcoholism_Homo sapiens_hsa050340.48387131
120Insulin resistance_Homo sapiens_hsa049310.46891523
121Prostate cancer_Homo sapiens_hsa052150.46531631
122Endometrial cancer_Homo sapiens_hsa052130.46415933
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45640860
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45544875
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.44416973
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44324982
127Choline metabolism in cancer_Homo sapiens_hsa052310.44164776
128Fatty acid degradation_Homo sapiens_hsa000710.44136213
129Circadian rhythm_Homo sapiens_hsa047100.43904829
130Sphingolipid metabolism_Homo sapiens_hsa006000.42924834
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42746637
132Regulation of autophagy_Homo sapiens_hsa041400.42258485
133Hematopoietic cell lineage_Homo sapiens_hsa046400.41425553
134Antigen processing and presentation_Homo sapiens_hsa046120.41424997
135Rheumatoid arthritis_Homo sapiens_hsa053230.39960471
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.39595756
137Dilated cardiomyopathy_Homo sapiens_hsa054140.36923734
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36426466
139B cell receptor signaling pathway_Homo sapiens_hsa046620.35976600
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31786593
141Purine metabolism_Homo sapiens_hsa002300.27621824
142Rap1 signaling pathway_Homo sapiens_hsa040150.26548075
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25833290
144African trypanosomiasis_Homo sapiens_hsa051430.22945204

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