CCDC40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is necessary for motile cilia function. It functions in correct left-right axis formation by regulating the assembly of the inner dynein arm and the dynein regulatory complexes, which control ciliary beat. Mutations in this gene cause ciliary dyskinesia type 15, a disorder due to defects in cilia motility. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.19566187
2proline biosynthetic process (GO:0006561)7.30726830
3left/right pattern formation (GO:0060972)6.95510010
4* axonemal dynein complex assembly (GO:0070286)6.68842940
5DNA deamination (GO:0045006)6.48327801
6* cilium movement (GO:0003341)6.03008018
7* epithelial cilium movement (GO:0003351)6.01941638
8cilium organization (GO:0044782)5.87846497
9cilium assembly (GO:0042384)5.76414937
10fusion of sperm to egg plasma membrane (GO:0007342)5.75886929
11microtubule bundle formation (GO:0001578)5.71954270
12left/right axis specification (GO:0070986)5.67439267
13motile cilium assembly (GO:0044458)5.66626035
14transcription from mitochondrial promoter (GO:0006390)5.58979136
15piRNA metabolic process (GO:0034587)5.38671342
16replication fork processing (GO:0031297)5.37427425
17proline metabolic process (GO:0006560)5.34509149
18sperm-egg recognition (GO:0035036)5.13889187
19sperm motility (GO:0030317)5.13148265
20establishment of apical/basal cell polarity (GO:0035089)5.09361650
21binding of sperm to zona pellucida (GO:0007339)4.82700585
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.66266285
23cilium morphogenesis (GO:0060271)4.64523713
24protein localization to cilium (GO:0061512)4.64298453
25* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.61828042
26embryonic process involved in female pregnancy (GO:0060136)4.60084891
27cellular component assembly involved in morphogenesis (GO:0010927)4.58797009
28multicellular organism reproduction (GO:0032504)4.57784515
29establishment or maintenance of monopolar cell polarity (GO:0061339)4.55213418
30establishment of monopolar cell polarity (GO:0061162)4.55213418
31positive regulation of protein homooligomerization (GO:0032464)4.55020169
32cell-cell recognition (GO:0009988)4.48056024
33male meiosis (GO:0007140)4.42415912
34synaptonemal complex organization (GO:0070193)4.40993061
35spermatid development (GO:0007286)4.32334840
36acrosome assembly (GO:0001675)4.31436315
37vitamin transmembrane transport (GO:0035461)4.22375167
38plasma membrane fusion (GO:0045026)4.17225494
39oxidative demethylation (GO:0070989)4.13244641
40mitochondrial DNA metabolic process (GO:0032042)4.08751674
41axoneme assembly (GO:0035082)4.07548774
42primary alcohol catabolic process (GO:0034310)4.06629735
43acrosome reaction (GO:0007340)4.06219569
44synaptonemal complex assembly (GO:0007130)4.05623139
45somatic hypermutation of immunoglobulin genes (GO:0016446)4.04980436
46somatic diversification of immune receptors via somatic mutation (GO:0002566)4.04980436
47* microtubule-based movement (GO:0007018)4.03250699
48* regulation of microtubule-based movement (GO:0060632)4.02754163
49mRNA cleavage (GO:0006379)3.98002609
50viral mRNA export from host cell nucleus (GO:0046784)3.92154672
51centriole assembly (GO:0098534)3.92037382
52poly(A)+ mRNA export from nucleus (GO:0016973)3.91076697
53cell projection assembly (GO:0030031)3.90459697
54cell wall macromolecule catabolic process (GO:0016998)3.88593628
55cell wall macromolecule metabolic process (GO:0044036)3.88593628
56lung epithelium development (GO:0060428)3.82836398
57DNA strand renaturation (GO:0000733)3.81682456
58regulation of protein homooligomerization (GO:0032462)3.80051915
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.75963563
60telomere maintenance via semi-conservative replication (GO:0032201)3.71056793
61formation of translation preinitiation complex (GO:0001731)3.67034492
62microtubule depolymerization (GO:0007019)3.64022224
63nonmotile primary cilium assembly (GO:0035058)3.63540748
64negative regulation of cell cycle arrest (GO:0071157)3.63477680
65reproduction (GO:0000003)3.63429743
66protein polyglutamylation (GO:0018095)3.62983586
67regulation of integrin activation (GO:0033623)3.59240165
68photoreceptor cell maintenance (GO:0045494)3.57023656
69termination of RNA polymerase II transcription (GO:0006369)3.55788729
70intraciliary transport (GO:0042073)3.54888577
71smoothened signaling pathway (GO:0007224)3.53707377
72* regulation of cilium movement (GO:0003352)3.50730769
73base-excision repair (GO:0006284)3.49284329
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.48739523
75diterpenoid biosynthetic process (GO:0016102)3.48629558
76regulation of RNA export from nucleus (GO:0046831)3.47671079
77spliceosomal tri-snRNP complex assembly (GO:0000244)3.46652819
78ventricular system development (GO:0021591)3.43806797
79DNA double-strand break processing (GO:0000729)3.42542260
80embryonic camera-type eye development (GO:0031076)3.38917530
81exogenous drug catabolic process (GO:0042738)3.38151690
82ethanol metabolic process (GO:0006067)3.37493791
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34986922
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34986922
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.34986922
86negative regulation of T cell differentiation in thymus (GO:0033085)3.31634690
87meiotic chromosome segregation (GO:0045132)3.30629728
88DNA methylation involved in gamete generation (GO:0043046)3.29646162
89meiotic nuclear division (GO:0007126)3.27927777
90DNA strand elongation involved in DNA replication (GO:0006271)3.26715979
91glycerol ether metabolic process (GO:0006662)3.26316066
92fertilization (GO:0009566)3.24333499
93regulation of spindle checkpoint (GO:0090231)3.22314983
94regulation of protein polyubiquitination (GO:1902914)3.21770618
95single strand break repair (GO:0000012)3.21380219
96microtubule polymerization or depolymerization (GO:0031109)3.21105691
97single fertilization (GO:0007338)3.20306279
98negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19590567
99lateral sprouting from an epithelium (GO:0060601)3.18973629
100double-strand break repair via nonhomologous end joining (GO:0006303)3.18297618
101non-recombinational repair (GO:0000726)3.18297618
102* determination of left/right symmetry (GO:0007368)3.17886156
103response to xenobiotic stimulus (GO:0009410)3.16779258
104establishment of tissue polarity (GO:0007164)3.16326999
105establishment of planar polarity (GO:0001736)3.16326999
106negative regulation of JAK-STAT cascade (GO:0046426)3.15255195
107telomere maintenance via recombination (GO:0000722)3.11180223
108centriole replication (GO:0007099)3.10451107
109male meiosis I (GO:0007141)3.10269893
110maturation of 5.8S rRNA (GO:0000460)3.08690757
111cellular response to ATP (GO:0071318)3.08099387
112one-carbon compound transport (GO:0019755)3.08091366
113DNA strand elongation (GO:0022616)3.07966342
114mitotic G1 DNA damage checkpoint (GO:0031571)3.07250438
115lateral ventricle development (GO:0021670)3.06993330
116regulation of translational fidelity (GO:0006450)3.06951217
117spermatogenesis (GO:0007283)3.05438960
118male gamete generation (GO:0048232)3.04818243
119cornea development in camera-type eye (GO:0061303)3.03797958
120cytoplasmic microtubule organization (GO:0031122)3.02711911
121DNA ligation (GO:0006266)3.01238713
122* determination of bilateral symmetry (GO:0009855)3.00922618
123meiotic cell cycle (GO:0051321)3.00817985
124pyrimidine-containing compound transmembrane transport (GO:0072531)2.99318782
125negative regulation of immunoglobulin mediated immune response (GO:0002890)2.99205544
126negative regulation of B cell mediated immunity (GO:0002713)2.99205544
127regulation of podosome assembly (GO:0071801)2.98969237
128drug catabolic process (GO:0042737)2.98101267
129ether metabolic process (GO:0018904)2.97469587
130terpenoid biosynthetic process (GO:0016114)2.95539053
131regulation of double-strand break repair (GO:2000779)2.95381989
132retinoic acid metabolic process (GO:0042573)2.93742366
133sperm capacitation (GO:0048240)2.92855399
134mRNA polyadenylation (GO:0006378)2.92398267
135* specification of symmetry (GO:0009799)2.92306310
136base-excision repair, AP site formation (GO:0006285)2.91847155
137histone H4-K12 acetylation (GO:0043983)2.90914808
138retinal cone cell development (GO:0046549)2.89013743
139germ cell development (GO:0007281)2.87290832
140mitochondrial RNA metabolic process (GO:0000959)2.87146436
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.85326354
142nucleoside diphosphate phosphorylation (GO:0006165)2.85044112
143chromosome organization involved in meiosis (GO:0070192)2.84626188
144DNA integration (GO:0015074)2.84496563
145gamete generation (GO:0007276)2.84443308
146regulation of collateral sprouting (GO:0048670)2.83832591
147glomerular epithelial cell development (GO:0072310)2.82791180
148limb development (GO:0060173)2.80733701
149appendage development (GO:0048736)2.80733701
150positive regulation of smoothened signaling pathway (GO:0045880)2.77010152
151neural tube formation (GO:0001841)2.69355118
152microtubule severing (GO:0051013)2.60867028
153pyrimidine nucleobase catabolic process (GO:0006208)2.60591717
154aldehyde catabolic process (GO:0046185)2.57848169
155* microtubule-based process (GO:0007017)2.56635160
156organelle assembly (GO:0070925)2.55222673
157regulation of interleukin-5 production (GO:0032674)2.54916182
158retinal rod cell development (GO:0046548)2.54376275
159response to pheromone (GO:0019236)2.54225271
160apical protein localization (GO:0045176)2.53089639
161regulation of cilium assembly (GO:1902017)2.53024958
162auditory behavior (GO:0031223)2.52157362
163spinal cord motor neuron differentiation (GO:0021522)2.47158710
164negative regulation of humoral immune response (GO:0002921)2.46813659
165ethanol oxidation (GO:0006069)2.41283339
166regulation of smoothened signaling pathway (GO:0008589)2.39598068
167behavioral response to nicotine (GO:0035095)2.39401774
168head development (GO:0060322)2.37604392
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36488324
170neurotransmitter metabolic process (GO:0042133)2.33864417
171tolerance induction (GO:0002507)2.31796172
172substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.26953527
173substrate-independent telencephalic tangential migration (GO:0021826)2.26953527
174transmission of nerve impulse (GO:0019226)2.24654396
175brain morphogenesis (GO:0048854)2.23838115
176vocalization behavior (GO:0071625)2.19752676
177regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.19479026
178negative regulation of inclusion body assembly (GO:0090084)2.18974384
179intra-S DNA damage checkpoint (GO:0031573)2.18770913
180dorsal/ventral pattern formation (GO:0009953)2.17389615
181regulation of germinal center formation (GO:0002634)2.17043221
182neurotransmitter biosynthetic process (GO:0042136)2.16141916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.67770130
2E2F7_22180533_ChIP-Seq_HELA_Human3.22901964
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.00857611
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.96055906
5VDR_22108803_ChIP-Seq_LS180_Human2.92574101
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87780173
7EZH2_22144423_ChIP-Seq_EOC_Human2.85696838
8DROSHA_22980978_ChIP-Seq_HELA_Human2.72940319
9ZNF274_21170338_ChIP-Seq_K562_Hela2.62896320
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43380225
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41903686
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40798276
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39439586
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30781664
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27833552
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.17701693
17* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.12554489
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09147305
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08464145
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07882890
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04878927
22PIAS1_25552417_ChIP-Seq_VCAP_Human2.03548353
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00709895
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92834461
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.91468255
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90032966
27GBX2_23144817_ChIP-Seq_PC3_Human1.89045723
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.84394781
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81904044
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81904044
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81904044
32VDR_21846776_ChIP-Seq_THP-1_Human1.80567772
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.76982814
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73773847
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73231959
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71745171
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70595614
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70182817
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68404266
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67706666
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67499206
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64223227
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63087239
44* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62893844
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62258102
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.61406979
47SMAD4_21799915_ChIP-Seq_A2780_Human1.61187955
48POU5F1_16518401_ChIP-PET_MESCs_Mouse1.60898843
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58752957
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.57556607
51FUS_26573619_Chip-Seq_HEK293_Human1.56348360
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.55978333
53SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55777464
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.55717346
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.54913825
56AHR_22903824_ChIP-Seq_MCF-7_Human1.54379715
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54331376
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53283100
59REST_21632747_ChIP-Seq_MESCs_Mouse1.52788194
60IGF1R_20145208_ChIP-Seq_DFB_Human1.52360209
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50654691
62* GABP_19822575_ChIP-Seq_HepG2_Human1.50436096
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49561883
64ER_23166858_ChIP-Seq_MCF-7_Human1.49413048
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47848101
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47791573
67ZNF263_19887448_ChIP-Seq_K562_Human1.47657691
68CBP_20019798_ChIP-Seq_JUKART_Human1.47374858
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47374858
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.47308955
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47178704
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46718864
73TAF15_26573619_Chip-Seq_HEK293_Human1.46409092
74STAT3_23295773_ChIP-Seq_U87_Human1.46357608
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45638294
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45365317
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45358015
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.43455824
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42921560
80XRN2_22483619_ChIP-Seq_HELA_Human1.42900941
81P300_19829295_ChIP-Seq_ESCs_Human1.42891199
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42591551
83AR_21572438_ChIP-Seq_LNCaP_Human1.42327977
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.42277334
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39948617
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39948617
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39419414
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38774567
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38405744
90TTF2_22483619_ChIP-Seq_HELA_Human1.38059398
91BCAT_22108803_ChIP-Seq_LS180_Human1.36736535
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36362971
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34874662
94* YY1_22570637_ChIP-Seq_MALME-3M_Human1.34837422
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34541703
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33833397
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33444617
98TCF4_22108803_ChIP-Seq_LS180_Human1.33085331
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32975758
100* TCF4_23295773_ChIP-Seq_U87_Human1.32193052
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31634560
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31592128
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31446560
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31230022
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30343386
106AR_25329375_ChIP-Seq_VCAP_Human1.30286086
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.28964646
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28546089
109RNF2_27304074_Chip-Seq_NSC_Mouse1.28268162
110DCP1A_22483619_ChIP-Seq_HELA_Human1.27312393
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.26957483
112RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26569953
113RUNX2_22187159_ChIP-Seq_PCA_Human1.26482946
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.25998958
115SPI1_26923725_Chip-Seq_HPCs_Mouse1.25613783
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24907355
117EWS_26573619_Chip-Seq_HEK293_Human1.23492398
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23186329
119NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21439611
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.21230125
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20770041
122MYC_22102868_ChIP-Seq_BL_Human1.20644619
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20518317
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20443374
125LXR_22292898_ChIP-Seq_THP-1_Human1.19985780
126PHF8_20622854_ChIP-Seq_HELA_Human1.19349993
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18492403
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18227719
129* RARB_24833708_ChIP-Seq_LIVER_Mouse1.18139853
130* RARA_24833708_ChIP-Seq_LIVER_Mouse1.17848114
131JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17815630
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17761665
133KDM5A_27292631_Chip-Seq_BREAST_Human1.17442119
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.17220901
135FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17093893
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16198494
137* STAT1_20625510_ChIP-Seq_HELA_Human1.15410203
138SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14978157
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14702753
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14269969
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13743951
142TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12889171
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12597619
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12474202
145VDR_23849224_ChIP-Seq_CD4+_Human1.12155834
146EED_16625203_ChIP-ChIP_MESCs_Mouse1.11469149
147E2F1_20622854_ChIP-Seq_HELA_Human1.11428677
148ETV1_20927104_ChIP-Seq_GIST48_Human1.11166409
149* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.09910724
150SMAD3_21741376_ChIP-Seq_ESCs_Human1.09839807
151BCOR_27268052_Chip-Seq_Bcells_Human1.09839657
152WDR5_24793694_ChIP-Seq_LNCAP_Human1.09536301
153KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08835446
154FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08226771
155EZH2_27304074_Chip-Seq_ESCs_Mouse1.08128186
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08009043
157RNF2_27304074_Chip-Seq_ESCs_Mouse1.07960796
158TP53_18474530_ChIP-ChIP_U2OS_Human1.07822400
159ESR1_20079471_ChIP-ChIP_T-47D_Human1.07168017
160ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06760932
161SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06050561
162E2F1_21310950_ChIP-Seq_MCF-7_Human1.05708088
163GABP_17652178_ChIP-ChIP_JURKAT_Human1.05438232
164FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05313416
165SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05286718
166CTCF_26484167_Chip-Seq_Bcells_Mouse1.04523933
167FOXP1_21924763_ChIP-Seq_HESCs_Human1.04318393
168ERA_21632823_ChIP-Seq_H3396_Human1.03953983
169TBL1_22424771_ChIP-Seq_293T_Human1.03945956
170UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03770712
171NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03020667
172GATA1_26923725_Chip-Seq_HPCs_Mouse1.02842857
173* ELF1_20517297_ChIP-Seq_JURKAT_Human1.02646338
174FOXA1_25329375_ChIP-Seq_VCAP_Human1.02640579
175FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02640579
176AR_19668381_ChIP-Seq_PC3_Human1.02526304
177PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02164503
178PRDM14_20953172_ChIP-Seq_ESCs_Human1.01572550
179NCOR_22424771_ChIP-Seq_293T_Human1.00639508
180ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00350791
181JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00348616
182ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99914095
183TP53_16413492_ChIP-PET_HCT116_Human0.99812239
184PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99687505
185* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98944380
186SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98869424
187SALL1_21062744_ChIP-ChIP_HESCs_Human0.98684746
188PHF8_20622853_ChIP-Seq_HELA_Human0.98350580
189NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98092011
190STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96916359
191SMAD4_21741376_ChIP-Seq_HESCs_Human0.96817093
192NFYA_21822215_ChIP-Seq_K562_Human0.96029564
193TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95752736
194SMAD3_21741376_ChIP-Seq_HESCs_Human0.94440855
195GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93901812
196GATA3_21878914_ChIP-Seq_MCF-7_Human0.93616952
197SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92783630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.91476195
2MP0008057_abnormal_DNA_replication5.64881810
3MP0002653_abnormal_ependyma_morphology3.98336025
4MP0008877_abnormal_DNA_methylation3.98193738
5MP0008875_abnormal_xenobiotic_pharmacok3.75425667
6MP0009278_abnormal_bone_marrow3.17536610
7MP0010094_abnormal_chromosome_stability3.06051790
8MP0004043_abnormal_pH_regulation3.02722244
9MP0010030_abnormal_orbit_morphology2.90687097
10MP0001929_abnormal_gametogenesis2.87702977
11MP0003698_abnormal_male_reproductive2.80818174
12MP0000566_synostosis2.76264821
13MP0008789_abnormal_olfactory_epithelium2.75856049
14MP0008058_abnormal_DNA_repair2.74777356
15MP0004233_abnormal_muscle_weight2.73480692
16MP0008995_early_reproductive_senescence2.64434056
17MP0005171_absent_coat_pigmentation2.60556497
18MP0002210_abnormal_sex_determination2.36176146
19MP0004133_heterotaxia2.31845431
20MP0009780_abnormal_chondrocyte_physiolo2.27453277
21MP0003111_abnormal_nucleus_morphology2.25589094
22MP0001545_abnormal_hematopoietic_system2.23101154
23MP0005397_hematopoietic_system_phenotyp2.23101154
24MP0003878_abnormal_ear_physiology2.22473305
25MP0005377_hearing/vestibular/ear_phenot2.22473305
26MP0003786_premature_aging2.16318611
27MP0001145_abnormal_male_reproductive2.14261847
28MP0005394_taste/olfaction_phenotype2.12899025
29MP0005499_abnormal_olfactory_system2.12899025
30MP0005174_abnormal_tail_pigmentation2.08555509
31MP0002282_abnormal_trachea_morphology2.05153876
32MP0004957_abnormal_blastocyst_morpholog2.03180537
33MP0002009_preneoplasia2.03054680
34MP0001293_anophthalmia2.02687252
35MP0003890_abnormal_embryonic-extraembry1.99888981
36MP0001485_abnormal_pinna_reflex1.99309707
37MP0002277_abnormal_respiratory_mucosa1.96968890
38MP0003693_abnormal_embryo_hatching1.92197993
39MP0005551_abnormal_eye_electrophysiolog1.80419495
40MP0002638_abnormal_pupillary_reflex1.79555753
41MP0000383_abnormal_hair_follicle1.78967267
42MP0008932_abnormal_embryonic_tissue1.78957663
43MP0003077_abnormal_cell_cycle1.77482454
44MP0002735_abnormal_chemical_nociception1.77030039
45MP0000653_abnormal_sex_gland1.76549290
46MP0002161_abnormal_fertility/fecundity1.74402045
47MP0006072_abnormal_retinal_apoptosis1.69558682
48MP0009046_muscle_twitch1.56703321
49MP0002084_abnormal_developmental_patter1.56396736
50MP0006276_abnormal_autonomic_nervous1.56102091
51MP0002909_abnormal_adrenal_gland1.54563598
52MP0002734_abnormal_mechanical_nocicepti1.54016740
53MP0002249_abnormal_larynx_morphology1.52048551
54MP0003880_abnormal_central_pattern1.49650490
55MP0003119_abnormal_digestive_system1.47462164
56MP0000778_abnormal_nervous_system1.45222738
57MP0005075_abnormal_melanosome_morpholog1.43790087
58MP0000015_abnormal_ear_pigmentation1.43719316
59MP0002102_abnormal_ear_morphology1.43539727
60MP0009745_abnormal_behavioral_response1.43531757
61MP0001697_abnormal_embryo_size1.39163883
62MP0001529_abnormal_vocalization1.39109871
63MP0002085_abnormal_embryonic_tissue1.38626577
64MP0001968_abnormal_touch/_nociception1.37786874
65MP0002557_abnormal_social/conspecific_i1.36306228
66MP0002233_abnormal_nose_morphology1.35105891
67MP0000631_abnormal_neuroendocrine_gland1.33862971
68MP0003283_abnormal_digestive_organ1.33297660
69MP0001486_abnormal_startle_reflex1.31090386
70MP0002876_abnormal_thyroid_physiology1.30013619
71MP0005646_abnormal_pituitary_gland1.29186302
72MP0003195_calcinosis1.28566478
73MP0001970_abnormal_pain_threshold1.28540241
74MP0000490_abnormal_crypts_of1.27908854
75MP0000026_abnormal_inner_ear1.25778771
76MP0004885_abnormal_endolymph1.24163529
77MP0002928_abnormal_bile_duct1.23740117
78MP0002086_abnormal_extraembryonic_tissu1.23273953
79MP0001730_embryonic_growth_arrest1.23148826
80MP0002272_abnormal_nervous_system1.22348142
81MP0002572_abnormal_emotion/affect_behav1.20659243
82MP0002168_other_aberrant_phenotype1.20411246
83MP0002234_abnormal_pharynx_morphology1.20240989
84MP0000955_abnormal_spinal_cord1.19921175
85MP0001502_abnormal_circadian_rhythm1.18046443
86MP0004197_abnormal_fetal_growth/weight/1.17715686
87MP0003937_abnormal_limbs/digits/tail_de1.16349211
88MP0008872_abnormal_physiological_respon1.15237077
89MP0005380_embryogenesis_phenotype1.15218603
90MP0001672_abnormal_embryogenesis/_devel1.15218603
91MP0010678_abnormal_skin_adnexa1.11381145
92MP0000350_abnormal_cell_proliferation1.11015267
93MP0006292_abnormal_olfactory_placode1.10909605
94MP0003122_maternal_imprinting1.09116090
95MP0005623_abnormal_meninges_morphology1.09084241
96MP0002736_abnormal_nociception_after1.07442001
97MP0000371_diluted_coat_color1.06641538
98MP0008007_abnormal_cellular_replicative1.06503681
99MP0005076_abnormal_cell_differentiation1.06268958
100MP0002752_abnormal_somatic_nervous1.04525144
101MP0010352_gastrointestinal_tract_polyps1.03047580
102MP0005195_abnormal_posterior_eye1.02557304
103MP0001963_abnormal_hearing_physiology1.02019336
104MP0004019_abnormal_vitamin_homeostasis1.00469562
105MP0003646_muscle_fatigue0.99210932
106MP0002080_prenatal_lethality0.99082978
107MP0003938_abnormal_ear_development0.98316096
108MP0004859_abnormal_synaptic_plasticity0.98294799
109MP0002882_abnormal_neuron_morphology0.97629859
110MP0001765_abnormal_ion_homeostasis0.96315759
111MP0002132_abnormal_respiratory_system0.95539904
112MP0002160_abnormal_reproductive_system0.95231585
113MP0005083_abnormal_biliary_tract0.94957964
114MP0000313_abnormal_cell_death0.94886820
115MP0002063_abnormal_learning/memory/cond0.94732338
116MP0002067_abnormal_sensory_capabilities0.92718010
117MP0003635_abnormal_synaptic_transmissio0.92694273
118MP0004742_abnormal_vestibular_system0.91950406
119MP0002822_catalepsy0.91367358
120MP0003011_delayed_dark_adaptation0.90791197
121MP0003984_embryonic_growth_retardation0.89807811
122MP0003787_abnormal_imprinting0.89234873
123MP0002019_abnormal_tumor_incidence0.88636842
124MP0001984_abnormal_olfaction0.87792619
125MP0003567_abnormal_fetal_cardiomyocyte0.84670451
126MP0002088_abnormal_embryonic_growth/wei0.84588825
127MP0002733_abnormal_thermal_nociception0.83850075
128MP0001501_abnormal_sleep_pattern0.83721517
129MP0002064_seizures0.83688543
130MP0005645_abnormal_hypothalamus_physiol0.83302623
131MP0004142_abnormal_muscle_tone0.83007434
132MP0002229_neurodegeneration0.82632328
133MP0002184_abnormal_innervation0.80090908
134MP0001270_distended_abdomen0.79602612
135MP0005167_abnormal_blood-brain_barrier0.79210715
136MP0005423_abnormal_somatic_nervous0.78567049
137MP0000470_abnormal_stomach_morphology0.78238510
138MP0005391_vision/eye_phenotype0.78008210
139MP0002152_abnormal_brain_morphology0.77922023
140MP0002111_abnormal_tail_morphology0.76392562
141MP0002269_muscular_atrophy0.75551454
142MP0000049_abnormal_middle_ear0.75545887
143MP0002932_abnormal_joint_morphology0.75262220
144MP0005389_reproductive_system_phenotype0.75214741
145MP0001324_abnormal_eye_pigmentation0.75066196
146MP0003861_abnormal_nervous_system0.74929051
147MP0003136_yellow_coat_color0.73752564
148MP0002075_abnormal_coat/hair_pigmentati0.72434713
149MP0002938_white_spotting0.72109673
150MP0002114_abnormal_axial_skeleton0.71747823
151MP0002092_abnormal_eye_morphology0.70455539
152MP0000462_abnormal_digestive_system0.70402772
153MP0002405_respiratory_system_inflammati0.69635081
154MP0003718_maternal_effect0.69238986
155MP0002116_abnormal_craniofacial_bone0.68438745
156MP0003935_abnormal_craniofacial_develop0.68254568
157MP0002396_abnormal_hematopoietic_system0.68000435
158MP0010307_abnormal_tumor_latency0.67972899
159MP0004264_abnormal_extraembryonic_tissu0.65504926
160MP0003172_abnormal_lysosome_physiology0.64710038
161MP0000432_abnormal_head_morphology0.63957285
162MP0001340_abnormal_eyelid_morphology0.63913200
163MP0005253_abnormal_eye_physiology0.63626205
164MP0004808_abnormal_hematopoietic_stem0.63119797
165MP0005266_abnormal_metabolism0.61061547
166MP0005647_abnormal_sex_gland0.60849222
167MP0000639_abnormal_adrenal_gland0.60185861
168MP0003699_abnormal_female_reproductive0.59679795
169MP0000358_abnormal_cell_content/0.59524214
170MP0003942_abnormal_urinary_system0.59199897
171MP0001119_abnormal_female_reproductive0.58425234
172MP0002751_abnormal_autonomic_nervous0.58047163
173MP0000579_abnormal_nail_morphology0.57460711
174MP0009115_abnormal_fat_cell0.56060780
175MP0000685_abnormal_immune_system0.53564161

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.50071396
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.41828106
3Absent/shortened dynein arms (HP:0200106)7.41828106
4Abnormal respiratory motile cilium physiology (HP:0012261)7.22321973
5Abnormal ciliary motility (HP:0012262)6.25402159
6Rhinitis (HP:0012384)6.18203960
7* Abnormal respiratory motile cilium morphology (HP:0005938)6.05713922
8* Abnormal respiratory epithelium morphology (HP:0012253)6.05713922
9Chronic bronchitis (HP:0004469)5.47021063
10Pancreatic fibrosis (HP:0100732)4.55423306
11Nasal polyposis (HP:0100582)4.52000969
12Male infertility (HP:0003251)4.45345956
13True hermaphroditism (HP:0010459)4.41985055
14* Infertility (HP:0000789)4.06467908
15Pancreatic cysts (HP:0001737)4.05790835
16Abnormality of the nasal mucosa (HP:0000433)3.95843717
17Occipital encephalocele (HP:0002085)3.88057414
18Cystic liver disease (HP:0006706)3.55627394
19Facial hemangioma (HP:0000329)3.54230446
20Chronic sinusitis (HP:0011109)3.53278981
21* Bronchiectasis (HP:0002110)3.50534240
22Rib fusion (HP:0000902)3.45048616
23Chronic hepatic failure (HP:0100626)3.39731264
24Poikiloderma (HP:0001029)3.38876145
25Annular pancreas (HP:0001734)3.32516248
26Concave nail (HP:0001598)3.23923327
27Bronchitis (HP:0012387)3.20661529
28Rectal fistula (HP:0100590)3.18301624
29Rectovaginal fistula (HP:0000143)3.18301624
30Abnormality of the lower motor neuron (HP:0002366)3.08579480
31Tongue fasciculations (HP:0001308)3.06922870
32Supernumerary spleens (HP:0009799)2.99499110
33Vaginal fistula (HP:0004320)2.92890431
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.90969076
35Selective tooth agenesis (HP:0001592)2.83479837
36Short humerus (HP:0005792)2.82177490
37Intestinal atresia (HP:0011100)2.80956631
38Median cleft lip (HP:0000161)2.78155170
39Aplasia/hypoplasia of the humerus (HP:0006507)2.76612927
40Intestinal fistula (HP:0100819)2.75451573
41Nephronophthisis (HP:0000090)2.72651780
42Muscle fibrillation (HP:0010546)2.70221833
43Abnormality of the anterior horn cell (HP:0006802)2.69556783
44Degeneration of anterior horn cells (HP:0002398)2.69556783
45Congenital hepatic fibrosis (HP:0002612)2.63075233
46Anencephaly (HP:0002323)2.61668828
47Increased IgM level (HP:0003496)2.60275710
48Tubulointerstitial nephritis (HP:0001970)2.59873933
49Tubular atrophy (HP:0000092)2.57836394
50Atelectasis (HP:0100750)2.55880299
51Absent thumb (HP:0009777)2.55567840
52Pustule (HP:0200039)2.52456062
53Absent radius (HP:0003974)2.52431897
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.48004486
55Broad alveolar ridges (HP:0000187)2.45580890
56Absent forearm bone (HP:0003953)2.37072298
57Aplasia involving forearm bones (HP:0009822)2.37072298
58Sclerocornea (HP:0000647)2.35942196
59Hypotelorism (HP:0000601)2.34289236
60Hypoplasia of the radius (HP:0002984)2.34039868
61Alopecia of scalp (HP:0002293)2.31612692
62Alacrima (HP:0000522)2.29195381
63Ulnar bowing (HP:0003031)2.28828224
64Orthostatic hypotension (HP:0001278)2.26625398
65Male pseudohermaphroditism (HP:0000037)2.24770279
66Medial flaring of the eyebrow (HP:0010747)2.24252492
67Muscle fiber atrophy (HP:0100295)2.24198761
68Abnormality of male internal genitalia (HP:0000022)2.23984738
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.18590882
70Type 2 muscle fiber atrophy (HP:0003554)2.18528139
71Recurrent sinusitis (HP:0011108)2.15043023
72Gonadotropin excess (HP:0000837)2.13856406
73Squamous cell carcinoma (HP:0002860)2.12479322
74Coronal craniosynostosis (HP:0004440)2.11968253
75Postaxial foot polydactyly (HP:0001830)2.11129419
76Genital tract atresia (HP:0001827)2.11023324
77Vaginal atresia (HP:0000148)2.08426139
78Chronic otitis media (HP:0000389)2.08241779
79Impulsivity (HP:0100710)2.07915912
80Asplenia (HP:0001746)2.07128972
81Hyperactive renin-angiotensin system (HP:0000841)2.05066982
82Patellar aplasia (HP:0006443)1.99984407
83Polydipsia (HP:0001959)1.99979017
84Abnormal drinking behavior (HP:0030082)1.99979017
85Amyotrophic lateral sclerosis (HP:0007354)1.99898409
86Abnormality of the renal cortex (HP:0011035)1.98160008
87* Recurrent otitis media (HP:0000403)1.97993943
88Heterotopia (HP:0002282)1.97951864
89Volvulus (HP:0002580)1.97770190
90Turricephaly (HP:0000262)1.96859854
91Congenital primary aphakia (HP:0007707)1.95537995
92Decreased circulating renin level (HP:0003351)1.94953770
93Abnormality of the ileum (HP:0001549)1.92765245
94Gait imbalance (HP:0002141)1.92623259
95Bell-shaped thorax (HP:0001591)1.92140378
96Basal cell carcinoma (HP:0002671)1.91980086
97Molar tooth sign on MRI (HP:0002419)1.90777307
98Abnormality of midbrain morphology (HP:0002418)1.90777307
99Albinism (HP:0001022)1.89729507
100Oculomotor apraxia (HP:0000657)1.89707610
101Poor coordination (HP:0002370)1.87962644
102Abnormality of the renal medulla (HP:0100957)1.86729359
103Furrowed tongue (HP:0000221)1.86470027
104Preaxial hand polydactyly (HP:0001177)1.86229558
105Hypochromic microcytic anemia (HP:0004840)1.85977329
106Aplasia/Hypoplasia of the patella (HP:0006498)1.85422986
107Premature graying of hair (HP:0002216)1.84941391
108Vertebral hypoplasia (HP:0008417)1.84205991
109Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.84205991
110Bile duct proliferation (HP:0001408)1.83791721
111Abnormal biliary tract physiology (HP:0012439)1.83791721
112Decreased lacrimation (HP:0000633)1.83771758
113Anteriorly placed anus (HP:0001545)1.83755605
114Tubulointerstitial abnormality (HP:0001969)1.82375372
115Gastrointestinal atresia (HP:0002589)1.82194170
116Abnormality of abdominal situs (HP:0011620)1.80016809
117Abdominal situs inversus (HP:0003363)1.80016809
118Dysautonomia (HP:0002459)1.76383780
119Nephroblastoma (Wilms tumor) (HP:0002667)1.73618405
120Abnormality of the aortic arch (HP:0012303)1.73085942
121Abnormality of the labia minora (HP:0012880)1.69778569
122Recurrent bronchitis (HP:0002837)1.69755172
123Decreased central vision (HP:0007663)1.69304337
124Postaxial hand polydactyly (HP:0001162)1.69233853
125Congenital hip dislocation (HP:0001374)1.68890035
126Abnormal hemoglobin (HP:0011902)1.68187319
12711 pairs of ribs (HP:0000878)1.67384905
128Absent speech (HP:0001344)1.67066232
129Nephrogenic diabetes insipidus (HP:0009806)1.66805186
130Diaphragmatic weakness (HP:0009113)1.66334815
131Spinal muscular atrophy (HP:0007269)1.64684542
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.64651799
133Acute lymphatic leukemia (HP:0006721)1.63675631
134Hamartoma (HP:0010566)1.61883246
135Large for gestational age (HP:0001520)1.60202330
136Retinitis pigmentosa (HP:0000510)1.56996630
137Nephropathy (HP:0000112)1.54846747
138Stage 5 chronic kidney disease (HP:0003774)1.53805460
139Narrow forehead (HP:0000341)1.53113887
140Renal salt wasting (HP:0000127)1.44879859
141Tubulointerstitial fibrosis (HP:0005576)1.44332842
142Hyperkalemia (HP:0002153)1.42034896
143Renal dysplasia (HP:0000110)1.41424982
144Abnormal rod and cone electroretinograms (HP:0008323)1.39574613
145Aganglionic megacolon (HP:0002251)1.38948063
146Multicystic kidney dysplasia (HP:0000003)1.38821955
147Prominent nasal bridge (HP:0000426)1.38684805
148Polyuria (HP:0000103)1.38264495
149Abnormality of macular pigmentation (HP:0008002)1.37639688
150Aplasia/Hypoplasia of the lens (HP:0008063)1.36695668
151Highly arched eyebrow (HP:0002553)1.36387080
152Congenital stationary night blindness (HP:0007642)1.35871019
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.34218397
154Abnormality of renin-angiotensin system (HP:0000847)1.34058778
155Anophthalmia (HP:0000528)1.33262865
156Optic nerve coloboma (HP:0000588)1.32003004
157Short thorax (HP:0010306)1.31714616
158Type II lissencephaly (HP:0007260)1.31043463
159Hyperaldosteronism (HP:0000859)1.30765670
160Bony spicule pigmentary retinopathy (HP:0007737)1.28465632
161Specific learning disability (HP:0001328)1.28132261
162Broad foot (HP:0001769)1.27830596
163Hip dysplasia (HP:0001385)1.21706458
164Dandy-Walker malformation (HP:0001305)1.20926878
165Absent frontal sinuses (HP:0002688)1.20061462
166Hyperventilation (HP:0002883)1.19956138
167Abolished electroretinogram (ERG) (HP:0000550)1.17186372
168Holoprosencephaly (HP:0001360)1.16955553
169Progressive cerebellar ataxia (HP:0002073)1.16656043
170Abnormality of renal excretion (HP:0011036)1.16512292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.25114571
2MAPK155.40699515
3FRK3.71248152
4DDR23.62454650
5PDK33.41644481
6PDK43.41644481
7MAP3K63.33828198
8PINK12.84100641
9MATK2.73188210
10TYRO32.66751003
11MST42.60603464
12PIM22.53885461
13MAP3K112.53033986
14WNK42.52182296
15WNK32.41056733
16CASK2.30233219
17BMPR1B2.18855873
18DYRK1B2.06338893
19MAP4K22.05372418
20BCR2.04138933
21DAPK12.02806039
22INSRR2.02650065
23DYRK32.02306914
24EPHA22.02169162
25UHMK11.91322896
26STK391.90091179
27PDK21.89548990
28MAP3K41.87212948
29YES11.84178897
30GRK11.79314994
31CDK71.78194212
32ADRBK21.77033980
33FGR1.75171685
34NEK21.74876451
35WEE11.68495050
36CDC71.67063062
37TESK11.66600144
38MAPK131.63563359
39PRKD21.53617345
40MARK11.52280592
41BUB11.52000868
42NME11.50294539
43CSK1.49311200
44SIK21.49022612
45TLK11.32024227
46CHEK21.31960965
47STK38L1.31752924
48ACVR1B1.31664061
49EPHA31.30650014
50MAP2K71.25153850
51PLK11.23423994
52PIM11.18714669
53BMX1.18532499
54PRKD31.17762221
55CDK61.17157734
56STK241.17043537
57PDGFRA1.14666034
58ATR1.13438344
59EPHA41.10583932
60CDK121.06874196
61RPS6KC11.05672188
62RPS6KL11.05672188
63PHKG11.05574747
64PHKG21.05574747
65PNCK1.03776357
66AKT30.99960294
67PAK30.98727150
68RPS6KA60.91163161
69CAMKK10.89562368
70OXSR10.88189283
71CAMKK20.87917681
72ERBB20.87800309
73NTRK30.87162804
74ADRBK10.86979301
75PRKCG0.86423307
76MAP3K70.85520220
77PRKCI0.83317742
78DYRK1A0.81595860
79FER0.78807369
80ZAK0.77219445
81PRKCE0.76810956
82CAMK1G0.76249929
83MTOR0.75102308
84GSK3A0.73861894
85MAP3K20.71597165
86TRIM280.71379818
87CSNK1G20.71347441
88DAPK20.69499441
89MKNK20.69378240
90TRPM70.68253779
91MAP3K100.67698825
92CDC42BPA0.66982691
93CHEK10.66774247
94AURKA0.66631262
95MAP2K40.66373809
96BCKDK0.66006698
97RPS6KA10.64326661
98TNIK0.64242671
99CAMK10.64159955
100MARK20.61646626
101LATS20.61190905
102NEK60.59321289
103PLK20.59196851
104PRKCQ0.58757992
105TTK0.57464494
106PASK0.56251148
107CDK20.55842048
108MAPK110.55549340
109MUSK0.54731737
110ATM0.54692093
111BRSK20.54594198
112NUAK10.54354536
113DYRK20.54019048
114HIPK20.53998311
115PRKAA20.53869795
116CSNK2A10.52283361
117FGFR20.51190569
118CAMK2A0.50876317
119ERBB30.50534279
120PLK40.49486140
121TIE10.49243321
122PRKAA10.49122902
123RPS6KB20.48114831
124CSNK1G30.47974218
125PRKACA0.47098286
126AURKB0.46710294
127SGK2230.46655533
128SGK4940.46655533
129RPS6KB10.46417237
130STK380.46285874
131PKN10.46180316
132CCNB10.45978651
133NTRK20.45425816
134PRKCZ0.44876139
135MAPKAPK30.44203021
136CSNK1A1L0.42851141
137STK30.41297103
138CSNK2A20.41145101
139MAPKAPK50.40015283
140PAK40.38929939
141TGFBR10.38747930
142ROCK10.38241107
143MINK10.36133205
144RAF10.35825586
145WNK10.35736721
146SGK10.35508996
147PTK2B0.35057645
148CAMK40.34977954
149SGK20.34155985
150BRSK10.33535979
151EEF2K0.32893765
152PRKCA0.32708008
153PAK10.32395591
154CSNK1G10.31935120
155IRAK10.31658937
156PRKCH0.30975344
157CHUK0.30789089
158CDK40.30696953
159TESK20.30623336
160CDK10.30279716
161EGFR0.27853604
162MAPK100.26271128
163SRPK10.24449212
164MAPK40.23921774
165PAK20.23311250
166MAPK10.23088370
167EIF2AK30.21828964
168CDK80.21743932
169RIPK10.21448536
170MAPKAPK20.21357860
171LYN0.21052149
172MAPK140.20656321
173NEK10.20164537
174STK160.18095585
175VRK10.17732929
176EIF2AK10.17672632
177MAPK30.16709773
178MAP4K10.15966574
179PRKDC0.15406979
180MKNK10.15363102

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.71473402
2DNA replication_Homo sapiens_hsa030304.53131251
3Base excision repair_Homo sapiens_hsa034104.52308542
4Fatty acid biosynthesis_Homo sapiens_hsa000614.04090247
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.36658990
6Chemical carcinogenesis_Homo sapiens_hsa052042.94174074
7RNA transport_Homo sapiens_hsa030132.93690885
8Fanconi anemia pathway_Homo sapiens_hsa034602.91921607
9Spliceosome_Homo sapiens_hsa030402.87935703
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.85935946
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82492827
12Nucleotide excision repair_Homo sapiens_hsa034202.82109580
13Histidine metabolism_Homo sapiens_hsa003402.65589782
14mRNA surveillance pathway_Homo sapiens_hsa030152.52564453
15Phenylalanine metabolism_Homo sapiens_hsa003602.49776375
16Homologous recombination_Homo sapiens_hsa034402.49721888
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37018489
18Nicotine addiction_Homo sapiens_hsa050332.27824824
19Phototransduction_Homo sapiens_hsa047442.21640777
20beta-Alanine metabolism_Homo sapiens_hsa004102.15018913
21Tyrosine metabolism_Homo sapiens_hsa003502.10833097
22Basal transcription factors_Homo sapiens_hsa030222.10134406
23Cell cycle_Homo sapiens_hsa041102.07533155
24Caffeine metabolism_Homo sapiens_hsa002322.02767875
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91480239
26Retinol metabolism_Homo sapiens_hsa008301.86705548
27ABC transporters_Homo sapiens_hsa020101.81775132
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72492302
29Hedgehog signaling pathway_Homo sapiens_hsa043401.71276680
30Oocyte meiosis_Homo sapiens_hsa041141.69526370
31Proteasome_Homo sapiens_hsa030501.69367296
32Butanoate metabolism_Homo sapiens_hsa006501.68943463
33Ribosome_Homo sapiens_hsa030101.64620293
34Notch signaling pathway_Homo sapiens_hsa043301.62458050
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.58264330
36Taste transduction_Homo sapiens_hsa047421.54217482
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50416748
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50200108
39Pyrimidine metabolism_Homo sapiens_hsa002401.47852720
40RNA polymerase_Homo sapiens_hsa030201.46067950
41Nitrogen metabolism_Homo sapiens_hsa009101.40530487
42p53 signaling pathway_Homo sapiens_hsa041151.39962851
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36125118
44Peroxisome_Homo sapiens_hsa041461.35861045
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.34960690
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33070573
47Hippo signaling pathway_Homo sapiens_hsa043901.32283250
48RNA degradation_Homo sapiens_hsa030181.27397383
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24684879
50Biosynthesis of amino acids_Homo sapiens_hsa012301.20673634
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19813058
52Salivary secretion_Homo sapiens_hsa049701.19495166
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19280208
54Dorso-ventral axis formation_Homo sapiens_hsa043201.16983489
55Vitamin B6 metabolism_Homo sapiens_hsa007501.16925358
56Basal cell carcinoma_Homo sapiens_hsa052171.15788646
57Circadian rhythm_Homo sapiens_hsa047101.14440037
58mTOR signaling pathway_Homo sapiens_hsa041501.12815824
59Tryptophan metabolism_Homo sapiens_hsa003801.12101851
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11575791
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11444638
62Fatty acid degradation_Homo sapiens_hsa000711.11348656
63Glutamatergic synapse_Homo sapiens_hsa047241.08654757
64Fructose and mannose metabolism_Homo sapiens_hsa000511.07471941
65Huntingtons disease_Homo sapiens_hsa050161.04529048
66Serotonergic synapse_Homo sapiens_hsa047260.99821249
67Wnt signaling pathway_Homo sapiens_hsa043100.98053897
68Sulfur relay system_Homo sapiens_hsa041220.97510466
69Circadian entrainment_Homo sapiens_hsa047130.97429233
70Sphingolipid metabolism_Homo sapiens_hsa006000.96210217
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95646531
72Cocaine addiction_Homo sapiens_hsa050300.94544851
73Ether lipid metabolism_Homo sapiens_hsa005650.93808890
74Axon guidance_Homo sapiens_hsa043600.92532342
75Steroid biosynthesis_Homo sapiens_hsa001000.92411919
76Propanoate metabolism_Homo sapiens_hsa006400.91144330
77Purine metabolism_Homo sapiens_hsa002300.90934760
78Selenocompound metabolism_Homo sapiens_hsa004500.90843181
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90290784
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89707308
81Collecting duct acid secretion_Homo sapiens_hsa049660.89236514
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88678033
83Arginine and proline metabolism_Homo sapiens_hsa003300.87812872
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87807686
85Morphine addiction_Homo sapiens_hsa050320.87602966
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.86470925
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.85738496
88GABAergic synapse_Homo sapiens_hsa047270.82461612
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81798766
90Epstein-Barr virus infection_Homo sapiens_hsa051690.79590335
91Cardiac muscle contraction_Homo sapiens_hsa042600.79518847
92Adherens junction_Homo sapiens_hsa045200.78891438
93TGF-beta signaling pathway_Homo sapiens_hsa043500.78882457
94Pyruvate metabolism_Homo sapiens_hsa006200.78632963
95Glutathione metabolism_Homo sapiens_hsa004800.75728866
96Dopaminergic synapse_Homo sapiens_hsa047280.75369376
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74816988
98N-Glycan biosynthesis_Homo sapiens_hsa005100.74246873
99Pentose phosphate pathway_Homo sapiens_hsa000300.74124280
100Insulin secretion_Homo sapiens_hsa049110.73708699
101Bladder cancer_Homo sapiens_hsa052190.72450978
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72106430
103Viral carcinogenesis_Homo sapiens_hsa052030.71210964
104Glucagon signaling pathway_Homo sapiens_hsa049220.70785160
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.70332147
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69416256
107Calcium signaling pathway_Homo sapiens_hsa040200.69296531
108cAMP signaling pathway_Homo sapiens_hsa040240.68086708
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68070971
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65424410
111VEGF signaling pathway_Homo sapiens_hsa043700.64314025
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63092594
113Ovarian steroidogenesis_Homo sapiens_hsa049130.63090810
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61175235
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60987230
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60880797
117Glycerolipid metabolism_Homo sapiens_hsa005610.60569225
118Amphetamine addiction_Homo sapiens_hsa050310.59702285
119Oxidative phosphorylation_Homo sapiens_hsa001900.59522090
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58900826
121Shigellosis_Homo sapiens_hsa051310.58591520
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.57594360
123Colorectal cancer_Homo sapiens_hsa052100.57054877
124Non-homologous end-joining_Homo sapiens_hsa034500.54484107
125Metabolic pathways_Homo sapiens_hsa011000.54444262
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53919545
127Folate biosynthesis_Homo sapiens_hsa007900.51546323
128Regulation of autophagy_Homo sapiens_hsa041400.51212270
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.51024254
130Synaptic vesicle cycle_Homo sapiens_hsa047210.49677513
131Olfactory transduction_Homo sapiens_hsa047400.49533233
132HTLV-I infection_Homo sapiens_hsa051660.49101166
133Legionellosis_Homo sapiens_hsa051340.48983322
134Starch and sucrose metabolism_Homo sapiens_hsa005000.45524304
135Protein export_Homo sapiens_hsa030600.45321889
136Linoleic acid metabolism_Homo sapiens_hsa005910.44660513
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43754092
138Herpes simplex infection_Homo sapiens_hsa051680.41501526
139AMPK signaling pathway_Homo sapiens_hsa041520.39769553
140Tight junction_Homo sapiens_hsa045300.39276078
141Oxytocin signaling pathway_Homo sapiens_hsa049210.39126774
142MicroRNAs in cancer_Homo sapiens_hsa052060.39111102
143Fatty acid metabolism_Homo sapiens_hsa012120.38968857
144Antigen processing and presentation_Homo sapiens_hsa046120.38929353
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.38879869
146One carbon pool by folate_Homo sapiens_hsa006700.38658698
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37879144
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37854424
149Galactose metabolism_Homo sapiens_hsa000520.37045865
150Acute myeloid leukemia_Homo sapiens_hsa052210.36992890
151Bile secretion_Homo sapiens_hsa049760.36570164
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36268921
153PPAR signaling pathway_Homo sapiens_hsa033200.35666716
154Cholinergic synapse_Homo sapiens_hsa047250.33971989
155Systemic lupus erythematosus_Homo sapiens_hsa053220.33631646
156Primary immunodeficiency_Homo sapiens_hsa053400.32969382
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.32718109
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31808634
159Thyroid cancer_Homo sapiens_hsa052160.30970146
160Lysine degradation_Homo sapiens_hsa003100.27666963
161Chronic myeloid leukemia_Homo sapiens_hsa052200.27366495
162Small cell lung cancer_Homo sapiens_hsa052220.26685967
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26511951
164Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25679293
165Estrogen signaling pathway_Homo sapiens_hsa049150.24763408
166Viral myocarditis_Homo sapiens_hsa054160.24326605
167Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23212041
168Insulin signaling pathway_Homo sapiens_hsa049100.22743719
169Arachidonic acid metabolism_Homo sapiens_hsa005900.21220015
170Pathways in cancer_Homo sapiens_hsa052000.20485510
171Mineral absorption_Homo sapiens_hsa049780.16573897
172Gap junction_Homo sapiens_hsa045400.16309611
173Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15018261

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