CCDC50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.17341382
2positive regulation of interferon-alpha production (GO:0032727)4.03714851
3regulation of dendritic cell antigen processing and presentation (GO:0002604)3.98950482
4retina vasculature morphogenesis in camera-type eye (GO:0061299)3.86867717
5positive regulation of gamma-delta T cell activation (GO:0046645)3.80606684
6chondrocyte proliferation (GO:0035988)3.80323499
7positive regulation of natural killer cell differentiation (GO:0032825)3.79250417
8regulation of interferon-alpha production (GO:0032647)3.78069145
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.77444172
10positive regulation by symbiont of host defense response (GO:0052509)3.75012971
11modulation by symbiont of host defense response (GO:0052031)3.75012971
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75012971
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75012971
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.75012971
15modulation by symbiont of host immune response (GO:0052553)3.75012971
16positive regulation of interleukin-12 production (GO:0032735)3.54594221
17antigen processing and presentation of endogenous antigen (GO:0019883)3.53484672
18ganglion development (GO:0061548)3.50976854
19skin morphogenesis (GO:0043589)3.45874238
20regulation of interferon-beta biosynthetic process (GO:0045357)3.44817212
21negative regulation of fibrinolysis (GO:0051918)3.36851659
22regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.33883998
23positive regulation of antigen processing and presentation (GO:0002579)3.33495371
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.30803115
25growth hormone receptor signaling pathway (GO:0060396)3.30066172
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.28968915
27positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.26597853
28regulation of T-helper 1 cell differentiation (GO:0045625)3.23625342
29lymphangiogenesis (GO:0001946)3.22033466
30cellular response to zinc ion (GO:0071294)3.21949959
31I-kappaB phosphorylation (GO:0007252)3.20226731
32substrate-dependent cell migration (GO:0006929)3.17841735
33paraxial mesoderm development (GO:0048339)3.17364330
34collagen fibril organization (GO:0030199)3.17250651
35negative thymic T cell selection (GO:0045060)3.14150243
36T-helper 1 type immune response (GO:0042088)3.13109456
37neutrophil activation involved in immune response (GO:0002283)3.11390537
38axon extension involved in axon guidance (GO:0048846)3.05747509
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.05747509
40endodermal cell differentiation (GO:0035987)3.05726976
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01389245
42regulation of alpha-beta T cell proliferation (GO:0046640)2.99365352
43macrophage activation involved in immune response (GO:0002281)2.97550647
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95764796
45negative T cell selection (GO:0043383)2.93879093
46actin filament depolymerization (GO:0030042)2.92246103
47myeloid dendritic cell differentiation (GO:0043011)2.91713096
48sequestering of extracellular ligand from receptor (GO:0035581)2.91519157
49response to type I interferon (GO:0034340)2.91296974
50COPII vesicle coating (GO:0048208)2.90286804
51germinal center formation (GO:0002467)2.89553848
52response to muramyl dipeptide (GO:0032495)2.89119637
53wound healing, spreading of epidermal cells (GO:0035313)2.88928315
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88863671
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88863671
56SMAD protein complex assembly (GO:0007183)2.87849037
57type I interferon signaling pathway (GO:0060337)2.87483849
58cellular response to type I interferon (GO:0071357)2.87483849
59tyrosine phosphorylation of STAT protein (GO:0007260)2.87102535
60regulation of interleukin-12 production (GO:0032655)2.86090866
61vascular endothelial growth factor signaling pathway (GO:0038084)2.85753660
62myeloid dendritic cell activation (GO:0001773)2.85304025
63natural killer cell differentiation (GO:0001779)2.85231745
64cell migration involved in sprouting angiogenesis (GO:0002042)2.85149775
65regulation of plasminogen activation (GO:0010755)2.85064627
66pericardium development (GO:0060039)2.84444651
67JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82731814
68positive regulation of B cell differentiation (GO:0045579)2.82716391
69interferon-gamma-mediated signaling pathway (GO:0060333)2.82108320
70defense response to protozoan (GO:0042832)2.81805430
71regulation of B cell receptor signaling pathway (GO:0050855)2.81280449
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78961365
73cellular response to growth hormone stimulus (GO:0071378)2.78877017
74hemidesmosome assembly (GO:0031581)2.78571697
75positive regulation of endothelial cell apoptotic process (GO:2000353)2.78276859
76axon extension (GO:0048675)2.77552006
77basement membrane organization (GO:0071711)2.77482045
78peptidyl-glutamic acid carboxylation (GO:0017187)2.77028959
79protein carboxylation (GO:0018214)2.77028959
80natural killer cell mediated immunity (GO:0002228)2.76448163
81natural killer cell mediated cytotoxicity (GO:0042267)2.76448163
82embryonic retina morphogenesis in camera-type eye (GO:0060059)2.73512880
83regulation of axon extension involved in axon guidance (GO:0048841)2.73357979
84response to peptidoglycan (GO:0032494)2.72168821
85negative regulation of anoikis (GO:2000811)2.71863339
86endocardial cushion development (GO:0003197)2.69770199
87regulation of B cell differentiation (GO:0045577)2.69160224
88NIK/NF-kappaB signaling (GO:0038061)2.68737968
89immunoglobulin mediated immune response (GO:0016064)2.68080586
90Golgi transport vesicle coating (GO:0048200)2.68077564
91COPI coating of Golgi vesicle (GO:0048205)2.68077564
92positive regulation of cardiac muscle hypertrophy (GO:0010613)2.66322422
93positive regulation of muscle hypertrophy (GO:0014742)2.66322422
94regulation of antigen processing and presentation (GO:0002577)2.66148240
95positive regulation of interferon-beta production (GO:0032728)2.66007101
96negative regulation of fatty acid transport (GO:2000192)2.64806313
97negative regulation of B cell proliferation (GO:0030889)2.63766690
98dendritic cell chemotaxis (GO:0002407)2.63557755
99membrane assembly (GO:0071709)2.62953095
100positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62664445
101regulation of interferon-gamma biosynthetic process (GO:0045072)2.61228516
102kidney mesenchyme development (GO:0072074)2.60874721
103regulation of fibrinolysis (GO:0051917)2.59616545
104cell-substrate junction assembly (GO:0007044)2.59317038
105positive regulation of interleukin-2 production (GO:0032743)2.59250261
106neutrophil activation (GO:0042119)2.59110679
107extracellular fibril organization (GO:0043206)2.58372926
108fibroblast migration (GO:0010761)2.57841045
109regulation of activation of Janus kinase activity (GO:0010533)2.57692508
110positive regulation of humoral immune response (GO:0002922)2.57553505
111positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.56641288
112sprouting angiogenesis (GO:0002040)2.56210683
113positive regulation of T-helper cell differentiation (GO:0045624)2.55685681
114regulation of T cell tolerance induction (GO:0002664)2.55504234
115hippo signaling (GO:0035329)2.55294127
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55165169
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54925709
118positive regulation of cytokine biosynthetic process (GO:0042108)2.54801466
119substrate adhesion-dependent cell spreading (GO:0034446)2.53950275
120response to protozoan (GO:0001562)2.53530214
121granulocyte activation (GO:0036230)2.53489193
122cytoplasmic mRNA processing body assembly (GO:0033962)2.53183699
123regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.53163665
124positive regulation of macrophage cytokine production (GO:0060907)2.53098941
125endothelial cell morphogenesis (GO:0001886)2.52974252
126positive regulation of response to biotic stimulus (GO:0002833)2.52829924
127positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.52625264
128regulation of T cell chemotaxis (GO:0010819)2.52362392
129positive regulation of T cell chemotaxis (GO:0010820)2.52362392
130cellular response to interferon-alpha (GO:0035457)2.51048801
131protein heterotrimerization (GO:0070208)2.50703145
132regulation of natural killer cell differentiation (GO:0032823)2.50323119
133positive regulation of extracellular matrix organization (GO:1903055)2.50188514
134fibrinolysis (GO:0042730)2.49985050
135mesodermal cell differentiation (GO:0048333)2.49612105
136positive regulation of type 2 immune response (GO:0002830)2.49546401
137protein retention in ER lumen (GO:0006621)2.49297803
138embryonic foregut morphogenesis (GO:0048617)2.48950889
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48775036
140response to host immune response (GO:0052572)2.48775036
141regulation of T-helper cell differentiation (GO:0045622)2.48376285
142dendritic cell migration (GO:0036336)2.48061070
143regulation of axon guidance (GO:1902667)2.47250989
144positive regulation of osteoblast proliferation (GO:0033690)2.47228657
145cell adhesion mediated by integrin (GO:0033627)2.45532514
146glomerular basement membrane development (GO:0032836)2.45399149
147B cell homeostasis (GO:0001782)2.45074263
148respiratory burst (GO:0045730)2.45000529
149metanephric mesenchyme development (GO:0072075)2.44994760
150wound healing, spreading of cells (GO:0044319)2.43736417
151cellular response to vitamin (GO:0071295)2.43424572
152regulation of transforming growth factor beta2 production (GO:0032909)2.43065359
153detection of molecule of bacterial origin (GO:0032490)2.42983005
154regulation of gamma-delta T cell activation (GO:0046643)2.42505892
155cytokine secretion (GO:0050663)2.42137160
156positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.41526435
157protein localization to endosome (GO:0036010)2.40483625
158B cell receptor signaling pathway (GO:0050853)2.40413303
159response to host (GO:0075136)2.40074890
160response to host defenses (GO:0052200)2.40074890
161response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.40074890
162mitotic sister chromatid cohesion (GO:0007064)2.39589674
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39384486
164regulation of T-helper 1 type immune response (GO:0002825)2.39229675
165regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39128628
166neuron projection extension (GO:1990138)2.38790402
167dendritic cell differentiation (GO:0097028)2.38788211
168positive regulation of p38MAPK cascade (GO:1900745)2.38299703
169type B pancreatic cell proliferation (GO:0044342)2.35900611
170smooth muscle tissue development (GO:0048745)2.35547863
171platelet-derived growth factor receptor signaling pathway (GO:0048008)2.33948070
172negative regulation of axon extension involved in axon guidance (GO:0048843)2.33934662
173vesicle coating (GO:0006901)2.32218263
174blood vessel endothelial cell migration (GO:0043534)2.31514395
175cytoskeleton-dependent cytokinesis (GO:0061640)2.30084054
176positive regulation of cardiac muscle cell differentiation (GO:2000727)2.29443783
177cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29288515
178blood vessel maturation (GO:0001955)2.28008067
179renal filtration (GO:0097205)2.27653624
180glomerular visceral epithelial cell development (GO:0072015)2.27622785
181mitotic cytokinesis (GO:0000281)2.27095462
182positive regulation of axon extension (GO:0045773)2.26752848
183hypotonic response (GO:0006971)2.25916735
184negative regulation of chondrocyte differentiation (GO:0032331)2.25905227
185morphogenesis of an epithelial sheet (GO:0002011)2.23105417
186negative regulation of osteoblast proliferation (GO:0033689)2.22849784
187mesenchymal-epithelial cell signaling (GO:0060638)2.22824300
188barbed-end actin filament capping (GO:0051016)2.22370205
189negative chemotaxis (GO:0050919)2.22329539
190cerebral cortex radially oriented cell migration (GO:0021799)2.22312256
191lung vasculature development (GO:0060426)2.21543919
192peptidyl-proline hydroxylation (GO:0019511)2.20755207
193regulation of anoikis (GO:2000209)2.20128410
194low-density lipoprotein particle clearance (GO:0034383)2.19650294
195regulation of cardiac muscle hypertrophy (GO:0010611)2.17690240
196chondrocyte development (GO:0002063)2.16942317
197apoptotic cell clearance (GO:0043277)2.16915917
198regulation of protein activation cascade (GO:2000257)2.16870185
199regulation of complement activation (GO:0030449)2.15201924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.88620736
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.56963419
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.56203926
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.14057398
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.05174384
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75678268
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48171864
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40233788
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.35368298
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.31065227
11RBPJ_22232070_ChIP-Seq_NCS_Mouse3.05087776
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04193278
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90681853
14E2F7_22180533_ChIP-Seq_HELA_Human2.88340878
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74137627
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56869761
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51278092
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45125341
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.38475387
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33968319
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.32091346
22RUNX_20019798_ChIP-Seq_JUKART_Human2.25449524
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21632028
24* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98874266
25* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97319479
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.92510215
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91255520
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89437221
29VDR_24787735_ChIP-Seq_THP-1_Human1.83671914
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81282333
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.80741199
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75432035
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.70298215
34MYB_26560356_Chip-Seq_TH2_Human1.69621099
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69473552
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68155041
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.67612121
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66905567
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64682823
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60376339
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57660484
42GBX2_23144817_ChIP-Seq_PC3_Human1.56686553
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55892819
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54186256
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51573321
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49917140
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49457782
48PU_27001747_Chip-Seq_BMDM_Mouse1.48273648
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44984249
50MYB_26560356_Chip-Seq_TH1_Human1.43909754
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43740217
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43200104
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40728367
54AHR_22903824_ChIP-Seq_MCF-7_Human1.39347766
55* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37674017
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35818066
57MAF_26560356_Chip-Seq_TH1_Human1.34517288
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34315199
59SCL_19346495_ChIP-Seq_HPC-7_Human1.33152291
60SMAD4_21799915_ChIP-Seq_A2780_Human1.31090115
61VDR_24763502_ChIP-Seq_THP-1_Human1.30291635
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29677752
63CJUN_26792858_Chip-Seq_BT549_Human1.29394116
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28297485
65MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27706224
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27258190
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26607388
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.26533114
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26067891
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25737703
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24462764
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.23003594
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22060472
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.22014280
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21726153
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21619578
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.21340199
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.20975661
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19030879
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18625384
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16954302
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.16790369
83SPI1_23547873_ChIP-Seq_NB4_Human1.16427055
84BRD4_25478319_ChIP-Seq_HGPS_Human1.16053088
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15568336
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15415542
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15394420
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14863202
89MYC_22102868_ChIP-Seq_BL_Human1.14590827
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14289926
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14289926
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14214201
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14157611
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12590889
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12418011
96SPI1_23127762_ChIP-Seq_K562_Human1.12174126
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10537473
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.10462703
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.10462703
100TCF7_22412390_ChIP-Seq_EML_Mouse1.08835717
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.08562568
102GATA3_27048872_Chip-Seq_THYMUS_Human1.07761680
103CLOCK_20551151_ChIP-Seq_293T_Human1.06778974
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.06473765
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.06405927
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06318365
107* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06251365
108* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06251365
109* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05977518
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05832672
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.05158617
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04261196
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.03879588
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.03103431
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.03080306
116TP53_18474530_ChIP-ChIP_U2OS_Human1.03070407
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02252614
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.01524890
119EZH2_22144423_ChIP-Seq_EOC_Human1.01191645
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00595146
121LXR_22158963_ChIP-Seq_LIVER_Mouse0.99985885
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99957293
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99013217
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97935584
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97586308
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96243697
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95918015
128STAT3_23295773_ChIP-Seq_U87_Human0.95912229
129* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94163527
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93971682
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91260882
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90355971
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90247340
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.89266584
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88180448
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88180448
137GATA3_26560356_Chip-Seq_TH2_Human0.85729147
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.84102269
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83506679
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83456890
141UTX_26944678_Chip-Seq_JUKART_Human0.81966416
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81131969
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76999869
144FLI1_27457419_Chip-Seq_LIVER_Mouse0.76169455
145SMRT_27268052_Chip-Seq_Bcells_Human0.75166842
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74730640
147KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74531812
148TP53_16413492_ChIP-PET_HCT116_Human0.72524127
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72091736
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71921521
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71384477
152* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70937271
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70495010
154VDR_21846776_ChIP-Seq_THP-1_Human0.70057136
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69830183
156TP63_23658742_ChIP-Seq_EP156T_Human0.69195639
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69097363
158RXR_22108803_ChIP-Seq_LS180_Human0.68445264
159TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.67332077
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.65365932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.62345042
2MP0001835_abnormal_antigen_presentation4.44012041
3MP0003950_abnormal_plasma_membrane3.98718905
4MP0005257_abnormal_intraocular_pressure3.77297762
5MP0010368_abnormal_lymphatic_system3.61017633
6MP0000569_abnormal_digit_pigmentation3.22093780
7MP0000685_abnormal_immune_system3.02952042
8MP0005387_immune_system_phenotype2.93362214
9MP0001790_abnormal_immune_system2.93362214
10MP0003436_decreased_susceptibility_to2.67892461
11MP0002166_altered_tumor_susceptibility2.65357242
12MP0001800_abnormal_humoral_immune2.62835671
13MP0009785_altered_susceptibility_to2.58733576
14MP0005000_abnormal_immune_tolerance2.51618166
15MP0002148_abnormal_hypersensitivity_rea2.50986254
16MP0005623_abnormal_meninges_morphology2.47583398
17MP0002006_tumorigenesis2.47353040
18MP0002452_abnormal_antigen_presenting2.46382911
19MP0005671_abnormal_response_to2.42371041
20MP0002419_abnormal_innate_immunity2.21534603
21MP0003303_peritoneal_inflammation2.21533935
22MP0001958_emphysema2.11796423
23MP0002723_abnormal_immune_serum2.11037078
24MP0005025_abnormal_response_to2.09109522
25MP0003868_abnormal_feces_composition2.08560716
26MP0003300_gastrointestinal_ulcer2.04423412
27MP0006082_CNS_inflammation2.04042837
28MP0001819_abnormal_immune_cell1.96381885
29MP0002420_abnormal_adaptive_immunity1.93528307
30MP0003705_abnormal_hypodermis_morpholog1.87402588
31MP0002009_preneoplasia1.79557779
32MP0004510_myositis1.77403559
33MP0000751_myopathy1.75459058
34MP0005076_abnormal_cell_differentiation1.74377171
35MP0005171_absent_coat_pigmentation1.71765621
36MP0003385_abnormal_body_wall1.71347632
37MP0003091_abnormal_cell_migration1.66470761
38MP0000534_abnormal_ureter_morphology1.66032028
39MP0001853_heart_inflammation1.63901552
40MP0008438_abnormal_cutaneous_collagen1.61196596
41MP0003448_altered_tumor_morphology1.55017991
42MP0002398_abnormal_bone_marrow1.54496183
43MP0009780_abnormal_chondrocyte_physiolo1.51381883
44MP0005023_abnormal_wound_healing1.50955374
45MP0009278_abnormal_bone_marrow1.50714504
46MP0001346_abnormal_lacrimal_gland1.49260444
47MP0002405_respiratory_system_inflammati1.48866626
48MP0000716_abnormal_immune_system1.48227800
49MP0000733_abnormal_muscle_development1.48099402
50MP0004808_abnormal_hematopoietic_stem1.48064799
51MP0002396_abnormal_hematopoietic_system1.46763439
52MP0003724_increased_susceptibility_to1.46156891
53MP0010352_gastrointestinal_tract_polyps1.46136895
54MP0004947_skin_inflammation1.44633863
55MP0005409_darkened_coat_color1.44470463
56MP0001533_abnormal_skeleton_physiology1.43693869
57MP0000778_abnormal_nervous_system1.43372415
58MP0010307_abnormal_tumor_latency1.43154816
59MP0005197_abnormal_uvea_morphology1.42825729
60MP0005464_abnormal_platelet_physiology1.41702592
61MP0002896_abnormal_bone_mineralization1.38803037
62MP0001845_abnormal_inflammatory_respons1.37697137
63MP0010155_abnormal_intestine_physiology1.35256385
64MP0001879_abnormal_lymphatic_vessel1.33269006
65MP0000013_abnormal_adipose_tissue1.32278057
66MP0002138_abnormal_hepatobiliary_system1.26968607
67MP0009764_decreased_sensitivity_to1.26216383
68MP0003890_abnormal_embryonic-extraembry1.24518404
69MP0001348_abnormal_lacrimal_gland1.23224008
70MP0003252_abnormal_bile_duct1.21545689
71MP0002998_abnormal_bone_remodeling1.21523584
72MP0005408_hypopigmentation1.20591732
73MP0000003_abnormal_adipose_tissue1.20431228
74MP0000689_abnormal_spleen_morphology1.20249200
75MP0010030_abnormal_orbit_morphology1.19533528
76MP0001545_abnormal_hematopoietic_system1.16681072
77MP0005397_hematopoietic_system_phenotyp1.16681072
78MP0005595_abnormal_vascular_smooth1.15439839
79MP0002429_abnormal_blood_cell1.14580018
80MP0006138_congestive_heart_failure1.13120011
81MP0000767_abnormal_smooth_muscle1.13114072
82MP0005164_abnormal_response_to1.11728957
83MP0003566_abnormal_cell_adhesion1.09399740
84MP0002722_abnormal_immune_system1.09291202
85MP0005248_abnormal_Harderian_gland1.08576970
86MP0002933_joint_inflammation1.07092834
87MP0003763_abnormal_thymus_physiology1.06956435
88MP0002139_abnormal_hepatobiliary_system1.06031183
89MP0002060_abnormal_skin_morphology1.05473539
90MP0005187_abnormal_penis_morphology1.04748840
91MP0003045_fibrosis1.04641708
92MP0009384_cardiac_valve_regurgitation1.04292945
93MP0001915_intracranial_hemorrhage1.02612054
94MP0000371_diluted_coat_color1.00377907
95MP0001542_abnormal_bone_strength0.98993900
96MP0009333_abnormal_splenocyte_physiolog0.97887147
97MP0002128_abnormal_blood_circulation0.97472057
98MP0009250_abnormal_appendicular_skeleto0.97446770
99MP0005310_abnormal_salivary_gland0.97287512
100MP0002254_reproductive_system_inflammat0.96005264
101MP0002877_abnormal_melanocyte_morpholog0.95950158
102MP0002168_other_aberrant_phenotype0.94884935
103MP0008469_abnormal_protein_level0.94212283
104MP0001873_stomach_inflammation0.93886975
105MP0001614_abnormal_blood_vessel0.93361862
106MP0006054_spinal_hemorrhage0.92480791
107MP0000858_altered_metastatic_potential0.91691636
108MP0003935_abnormal_craniofacial_develop0.90808987
109MP0005390_skeleton_phenotype0.90802324
110MP0003942_abnormal_urinary_system0.90687146
111MP0005193_abnormal_anterior_eye0.90655504
112MP0003828_pulmonary_edema0.90221796
113MP0002928_abnormal_bile_duct0.88953739
114MP0002925_abnormal_cardiovascular_devel0.87576479
115MP0005508_abnormal_skeleton_morphology0.87098004
116MP0009840_abnormal_foam_cell0.86790717
117MP0005085_abnormal_gallbladder_physiolo0.84877986
118MP0003943_abnormal_hepatobiliary_system0.84842191
119MP0002876_abnormal_thyroid_physiology0.84349739
120MP0002295_abnormal_pulmonary_circulatio0.83945422
121MP0001299_abnormal_eye_distance/0.83499520
122MP0010386_abnormal_urinary_bladder0.83054285
123MP0000762_abnormal_tongue_morphology0.83016741
124MP0003755_abnormal_palate_morphology0.82991475
125MP0005503_abnormal_tendon_morphology0.82429704
126MP0000749_muscle_degeneration0.81970185
127MP0002092_abnormal_eye_morphology0.81406908
128MP0010234_abnormal_vibrissa_follicle0.81243993
129MP0004883_abnormal_blood_vessel0.80775544
130MP0002108_abnormal_muscle_morphology0.80479982
131MP0001270_distended_abdomen0.79247774
132MP0004134_abnormal_chest_morphology0.79095589
133MP0002177_abnormal_outer_ear0.79057018
134MP0000703_abnormal_thymus_morphology0.78527650
135MP0003183_abnormal_peptide_metabolism0.77196620
136MP0003941_abnormal_skin_development0.76994466
137MP0005360_urolithiasis0.76622065
138MP0009697_abnormal_copulation0.76168735
139MP0009053_abnormal_anal_canal0.74993897
140MP0000627_abnormal_mammary_gland0.74384099
141MP0002233_abnormal_nose_morphology0.73722463
142MP0004782_abnormal_surfactant_physiolog0.73594578
143MP0000015_abnormal_ear_pigmentation0.73455324
144MP0000759_abnormal_skeletal_muscle0.73451620
145MP0003195_calcinosis0.73447162
146MP0000249_abnormal_blood_vessel0.73170667
147MP0000428_abnormal_craniofacial_morphol0.72907091
148MP0003453_abnormal_keratinocyte_physiol0.72664031
149MP0002163_abnormal_gland_morphology0.72585172
150MP0005620_abnormal_muscle_contractility0.71823898
151MP0004185_abnormal_adipocyte_glucose0.71809231
152MP0005451_abnormal_body_composition0.71591279
153MP0003787_abnormal_imprinting0.71517040
154MP0004130_abnormal_muscle_cell0.70982491
155MP0009763_increased_sensitivity_to0.69615402
156MP0002697_abnormal_eye_size0.69422898
157MP0001286_abnormal_eye_development0.68916925
158MP0004084_abnormal_cardiac_muscle0.67624674
159MP0002089_abnormal_postnatal_growth/wei0.67462622
160MP0009115_abnormal_fat_cell0.67175899
161MP0001881_abnormal_mammary_gland0.66962415
162MP0005275_abnormal_skin_tensile0.65641283
163MP0002332_abnormal_exercise_endurance0.65560418
164MP0005375_adipose_tissue_phenotype0.64644127
165MP0002282_abnormal_trachea_morphology0.64448407
166MP0003634_abnormal_glial_cell0.63790759
167MP0004087_abnormal_muscle_fiber0.63634791
168MP0000163_abnormal_cartilage_morphology0.63366815
169MP0003279_aneurysm0.62967804
170MP0000432_abnormal_head_morphology0.62756152
171MP0000343_altered_response_to0.62160702
172MP0002972_abnormal_cardiac_muscle0.61804278
173MP0005670_abnormal_white_adipose0.61595151
174MP0003795_abnormal_bone_structure0.61581821
175MP0003937_abnormal_limbs/digits/tail_de0.60137189

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.52053221
2Premature rupture of membranes (HP:0001788)5.48521198
3Aortic dissection (HP:0002647)4.73759371
4Eczematoid dermatitis (HP:0000976)4.60938264
5Recurrent abscess formation (HP:0002722)4.50769001
6Recurrent bacterial skin infections (HP:0005406)4.40520337
7Vascular tortuosity (HP:0004948)4.37107815
8Recurrent gram-negative bacterial infections (HP:0005420)3.51146567
9Autoimmune thrombocytopenia (HP:0001973)3.50958235
10Mediastinal lymphadenopathy (HP:0100721)3.40157168
11Atrophic scars (HP:0001075)3.30958602
12Wormian bones (HP:0002645)3.28933227
13Recurrent viral infections (HP:0004429)3.19103984
14Agammaglobulinemia (HP:0004432)3.11750260
15Neonatal short-limb short stature (HP:0008921)3.05777045
16Syringomyelia (HP:0003396)3.01905492
17Spinal cord lesions (HP:0100561)3.01905492
18Recurrent fungal infections (HP:0002841)3.01770565
19Bladder diverticulum (HP:0000015)2.97009016
20Absent frontal sinuses (HP:0002688)2.95716294
21Soft skin (HP:0000977)2.94732073
22Disinhibition (HP:0000734)2.94512763
23Cellulitis (HP:0100658)2.91011688
24Recurrent skin infections (HP:0001581)2.87463619
25Ankle contracture (HP:0006466)2.84319702
26Follicular hyperkeratosis (HP:0007502)2.84189133
27Vasculitis (HP:0002633)2.83563483
28Hematochezia (HP:0002573)2.80977820
29Retrobulbar optic neuritis (HP:0100654)2.80301127
30Optic neuritis (HP:0100653)2.80301127
31Overgrowth (HP:0001548)2.74105044
32Spinal rigidity (HP:0003306)2.74077738
33Myocardial infarction (HP:0001658)2.71372153
34Arterial thrombosis (HP:0004420)2.69579825
35IgA deficiency (HP:0002720)2.66819744
36Myositis (HP:0100614)2.66417281
37Mitral valve prolapse (HP:0001634)2.64266793
38Mitral stenosis (HP:0001718)2.63636224
39Chronic mucocutaneous candidiasis (HP:0002728)2.63454162
40Recurrent cutaneous fungal infections (HP:0011370)2.63454162
41Abnormality of the fingertips (HP:0001211)2.61309094
42Orchitis (HP:0100796)2.61156906
43Deep venous thrombosis (HP:0002625)2.60212047
44Viral hepatitis (HP:0006562)2.57929512
45Shallow orbits (HP:0000586)2.57833262
46Short 4th metacarpal (HP:0010044)2.52128415
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52128415
48Osteomyelitis (HP:0002754)2.52058585
49Systemic lupus erythematosus (HP:0002725)2.49125097
50Osteolytic defects of the hand bones (HP:0009699)2.48481177
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.48481177
52Vertebral compression fractures (HP:0002953)2.47132648
53Asymmetry of the thorax (HP:0001555)2.45998106
54Chronic otitis media (HP:0000389)2.44854958
55Elevated erythrocyte sedimentation rate (HP:0003565)2.41338475
56Cardiovascular calcification (HP:0011915)2.40929302
57Subacute progressive viral hepatitis (HP:0006572)2.40639869
58Increased IgM level (HP:0003496)2.38270389
59Abnormality of dentin (HP:0010299)2.38077741
60Chronic diarrhea (HP:0002028)2.37071120
61Periodontitis (HP:0000704)2.36759934
62Prostate neoplasm (HP:0100787)2.36743533
63Gingivitis (HP:0000230)2.35203930
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.33788222
65Cortical dysplasia (HP:0002539)2.33698713
66Pulmonary infiltrates (HP:0002113)2.32953303
67Wrist flexion contracture (HP:0001239)2.31468732
68Gastrointestinal infarctions (HP:0005244)2.29246876
69Colitis (HP:0002583)2.28232289
70Meningitis (HP:0001287)2.23348738
71Recurrent pneumonia (HP:0006532)2.20886653
72Wide anterior fontanel (HP:0000260)2.20539520
73Gastrointestinal stroma tumor (HP:0100723)2.20388985
74Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.19805396
75Vertebral arch anomaly (HP:0008438)2.18566974
76Short nail (HP:0001799)2.17913632
77Dilatation of the ascending aorta (HP:0005111)2.16988108
78Hypoplasia of the iris (HP:0007676)2.16905319
79Hyperextensible skin (HP:0000974)2.16314766
80Abnormality of macrophages (HP:0004311)2.14286630
81Basal ganglia calcification (HP:0002135)2.10807517
82Mildly elevated creatine phosphokinase (HP:0008180)2.10787759
83Complement deficiency (HP:0004431)2.10777123
84Recurrent bronchitis (HP:0002837)2.10056142
85Inflammation of the large intestine (HP:0002037)2.09931591
86Aneurysm (HP:0002617)2.08566571
87Recurrent lower respiratory tract infections (HP:0002783)2.07989223
88Persistence of primary teeth (HP:0006335)2.07818262
89Abnormality of the prostate (HP:0008775)2.07301072
90Abnormality of T cell number (HP:0011839)2.06864926
91Increased density of long bones (HP:0006392)2.04136353
92Type 1 muscle fiber predominance (HP:0003803)2.02371775
93Abnormality of complement system (HP:0005339)2.01856288
94Aortic aneurysm (HP:0004942)2.00573499
95Pulmonic stenosis (HP:0001642)2.00309885
96Conjugated hyperbilirubinemia (HP:0002908)2.00021726
97Mitral regurgitation (HP:0001653)1.99186006
98Limited hip movement (HP:0008800)1.98904081
99Obstructive lung disease (HP:0006536)1.98866043
100Chronic obstructive pulmonary disease (HP:0006510)1.98866043
101Abnormality of cells of the lymphoid lineage (HP:0012140)1.97213382
102Joint laxity (HP:0001388)1.95731118
103Striae distensae (HP:0001065)1.95439768
104Inappropriate behavior (HP:0000719)1.95369715
105Cervical subluxation (HP:0003308)1.95344424
106Thoracolumbar scoliosis (HP:0002944)1.95170473
107Macroorchidism (HP:0000053)1.94040681
108Blue sclerae (HP:0000592)1.93710318
109Vascular calcification (HP:0004934)1.92717889
110Fragile skin (HP:0001030)1.92286094
111Abnormality of the frontal sinuses (HP:0002687)1.90941161
112Gastrointestinal inflammation (HP:0004386)1.90768469
113Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90316648
114Abnormality of the acetabulum (HP:0003170)1.90260569
115Broad metatarsal (HP:0001783)1.90258075
116Peritonitis (HP:0002586)1.89401880
117Abnormality of the nasal septum (HP:0000419)1.88707229
118Acute myeloid leukemia (HP:0004808)1.88177279
119Panhypogammaglobulinemia (HP:0003139)1.88126328
120Thick nail (HP:0001805)1.87394984
121Keratoconjunctivitis sicca (HP:0001097)1.86783994
122Aortic regurgitation (HP:0001659)1.86062542
123Glucose intolerance (HP:0000833)1.85038025
124Long toe (HP:0010511)1.84928889
125Lymphopenia (HP:0001888)1.83627944
126Abnormality of the 4th metacarpal (HP:0010012)1.83407946
127Elbow flexion contracture (HP:0002987)1.82768358
128Keratoconjunctivitis (HP:0001096)1.82186482
129Abnormality of the anterior chamber (HP:0000593)1.80931840
130Natal tooth (HP:0000695)1.80288077
131Cutaneous melanoma (HP:0012056)1.79170542
132Flexion contracture of toe (HP:0005830)1.79103447
133Joint contractures involving the joints of the feet (HP:0100492)1.79103447
134Volvulus (HP:0002580)1.78729131
135Knee flexion contracture (HP:0006380)1.78365198
136Emphysema (HP:0002097)1.77869606
137Termporal pattern (HP:0011008)1.77195240
138Insidious onset (HP:0003587)1.77195240
139Camptodactyly of toe (HP:0001836)1.76987452
140Renal duplication (HP:0000075)1.75934491
141Blue irides (HP:0000635)1.75843166
142Cerebral aneurysm (HP:0004944)1.75841010
143Abnormality of the peritoneum (HP:0002585)1.75575984
144Porencephaly (HP:0002132)1.74639402
145Increased variability in muscle fiber diameter (HP:0003557)1.74493132
146Limb-girdle muscle weakness (HP:0003325)1.72146810
147Protruding ear (HP:0000411)1.70929642
148Arthralgia (HP:0002829)1.70657188
149Upper limb amyotrophy (HP:0009129)1.70384075
150Distal upper limb amyotrophy (HP:0007149)1.70384075
151Bradycardia (HP:0001662)1.69649376
152Esophageal varix (HP:0002040)1.69022436
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68827285
154Chest pain (HP:0100749)1.68580496
155Spondylolisthesis (HP:0003302)1.67906546
156Abnormal delivery (HP:0001787)1.67745864
157Bilateral sensorineural hearing impairment (HP:0008619)1.66214182
158Arterial tortuosity (HP:0005116)1.65575790
159Abnormality of the intrinsic pathway (HP:0010989)1.65431665
160Thrombocytosis (HP:0001894)1.64619528
161Leukocytosis (HP:0001974)1.63872122
162T lymphocytopenia (HP:0005403)1.63870397
163Transitional cell carcinoma of the bladder (HP:0006740)1.63833256
164Spontaneous hematomas (HP:0007420)1.63289502
165Bowel diverticulosis (HP:0005222)1.62898347
166Hemoptysis (HP:0002105)1.62629539
167Heterotopia (HP:0002282)1.62446832
168Glomerulonephritis (HP:0000099)1.62433828
169Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62203889
170Abnormality of carpal bone ossification (HP:0006257)1.62184538
171Hypoventilation (HP:0002791)1.62181153
172Hand muscle atrophy (HP:0009130)1.61713070
173Tetraparesis (HP:0002273)1.61280908
174Entropion (HP:0000621)1.60786437
175Coxa vara (HP:0002812)1.60651262
176Cupped ribs (HP:0000887)1.60494454
177Abnormal ossification of hand bones (HP:0005921)1.58230069
178Ulnar bowing (HP:0003031)1.57931758
179Genu recurvatum (HP:0002816)1.55569567
180Ectopia lentis (HP:0001083)1.54659615
181Venous abnormality (HP:0002624)1.53447876
182Aortic valve stenosis (HP:0001650)1.52659535
183Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.52421555
184Hypoalphalipoproteinemia (HP:0003233)1.52326605
185Venous insufficiency (HP:0005293)1.52150393
186Focal segmental glomerulosclerosis (HP:0000097)1.52080676
187Broad palm (HP:0001169)1.50735006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.06361869
2MYLK3.27741546
3JAK32.78788852
4MAP4K12.75615553
5CASK2.70848347
6TIE12.70381526
7MARK12.50271115
8DDR22.37642781
9TYK22.37608969
10PTK22.34946373
11TBK12.28314793
12ERBB32.25885619
13LATS22.21413378
14FGFR32.21119555
15NTRK12.17891766
16MAP3K132.13619337
17ICK2.08310430
18IRAK42.03532405
19TRIB32.01988173
20MET2.00892159
21CHUK1.98579717
22JAK11.98116980
23NEK91.95645280
24AKT31.94692272
25PKN21.85603565
26IKBKB1.83714246
27ERBB41.81422300
28SIK31.80943563
29CAMK1D1.74353748
30CSF1R1.65736206
31STK38L1.65500710
32BLK1.62122802
33IKBKE1.55397616
34MOS1.53980760
35CDK61.53749139
36LIMK11.52914534
37LATS11.48817217
38KIT1.48749347
39EPHA31.48661720
40PAK21.47324435
41TXK1.45882326
42SIK11.44359097
43PTK61.44034859
44NUAK11.43632103
45MAP3K121.41752437
46FRK1.40714629
47TTN1.39005785
48RIPK41.38922054
49CAMK1G1.38360269
50FGFR41.36997747
51IRAK31.35496605
52CDK121.30111491
53MARK31.27320037
54CDK81.27269666
55TGFBR21.24952103
56STK31.24429082
57RPS6KA41.23126729
58TESK11.21560311
59MAP3K61.21163417
60SYK1.20138407
61EPHA21.17146257
62TEC1.15348094
63ITK1.15286749
64MAP3K41.10609777
65HCK1.07578253
66BTK1.02058973
67STK101.01969433
68ROCK11.00914965
69SIK20.97451384
70YES10.97142356
71JAK20.96632107
72MAP3K100.94992667
73ROCK20.94893374
74LRRK20.92727980
75PIM10.91537626
76MAP2K70.91007830
77CSK0.90765882
78LMTK20.90749508
79PAK40.90133346
80TRPM70.89873655
81STK40.85554660
82BCR0.85304601
83PNCK0.84839825
84EEF2K0.82239125
85PRKCQ0.79642291
86PDGFRA0.79624410
87FGFR20.74785633
88* LCK0.74548635
89LYN0.74459078
90BMPR20.72986818
91TGFBR10.71600486
92RIPK10.70666891
93ILK0.69998472
94ZAP700.68986791
95SGK30.68548780
96CDK40.66507098
97IGF1R0.64647598
98CDC42BPA0.63925845
99EIF2AK20.63898419
100PDGFRB0.63543360
101ABL10.63478902
102STK380.63337160
103SGK20.61811952
104GSK3A0.61052223
105TNIK0.60816283
106PAK30.60411212
107EPHB10.60207272
108ARAF0.59786357
109DMPK0.56098798
110DYRK1B0.56039757
111MAP2K10.55986565
112FGFR10.55950868
113NTRK30.54828173
114EPHB20.54708800
115BRD40.54408651
116BMX0.52159596
117KSR10.52024571
118CCNB10.51921923
119PRKCH0.51704488
120BRSK20.51280366
121BMPR1B0.50844665
122* EGFR0.50266893
123CDK180.49484824
124CDK90.49393861
125CSNK1A1L0.48779747
126EIF2AK30.48408510
127CSNK1G20.46826969
128MAPKAPK20.46643798
129CDK150.45990635
130MELK0.44017777
131MAP3K70.43825901
132CDK11A0.43756485
133MST1R0.43186041
134NLK0.42287865
135IRAK10.41775802
136SGK2230.40416174
137SGK4940.40416174
138MAPK70.39700152
139STK240.39584075
140PKN10.39284184
141MAP3K20.38104104
142CDK140.37976436
143KSR20.36271118
144RET0.36223970
145PIK3CG0.35577107
146MAPK110.35426781
147INSR0.35336260
148ATR0.35276909
149MTOR0.35015486
150FER0.34903529
151MAPK40.34899148
152ADRBK10.34709476
153PRKCE0.34663719
154CDC70.34573089
155PIM20.34358340
156PRKD10.34267356
157PRKAA10.33894760
158SCYL20.33514175
159MST40.33274892
160FLT30.33153922

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.56415297
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.54981661
3Allograft rejection_Homo sapiens_hsa053302.54369633
4Graft-versus-host disease_Homo sapiens_hsa053322.46014115
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26676301
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.12924444
7Measles_Homo sapiens_hsa051622.07748523
8B cell receptor signaling pathway_Homo sapiens_hsa046622.04398729
9Staphylococcus aureus infection_Homo sapiens_hsa051502.02703431
10Osteoclast differentiation_Homo sapiens_hsa043802.00208531
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94948340
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91410800
13Viral myocarditis_Homo sapiens_hsa054161.88824731
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.87006738
15Prion diseases_Homo sapiens_hsa050201.85162009
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80995106
17TNF signaling pathway_Homo sapiens_hsa046681.80368183
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79411228
19Legionellosis_Homo sapiens_hsa051341.77639305
20Toxoplasmosis_Homo sapiens_hsa051451.76652522
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75140304
22Autoimmune thyroid disease_Homo sapiens_hsa053201.73186672
23Axon guidance_Homo sapiens_hsa043601.71043662
24Primary immunodeficiency_Homo sapiens_hsa053401.69473090
25Dilated cardiomyopathy_Homo sapiens_hsa054141.65840836
26Pertussis_Homo sapiens_hsa051331.65762933
27Influenza A_Homo sapiens_hsa051641.60281514
28Type I diabetes mellitus_Homo sapiens_hsa049401.57670280
29Malaria_Homo sapiens_hsa051441.56919556
30Herpes simplex infection_Homo sapiens_hsa051681.52241599
31Chronic myeloid leukemia_Homo sapiens_hsa052201.48936676
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.48446993
33Hippo signaling pathway_Homo sapiens_hsa043901.45914819
34Tuberculosis_Homo sapiens_hsa051521.43819459
35Chemokine signaling pathway_Homo sapiens_hsa040621.43112337
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41600030
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39590019
38Hepatitis B_Homo sapiens_hsa051611.37705784
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37442855
40Circadian rhythm_Homo sapiens_hsa047101.35560060
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34420203
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32898110
43Small cell lung cancer_Homo sapiens_hsa052221.32736005
44Antigen processing and presentation_Homo sapiens_hsa046121.28357964
45T cell receptor signaling pathway_Homo sapiens_hsa046601.24244731
46Pancreatic cancer_Homo sapiens_hsa052121.23742661
47Shigellosis_Homo sapiens_hsa051311.23457919
48Protein digestion and absorption_Homo sapiens_hsa049741.23276306
49Apoptosis_Homo sapiens_hsa042101.23025475
50Hematopoietic cell lineage_Homo sapiens_hsa046401.18748637
51Salmonella infection_Homo sapiens_hsa051321.17954099
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15755730
53Prolactin signaling pathway_Homo sapiens_hsa049171.12314114
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12029113
55African trypanosomiasis_Homo sapiens_hsa051431.09064227
56MicroRNAs in cancer_Homo sapiens_hsa052061.08058046
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07429310
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07388850
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.06958247
60PPAR signaling pathway_Homo sapiens_hsa033201.06303195
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06265119
62Acute myeloid leukemia_Homo sapiens_hsa052211.04717796
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02921938
64Asthma_Homo sapiens_hsa053101.02578344
65Gap junction_Homo sapiens_hsa045401.01752382
66Hepatitis C_Homo sapiens_hsa051601.00742958
67Proteoglycans in cancer_Homo sapiens_hsa052050.99756681
68Basal cell carcinoma_Homo sapiens_hsa052170.97997617
69Adherens junction_Homo sapiens_hsa045200.96657542
70Rheumatoid arthritis_Homo sapiens_hsa053230.95770824
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.94610529
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94099600
73Tight junction_Homo sapiens_hsa045300.94098876
74Hedgehog signaling pathway_Homo sapiens_hsa043400.93126759
75HTLV-I infection_Homo sapiens_hsa051660.92358397
76Amoebiasis_Homo sapiens_hsa051460.91810400
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91803538
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90718561
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.88993293
80Platelet activation_Homo sapiens_hsa046110.88913836
81Bladder cancer_Homo sapiens_hsa052190.87977284
82Rap1 signaling pathway_Homo sapiens_hsa040150.83555115
83Prostate cancer_Homo sapiens_hsa052150.83513833
84Cocaine addiction_Homo sapiens_hsa050300.82425624
85Viral carcinogenesis_Homo sapiens_hsa052030.81914764
86ErbB signaling pathway_Homo sapiens_hsa040120.81231092
87Focal adhesion_Homo sapiens_hsa045100.80558142
88Colorectal cancer_Homo sapiens_hsa052100.78879523
89Melanogenesis_Homo sapiens_hsa049160.77305245
90Phenylalanine metabolism_Homo sapiens_hsa003600.76712681
91Phagosome_Homo sapiens_hsa041450.76323986
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76209737
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75989318
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.74631664
95Estrogen signaling pathway_Homo sapiens_hsa049150.74555839
96Bile secretion_Homo sapiens_hsa049760.73852892
97Ras signaling pathway_Homo sapiens_hsa040140.71654602
98Endometrial cancer_Homo sapiens_hsa052130.69888996
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.69789269
100Non-small cell lung cancer_Homo sapiens_hsa052230.69168058
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.69149027
102Wnt signaling pathway_Homo sapiens_hsa043100.68417867
103Thyroid hormone synthesis_Homo sapiens_hsa049180.67773355
104FoxO signaling pathway_Homo sapiens_hsa040680.65617428
105AMPK signaling pathway_Homo sapiens_hsa041520.64734775
106Notch signaling pathway_Homo sapiens_hsa043300.64680023
107Insulin resistance_Homo sapiens_hsa049310.64094003
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62685734
109Tyrosine metabolism_Homo sapiens_hsa003500.62142422
110Dopaminergic synapse_Homo sapiens_hsa047280.60942423
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60680219
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60287868
113HIF-1 signaling pathway_Homo sapiens_hsa040660.59634864
114Lysine degradation_Homo sapiens_hsa003100.58987132
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58522027
116Epstein-Barr virus infection_Homo sapiens_hsa051690.57360692
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.57280715
118Glioma_Homo sapiens_hsa052140.57191132
119Type II diabetes mellitus_Homo sapiens_hsa049300.56487827
120TGF-beta signaling pathway_Homo sapiens_hsa043500.56282160
121Renal cell carcinoma_Homo sapiens_hsa052110.56217079
122Pathways in cancer_Homo sapiens_hsa052000.54009809
123Complement and coagulation cascades_Homo sapiens_hsa046100.53590053
124GnRH signaling pathway_Homo sapiens_hsa049120.53521423
125Insulin signaling pathway_Homo sapiens_hsa049100.53114910
126Choline metabolism in cancer_Homo sapiens_hsa052310.53031611
127mTOR signaling pathway_Homo sapiens_hsa041500.52065380
128Long-term depression_Homo sapiens_hsa047300.50682491
129Endocytosis_Homo sapiens_hsa041440.50142215
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49235364
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49128716
132ECM-receptor interaction_Homo sapiens_hsa045120.49032637
133Thyroid cancer_Homo sapiens_hsa052160.47909137
134Melanoma_Homo sapiens_hsa052180.47142758
135MAPK signaling pathway_Homo sapiens_hsa040100.46992770
136Dorso-ventral axis formation_Homo sapiens_hsa043200.46493346
137Cholinergic synapse_Homo sapiens_hsa047250.46263682
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46112131
139VEGF signaling pathway_Homo sapiens_hsa043700.44832906
140Starch and sucrose metabolism_Homo sapiens_hsa005000.44488868
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43988883
142N-Glycan biosynthesis_Homo sapiens_hsa005100.43174607
143p53 signaling pathway_Homo sapiens_hsa041150.41744318
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41245340
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41225708
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.41200506
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40610280
148Renin secretion_Homo sapiens_hsa049240.39664363
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.38429968
150Systemic lupus erythematosus_Homo sapiens_hsa053220.34408090

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