CCDC51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.22513035
2DNA deamination (GO:0045006)5.79406737
3ATP synthesis coupled proton transport (GO:0015986)5.61181853
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.61181853
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.85479775
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.78744410
7regulation of mitochondrial translation (GO:0070129)4.50066260
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46511695
9chaperone-mediated protein transport (GO:0072321)4.40950951
10telomere maintenance via semi-conservative replication (GO:0032201)4.40497647
11respiratory electron transport chain (GO:0022904)4.37345889
12electron transport chain (GO:0022900)4.30238012
13nucleobase biosynthetic process (GO:0046112)4.22674319
14cellular glucuronidation (GO:0052695)4.17948402
15DNA strand elongation involved in DNA replication (GO:0006271)4.16764867
16purine nucleobase biosynthetic process (GO:0009113)4.13730970
17negative regulation of ligase activity (GO:0051352)4.06793073
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.06793073
19pyrimidine nucleotide catabolic process (GO:0006244)3.99086053
20uronic acid metabolic process (GO:0006063)3.92483337
21glucuronate metabolic process (GO:0019585)3.92483337
22folic acid metabolic process (GO:0046655)3.88784359
23DNA strand elongation (GO:0022616)3.88671886
24ribosomal small subunit assembly (GO:0000028)3.87537359
25spliceosomal snRNP assembly (GO:0000387)3.86086442
26proteasome assembly (GO:0043248)3.84729351
27telomere maintenance via recombination (GO:0000722)3.82156899
28base-excision repair, AP site formation (GO:0006285)3.75571695
29protein complex biogenesis (GO:0070271)3.74390495
30DNA damage response, detection of DNA damage (GO:0042769)3.72966226
31establishment of integrated proviral latency (GO:0075713)3.72506352
32mitochondrial respiratory chain complex assembly (GO:0033108)3.71718877
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.69778219
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.69778219
35formation of translation preinitiation complex (GO:0001731)3.68328698
36inner mitochondrial membrane organization (GO:0007007)3.68144961
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.62381108
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62381108
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60442905
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.60442905
41NADH dehydrogenase complex assembly (GO:0010257)3.60442905
42protein neddylation (GO:0045116)3.60263207
43signal transduction involved in cell cycle checkpoint (GO:0072395)3.55399845
44oxidative phosphorylation (GO:0006119)3.54445328
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52378373
46cellular component biogenesis (GO:0044085)3.50811284
47maturation of SSU-rRNA (GO:0030490)3.48443548
48maturation of 5.8S rRNA (GO:0000460)3.48073877
49mitotic recombination (GO:0006312)3.44491851
50protein targeting to mitochondrion (GO:0006626)3.43120246
51viral transcription (GO:0019083)3.42557518
52CENP-A containing nucleosome assembly (GO:0034080)3.42322669
53chromatin remodeling at centromere (GO:0031055)3.41583439
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.40186481
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39627861
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37733088
57ribosome biogenesis (GO:0042254)3.35630775
58positive regulation of ligase activity (GO:0051351)3.35521437
59translational termination (GO:0006415)3.34518503
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34020216
61folic acid-containing compound biosynthetic process (GO:0009396)3.31819362
62pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29695004
63folic acid transport (GO:0015884)3.27718783
64pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.27569526
65ribosome assembly (GO:0042255)3.27348588
66glycine metabolic process (GO:0006544)3.26371719
67protein complex disassembly (GO:0043241)3.25853209
68establishment of protein localization to mitochondrion (GO:0072655)3.25838473
69telomere maintenance via telomere lengthening (GO:0010833)3.23434508
70protein localization to mitochondrion (GO:0070585)3.22394141
71nucleoside salvage (GO:0043174)3.21527763
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20666778
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20666778
74regulation of ubiquitin-protein transferase activity (GO:0051438)3.17839386
75lysine metabolic process (GO:0006553)3.17191701
76lysine catabolic process (GO:0006554)3.17191701
77nuclear-transcribed mRNA catabolic process (GO:0000956)3.16750460
78respiratory chain complex IV assembly (GO:0008535)3.16610764
79translational elongation (GO:0006414)3.16180717
80establishment of viral latency (GO:0019043)3.16008702
81macromolecular complex disassembly (GO:0032984)3.15156157
82DNA replication initiation (GO:0006270)3.14328803
83peptidyl-histidine modification (GO:0018202)3.12537312
84pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.11424369
85ribonucleoprotein complex biogenesis (GO:0022613)3.10622656
86ribosomal small subunit biogenesis (GO:0042274)3.10481875
87purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08552174
88transcription elongation from RNA polymerase III promoter (GO:0006385)3.07452956
89termination of RNA polymerase III transcription (GO:0006386)3.07452956
90ATP biosynthetic process (GO:0006754)3.07434614
91rRNA modification (GO:0000154)3.05878024
92protein targeting to membrane (GO:0006612)3.05739350
93translational initiation (GO:0006413)3.05563680
94regulation of ligase activity (GO:0051340)3.05117085
95mitochondrial RNA metabolic process (GO:0000959)3.04386988
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03966705
97IMP biosynthetic process (GO:0006188)3.00563234
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99540259
99transcription-coupled nucleotide-excision repair (GO:0006283)2.93513316
100rRNA processing (GO:0006364)2.92575771
101cullin deneddylation (GO:0010388)2.91066167
102cotranslational protein targeting to membrane (GO:0006613)2.89519939
103protein targeting to ER (GO:0045047)2.88382754
104folic acid-containing compound metabolic process (GO:0006760)2.87903884
105DNA replication checkpoint (GO:0000076)2.84690129
106ribosomal large subunit biogenesis (GO:0042273)2.82923049
107serine family amino acid biosynthetic process (GO:0009070)2.81723691
108IMP metabolic process (GO:0046040)2.80851771
109telomere maintenance via telomerase (GO:0007004)2.80765207
110protein deneddylation (GO:0000338)2.80271299
111deoxyribonucleotide catabolic process (GO:0009264)2.80241303
112DNA unwinding involved in DNA replication (GO:0006268)2.79715257
113pyrimidine-containing compound salvage (GO:0008655)2.78561822
114pyrimidine nucleoside salvage (GO:0043097)2.78561822
115rRNA metabolic process (GO:0016072)2.78531278
116RNA-dependent DNA replication (GO:0006278)2.78245974
117protein localization to endoplasmic reticulum (GO:0070972)2.77964376
118UMP biosynthetic process (GO:0006222)2.76537914
119pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.76537914
120UMP metabolic process (GO:0046049)2.76537914
121pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.76537914
122deoxyribose phosphate catabolic process (GO:0046386)2.75782637
123metallo-sulfur cluster assembly (GO:0031163)2.75611359
124iron-sulfur cluster assembly (GO:0016226)2.75611359
125tetrahydrofolate metabolic process (GO:0046653)2.74185779
126translation (GO:0006412)2.73566608
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73182988
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71574405
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70847319
130establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70145751
131mitotic metaphase plate congression (GO:0007080)2.68189875
132L-phenylalanine metabolic process (GO:0006558)2.67833474
133erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67833474
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67375309
135L-methionine biosynthetic process (GO:0071265)2.67154682
136amino acid salvage (GO:0043102)2.67154682
137L-methionine salvage (GO:0071267)2.67154682
138regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66796121
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66354260
140valine metabolic process (GO:0006573)2.66024926
141cellular protein complex disassembly (GO:0043624)2.64348084
142regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64004703
143regulation of cellular amino acid metabolic process (GO:0006521)2.63302399
144serine family amino acid metabolic process (GO:0009069)2.61764349
145DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60599638
146pteridine-containing compound biosynthetic process (GO:0042559)2.60566703
147rRNA methylation (GO:0031167)2.57053688
148viral life cycle (GO:0019058)2.56104670
149pseudouridine synthesis (GO:0001522)2.55553818
150signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55240045
151signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55240045
152signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55240045
153cellular metabolic compound salvage (GO:0043094)2.55080868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72961680
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81237574
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.62296876
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90761262
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74685189
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.70921832
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70487286
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.59746415
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59457530
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55020010
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.53897332
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.47795888
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40581426
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37740323
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33505668
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31623648
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31380706
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30039397
19AR_21909140_ChIP-Seq_LNCAP_Human2.26102135
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06950411
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03320305
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02678672
23* XRN2_22483619_ChIP-Seq_HELA_Human1.98744741
24DCP1A_22483619_ChIP-Seq_HELA_Human1.97445898
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96847291
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95804214
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93510783
28VDR_23849224_ChIP-Seq_CD4+_Human1.91903184
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84245183
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.80199358
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79843397
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79762838
33MYC_22102868_ChIP-Seq_BL_Human1.77278310
34* GABP_19822575_ChIP-Seq_HepG2_Human1.75935600
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75515598
36FOXP3_21729870_ChIP-Seq_TREG_Human1.74896980
37MYC_18940864_ChIP-ChIP_HL60_Human1.74424238
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73998148
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71601960
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71019099
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69837835
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69307598
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67091208
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64358373
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63304611
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59156452
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.58987671
48* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56625010
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55068193
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51498291
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49472412
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47948187
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44361942
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.43075610
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41362951
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40601893
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36682549
58KDM5A_27292631_Chip-Seq_BREAST_Human1.35978763
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34597776
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33200131
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29806867
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29342112
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.27367718
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27017081
65ZNF263_19887448_ChIP-Seq_K562_Human1.25912599
66CIITA_25753668_ChIP-Seq_RAJI_Human1.23828017
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22340044
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22244266
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.22188498
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20939566
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19977127
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17564521
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17390061
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15747635
75TTF2_22483619_ChIP-Seq_HELA_Human1.15741557
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15604630
77SPI1_23547873_ChIP-Seq_NB4_Human1.14404839
78ELK1_19687146_ChIP-ChIP_HELA_Human1.14145686
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12067469
80VDR_21846776_ChIP-Seq_THP-1_Human1.11021759
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10701641
82GATA1_22025678_ChIP-Seq_K562_Human1.10170157
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.08664133
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07123246
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06354225
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06204638
87* TFEB_21752829_ChIP-Seq_HELA_Human1.05662388
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.05042480
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04661175
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00900375
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00833438
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00075533
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.99667705
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99138750
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98350685
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98344576
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.97339535
98SCL_19346495_ChIP-Seq_HPC-7_Human0.97154828
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96905309
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96163932
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95549550
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95303215
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.95218533
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94560663
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.94090561
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92984922
107CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92578216
108IRF1_19129219_ChIP-ChIP_H3396_Human0.92530035
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92428343
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91202851
111* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90279097
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88137968
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84605886
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84249846
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83670223
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.82314110
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81534863
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79670208
119ZNF274_21170338_ChIP-Seq_K562_Hela0.75875563
120* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73947575
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71418796
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.69637176
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68510288
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67470479
125* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64768016
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64635593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008007_abnormal_cellular_replicative3.45180014
2MP0003693_abnormal_embryo_hatching3.41714218
3MP0003806_abnormal_nucleotide_metabolis3.18925424
4MP0008058_abnormal_DNA_repair2.95351860
5MP0010094_abnormal_chromosome_stability2.92142742
6MP0002254_reproductive_system_inflammat2.89640453
7MP0003111_abnormal_nucleus_morphology2.83687420
8MP0005360_urolithiasis2.83683429
9MP0002139_abnormal_hepatobiliary_system2.82511621
10MP0004957_abnormal_blastocyst_morpholog2.80784952
11MP0003786_premature_aging2.70730585
12MP0009840_abnormal_foam_cell2.68018944
13MP0005365_abnormal_bile_salt2.60601306
14MP0010030_abnormal_orbit_morphology2.59304389
15MP0002938_white_spotting2.58486457
16MP0008875_abnormal_xenobiotic_pharmacok2.54339526
17MP0005085_abnormal_gallbladder_physiolo2.53157537
18MP0003077_abnormal_cell_cycle2.48672800
19MP0008057_abnormal_DNA_replication2.32532883
20MP0004233_abnormal_muscle_weight2.25144886
21MP0006072_abnormal_retinal_apoptosis2.17505972
22MP0006292_abnormal_olfactory_placode2.15221823
23MP0003186_abnormal_redox_activity2.07925926
24MP0001346_abnormal_lacrimal_gland2.07376182
25MP0010329_abnormal_lipoprotein_level2.01342355
26MP0001529_abnormal_vocalization2.01032880
27MP0005397_hematopoietic_system_phenotyp2.01013082
28MP0001545_abnormal_hematopoietic_system2.01013082
29MP0001293_anophthalmia1.94211748
30MP0002396_abnormal_hematopoietic_system1.93934203
31MP0009697_abnormal_copulation1.93655966
32MP0000566_synostosis1.87492432
33MP0003656_abnormal_erythrocyte_physiolo1.87361755
34MP0001764_abnormal_homeostasis1.63581818
35MP0009333_abnormal_splenocyte_physiolog1.62357886
36MP0004147_increased_porphyrin_level1.61484541
37MP0006036_abnormal_mitochondrial_physio1.60722611
38MP0005332_abnormal_amino_acid1.60176797
39MP0003011_delayed_dark_adaptation1.58523351
40MP0008789_abnormal_olfactory_epithelium1.55593488
41MP0008995_early_reproductive_senescence1.54675103
42MP0005075_abnormal_melanosome_morpholog1.49836622
43MP0002102_abnormal_ear_morphology1.47866116
44MP0003195_calcinosis1.46437263
45MP0008877_abnormal_DNA_methylation1.44858257
46MP0003315_abnormal_perineum_morphology1.44449269
47MP0000609_abnormal_liver_physiology1.44150530
48MP0002132_abnormal_respiratory_system1.43205896
49MP0004808_abnormal_hematopoietic_stem1.41908080
50MP0003191_abnormal_cellular_cholesterol1.41135906
51MP0002163_abnormal_gland_morphology1.35593546
52MP0002736_abnormal_nociception_after1.33854450
53MP0000689_abnormal_spleen_morphology1.32248656
54MP0000537_abnormal_urethra_morphology1.31472953
55MP0000350_abnormal_cell_proliferation1.31356727
56MP0003941_abnormal_skin_development1.29722604
57MP0002009_preneoplasia1.29332548
58MP0005319_abnormal_enzyme/_coenzyme1.28803664
59MP0000598_abnormal_liver_morphology1.27427443
60MP0003436_decreased_susceptibility_to1.27089157
61MP0000579_abnormal_nail_morphology1.25297998
62MP0001730_embryonic_growth_arrest1.25076567
63MP0002234_abnormal_pharynx_morphology1.24195858
64MP0002722_abnormal_immune_system1.24106162
65MP0002210_abnormal_sex_determination1.23134197
66MP0003718_maternal_effect1.21515437
67MP0003763_abnormal_thymus_physiology1.19952319
68MP0003136_yellow_coat_color1.18165110
69MP0001835_abnormal_antigen_presentation1.18003620
70MP0002166_altered_tumor_susceptibility1.17390614
71MP0003937_abnormal_limbs/digits/tail_de1.17063920
72MP0009643_abnormal_urine_homeostasis1.13723379
73MP0005499_abnormal_olfactory_system1.11407956
74MP0005394_taste/olfaction_phenotype1.11407956
75MP0000647_abnormal_sebaceous_gland1.11141335
76MP0002398_abnormal_bone_marrow1.10387558
77MP0002697_abnormal_eye_size1.08835004
78MP0005395_other_phenotype1.07558314
79MP0001800_abnormal_humoral_immune1.06941372
80MP0009379_abnormal_foot_pigmentation1.05612090
81MP0001929_abnormal_gametogenesis1.05436676
82MP0003828_pulmonary_edema1.04785620
83MP0000685_abnormal_immune_system1.04363110
84MP0005253_abnormal_eye_physiology1.03229974
85MP0002019_abnormal_tumor_incidence1.02376416
86MP0000372_irregular_coat_pigmentation1.02224266
87MP0001697_abnormal_embryo_size1.02157292
88MP0005084_abnormal_gallbladder_morpholo1.02081061
89MP0008469_abnormal_protein_level1.01759461
90MP0001145_abnormal_male_reproductive1.00531919
91MP0010352_gastrointestinal_tract_polyps1.00451191
92MP0000490_abnormal_crypts_of0.98701525
93MP0005671_abnormal_response_to0.98611421
94MP0000653_abnormal_sex_gland0.97709033
95MP0003252_abnormal_bile_duct0.95780799
96MP0003119_abnormal_digestive_system0.94913044
97MP0002269_muscular_atrophy0.94848455
98MP0006035_abnormal_mitochondrial_morpho0.94653280
99MP0001286_abnormal_eye_development0.94230465
100MP0002429_abnormal_blood_cell0.93964425
101MP0001672_abnormal_embryogenesis/_devel0.93549265
102MP0005380_embryogenesis_phenotype0.93549265
103MP0002277_abnormal_respiratory_mucosa0.92986326
104MP0005379_endocrine/exocrine_gland_phen0.92685266
105MP0003705_abnormal_hypodermis_morpholog0.91761843
106MP0009785_altered_susceptibility_to0.91546666
107MP0000313_abnormal_cell_death0.90401196
108MP0003890_abnormal_embryonic-extraembry0.90311290
109MP0002168_other_aberrant_phenotype0.90259943
110MP0005025_abnormal_response_to0.90037602
111MP0005083_abnormal_biliary_tract0.89960252
112MP0003878_abnormal_ear_physiology0.89807889
113MP0005377_hearing/vestibular/ear_phenot0.89807889
114MP0001666_abnormal_nutrient_absorption0.89689540
115MP0002085_abnormal_embryonic_tissue0.89624306
116MP0000716_abnormal_immune_system0.89454998
117MP0003567_abnormal_fetal_cardiomyocyte0.89295909
118MP0004133_heterotaxia0.89009686
119MP0000358_abnormal_cell_content/0.88995755
120MP0002877_abnormal_melanocyte_morpholog0.88876211
121MP0003283_abnormal_digestive_organ0.88685071
122MP0010307_abnormal_tumor_latency0.87816499
123MP0002111_abnormal_tail_morphology0.87196578
124MP0002080_prenatal_lethality0.87178267
125MP0001661_extended_life_span0.85604687
126MP0004142_abnormal_muscle_tone0.85006015
127MP0001905_abnormal_dopamine_level0.84916546
128MP0005266_abnormal_metabolism0.84783074
129MP0001727_abnormal_embryo_implantation0.84670818
130MP0004019_abnormal_vitamin_homeostasis0.83405499
131MP0005391_vision/eye_phenotype0.83149704
132MP0003938_abnormal_ear_development0.82713697
133MP0002723_abnormal_immune_serum0.82698295
134MP0000747_muscle_weakness0.82573037
135MP0002837_dystrophic_cardiac_calcinosis0.82481119
136MP0002233_abnormal_nose_morphology0.82245563
137MP0005389_reproductive_system_phenotype0.81995574
138MP0001919_abnormal_reproductive_system0.81607764
139MP0002084_abnormal_developmental_patter0.80772253
140MP0002452_abnormal_antigen_presenting0.79917466
141MP0005584_abnormal_enzyme/coenzyme_acti0.78823636
142MP0001324_abnormal_eye_pigmentation0.78094374
143MP0005408_hypopigmentation0.77587833
144MP0002420_abnormal_adaptive_immunity0.77355309
145MP0002088_abnormal_embryonic_growth/wei0.76994380
146MP0002160_abnormal_reproductive_system0.76687830
147MP0002148_abnormal_hypersensitivity_rea0.76686894
148MP0003984_embryonic_growth_retardation0.76330682
149MP0001119_abnormal_female_reproductive0.76317931
150MP0002118_abnormal_lipid_homeostasis0.76199105
151MP0001819_abnormal_immune_cell0.76182983
152MP0005464_abnormal_platelet_physiology0.75633246
153MP0002136_abnormal_kidney_physiology0.74632751
154MP0002282_abnormal_trachea_morphology0.74232585
155MP0000703_abnormal_thymus_morphology0.73612792
156MP0002405_respiratory_system_inflammati0.73304994
157MP0005451_abnormal_body_composition0.72993839
158MP0008873_increased_physiological_sensi0.72947518
159MP0005376_homeostasis/metabolism_phenot0.72899242
160MP0002095_abnormal_skin_pigmentation0.72282956
161MP0001845_abnormal_inflammatory_respons0.71959898
162MP0002638_abnormal_pupillary_reflex0.71845121
163MP0001881_abnormal_mammary_gland0.70753623
164MP0000049_abnormal_middle_ear0.69597318
165MP0003698_abnormal_male_reproductive0.69452480
166MP0009672_abnormal_birth_weight0.69436848
167MP0002006_tumorigenesis0.69423525
168MP0005636_abnormal_mineral_homeostasis0.69144285
169MP0008932_abnormal_embryonic_tissue0.68923363

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.27969751
2Abnormal mitochondria in muscle tissue (HP:0008316)5.00923355
3Acute encephalopathy (HP:0006846)4.81353297
4Mitochondrial inheritance (HP:0001427)4.76510272
5Microretrognathia (HP:0000308)4.47038969
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.44976198
7Increased hepatocellular lipid droplets (HP:0006565)4.32596009
8Progressive macrocephaly (HP:0004481)4.19941068
9Thrombocytosis (HP:0001894)4.10972728
10Lipid accumulation in hepatocytes (HP:0006561)4.04299582
11Posterior subcapsular cataract (HP:0007787)3.87161393
12Cerebral edema (HP:0002181)3.69586791
13Birth length less than 3rd percentile (HP:0003561)3.59936123
14Microvesicular hepatic steatosis (HP:0001414)3.52962840
15Hyperglycinuria (HP:0003108)3.52288801
163-Methylglutaconic aciduria (HP:0003535)3.46315133
17Hyperglycinemia (HP:0002154)3.24108517
18Pustule (HP:0200039)3.24048637
19Increased intramyocellular lipid droplets (HP:0012240)3.18144275
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.17408551
21Abnormality of glycine metabolism (HP:0010895)3.17110464
22Abnormality of serine family amino acid metabolism (HP:0010894)3.17110464
23Polycythemia (HP:0001901)3.15117563
24Abnormality of aromatic amino acid family metabolism (HP:0004338)3.13081536
25Abnormality of cells of the erythroid lineage (HP:0012130)3.11265272
26Abnormal number of erythroid precursors (HP:0012131)3.08888645
27Hypobetalipoproteinemia (HP:0003563)3.08447019
28Renal Fanconi syndrome (HP:0001994)3.07863193
29Type I transferrin isoform profile (HP:0003642)3.05781719
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.05179611
31Multiple enchondromatosis (HP:0005701)2.98772735
32Exercise intolerance (HP:0003546)2.96221882
33Vacuolated lymphocytes (HP:0001922)2.94353521
34Congenital, generalized hypertrichosis (HP:0004540)2.90318146
35Increased serum pyruvate (HP:0003542)2.89274254
3611 pairs of ribs (HP:0000878)2.83024596
37Tinnitus (HP:0000360)2.81813901
38Respiratory failure (HP:0002878)2.77182086
39Hepatic necrosis (HP:0002605)2.74655623
40Generalized aminoaciduria (HP:0002909)2.72888878
41Capillary hemangiomas (HP:0005306)2.72507445
42Abnormality of glycolysis (HP:0004366)2.71738608
43Increased muscle lipid content (HP:0009058)2.64430526
44Intrahepatic cholestasis (HP:0001406)2.61691751
45Abnormal protein glycosylation (HP:0012346)2.59900318
46Abnormal glycosylation (HP:0012345)2.59900318
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59900318
48Abnormal protein N-linked glycosylation (HP:0012347)2.59900318
49Leukodystrophy (HP:0002415)2.55769468
50Abnormality of serum amino acid levels (HP:0003112)2.52369898
51Optic disc pallor (HP:0000543)2.51543074
52Spontaneous abortion (HP:0005268)2.51322435
53Hyperammonemia (HP:0001987)2.49639273
54Abnormality of fatty-acid metabolism (HP:0004359)2.48003921
55Oral leukoplakia (HP:0002745)2.42063692
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41705116
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41048540
58Macrocytic anemia (HP:0001972)2.39834542
59Respiratory difficulties (HP:0002880)2.39572930
60Hepatocellular necrosis (HP:0001404)2.39535731
61Xanthomatosis (HP:0000991)2.37944062
62Testicular atrophy (HP:0000029)2.36988872
63Colon cancer (HP:0003003)2.36697465
64Exertional dyspnea (HP:0002875)2.31705039
65Selective tooth agenesis (HP:0001592)2.31322291
66Nausea (HP:0002018)2.30515666
67Fat malabsorption (HP:0002630)2.28065055
68Steatorrhea (HP:0002570)2.28018000
69Pallor (HP:0000980)2.27522914
70Hypolipoproteinemia (HP:0010981)2.25473818
71Lethargy (HP:0001254)2.24046028
72Recurrent bacterial skin infections (HP:0005406)2.22256111
73Abnormality of pyrimidine metabolism (HP:0004353)2.21670164
74Methylmalonic acidemia (HP:0002912)2.20578684
75Myositis (HP:0100614)2.19573242
76IgM deficiency (HP:0002850)2.19179876
77Pancreatic cysts (HP:0001737)2.18489653
78Breast hypoplasia (HP:0003187)2.18418639
79Prolonged partial thromboplastin time (HP:0003645)2.17666337
80Meckel diverticulum (HP:0002245)2.17131932
81Hyperbilirubinemia (HP:0002904)2.16687365
82Abnormality of alanine metabolism (HP:0010916)2.15505660
83Hyperalaninemia (HP:0003348)2.15505660
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15505660
85Hypoplasia of the pons (HP:0012110)2.15412557
86Dicarboxylic aciduria (HP:0003215)2.15012169
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15012169
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14287140
89Methylmalonic aciduria (HP:0012120)2.13972616
90Death in infancy (HP:0001522)2.13739689
91Chromsome breakage (HP:0040012)2.13364325
92Increased serum lactate (HP:0002151)2.12530414
93Abnormality of the pons (HP:0007361)2.12275598
94Reduced antithrombin III activity (HP:0001976)2.10799831
95Pancytopenia (HP:0001876)2.10318459
96Lip pit (HP:0100267)2.10269940
97Deep venous thrombosis (HP:0002625)2.09175281
98Amaurosis fugax (HP:0100576)2.08536168
99Abnormality of the ileum (HP:0001549)2.06808029
100Hypoglycemic coma (HP:0001325)2.06702656
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05759062
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05759062
103Facial hemangioma (HP:0000329)2.05331611
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05292440
105Aplasia/hypoplasia of the uterus (HP:0008684)2.04395837
106Gingival bleeding (HP:0000225)2.03379509
107Nonimmune hydrops fetalis (HP:0001790)2.03261472
108Progressive muscle weakness (HP:0003323)2.00993254
109Premature ovarian failure (HP:0008209)1.99495478
110Spastic diplegia (HP:0001264)1.98593734
111Abnormality of the labia minora (HP:0012880)1.97900081
112Cerebral hypomyelination (HP:0006808)1.97094927
113Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95409566
114Abnormality of methionine metabolism (HP:0010901)1.95405618
115Abnormality of the preputium (HP:0100587)1.95281203
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94247078
117Recurrent abscess formation (HP:0002722)1.93980401
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.93872369
119Reticulocytopenia (HP:0001896)1.92318778
120Abnormality of sulfur amino acid metabolism (HP:0004339)1.91842331
121Gout (HP:0001997)1.91560949
122Hyperlipoproteinemia (HP:0010980)1.90799786
123CNS demyelination (HP:0007305)1.90748786
124Glycosuria (HP:0003076)1.89957576
125Abnormality of urine glucose concentration (HP:0011016)1.89957576
126Subcapsular cataract (HP:0000523)1.89353420
127Horseshoe kidney (HP:0000085)1.87006305
128Megaloblastic anemia (HP:0001889)1.86179993
129Neuroendocrine neoplasm (HP:0100634)1.85608780
130Trismus (HP:0000211)1.85179882
131Opisthotonus (HP:0002179)1.85143292
132Absent thumb (HP:0009777)1.84496159
133Pheochromocytoma (HP:0002666)1.84091259
134Aplastic anemia (HP:0001915)1.83709705
135Delayed CNS myelination (HP:0002188)1.82923060
136Poor head control (HP:0002421)1.82917811
137Triphalangeal thumb (HP:0001199)1.82552932
138Epistaxis (HP:0000421)1.82503205
139Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82093038
140Ketosis (HP:0001946)1.80975285
141Sparse eyelashes (HP:0000653)1.80834913
142Spastic paraparesis (HP:0002313)1.80262288
143Rough bone trabeculation (HP:0100670)1.78479554
144Abnormality of iron homeostasis (HP:0011031)1.77687658
145T lymphocytopenia (HP:0005403)1.77579781
146Abnormality of the anterior horn cell (HP:0006802)1.77450117
147Degeneration of anterior horn cells (HP:0002398)1.77450117
148Thrombophlebitis (HP:0004418)1.77424270
149Cleft eyelid (HP:0000625)1.76901270
150Petechiae (HP:0000967)1.76800312
151Increased CSF lactate (HP:0002490)1.76757426
152Lactic acidosis (HP:0003128)1.75488545
153Bilateral microphthalmos (HP:0007633)1.72778953
154X-linked dominant inheritance (HP:0001423)1.69296386
155Emotional lability (HP:0000712)1.68931319
156Pendular nystagmus (HP:0012043)1.66642501
157Sclerocornea (HP:0000647)1.64273542
158Abnormality of renal resorption (HP:0011038)1.64108618
159Hyperphosphaturia (HP:0003109)1.63249241
160Hypoplasia of the uterus (HP:0000013)1.62229465
161CNS hypomyelination (HP:0003429)1.61222979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.75949957
2WEE13.46557241
3BUB13.23139247
4EIF2AK12.96797210
5TGFBR12.96205969
6NME22.94645613
7PBK2.71577474
8TSSK62.54538377
9NEK12.44180158
10BCKDK2.43261552
11MAP4K12.24928830
12EIF2AK32.05764830
13NEK21.95856566
14STK161.94200298
15CDK81.82754088
16NUAK11.82342347
17BRSK21.79788708
18MAP3K111.72423645
19TAF11.70206248
20STK101.68800388
21MAP4K21.67716181
22MAP2K31.67271924
23PASK1.62756724
24KDR1.53811310
25ERN11.49312402
26NEK91.48744358
27ACVR1B1.48249321
28BMPR1B1.45957654
29BRSK11.45425483
30PIM21.44181878
31CDC71.36730726
32PAK41.36032516
33CCNB11.34588754
34PLK11.34361335
35TEC1.32806859
36MAP3K31.30650508
37TYK21.29797894
38SCYL21.29715003
39BTK1.25218961
40DYRK31.24760611
41TAOK21.24100380
42ZAK1.22945448
43NME11.22414207
44AURKA1.21746295
45TTK1.21593008
46CDK41.21286610
47MAP3K81.19626958
48TBK11.18571867
49PKN21.16477142
50TESK21.14577918
51ATR1.14248115
52AURKB1.08686740
53WNK31.07888526
54GRK61.07374929
55CDK71.06308638
56RPS6KB21.05512191
57PLK41.02458924
58MST41.01652177
59TRIM280.99555343
60KIT0.96664396
61TLK10.94578695
62ERBB30.94300325
63PDK40.94192891
64PDK30.94192891
65LRRK20.93432697
66EPHA20.92013948
67TESK10.91628380
68SRPK10.91352760
69RPS6KA40.90130819
70ZAP700.89613789
71MAP2K20.89291624
72CSNK1G30.88016883
73DYRK20.86777854
74LIMK10.85442653
75EIF2AK20.84738764
76CHEK20.84339312
77MAP3K120.82304106
78PRKCI0.81434274
79CSNK1G10.81207718
80MAP3K100.80293706
81JAK30.79251506
82WNK40.77529230
83ADRBK20.77201529
84FLT30.73417140
85MKNK10.72884432
86VRK10.72135396
87CDK60.72007124
88NLK0.70495722
89PIM10.68515230
90RPS6KA50.67094269
91DAPK10.66706401
92STK40.65765807
93ITK0.64759460
94TRIB30.64146998
95MAPK110.63693181
96IKBKE0.62515483
97MUSK0.62235767
98EEF2K0.62145065
99PHKG10.61506816
100PHKG20.61506816
101CSNK2A20.60147155
102LCK0.59850927
103PLK30.59683187
104CSF1R0.59467457
105CSNK1A1L0.59044485
106MARK30.58813366
107BLK0.58700237
108FGFR40.57867479
109GRK10.57416176
110ABL20.57378990
111MAP2K70.57249417
112CSNK1G20.55738809
113CSNK2A10.55554913
114TXK0.55209254
115LYN0.53962161
116CDK190.51414008
117ARAF0.51343419
118STK38L0.50519637
119MAPK40.48944823
120CHEK10.47355869
121MKNK20.47117562
122TGFBR20.46208156
123ALK0.44522742
124ATM0.42135823
125IKBKB0.42066048
126TAOK10.41403785
127SYK0.40921077
128DAPK30.40392216
129ILK0.39796508
130TNIK0.39236981
131OXSR10.37155606
132PDK20.34871270
133INSRR0.33893611
134MAP3K40.32887560
135AKT20.30617501
136ERBB40.29216036
137PAK10.27983216
138MST1R0.26455170
139CSNK1E0.25606905
140CDK20.23603186
141LMTK20.22762633

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.54788239
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33301597
3Mismatch repair_Homo sapiens_hsa034303.33009202
4Drug metabolism - other enzymes_Homo sapiens_hsa009832.93203554
5Proteasome_Homo sapiens_hsa030502.78726181
6Ribosome_Homo sapiens_hsa030102.78671701
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62708806
8RNA polymerase_Homo sapiens_hsa030202.33707326
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.33157634
10Base excision repair_Homo sapiens_hsa034102.32619738
11Alzheimers disease_Homo sapiens_hsa050102.10573853
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06796644
13Pyrimidine metabolism_Homo sapiens_hsa002402.04082802
14One carbon pool by folate_Homo sapiens_hsa006701.99650006
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85982578
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85162244
17Nucleotide excision repair_Homo sapiens_hsa034201.79655862
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.68161633
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67250434
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66120205
21Retinol metabolism_Homo sapiens_hsa008301.63911651
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62591751
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62027838
24Pentose phosphate pathway_Homo sapiens_hsa000301.61192122
25RNA transport_Homo sapiens_hsa030131.60561045
26Spliceosome_Homo sapiens_hsa030401.60078402
27Folate biosynthesis_Homo sapiens_hsa007901.57986475
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54299517
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.50990559
30Chemical carcinogenesis_Homo sapiens_hsa052041.50318927
31Homologous recombination_Homo sapiens_hsa034401.49547498
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.45126448
33Vitamin B6 metabolism_Homo sapiens_hsa007501.43048202
34Sulfur relay system_Homo sapiens_hsa041221.36099054
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.35619824
36Carbon metabolism_Homo sapiens_hsa012001.35541103
37Glutathione metabolism_Homo sapiens_hsa004801.35062432
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34880995
39Biosynthesis of amino acids_Homo sapiens_hsa012301.34449289
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28733578
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28093664
42Cardiac muscle contraction_Homo sapiens_hsa042601.27736864
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19490430
44Starch and sucrose metabolism_Homo sapiens_hsa005001.17718224
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15588228
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13421791
47Cell cycle_Homo sapiens_hsa041101.13071973
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07986498
49Selenocompound metabolism_Homo sapiens_hsa004501.02970232
50Fatty acid degradation_Homo sapiens_hsa000711.01301237
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99721957
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98076804
53Steroid biosynthesis_Homo sapiens_hsa001000.95580374
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90802284
55Propanoate metabolism_Homo sapiens_hsa006400.90316927
56Tryptophan metabolism_Homo sapiens_hsa003800.87835854
57Purine metabolism_Homo sapiens_hsa002300.87301469
58beta-Alanine metabolism_Homo sapiens_hsa004100.86981037
59Arginine biosynthesis_Homo sapiens_hsa002200.86726156
60Caffeine metabolism_Homo sapiens_hsa002320.86518603
61RNA degradation_Homo sapiens_hsa030180.85234857
62Peroxisome_Homo sapiens_hsa041460.83804327
63Fructose and mannose metabolism_Homo sapiens_hsa000510.81069672
64Pyruvate metabolism_Homo sapiens_hsa006200.81061038
65Vitamin digestion and absorption_Homo sapiens_hsa049770.79428930
66Arginine and proline metabolism_Homo sapiens_hsa003300.78030312
67Fatty acid elongation_Homo sapiens_hsa000620.77696578
68Butanoate metabolism_Homo sapiens_hsa006500.76152353
69Antigen processing and presentation_Homo sapiens_hsa046120.73209611
70Phenylalanine metabolism_Homo sapiens_hsa003600.72678324
71Complement and coagulation cascades_Homo sapiens_hsa046100.68963020
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68662486
73Galactose metabolism_Homo sapiens_hsa000520.65415084
74Fatty acid metabolism_Homo sapiens_hsa012120.65164160
75N-Glycan biosynthesis_Homo sapiens_hsa005100.64241633
76p53 signaling pathway_Homo sapiens_hsa041150.63581262
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62964535
78Primary immunodeficiency_Homo sapiens_hsa053400.61912255
79Staphylococcus aureus infection_Homo sapiens_hsa051500.61518877
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59548537
81Epstein-Barr virus infection_Homo sapiens_hsa051690.58253637
82Metabolic pathways_Homo sapiens_hsa011000.57812975
83Non-homologous end-joining_Homo sapiens_hsa034500.52899323
84Fat digestion and absorption_Homo sapiens_hsa049750.49460738
85Histidine metabolism_Homo sapiens_hsa003400.49445715
86Systemic lupus erythematosus_Homo sapiens_hsa053220.49101010
87Collecting duct acid secretion_Homo sapiens_hsa049660.49026515
88Herpes simplex infection_Homo sapiens_hsa051680.48879294
89Tyrosine metabolism_Homo sapiens_hsa003500.48592700
90Nitrogen metabolism_Homo sapiens_hsa009100.47078167
91Legionellosis_Homo sapiens_hsa051340.46690200
92Basal transcription factors_Homo sapiens_hsa030220.44931999
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37602795
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37398217
95Oocyte meiosis_Homo sapiens_hsa041140.37059236
96Protein export_Homo sapiens_hsa030600.36544368
97Basal cell carcinoma_Homo sapiens_hsa052170.36111872
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.34532522
99PPAR signaling pathway_Homo sapiens_hsa033200.33247152
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33144739
101Parkinsons disease_Homo sapiens_hsa050120.33088880
102Regulation of autophagy_Homo sapiens_hsa041400.28775976
103Fanconi anemia pathway_Homo sapiens_hsa034600.28266504
104Oxidative phosphorylation_Homo sapiens_hsa001900.27956178
105Sulfur metabolism_Homo sapiens_hsa009200.26979350
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25750019
107Hedgehog signaling pathway_Homo sapiens_hsa043400.24250689
108Measles_Homo sapiens_hsa051620.23892028
109Other glycan degradation_Homo sapiens_hsa005110.23484938
110Lysine degradation_Homo sapiens_hsa003100.21954067
111Phototransduction_Homo sapiens_hsa047440.21085261
112Apoptosis_Homo sapiens_hsa042100.20301198
113mRNA surveillance pathway_Homo sapiens_hsa030150.19565839
114Huntingtons disease_Homo sapiens_hsa050160.17984449
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17371093
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15344498
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14561918
118Alcoholism_Homo sapiens_hsa050340.12150695

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