ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of NFAT protein import into nucleus (GO:0051532)	7.95107761
2	cytoplasmic mRNA processing body assembly (GO:0033962)	7.64873453
3	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	7.24957081
4	neurofilament cytoskeleton organization (GO:0060052)	6.92079749
5	protein localization to microtubule (GO:0035372)	6.74350189
6	regulation of meiosis I (GO:0060631)	6.66619087
7	regulation of glycogen (starch) synthase activity (GO:2000465)	6.23798638
8	negative regulation of glycogen biosynthetic process (GO:0045719)	5.80259177
9	positive regulation of action potential (GO:0045760)	5.77009109
10	type B pancreatic cell proliferation (GO:0044342)	5.75888511
11	negative regulation of dendrite morphogenesis (GO:0050774)	5.09940719
12	negative regulation of dendrite development (GO:2000171)	5.07309465
13	neuromuscular process controlling posture (GO:0050884)	5.06943726
14	DNA deamination (GO:0045006)	5.05519385
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.04582779
16	ER overload response (GO:0006983)	4.97192909
17	replication fork processing (GO:0031297)	4.87533115
18	negative regulation of glycogen metabolic process (GO:0070874)	4.68097869
19	dopamine biosynthetic process (GO:0042416)	4.40484390
20	response to insecticide (GO:0017085)	4.38146999
21	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	4.37670039
22	eosinophil chemotaxis (GO:0048245)	4.35580195
23	negative regulation of cardiac muscle hypertrophy (GO:0010614)	4.33868683
24	regulation of Rac protein signal transduction (GO:0035020)	4.31583787
25	response to auditory stimulus (GO:0010996)	4.16977347
26	negative regulation of muscle hypertrophy (GO:0014741)	4.15942653
27	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	4.10974627
28	protein localization to microtubule cytoskeleton (GO:0072698)	4.08273112
29	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.00190185
30	eosinophil migration (GO:0072677)	3.92255013
31	synapsis (GO:0007129)	3.74109591
32	nucleotide transmembrane transport (GO:1901679)	3.73574658
33	platelet dense granule organization (GO:0060155)	3.71431443
34	resolution of meiotic recombination intermediates (GO:0000712)	3.70607320
35	glucosamine-containing compound catabolic process (GO:1901072)	3.70351783
36	cytidine deamination (GO:0009972)	3.64683061
37	cytidine metabolic process (GO:0046087)	3.64683061
38	cytidine catabolic process (GO:0006216)	3.64683061
39	male meiosis I (GO:0007141)	3.61835250
40	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.56825106
41	negative regulation of B cell mediated immunity (GO:0002713)	3.56825106
42	detection of calcium ion (GO:0005513)	3.53168595
43	postreplication repair (GO:0006301)	3.48358375
44	signal peptide processing (GO:0006465)	3.41765689
45	inner mitochondrial membrane organization (GO:0007007)	3.41513533
46	detection of light stimulus involved in sensory perception (GO:0050962)	3.33498000
47	detection of light stimulus involved in visual perception (GO:0050908)	3.33498000
48	vesicle transport along microtubule (GO:0047496)	3.33125830
49	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	3.31277364
50	protein localization to cytoskeleton (GO:0044380)	3.30003364
51	regulation of cell maturation (GO:1903429)	3.27601639
52	positive regulation of meiosis (GO:0045836)	3.23887625
53	transmission of nerve impulse (GO:0019226)	3.19542702
54	oligosaccharide biosynthetic process (GO:0009312)	3.17356834
55	vitamin transmembrane transport (GO:0035461)	3.16179612
56	cartilage morphogenesis (GO:0060536)	3.14232644
57	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10413446
58	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.09523863
59	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.08892297
60	regulation of action potential (GO:0098900)	3.07352297
61	RNA destabilization (GO:0050779)	3.06145621
62	otic vesicle formation (GO:0030916)	3.04804248
63	positive regulation of meiotic cell cycle (GO:0051446)	3.01734023
64	regulation of DNA methylation (GO:0044030)	3.00244275
65	DNA double-strand break processing (GO:0000729)	2.99393285
66	negative regulation of signal transduction by p53 class mediator (GO:1901797)	2.99294742
67	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.99288197
68	microtubule nucleation (GO:0007020)	2.96444230
69	embryonic process involved in female pregnancy (GO:0060136)	2.93990242
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.92503407
71	positive regulation of gluconeogenesis (GO:0045722)	2.90540315
72	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.86755177
73	negative regulation of stem cell proliferation (GO:2000647)	2.85530984
74	retina layer formation (GO:0010842)	2.83659795
75	positive regulation by host of viral transcription (GO:0043923)	2.81199394
76	somite rostral/caudal axis specification (GO:0032525)	2.79060827
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.78812359
78	thalamus development (GO:0021794)	2.78473628
79	protein prenylation (GO:0018342)	2.78015409
80	prenylation (GO:0097354)	2.78015409
81	positive regulation of protein export from nucleus (GO:0046827)	2.77889817
82	protein localization to kinetochore (GO:0034501)	2.73197534
83	coenzyme A biosynthetic process (GO:0015937)	2.72084499
84	regulation of vitamin D biosynthetic process (GO:0060556)	2.69885854
85	modulation by host of viral transcription (GO:0043921)	2.69680603
86	modulation by host of symbiont transcription (GO:0052472)	2.69680603
87	acrosome assembly (GO:0001675)	2.69667305
88	meiosis I (GO:0007127)	2.68413346
89	catechol-containing compound biosynthetic process (GO:0009713)	2.66960671
90	catecholamine biosynthetic process (GO:0042423)	2.66960671
91	DNA strand renaturation (GO:0000733)	2.66928274
92	galactose metabolic process (GO:0006012)	2.64501220
93	regulation of hexokinase activity (GO:1903299)	2.64118330
94	regulation of glucokinase activity (GO:0033131)	2.64118330
95	alkaloid metabolic process (GO:0009820)	2.63643890
96	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.62257207
97	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.62257207
98	positive regulation of protein autophosphorylation (GO:0031954)	2.61165489
99	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.57725054
100	positive regulation of T cell apoptotic process (GO:0070234)	2.57494784

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.93753656
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.92081963
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.68614107
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.50118327
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.40017746
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.00357953
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.98771648
8	FUS_26573619_Chip-Seq_HEK293_Human	2.97696373
9	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.89804026
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.78321450
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43862317
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.41855542
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.34470972
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26589969
15	JUN_21703547_ChIP-Seq_K562_Human	2.19066526
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.15833589
17	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.10324604
18	P300_19829295_ChIP-Seq_ESCs_Human	2.07469960
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01935028
20	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.97172622
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93843375
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91692457
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90999625
24	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.90954562
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.89861484
26	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.89575119
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85242498
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.79006439
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.78229028
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.77852515
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73995815
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71616488
33	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.70911566
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.68847972
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65182209
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63831995
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63831279
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61773666
39	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.61537045
40	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.51453329
41	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.49821174
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47965720
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47792781
44	EWS_26573619_Chip-Seq_HEK293_Human	1.46496074
45	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.43441134
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41839255
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41756784
48	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.37732174
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36667418
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.36210804
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36018353
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35618016
53	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.34848898
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33762241
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.32906275
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31041282
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31041282
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30709099
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29768884
60	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.29651936
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29363550
62	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.28261035
63	VDR_22108803_ChIP-Seq_LS180_Human	1.26779865
64	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.26612423
65	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.26195129
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26137677
67	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22492157
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19427286
69	AR_25329375_ChIP-Seq_VCAP_Human	1.18291568
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.18154976
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17301848
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16929428
73	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.15371108
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15333256
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.15257035
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13596090
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13251004
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11758249
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11665500
80	BCAT_22108803_ChIP-Seq_LS180_Human	1.11186029
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10508954
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10235534
83	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07544768
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.05130936
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04661825
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02939620
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02939620
88	STAT3_23295773_ChIP-Seq_U87_Human	1.02325961
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.01431598
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.99802995
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99802995
92	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.99051800
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98569791
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98406538
95	REST_21632747_ChIP-Seq_MESCs_Mouse	0.97457819
96	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.97453068
97	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.95946099
98	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.95071253
99	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.94848110
100	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.93739656

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	8.26470141
2	MP0006292_abnormal_olfactory_placode	3.26549739
3	MP0005075_abnormal_melanosome_morpholog	3.25478381
4	MP0002277_abnormal_respiratory_mucosa	2.93614449
5	MP0000566_synostosis	2.91129921
6	MP0006082_CNS_inflammation	2.90619426
7	MP0006054_spinal_hemorrhage	2.73875645
8	MP0000015_abnormal_ear_pigmentation	2.52998589
9	MP0002095_abnormal_skin_pigmentation	2.50949629
10	MP0000372_irregular_coat_pigmentation	2.26747528
11	MP0000371_diluted_coat_color	2.05880705
12	MP0001529_abnormal_vocalization	2.02671424
13	MP0002735_abnormal_chemical_nociception	1.92915056
14	MP0002938_white_spotting	1.86415500
15	MP0003121_genomic_imprinting	1.84874184
16	MP0002102_abnormal_ear_morphology	1.84761406
17	MP0003122_maternal_imprinting	1.79195844
18	MP0003221_abnormal_cardiomyocyte_apopto	1.68083588
19	MP0005174_abnormal_tail_pigmentation	1.66542505
20	MP0005377_hearing/vestibular/ear_phenot	1.65320343
21	MP0003878_abnormal_ear_physiology	1.65320343
22	MP0002396_abnormal_hematopoietic_system	1.62662884
23	MP0000383_abnormal_hair_follicle	1.53235875
24	MP0001293_anophthalmia	1.49958341
25	MP0005408_hypopigmentation	1.49133775
26	MP0005423_abnormal_somatic_nervous	1.47845735
27	MP0004924_abnormal_behavior	1.46201919
28	MP0005386_behavior/neurological_phenoty	1.46201919
29	MP0004885_abnormal_endolymph	1.45540271
30	MP0003890_abnormal_embryonic-extraembry	1.45408280
31	MP0001324_abnormal_eye_pigmentation	1.36875471
32	MP0003195_calcinosis	1.35885260
33	MP0000778_abnormal_nervous_system	1.34717596
34	MP0001984_abnormal_olfaction	1.28807829
35	MP0001905_abnormal_dopamine_level	1.27664045
36	MP0010329_abnormal_lipoprotein_level	1.23386647
37	MP0002075_abnormal_coat/hair_pigmentati	1.22067925
38	MP0003646_muscle_fatigue	1.20922816
39	MP0008058_abnormal_DNA_repair	1.19640351
40	MP0000579_abnormal_nail_morphology	1.18735469
41	MP0004381_abnormal_hair_follicle	1.13620806
42	MP0002210_abnormal_sex_determination	1.13373026
43	MP0001186_pigmentation_phenotype	1.13016212
44	MP0008877_abnormal_DNA_methylation	1.12652126
45	MP0004142_abnormal_muscle_tone	1.12386423
46	MP0008872_abnormal_physiological_respon	1.05406770
47	MP0004742_abnormal_vestibular_system	1.05371142
48	MP0002572_abnormal_emotion/affect_behav	1.04869566
49	MP0006036_abnormal_mitochondrial_physio	1.04137742
50	MP0005171_absent_coat_pigmentation	1.03208463
51	MP0002090_abnormal_vision	1.02070105
52	MP0003938_abnormal_ear_development	1.00363509
53	MP0001501_abnormal_sleep_pattern	0.98443985
54	MP0003698_abnormal_male_reproductive	0.97794126
55	MP0005253_abnormal_eye_physiology	0.97104038
56	MP0003786_premature_aging	0.96660411
57	MP0001348_abnormal_lacrimal_gland	0.96171291
58	MP0010678_abnormal_skin_adnexa	0.95580883
59	MP0002557_abnormal_social/conspecific_i	0.95480633
60	MP0000653_abnormal_sex_gland	0.94682170
61	MP0003937_abnormal_limbs/digits/tail_de	0.93836700
62	MP0001145_abnormal_male_reproductive	0.93561286
63	MP0001929_abnormal_gametogenesis	0.93395622
64	MP0001851_eye_inflammation	0.91220814
65	MP0005671_abnormal_response_to	0.90935342
66	MP0006035_abnormal_mitochondrial_morpho	0.89770924
67	MP0005197_abnormal_uvea_morphology	0.87981134
68	MP0001485_abnormal_pinna_reflex	0.87542893
69	MP0010094_abnormal_chromosome_stability	0.86681597
70	MP0009250_abnormal_appendicular_skeleto	0.85606629
71	MP0002063_abnormal_learning/memory/cond	0.85186761
72	MP0006072_abnormal_retinal_apoptosis	0.84435714
73	MP0002098_abnormal_vibrissa_morphology	0.83088196
74	MP0002177_abnormal_outer_ear	0.81029689
75	MP0005448_abnormal_energy_balance	0.79128340
76	MP0002272_abnormal_nervous_system	0.78880665
77	MP0006276_abnormal_autonomic_nervous	0.76659968
78	MP0005187_abnormal_penis_morphology	0.74376234
79	MP0001119_abnormal_female_reproductive	0.74291396
80	MP0003755_abnormal_palate_morphology	0.71871479
81	MP0005464_abnormal_platelet_physiology	0.70077253
82	MP0002282_abnormal_trachea_morphology	0.69684758
83	MP0003137_abnormal_impulse_conducting	0.68010052
84	MP0000955_abnormal_spinal_cord	0.66030217
85	MP0000647_abnormal_sebaceous_gland	0.65448198
86	MP0001486_abnormal_startle_reflex	0.65090987
87	MP0002752_abnormal_somatic_nervous	0.65083690
88	MP0003763_abnormal_thymus_physiology	0.64106728
89	MP0003635_abnormal_synaptic_transmissio	0.63844203
90	MP0002168_other_aberrant_phenotype	0.63622313
91	MP0002233_abnormal_nose_morphology	0.62963262
92	MP0009745_abnormal_behavioral_response	0.62196636
93	MP0000026_abnormal_inner_ear	0.61994583
94	MP0005395_other_phenotype	0.60944634
95	MP0002160_abnormal_reproductive_system	0.60633390
96	MP0005389_reproductive_system_phenotype	0.60054011
97	MP0009765_abnormal_xenobiotic_induced	0.59941565
98	MP0005452_abnormal_adipose_tissue	0.59644206
99	MP0002067_abnormal_sensory_capabilities	0.58600629
100	MP0003718_maternal_effect	0.58347745

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amyotrophic lateral sclerosis (HP:0007354)	7.02378250
2	Limb hypertonia (HP:0002509)	5.81107678
3	Abnormality of the corticospinal tract (HP:0002492)	4.78228693
4	Abnormal pupillary function (HP:0007686)	4.52593819
5	Limb dystonia (HP:0002451)	4.45552362
6	Hypothermia (HP:0002045)	4.07838251
7	Episodic fever (HP:0001954)	3.96547088
8	Atrophy/Degeneration involving motor neurons (HP:0007373)	3.85792277
9	Pancreatic islet-cell hyperplasia (HP:0004510)	3.81222286
10	Short tibia (HP:0005736)	3.75617981
11	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.56605238
12	Toxemia of pregnancy (HP:0100603)	3.34434833
13	Congenital sensorineural hearing impairment (HP:0008527)	3.20649569
14	Acute encephalopathy (HP:0006846)	3.15583758
15	Volvulus (HP:0002580)	3.12534186
16	Spastic tetraparesis (HP:0001285)	3.08770768
17	Stomatitis (HP:0010280)	3.00807996
18	Neonatal hypoglycemia (HP:0001998)	2.97136035
19	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.89392465
20	Acute necrotizing encephalopathy (HP:0006965)	2.77397292
21	Albinism (HP:0001022)	2.74809260
22	Bile duct proliferation (HP:0001408)	2.71607166
23	Abnormal biliary tract physiology (HP:0012439)	2.71607166
24	Inability to walk (HP:0002540)	2.68948883
25	Severe visual impairment (HP:0001141)	2.65809246
26	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.62720545
27	Short 4th metacarpal (HP:0010044)	2.62720545
28	Increased nuchal translucency (HP:0010880)	2.62249134
29	Aqueductal stenosis (HP:0002410)	2.58503491
30	Sensory axonal neuropathy (HP:0003390)	2.55824096
31	Neoplasm of the adrenal cortex (HP:0100641)	2.52691589
32	Progressive macrocephaly (HP:0004481)	2.52644507
33	Iris hypopigmentation (HP:0007730)	2.52372028
34	Long clavicles (HP:0000890)	2.46826170
35	Patchy hypopigmentation of hair (HP:0011365)	2.46104353
36	Malignant hyperthermia (HP:0002047)	2.43979130
37	Lower limb hyperreflexia (HP:0002395)	2.43277795
38	Chronic diarrhea (HP:0002028)	2.42024675
39	Cerebral edema (HP:0002181)	2.40549285
40	Abnormality of methionine metabolism (HP:0010901)	2.39931408
41	Ocular albinism (HP:0001107)	2.38228356
42	White forelock (HP:0002211)	2.36078615
43	Mesomelia (HP:0003027)	2.31592733
44	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.31282579
45	Absent epiphyses (HP:0010577)	2.31282579
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.28361862
47	Abnormal lung lobation (HP:0002101)	2.26416752
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.25463946
49	Cerebral hypomyelination (HP:0006808)	2.25429189
50	11 pairs of ribs (HP:0000878)	2.21520230
51	Molar tooth sign on MRI (HP:0002419)	2.21213392
52	Abnormality of midbrain morphology (HP:0002418)	2.21213392
53	Limited elbow extension (HP:0001377)	2.19925737
54	Elfin facies (HP:0004428)	2.19224824
55	Generalized hypopigmentation (HP:0007513)	2.18968495
56	Keratoconjunctivitis sicca (HP:0001097)	2.18368899
57	Dyschromatopsia (HP:0007641)	2.16865726
58	Megalencephaly (HP:0001355)	2.15144735
59	Abnormality of the labia minora (HP:0012880)	2.14386797
60	Abnormality of the carotid arteries (HP:0005344)	2.13485162
61	Congenital stationary night blindness (HP:0007642)	2.13371216
62	Abnormality of the pancreatic islet cells (HP:0006476)	2.12896132
63	Abnormality of endocrine pancreas physiology (HP:0012093)	2.12896132
64	Hyperglycinemia (HP:0002154)	2.07877875
65	Meckel diverticulum (HP:0002245)	2.07769032
66	Barrel-shaped chest (HP:0001552)	2.05512304
67	Abnormality of the lower motor neuron (HP:0002366)	2.02814662
68	Abnormality of the ileum (HP:0001549)	2.02597766
69	Keratoconjunctivitis (HP:0001096)	2.02406074
70	Lip pit (HP:0100267)	2.02364555
71	Mitochondrial inheritance (HP:0001427)	2.01793542
72	Spastic gait (HP:0002064)	2.00090678
73	Achilles tendon contracture (HP:0001771)	1.99803491
74	Disproportionate short-trunk short stature (HP:0003521)	1.97725519
75	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97706960
76	Overriding aorta (HP:0002623)	1.97258134
77	Upper motor neuron abnormality (HP:0002127)	1.96511688
78	Morphological abnormality of the pyramidal tract (HP:0002062)	1.95708549
79	Nonimmune hydrops fetalis (HP:0001790)	1.94027658
80	3-Methylglutaconic aciduria (HP:0003535)	1.93456588
81	Renal cortical cysts (HP:0000803)	1.92247382
82	Emotional lability (HP:0000712)	1.88745883
83	Hand muscle atrophy (HP:0009130)	1.88167544
84	Fibular aplasia (HP:0002990)	1.87601541
85	Tetraplegia (HP:0002445)	1.87342309
86	Increased mean platelet volume (HP:0011877)	1.85945916
87	Xerostomia (HP:0000217)	1.83798455
88	Thyroid-stimulating hormone excess (HP:0002925)	1.83598063
89	Abnormality of the Achilles tendon (HP:0005109)	1.83309634
90	Premature graying of hair (HP:0002216)	1.82296352
91	Increased CSF lactate (HP:0002490)	1.81717484
92	Congenital, generalized hypertrichosis (HP:0004540)	1.81573247
93	Abnormality of the 4th metacarpal (HP:0010012)	1.80648012
94	Abnormality of the preputium (HP:0100587)	1.80100876
95	Constricted visual fields (HP:0001133)	1.79195092
96	Aplasia involving bones of the extremities (HP:0009825)	1.79066015
97	Aplasia involving bones of the upper limbs (HP:0009823)	1.79066015
98	Aplasia of the phalanges of the hand (HP:0009802)	1.79066015
99	Hematochezia (HP:0002573)	1.76623709
100	Lethargy (HP:0001254)	1.76261759

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	9.60631556
2	MAP3K10	4.07683029
3	CAMK1G	3.63557994
4	ERBB3	2.83135914
5	MINK1	2.69230141
6	WEE1	2.53850896
7	BCKDK	2.37533842
8	SGK2	2.04646922
9	LIMK1	1.98193717
10	PLK4	1.91476101
11	CLK1	1.78545826
12	EIF2AK3	1.75485760
13	TRIM28	1.74691248
14	MARK1	1.64983123
15	FRK	1.60064318
16	SGK494	1.59986450
17	SGK223	1.59986450
18	ZAK	1.55180367
19	PRKCH	1.38411826
20	SGK3	1.33657709
21	RPS6KA2	1.14245706
22	PLK2	1.12684353
23	EIF2AK1	1.11717150
24	WNK3	1.04667605
25	RPS6KC1	1.04567999
26	RPS6KL1	1.04567999
27	SRPK1	1.04304650
28	RPS6KA6	1.01891913
29	BUB1	0.97926204
30	PIM2	0.97694715
31	TAF1	0.95244289
32	NUAK1	0.94327064
33	STK16	0.92719684
34	TSSK6	0.91907101
35	CSNK1G1	0.91483087
36	MAP3K12	0.90598864
37	CDK3	0.90481491
38	PIK3CA	0.89564058
39	ADRBK2	0.86709547
40	MAP2K1	0.84443579
41	EIF2AK2	0.82468064
42	PINK1	0.80743368
43	PLK3	0.80585756
44	ATR	0.78587693
45	VRK1	0.76219182
46	DYRK2	0.75538984
47	RPS6KB1	0.73507086
48	PRKCG	0.72852792
49	CDC7	0.72773488
50	MAPK13	0.72310470
51	MKNK2	0.62161730
52	MST4	0.61863263
53	MARK3	0.61193794
54	TGFBR2	0.57371004
55	GRK5	0.56686624
56	SGK1	0.56354927
57	TXK	0.53090884
58	ACVR1B	0.52555172
59	PBK	0.52362936
60	GRK1	0.52241811
61	MAP2K7	0.51923982
62	PIM1	0.50042988
63	MYLK	0.47532009
64	ROCK2	0.43319927
65	INSRR	0.42497754
66	ADRBK1	0.42215116
67	ARAF	0.41512981
68	PLK1	0.40173473
69	CAMK1	0.39973686
70	CSNK1A1L	0.38929283
71	RPS6KA1	0.38012737
72	TAOK3	0.36147421
73	DYRK1A	0.35512110
74	CDK18	0.35035391
75	GSK3A	0.34909697
76	BRSK2	0.34703092
77	FGFR2	0.34397670
78	NEK2	0.34023496
79	ATM	0.33994609
80	PAK3	0.33982468
81	BCR	0.33906003
82	ITK	0.33745252
83	ROCK1	0.33307400
84	TEC	0.30914768
85	CSNK1A1	0.29638839
86	CDK15	0.29420606
87	PRKCE	0.29416692
88	ERBB4	0.29045701
89	CCNB1	0.28073913
90	CSNK1G3	0.27659871
91	FGR	0.26691128
92	KDR	0.26488939
93	CDK14	0.25745734
94	WNK1	0.25596974
95	WNK4	0.24304587
96	CDK11A	0.24022938
97	PRKCZ	0.23975858
98	TNIK	0.23355810
99	AURKA	0.22278861
100	JAK3	0.20992034

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.32275151
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.31232148
3	Proteasome_Homo sapiens_hsa03050	2.82121790
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.42300609
5	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.13991001
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.11900966
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.08356982
8	Non-homologous end-joining_Homo sapiens_hsa03450	1.99265856
9	RNA polymerase_Homo sapiens_hsa03020	1.86196888
10	Parkinsons disease_Homo sapiens_hsa05012	1.85951278
11	Propanoate metabolism_Homo sapiens_hsa00640	1.84311860
12	Primary immunodeficiency_Homo sapiens_hsa05340	1.83697839
13	RNA degradation_Homo sapiens_hsa03018	1.81505987
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72556218
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.63912743
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.62664588
17	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.52181708
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.52123583
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.49859791
20	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.48564415
21	GABAergic synapse_Homo sapiens_hsa04727	1.48530543
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.44056001
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.40032110
24	Taste transduction_Homo sapiens_hsa04742	1.39371489
25	Butanoate metabolism_Homo sapiens_hsa00650	1.38824611
26	Oocyte meiosis_Homo sapiens_hsa04114	1.24494886
27	Histidine metabolism_Homo sapiens_hsa00340	1.16198509
28	Purine metabolism_Homo sapiens_hsa00230	1.14029369
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13673244
30	Morphine addiction_Homo sapiens_hsa05032	1.13014112
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11427391
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09118305
33	Cell cycle_Homo sapiens_hsa04110	1.08385414
34	Tyrosine metabolism_Homo sapiens_hsa00350	1.07240895
35	Insulin secretion_Homo sapiens_hsa04911	1.06723603
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01093521
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.99962785
38	Phototransduction_Homo sapiens_hsa04744	0.99872768
39	Alzheimers disease_Homo sapiens_hsa05010	0.98802755
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.97211691
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96575468
42	Olfactory transduction_Homo sapiens_hsa04740	0.95548566
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.95501365
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92849255
45	Rheumatoid arthritis_Homo sapiens_hsa05323	0.91502845
46	p53 signaling pathway_Homo sapiens_hsa04115	0.91459293
47	Sulfur metabolism_Homo sapiens_hsa00920	0.91447662
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90974421
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.90182881
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89508453
51	Retinol metabolism_Homo sapiens_hsa00830	0.89016336
52	Allograft rejection_Homo sapiens_hsa05330	0.88374649
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86620887
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86327404
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.86299461
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85583816
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.85412290
58	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84026966
59	Peroxisome_Homo sapiens_hsa04146	0.84024271
60	Basal transcription factors_Homo sapiens_hsa03022	0.83273609
61	Basal cell carcinoma_Homo sapiens_hsa05217	0.82881706
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78987710
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.75695405
64	Homologous recombination_Homo sapiens_hsa03440	0.75063016
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.72559899
66	Melanogenesis_Homo sapiens_hsa04916	0.72191074
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.71876919
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.69275235
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69198735
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68458224
71	Huntingtons disease_Homo sapiens_hsa05016	0.68269413
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.67642731
73	Circadian rhythm_Homo sapiens_hsa04710	0.66210261
74	Fatty acid elongation_Homo sapiens_hsa00062	0.65576685
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62434044
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61293808
77	Caffeine metabolism_Homo sapiens_hsa00232	0.61024947
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60512239
79	HTLV-I infection_Homo sapiens_hsa05166	0.60323503
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.57018023
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56127049
82	Antigen processing and presentation_Homo sapiens_hsa04612	0.54941813
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54058944
84	Alcoholism_Homo sapiens_hsa05034	0.53272418
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.53072892
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52463274
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.52138463
88	Amphetamine addiction_Homo sapiens_hsa05031	0.51356898
89	Colorectal cancer_Homo sapiens_hsa05210	0.48058506
90	Cocaine addiction_Homo sapiens_hsa05030	0.47869280
91	RNA transport_Homo sapiens_hsa03013	0.47507629
92	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47112963
93	Chemokine signaling pathway_Homo sapiens_hsa04062	0.46217556
94	Estrogen signaling pathway_Homo sapiens_hsa04915	0.45698426
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.44607980
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44569036
97	Fatty acid degradation_Homo sapiens_hsa00071	0.44212024
98	Circadian entrainment_Homo sapiens_hsa04713	0.41611727
99	Measles_Homo sapiens_hsa05162	0.41568567
100	Sulfur relay system_Homo sapiens_hsa04122	0.41181982

CCDC58P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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